BRPI0820888B8 - Copolímero de metacrilato de aminoalquila e, seu uso e seu método de produção, e formulação farmacêutica - Google Patents

Copolímero de metacrilato de aminoalquila e, seu uso e seu método de produção, e formulação farmacêutica

Info

Publication number
BRPI0820888B8
BRPI0820888B8 BRPI0820888A BRPI0820888A BRPI0820888B8 BR PI0820888 B8 BRPI0820888 B8 BR PI0820888B8 BR PI0820888 A BRPI0820888 A BR PI0820888A BR PI0820888 A BRPI0820888 A BR PI0820888A BR PI0820888 B8 BRPI0820888 B8 BR PI0820888B8
Authority
BR
Brazil
Prior art keywords
aminoalkyl methacrylate
copolymere
production method
pharmaceutical formulation
aminoalkyl
Prior art date
Application number
BRPI0820888A
Other languages
English (en)
Inventor
Langguth Peter
Grube Stefan
Frey Holger
Obermeier Boris
Original Assignee
Evonik Roehm Gmbh
Roehm Gmbh
Evonik Degussa Gmbh
Evonik Operations Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Roehm Gmbh, Roehm Gmbh, Evonik Degussa Gmbh, Evonik Operations Gmbh filed Critical Evonik Roehm Gmbh
Publication of BRPI0820888A2 publication Critical patent/BRPI0820888A2/pt
Publication of BRPI0820888B1 publication Critical patent/BRPI0820888B1/pt
Publication of BRPI0820888B8 publication Critical patent/BRPI0820888B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F26/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

QUATERNIZAÇÃO DO COPOLÍMERO ADITIVO METACRILATO DE AMINOALQUILA E PARA MELHORAR A PERMEABILIDADE E A SOLUBILIDADE DE PRODUTOS FARMACÊUTICOS. A presente invenção refere-se a uma estratégia para melhorar a permeabilidade e a solubilidade de produtos farmacêuticos, com base na adição de um copolímero de metacrilato de aminoalquila E quimicamente modificado, em que a modificação química é a quaternização de uma proporção dos grupos aminoalquila existentes.
BRPI0820888A 2007-12-13 2008-12-12 Copolímero de metacrilato de aminoalquila e, seu uso e seu método de produção, e formulação farmacêutica BRPI0820888B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007060175A DE102007060175A1 (de) 2007-12-13 2007-12-13 Quartärnisierung des Zusatzstoffs Aminoalkyl Methacrylat Copolymer E zur Verbesserung der Permeabilität und Löslichkeit von Arzneistoffen
DE102007060175.3 2007-12-13
PCT/EP2008/010585 WO2009074336A1 (de) 2007-12-13 2008-12-12 Quartärnisierung des zusatzstoffs aminoalkyl methacrylat copolymer e zur verbesserung der permeabilität und löslichkeit von arzneistoffen

Publications (3)

Publication Number Publication Date
BRPI0820888A2 BRPI0820888A2 (pt) 2015-06-16
BRPI0820888B1 BRPI0820888B1 (pt) 2019-03-26
BRPI0820888B8 true BRPI0820888B8 (pt) 2022-07-05

Family

ID=40339608

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0820888A BRPI0820888B8 (pt) 2007-12-13 2008-12-12 Copolímero de metacrilato de aminoalquila e, seu uso e seu método de produção, e formulação farmacêutica

Country Status (15)

Country Link
US (1) US8399523B2 (pt)
EP (1) EP2219676B1 (pt)
JP (1) JP5645668B2 (pt)
KR (1) KR101573554B1 (pt)
CN (2) CN101896207A (pt)
BR (1) BRPI0820888B8 (pt)
CA (1) CA2708431C (pt)
DE (1) DE102007060175A1 (pt)
ES (1) ES2562444T3 (pt)
HU (1) HUE026739T2 (pt)
IL (1) IL206016A (pt)
MX (1) MX2010006354A (pt)
PL (1) PL2219676T3 (pt)
SI (1) SI2219676T1 (pt)
WO (1) WO2009074336A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5583211B2 (ja) * 2009-07-30 2014-09-03 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング アミノ（メタ）アクリレートポリマー又はコポリマーを含有する水性炭酸媒体
EP3915543A1 (en) 2020-05-28 2021-12-01 Evonik Operations GmbH Solid self-nanoemulsifying drug delivery system (s-snedds)
EP3916029A1 (en) 2020-05-28 2021-12-01 Evonik Operations GmbH Novel methacrylate copolymer and compositions comprising it
IL303390A (en) 2020-12-03 2023-08-01 Battelle Memorial Institute Compositions of polymer nanoparticles and DNA nanostructures and methods for non-viral transport
AU2022253899A1 (en) 2021-04-07 2023-10-26 Battelle Memorial Institute Rapid design, build, test, and learn technologies for identifying and using non-viral carriers

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179549A (en) * 1974-11-14 1979-12-18 Petrolite Corporation Quaternary ammonium adducts of polymerizable tertiary ammonium salts and acrylamide
JPS61174202A (ja) * 1985-01-29 1986-08-05 Mitsubishi Yuka Fine Chem Co Ltd 水溶性の感光性樹脂の製造方法
JPH075683B2 (ja) * 1986-09-09 1995-01-25 三菱レイヨン株式会社 帯電防止性に優れたメタクリル樹脂キヤスト板の製造方法
JP2520659B2 (ja) * 1987-09-10 1996-07-31 東京瓦斯株式会社 センサ―架台の海底着座方法及び装置
DE69528583T2 (de) * 1994-04-22 2003-07-10 Yamanouchi Pharmaceutical Co., Ltd. Kolon-spezifisches arzneistofffreisetzungssystem
DE69725994T2 (de) * 1996-09-19 2004-09-02 The Procter & Gamble Company, Cincinnati Konzentrierte quaternäre ammoniumgewebeweichmacherzusammensetzungen mit kationischen polymeren
IT1294748B1 (it) * 1997-09-17 1999-04-12 Permatec Tech Ag Formulazione per un dispositivo transdermico
FR2804122B1 (fr) * 2000-01-24 2002-02-22 Atofina Dispersions aqueuses sans sel de (co)polymeres hydrosolubles a base de monomeres cationiques, leur procede de fabrication et leurs applications
DE10013029A1 (de) * 2000-03-17 2001-09-20 Roehm Gmbh Mehrschichtige Arzneiform für die Colonfreigabe
AU7105501A (en) 2000-07-17 2002-01-30 Yamanouchi Pharma Co Ltd Pharmaceutical composition improved in peroral absorbability
WO2002060417A1 (de) * 2001-01-29 2002-08-08 Röhm GmbH & Co. KG Lagerstabiles haft- und bindemittel für pharmazeutische anwendungen
GB0114197D0 (en) 2001-06-11 2001-08-01 Syngenta Ltd Reactive polymeric surfactants
US20030095928A1 (en) * 2001-09-19 2003-05-22 Elan Pharma International Limited Nanoparticulate insulin
US6838078B2 (en) * 2002-01-16 2005-01-04 3M Innovative Properties Company Film-forming compositions and methods
GB0228537D0 (en) * 2002-12-06 2003-01-15 Syngenta Ltd Particulate suspensions
GB0229147D0 (en) * 2002-12-13 2003-01-15 Unilever Plc Polymers and laundry detergent compositions containing them
US7087174B2 (en) * 2004-04-08 2006-08-08 Nalco Company Enhanced recovery of useful coal, potassium chloride and borax from screen bowl centrifuge
JP4362093B2 (ja) * 2004-08-06 2009-11-11 大日本印刷株式会社 帯電防止膜形成用の電離放射線硬化性組成物と帯電防止膜および帯電防止膜を備えた構造体
JP2006161259A (ja) * 2004-11-12 2006-06-22 Harima Chem Inc カチオン性表面サイズ剤、及び当該サイズ剤を塗工した紙
EP1810668A1 (en) * 2006-01-23 2007-07-25 LEK Pharmaceuticals D.D. Coated formulations containing tolterodine tartrate

Also Published As

Publication number Publication date
ES2562444T3 (es) 2016-03-04
HUE026739T2 (en) 2016-07-28
BRPI0820888B1 (pt) 2019-03-26
JP2011506370A (ja) 2011-03-03
BRPI0820888A2 (pt) 2015-06-16
EP2219676A1 (de) 2010-08-25
DE102007060175A1 (de) 2009-06-18
SI2219676T1 (sl) 2016-03-31
US20100286288A1 (en) 2010-11-11
IL206016A0 (en) 2010-11-30
CN101896207A (zh) 2010-11-24
EP2219676B1 (de) 2015-12-09
KR101573554B1 (ko) 2015-12-01
CN103897079A (zh) 2014-07-02
PL2219676T3 (pl) 2016-05-31
KR20100106380A (ko) 2010-10-01
MX2010006354A (es) 2010-12-20
WO2009074336A1 (de) 2009-06-18
CA2708431C (en) 2016-01-26
JP5645668B2 (ja) 2014-12-24
CA2708431A1 (en) 2009-06-18
IL206016A (en) 2015-11-30
US8399523B2 (en) 2013-03-19
CN103897079B (zh) 2017-08-18

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/03/2019, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved

Owner name: ROEHM GMBH (DE)

B25G Requested change of headquarter approved

Owner name: ROEHM GMBH (DE)

B25A Requested transfer of rights approved

Owner name: EVONIK DEGUSSA GMBH (DE)

B25D Requested change of name of applicant approved

Owner name: EVONIK OPERATIONS GMBH (DE)

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.