BR1100853A - Composto, composição farmacêutica, e composição veterinária - Google Patents

Composto, composição farmacêutica, e composição veterinária

Info

Publication number
BR1100853A
BR1100853A BR1100853-9A BR1100853A BR1100853A BR 1100853 A BR1100853 A BR 1100853A BR 1100853 A BR1100853 A BR 1100853A BR 1100853 A BR1100853 A BR 1100853A
Authority
BR
Brazil
Prior art keywords
composition
compound
veterinary
pharmaceutical composition
disclosed
Prior art date
Application number
BR1100853-9A
Other languages
English (en)
Portuguese (pt)
Inventor
Joseph J Hlavka
Phaik-Eng Sum
Gluzman Yakov
Ving J Lee
Adma A Ross
Original Assignee
Joseph J. Hlavka
Phaik-Eng Sum
Yakov Gluzman (Falecido)
Ving J. Lee
Adma A. Ross
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25092264&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR1100853(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Joseph J. Hlavka, Phaik-Eng Sum, Yakov Gluzman (Falecido), Ving J. Lee, Adma A. Ross filed Critical Joseph J. Hlavka
Publication of BR1100853A publication Critical patent/BR1100853A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals
    • C07D277/46Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30Hetero atoms other than halogen
    • C07D333/34Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/40Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/461,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Moulding By Coating Moulds (AREA)
BR1100853-9A 1991-10-04 1997-05-12 Composto, composição farmacêutica, e composição veterinária BR1100853A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77157691A 1991-10-04 1991-10-04

Publications (1)

Publication Number Publication Date
BR1100853A true BR1100853A (pt) 1999-12-07

Family

ID=25092264

Family Applications (1)

Application Number Title Priority Date Filing Date
BR1100853-9A BR1100853A (pt) 1991-10-04 1997-05-12 Composto, composição farmacêutica, e composição veterinária

Country Status (27)

Country Link
EP (1) EP0536515B1 (enExample)
JP (1) JP3186863B2 (enExample)
KR (1) KR100269072B1 (enExample)
CN (1) CN1048240C (enExample)
AT (1) ATE211128T1 (enExample)
AU (1) AU654049B2 (enExample)
BR (1) BR1100853A (enExample)
CA (1) CA2079692C (enExample)
CL (1) CL2004001623A1 (enExample)
CZ (2) CZ309397A3 (enExample)
DE (4) DE122006000058I1 (enExample)
DK (1) DK0536515T3 (enExample)
ES (1) ES2168254T3 (enExample)
FI (1) FI114911B (enExample)
HU (2) HU219973B (enExample)
IL (3) IL119590A (enExample)
LU (1) LU91279I2 (enExample)
MX (1) MX9205532A (enExample)
NL (1) NL300244I1 (enExample)
NO (3) NO301472B1 (enExample)
NZ (1) NZ244585A (enExample)
PL (4) PL172282B1 (enExample)
PT (1) PT536515E (enExample)
SG (1) SG52361A1 (enExample)
SK (2) SK284826B6 (enExample)
TW (1) TW275616B (enExample)
ZA (1) ZA927607B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
WO1995022529A1 (en) * 1994-02-17 1995-08-24 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US8106225B2 (en) 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
EP2327687A3 (en) 1999-09-14 2012-08-15 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
ATE365710T1 (de) 2000-03-31 2007-07-15 Tufts College 7- und 9-carbamat, harnstoff, thioharnstoff, thiocarbamat und heteroaryl-amino substituierte tetracyclinverbindungen
ATE264295T1 (de) * 2000-05-15 2004-04-15 Paratek Pharm Innc 7-substituierte kondensierte ring-tetrazyclin- verbindungen
ES2271070T3 (es) 2000-07-07 2007-04-16 Trustees Of Tufts College Compuestos de minociclina 9-sustituidos.
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
AU2001271619B2 (en) 2001-03-13 2008-05-15 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
WO2002072506A2 (en) 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
JP2004529927A (ja) * 2001-04-24 2004-09-30 パラテック ファーマシューティカルズ, インク. マラリアの治療のための置換されたテトラサイクリン化合物
EP2332548A1 (en) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of stroke
WO2003055441A2 (en) 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
WO2003057169A2 (en) 2002-01-08 2003-07-17 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
CN1649582A (zh) * 2002-03-08 2005-08-03 帕拉特克药品公司 氨基-甲基取代的四环素类化合物
CN101786991A (zh) 2003-07-09 2010-07-28 帕拉特克药品公司 取代的四环素化合物
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
SI1753713T1 (sl) * 2004-05-21 2017-01-31 President And Fellows Of Harvard College Sinteza tetraciklinov in njihovih analogov
PA8652001A1 (es) 2004-11-05 2006-10-13 Wyeth Corp Metabolitos glucuronidos de tigeciclina y epimeros de los mismos
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
BRPI0615300A2 (pt) * 2005-08-31 2009-07-14 Wyeth Corp composto; composição farmacêutica; método para a preparação, tratamento ou controle de infecções bacterianas em animais de sangue quente; uso de um composto; e método para a preparação de compostos representados pela fórmula (i)
JP2009537139A (ja) 2006-05-15 2009-10-29 パラテック ファーマシューティカルズ インコーポレイテッド 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を制御する方法
AU2008331163B2 (en) 2007-11-29 2014-01-30 Viatris Asia Pacific Pte. Ltd. Phosphonic acid derivates and their use as P2Y12 receptor antagonists
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TW202216656A (zh) 2008-05-19 2022-05-01 美商Prtk Spv2公司 四環素化合物之甲苯磺酸鹽及同素異形體
NZ603568A (en) * 2008-08-08 2014-05-30 Tetraphase Pharmaceuticals Inc C7-fluoro substituted tetracycline compounds
WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
WO2010129057A2 (en) 2009-05-08 2010-11-11 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
ES2654987T3 (es) 2009-08-28 2018-02-15 Tetraphase Pharmaceuticals, Inc. Compuestos de tetraciclina
EP3135289B1 (en) 2010-05-12 2018-12-12 Rempex Pharmaceuticals, Inc. Tetracycline compositions
WO2013013504A1 (zh) * 2011-07-26 2013-01-31 山东亨利医药科技有限责任公司 替加环素衍生物
EP2890673B1 (en) 2012-08-31 2018-11-14 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
US20160143925A1 (en) 2013-11-12 2016-05-26 Galenicum Health S.L. Stable pharmaceutical compositions
CN110582486B (zh) 2016-10-19 2024-01-12 四相制药公司 艾若威四环素的结晶形式

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines

Also Published As

Publication number Publication date
AU2618392A (en) 1993-04-08
LU91279I2 (fr) 2006-12-11
EP0536515B1 (en) 2001-12-19
DE69232302T2 (de) 2002-08-14
HUT63145A (en) 1993-07-28
ES2168254T3 (es) 2002-06-16
CA2079692C (en) 2004-06-08
SK298492A3 (en) 1995-03-08
CZ284159B6 (cs) 1998-08-12
DE122006000058I2 (de) 2007-09-13
DE122006000058I1 (de) 2007-01-18
PL175957B1 (pl) 1999-03-31
NZ244585A (en) 1995-07-26
PL173311B1 (pl) 1998-02-27
PL172282B1 (pl) 1997-08-29
CA2079692A1 (en) 1993-04-05
FI924454L (fi) 1993-04-05
CZ284209B6 (cs) 1998-09-16
EP0536515A1 (en) 1993-04-14
NL300244I2 (nl) 2007-01-02
ZA927607B (en) 1993-04-13
IL119590A (en) 1999-03-12
PT536515E (pt) 2002-05-31
NO923857L (no) 1993-04-05
IL119590A0 (en) 1997-02-18
CN1048240C (zh) 2000-01-12
SK114999A3 (en) 2000-07-11
IL103320A0 (en) 1993-03-15
HU9203110D0 (en) 1992-12-28
ATE211128T1 (de) 2002-01-15
PL176333B1 (pl) 1999-05-31
FI114911B (fi) 2005-01-31
NL300244I1 (nl) 2007-01-02
SK280837B6 (sk) 2000-08-14
MX9205532A (es) 1993-04-01
NO923857D0 (no) 1992-10-02
CL2004001623A1 (es) 2005-06-03
KR930007894A (ko) 1993-05-20
CN1072172A (zh) 1993-05-19
KR100269072B1 (ko) 2000-10-16
JPH05255219A (ja) 1993-10-05
DE69232302D1 (de) 2002-01-31
FI924454A0 (fi) 1992-10-02
NO2006015I1 (no) 2006-11-27
TW275616B (enExample) 1996-05-11
CZ309397A3 (cs) 1998-09-16
JP3186863B2 (ja) 2001-07-11
NO301472B1 (no) 1997-11-03
HK1011348A1 (en) 1999-07-09
NO2017037I1 (no) 2017-08-01
NO2006015I2 (no) 2011-03-14
SG52361A1 (en) 1998-09-28
HU219973B (hu) 2001-10-28
CZ298492A3 (en) 1993-05-12
DK0536515T3 (da) 2002-04-08
AU654049B2 (en) 1994-10-20
DE69232302T4 (de) 2003-02-13
HU211172A9 (en) 1995-11-28
SK284826B6 (sk) 2005-12-01
IL103320A (en) 1998-12-06
NO2017037I2 (no) 2017-08-01
PL296143A1 (en) 1993-05-31

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Legal Events

Date Code Title Description
AN Processing applications according to articles 230 and 231 of law 9279/96: notification of filing an application
HHFK Processing applications according to articles 230 and 231 of law 9.279/96: republication
MT Patent procedure suspended until requirement met - articles 230 and 231 of law 9279/96
FGAN Processing applications according to articles 230 and 231 of law 9.279/96: granting
NB Patent issued - articles 230 and 231 of law 9279/96
B25D Requested change of name of applicant approved