BR0207067A - Método para identificar, isolar e produzir antìgenos para um patógeno especìfico e uso do mesmo - Google Patents
Método para identificar, isolar e produzir antìgenos para um patógeno especìfico e uso do mesmoInfo
- Publication number
- BR0207067A BR0207067A BR0207067-7A BR0207067A BR0207067A BR 0207067 A BR0207067 A BR 0207067A BR 0207067 A BR0207067 A BR 0207067A BR 0207067 A BR0207067 A BR 0207067A
- Authority
- BR
- Brazil
- Prior art keywords
- antigens
- identifying
- antibody
- isolating
- allergen
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 11
- 102000036639 antigens Human genes 0.000 title abstract 11
- 108091007433 antigens Proteins 0.000 title abstract 11
- 244000052769 pathogen Species 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 230000001717 pathogenic effect Effects 0.000 title abstract 3
- 230000000521 hyperimmunizing effect Effects 0.000 abstract 5
- 238000002360 preparation method Methods 0.000 abstract 5
- 210000002966 serum Anatomy 0.000 abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 4
- 239000013566 allergen Substances 0.000 abstract 4
- 241001465754 Metazoa Species 0.000 abstract 2
- 238000010188 recombinant method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
"MéTODO PARA IDENTIFICAR, ISOLAR E PRODUZIR ANTìGENOS PARA UM PATóGENO ESPECìFICO E USO DO MESMO". é descrito um método para identificação, isolamento e produção de antígenos soro-reativos hiperimunes a partir de um patógeno específico, tumor, um alérgeno ou um tecido ou um hospedeiro propenso à auto-imunidade, o referido antígeno sendo adequado para uso em uma vacina para um determinado tipo de animal ou para humanos, o qual compreende as seguintes etapas: - prover uma preparação de anticorpos a partir de uma combinação de plasma do referido determinado tipo de animal ou a partir de uma combinação de plasma humano ou de soros individuais com anticorpos contra os referidos patógenos específicos, tumor, alérgeno ou tecido ou hospedeiro propenso à auto-imunidade; - prover pelo menos uma biblioteca de expressão dos referidos patógenos específicos, tumor, alérgeno ou tecido ou hospedeiro propenso à auto-imunidade; - classificar o referido patógeno em pelo menos uma biblioteca de expressão com a referida preparação do anticorpo; - identificar os antígenos que se ligam aos referidos classificados aos anticorpos da referida preparação de anticorpos; - classificar os antígenos identificados com as preparações de anticorpos a partir do soro individual dos indivíduos com anticorpos contra os referidos patógenos específicos, tumor, alérgeno ou tecido ou hospedeiro propensos à auto-imunidade; - identificar a porção do antígeno soro-reativo hiperimune dos referidos antígenos identificados e nos quais os antígenos soro-reativos hiperimunes se ligam a uma porção relevante das referidas preparações de anticorpos individuais a partir dos referidos soros individuais; e opcionalmente, isolar os referidos antígenos soro-reativos hiperimunes e produzir os referidos antígenos soro-reativos hiperimunes através de métodos químicos ou recombinantes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0013001A AT410798B (de) | 2001-01-26 | 2001-01-26 | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
PCT/EP2002/000546 WO2002059148A2 (en) | 2001-01-26 | 2002-01-21 | A method for identification, isolation and production of antigens to a specific pathogen |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0207067A true BR0207067A (pt) | 2004-06-15 |
Family
ID=3636418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0207067-7A BR0207067A (pt) | 2001-01-26 | 2002-01-21 | Método para identificar, isolar e produzir antìgenos para um patógeno especìfico e uso do mesmo |
Country Status (24)
Country | Link |
---|---|
US (4) | US7968297B2 (pt) |
EP (6) | EP2319861A1 (pt) |
JP (2) | JP2004531476A (pt) |
KR (4) | KR20080107477A (pt) |
CN (2) | CN101492496A (pt) |
AT (2) | AT410798B (pt) |
AU (3) | AU2002247641B8 (pt) |
BR (1) | BR0207067A (pt) |
CA (2) | CA2792244A1 (pt) |
CZ (1) | CZ20032201A3 (pt) |
DE (1) | DE60207194T2 (pt) |
DK (1) | DK1355930T3 (pt) |
ES (1) | ES2252438T3 (pt) |
HU (1) | HUP0402048A3 (pt) |
IL (4) | IL157082A0 (pt) |
IS (1) | IS6895A (pt) |
MX (1) | MXPA03006702A (pt) |
NO (1) | NO20033364L (pt) |
NZ (4) | NZ565349A (pt) |
PL (2) | PL214482B1 (pt) |
RU (1) | RU2289817C2 (pt) |
SK (1) | SK10492003A3 (pt) |
WO (1) | WO2002059148A2 (pt) |
ZA (1) | ZA200305764B (pt) |
Families Citing this family (126)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030036639A1 (en) | 2001-01-03 | 2003-02-20 | Emery Daryll A. | Immunizing compositions and methods of use |
AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
WO2002102829A2 (en) * | 2001-06-15 | 2002-12-27 | Inhibitex, Inc. | Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and staphylococcus aureus |
GB0200865D0 (en) * | 2002-01-16 | 2002-03-06 | Univ Bristol | Method |
GB2387600A (en) * | 2002-04-19 | 2003-10-22 | Pantherix Ltd | Pantothenate kinase |
CA2484335A1 (en) * | 2002-10-03 | 2004-04-15 | Intercell Ag | Use of molecules which interact with the haptoglobin receptor ligand binding |
JP2006520202A (ja) * | 2003-03-04 | 2006-09-07 | インターツェル・アクチェンゲゼルシャフト | ストレプトコッカス・ピオゲネス抗原 |
CA2520868A1 (en) | 2003-03-31 | 2004-10-14 | Intercell Ag | Staphylococcus epidermidis antigens |
EP2314719A1 (en) | 2003-04-15 | 2011-04-27 | Intercell AG | S. pneumoniae antigens |
EP1622933A2 (en) * | 2003-04-22 | 2006-02-08 | Intercell AG | H. pylori antigens |
AU2004235952A1 (en) * | 2003-05-07 | 2004-11-18 | Intercell Ag | Streptococcus agalactiae antigens I + II |
EP2327720A1 (en) | 2003-05-30 | 2011-06-01 | Intercell AG | Enterococcus antigens |
RU2337108C2 (ru) * | 2003-07-24 | 2008-10-27 | Мерк Энд Ко., Инк. | Полипептиды для индукции защитного иммунного ответа против staphylococcus aureus |
US20060188515A1 (en) * | 2003-07-24 | 2006-08-24 | Anderson Annaliesa S | Polypeptides for inducing a protective immune response against staphylococcus aureus |
ATE520709T1 (de) | 2003-09-19 | 2011-09-15 | Epitopix Llc | Campylobacter-polypeptide und verwendungsverfahren |
CN1918176A (zh) | 2004-02-18 | 2007-02-21 | 默克公司 | 用于诱导针对金黄色葡萄球菌的保护性免疫反应的多肽 |
WO2005086663A2 (en) * | 2004-02-27 | 2005-09-22 | Merck & Co., Inc. | Polypeptides for inducing a protective immune response against staphlococcus aureus |
JP2005278537A (ja) * | 2004-03-30 | 2005-10-13 | Dai Ichi Seiyaku Co Ltd | 新規ポリペプチド |
US20070128183A1 (en) * | 2004-04-27 | 2007-06-07 | Intercell Ag | Td antigens |
US7842479B2 (en) | 2004-05-21 | 2010-11-30 | The Board Of Regents Of The University Of Nebraska | Methods for altering acetic acid production and enhancing cell death in bacteria |
JP2008500043A (ja) * | 2004-05-25 | 2008-01-10 | メルク エンド カムパニー インコーポレーテッド | 黄色ブドウ球菌に対する感染防御免疫応答を誘導するためのポリペプチド |
US20090317412A1 (en) * | 2004-06-04 | 2009-12-24 | Alexander Jeffery L | Induction of an immune response against streptococcus pneumoniae polyaccharides |
FR2871237B1 (fr) * | 2004-06-08 | 2011-03-11 | Abag | Nouveaux polypeptides pour la mise en evidence in vitro et la prevention des infections staphylococciques sur protheses articulaires et autres materiels etrangers implantes |
FR2871159A1 (fr) * | 2004-06-08 | 2005-12-09 | Abag Sa | Nouvelles proteines permettant, notamment, la mise en evidence in vitro et la prevention des infections a staphylocoques a coagulase negative |
WO2007018482A2 (en) * | 2004-07-06 | 2007-02-15 | Merck & Co., Inc. | Polypeptides for inducing a protective immune response against staphylococcus aureus |
US20080095792A1 (en) * | 2004-09-17 | 2008-04-24 | Anderson Annaliesa S | Polypeptides For Inducing A Protective Immune Response Against Staphylococcus Aureus |
ES2472441T3 (es) | 2004-09-22 | 2014-07-01 | Glaxosmithkline Biologicals S.A. | Composición inmunog�nica para uso en vacunación contra estafilococos |
WO2007001423A2 (en) | 2004-10-21 | 2007-01-04 | Wyeth | Immunogenic compositions of staphylococcus epidermidis polypeptide and polynucleotide antigens |
CA2583026A1 (en) * | 2004-10-29 | 2006-05-04 | Intercell Ag | Hcv vaccines for chronic hcv patients |
EP1843785B1 (en) | 2005-01-21 | 2016-07-27 | Merck Sharp & Dohme Corp. | Polypeptides for inducing a protective immune response against staphylococcus aureus |
NZ556651A (en) | 2005-01-21 | 2010-05-28 | Epitopix Llc | Yersinia spp. polypeptides and methods of use |
EP1853306B1 (en) | 2005-02-14 | 2016-06-15 | Epitopix, LLC | Polypeptides from staphylococcus aureus and methods of use |
US20080213922A1 (en) * | 2005-04-04 | 2008-09-04 | Chahal Francina C | Method And System For Identification Of Antigen |
WO2006121664A2 (en) * | 2005-05-05 | 2006-11-16 | Merck & Co., Inc. | Polypeptides for inducing a protective immune response against staphylococcus aureus |
US20070003954A1 (en) * | 2005-05-12 | 2007-01-04 | The Board Of Regents Of The University Of Texas System | Protein and antibody profiling using small molecule microarrays |
BRPI0613026A2 (pt) * | 2005-07-14 | 2012-01-03 | Bharat Biotech Int Ltd | composiÇço, fragmento de nucleotÍdeo, constructo de dna recombinante, mÉtodo para produzir proteÍna, composiÇço farmacÊutica e mÉtodo para uso da mesma, formulaÇço, mÉtodo de administrar composiÇço farmacÊutica, mÉtodo de prevenÇço e controle de infecÇÕes associadas a staphylococcus |
US20090317421A1 (en) * | 2006-01-18 | 2009-12-24 | Dominique Missiakas | Compositions and methods related to staphylococcal bacterium proteins |
JP2009531387A (ja) | 2006-03-30 | 2009-09-03 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
GB0610776D0 (en) * | 2006-05-31 | 2006-07-12 | Univ Bath | Novel applications for staphylococcus aureus Sbi protein |
WO2008031133A2 (en) * | 2006-09-15 | 2008-03-20 | Intercell Ag | Borrelia antigens |
US20080102067A1 (en) * | 2006-10-25 | 2008-05-01 | Cook Mark E | Immunogenic composition |
EP1923069A1 (en) | 2006-11-20 | 2008-05-21 | Intercell AG | Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto |
EP1935984A1 (en) * | 2006-12-20 | 2008-06-25 | Unilever N.V. | Screening method for the identification of a preservative |
JP2010516279A (ja) | 2007-01-24 | 2010-05-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 表皮ブドウ球菌に対する防御免疫応答を誘導するためのポリペプチド |
AU2008229453A1 (en) * | 2007-03-19 | 2008-09-25 | Merck Sharp & Dohme Corp. | Polypeptides for inducing a protective immune response against staphylococcus epidermidis |
EP2511291A3 (en) * | 2007-06-18 | 2012-11-07 | Intercell AG | Chlamydia antigens |
US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
WO2009029831A1 (en) | 2007-08-31 | 2009-03-05 | University Of Chicago | Methods and compositions related to immunizing against staphylococcal lung diseases and conditions |
MX2010004143A (es) * | 2007-10-18 | 2010-04-27 | Unilever Nv | Metodo para producir un agente espumante. |
CN101458255B (zh) * | 2007-12-14 | 2013-03-06 | 武汉大学 | 丙型肝炎病毒包膜抗原夹心法试剂盒及检测方法 |
US20090196852A1 (en) * | 2008-02-04 | 2009-08-06 | Watkinson D Tobin | Compositions and methods for diagnosing and treating immune disorders |
US8466167B2 (en) | 2008-03-03 | 2013-06-18 | Irm Llc | Compounds and compositions as TLR activity modulators |
CN101977927A (zh) | 2008-03-17 | 2011-02-16 | 英特塞尔股份公司 | 针对肺炎链球菌保护的肽以及与其有关的组合物、方法和用途 |
WO2009158682A2 (en) * | 2008-06-27 | 2009-12-30 | Watkinson D Tobin | Compositions and methods for diagnosing and treating pathogenic disorders |
US20100015171A1 (en) * | 2008-07-15 | 2010-01-21 | Statens Serum Institute | Vaccines comprising tb 10.4 |
WO2010014304A1 (en) | 2008-07-29 | 2010-02-04 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
EP2344189B1 (en) * | 2008-09-30 | 2018-05-30 | University of Maryland, Baltimore | Protective vaccine against staphylococcus aureus biofilms comprising cell wall-associated immunogens |
EP2341929B1 (en) * | 2008-10-06 | 2017-01-25 | University Of Chicago | Compositions and methods related to bacterial emp proteins |
BRPI0919788A2 (pt) * | 2008-10-16 | 2016-09-06 | Unilever Nv | solução aquosa de hidrofobina contendo antiespumante |
JP2012509665A (ja) | 2008-11-26 | 2012-04-26 | メルク・シャープ・エンド・ドーム・コーポレイション | スタフィロコッカス・アウレウス(staphylococcusaureus)に対する防御免疫応答を誘導するポリペプチド |
JP2012509664A (ja) | 2008-11-26 | 2012-04-26 | メルク・シャープ・エンド・ドーム・コーポレイション | スタフィロコッカス・アウレウス(staphylococcusaureus)に対する防御免疫応答を誘導するポリペプチド |
SG195555A1 (en) | 2008-12-24 | 2013-12-30 | Emd Millipore Corp | Caustic stable chromatography ligands |
US20130243779A1 (en) | 2009-02-05 | 2013-09-19 | Intercell Ag | Peptides protective against e. faecalis, methods and uses relating thereto |
NZ614557A (en) | 2009-03-23 | 2015-03-27 | Epitopix Llc | Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use |
HUE057713T2 (hu) | 2009-04-03 | 2022-05-28 | Univ Chicago | A protein A (SPA) variánsaival kapcsolatos készítmények és módszerek |
EP3263128A3 (en) * | 2009-04-14 | 2018-01-24 | GlaxoSmithKline Biologicals S.A. | Compositions for immunising against staphylococcus aureus |
CA2704702C (en) * | 2009-06-02 | 2018-06-12 | Unilever Plc | Aerated baked products |
CA2765112A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
BRPI1015567A2 (pt) | 2009-06-22 | 2021-08-31 | Wyeth Llc | Composições imunogênicas de antígenos de staphylococcus aureus |
GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
US9408907B2 (en) | 2009-12-15 | 2016-08-09 | Glaxosmithkline Biologicals Sa | Homogenous suspension of immunopotentiating compounds and uses thereof |
WO2011101465A1 (en) | 2010-02-19 | 2011-08-25 | Intercell Ag | Ic31 nanoparticles |
EP2549990A1 (en) | 2010-03-23 | 2013-01-30 | Irm Llc | Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc. |
JP2013523818A (ja) | 2010-04-05 | 2013-06-17 | ザ・ユニバーシティー・オブ・シカゴ | 免疫反応のエンハンサーとしてのプロテインA(SpA)抗体に関連する組成物および方法 |
CN103025352B (zh) * | 2010-05-05 | 2017-07-11 | 纽约大学 | 金黄色葡萄球菌杀白细胞素及其治疗组合物和用途 |
WO2012003474A2 (en) | 2010-07-02 | 2012-01-05 | The University Of Chicago | Compositions and methods related to protein a (spa) variants |
US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
EP2593133A4 (en) | 2010-07-13 | 2014-11-26 | Merck Sharp & Dohme | STAPHYLOCOCCUS AUREUS SURFACE PROTEIN SA1789 AND PROTECTIVE VACCINE BASED ON IT |
US9095540B2 (en) | 2010-09-09 | 2015-08-04 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens |
WO2012065034A1 (en) | 2010-11-12 | 2012-05-18 | Merck Sharp & Dohme Corp. | Enolase peptide conjugate vaccines against staphylococcus aureus |
CN102558316B (zh) * | 2010-12-30 | 2015-07-01 | 上海雅心生物技术有限公司 | 高稳定性的具抗体结合能力的重组蛋白a及其生产 |
US8945588B2 (en) * | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
BR112013032774B1 (pt) * | 2011-06-19 | 2020-05-05 | Univ New York | composições compreendendo proteína luke isolada ou polipeptídeo da mesma, uma proteína lukd isolada ou polipeptídeo da mesma ou sua combinação, bem como seu uso |
MY165115A (en) | 2011-06-19 | 2018-02-28 | Univ New York | Leukotoxin e/d as a new anti-inflammatory agent and microbicide |
EP2773370A4 (en) | 2011-10-31 | 2016-09-28 | Merck Sharp & Dohme | PROTECTIVE VACCINE BASED ON THE STAPHYLOCOCCUS AUREUS PROTEIN SA2451 |
WO2013126006A1 (en) | 2012-02-20 | 2013-08-29 | Swedish Orphan Biovitrum Ab (Publ) | Polypeptides binding to human complement c5 |
WO2013162746A1 (en) | 2012-04-26 | 2013-10-31 | University Of Chicago | Staphylococcal coagulase antigens and methods of their use |
US9376487B2 (en) | 2012-07-10 | 2016-06-28 | Merck Sharp & Dohme Corp. | Protective vaccine based on Staphylococcus aureus SA2493 protein |
RU2526497C2 (ru) * | 2012-10-31 | 2014-08-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Северо-Западный государственный медицинский университет им. И.И. Мечникова" Министерства здравоохарнения и социального развития Российской Федерации | Способ определения генотипов золотистого стафилококка |
SG11201503232TA (en) * | 2012-11-06 | 2015-05-28 | Medimmune Llc | Antibodies to s. aureus surface determinants |
US9873733B2 (en) * | 2012-12-20 | 2018-01-23 | Morphosys Ag. | Anti-staphylococcal antibodies |
CN103965336B (zh) * | 2013-01-29 | 2016-08-10 | 苏州偲聚生物材料有限公司 | 多肽、包含该多肽的检测器件和检测试剂盒 |
CN105188747A (zh) | 2013-02-01 | 2015-12-23 | 葛兰素史密斯克莱生物公司 | 包含toll样受体激动剂的免疫组合物的皮内递送 |
RU2639527C2 (ru) * | 2013-04-25 | 2017-12-21 | ЭбТЛАС КО., Лтд. | Способ очистки белка, включенного в саморасщепляющуюся кассету, и его применение |
WO2015028558A1 (en) * | 2013-08-28 | 2015-03-05 | Swedish Orphan Biovitrum Ab (Publ) | Stable polypeptides binding to human complement c5 |
TR201911279T4 (tr) | 2013-08-28 | 2019-08-21 | Affibody Ab | Mutasyona uğramış bir yapı iskelesine sahip polipeptidlerin bağlanması. |
CN104558196A (zh) * | 2013-10-15 | 2015-04-29 | 温州医科大学 | 基于HBcAg载体的沙眼衣原体主要外膜蛋白表位疫苗及其用途 |
RU2542396C1 (ru) * | 2013-11-06 | 2015-02-20 | Федеральное бюджетное учреждение науки "Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека | Способ и набор для ускоренной лабораторной диагностики коклюшной инфекции |
EP4227685A3 (en) * | 2013-12-03 | 2024-02-28 | Evaxion Biotech A/S | Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus |
CN103694323B (zh) * | 2013-12-09 | 2017-01-18 | 成都欧林生物科技股份有限公司 | 金黄色葡萄球菌MntC重组蛋白及其制备方法和应用 |
US10100093B2 (en) | 2013-12-31 | 2018-10-16 | Epitopix Llc | Polypeptides and immunizing compositions containing Burkholderia polypeptides and methods of use |
JP6634444B2 (ja) * | 2014-06-30 | 2020-01-22 | マードック チルドレンズ リサーチ インスティテュート | ヘリコバクター治療 |
CN104569386B (zh) * | 2014-12-10 | 2016-05-11 | 中国水产科学研究院淡水渔业研究中心 | 一种罗非鱼源无乳链球菌elisa快速检测试剂盒及其检测方法 |
MX2017007204A (es) | 2014-12-17 | 2017-08-28 | Hoffmann La Roche | Reaccion enzimatica en un solo recipiente para conjugacion de polipeptido doble en un solo paso usando sortasa. |
WO2016197071A1 (en) | 2015-06-05 | 2016-12-08 | New York University | Compositions and methods for anti-staphylococcal biologic agents |
JP6998863B2 (ja) | 2015-09-25 | 2022-02-04 | エフ.ホフマン-ラ ロシュ アーゲー | 深共融溶媒におけるソルターゼaを利用したアミド基転移 |
CN108138204B (zh) | 2015-09-25 | 2021-12-31 | 豪夫迈·罗氏有限公司 | 使用分选酶a生产硫酯的方法 |
EP3353291B1 (en) | 2015-09-25 | 2021-06-09 | F. Hoffmann-La Roche AG | Novel soluble sortase a |
AU2016359722B2 (en) | 2015-11-27 | 2020-09-17 | Enantis S.R.O. | Thermostable FGF2 polypeptide, use thereof |
US10166280B2 (en) | 2016-06-08 | 2019-01-01 | Epitopix, Llc | Polypeptides and immunizing compositions containing Bacillus polypeptides and methods of use |
US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
US10504742B2 (en) * | 2017-05-31 | 2019-12-10 | Asm Ip Holding B.V. | Method of atomic layer etching using hydrogen plasma |
WO2018237010A2 (en) * | 2017-06-20 | 2018-12-27 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | VACCINE COMPOSITIONS AGAINST STREPTOCOCCUS AND THEIR METHODS OF USE |
US11458151B2 (en) | 2018-02-12 | 2022-10-04 | Inimmune Corporation | Toll-like receptor ligands |
US10905738B2 (en) | 2018-07-05 | 2021-02-02 | Biozeus Desenvolvimento De Produtos Biofarmacêuticos | Synthetic peptides, prodrugs, pharmaceutical compositions and uses |
RU2689161C1 (ru) * | 2018-10-04 | 2019-05-24 | Федеральное бюджетное учреждение науки "Казанский научно-исследовательский институт эпидемиологии и микробиологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека | Способ получения бактериальных антигенов |
CN111110838A (zh) * | 2019-12-24 | 2020-05-08 | 华南师范大学 | 一种罗非鱼无乳链球菌疫苗及其制备方法 |
CN111808977B (zh) * | 2020-07-23 | 2023-06-27 | 清华大学深圳国际研究生院 | 一种由snp所引起利福平类抗生素耐药的抗性基因的特异性引物的设计方法及检测方法 |
CA3198924A1 (en) | 2020-11-04 | 2022-05-12 | Eligo Bioscience | Phage-derived particles for in situ delivery of dna payload into c. acnes population |
KR102281369B1 (ko) * | 2021-04-07 | 2021-07-22 | 씨제이제일제당 (주) | 신규한 디히드로리포일 아세틸기전이효소 변이체 및 이를 이용한 l-발린 생산 방법 |
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Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69012318T2 (de) * | 1989-03-09 | 1995-03-09 | Praxis Biolog Inc | Impfstoffe gegen hämophilus influenzae. |
US5980908A (en) * | 1991-12-05 | 1999-11-09 | Alfa Laval Ab | Bacterial cell surface protein with fibronectin, fibrinogen, collagen and laminin binding ability, process for the manufacture of the protein and prophylactic treatment |
US5456907A (en) | 1992-01-10 | 1995-10-10 | Helene Curtis, Inc. | Cysteamine permanent wave composition and method |
US5700928A (en) * | 1995-10-16 | 1997-12-23 | Smithkline Beecham, P.L.C. | Polynucleotide encoding saliva binding protein |
US6737248B2 (en) * | 1996-01-05 | 2004-05-18 | Human Genome Sciences, Inc. | Staphylococcus aureus polynucleotides and sequences |
CO4600681A1 (es) | 1996-02-24 | 1998-05-08 | Boehringer Ingelheim Pharma | Composicion farmaceutica para la modulacion inmunitaria |
US6380370B1 (en) * | 1997-08-14 | 2002-04-30 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics |
JP2001526054A (ja) * | 1997-12-05 | 2001-12-18 | インターツェル・ビオメディツィーニシェ・フォルシュングス− ウント・エントヴィックルングス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 組合せライブラリーをスクリーニングするための方法および細胞 |
DE19803453A1 (de) | 1998-01-30 | 1999-08-12 | Boehringer Ingelheim Int | Vakzine |
WO1999057312A1 (en) * | 1998-04-30 | 1999-11-11 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | New method for the selection of clones of an expression library involving rearraying |
EP1090111A1 (en) * | 1998-06-25 | 2001-04-11 | Institut Pasteur | Exhaustive analysis of viral protein interactions by two-hybrid screens and selection of correctly folded viral interacting polypeptides |
US6610836B1 (en) * | 1999-01-29 | 2003-08-26 | Genome Therapeutics Corporation | Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics |
AT407643B (de) * | 1999-02-01 | 2001-05-25 | Intercell Biomedizinische Forschungs & Entwicklungs Gmbh | Verfahren zur selektion und herstellung von vakzin- und diagnostika-präparationen |
US6936258B1 (en) * | 1999-03-19 | 2005-08-30 | Nabi Biopharmaceuticals | Staphylococcus antigen and vaccine |
DE60044514D1 (de) * | 1999-05-05 | 2010-07-15 | Phylogica Ltd | Isolierung von biologischen Modulatoren aus Bibliotheken mit biologisch vielvältigen Genfragmenten |
IL146544A0 (en) * | 1999-08-06 | 2002-07-25 | Ivigene Corp | Microbial polynucleotides expressed during infection of a host |
AT408721B (de) | 1999-10-01 | 2002-02-25 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung enthaltend ein antigen |
EP1268774A2 (en) * | 2000-03-21 | 2003-01-02 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in prokaryotes |
DE60100814T2 (de) | 2000-06-08 | 2004-07-01 | Intercell Biomedizinische Forschungs- Und Entwicklungs Gmbh | Immunstimulierende oligodeoxynukleotide |
GB0014907D0 (en) * | 2000-06-20 | 2000-08-09 | Univ Sheffield | Antigenic polypeptides |
AU2001289813B2 (en) | 2000-08-17 | 2005-07-28 | Intercell Ag | A vaccine which comprises at least one antigen and a cathelididin derived antimicrobial peptide or a derivative thereof |
AT410635B (de) | 2000-10-18 | 2003-06-25 | Cistem Biotechnologies Gmbh | Vakzin-zusammensetzung |
AT410798B (de) * | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
WO2002077183A2 (en) | 2001-03-21 | 2002-10-03 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
GB0107661D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
WO2002102829A2 (en) | 2001-06-15 | 2002-12-27 | Inhibitex, Inc. | Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and staphylococcus aureus |
CA2453937C (en) | 2001-08-02 | 2013-05-14 | University Of Sheffield | Antigenic polypeptides |
RU2337108C2 (ru) | 2003-07-24 | 2008-10-27 | Мерк Энд Ко., Инк. | Полипептиды для индукции защитного иммунного ответа против staphylococcus aureus |
EP1734615B1 (en) | 2005-06-13 | 2008-10-08 | Research In Motion Limited | Electrical connector and system for a component in an electronic device |
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