CZ201224A3 - Kyselina hyaluronová znacená tritiem, zpusob znacení kyseliny hyaluronové tritiem a její pouzití - Google Patents
Kyselina hyaluronová znacená tritiem, zpusob znacení kyseliny hyaluronové tritiem a její pouzitíInfo
- Publication number
- CZ201224A3 CZ201224A3 CZ20120024A CZ201224A CZ201224A3 CZ 201224 A3 CZ201224 A3 CZ 201224A3 CZ 20120024 A CZ20120024 A CZ 20120024A CZ 201224 A CZ201224 A CZ 201224A CZ 201224 A3 CZ201224 A3 CZ 201224A3
- Authority
- CZ
- Czechia
- Prior art keywords
- hyaluronic acid
- tritium
- labeled
- labeling
- sup
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 6
- 229920002674 hyaluronan Polymers 0.000 title abstract 6
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 6
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 229910052722 tritium Inorganic materials 0.000 title abstract 3
- 238000002372 labelling Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 229960002442 glucosamine Drugs 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000033116 oxidation-reduction process Effects 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 239000002901 radioactive waste Substances 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Vynález se týká kyseliny hyaluronové znacené tritiem a zpusobu její prípravy. Postup je zalozen na oxidacne-redukcní strategii, kde k oxidaci na aldehyd a redukci zpet na alkohol dochází v poloze 6-glukosaminové cásti polysacharidu. Výsledkem je nativní derivát o molekulové hmotnosti v rozsahu 800 g.mol.sup.-1.n.az 1 000 000 g.mol.sup.-1.n.vykazující vysokou stabilitu a specifickou aktivitu, která je omezená jenom specifickou aktivitou pouzitého redukcního cinidla. Postup prípravy je rychlý, levný a produkuje minimum radioaktivního odpadu v podobe balastu. Znacená kyselina hyaluronová byla testována pri studiích biodistribuce u potkanu, kde byla overena její stabilita detekcí kyseliny hyaluronové po intravenózním podání v moci. Znacená kyselina hyaluronová se muze pouzít v biomedicínských aplikacích.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ20120024A CZ303722B6 (cs) | 2012-01-16 | 2012-01-16 | Kyselina hyaluronová znacená tritiem, zpusob znacení kyseliny hyaluronové tritiem a její pouzití |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ20120024A CZ303722B6 (cs) | 2012-01-16 | 2012-01-16 | Kyselina hyaluronová znacená tritiem, zpusob znacení kyseliny hyaluronové tritiem a její pouzití |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ201224A3 true CZ201224A3 (cs) | 2013-04-03 |
| CZ303722B6 CZ303722B6 (cs) | 2013-04-03 |
Family
ID=47989620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20120024A CZ303722B6 (cs) | 2012-01-16 | 2012-01-16 | Kyselina hyaluronová znacená tritiem, zpusob znacení kyseliny hyaluronové tritiem a její pouzití |
Country Status (1)
| Country | Link |
|---|---|
| CZ (1) | CZ303722B6 (cs) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3074427B1 (en) * | 2013-11-25 | 2021-01-06 | Deuteria Biomaterials, LLC | Deuterium-enriched hyaluronan |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0259485A4 (en) * | 1986-03-14 | 1988-07-29 | Bio Technology General Corp | HEAVY METAL SALTS OF HYALURONIC ACID FOR USE AS AN ANTIMICROBIAL AGENT. |
| CS178890A3 (en) * | 1990-04-10 | 1992-02-19 | Ustav Ex Farmakologie Sav | Method of proof of hyaluronic acid, its salts or radiolabelled derivatives |
| SK280150B6 (sk) * | 1990-12-27 | 1999-09-10 | Výskumný Ústav Reumatických Chorôb | Spôsob prípravy [3h]- alebo [14c]-kyseliny hyaluró |
| AU3239895A (en) * | 1994-08-10 | 1996-03-07 | Roderick T. Coward | Method of using hyaluronic acid for the detection, location and diagnosis of tumors |
| CZ2009836A3 (cs) * | 2009-12-11 | 2011-06-22 | Contipro C A.S. | Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace |
| CZ302503B6 (cs) * | 2009-12-11 | 2011-06-22 | Contipro C A.S. | Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace |
-
2012
- 2012-01-16 CZ CZ20120024A patent/CZ303722B6/cs not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ303722B6 (cs) | 2013-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20170116 |