CN103897079B - 添加物甲基丙烯酸氨基烷基酯共聚物e的季铵化以改善药物渗透性和溶解度 - Google Patents
添加物甲基丙烯酸氨基烷基酯共聚物e的季铵化以改善药物渗透性和溶解度 Download PDFInfo
- Publication number
- CN103897079B CN103897079B CN201410112390.1A CN201410112390A CN103897079B CN 103897079 B CN103897079 B CN 103897079B CN 201410112390 A CN201410112390 A CN 201410112390A CN 103897079 B CN103897079 B CN 103897079B
- Authority
- CN
- China
- Prior art keywords
- quaternized
- amino alkyl
- alkyl methacrylate
- sum
- methacrylate copolymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F26/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
BMA | DMAEMA | MMA | |
(m) | (n) | (o) | |
1H NMR | 0.75 | 1.57 | 1 |
制备商数据 | 1 | 2 | 1 |
Claims (10)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007060175A DE102007060175A1 (de) | 2007-12-13 | 2007-12-13 | Quartärnisierung des Zusatzstoffs Aminoalkyl Methacrylat Copolymer E zur Verbesserung der Permeabilität und Löslichkeit von Arzneistoffen |
DE102007060175.3 | 2007-12-13 | ||
CN2008801208052A CN101896207A (zh) | 2007-12-13 | 2008-12-12 | 添加物甲基丙烯酸氨基烷基酯共聚物e的季铵化以改善药物渗透性和溶解度 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008801208052A Division CN101896207A (zh) | 2007-12-13 | 2008-12-12 | 添加物甲基丙烯酸氨基烷基酯共聚物e的季铵化以改善药物渗透性和溶解度 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103897079A CN103897079A (zh) | 2014-07-02 |
CN103897079B true CN103897079B (zh) | 2017-08-18 |
Family
ID=40339608
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410112390.1A Active CN103897079B (zh) | 2007-12-13 | 2008-12-12 | 添加物甲基丙烯酸氨基烷基酯共聚物e的季铵化以改善药物渗透性和溶解度 |
CN2008801208052A Pending CN101896207A (zh) | 2007-12-13 | 2008-12-12 | 添加物甲基丙烯酸氨基烷基酯共聚物e的季铵化以改善药物渗透性和溶解度 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008801208052A Pending CN101896207A (zh) | 2007-12-13 | 2008-12-12 | 添加物甲基丙烯酸氨基烷基酯共聚物e的季铵化以改善药物渗透性和溶解度 |
Country Status (15)
Country | Link |
---|---|
US (1) | US8399523B2 (zh) |
EP (1) | EP2219676B1 (zh) |
JP (1) | JP5645668B2 (zh) |
KR (1) | KR101573554B1 (zh) |
CN (2) | CN103897079B (zh) |
BR (1) | BRPI0820888B8 (zh) |
CA (1) | CA2708431C (zh) |
DE (1) | DE102007060175A1 (zh) |
ES (1) | ES2562444T3 (zh) |
HU (1) | HUE026739T2 (zh) |
IL (1) | IL206016A (zh) |
MX (1) | MX2010006354A (zh) |
PL (1) | PL2219676T3 (zh) |
SI (1) | SI2219676T1 (zh) |
WO (1) | WO2009074336A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2769152C (en) * | 2009-07-30 | 2016-06-07 | Evonik Roehm Gmbh | Aqueous carbonated medium containing an amino(meth)acrylate polymer or copolymer |
EP3915543A1 (en) | 2020-05-28 | 2021-12-01 | Evonik Operations GmbH | Solid self-nanoemulsifying drug delivery system (s-snedds) |
EP3916029A1 (en) | 2020-05-28 | 2021-12-01 | Evonik Operations GmbH | Novel methacrylate copolymer and compositions comprising it |
CN117500923A (zh) | 2021-04-07 | 2024-02-02 | 巴特尔纪念研究院 | 用于鉴定和使用非病毒载体的快速设计、构建、测试和学习技术 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1726239A (zh) * | 2002-12-13 | 2006-01-25 | 荷兰联合利华有限公司 | 聚合物和含该聚合物的洗衣用洗涤剂组合物 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179549A (en) * | 1974-11-14 | 1979-12-18 | Petrolite Corporation | Quaternary ammonium adducts of polymerizable tertiary ammonium salts and acrylamide |
JPS61174202A (ja) * | 1985-01-29 | 1986-08-05 | Mitsubishi Yuka Fine Chem Co Ltd | 水溶性の感光性樹脂の製造方法 |
JPH075683B2 (ja) * | 1986-09-09 | 1995-01-25 | 三菱レイヨン株式会社 | 帯電防止性に優れたメタクリル樹脂キヤスト板の製造方法 |
JP2520659B2 (ja) * | 1987-09-10 | 1996-07-31 | 東京瓦斯株式会社 | センサ―架台の海底着座方法及び装置 |
ES2283503T3 (es) * | 1994-04-22 | 2007-11-01 | Astellas Pharma Inc. | Sistema de liberacion de farmaco especifico de colon. |
EP0931131B1 (en) * | 1996-09-19 | 2004-04-21 | The Procter & Gamble Company | Fabric softeners having increased performance |
IT1294748B1 (it) | 1997-09-17 | 1999-04-12 | Permatec Tech Ag | Formulazione per un dispositivo transdermico |
FR2804122B1 (fr) * | 2000-01-24 | 2002-02-22 | Atofina | Dispersions aqueuses sans sel de (co)polymeres hydrosolubles a base de monomeres cationiques, leur procede de fabrication et leurs applications |
DE10013029A1 (de) * | 2000-03-17 | 2001-09-20 | Roehm Gmbh | Mehrschichtige Arzneiform für die Colonfreigabe |
CA2415643C (en) | 2000-07-17 | 2010-11-16 | Yamanouchi Pharmaceutical Co., Ltd. | Pharmaceutical composition for oral use with improved absorption |
WO2002060417A1 (de) * | 2001-01-29 | 2002-08-08 | Röhm GmbH & Co. KG | Lagerstabiles haft- und bindemittel für pharmazeutische anwendungen |
GB0114197D0 (en) | 2001-06-11 | 2001-08-01 | Syngenta Ltd | Reactive polymeric surfactants |
JP4464129B2 (ja) * | 2001-09-19 | 2010-05-19 | エラン ファーマ インターナショナル,リミティド | ナノ粒子インスリン製剤 |
US6838078B2 (en) * | 2002-01-16 | 2005-01-04 | 3M Innovative Properties Company | Film-forming compositions and methods |
GB0228537D0 (en) | 2002-12-06 | 2003-01-15 | Syngenta Ltd | Particulate suspensions |
US7087174B2 (en) * | 2004-04-08 | 2006-08-08 | Nalco Company | Enhanced recovery of useful coal, potassium chloride and borax from screen bowl centrifuge |
JP4362093B2 (ja) * | 2004-08-06 | 2009-11-11 | 大日本印刷株式会社 | 帯電防止膜形成用の電離放射線硬化性組成物と帯電防止膜および帯電防止膜を備えた構造体 |
JP2006161259A (ja) * | 2004-11-12 | 2006-06-22 | Harima Chem Inc | カチオン性表面サイズ剤、及び当該サイズ剤を塗工した紙 |
EP1810668A1 (en) | 2006-01-23 | 2007-07-25 | LEK Pharmaceuticals D.D. | Coated formulations containing tolterodine tartrate |
-
2007
- 2007-12-13 DE DE102007060175A patent/DE102007060175A1/de not_active Withdrawn
-
2008
- 2008-12-12 EP EP08860544.9A patent/EP2219676B1/de active Active
- 2008-12-12 CN CN201410112390.1A patent/CN103897079B/zh active Active
- 2008-12-12 CA CA2708431A patent/CA2708431C/en active Active
- 2008-12-12 PL PL08860544T patent/PL2219676T3/pl unknown
- 2008-12-12 HU HUE08860544A patent/HUE026739T2/en unknown
- 2008-12-12 KR KR1020107012907A patent/KR101573554B1/ko active IP Right Grant
- 2008-12-12 WO PCT/EP2008/010585 patent/WO2009074336A1/de active Application Filing
- 2008-12-12 ES ES08860544.9T patent/ES2562444T3/es active Active
- 2008-12-12 SI SI200831579T patent/SI2219676T1/sl unknown
- 2008-12-12 US US12/747,722 patent/US8399523B2/en active Active
- 2008-12-12 CN CN2008801208052A patent/CN101896207A/zh active Pending
- 2008-12-12 MX MX2010006354A patent/MX2010006354A/es active IP Right Grant
- 2008-12-12 JP JP2010537322A patent/JP5645668B2/ja not_active Expired - Fee Related
- 2008-12-12 BR BRPI0820888A patent/BRPI0820888B8/pt active IP Right Grant
-
2010
- 2010-05-27 IL IL206016A patent/IL206016A/en active IP Right Grant
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1726239A (zh) * | 2002-12-13 | 2006-01-25 | 荷兰联合利华有限公司 | 聚合物和含该聚合物的洗衣用洗涤剂组合物 |
Also Published As
Publication number | Publication date |
---|---|
CN103897079A (zh) | 2014-07-02 |
JP5645668B2 (ja) | 2014-12-24 |
PL2219676T3 (pl) | 2016-05-31 |
HUE026739T2 (en) | 2016-07-28 |
EP2219676B1 (de) | 2015-12-09 |
WO2009074336A1 (de) | 2009-06-18 |
US20100286288A1 (en) | 2010-11-11 |
KR20100106380A (ko) | 2010-10-01 |
JP2011506370A (ja) | 2011-03-03 |
IL206016A0 (en) | 2010-11-30 |
CA2708431C (en) | 2016-01-26 |
EP2219676A1 (de) | 2010-08-25 |
CN101896207A (zh) | 2010-11-24 |
BRPI0820888B8 (pt) | 2022-07-05 |
MX2010006354A (es) | 2010-12-20 |
IL206016A (en) | 2015-11-30 |
DE102007060175A1 (de) | 2009-06-18 |
ES2562444T3 (es) | 2016-03-04 |
BRPI0820888A2 (pt) | 2015-06-16 |
BRPI0820888B1 (pt) | 2019-03-26 |
SI2219676T1 (sl) | 2016-03-31 |
US8399523B2 (en) | 2013-03-19 |
CA2708431A1 (en) | 2009-06-18 |
KR101573554B1 (ko) | 2015-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11547301B2 (en) | Methods for collecting and testing bacteria containing samples from within the gastrointestinal tract | |
Tekade et al. | Surface-engineered dendrimers for dual drug delivery: a receptor up-regulation and enhanced cancer targeting strategy | |
Kleinman et al. | Effect of protonation and PAMAM dendrimer size on the complexation and dynamic mobility of 2-naphthol | |
CN103897079B (zh) | 添加物甲基丙烯酸氨基烷基酯共聚物e的季铵化以改善药物渗透性和溶解度 | |
CN104936579A (zh) | 用于引发对免疫原的免疫响应的方法 | |
CN103110954A (zh) | 胆固醇修饰的生物可降解聚阳离子载体及制备方法和用途 | |
Andretto et al. | Hybrid core-shell particles for mRNA systemic delivery | |
CN104780926B (zh) | 用于医学应用的带有侧伯胺的聚碳酸酯 | |
US20190160007A1 (en) | Integrated Nano System for Liver-Targeting Co-Delivery of Genes/Drugs and Preparation Method | |
CN103536934A (zh) | 一种基于pamam的自组装纳米基因载体复合物及其制备方法 | |
CN102731775A (zh) | 聚精胺阳离子及其构建方法和纳米颗粒的制备方法 | |
JP2009007547A (ja) | 核酸キャリア及び核酸デリバリー方法 | |
CN103267785A (zh) | 一种检测药物包裹或释放过程的单分子分析方法 | |
US20080187998A1 (en) | Sulfonamide-based oligomers and polymers for destabilization of biological membranes | |
Chowdhary et al. | A Formulation of Paromomycin Sulphate as a Promising Fucose-Conjugated Nanostructured Lipid Carrier for Antileishmanial Drug Delivery | |
CN102675567B (zh) | 一种水溶性可生物降解且高效抗菌的聚合物胶束及其制备方法 | |
CN102516534B (zh) | 可降解为精胺的聚阳离子及其合成方法、纳米颗粒 | |
Kong et al. | Role of size, surface charge, and PEGylated lipids of lipid nanoparticles (LNPs) on intramuscular delivery of mRNA | |
Grooms-Williams et al. | Toxicological Analysis of Avaren-Fc: A Potential HIV Microbicide | |
US20240316205A1 (en) | Composition containing cationic hydroxyethyl cellulose | |
US20230055279A1 (en) | Composition containing cationic hydroxyethyl cellulose | |
CN105764913A (zh) | 用于药物输送的还原性或非还原性多核苷酸聚合物及其制备方法 | |
Jorge | DNA-Polyethylenimine-Fe (III) complexes for gene delivery. A combined Monte Carlo and experimental study |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1198044 Country of ref document: HK |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1198044 Country of ref document: HK |
|
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: Darmstadt Patentee after: Roma Chemical Co.,Ltd. Address before: Darmstadt Patentee before: EVONIK ROHM GmbH Address after: Essen, Germany Patentee after: Evonik Operations Ltd. Address before: Essen, Germany Patentee before: EVONIK DEGUSSA GmbH |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20200624 Address after: Essen, Germany Patentee after: EVONIK DEGUSSA GmbH Address before: Darmstadt Patentee before: Roma Chemical Co.,Ltd. |