CN1649894A - 鉴定,分离及生产特异性病原体抗原的方法 - Google Patents
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Abstract
本发明涉及源自特异性病原体,肿瘤,易于引起
自身免疫反应的变态反应原或组织,或宿主的超免疫血清反应
性抗原的鉴定,分离和制备方法。这种抗原适用于给定种类的
动物或人类的疫苗,该方法特征如下:提供来自该给定动物的
血浆库或来自人类血浆库或个体的血清的抗体制备物,其中含
有针对所述特异性病原体、肿瘤、或倾向于引起自身免疫反应
的变态反应原、或组织、或宿主的抗体,提供至少一种上述特
异性病原体、肿瘤、或倾向于引起自身免疫反应的变态反应原、
或组织、或宿主的表达文库,用上述抗体制备物筛选上述至少
一种表达文库,鉴定在该筛选中与该抗体制备物中的抗体相结
合的抗原,使用来自个体的个体血清的个体抗体制备物筛选所
鉴定的抗原,该个体含有针对特异性病原体、肿瘤、或倾向于
引起自身免疫反应的变态反应原、或组织、或宿主的抗体,鉴
定所述已鉴定出的抗原的超免疫血清反应性抗原部分,且该超
免疫血清反应性抗原结合源自该个体血清的个体抗体制备物
的相关部分;以及可选分离所述超免疫血清反应性抗原,并通
过化学或重组方法生产所述超免疫血清反应性抗原。
Description
本发明涉及鉴定,分离及生产特异病原体抗原的方法,以及适用于给定种类的动物或人类疫苗的新抗原。
疫苗与其它医疗干涉相比,挽救了更多的生命(和资源)。由于全世界范围的疫苗接种计划,许多致命性疾病的发生率已经大大降低。尽管疫苗对许多疾病例如白喉,百日咳,麻疹,破伤风等有效,但是对于许多传染性疾病,包括多数病毒感染如HIV,HCV,CMV和其它病毒,还缺乏有效的疫苗。对于每年夺走数百万患者生命的其它疾病,如疟疾和癌症,也没有有效的疫苗。另外,抗生素耐受的细菌和微生物的快速产生使得使用疫苗进行替换治疗成为合理的选择。最后,世界上除心血管疾病,癌症或创伤之外,传染性疾病是引起死亡和残疾的最大原因,这些说明对疫苗有着巨大的需求。
许多已经构建的疫苗由减活的生物体组成,但是存在其向致命的野生型逆转的风险。特别是在免疫妥协的宿主中,这就可能成为威胁生命的事件。另外,许多疫苗由病原体衍生的抗原与能够引起或增强机体对这些抗原的免疫反应的化合物(这些化合物通常叫佐剂)组合而成,因为这些亚单位疫苗本身一般没有活性。
然而毫无疑问,上述疫苗都是有价值的药物治疗。但是其缺点是由于其结构复杂性,会引起严重的副作用,例如疫苗的抗原部分同接种个体的细胞所表达的分子现出交叉反应。另外许多管理性权威机构如WHO,FDA以及它们的欧洲同行,对疫苗组合物的特异性及引起免疫反应的机理的许多要求难以满足。
一些广泛使用的疫苗是全细胞疫苗(减毒的细菌或病毒(如Bacille Calmette-Guerin(BCG)(肺结核))),麻疹,腮腺炎,风疹,萨宾疫苗;灭活的微生物或病毒如百日咳和沙克疫苗),亚单位疫苗(如类毒素(白喉和破伤风)),荚膜多糖(如B型流感病毒),酵母重组亚单位(如乙型肝炎表面蛋白)。
疫苗包括不同抗原的所有种类。抗原例子是经过彻底灭活的生物体,如失活的病毒或细菌,真菌,原生细胞,或甚至癌症细胞。抗原可由这些微生物或组织的碎片,蛋白或以其最简单的形式,多肽构成。抗原被免疫系统以糖基化的蛋白或肽而识别,并可能也包含多糖或脂类。短肽也可被使用,因为例如细胞毒T细胞可以识别的抗原通常形式为长8-11个氨基酸的肽与主要组织相容性复合物相连接。B细胞能够识别短至4-5个氨基酸的线性抗原决定簇,以及三级结构(构象表位)。为了能够得到持续的抗原特异的免疫性反应,需佐剂来引发免疫级联反应,这涉及到免疫系统所有必需的细胞。佐剂不受其作用方式限制,主要作用于所谓的抗原呈递细胞(APC)。这些细胞通常首先遇到抗原,并将加工过的或未更改的抗原呈递给免疫效应细胞。中间的细胞类型也可能起作用。在生产性免疫反应中只有具有合适特异性的效应子细胞才能被激活。佐剂也可原地保留抗原和共同注入的其它因子。而且,佐剂可作为其它免疫细胞的化学吸引剂,或者局部或全身地作为免疫系统的刺激剂来起作用。
抗原呈递细胞属于先天免疫系统,它作为宿主暴露于微生物环境之后对感染进行早期限制的第一道防线而进化产生。先天免疫系统的细胞识别它们靶点上表达的模式或相对非特异性的结构,而不是那些获得性免疫系统所识别的复杂的,特异性的结构。先天免疫系统细胞的例子是巨噬细胞和树状细胞,还有粒细胞(如嗜中性粒细胞),自然杀伤细胞及其它。相反,获得性免疫系统的细胞识别特异性的抗原性结构,包括肽,对于T细胞的情况,和肽及三维结构,对于B细胞的情况。与先天免疫系统相比,获得性免疫系统更特异,更复杂,当重复暴露于给定病原体/抗原时得到强化。从系统发育学上来讲,先天免疫系统更古老,已见于十分原始的生物中。然而,先天免疫系统在暴露于抗原的初始阶段作用相当关键,除了去包含病原体,先天免疫系统的细胞,即APC,引发获得性免疫系统的细胞,并由此引发特异性免疫反应,而清除入侵者。总而言之,先天免疫系统特别是APC在免疫反应的诱发阶段起非常重要的作用,通过a)由原始的模式识别系统包含感染物;b)为引发获得性免疫细胞,导致特异性免疫反应和记忆,结果清除入侵的病原体或其它目标物。这些机理对于清除和包被肿瘤细胞可能也是非常重要。
这些疫苗所用的抗原通常经过随机挑选或以可利用性的便易性来挑选。需要有效鉴定给定病原体抗原或——优选——给定病原体的几乎全套实际(临床)相关的全部抗原。这些抗原可以优选作为疫苗的候选抗原。
本发明的目的之一是符合这些要求并提供方法而由此提供这种抗原,及由此可以用给定血清作抗体源鉴定给定病原体的几乎全套抗原。这种方法也应适用于那些对普通药物和疫苗很快产生抗性的迅速变异的病原体。这种方法还应适用于鉴定和分离肿瘤抗原,变态反应原,自体免疫抗原。
因此,本发明提供了鉴定,分离和制备源自特异性病原体、肿瘤、易于引起自身免疫反应的变态反应原或组织、或宿主的超免疫血清反应性抗原的方法。这种抗原适用于给定种类的动物或人类的疫苗,所述方法表征为以下步骤:
-提供来自给定动物的血浆库或来自人类血浆库或个体的血清的抗体制备物,其中含有针对所述特异性病原体、肿瘤、或倾向于引起自身免疫反应的变态反应原、或组织、或宿主的抗体,
-提供至少一种上述特异性病原体、肿瘤、或倾向于引起自身免疫反应的变态反应原、或组织、或宿主的表达文库,
-用上述抗体制备物筛选上述至少一种表达文库,
-鉴定在筛选中与抗体制备物中的抗体相结合的抗原,
-使用来自个体的个体血清制备的个体抗体筛选所鉴定的抗原,该个体含有针对特异性病原体、肿瘤、或倾向于引起自身免疫反应的变态反应原、或组织、或宿主的抗体,
-鉴定所述特异性抗原的超免疫血清反应性抗原部分,且该超免疫血清反应性抗原在与源自个体血清的个体抗体制备物的相关部分相结合;以及
-可选分离所述超免疫血清反应性抗原,并通过化学或重组方法生产所述超免疫血清反应性抗原。
如果使用本发明的方法,在病原体/抗原的鉴定过程中,至少筛选了三种不同的表达文库,那么这种方法总的来说也适于用给定血清作抗体源鉴定给定病原体的几乎全套超免疫血清反应性抗原。本发明因此也涉及鉴定,分离和制备特异病原体的几乎全套超免疫血清反应性抗原的方法,该抗原适用于已知种类牲畜及人类的疫苗,该方法表征为以下步骤:
-提供来自给定动物的血浆库或来自人类血浆库或个体的血清的抗体制备物,其中含有针对所述特异性病原体的抗体,
-提供至少三种该特异性病原体的表达文库,
-用所述抗体制备物筛选所述至少三种不同的表达文库,
-鉴定在所述至少三次筛选中与抗体制备物中的抗体相结合的抗原,
-使用来自个体的个体血清制备的个体抗体筛选所鉴定的抗体,该个体含有针对所述特异性病原体的抗体,
-鉴定所述特异性抗原的超免疫血清反应性抗原部分,且该超免疫血清反应性抗原与源自所述个体血清的所述个体抗体制备物的相关部分相结合,
-重复所述筛选和鉴定步骤至少一次,
-比较在初始筛选和鉴定步骤中鉴定的超免疫血清反应性抗原和在重复的筛选及鉴定步骤中鉴定的超免疫血清反应性抗原,
-如果仅在重复的筛选及鉴定步骤中就鉴定出大于5%的超免疫血清反应性抗原,则继续重复筛选及鉴定步骤直到在进一步重复的筛选及鉴定步骤中仅鉴定出小于5%的超免疫血清反应性抗原为止,这样得到特异性病原体的全套超免疫血清反应性抗原;以及
-可选分离所述超免疫血清反应性抗原,并通过化学或重组方法生产所述超免疫血清反应性抗原。
根据本发明的方法主要包括三个必要部分,即1.鉴定含针对给定病原体的特异性抗体的超免疫血清源,2.用合适的抗体制备物筛选合适的表达文库,其中选择候选抗原(或这种抗原的抗原性片段),及3.在第二轮筛选中,其中根据与来自个体血清的个体抗体制备物的相关部分相结合的能力鉴定超免疫血清反应性抗原,从而表明这些抗原具有实际相关性,且不仅具有超免疫血清反应性,还具有广泛的免疫原性(也就是说许多个体血清都与给定抗原反应)。通过本方法有可能提供给定病原体的一套抗原,其对所选病原体和所选血清来说实际上几乎完备。因此,本方法可以排除错误的候选抗原或病原体的不全套抗原的偏差。
在本发明的意义中给定病原体的抗原套的完备性当然依靠在本方法中使用的表达文库的完备性和测试的血清样本的质量和数量(个体血浆/血清的数目),这两者都与文库的代表性及表达系统的实用性有关。因此,本方法优选的实施方案的特征在于至少所述一个所述表达文库选自核糖体展示文库,细菌表面文库和蛋白质组。
本发明中使用的血清样本通过对一系列给定病原体的已知的抗原性化合物来检验,如多糖,脂类和细胞壁,细胞膜,细胞质中的蛋白类成分,及分泌产物。优选,使用三个完全不同的血清样本,1.具有稳定的抗体构成(repertoire):正常成年人,临床表现健康,其克服了先前的遭遇的给定病原体,或者为无急性疾病和症状的当前携带者,2.具有由存在该病原生物体而急性引发的抗体:具有不同表现的急性疾病患者(如金黄色葡萄球菌脓血症或创伤感染等),3.完全没有特异性抗体(作为阴性对照):5-8个月大的婴儿,其在出生5-6个月后失去了母体传递的免疫球蛋白。这些血清必须与多种病原体特异的抗原反应,来考察对给定病原体(细菌,真菌,寄生虫或其它)的超免疫性及在根据本发明的筛选方法中的相关性。
在根据本发明鉴定全套抗原的抗原鉴定程序中,优选所述至少三种不同的表达文库是至少核糖体展示文库,细菌表面文库和蛋白质组。已知尽管所有表达文库可能都是完备的,但是由于每种不同表达文库优选的表达属性不同,在抗原鉴定程序中只使用一或两种表达文库还不足以得到全套抗原。因此虽然使用一或两种表达文库可能得到超免疫血清反应性抗原,但这在许多情况中可能最终不能鉴定全套的超免疫血清反应性抗原。当然,根据本发明的‘完全’一词并不代表理论上的最大值,而的确是实际的完备性,也就是说至少鉴定出给定病原体的95%的实际相关的抗原或抗原决定簇。实际相关性由此定义为在患者群体中针对给定抗原的抗体的发生。
根据本发明,血清库,或血浆级分或其它收集的包含抗体的体液也都为“血浆库”。
本发明使用的表达文库应至少允许表达全部的潜在抗原,如给定病原体的所有表面蛋白。用根据本发明的表达文库,提供病原体的至少一套潜在抗原,该套优选为由病原体基因组(即如实施例2所述的基因组文库)编码的(多)肽的完整的理论套(complement),且其表达于重组宿主(见例3)或体外(见例4)。这套潜在的抗原还可以是蛋白制备物,对于细胞外病原体的情况,优选含有来自在特定生理条件下生长的所述病原体的表面蛋白的蛋白制备物(见例5)。虽然基因组的方法可能包含全套抗原,但后一种方法的优点是包含在其天然状态的蛋白,也就是说包括例如翻译后修饰或加工过形式的这些蛋白,而这些修饰或加工从其DNA序列不能明显得到。来自病原体,肿瘤,倾向于引起自身免疫反应的变态反应原、或组织、或宿主的这些或其它的潜在抗原套在此都称为“表达文库”。不同种类的表达文库在本发明中都可应用。例如Ausubel等人1994年给出了合适的例子。特别优选的表达文库以重组形式代表病原体遗传设置的展示,如以体外翻译技术,例如核糖体展示或原核表达系统,例如细菌表面表达文库或重构特定生理状态下给定病原体的特异性生理表达状态的文库,如蛋白质组。
核糖体展示是重组DNA技术中的一个成熟方法,对本发明来讲适用于各种特异性的病原体(Schaffitzel等,1994)。细菌表面展示文库的代表是细菌宿主的重组文库,其在,例如细菌宿主膜的所选外膜蛋白上展示给定病原体的一套(全部)所表达的肽序列(Georgiou等人,1997)。除了在外膜蛋白上展示肽或蛋白序列外,其他细菌展示技术,例如噬菌体展示技术和通过外运蛋白表达等,也是优选的细菌表面表达文库(Forrer等,1999;Rodi和Makowski,1993;Georgiou等,1997)。
在根据本发明的方法进行第一筛选的抗原制备物可来自包含针对给定病原体的抗体的任何来源。优选,如果血浆库用作抗体制备物的来源,那么人血浆库应该选择那些经受过或正在经受该病原体感染的捐赠者的血浆库。尽管原则上这样选择血浆或血浆库在例如超免疫球蛋白制备物的生产过程是标准技术,但令人吃惊的是这种技术在本发明优选的实施方案中具有特别说明的这些作用。
优选,表达文库是病原体基因组表达文库,或者mRNA文库。优选这些基因组或mRNA文库是完备的基因组或mRNA表达文库,意指它们包含至少一次给定病原体所有可能表达的蛋白,肽及肽片段。优选这种基因组表达文库展示冗余度为至少二倍,更优选至少五倍,尤其是至少十倍。
优选,根据本发明的方法包括用抗体制备物筛选至少核糖体展示文库,细菌表面展示文库和蛋白质组并鉴定在至少两种,优选全部筛选中与抗体制备物中的抗体相结合的抗原。无论其表达方式如何,这些抗原被认为很适合作为超免疫原性抗原。优选至少两种筛选应至少包括蛋白质组,这是因为蛋白质组代表的抗原总是包含翻译后修饰、加工等的天然表达的蛋白,这些修饰和加工不能直接从DNA序列看出。
根据本发明的方法可以适用于任何给定病原体。因此,优选的病原体选自细菌,病毒,真菌和原生动物病原体。根据本发明的方法也适用于癌症,即,鉴定肿瘤相关抗原,且适用于鉴定变态反应原或自身免疫疾病相关的抗原。当然,重组方法对于基因组小,或表达蛋白数量相对较少的病原体来说尤其特别简单(例如细菌或病毒病原体);而对于具有庞大基因组的复杂(真核)生物来说,就比较复杂。然而使用根据本发明的方法可以对较高等的生物病原体的大基因组文库进行良好的分析,与已知的鉴定适合抗原的方法相比,本发明所用方法至少更快捷,更可靠。
优选的被分析或被提取抗原的病原体分别包括人免疫妥协病毒(HIV)、甲肝病毒(HAV)、乙肝病毒(HBV)、丙肝病毒(HCV)、痨氏肉瘤病毒(RSV)、非洲淋巴细胞瘤病毒(EBV)、流感病毒(IV)、轮状病毒(RV)、金黄色葡萄球菌(S.aureus)、表皮葡萄球菌(表皮葡萄球菌)、肺炎衣原体(Chlamydia pneumoniae)、砂眼衣原体(Chlamydia trachomatis)、结核分支杆菌(Mycobacterium tuberculosis)、麻风分支杆菌(Mycobacteriumleprae)、肺炎链球菌(Streptococcus pneumoniae)、酿脓链球菌(Streptococcus pyogenes)、无乳链球菌(Streptococcusagalactiae)、粪肠球菌(Enterococcus faecalis)、炭疽芽孢杆菌(Bacillus anthracis)、霍乱弧菌(Vibrio cholerae)、布氏疏螺旋体(Borrelia burgdorferi)、疟原虫属(Plasmodiumsp);真菌疾病如Pneumocystis carinii、曲霉属(Aspergillussp.)、隐球酵母属(Cryptococcus sp.)、白色假丝酵母(Candidaalbicans)或寄生感染如蛔虫病(似引蛔线虫Ascarislumbricoides)和绦虫病(Taenia saginata)。根据本发明的方法最适用于细菌、寄生虫和假丝酵母。
本发明的方法选择金黄色葡萄球菌作为模型生物来演示本发明方法的适用性和有效性。实施例特别清楚地表明,本发明方便地适用于所有潜在病原体,特别是上述列举的病原体。
令人吃惊的是根据本发明的方法可以对给定病原体进行高效快速的生物筛选,特别是患者抗体库仅有小部分针对给定病原体,甚至在患者已经有效地击败了该病原体的状态中。在本发明的过程中发现,尤其是在进行金黄色葡萄球菌的实施例中,只有1-2%的患者抗体对金黄色葡萄球菌具有较高的效价,它们是实际针对金黄色葡萄球菌的抗体。而且,在这1%的特异性抗体中大于70%的抗体作用于非蛋白抗原如磷壁酸,而只有0.1%或更少的抗体针对蛋白类抗原。
使用重组表达文库,特别是核糖体展示文库和细菌表面展示文库的一个优点是,鉴定出的超免疫血清反应性抗原可以通过表达所筛选和选择的表达超免疫血清反应性抗原的克隆的编码序列来立即生产,而不需进一步的重组DNA技术及必要的克隆步骤。
因此根据本发明方法获得的超免疫血清反应性抗原可以在其生产(在第二次筛选步骤过程中)出来之后,例如由表达文库平台表达后,就直接制成药物制剂,优选添加药学可接受的载体和/或赋形剂。
优选,包含超免疫血清反应性抗原的药物制剂是预防或治疗对其筛选抗原的特异性病原体感染的疫苗。
这些药物制剂可含有任何适当的辅助物质,如缓冲物、稳定剂、以及进一步的活性成分,特别是已知与疫苗生产相联系的成分。
根据本发明的超免疫血清反应性抗原的优选载体或赋形剂为免疫刺激性化合物,其可以进一步刺激针对该种超免疫血清反应性抗原的免疫反应。优选在根据本发明的药物制剂中的免疫刺激性化合物选自聚阳离子物质,特别是聚阳离子肽、免疫刺激性的脱氧核苷、明矾(alumn)、弗氏完全佐剂、弗氏不完全佐剂、刺激神经组织的化合物,特别是人生长激素,或其组合。
根据本发明所用的聚阳离子化合物可以是表现根据专利WO97/30721的特征作用的任何聚阳离子化合物。优选聚阳离子化合物选自碱性多肽、有机聚阳离子、碱性聚合氨基酸或它们的混合物。这些聚合氨基酸须有链长至少4个氨基酸残基(见1983年Golgman等人所述的吞噬作用激素)。特别优选的物质例如多聚赖氨酸、多聚精氨酸和在大于8个,特别是大于20个氨基酸残基的范围内含有超过20%,特别是超过50%的碱性氨基酸的多肽或其混合物。其他优选的聚阳离子及其药物制剂在专利WO 97/30721(例如,多聚乙烯基亚胺)和专利WO 99/38528中都有介绍。优选,这些多肽包括20-500个氨基酸残基,尤其是包含30-200个氨基酸残基。
这些聚阳离子化合物可以通过化学或重组方法产生,也可以衍生自天然来源。
阳离子(多)肽可具有微生物抗性,具有1999年Ganz等人以及Hancock综述的属性。这些(多)肽可以源自原核生物、或动物、或植物来源,或可以通过化学或重组的方法生产(1998年Andreu等人,1999年Ganz等,1998年Simmaco等)。这些肽也可能属于防御素(1999年Ganz,1999年Ganz等人)。这些肽的序列可以在例如抗微生物序列的数据库中找到,网址如下:http://www.bbcm.univ.trieste.it/-tossi/pag2.html这种宿主防御肽或防御性物质(defensive)也是根据本发明的聚阳离子聚合物的优选形式。总的来说,作为终产物允许激活(或者下调)获得性免疫系统,优选通过APC介导(包括树状细胞)的化合物都用作聚阳离子聚合物。
在本发明中特别优选用作聚阳离子物质的是衍生自抗微生物肽或其衍生物的卡萨里斯丁(cathelicidin)(国际专利申请PCT/EP01/09529,在此作为参考),尤其是源于哺乳动物卡萨里斯丁的抗微生物肽,优选来自人、牛、鼠。
源于天然产物的聚阳离子化合物,包括HIV-REV或HIV-TAT(衍生的阳离子肽,antennapedia肽,脱乙酰几丁质或其它几丁质衍生物),或者通过生物化学或重组生产衍生自这些肽或蛋白的其他肽。其他优选的聚合阳离子化合物是cathelin及其类似物或相关物质。例如,鼠cathelin是氨基酸序列为NH2-RLAGLLRKGGEKIGEKLKKIGOKIKNFFQKLVPQPE-COOH的肽,其。cathelin的相关物及衍生物包含全部或部分cathelin序列,具有至少15-20个氨基酸残基。其衍生物包括天然氨基酸由20种标准氨基酸以外的氨基酸的取代或修饰。而且,进一步的阳离子残基可以被引入到这样的cathelin分子中。这些cathelin分子优选结合抗原。令人惊奇的是在没有添加额外的佐剂时这些cathelin分子也可作为有效的佐剂。因此在有或没有额外的免疫刺激物时,有可能将这些Cathelin分子用作疫苗制剂的有效佐剂。
根据本发明所用的另一种优选的聚阳离子物质是合成的肽,包括至少两个KLK基元,其由3-7个疏水氨基酸的连接物所分开(国际专利申请PCT/EP01/12041,此处作为参考)。
免疫刺激性脱氧核苷酸是例如天然或人工合成的包含CpG DNA、源于无脊椎动物的短链DNA、或形式为在一定碱基结构中包含非甲基胞嘧啶-鸟嘌呤二核苷酸(CpG)的寡核苷酸(ODN)(1995年Krieg等),及如专利WO 01/93905中记载的含次黄嘌呤核苷的寡聚核苷酸。
专利WO 01/24822中记载了例如与聚阳离子物质相结合的刺激神经组织的化合物。
根据优选的实施方案,进行第二轮筛选的个体抗体来源于给定病原体的急性感染的患者,特别是那些对该给定病原体的抗体效价高于所测人(患者或携带者)血清的某个最低水平的患者,例如抗体效价高于80%,优选高于90%,尤其高于95%。在第二轮筛选中使用这样高效价的个体抗体制备物允许对该给定病原体高选择性鉴定超免疫血清反应性抗原。
用个体抗体制备物(其也可为所选的血清)进行第二轮筛选允许从来自第一轮的所有侯选抗原中选择性鉴定超免疫血清反应性抗原是很重要的。因此,优选至少10种个体抗体制备物(也就是说,抗体制备物(例如血清)来自至少10个不同的被所选病原体感染的患者)用于在第二轮筛选中鉴定抗原。当然也使用少于10种个体制备物,但是所用个体抗体准备物的数目少可能使得该步筛选的选择性不够最优化。另一方面,如果超免疫血清反应性抗原(或其抗原性片段)在至少10种个体抗体制备物中被识别,优选至少30种、尤其至少50种,那么对于适当的识别,这种超免疫血清反应性抗原的鉴定就具有足够的选择性。超免疫血清反应性可以用尽可能多的不同个体制备物来检验(例如用多于100甚至多于1000)。
因此,根据本发明方法的超免疫血清反应性抗体制备物的相关部分为至少10种,优选至少30个、尤其至少50种个体抗体制备物。或者(或结合)超免疫血清反应抗原在第二轮筛选中,用全部个体抗体制备物的至少20%,优选至少30%、尤其至少40%所鉴定。
根据本发明的优选实施方案,用于第二轮筛的个体抗体制备物的来源血浆(或用作抗体制备物的血清),以其抗特异病原体的效价而筛选(例如抗这种病原体制备物,如溶菌液,细胞壁成分和重组蛋白)。优选,当在ELISA中以全部生物体(总溶菌液或所有细胞)作为抗原时,一些血浆的筛选条件是总IgA效价大于4000U,尤其大于6000U,和/或者IgG效价大于10000U,尤其大于12000U(U=单位,由一定稀释度下OD405nm读数计算出)。根据本发明,总Ig效价大于800-1000U的个体蛋白特别优选用于筛选超免疫血清反应性抗原尽因为总效价。这些个体蛋白的清单(statement)可由图9得来。
根据本发明的说明实施例,其也为优选实施方案,给定病原体是葡萄球菌病原体,特别是金黄色葡萄球菌和表皮葡萄球菌。葡萄球菌是理想的病原体,它可以引起小至轻度感染重至威胁生命的疾病。在众多葡萄球菌中,至少有三种与人类疾病一般相关,分别是金黄色葡萄球菌、表皮葡萄球菌和稀有的腐生葡萄球菌(S.saprophyticus)(1997年Crossley和Archer)。在本发明中金黄色葡萄球菌用作本发明作用方式的演示实施例。此外,因其对人类的严重病原性影响的它也是重要微生物。世界范围内,葡萄球菌感染在医院中成为日益严重的威胁。葡萄球菌的出现及致病能力与抗生素的广泛使用有关,后者引起和持续引起多重药物耐受性。因此葡萄球菌感染的医学治疗不能只依靠抗生素。因此,需要治疗策略转向预防感染。用疫苗诱导高度亲和的调理素型和中和型抗体可以帮助先天免疫系统清除细菌和毒素。这使得根据本发明的方法成为鉴定葡萄球菌抗原性蛋白的最佳工具。
每一个人都带有表皮葡萄球菌菌落。正常的表皮葡萄球菌聚集区是皮肤和粘膜。最具抗原性的金黄色葡萄球菌的主要聚集区是前面的鼻孔和会阴。一些个体成为金黄色葡萄球菌的永久携带者,通常是同一菌株。携带者的阶段就临床相性关,这是因为接受手术的携带者较非携带者更易产生感染。总的来说,鼻腔的已有细菌区系可以防止新菌株的入侵。但是当使用抗生素治疗清除易感性的携带者菌株时,其它的菌株就会趁机生长。这种情况通常发生在医院,患者会发生耐受医院环境的葡萄球菌的生长。这些微生物具有天生的适应能力,后者因广泛以及不当使用抗生素而得以加强。因此医院提供了一个药物耐受性增长的有利环境(重症病人的近距离接触,抗生素的过度使用,医院内的感染)。金黄色葡萄球菌和表皮葡萄球菌都可以耐受一些经常使用的抗生素,最严重的是耐新青霉素I(MRSA)和万古霉素(VISA)。药物耐受性是日益严重的公众健康问题,且很快许多葡萄球菌引起的感染将无法用抗生素治疗。除了对公众健康的不利作用,抗生素耐受也导致高额的医疗费用,因为治疗抗性感染通常要使用毒性更大,费用更高的药物,导致患者在医院滞留的时间更长。
尽管可以使用有效的抗生素,但最严重的葡萄球菌感染仍具有30-50%的死亡率。
当微生物与机体免疫系统的自然平衡被打乱时,也即机体的天然屏障(皮肤、粘膜)被突破时,葡萄球菌很快就成为非常有威胁的病原体。革兰氏阳性的金黄色葡萄球菌是最具病原性的葡萄球菌种类,长期以来都为外科医生所担心。最常见的是它引起手术伤口感染,从而导致脓肿。这种局部感染很快会遍及全身,引起菌血症和脓血症。尤其病毒感染后,在中老年人群中会引起严重的肺炎。金黄色葡萄球菌还是医疗器械相关感染的常见因素,例如血管内和经皮导管(内心膜炎,脓血症,腹膜炎),修复术仪器(败血性关节炎,骨髓炎)。表皮葡萄球菌引起的疾病通常与外来物体和使用的仪器有关,如导管相关的感染,脑脊髓液分路感染,透析患者的腹膜炎(主要是CAPD),修复心瓣膜患者的内心膜炎。同样的情况还发生在免疫妥协个体身上,如癌症患者和早产婴儿,在他们身上革兰氏阴性葡萄球菌感染的发生通常与血管内仪器的使用有关。这些疾病发病率的增加与这些治疗仪器使用的增加和免疫妥协患者人数的增加有关。
另一种革兰氏阴性葡萄球菌,腐生葡萄球菌的情况所知较少,其在以前健康的人群中引起尿道感染,大部分为年龄16-25岁的妇女。
葡萄球菌的发病机理是多因素的。为了引发感染,病原体必须接触宿主细胞和组织,即附着其上。金黄色葡萄球菌表达表面蛋白,其可促进其附着于宿主蛋白如层粘连蛋白,纤维结合素,弹性蛋白,玻璃粘连蛋白,纤维蛋白原和许多其它形成部分细胞外基质的分子(细胞外基质结合蛋白,ECMBP)。表皮葡萄球菌具有促进与外来物结合的细胞表面分子并通过这种机理引起宿主感染。葡萄球菌引发感染的另一个有效武器是其分泌产物,如肠毒素,外毒素和组织损伤酶。这些毒素可以杀死或蒙蔽对机体抵抗力起重要作用的免疫细胞。在感染过程中,这些不同类型的毒素引发了大多数症状。
宿主抵抗金黄色葡萄球菌主要依靠先天的免疫机制。皮肤和粘膜是强大的抗葡萄球菌入侵的屏障。但是,一旦皮肤和粘膜被突破(创伤或经皮导管等),非获得性的细胞防御的第一道防线开始通过补体,噬菌细胞,特别是多形核白细胞(PMNs)开始其协同作用。这些细胞被认为是清除入侵微生物的基础。由于葡萄球菌主要是细胞外病原体,因此主要的抗葡萄球菌的获得性反应来自免疫系统的体液防御,且由三种主要机制调节:促进调理作用,中和毒素,抑制附着。人们认为调理作用因其为有效的吞噬作用所要求而尤其重要。为进行有效调理,微生物表面必须被抗体和补体因子包被,以便通过对IgG分子的Fc片段或激活的C3b的受体而由PMNs识别。经调理后,葡萄球菌被噬菌细胞吞噬并杀死。此外,金黄色葡萄球菌可以附着在内皮细胞上,并经吞噬样过程内化。抗体结合于细菌细胞表面的特异性抗原,作为附着PMNs的配体并促进吞噬作用。相同的抗体结合外源凝集素及其它细胞表面蛋白,则中和外源凝集素并防止微生物生成菌落。
还没有临床证据表明细胞介导的免疫反应对机体抵抗葡萄球菌感染起重要作用,但是也不得不承认人们对这一问题所作的研究还不够。研究表明,金黄色葡萄球菌利用广泛的分子策略来应付感染宿主中的防御性微环境排列,通过分泌称为超级抗原的多肽,其以T细胞和抗原呈递细胞之间的多重受体交流为靶点,而抗原呈递细胞是启动抗原特异性免疫清除的基础。超抗原在中毒休克综合症和食物中毒中起重要作用,但它们在常规感染中的作用还不清楚。而且,无法想象长期持久的抗体反应没有T细胞参加。现在已知大多数抗葡萄球菌抗体抗不依赖T细胞的抗原(荚膜多糖,脂磷壁酸,肽聚糖)且没有记忆功能。依赖T细胞的蛋白类抗原能够引起长期的保护性的抗体反应。这些葡萄球菌蛋白和多肽还未确定。
由于上述原因,在抗葡萄球菌感染的斗争中急需改变策略。抗感染的一个方法是通过激活免疫反应来预防它们。世界范围内许多研究团体和国家研究所,正在开展抗金黄色葡萄球菌疫苗的研究,但是目前还无有效的疫苗产品得到通过。研究表明机体抗体缺乏状态有助于葡萄球菌的持续存在,这表明抗葡萄球菌抗体在宿主抵抗中起重要作用。无论是被动免疫附加产生,还是主动接种疫苗诱导产生,直接作用于抗原表面成分的抗体能够防止抗原附着,中和毒素,提高吞噬作用。基于纤维结合素结合蛋白的疫苗在牛身上激活抗乳腺炎的保护性免疫反应,这说明该方法可能也适用于人。总而言之,这说明有效的疫苗应由蛋白或多肽构成,其为所有菌株表达且能够诱导产生高亲和性,大量的抗金黄色葡萄球菌细胞表面成分的抗体。这些抗体应该是用于调理的IgG1或IgG3,和用于中和附着和毒素作用任何IgG亚型和IgA。化学限定的疫苗必须优于全细胞疫苗(减毒的或灭活的),因为瘫痪TH细胞的(超抗原)或阻断调理作用的(蛋白A)金黄色葡萄球菌成分可以被清除,并且可选择诱导保护性抗体的个体蛋白。相关抗原的鉴定有助于产生有效的被动免疫(人源单克隆抗体治疗),它可代替具有所有危险副作用的人免疫球蛋白给药。新生儿葡萄球菌感染,重症败血病和其它威胁生命的急性疾病是被动免疫的目标。有效的疫苗给一般面临外科手术和尤其是接受血管内仪器的患者提供很大可能的选择。而且,那些患有降低免疫反应的慢性疾病的患者和进行流动性腹膜透析的患者可能从这种疫苗获益。
在有关金黄色葡萄球菌的说明性实施例中,三组不同的方法平行使用。这三种方法都是依据本发明方法,基于人血清中的抗体与金黄色葡萄球菌蛋白或肽相互作用的原理。这种相互作用依赖对蛋白中的抗原确定簇的识别,其可为短肽(线性抗原决定簇)或多肽结构域(结构性抗原决定簇)。抗原性蛋白通过不同方法用预先选择的血清库鉴定,和或在第二轮筛选中用个体的所选血清鉴定。
经过高通量筛选,所选抗原蛋白表达为重组蛋白或体外翻译产物(如果其不能在原核表达系统表达),并用大量的人血清样品(未感染的血清样品大于100个,患者血清样品大于50个),通过一系列的ELISA和蛋白质印迹分析评估其免疫原性。优选的抗原位于细胞表面或为分泌型,即可细胞外接触。抗细胞壁蛋白的抗体(如胞外基质质结合蛋白)被认为有双重作用:阻止附着和促进吞噬作用。抗分泌型蛋白的抗体在毒素中和时有用。现在也已知细菌之间通过分泌型蛋白交换信息。抗这些蛋白的中和性抗体将打乱葡萄球菌不同种间或同种内的生长促进的相互交流。生物信息学(如信号序列,细胞壁定位信号,跨膜结构域)对评估细胞表面定位或分泌十分有用。实验方法包括用来自人血清的相应抗原决定簇和蛋白分离抗体,把它们作为试剂用于下列分析:对不同条件下生长的葡萄球菌进行细胞表面染色(FACS,显微镜方法),测定中和能力(毒素,附着),及对条理作用和吞噬作用的促进(体外吞噬作用分析)。
抗体对线性抗原决定簇的识别可基于短至4-5个氨基酸的序列。当然这并不意味短肽在体内能诱导抗体。由于这个原因,对特定的抗原决定簇,多肽和蛋白可进一步在动物中测试其体内诱导针对所选蛋白的抗体的能力(主要在大鼠中)。那些被证实能诱导抗体的抗原将在动物模型中检测其预防感染的能力。
人体免疫系统针对葡萄球菌产生的抗体或人血清中存在的抗体表明抗原性蛋白的体内表达及其免疫原性。
相应的,来自金黄色葡萄球菌或表皮葡萄球菌的超免疫血清反应性抗原可以通过根据本发明的方法制得。本发明的另一方面涉及超免疫血清反应性抗原,其选自表2a,2b,2c,2d,3,4和5任一所列的序列,尤其选自以下序列或其超免疫片段:Seq.ID No.56,57,59,60,67,70,72,73,74,75,76,77,78,79,80,81,82,85,87,88,89,90,92,95,96,97,99,100,101,102,103,104,106,108,110,112,114,116,118,120,122,126,128,132,134,138,140,142,151,152,154,155。相应的,本发明还涉及通过根据本发明的方法获得的和选自表2a,2b,2c,2d,3,4和5任一中所列序列的超免疫血清反应性抗原,特别选以下序列或其超免疫片段:Seq.ID No.56,57,59,60,67,70,72,73,74,75,76,77,78,79,80,81,82,85,87,88,89,90,92,95,96,97,99,100,101,102,103,104,106,108,110,112,114,116,118,120,122,126,128,132,134,138,140,142,151,152,154,155。
由根据本发明的方法提取的金黄色葡萄球菌和表皮葡萄球菌抗原可用于药物制剂的生产,尤其是生产抗金黄色葡萄球菌和表皮葡萄球菌感染的疫苗。那些可用于药物制剂的那些金黄色葡萄球菌和表皮葡萄球菌的超免疫血清反应性抗原的实例选自表2a,2b,2c,2d,3,4和5任一中所列序列,特别选自以下序列:Seq.ID No.55,56,57,58,59,60,62,66,67,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,87,88,89,90,92,94,95,96,97,99,100,101,102,103,104,106,108,110,112,114,116,118,120,122,126,128,130,132,134,138,140,142,151,152,154,155,158或其用于生产药物制剂的超免疫片段,尤其用于生产抗金黄色葡萄球菌和表皮葡萄球菌感染的疫苗。
超免疫片段定义为已鉴定抗原的片段,已鉴定抗原本身具有抗原性或以半抗原提供是可以被赋予抗原性。因此,本发明提供显示一或(对较长的片段)仅几个氨基酸改变的抗原或抗原片段,只要这种具有氨基酸改变的片段的抗原性并不因这种改变而严重降低,也就是说仍适合引起以此抗原接种的个体的免疫反应,并且被来自个体血清的个体抗体制备物所鉴定。
这种超免疫血清反应性抗原的超免疫片段的实例选自选自包含表2a,2b,2c,和2d的“预测的免疫原性氨基酸”、“鉴定的免疫原性区域的位置”、“同相关区域的血清反应性”栏中的氨基酸序列和表4,5的“推定的抗原性表面区域”栏中的氨基酸序列的肽,特别是包含下列氨基酸序列的肽,及其包含所述序列至少6个,优选大于8个,尤其大于10个氨基酸的片段,所有这些片段各自并且彼此独立地构成本发明优选的方面:
No.aa 12-29,34-40,63-71,101-110,114-122,130-138,140-195,197-209,215-229,239-253,255-274和39-94在Seq.IDNo.55,中
aa 5-39,111-117,125-132,134-141,167-191,196-202,214-232,236-241,244-249,292-297,319-328,336-341,365-380,385-391,407-416,420-429,435-441,452-461,477-488,491-498,518-532,545-556,569-576,581-587,595-602,604-609,617-640,643-651,702-715,723-731,786-793,805-811,826-839,874-889,37-49,63-77和274-334,在Seq.ID No.56,中
aa 28-55,82-100,105-111,125-131,137-143,1-49,在Seq.ID No.57,中
aa 33-43,45-51,57-63,65-72,80-96,99-110,123-129,161-171,173-179,185-191,193-200,208-224,227-246,252-258,294-308,321-329,344-352,691-707,358-411和588-606,在Seq.ID No.58,中aa 16-38,71-77,87-94,105-112,124-144,158-164,169-177,180-186,194-204,221-228,236-245,250-267,336-343,363-378,385-394,406-412,423-440,443-449,401-494,在Seq.ID No.59,中
aa 18-23,42-55,69-77,85-98,129-13 6,182-188,214-220,229-235,242-248,251-258,281-292,309-316,333-343,348-354,361-367,393-407,441-447,481-488,493-505,510-515,517-527,530-535,540-549,564-583,593-599,608-621,636-645,656-670,674-687,697-708,726-734,755-760,765-772,785-792,798-815,819-824,826-838,846-852,889-904,907-913,932-939,956-964,982-1000,1008-1015,1017-1024,1028-1034,1059-1065,1078-1084,1122-1129,1134-1143,1180-1186,1188-1194,1205-1215,1224-1230,1276-1283,1333-1339,1377-1382,1415-1421,1448-1459,1467-1472,1537-1545,1556-1566,1647-1654,1666-1675,1683-1689,1722-1737,1740-1754,1756-1762,1764-1773,1775-1783,1800-1809,1811-1819,1839-1851,1859-1866,1876-1882,1930-1939,1947-1954,1978-1985,1999-2007,2015-2029,2080-2086,2094-2100,2112-2118,2196-2205,2232-2243,198-258,646-727和2104-2206,在Seq.ID No.60,中
aa 10-29,46-56,63-74,83-105,107-114,138-145,170-184,186-193,216-221,242-248,277-289,303-311,346-360,379-389,422-428,446-453,459-469,479-489,496-501,83-156,在Seq.ID No.62,中
aa 14-22,32-40,52-58,61-77,81-93,111-117,124-138,151-190,193-214,224-244,253-277,287-295,307-324,326-332,348-355,357-362,384-394,397-434,437-460,489-496,503-510,516-522,528-539,541-547,552-558,563-573,589-595,602-624,626-632,651-667,673-689,694-706,712-739,756-790,403-462,在Seq.IDNo.66,中
aa 49-56,62-68,83-89,92-98,109-115,124-131,142-159,161-167,169-175,177-188,196-224,230-243,246-252,34-46,在Seq.ID No.67,中
aa 11-20,26-47,69-75,84-92,102-109,119-136,139-147,160-170,178-185,190-196,208-215,225-233,245-250,265-272,277-284,300-306,346-357,373-379,384-390,429-435,471-481,502-507,536-561,663-688,791-816,905-910,919-933,977-985,1001-1010,1052-1057,1070-1077,1082-1087,1094-1112,493-587,633-715 和704-760,在Seq.ID No.70,中
aa.6-20,53-63,83-90,135-146,195-208,244-259,263-314,319-327,337-349,353-362,365-374,380-390,397-405,407-415,208-287和286-314,在Seq.ID No.71,中
aa 10-26,31-43,46-58,61-66,69-79,85-92,100-115,120-126,128-135,149-155,167-173,178-187,189-196,202-222,225-231,233-240,245-251,257-263,271-292,314-322,325-334,339-345,59-74,在Seq.ID No.72,中
aa 4-9,15-26,65-76,108-115,119-128,144-153,38-52和66-114,在Seq.ID No.73,中
aa 5-22,42-50,74-81,139-145,167-178,220-230,246-253,255-264,137-237和250-267,在Seq.ID No.74,中
aa 10-26,31-44,60-66,99-104,146-153,163-169,197-205,216-223,226-238,241-258,271-280,295-315,346-351,371-385,396-407,440-446,452-457,460-466,492-510,537-543,546-551,565-582,590-595,635-650,672-678,686-701,705-712,714-721,725-731,762-768,800-805,672-727,在Seq.ID No.75,中
aa 5-32,35-48,55-76,在Seq.ID No.76,中
aa 7-35,54-59,247-261,263-272,302-320,330-339,368-374,382-411,126-143和168-186,在Seq.ID No.77,中
aa 5-24,88-94,102-113,132-143,163-173,216-224,254-269,273-278,305-313,321-327,334-341,31-61和58-74,在Seq.ID No.78,中
aa 16-24,32-39,43-49,64-71,93-99,126-141,144-156,210-218,226-233,265-273,276-284,158-220,在Seq.ID No.79,中
aa 49-72,76-83,95-105,135-146,148-164,183-205,57-128,在Seq.ID No.80,中
aa 6-15,22-32,58-73,82-88,97-109,120-131,134-140,151-163,179-185,219-230,242-255,271-277,288-293,305-319,345-356,368-381,397-406,408-420,427-437,448-454,473-482,498-505,529-535,550-563,573-580,582-590,600-605,618-627,677-685,718-725,729-735,744-759,773-784,789-794,820-837,902-908,916-921,929-935,949-955,1001-1008,1026-1032,1074-1083,1088-1094,1108-1117,1137-1142,1159-1177,1183-1194,1214-1220,1236-1252,1261-1269,1289-1294,1311-1329,1336-1341,1406-1413,1419-1432,1437-1457,1464-1503,1519-1525,1531-1537,1539-1557,1560-1567,1611-1618,1620-1629,1697-1704,1712-1719,1726-1736,1781-1786,1797-1817,1848-1854,1879-1890,1919-1925,1946-1953,1974-1979,5 to 134,在Seq.ID No.81,中
aa 6-33,40-46,51-59,61-77,84-104,112-118,124-187,194-248,252-296,308-325,327-361,367-393,396-437,452-479,484-520,535-545,558-574,582-614,627-633,656-663,671-678,698-704,713-722,725-742,744-755,770-784,786-800,816-822,827-837,483-511,在Seq.ID No.82,中
aa 4-19,57-70,79-88,126-132,144-159,161-167,180-198,200-212,233-240,248-255,276-286,298-304,309-323,332-346,357-366,374-391,394-406,450-456,466-473,479-487,498-505,507-519,521-530,532-540,555-565,571-581,600-611,619-625,634-642,650-656,658-665,676-682,690-699,724-733,740-771,774-784,791-797,808-815,821-828,832-838,876-881,893-906,922-929,938-943,948-953,969-976,1002-1008,1015-1035,1056-1069,1105-1116,1124-1135,1144-1151,1173-1181,1186-1191,1206-1215,1225-1230,1235-1242,6-66,65-124和590-604,在Seq.ID No.83,中
aa 5-32,66-72,87-98,104-112,116-124,128-137,162-168,174-183,248-254,261-266,289-303,312-331,174-249,在Seq.ID No.84,中
aa 4-21,28-40,45-52,59-71,92-107,123-137,159-174,190-202,220-229,232-241,282-296,302-308,312-331,21-118,在Seq.IDNo.85,中
aa 9-28,43-48,56-75,109-126,128-141,143-162,164-195,197-216,234-242,244-251,168-181,在Seq.ID No.87,中
aa 4-10,20-42,50-86,88-98,102-171,176-182,189-221,223-244,246-268,276-284,296-329,112-188,在Seq.ID No.88,中
aa 4-9,13-24,26-34,37-43,45-51,59-73,90-96,99-113,160-173,178-184,218-228,233-238,255-262,45-105,103-166和66-153,在Seq.ID No.89,中
aa 13-27,42-63,107-191,198-215,218-225,233-250,474-367,在Seq.ID No.90,中
aa 26-53,95-123,164-176,189-199,8-48,在Seq.ID No.92,中
aa 7-13,15-23,26-33,68-81,84-90,106-117,129-137,140-159,165-172,177-230,234-240,258-278,295-319,22-56,23-99,97-115,233-250和245-265,在Seq.ID No.94,中
aa 13-36,40-49,111-118,134-140,159-164,173-183,208-220,232-241,245-254,262-271,280-286,295-301,303-310,319-324,332-339,1-85,54-121和103-185,在Seq.ID No.95,中
aa 39-44,46-80,92-98,105-113,118-123,133-165,176-208,226-238,240-255,279-285,298-330,338-345,350-357,365-372,397-402,409-415,465-473,488-515,517-535,542-550,554-590,593-601,603-620,627-653,660-665,674-687,698-718,726-739,386-402,在Seq.ID No.96,中
aa 5-32,34-49,1-43,在Seq.ID No.97,中
aa 10-27,37-56,64-99,106-119,121-136,139-145,148-178,190-216,225-249,251-276,292-297,312-321,332-399,403-458,183-200,在Seq.ID No.99,中
aa 5-12,15-20,43-49,94-106,110-116,119-128,153-163,175-180,185-191,198-209,244-252,254-264,266-273,280-288,290-297,63-126,在Seq.ID No.100,中
aa 5-44,47-55,62-68,70-78,93-100,128-151,166-171,176-308,1-59,在Seq.ID No.101,中
aa 18-28,36-49,56-62,67-84,86-95,102-153,180-195,198-218,254-280,284-296,301-325,327-348,353-390,397-402,407-414,431-455,328-394,在Seq.ID No.102,中
aa 7-37,56-71,74-150,155-162,183-203,211-222,224-234,242-272,77-128,在Seq.ID No.103,中
aa 34-58,63-69,74-86,92-101,130-138,142-150,158-191,199-207,210-221,234-249,252-271,5-48,在Seq.ID No.104,中
aa 12-36,43-50,58-65,73-78,80-87,108-139,147-153,159-172,190-203,211-216,224-232,234-246,256-261,273-279,286-293,299-306,340-346,354-366,167-181,在Seq.ID No.106,中
aa 61-75,82-87,97-104,113-123,128-133,203-216,224-229,236-246,251-258,271-286,288-294,301-310,316-329,337-346,348-371,394-406,418-435,440-452在Seq.ID No.112,中
aa 30-37,44-55,83-91,101-118,121-128,136-149,175-183,185-193,206-212,222-229,235-242在Seq.ID No.114,中
aa 28-38,76-91,102-109,118-141,146-153,155-161,165-179,186-202,215-221,234-249,262-269,276-282,289-302,306-314,321-326,338-345,360-369,385-391在Seq.ID No.116,中
aa 9-33,56-62,75-84,99-105,122-127,163-180,186-192,206-228,233-240,254-262,275-283,289-296,322-330,348-355,416-424,426-438,441-452,484-491,522-528,541-549,563-569,578-584,624-641,527-544, 在Seq.ID No.142,中
aa 37-42,57-62,121-135,139-145,183-190,204-212,220-227,242-248,278-288,295-30,304-309,335-341,396-404,412-433,443-449,497-503,505-513,539-545,552-558,601-617,629-649,702-711,736-745,793-804,814-829,843-858,864-885,889-895,905-913,919-929,937-943,957-965,970-986,990-1030,1038-1049,1063-1072,1080-1091,1093-1116,1126-1136,1145-1157,1163-1171,1177-1183,1189-1196,1211-1218,1225-1235,1242-1256,1261-1269,624-684,在Seq.ID No.151,中
aa 8-23,31-38,42-49,61-77,83-90,99-108,110-119,140-147,149-155,159-171,180-185,189-209,228-234,245-262,264-275,280-302,304-330,343-360,391-409,432-437,454-463,467-474,478-485,515-528,532-539,553-567,569-581,586-592,605-612,627-635,639-656,671-682,700-714,731-747,754-770,775-791,797-834,838-848,872-891,927-933,935-942,948-968,976-986,1000-1007,1029-1037,630-700,在Seq.ID No.152,中
aa 17-25,27-55,84-90,95-101,115-121,55-101,在Seq.ID No.154,中
aa 13-28,40-46,69-75,86-92,114-120,126-137,155-172,182-193,199-206,213-221,232-238,243-253,270-276,284-290,22-100,在Seq.ID No.155中和
aa 7-19,46-57,85-91,110-117,125-133,140-149,156-163,198-204,236-251,269-275,283-290,318-323,347-363,9-42和158-174,在Seq.ID No.158,中
aa 7-14,21-30,34-50,52-63,65-72,77-84,109-124,129-152,158-163,175-190,193-216,219-234 在Seq.ID.No.168,中
aa 5-24,38-44,100-106,118-130,144-154,204-210,218-223,228-243,257-264,266-286,292-299在Seq.ID.No.174,中
aa 29-44,74-83,105-113,119-125,130-148,155-175,182-190,198-211,238-245在Seq.ID.No.176,中
尤其适合的辅助者(helper)抗原决定簇也源自这些抗原。特别优选的辅助者抗原决定簇选自表4,5中“推定的抗原表面区域”中所提到的肽,以及选自下列序列及其形成T细胞抗原决定簇的片段:Seq.ID No.56的氨基酸6-40,583-598,620-646及871-896,Seq.ID No.70的氨基酸24-53,Seq.ID No.74的氨基酸240-260,Seq.ID No.81的氨基酸1660-1682,和1746-1790,Seq.ID No.83的氨基酸1-29,680-709,和878-902,Seq.ID No.89的氨基酸96-136,Seq.ID No.94的氨基酸1-29,226-269,和275-326,Seq.IDNo.114的氨基酸23-47和107-156,和Seq.ID No.142的氨基酸24-53。
根据另一方面,本发明涉及包含如上鉴定的超免疫血清反应性抗原或其片段的疫苗,针对金黄色葡萄球菌和表皮葡萄球菌。这样的疫苗可包含一或多种针对金黄色葡萄球菌和表皮葡萄球菌抗原。可选,在复合疫苗中这种金黄色葡萄球菌或表皮葡萄球菌可以结合针对其他病原体的抗原。优选,这种疫苗进一步包含免疫刺激性物质,这些物质优选选自聚阳离子聚合物,特别是聚阳离子肽,免疫刺激性脱氧核苷酸(ODN),刺激神经组织的化合物,尤其是人生长激素,明矾,弗氏完全或不完全佐剂,或它们的组合物。这种疫苗还可以包含展示于遗传改造的微生物如大肠杆菌表面的表面展示蛋白平台上的抗原。
根据另一方面,本发明还涉及特异性的制备物,其包含的抗体抗金黄色葡萄球菌和表皮葡萄球菌抗原或如上限定的金黄色葡萄球菌和表皮葡萄球菌抗原片段。这些抗体优选为单克隆抗体。
生产这些多克隆或单克隆抗体制备物的方法为本领域技术人员熟知且记述于现有技术。生产这种单克隆抗体制备物的优选方法的特征为下列步骤:
-在非人类的动物内施用葡萄球菌抗原或或其如上定义的片段来引发免疫反应,
-摘取该动物的脾或脾细胞,
-制备这些脾细胞的杂交瘤,
-筛选和克隆特异于所述抗原的杂交瘤细胞,以及
-通过培养该克隆的杂交瘤细胞及可选进一步的分离步骤生产该抗体制备物。
优选,摘取脾或脾细胞涉及杀死所述动物。
单克隆抗体和片段可以被嵌合和人源化(1995年Graziano等)使得其可以被重复给药。或者人单克隆抗体及其片段可从噬菌体展示文库(McGuinnes等,1996)或从转基因动物获得(Bruggemann等,1996)。
生产针对本发明鉴定的所述金黄色葡萄球菌和表皮葡萄球菌抗原的多克隆抗体制备物的优选方法的特征为下列步骤:
-在非人类动物内通过施用葡萄球菌抗原或其片段来引发免疫反应,
-由动物取得含有抗体的体液,
-通过对所述含抗体体液进行进一步的分离步骤生产该抗体制备物。
这些单克隆或多克隆抗体制备物可用于生产治疗或预防葡萄球菌感染的药物。而且,它们也可以用作诊断和影相目的。
下面的实施例和附图进一步说明了这种方法,并不对其进行限制。
图1显示基于由ELISA测定的抗葡萄球菌抗体效价对血清的预先选择。
图2显示了在pMAL4.1中LSA50/6文库中DNA片段大小的分布。
图3显示了用生物素酰化的人血清进行的MACS选择。pMAL9.1中LSA50/6文库首先用10ug生物素酰化的人血清进行第一轮筛选(A),第二轮筛选(B)用1ug。P血清指患者血清,B血清指婴儿血清。在第2和3个次洗脱之后显示对每轮筛选选择的细胞数目。
图4显示是如在1∶5000稀释度用患者血清通过蛋白印迹所分析的,同由细菌表面展示分离的特异性克隆的血清反应性。
图5显示多肽与患者血清和具有用核糖体展示鉴定的抗原决定簇的健康个体血清的ELISA反应。
图6显示了用人血清检测的金黄色葡萄球菌表面蛋白的代表性2D免疫印迹。取生长于BHI培养基的金黄色葡萄球菌/COL的蛋白800ug,溶解于(PI值4-7)IEF和(9-16%)SDS-PAGE,然后转移至PVDF膜。封闭后,将膜同1∶20000的IC35血清孵育。通过抗人IgG/HRPO缀合和用ECL显影而显相血清IgG的结合。
图7说明了考马斯亮兰染色的金黄色葡萄球菌表面蛋白的代表性凝胶。金黄色葡萄球菌/COL的蛋白1mg溶解于(PI值4-7)IEF和(9-16%)SDS-PAGE。血清学蛋白质组分析后,选择来测序的点被标记。
图8A和8B显示了LPXTG细胞壁蛋白的结构。
图9说明了未感染和已感染患者中对LPXTGV的IgG反应,LPXTGV是新抗原且可能是金黄色葡萄球菌表面外源凝集素,由细菌表面展示文库和蛋白质组分析方法发现。
图10显示了用纯化的抗LPXTGV的IgG进行表面染色的金黄色葡萄球菌。
图11展示了用考马斯亮兰染色的金黄色葡萄球菌表面蛋白的代表性2D凝胶(左)。取来自琼脂培养至对数生长早期的金黄色葡萄球菌蛋白1mg,溶解于(PI值6-11)IEF和(9-16%)SDS-PAGE。标记血清学蛋白质组分析后选择来测序的点。相应的2D免疫印迹图(右)。取同一制备物中蛋白800ug平行溶解于2DE,然后转移至PVDF膜。封闭后,将膜同1∶10000的P-pool孵育。通过抗人IgG/HRPO缀合和ECL显影来显相血清IgG的结合。
实施例
发现新的金黄色葡萄球菌抗原
实施例1:由人血清制备抗体
人免疫系统产生的和存在于人血清中的抗葡萄球菌抗体说明抗原性蛋白的体内表达及其免疫原性。这些分子是本发明方法中鉴定个体抗原的关键,本发明基于特异性抗葡萄球菌抗体与金黄色葡萄球菌肽或蛋白的相互作用。为了解相关的抗体种类,人血清样本来自I,具有金黄色葡萄球菌急性感染的患者,如菌血症,脓血症,血管内和经皮的导管和仪器感染,伤口感染,表层和深度软组织感染。药物微生物学检验证明金黄色葡萄球菌是这些感染的诱发剂。II,本分析还包括来自未感染的成年人的血清样本,这是因为葡萄球菌感染很常见,通过皮肤和软组织感染(疥疮,伤口感染,牙周病等),机体与葡萄球菌相作用遭遇后的天然免疫反应就会导致抗体存在。
经过一系列ELISA分析,鉴定血清中关于金黄色葡萄球菌抗体的性质。多种葡萄球菌抗原被用来证实所测定的效价并不是相互交叉反应抗体的总结果。为此,不仅对金黄色葡萄球菌全细胞(蛋白A缺失的)提取物(生长于不同条件下)或全菌进行了ELISA分析,并且分析了由金黄色葡萄球菌中分离出的不同的细胞壁组分,如脂磷壁酸和肽聚糖。更重要的是建立重组蛋白样本代表已知的葡萄球菌细胞表面蛋白,来更好地鉴定现有人血清样本。
最近有文献报道,不仅IgG而且IgA血清抗体也可以被PMNs的FcRIII受体识别并增强调理作用(2000年Phillips-Quagliata等,2000年Shibuya等)。IgA抗体的主要作用是中和,主要于粘膜表面。血清IgA的水平反映了二聚体分泌型IgA的数量,质量和特异性。所以血清样本不仅进行抗葡萄球菌IgG的分析,还进行IgA水平的分析。在ELISA检验中,用高度特异性的二级试剂检测高度亲和型抗体,如IgG和IgA,并避免IgM。IgM抗体的产生发生在初级获得性体液反应阶段,并产生低亲和性抗体,而这时IgG和IgA抗体已经完成了亲和成熟期,并在治疗和预防疾病方面更有价值。
实验步骤
酶联免疫分析(ELISA)。ELISA平板用含有2-10ug/ml包被缓冲液(碳酸钠PH9.2)中的不同抗原包被。在TBS-BSA中制造100-100000的系列血清稀释。高度特异性(交叉吸收的)HRP(辣根过氧化物酶)标记的抗人IgG或抗人IgA二抗(Southern Biotech)根据说明书建议(~2.000x)使用。根据全自动ELISA仪(WallaceVictor 1420)OD405nm读数测定底物生成有色产物的量,来确定抗原抗体复合物的量。在给定稀释度下比较其效价,在这里稀释反应为线性(表1)。根据与多种葡萄球菌组分的反应性,对约100种血清进行了分级,选取最高的那些(90%以上)做进一步的抗原鉴定分析。重要的是,来自临床表现健康的人血清的抗葡萄球菌抗体相当稳定,在测定了3,6,9个月后显示出同样高的抗所有葡萄球菌抗原的ELISA效价(数据未提供)。相反地,抗金黄色葡萄球菌抗原的抗体在患者体内减少,甚至感染两周后消失(1998年Coloque-Navarro等)。然而来自患者的抗体是十分重要的,因为这是根据本发明的筛选中鉴定有免疫原性或在ELISA中测得的细菌抗原的体内表达的直接证据。
在鉴定抗体性质时,使用的这种综合方法是独一无二的,并导致对抗葡萄球菌超免疫血清的明确鉴定。
为基因组筛选而进行的抗体纯化。基于总体的抗葡萄球菌效价,选择了5个来自患者和非感染人群的血清样本。通过与大肠杆菌全细胞(DH5a,转化有pHIE11,在细菌显示条件下生长)孵育热失活血清,或用大肠杆菌溶菌液亲和层析来去除抗大肠杆菌蛋白的抗体来进行核糖体展示。根据制造商的说明通过蛋白G亲和层析(紫外联固定化的蛋白G,Pierce)从集合的,耗尽的血清制备IgG的高度富集的制备物。IgA抗体使用固定在链霉抗生物素琼脂糖(GIBCO BRL)的生物素标记的抗人IgA(Southern Biotech)通过亲和层析来纯化。耗尽率和纯化率通过SDS-PAGE,蛋白印迹,ELISA,蛋白浓度测试仪来检定。对于蛋白质组则不存在IgG和IgA的耗尽,因为二级试剂保证了特异性。
实施例2构建金黄色葡萄球菌的高度随机的,读框选择性的,小片段的基因组DNA库
实验步骤
葡萄球菌基因组DNA的制备。这一方法来自早先两个发表的流程(1998年Sohail,1984年Betley等),并且最早适用于二甲氧基苯青霉素抗性的金黄色葡萄球菌株COL来获得高质量大规模的基因组DNA。将来自冷冻管的菌种加入到含5ug/ml四环素的500mlBHI培养基中,37摄氏度通风摇床培养18小时。发酵液分为两份,每份250ml,1600xg离心15分钟,弃去上清。菌体沉淀用26ml 0.1mMPH7.6的Tris-HCl重悬,1600xg再次离心15分钟。沉淀用20ml1mM PH7.6的Tris-HCl,0.1mM的EDTA重悬,转移至50ml无菌的聚丙烯试管中。将10mg/ml热处理的RNA酶A 1ml和200U RNA酶T1加入每管并小心混合溶液。将250ul溶葡萄球菌酶(10mg/ml储液,在ddH2O中新鲜制备)加入到试管中,充分混合后于40摄氏度振荡水浴中培养10分钟。在加入1ml 10%的SDS后,40ul蛋白K(25mg/ml储液)和100ul 10mg/ml的链霉蛋白酶后,将试管颠倒震摇数次,于40摄氏度摇动水浴培养5分钟。向试管中加入3.75ml5M NaCl和2.5ml十六烷基三甲基溴化铵(CTAB)溶液(10%w/v,4%w/v NaCl),进一步在65摄氏度摇动水浴中培养10分钟。样品冷却至室温后,用PhOH/CHCl3/IAA(25∶24∶1)和CHCl3/IAA(24∶1)抽提。小心收集水相并转移至新的50ml无菌试管中。向每个试管中加入1.5ml StratacleanTM树脂后,慢慢地充分混匀,并在室温下孵育1分钟。样品离心后,收集含有DNA的上层移至50ml干净试管中。室温下加入0.6倍体积的异丙醇使DNA沉淀,用无菌塑料吸液管将DNA缠绕出,并转移至装有80%冰冷乙醇的试管中。10-12000xg离心沉淀物,回收DNA。接着空气中干燥,并重新溶解于ddH2O。
小的基因组DNA片段的制备。使用cup-horn超声波仪通过机械作用将基因组DNA片段剪成150-300bp的小片段(Bandelin SonoplusUV 2200,带有BB5 cup horn的超声波仪,10秒钟脉冲,100%输出功率),或者用温和性的DNA酶I处理,切割成50-70bp的小片段。据观察当超声波将DNA切断成150-300bp大小的片段时,会产生很紧凑的片段大小分布。然而,即使将DNA充分暴露于超声波诱导的流体剪切力剪切,也不会有效并可重复地实现后续片段大小的降低。因此使用Novogen的鸟枪试剂盒,用温和性DNA酶I处理可以得到50-70bp大小的片段。首先制备试剂盒中DNA酶I的1∶20的稀释液,在60ul体积,在MnCl2的存在下,20摄氏度消化作用5分钟,保证双链酶切。加入2ul 0.5M EDTA终止反应,用2%TAD-琼脂糖凝胶来观察碎片生成情况。这种处理可以使基因组DNA全部片段化为50-70bp的碎片。碎片接着用T4 DNA聚合酶,在100uM dNTP存在下平末端化两次,保证末端有效平齐。碎片马上用于连接反应,或者-20摄氏度冻存备用。
载体的描述。载体pMAL4.1在pEH1骨架基础上构建(1998年Hashemzadeh-Bonehi等),带有卡那霉素抗性基因。另外它还包含一个克隆至多克隆位点的b-内酰胺酶(bla)。该bla基因之前为ompA的前导肽序列,以保证其能有效地穿过细胞膜而分泌。SmaI限制性酶切位点作为文库的插入点。SmaI两侧,上游为FseI位点,下游为NotI位点用于回收所选片段。在ompA前导序列之后插入三个限制性位点,使得bla基因在-1阅读区被转录,而在NotI位点后15bp处产生一个终止子。+1bp插入恢复bla开放性阅读框架,这样b-内酰胺酶蛋白可以产生,由此获得胺苄青霉素抗性。
载体pMAL4.31在pASK-IBA基础上构建(1994年Skerra等),其卡那霉素抗性基因代替了b-内酰胺酶基因。另外它还包括一个被克隆至多克隆位点的b-内酰胺酶基因。在编码成熟b-内酰胺酶的基因之前加入ompA的前导肽序列,以保证其能有效的穿过细胞膜而分泌。OmpA前导肽之后有编码成熟b-内酰胺酶的起始12个氨基酸的序列,来避免在前导肽酶切位点后面序列立即融合,因为这一区域阳性氨基酸基因簇会降低或破坏穿越细胞膜的易位(2000年Kajava等)。SmaI限制性位点用作文库的插入点。SmaI两侧,上游为FseI位点,下游为NotI位点用于恢复所选片段。编码成熟b-内酰胺酶的起始12个氨基酸的序列之后插入三个限制性位点,使得bla基因在-1阅读区被转录,而在NotI位点后15bp处产生一个终止子。+1bp插入恢复bla开放性阅读框架,这样b-内酰胺酶蛋白可以产生,并由此获得胺苄青霉素抗性。
载体pMAL9.1通过将lamB基因克隆至pEH1的多克隆位点而建立。然后,在lamB基因第154氨基酸后插入含有Fsa1,SmaI,NotI限制位点的序列。选择这一插入区域的阅读框架,使得用FseI和NotI从质粒pMAL4.1或pMAL4.31消化切出的读框选择的DNA片段转移到pMAL9.1会产生lamB的连续阅读框架和相应的插入。
载体pHIE11通过将fhuA基因克隆至pEH1的多克隆位点而建立。此后,在fhuA基因第405氨基酸后加入含有FsaI,SmaI,NotI限制位点的序列。选择这一插入区域的阅读框架,使得用FseI和NotI从质粒pMAL4.1或pMAL4.31消化切出的读框选择的DNA片段转移到pHIE11会产生fhuA的连续阅读框架和相应的插入位点。
克隆和评价文库的读框选择。金黄色葡萄球菌基因组DNA片段连接至载体pMAL4.1或pMAL4.31的SmaI位点。重组DNA用电穿孔的方法导入DH10B电感受态的大肠杆菌细胞(GIBCO BRL),将转化子涂至补充有50ug/ml卡那霉素和50ug/ml胺苄青霉素的LB-琼脂培养基。平皿37摄氏度培养过夜,挑取菌落进行大规模DNA提取。保存一个有代表性的平皿,以备筛选菌落用作菌落PCR分析和大规模测序。用简单菌落PCR分析来最初确定大致的片段大小分布以及插入效率。由测序数据来精确评价片段大小,插入位点的连接完整性以及读框选择的准确性(3n+1规则)。
菌体表面展示文库的克隆和评价。用限制性内切酶FseI和NotI由含有金黄色葡萄球菌文库的pMAL4.1或pMAL4.31载体上切出基因组DNA片段。将完整的片段群体转移至经过FseI和NotI消化的质粒pMAL9.1(LamB)和pHIE11(FhuA)。使用这两种识别8bpGC富集序列的限制性内切酶,在Pmal4.1或Pmal4.31载体中选择的阅读框架在每个平台载体中都被保留下来。质粒文库通过电转导的方法转移至大肠杆菌DH5a细胞。细胞涂于含有50ug/ml卡那霉素的LB-琼脂平皿,37摄氏度培养过夜,来产生清晰可见的单菌落。将平皿表面的细胞刮下,用新鲜LB培养基洗涤后-80摄氏度冻存用于文库筛选。
结果
用于读框选择的文库。在pMAL4.1载体分别以大小约50和250bp产生两个库(LSA50/6和LSA250/1)。对于每个库,读框选择后克隆总数1-2×106达到,用大约1ug pMAL4.1质粒DNA和50ng片段化的金黄色葡萄球菌基因组DNA。为了评价LSA50/6库的随机性,随机选择了672个克隆进行测序。生物学信息分析表明这些克隆间并没有重复。并且90%的克隆大小在19-70bp之间,平均大小为25bp(图2)。所有的672个序列都遵守3n+1规则,这表明所有的克隆都是合适的所选框架。
菌体表面展示文库。在大肠杆菌表面展示肽需要将来自框架选择载体pMAL4.1的LSA50/6库的插入片段向展示质粒pMAL9.1(LamB)和pHIE11(FhuA)转移。基因组DNA片段用FseI和NotI限制性酶切出,连接0.1ug质粒DNA和5ng插入片段,产生了2-5×106个克隆。将菌落由平皿上刮下,冻存而不做进一步的放大。
实施例3,使用菌体表面展示的基因库和人血清鉴定来自金黄色葡萄球菌的高度免疫原性多肽序列
实验步骤
MACS筛选。来自给定文库的约2.5×108个细胞在含有50ug/ml卡那霉素的5ml LB培养基中,37℃培养2小时。加入1mMIPTG放置30分钟来诱导表达。细胞用新鲜的LB培养基洗涤两次,大约有2×107个细胞重悬浮在100ulLB培养基中,然后转移至Eppendorf管。
将10ug生物素酰化的人血清加入到细胞中,4℃轻微震摇培养过夜。再加入900ul LB培养基,混匀后4℃,6000rpm离心10分钟。细胞用1ml LB洗涤,接着重悬于100ul LB培养基。加入10ul偶联链霉抗生物素的MACS微球(德国Miltenyi Biotech公司),4℃培养20分钟。再加入900ul LB培养基,将MACS微球细胞悬浮液上样到固定于磁铁的MS柱(德国Miltenyi Biotech公司)。MS树脂柱用1ml 70%乙醇洗涤一次,再用2mlLB培养基洗涤两次来进行平衡。
接下来用3ml LB培养基洗涤柱3次。以去掉磁铁并用2ml LB培养基洗涤来进行洗脱。3ml LB培养基洗涤树脂柱后,将2ml洗脱液再次上同一柱,并且重复洗涤和洗脱过程。上柱,洗涤,洗脱过程重复3次,最终得到2ml洗脱液。
第二轮筛选操作如下。离心最终的洗脱液,收集细胞并重悬于含有50ug/ml卡那霉素的1ml LB培养基中。培养液37℃培养90分钟,加入1mM IPTG诱导30分钟。收集细胞,用1ml LB培养基洗涤一次后,悬浮于10ul LB培养基。由于体积减少,加入1ug生物素酰化的人血清后,悬浮液在4℃轻微震摇孵育过夜。所有进一步的步骤与第一轮筛选完全相同。收集两个筛选后的细胞,涂于含有50ug卡那霉素的LB琼脂平皿,37℃培养过夜。
通过测序和蛋白印迹来评价选定的克隆。将选定的克隆在含有50ug/ml卡那霉素的3ml LB培养基中培养过夜,按照标准程序来制备质粒DNA。在德国的MWG公司或同TIGR合作(美国的)进行的测序。
蛋白印迹分析表明,大约10-20ug的总细胞蛋白通过10%SDS-PAGE凝胶分离,并且印到HybondC膜(英国Amersham PharmaciaBiotech公司)。LamB或FhuA融合蛋白用稀释度为1∶5000的人血清作为一级抗体和稀释度为1∶5000偶联至HRP的抗人IgG抗体作为二级抗体来检测。检测使用英国Amersham Pharmacia Biotech公司的ECL检测试剂盒。或者,兔抗FhuA和鼠抗LamB抗体用作一级抗体,结合偶联至HRP的相应的二级抗体结合来检测融合蛋白。
结果
通过使用生物素酰化的人血清的磁性活化细胞分类(MACS)筛选菌体表面展示文库。pMAL9.1中的LSA50/6库和pHIE11中的LSA250/1库用生物素酰化的人类患者血清库筛选(见实施例1,从人血清制备抗体)。选择程序按下列实验步骤描述如下进行。来自未被金黄色葡萄球菌感染的婴儿血清库作为对照。在已介绍的条件下,常规选择比婴儿血清多10-50倍的患者血清(图3)。为了评价筛选性能,随机挑取了大约100个克隆,与相同的患者血清库进行了蛋白印迹。分析结果表明30-50%选定的克隆与患者血清中的抗体呈现反应,而表达LamB或FhuA却不含金黄色葡萄球菌特异性插入片段的对照菌株则不与同一血清发生反应。菌落PCR分析表明,所选克隆都包含一个在预期大小范围内的插入片段。
随后测序大量的随机挑取的菌落(每次筛选500-800个),来鉴定由筛选所用的患者血清特异性识别的基因以及相应的多肽或蛋白序列。特异性克隆被选定的频率至少部分地反应了所用血清中特异性抗体选择和识别这一克隆中存在的抗原决定簇的冗余度和/或亲和力。在这方面,令人震惊的是一些克隆(ORF2264,ORF1951,ORF0222,脂肪酶和IsaA)被挑取了90次,说明它们具有高度的免疫原性。表2中的所有克隆由使用来自单克隆的全细胞提取物的蛋白印迹验证了其显示所指的与筛选所用人血清库的反应能力。
值得进一步注意的是菌体表面展示筛选所鉴定的基因编码的蛋白,或者附着在金黄色葡萄球菌表面,或者分泌至胞外。这与金黄色葡萄球菌表面附着或分泌蛋白被预期的在其毒性中的作用相一致。
用不同的人血清评定高免疫原性肽序列的反应性。使用10-30种不同的患者血清,来评价抗所选的根据本发明筛选发现的免疫原性肽序列的抗体的存在。为了消除与大肠杆菌表达蛋白可能出现的交叉反应,所有的血清都用表达FhuA蛋白的大肠杆菌Dha细胞全细胞溶菌液预吸收。
这一分析总结在表2中,另外在图4出示了实例,并说明了本筛选的可行性。其进一步说明短的已经选定的表面决定簇在大量患者中都可以引起抗体的产生(ORF1618,ORF1632,IsaA,Empbp,蛋白A)。那些不被较大组的患者血清识别的肽序列可仍为部分超免疫原性蛋白,但重组蛋白本身为了这一目可进行单独情况的检验。
实施例4使用核糖体展示和人血清,鉴定来自金黄色葡萄球菌基因组片段的超免疫原性肽序列。
实验步骤
核糖体展示筛选:来自pMAL4.1中的金黄色葡萄球菌LSA250/1的2.4ng基因库用寡聚ICC277和ICC202扩增,以便用于核糖体展示。寡聚ICC277(CGAATAATACGACTCACTATAGGGAGACCACAACGGTTTCCCACTAGTAATAATTTTGTTTAACTTTAAGAAGGAGATATATCCATGCAGACCTTGGCCGGCCTCCC)和ICC202(GGCCCACCCGTGAAGGTGAGCCGGCGTAAGATGCTTTTCTGTGACTGG)分别同pMAL4.1质粒的FseI-NotI插入位点的5’和3’杂交。ICC277引入一个T7噬菌体RNA聚合酶启动子,一个回文结构可以导致RNA水平的茎环结构,一个核糖体结合位点(RBS)和包括ATG起始密码子的T7噬菌体基因10的翻译起始点。寡聚ICC202在β-内酰胺酶开放阅读框架的核苷酸位点668处杂交,且也在所得RNA的3末端引入茎环结构。PCR用高保真PCR试剂盒(RocheDiagnostic公司)进行,50℃杂交温度,25个循环,其它则为标准条件。
产生的PCR文库由核糖体展示用于五轮连续的选择和放大步骤,核糖体展示与前述相似(1997年Hanes等),但是修正如下。
一轮核糖体展示包括下列步骤:使用RiboMax试剂盒(Promega公司)体外转录2ugPCR产物,产生ca.50ugA。体外翻译在37℃22ul体积下,使用4.4ul Premix Z(250mM Tris-醋酸PH7.5,1.75mM各种氨基酸,10mM ATP,2.5mM GTP,5mM cAMP,150mM乙酰磷酸,2.5mg/ml大肠杆菌tRNA,0.1mg/ml亚叶酸,7.5% PEG8000,200mM谷氨酸钾,13.8mM醋酸镁,8ul S30提取物(xmg/ml)和2ug来自库集的体外转录的RNA)反应9分钟。S30提取物由已报道文献制备(1983年Chen等)。下一步,样品转移至冰冷的试管,其中含有35.2ul 10%的milk-WBT(Tris-醋酸PH7.5,150mM NaCl,50mM醋酸镁,0.1%土温-20,10%奶粉)和52.8ul WBTH(如从前,加入2.5mg/ml肝素)。接着进行免疫沉淀,加入10ug纯化的IgGs,冰浴孵化90分钟,然后加入30ul MAGmol蛋白G小珠(MiltenyiBiotech公司,冰浴处理90分钟)。样品加入到预先平衡的μ柱(Miltenyi Biotech公司),用冰冷的WBT缓冲液冲洗5次。然后将EB20洗脱缓冲液(50mM Tris-醋酸,150mM NaCl,20mM EDTA,50ug/ml啤酒糖酵母RNA)上柱,4℃孵育5分钟。加入EB202×50ul完成洗脱。洗脱液中的mRNA用高纯度RNA分离试剂盒(Roche Diagnostic公司)纯化。随后的反转录使用Superscript II反转录酶试剂盒(Roche Diagnostic公司),按照制造商的说明进行操作,60pmol寡聚ICC202,50ul体积50℃下反应1小时。5ul混合物与前文所述的ICC202和ICC277引物用于随后的PCR反应。
核糖体展示进行3个循环,将结果选定的PCR克隆至用限制性内切酶NotI和Fsa1切割的质粒pHIE11中。
通过测序和肽-ELISA分析对选定的克隆进行评估:选定的克隆在含有50ug/ml卡那霉素的3ml LB培养基中37℃培养过夜,按照标准程序来制备质粒DNA。测序工作在德国MWG公司和基因组研究所(TIGR;Rockville,MD,美国)进行。合成出相对于插入片段的肽并在10mM NaHCO3中pH9.3条件下,以10ug/ml(50ul)浓度在96孔微量板(Nunc)中包装。在37℃用PBS中的1%BSA封闭后,将所指血清以1∶200和1∶1000的稀释度在1%BSA/PBS中稀释,并加入到孔中。用PBS/0.1%土温-20洗涤后,加入生物素标记的抗人IgG二抗(SBA),按照标准程序,由随后加入的偶联链霉抗生物素的辣根过氧化物酶进行检测。
结果
用前文所述的250bp基因组文库(LSA250/1)进行筛选。来自前文所述未被感染但是对金黄色葡萄球菌具有较高效价的成年人的纯化IgGs选择抗原性肽。
根据实验程序进行了3轮核糖体展示的选择和放大;并最后对产生的PCR库集进行了克隆和测序。
对大量随机挑取的菌落的序列分析(700个)使得能够鉴定被筛选所用的高效价血清特异性识别的基因以及相应的肽和蛋白序列。特异性克隆的被选频率至少部分地反应了筛选血清中特异性抗体选择和识别这一克隆的冗余度和/或亲和力。令人注意的是一些克隆(ORFs)被挑取了50次,这说明它们具有高度的免疫原性。表2显示了ORF的名称,Seq.ID号和在筛选时被鉴定的次数。
合成与已鉴定的免疫区域相对应的一些免疫选择的ORF肽,在多肽-ELISA中检测其对鉴定它们所用的血清库的反应性,这些血清还包括一些来自金黄色葡萄球菌感染的患者的血清。图5的两个举例显示了来自金葡菌溶菌酶和Pls的肽的价值。它们不仅对高效价血清库而且还对许多个别患者的血清都具有超免疫反应性。所有相应于选定的免疫原区域的合成肽对高效价血清库都显示了反应活性,表2总结了这些多肽与不同患者血清反应的次数,与前文所述相似。
实施例5,用血清学蛋白质组分析鉴定来自金黄色葡萄球菌的高免疫原性抗原
实验步骤
来自金黄色葡萄球菌的表面蛋白制备物包含高免疫原性抗原。金黄色葡萄球菌COL菌株(1979年Shafer和Iandolo)和agr-菌株(1986年Recsei等)在甘油中于-80℃或在BHI(DIFCO)平皿上4℃保存。在BHI(“标准条件”)或RPMI1640(GibcoBRL)中单菌落接种过夜培养,后者用亚胺基二乙酸(Sigma)处理去掉铁离子(“逆境条件”)。第二天按1∶100比例倒入新鲜培养基,菌体生长至OD600值介于0.3-0.7之间。离心收集菌体,用冰冷的PBS洗涤。表面蛋白用容葡萄球菌酶处理,在等渗条件下制备(Lim等1998年)。简单的说,~3×109个菌体(根据OD600=1时,菌体数为5×107)重悬于含有35%绵子糖(Aldrich化学公司),蛋白酶抑制剂(Roche公司)和5单位溶葡萄球菌酶(Sigma公司)的消化缓冲液中。37℃培养30分钟后,原生质体用低速离心小心地使其沉淀。这种处理可以将与肽聚糖细胞壁的5甘氨酸桥共价相连的表面蛋白释放至上清液中(1997年在Crossley)。细胞表面蛋白或者用甲醇或氯仿沉淀(1984年Wessel)或在离心过滤试管(Millipore)中浓缩。蛋白样品冷冻并于-80℃保存,或溶解于样品缓冲液,并立刻用于等电聚焦(IEF)(1997年Pasquali等)。
血清学蛋白质组分析来自金黄色葡萄球菌的表面蛋白制备物。样品来自a),在逆境条件下生长的金黄色葡萄球菌/agr菌株;b),标准条件下生长的金黄色葡萄球菌/COL菌株;和c),逆境条件下生长的金黄色葡萄球菌/COL菌株。使用“in-gel-reswellingprocedure”将表面蛋白上样到含有固定化的PH梯度(PH4-7,BioRad)的17厘米条带上。将带有100-800ug蛋白的凝胶上样,而制备级凝胶具有400-1000ug蛋白。按照文献记载进行等电聚焦和16%交连度的SDS-PAGE(1997年Pasquali等)。为了进行蛋白印迹,将蛋白通过半干燥印染转移至PVDF膜(BioRad公司)。转移效率用氨基染色法检查。(用PBS/0.1%土温20/10%干牛奶,4℃ 16小时)封闭后,胶条与(1∶2500-1∶10000封闭溶液中,见表3)血清孵育两小时。洗涤后,血清IgG的特异性结合用羊抗人IgG/过氧化物酶缀合物作为二级抗体(1∶25000,Southern Biotech)并用化学发光物显影(ECLTM,Amersham)而显像。图6显示了一个有代表性的结果。膜用2% β-ME/Laemmli缓冲液在50-65℃处理30分钟,然后立刻用不同的血清重探测,并依据前文所述方法显影。这一过程重复5次。同患者或健康捐献者对照血清显示信号,而对婴儿血清库则不显示的信号,与考马斯(BioRad)染的制备凝胶情况相匹配(图7示实例)。这些来自金黄色葡萄球菌的表面蛋白制备物的血清学蛋白质组分析总结在表3中。
使用肽-指纹MALDI-TOF-MS和前后MS/MS测序蛋白点。凝胶块用10ul消化缓冲液(10mM NH4HCO3/CAN,1∶1)另外洗涤3次。接着凝胶块用10ul ACN缩小,再用2ul蛋白酶溶液(0.05ug/ul胰蛋白酶,Promega,Madison,美国)使其重新膨胀。37℃消化10-12小时。对于MALDI-TOF-MS,用10ul消化缓冲液将凝胶块中的肽提取出。上清用ZipTipTM(Millipore,Bedford,美国)浓缩。用0.5ul提取缓冲液(0.1% TFA/CAN,1∶1)将肽洗脱至MALDI的靶点,然后加入0.5ul基质溶液(ACN/0.1% TFA中HCCA,1∶1)。MALDI-TOF-MS使用带有SCOUT384离子源的REFLEX III(Bruker Daltonik,Bremen,德国)进行。加速电压设为25KV,反应电压为28.7KV。质量范围700-4000Da。使用XACQ软件(4.0版本)在SUN Ultra上得到数据。分析后数据处理使用XMASS软件(4.02版本)处理(Bruker Daltonik,Bremen,德国)。结果总结在表3和表4中。
实施例6,来自金黄色葡萄球菌的高免疫原性蛋白的性质鉴定
使用来自预先选择的血清的IgG和IgA通过不同的筛选方法鉴定的抗原进一步进行性质鉴定,具体方法如下:
1.纯化蛋白,其优选为在大肠杆菌或在革兰氏阳性表达系统或体外翻译系统表达的重组蛋白,并通过一系列人血清来评估其抗原性。根据生物学信息分析对蛋白结构进行了修饰:去除代表信号肽的N末端序列,去除细胞壁锚定位点的下游C末端区域,引进作为标签的多余氨基酸来简化纯化(如Strep-tagII,His-tag等)。大量血清在ELISA分析中被使用,来评估包含抗给定蛋白的特异性抗体的人血清级分(见图9举例)。一个选定的抗原是一段895个氨基酸长度的蛋白,叫做LPXTGV(见表2和4),由于其包含革兰氏阳性细胞壁锚定位点序列LPXTGV。这一信号被显示作为分类酶的酶切位点,后者是转运蛋白酶,共价连接含LPXTG区的蛋白到肽聚糖细胞壁(图8)。使用为Strep-tag重组蛋白的这一蛋白的ELISA数据表明,这一蛋白对大部分血清具有高度的免疫原性(与其它重组蛋白相比具有高的效价)(图9)。重要的是,急性金黄色葡萄球菌感染的患者与正常人相比产生更多这种抗LPXTGV的抗体,这表明这种蛋白在体内感染时表达。比较了不同抗原性蛋白的综合ELISA效价,那些在多数不同个体中(体内各种菌株表达的蛋白)都能够诱导产生最高抗体水平(高免疫原性)的蛋白是较好的。由于不同患者对金黄色葡萄球菌产生的抗体的抗原特异性和质量(族,亚型,功能的,非功能的)可能不同,由于感染的部位,并伴随慢性疾病(如糖尿病),慢性状况(如血管内的仪器)和不同个体的免疫反应,特别关注不同患者群体中检测出的差别,因为可以得到每个血清的医疗记录。另外,每个患者血清都在血清取样时带有自患者所分离的病原性菌株。
2.纯化特异性抗体进行功能鉴定。重组蛋白的纯度和完整性被检测(如在蛋白印迹分析中对比SDS-PAGE中的银染,检测其N末端Strep-tag)。通过tag固定抗原来产生亲和基质,并用于从高反应性血情中纯化特异性抗体。将实例中Strep-标记的LPXTGV作为捕获抗原,由125mg IgG中纯化得到20ug抗体。根据ELISA数据,得到更纯的制备物,且没有抗LTA和抗肽聚糖活性(两者都与未分级的IgG呈显性)。然后抗体用于通过FACS和荧光显微镜来检测细胞表面定位(图10)。
3.临床分离物中的基因发生率。
一个理想的疫苗应该是抗原,它存在于该疫苗所针对的目标生物体的所有或绝大多数菌株中。为了确认是否编码已鉴定金黄色葡萄球菌抗原的基因在金黄色葡萄球菌菌株中普遍存在,对一系列独立的金黄色葡萄球菌分离物用特异于目的基因的引物进行了PCR。金黄色葡萄球菌分离物由具有不同金黄色葡萄球菌感染的患者得到。另外一些来自健康携带者鼻腔的分离物和一些实验室菌株也被采集和分析。菌株根据对spa和coa基因的限制性片段长度的多态性(RFLP)确定其分类(1992年Goh等,1994年Frenay等,1999年vanden Bergh等)。从这些结果中鉴定出30种不同的菌株,24个患者分离物,3个鼻腔分离物,3个实验室菌株。为了确定所选抗原的基因分布,用选定表面决定簇(ORF1361:Seq.ID No.18 和188;ORF2268:Seq.ID No.193和194;ORF1951:Seq.ID No.195和196;ORF1632:Seq.ID No.181和182;ORF0766:Seq.ID No.183和184;ORF0576:Seq.ID No.185和186;ORF0222:Seq.ID No.189和190;ORF0360:Seq.ID No.191和192)两侧的基因特异性引物,对这30个菌株的基因组DNA进行了PCR。通过凝胶电泳分析来确定具有预期大小的PCR产物。ORFs1361,2268,1951,1632,0766和0222存在于所有被测菌株中且ORF0576存在于97%的菌株中。然而ORF0360则只出现在71%的菌株中。这样ORF1361,2268,1951,1632,0766和0222各自在金黄色葡萄球菌分离物中普遍存在。
这些抗原(或其抗原性片段,特别是已鉴定的片段)尤其优选用于抗金黄色葡萄球菌疫苗的计划。
4.用所选抗原的ORF对高度杂交的人白细胞II类辅助表面抗原决定簇进行鉴定。
与基于被人血清中抗体识别而鉴定的抗原相应的ORFs中,大多可能含有线性T细胞表面决定簇。在本发明过程中令人惊奇地发现,即使健康未感染、非菌群生长的个体也显示出极高的抗体效价(对于某些抗原>100000,见实施例5),且稳定期>一年(见实施例1),这表明T细胞依赖的记忆的存在很可能由CD4+辅助T细胞介导。相应的人白细胞II类辅助表面抗原决定簇的分子定义可用于设计合成的能够诱导免疫记忆效应的抗金黄色葡萄球菌的疫苗。这里,由葡萄球菌抗原衍生的辅助表面抗原决定簇,为抗这些抗原或其片段的B细胞反应,提供了“同类帮助”。甚至有可能使用这些辅助表面抗原决定簇来诱导对非T细胞依赖抗原的记忆,例如碳水化合物(结合(conjugate)疫苗)。另一方面,细胞内出现的葡萄球菌可以被CD8+细胞毒T细胞清除,它可以识别人白细胞I型限制的表面抗原决定簇。
T细胞表面抗原决定簇可以由多种公共领域的算法库预测:http://bimas.dcrt.nih.gov/molbio/hla bind/(Parker等,1994);http://134.2.96.221/scripts/MHCServer.dll/home.htm(Rammensee等,1999);http://mypage.ihost.com/usinet/hamme76/(Sturniolo等,1999)。后一种预测算法提供了鉴定杂交辅助表面抗原决定簇,即结合多种人白细胞II型分子的肽的可能性。为了在葡萄球菌抗原中鉴定高度杂交的辅助表面抗原决定簇,使用TEPITOPE包http://mypage.ihost.com/usinet.hamme76/(1999年Sturniolo等),分析了对应下列序列的ORF:Seq ID 64(IsaA),Seq ID114(POV2),Seq ID 89(ORF0222),Seq ID 70(LPXTGIV),SeqID 56(LPXTGV),Seq ID 142(LPXTGVI),Seq ID 81(ORF3200),Seq ID 74(ORF1951),Seq ID 94(Empbp),Seq ID 83(自溶素)和Seq ID 58(ORF2498)。分析了25个普遍的DR-等位基因,选出了那些符合预期条件的肽,条件是a对至少10/25个等位基因有较强的结合能力(1%临界值);b与至少17/25个等位基因有中等结合能力(3%临界值)。
选出下列包含一或多个杂交辅助表面抗原决定簇的肽(且要求保护):
Seq ID 56:pos.6-40,583-598,620-646,871-896
Seq ID 58:没有符合选择标准的肽
Seq ID 64:没有符合选择标准的肽
Seq ID 70:pos.24-53
Seq ID 74:pos.240-260
Seq ID 81:pos.1660-1682,1746-1790
Seq ID 83:pos.1-29,680-709,878-902
Seq ID 89:pos.96-136
Seq ID 94:pos.1-29,226-269,275-326
Seq ID 114:pos.23-47,107-156
Seq ID 142:pos.24-53
相应的肽或其片段(例如交迭15-mers)能够被合成并被检测其在体外结合多种人白细胞抗原分子。他们的免疫原性通过评价(抗原)肽诱导T细胞体外增殖(BrdU或3H-胸苷的合入)或分泌细胞因子(ELIspot,细胞内细胞因子染色)来检测(1996年Mayer等,2000年Schmittel等,2000年Sester等)。在这种情况下,在具有不同葡萄球菌感染,或菌群的患者、相对最近未被感染或无菌落的健康个体的群体中,检测T细胞对葡萄球菌抗原,或所选杂交肽或其片段反应的差别是有意义的。而且,期待抗体效价与在这些人群中观察到的T细胞反应的质量和数量呈现相关性。或者,预测的肽的免疫原性可在人白细胞抗原转基因小鼠上检测(1999年Sonderstrup等)。
在葡萄球菌抗原中鉴定人白细胞抗原I型限制的表面抗原决定簇,采用相似的方法。
合成肽代表一或多种来自金黄色葡萄球菌的杂交T辅助细胞表面抗原决定簇。
合成了跨越下列已知区域的部分交迭蛋白:Seq ID 56(LPXTGV),Seq ID 70(LPXTGIV),Seq ID 74(ORF1hom1),Seq ID 81(EM_BP),Seq ID 83(自溶素),Seq ID 89(ORF1hom2),Seq ID 94(EMPBP),Seq ID 114(POV2),和Seq ID 142(LPXTGVI)。表5中列出了不同肽的序列。所有多肽使用Fmoc化学方法合成,HPLC纯化,MS分析。冻干的肽溶解于DMSO于-20℃下以10-20mM的浓度保存。
代表杂交T辅助细胞表面抗原决定簇的合成肽体外结合人白细胞抗原分子。
在,肽结合到抗原呈递细胞表面的人白细胞抗原分子是T细胞活化的先决条件。体外通过使用重组的可溶性人白细胞II型抗原分子的二个独立的生化分析来评定这种结合。一个方法测定被检验的肽浓度依赖地竞争性置换标记的参考肽。另方法基于一旦结合高度和中等亲和力的配体生成的SDS稳定的复合物。表5中列出了由这二种分析方法得到的结果。
可溶性人白细胞抗原分子(DRA1*0101/DRB1*0101和DRA1*0101/DRB1*0401)在SC-2细胞中表达,按照1997年Aichinger等提到的方法纯化。对于竞争性分析(1995年Hammer等),每孔加入了50-200ng的人白细胞抗原分子。对于DRB1*0101,生物素酰化的指示肽HA以0.008uM使用(PKYVKQNTLKLAT,1993年Valli等)。对于DRB1*0401,生物素酰化的指示肽UD4以0.03-0.06uM使用(YPKFVKQNTLKAA,1993年Valli等)。被检验的肽以一系列0.02nM-200uM的稀释应用。分子、指示蛋白和检测的肽在pH7,37℃过夜培养。用一系列稀释的检测和参考肽(已知的高亲和性结合物HA和UD4作为阳性对照)孵育后获得的HLA:肽复合物在包被有L243抗体的ELISA平板中被捕捉,已知该抗体识别仅由正确相联的异二聚体生成的构像抗原决定簇。结合的生物素用标准比色法检测,使用带有NBT/BCIP片(Sigma)作为底物的链霉抗生物素-碱性磷酸酶缀合物(Dako),和自动Victor OD值读取仪。
通过IFNg ELIspot分析来评价对杂交T辅助细胞表面抗原决定簇的T细胞反应
一旦受到抗原刺激,T细胞就开始扩增并分泌细胞因子如γ干扰素(IFNg)。用IFNg-ELIspot方法检测金黄色葡萄球菌抗原内人T细胞特异性识别的抗原决定簇(2000年Schmittel等)。来自具有强抗金黄色葡萄球菌IgG反应的健康个体的PBMC通过聚糖体(ficoll)密度梯度离心从50-100ml静脉血液分离得到,冷冻并解冻后使用。在96孔板上以每孔200000的量接种细胞。相应于个体抗原加入肽混合物,2种情况中量各为10ug/ml。伴刀球蛋白A(Amersham)和PPD(结核菌素纯化的蛋白衍生物,Statens Serum研究所)作为分析的阳性对照,不含有肽的分析培养基作为阴性对照。在用抗人IFNg单抗B140(Bender Med Systems)包被的多重筛选96孔过滤板中过夜培养后,用生物素酰化的抗人IFNg单抗B308-BT2(Bender Med Systems),链霉抗生物素-碱性磷酸酶缀合物(DAKO)和BCIP/NBT碱性磷酸酶底物(SIGMA)显出ELIspot。使用自动平板读数器对平板的斑点进行计数(Bioreader 2000,BIO-SYS)。仅用分析培养基刺激细胞的读取点(阴性对照,总体上每100000个细胞底于10个点)作为背景,从用肽的孔中读取的点数中减去。
表5:金黄色葡萄球菌抗原中含有的杂交T辅助细胞表面抗原决定簇
含有高度杂交的T辅助细胞表面抗原决定簇的金黄色葡萄球菌抗原内的氨基酸序列 | 结合1) | IFNgELIspot2) |
Seq ID 56(LPXTGV):pos.6-40p6-28 >PKLRSFYSIRKSTLGVASVIVST//p24-40 >VIVSTLFLISQHQAQA// | +- | 44;80;8;95;112 |
Seq ID 56(LPXTGV):pos. 620-646p620-646 >FPYIPDKAVYNAIVKVVVANIGYEGQ// | + | |
Seq ID 56(LPXTGV):pos.871-896p871-896 >QSWWGLYALLGMLALFIPKFRKESK// | - | |
Seq ID 70(LPXTGIV):pos.24-53p24-53 >YSIRKFTVGTASILIGSLMYLGTQQEAEA// | nd | 34;14;0;57;16 |
Seq ID 74(ORF1hom1):pos.240-260p240-260 >MNYGYGPGVVTSRTISASQA//Seq ID 81(EM_BP):pos.1660-1682p1660-1682>NEIVLETIRDINNAHTLQQVEA// | +nd | 47;50;0;85;922;14;5;77;26 |
Seq ID 81(EM_BP):pos.1746-1790p1746-1773>LHMRHFSNNFGNVIKNAIGVVGISGLLA//p1753-1779 >NNFGNVIKNAIGVVGISGLLASFWFFI//p1777-1789 >FFIAKRRRKEDEE/ | ndndnd | |
Seq ID 83(Autolysin)pos.1-29p1-29: >MAKKFNYKLPSMVALTLVGSAVTAHQVQA// | nd | 6;35;7;60;49 |
Seq ID 83(Autolysin)pos.878-902p878-902:>NGLSMVPWGTKNQVILTGNNIAQG/ | nd | |
Seq ID 89(ORF1hom2):pos.96-136p96-121 >GESLNIIASRYGVSVDQLMAANNLRG//p117-136 >NNLRGYLIMPNQTLQIPNG// | -- | 0;35;0;29;104 |
Seq ID 94(EMPBP):pos.1-29p4-29: >KLLVLTMSTLFATQINNSNHAKASV// | + | |
Seq ID 94(EMPBP):pos.226-269p226-251 >IKINHFCVVPQINSFKVIPPYGHNS//p254-270 >MHVPSFQNNTTATHQN// | -+ |
26;28;16;43;97 | ||
Seq ID 94(EMPBP):pos.275-326p275-299 >YDYKYFYSYKVVKGVKKYFSFSQS//p284-305 >YKVVKGVKKYFSFSQSNGYKIG//p306-326 >PSLNIKNVNYQYAVPSYSPT// | +++ | |
Seq ID 114(POV2):pos.23-47p23-47 >AGGIFYNQTNQQLLVLCDGMGGHK// | - | 49;20;4;77;25 |
Seq ID 114(POV2):pos.107-156p107-124 >ALVFEKSVVIANVGDSRA/p126-146 >RAYVINSRQIEQITSDHSFVN//p142-158 >SFVNHLVLTGQITPEE// | -ndnd | |
Seq ID 142(LPXTGVI):pos.1-42p6-30 >KEFKSFYSIRKSSLGVASVAISTL//p18-42 >SSLGVASVAISTLLLLMSNGEAQA// | ++nd | 0;41;20;88;109 |
Seq ID 142(LPXTGVI):pos.209-244p209-233 >IKLVSYDTVKDYAYIRFSVSNGTKA//p218-244 >KDYAYIRFSVSNGTKAVKIVSSTHFNN// | ++ | |
Seq ID 142(LPXTGVI):pos.395-428p395-418 >FMVEGQRVRTISTYAINNTRCTIF//p416-428 >TIFRYVEGKSLYE//Seq ID 142(LPXTGVI):pos.623-647p623-647 >MTLPLMALLALSSIVAFVLPRKRKN// | --- | |
1)使用竞争性分析来确定与可溶性DRA1*0101/DRB1*0401分子的结合(+,
++:结合,-:对多达200uM检验的蛋白无竞争,nd:未做)
2)来自5个带有强抗金黄色葡萄球菌IgG反应的健康个体的结果,数据为每2000000个细胞的点数(背景已被减除)。
5.可将抗原注射给老鼠-并检测抗这些蛋白的抗体。
6.可在动物模型中评价由疫苗接种诱导的抗体的保护能力。
5和6中的方法为本领域技术人员熟知。
实施例7:应用
A)有效的疫苗为面临一般选择性外科手术的患者,特别是那些经历血管内仪器治疗的患者提供了非常重要选择可能。那些免疫反应降低的慢性病患者和进行连续流动腹膜透析患者可能得益于通过具有根据本发明的金黄色葡萄球菌免疫原型血清反应性抗原的疫苗。鉴定相关抗原会促进产生有效的被动免疫(人源化单抗治疗),这可以避免人免疫球蛋白治疗的所有危险的副作用。因此,有效的疫苗为面临一般选择性外科手术的患者,特别是那些经历血管内仪器治疗的患者提供了非常重要选择可能。
金黄色葡萄球菌可以引起多种疾病。
1.脓血病,菌血症
2.血液透析患者—菌血症,脓血病
3.腹膜透析患者—腹膜炎
4.使用血管内仪器的患者(心脏手术等)—内心膜炎,菌血症,脓血病
5.使用修复仪器进行整形外科手术的患者—败血性关节炎
6.对大量人群的预防性疫苗接种
B)被动和主动的疫苗接种,每种都需要特别关注T细胞,对于后者:为获得有效的体液反应和免疫记忆,在疫苗接种期,目标是引发强的T辅助细胞反应。现在还没有直接的证据说明T细胞在清除金黄色葡萄球菌感染中起重要作用,当然在这方面研究得还不够。抗蛋白抗原的有效体液反应必然涉及T辅助细胞,且它也是生成记忆的基础。天然CD4+细胞被分为Th1和Th2细胞。由于先天免疫反应(细胞因子)会影响这种决定,在急性严重感染中T细胞的涉及可能不同,相比与用不含有在天然感染过程中破坏免疫反应的组分的亚基疫苗免疫健康个体。这种诱导Th1或Th2反应的后果非常深刻。Th1细胞导致细胞免疫,Th2细胞产生体液免疫。
C)预防和治疗用疫苗
预防:在感染前,在高危人群中的主动接种疫苗和被动免疫。
治疗:对已经感染的患者被动接种疫苗。
主动接种疫苗来去掉鼻腔的携带。
应用的具体实施例
MRSA携带的清除和防止医疗人员感染带有菌落
医院外人群中鼻腔金黄色葡萄球菌携带率为10%-40%。医院中患者和医护人员具有较高的携带率。特别是在血液透析、糖尿病、药物依赖和多种皮肤病患者中比例较高。MRSA感染风险最高的人群在大的三级护理医院中,特别是那些老人、免疫妥协患者、重点看护病房中的患者、烧伤患者、有手术伤口的患者、和需要插入静脉内导管的患者。
ELISA数据强烈表明对于金黄色葡萄球菌存在明显的IgG反应,这在文献中没有被报道过。由于主要的粘膜免疫反应产生具有中和作用的IgA,显然用高纯度IgA制备物鉴定的葡萄球菌抗原决定簇和抗原能够导致有效的粘膜疫苗。
·清楚的指示:每个人在医院中经历手术时的危险(特别是整形外科,创伤科,总之是外科)
·明确的接种疫苗的人群(医生和护士)
·被鉴定为传染性金黄色葡萄球菌的鼻内携带者的看护人员在清除细菌之前服用莫披罗星和利福平。有时无效并浪费时间。
·有效的动物模型:建立了鼻内携带的老鼠模型。
表1.来自非感染个体的抗多种葡萄球菌蛋白的血清的ELISA效价。
通过进行标准ELISA检测抗葡萄球菌抗体水平,用生长于BHI培养基的金黄色葡萄球菌的总溶菌液,脂磷壁酸(LTA),肽聚糖(PG),13种重组蛋白,代表细胞表面和分泌至胞外的蛋白,如聚集因子A和B(ClfA,ClfB),纤维结合素结合蛋白(FnBPA),SD-重复蛋白(sdrC,sdrE),主要组织相容性复合物II型类似蛋白(map-w),弹性蛋白结合蛋白(EBP),烯醇酶(据报道位于细胞表面,具有免疫原性),铁转运脂蛋白(LP309,LP342),分类酶(srtA),凝固酶(coa),胞外纤维蛋白原结合蛋白(fib)。代表5个来自FnBPA的免疫D重复区域之2的两个短的合成肽作为抗原(D1+D3)被包括。根据IgG效价将来自不同个体血清分级,用1-9分来评价。1分表示最高效价血清,8分或9分表示在对给定抗原的所有检测血清中属于第8等或第9等。对前20个百分点的血清(8-9/40)进行了分析。根据1-8的评分数,以抗葡萄球菌抗体,选出反应活性最高的5个“最佳血清”。****表示抗体抗特异性抗原的反应性异常高(与2级反应活性的血清相比大于2倍ELISA单位)。
表2a:通过细菌表面和核糖体展示鉴定的免疫原蛋白:金黄色葡萄球菌
菌体表面展示:A,在fhuA中用患者血清1(655)的LSA250/1文库;B,lamB中用患者血清1(484)的LSA50/6文库;C,fhuA中用IC血清1(571)的LSA250/1文库;E,lamB中用IC血清2(454)的LSA50/6文库;F,lamB中用患者血清P1(1105)的LSA50/6文库;G,lamB中用IC血清1(471)的LSA50/6文库;H,fhuA中用患者血清1(IgA,708)的LSA250/1文库。核糖体展示:D,用IC血清(1686)的LSA250/1文库。*,经过33个筛选程序鉴定了18次;因此由筛选C中除去。**,用ANTIGENIC程序对大于5个氨基酸的抗原序列进行预测(1990年Kolaskar和Tongaonkar);#,在ORF中出现了2次的相同序列;##,数据库中没有的克隆(没有被TIGR测序)
表2b,通过细菌表面和核糖体展示鉴定的其它免疫原性蛋白:金黄色葡萄球菌
菌体表面展示:A,fhuA中用患者血清1(655)的LSA250/1库;B,lamB中用患者血清1(484)的LSA50/6库;C,fhuA中用IC血清1(571)的LSA250/1库;E,lamB中用IC血清2(454)的LSA50/6库;F,lamB中用患者血清P1(1105)的LSA50/6库;G,lamB中用IC血清1(471)的LSA50/6库;H,fhuA中用患者血清1(IgA,708)的LSA250/1库。核糖体展示:D,用IC血清(1686)的LSA250/1库。**,用ANTIGENIC程序对大于5个氨基酸的抗原性序列进行预测(1990年Kolaskar和Tongaonkar)。ORF,开放阅读框架;CRF,互补链上阅读框架;ARF,可变阅读框架。
表2c:通过细菌表面和核糖体展示鉴定的免疫原性蛋白:表皮葡萄球菌
细菌表面展示:A,fhuA中用患者血清2(957)的LSE150库;B,lamB中用患者血清2(1420)的LSE70库;C,lamB中用患者血清1(551)的LSE70库。核糖体展示:D,pMAL4.31中用P2(1235)的LSE150库。**,用ANTIGENIC程序对大于5个氨基酸的抗原性序列进行预测(1990年Kolaskar和Tongaonkar)。ORF,开放阅读框架;CRF,互补链上阅读框架;ARF,可变阅读框架。
表2d,通过细菌表面和核糖体展示鉴定的免疫原性蛋白:金黄色葡萄球菌(新注解)
菌体表面展示:A,fhuA中用患者血清1(655)的LSA250/1库;B,lamB中用患者血清1(484)的LSA50/6库;C,fhuA中用IC血清1(571)的LSA250/1库;E,lamB中用IC血清2(454)的LSA50/6库;F,lamB中用患者血清P1(1105)的LSA50/6库;G,lamB中用IC血清1(471)的LSA50/6库。核糖体展示:D,用IC血清(1686)的LSA250/1库。**,用ANTIGENIC程序对大于5个氨基酸的抗原序列进行预测(1990年Kolaskar和Tongaonkar);#,在ORF中出现了2次的相同序列。
表3,使用人血清对金黄色葡萄球菌表面蛋白进行血清学蛋白质组分析
a)逆境条件下的金黄色葡萄球菌agr株
b)标准条件下的金黄色葡萄球菌COL株
c)逆境条件下的金黄色葡萄球菌COL株
表4,通过MALDI-TOF-MS测序鉴定的金黄色葡萄球菌抗原(折叠的ORF也通过细菌表面展示鉴定)。对选定的用人血清通过血清学蛋白质组所鉴定的抗原的抗原性区域进行预测
1)用标准条件下生长的金黄色葡萄球菌8325-4 spa-的全溶菌液进行鉴定。血清反应活性用1/1患者和2/4正常血清,但不用婴儿血清(C5)。
表1.来自非感染个体的抗多种葡萄球菌蛋白的血清的ELISA效价
Sera ID# | BHI裂解液 | LTA | PG | ClfA | D1+D3 | FnBPA | sdrE | sdrC | EBP | 烯醇酶 | LP309 | LP342 | coagul | Fib | SrtA | ClfB | Map-w |
1 | |||||||||||||||||
2 | 2......... | 2......... | 8......... | 4......... | 6......... | 3......... | |||||||||||
3 | 7.......... | 3......... | 1......... | 1......... | 3......... | 2......... | 2......... | 2......... | 3......... | 7......... | 4......... | ||||||
4 | 1****** | 1****** | 1......... | 6......... | 2......... | 2......... | 3........ | 6......... | 2......... | 6,7....... | 8......... | 3......... | 4......... | 1......... | 3......... | ||
5 | |||||||||||||||||
6 | 4......... | 5......... | |||||||||||||||
7 | 6......... | 7......... | 7......... | 5......... | 4......... | 7......... | |||||||||||
8 | 8......... | 8......... | 5......... | 7......... | 8,9....... | ||||||||||||
9 | 4,5,6.... | 4......... | 5......... | 5......... | 6......... | 3......... | 1......... | 3,4...... | 1......... | 5,6....... | |||||||
10 | 5,6....... | ||||||||||||||||
11 | 6......... | 6......... | |||||||||||||||
12 | 4,5...... | ||||||||||||||||
13 | 5......... | 2......... | 8......... | ||||||||||||||
14 | |||||||||||||||||
15 | 3......... | 5......... | 2,3....... | 5......... | 6......... | 7......... | 8......... | 8,9....... | |||||||||
16 | 6......... | ||||||||||||||||
17 | |||||||||||||||||
18 | 6,7....... | 1......... | 3......... | 4......... | |||||||||||||
19 | 1......... | ||||||||||||||||
20 | |||||||||||||||||
21 | 2......... | 2......... |
Sera ID# | BHI裂解液 | LTA | PG | ClfA | D1+D3 | FnBPA | sdrB | sdrC | EBP | 烯醇酶 | LP309 | LP342 | coagul | Fib | SrtA | ClfB | Map-w |
22 | |||||||||||||||||
23 | 4,5,6.... | 5......... | 3......... | 6......... | 2......... | 7......... | 4......... | 6,7....... | 7......... | 6,7....... | 2......... | 2......... | |||||
24 | 4........ | 6......... | 8,9....... | ||||||||||||||
25 | 5......... | ||||||||||||||||
26 | 8......... | 7......... | |||||||||||||||
27 | 8......... | 4......... | 4,5....... | 4,5....... | 5......... | ||||||||||||
28 | |||||||||||||||||
29 | 1......... | ||||||||||||||||
30 | |||||||||||||||||
31 | 1......... | 1......... | 1......... | ||||||||||||||
32 | 4......... | ||||||||||||||||
33 | 8......... | 4......... | 4......... | 5......... | |||||||||||||
34 | 7,8....... | 2......... | 2......... | 1......... | 6,7....... | 6......... | 1......... | ||||||||||
35 | 4,5,6.... | 8......... | 2,3....... | 5......... | 1****** | 3......... | 4......... | ||||||||||
36 | 3......... | ||||||||||||||||
37 | 7......... | 7,8....... | 3.......... | ||||||||||||||
38 | 8......... | 3,4...... | |||||||||||||||
39 | |||||||||||||||||
40 | 7......... | 6,7....... | 3......... | 4,5....... | 8,9....... |
表2a:通过细菌表面和核糖体展示鉴定的免疫原蛋白:金黄色葡萄球菌
金黄色葡萄球菌抗原性蛋白 | 原 有 ORF序 号 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq ID no:(DNA+Prot) |
SaA0003 | ORF2963P | repC | 5-20,37-44,52-59,87-94,116-132 | C:3 | aa 112-189 | C:GSBYM94(112-189):26/30 | 171,172 |
SaA0003 | ORF2967P | repC | 7-19,46-57,85-91,110-117,125-133,140-149,156-163,198-204,236-251,269-275,283-290,318-323,347-363 | C:18 | aa 9-42aa 158-174 | C:GSBY153(9-42):1/1 | 150,158 |
0093 | ORF1879 | SdrC | 23-51,75-80,90-99,101-107,151-157,173-180,186-205,215-226,239-263,269-274,284-304,317-323,329-336,340-347,360-366372-379,391-397,399-405,413-425,430-436,444-455,499-505,520-529,553-568,586-592,600-617,631-639,664-678,695-701,891-903,906-912,926-940 | A:1,D:5,C:1,F:6,G:2 | aa 98-182aa 684-764aa 836-870 | A:GSBXL70(98-182):9/30D:n.d.C:GSBYH73(815-870):3/16 | 34,86 |
0095 | ORF1881 | SdrE | 25-45,72-77,147-155,198-211,217-223,232-238,246-261,266-279,281-294,299-304,332-340,353-360,367-380,384-396,404-409,418-429,434-440,448-460,465-476,493-509,517-523,531-540,543-555,561-566,576-582,584-591,603-617,633-643,647-652,668-674,677-683,696-704,716-728,744-752,755-761,789-796,809-815,826-840,854-862887-903,918-924,1110-1116,1125-1131,1145-1159 | C:12,E:2 | aa 147-192 | C:GSBYH31(147-192):2/14E:GSBZA27(144-162:23/41 | 145,153 |
0123 | ORF1909 | 未知 | 9-28,43-48,56-75,109-126,128-141,143-162,164-195,197-216,234-242,244-251 | B:3,E:7G:1 | aa 168-181 | B:GSBXF80(168-181):5/27E:GSBZC17(168-181):25/41 | 35,87 |
0160 | ORF1941 | 未知 | 4-10,20-42,50-86,88-98,102-171,176-182,189-221,223-244,246-268,276-284,296-329 | A:1 | aa 112-188 | A:GSBXO07(112-188):5/30 | 36,88 |
0222 | ORF1988 | 与..同源ORF1 | 4-9,13-24,26-34,37-43,45-51,59-73,90-96,99-113,160-173,178-184,218-228,233-238,255-262 | A:52,C:18*,H:19 | aa 45-105aa 103-166aa 66-153 | A:GSBXM63(65-95):1/1A:GSBXM82(1O3-166):14/29A:GSBXK44-bmd3(65-153):47/51 | 37,89 |
0308 | ORF2077 | 补体,未知 | 13-27,42-63,107-191,198-215,218-225,233-250 | A:6,B:2,C:47,E:35 | 补体bp474-367 | A:GSBXK03(bp473-367):28/69B:GSBXD29(bp465-431):10/27 | 38,90 |
金黄色葡萄球菌抗的性蛋白 | 原有ORF序号 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq ID no:(DNA+Prot) |
0317 | ORF2088 | 前蛋白转移酶seca亚基 | 16-29,64-77,87-93,95-101,127-143,150-161,204-221,225-230,236-249,263-269,281-309,311-325,337-343,411-418,421-432,435-448,461-467,474-480,483489,508-516,542-550,580-589,602-611,630-636,658-672,688-705,717-723,738-746,775-786,800-805,812-821,828-834 | A:1 | aa 1-19 | A:GSBXP37(1-19):6/29 | 39,91 |
0337 | ORF2110 | 假定的蛋白 | 26-53,95-123,164-176,189-199 | D:12 | aa 8-48 | D:n.d. | 40,92 |
0358 | ORF2132 | 聚集因子A | 8-35,41-48,59-66,87-93,139-144,156-163,198-209,215-229,236-244,246-273,276-283,285-326,328-342,349-355,362-370,372-384,396-402,405-415,423-428,432-452,458-465,471-477,484-494,501-515,540-547,554-559,869-875,893-898,907-924 | C:1,D:2,E:1 | aa 706-809 | D:n.d. | 41,93 |
0360 | ORF2135Empbp | 细胞外基质和细胞质结合蛋白 | 7-13,15-23,26-33,68-81,84-90,106-117,129-137,140-159,165-172,177-230,234-240,258-278,295-319 | A:46,B:21,C:11,E:2,F:18,G:7,H:12 | aa 22-56aa 23-99aa 97-115aa 233-250aa 245-265 | A:GSBXK24(23-55):1/1B:GSBXB43(39-54):58/71A:GSBXK02-bmd1(22-99):59/59B:GSBXD82-bdb19(97-115):1/1F:SALAL03(233-250):15/41 | 42,94 |
0453 | ORF2227 | 昏迷操纵子2 | 17-25,27-55,84-90,95-101,115-121 | C:3 | aa 55-101 | C:GSBYG07(55-101):1/1 | 146,154 |
0569 | ORF1640 | V8 蛋白酶 | 5-32,66-72,87-98,104-112,116-124,128-137,162-168,174-183,248-254,261-266,289-303,312-331 | A:1,F:1 | aa 174-249 | A:GSBXS51(174-249):11/30 | 32,84 |
金黄色葡萄球菌抗原性蛋白 | 原有ORF序号 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq ID no:(DNA+Prot) |
0576 | ORF1633自溶素 | 自溶素,附着 | 4-19,57-70,79-88,126-132,144-159,161-167,180-198,200-212,233-240,248-255,276-286,298-304,309-323,332-346,357-366,374-391,394-406,450-456,466-473,479-487,498-505,507-519,521-530,532-540,555-565,571-581,600-611,619-625,634-642,650-656,658-665,676-682,690-699,724-733,740-771,774-784,791-797,808-815,821-828,832-838,876-881,893-906,922-929,938-943,948-953,969-976,1002-1008,1015-1035,1056-1069,1105-1116,1124-1135,1144-1151,1173-1181,1186-1191,1206-1215,1225-1230,1235-1242 | A:21,B:46,C:55,E:5,F:85,H:19 | aa 6-66aa65-124aa 579-592aa 590-604 | A:GSBXN93(6-66):5/16C:GSBYH05(45-144):7/8A:GSBXK66-bmd18(65-124):16/30B:GSBXB89(108-123):1/1B:GSBXB02(590-603):39/71F:SALAM15(579-592):25/41 | 31,83 |
0657 | ORF un-未知 | LPXTGVI蛋白 | 9-33,56-62,75-84,99-105,122-127,163-180,186-192,206-228,233-240,254-262,275-283,289-296,322-330,348-355,416-424,426-438,441-452,484-491,541-549,563-569,578-584,624-641 | A:2,B:27,F:15 | aa 527-544 | B:GSBXB07-bdb1(527-542):11/71F:SALAX70(526-544:11/41 | 1,142 |
0749 | ORF1462 | 氨基甲酰-磷酸盐合成酶 | 8-23,31-38,42-49,61-77,83-90,99-108,110-119,140-147,149-155,159-171,180-185,189-209,228-234,245-262,264-275,280-302,304-330,343-360,391-409,432-437,454-463,467-474,478-485,515-528,532-539,553-567,569-581,586-592,605-612,627-635,639-656,671-682,700-714,731-747,754-770,775-791,797-834,838-848,872-891,927-933,935-942,948-968,976-986,1000-1007,1029-1037 | C:2 | aa 630-700 | C:GSBYK17(630700):5/9 | 144,152 |
944 | ORF1414 | Yfix | 6-33,40-46,51-59,61-77,84-104,112-118,124-187,194-248,252-296,308-325,327-361,367-393,396-437,452-479,484-520,535-545,558-574,582-614,627-633,656-663,671-678,698-704,713-722,725-742,744-755,770-784,786-800,816-822,827-837 | D:4 | aa 483-511 | D:n.d. | 30,82 |
1050 | ORF1307 | 未知 | 49-72,76-83,95-105,135-146,148-168,183-205 | A:1,H:45 | aa 57-128 | A:GSBXM26(57-128):7/30 | 28,80 |
金黄色葡萄球菌抗原性蛋白 | 原有ORF序号 | 推定的功能(以同原性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq ID no:(DNA+Prot) |
1209 | ORF3006 | bcmN 同源物 | 12-36,43-50,58-65,73-78,80-87,108-139,147-153,159-172,109-203,211-216,224-232,234-246,256-261,273-279,286-293,299-306,340-346,354-366 | B:7,F:8 | aa 167-181 | B:GSBXB76(16-179):25/71F:SALBC54(169-183):18/41 | 54,106 |
1344 | ORF0212 | NifS 蛋白同源物 | 8-16,22-35,49-58,70-77,101-121,123-132,147-161,163-192,203-209,216-234,238-249,268-274,280-293,298-318,328-333,339-345,355-361,372-381 | A:11 | aa 34-94 | A:GXBXK59-bmd21(34-94):6/29 | 5,141 |
1356 | ORF0197 | 假定的蛋白酶 | 28-55,82-100,105-111,125-131,137-143 | D:12 | aa 1-49 | D:n.d. | 4,57 |
1361 | ORF0190 | LPXTGV蛋白 | 5-39,111-117,125-132,134-141,167-191,196-202,214-232,236-241,244-249,292-297,319-328,336-341,365-380,385-391,407-416,420-429,435-441,452-461,477-488,491-498,518-532,545-556,569-576,581-587,595-602,604-609,617-640,643-651,702-715,723-731,786-793,805-811,826-839,874-889 | A:1,B:23,E:3,F:31 | aa 37-49aa 63-77aa 274-334 | B:GSBXF81(37-49):1/1B:GSBXD45-bdb4(62-77):12/70A:GSBXL77(274-334):5/30F:SALAP81(62-77):10/411 | 3,56 |
1371 | ORF0175 | YtpT,保守的假定的蛋白 | 37-42,57-62,121-135,139-145,183-190,204-212,220-227,242-248,278-288,292-30,304-309,335-341,396-404,412-433,443-449,497-503,505-513,539-545,552-558,601-617,629-649,702-711,736-745,793-804,814-829,843-858,864-885,889-895,905-913,919-929,937-943,957-965,970-986,990-1030,1038-1049,1063-1072,1080-1091,1093-1116,1126-1136,1145-1157,1163-1171,1177-1183,1189-1196,1211-1218,1225-1235,1242-1256,1261-1269 | C:3,E:2,G:1 | aa 624-684aa 891-905 | C:GSBYG95(624-684):7/22E:GSBZB45(891-905):10/41 | 143,151 |
1491 | ORF0053 | 结合因子1同源物 | 12-29,34-40,63-71,101-110,114-122,130-138,140-195,197-209,215-229,139-253,255-274 | A:7,C:2,E:7,F:4 | aa 39-94 | A:GSBXM13(39-94):10/29F:SALAY30(39-53):4/41 | 2,55 |
1616 | ORF1180 | 杀白细胞素F同源物 | 16-24,32-39,43-49,64-71,93-99,126-141,144-156,210-218,226-233,256-273,276-284 | A:10 | aa 158-220 | A:GSBXK06(158-220):8/29 | 27,79 |
1618 | ORF1178 | LukM 同源物 | 5-24,88-94,102-113,132-143,163-173,216-224,254-269,273-278,305-313,321-327,334-341 | A:13,B:3C:36,E:4,F:12,G:2,H:10 | aa 31-61aa 58-74 | A:GSBXK60(31-61):20/29B:GSBXB48(58-74):49/71F:SALAY41(58-74):30/41 | 26,78 |
金黄色葡萄球菌抗原性蛋白 | 原有ORF序号 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq ID no:(DNA+Prot) |
1632 | ORF1163 | SdrH同源物 | 7-35,54-59,247-261,263-272,302-320,330-339,368-374,382-411 | B:6,E:11,F:34 | aa 105-119aa 126-143aa 168-186 | B:GSBXG53(168-186):39/71F:SALAP07(105-119):11/41 | 25,77 |
1763 | ORF1024 | 未知 | 5-32,35-48,55-76 | C:3 | Complementbp 237-170 | C:GSBY130(98aa):1/1 | 24,76 |
1845 | ORF0942 | 透明质酸(裂解)酶 | 10-26,31-44,60-66,99-104,146-153,163-169,197-205,216-223,226-238,241-258,271-280,295-315,346-351,371-385,396-407,440-446,452-457,460-466,492-510,537-543,546-551,565-582,590-595,635-650,672-678,686-701,705-712,714-721,725-731,762-768,800-805 | D:5,F: 2 | aa 208-224aa 672-727 | D:n.d. | 23,75 |
1951 | ORF0831 | 与.同源ORF1 | 5-22,42-50,74-81,139-145,167-178,220-230,246-253,255-264 | A:223,B:56,C:167,E:43,F:100,G:13,H:102 | aa 137-237aa 250-267 | B:GSBXC07(180-190):1/1A;GSBXK29(177-195):15/29B:GXBXD43(250-267):10/71F:SALAM13(178-191):20/41 | 22,74 |
1955 | ORF0826 | 与.同源ORF1 | 4-9,15-26,65-76,108-115,119-128,144-153 | A:1,B:3,E:1,F:8 | aa 38-52.aa 66-114 | A:GSBXR10(66-114):5/30F:SALAM67(37-52):16/41 | 21,73 |
2031 | ORF0749 | 未知 | 10-26,31-43,46-58,61-66,69-79,85-92,100-115,120-126,128-135,149-155,167-173,178-187,189-196,202-222,225-231,233-240,245-251,257-263,271-292,314-322,325-334,339-345 | B:2,F:2 | aa 59-74 | B:GSBXC01(59-71):11/26 | 20,72 |
2086 | ORF0691Sbi | IgG结合蛋白 | 6-20,53-63,83-90,135-146, 195-208,244-259,263-314,319-327,337-349,353-362,365-374,380-390,397-405,407-415 | A:1,B:8,E:24,F:9,G:137 | aa 208-287aa 261-276aa 286-314 | A:GSBXS55(208-287):38/46B:GSBXB34(299-314:11/71F:SALAX32(261-276):21/41 | 19,71 |
金黄色葡萄球菌抗原性蛋白 | 原有ORF序号 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq ID no:(DNA+Prot) |
2180 | ORF0594 | LPXTGIV蛋白 | 11-20,26-47,69-75,84-92,102-109,119-136,139-147,160-170,178-185,190-196,208-215,225-233,245-250,265-272,277-284,300-306,346-357,373-379,384-390,429-435,471-481,502-507,536-561,663-688,791-816,905-910,919-933,977-985,1001-1010,1052-1057,1070-1077,1082-1087,1094-1112 | A:3,C:3,E:6,F:2,H:6 | aa 493-587aa 633-715aa 704-760aa 760-832(aa 832-887)# | A:GSBXS61(493-555):1/1A:GSBXL64(496-585):1/1A:GSBXS92(760-841):1/1.A:bmd4(704-760):16/30#(A:bmd4(830-885):16/30)#F:SALBC43(519-533):4/41 | 18,70 |
2184 | ORF0590 | FnbpB | 5-12,18-37,104-124,139-145,154-166,175-181,185-190,193-199,203-209,235-244,268-274,278-292,299-307,309-320,356-364,375-384,390-404,430-440,450-461,488-495,505-511,527-535,551-556,567-573,587-593,599-609,624-631,651-656,664-671,714-726,754-766,799-804,818-825,827-833,841-848,855-861,876-893,895-903,927-940 | A:2,C:4,G:9 | aa 701-777aa 783-822 | A:GSBXM62(702-777):28/28A:GSBXR22(783-855):1/1 | 17,69 |
2186 | ORF0588 | Fnbp | 8-29,96-105,114-121,123-129,141-147,151-165,171-183,198-206,222-232,253-265,267-277,294-300,302-312,332-338,362-368,377-383,396-402,410-416,451-459,473-489,497-503,537-543,549-559,581-600,623-629,643-649,655-666,680-687,694-700,707-712,721-727,770-782,810-822,874-881,883-889,897-903,911-917,925-931,933-939,946-963,965-973,997-1010 | A:4,C:4,D:5,E:2 | aa 710-787aa 855-975aa 916-983 | C:GSBYN05(710-787):19/25D:n.d.A:GSBXP01(916-983):17/30 | 16,68 |
2224 | ORF0551 | 未知 | 49-56,62-68,92-98,109-115,124-131,142-159,161-167,169-175,177-188,196-224,230-243,246-252 | B:2 | aa 34-46 | B:GSBXD89(34-46):1/1 | 15,67 |
金黄色葡萄球菌抗原性蛋白 | 原有ORF序号 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq ID no:(DNA+Prot) |
2254 | ORF0519 | 保守的假定蛋白 | 14-22,32-40,52-58,61-77,81-93,111-117,124-138,151-190,193-214,224-244,253-277,287-295,307-324,326-332,348-355,357-362,384-394,397-434,437-460,489-496,503-510,516-522,528-539,541-547,552-558,563-573,589-585,602-624,626-632,651-667,673-689,694-706,712-739,756-790 | D:3 | aa 403-462 | D.n.d. | 14,66 |
2264 | ORF0509 | ORF1;与来自表皮葡萄球菌的推定的分泌型抗原前体同源 | 5-31,47-55,99-104,133-139,156-172,214-224,240-247 | A:131,B:51,C:13,E:43,F:78,G:2,H:17 | aa 7-87aa 131-242 | A:GSBXP22(145-196):1/1A:GSBXK05-bmd16(178-218):6/29B:GSBXE24-bdb20(167-178):1/1F:SALAQ91(173-184):15/41 | 13,65 |
2268 | ORF0503 | IsaA,可能黏附/聚集 | 7-19,26-45,60-68,94-100,111-119,126-137,143-148,169-181,217-228 | A:7,B:65,C:3,E:2,F:53 | aa 67-116aa 98-184aa 182-225 | A:GSBXK88(67-116):1/1A:GSBXN19(98-184):22/29A:GSBXN32(182-225):34/71B:GSBXB71(196-209):16/29F:SALAL22(196-210):16/41 | 12,64 |
2344 | ORF0426 | 聚集因子B | 4-10,17-45,120-127,135-141,168-180,187-208,216-224,244-254,256-264,290-312,322-330,356-366,374-384,391-414,421-428,430-437,442-449,455-461,464-479,483-492,501-512,548-555,862-868,871-876,891-904 | D:9,E:1,F:3,H:4 | aa 706-762aa 810-852 | D:n.d. | 11,63 |
2351 | ORF0418 | sureolysin | 10-29,46-56,63-74,83-105,107-114,138-145,170-184,186-193,216-221,242-248,277-289,303-311,346-360,379-389,422-428,446-453,459-469,479-489,496-501 | A:1,C:6 | aa 83-156 | A:GSBXO46(83-156):14/29 | 10,62 |
金黄色葡萄球菌抗原性蛋白 | 原有ORF序号 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq ID no:(DNA+Prot) |
2359 | ORF0409 | ISSP,推定的分泌型免疫原性蛋白前体 | 4-29,92-99,119-130,228-236,264-269,271-280,311-317,321-331,341-353,357-363,366-372,377-384,390-396,409-415,440-448,458-470,504-520,544-563,568-581,584-592,594-603,610-616 | B:4,F:11 | aa 168-184aa 206-220aa 297-309 | B:GSBXD01(168-184):1/1B:GSBXD62(205-220):1/1B:GSBXC17(297-309):6/27F:SALAL04(205-220):9/41 | 9,61 |
2378 | ORF0398 | SrpA | 18-23,42-55,69-77,85-98,129-136,182-188,214-220,229-235,242-248,251-258,281-292,309-316,333-343,348-354,361-367,393-407,441-447,481-488,493-505,510-515,517-527,530-535,540-549,564-583,593-599,608-621,636-645,656-670,674-687,697-708,726-734,755-760,765-772,785-792,798-815,819-824,826-838,846-852,889-904,907-913,932-939,956-964,982-1000,1008-1015,1017-1024,1028-1034,1059-1065,1078-1084,1122-1129,1134-1143,1180-1186,1188-1194,1205-1215,1224-1230,1276-1283,1333-1339,1377-1382,1415-1421,1448-1459,1467-1472,1537-1545,1556-1566,1647-1654,1666-1675,1683-1689,1722-1737,1740-1754,1756-1762,1764-1773,1775-1783,1800-1809,1811-1819,1839-1851,1859-1866,1876-1882,1930-1939,1947-1954,1978-1985,1999-2007,2015-2029,2080-2086,2094-2100,2112-2118,2196-2205,2232-2243 | C:1,D:7,F:4,H:11 | aa 198-258aa 646-727aa 846-857aa 2104-2206 | C:GSBY173(646-727):2/9F:SALAO33(846-857):10/41D:n.d. | 8,60 |
2466 | ORF0302 | YycH蛋白 | 16-38,71-77,87-94,135-112,124-144,158-164,169-177,180-186,194-204,221-228,236-245,250-267,336-343,363-378,385-394,406-412,423-440,443-449 | D:14 | aa 401-494 | D:n.d. | 7,59 |
2470 | ORF029 | 保守的假定蛋白 | 4-9,17-41,50-56,63-69,82-87,108-115,145-151,207-214,244-249,284-290,308-316,323-338,348-358,361-378,410-419,455-451,512-522,527-533,540-546,553-558,561-575,601-608,632-644,656-667,701-713,727-733,766-780 | C:3 | aa 414-455 | C:GSBYH60(414-455):28/31 | 169,170 |
金黄色葡萄球菌抗原性蛋白 | 原有ORF序号 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq ID no:(DNA+Prot) |
2498 | ORF0267 | 保守的假定蛋白 | 33-3,45-51,57-63,65-72,80-96,99-110,123-129,161-171,173-179,85-191,193-200,208-224,227-246,252-258,294-308,321-329344-352,691-707 | D:12 | aa 358-411aa 588-606 | D:17/21 | 6,58 |
2548 | ORF2711 | IgG结合蛋白A | 4-16,24-57,65-73,85-91,95-102,125-132,146-152,156-163,184-190,204-210,214-221,242-252,262-268,272-279,300-311,320-337,433-440,472-480,505-523 | A:55,B:54C:35,F:59G:56H:38 | aa 1-48aa 47-143aa 219-285aa 345-424 | A:GSBXK68(1-73):21/30A:GSBXK41(47-135):1/1A:GSBXN38(219-285):19/30A:GSBXL11(322-375):10/30B:GSBXB22(406-418):37/71F:SALAM17(406-418):29/41 | 53,105 |
2577 | ORF2683 | 假定蛋白 | 4-21,49-56,65-74,95-112,202-208,214-235 | C:6 | aa 99-171 | C:GSBYL56(99-171):1/1 | 149,157 |
2642 | ORF2614 | 未知 | 34-58,63-69,74-86,92-101,130-138,142-150,158-191,199-207,210-221,234-249,252-271 | C:1,E:1 | aa 5-48 | C:bbe3(5-48):25/30## | 52,104 |
2664 | ORF2593 | 保守的假定蛋白 | 7-7,56-71,74-150,155-162,183-203,211-222,224-234,242-272 | D:35 | aa 77-128 | D:n.d. | 51,103 |
2670 | ORF2588 | 己糖转运酶 | 18-28,36-49,56-62,67-84,86-95,102-153,180-195,198-218,254-280,284-296,301-325,327-348,353-390,397-402,407-414,431-455 | D:16 | aa 328-394 | D:n.d. | 50,102 |
2680 | ORF2577 | 凝固酶 | 4-18,25-31,35-40,53-69,89-102,147-154,159-165,185-202,215-223,284-289,315-322,350-363,384-392,447-453,473-479,517-523,545-550,572-577,598-604,617-623 | C:26,G:4,H:8 | aa 438-516aa 505-570aa 569-619 | C:GSBYH16(438-516):3/5C:GSBYG24(505-570):1/7C:GSBYL82(569-619):2/7 | 148,156 |
2740 | ORF2515 | 假定蛋白 | 5-44,47-55,62-68,70-78,93-100,128-151,166-171,176-308 | D:4 | aa 1-59 | D:n.d. | 49,101 |
2746 | ORF2507 | 与同源ORF1 | 5-12,15-20,43-49,94-106,110-116,119-128,153-163,175-180,185-191,198-209,244-252,254-264,266-273,280-288,290-297 | A:1,H:13 | aa 63-126 | A:GSBXO40(66-123):8/29 | 48,100 |
2797 | ORF2470 | 未知 | 10-27,37-56,64-99,106-119,121-136,139-145,148-178,190-216,225-249,251-276,292-297, 312-321,332-399,403-458 | B:3,E:2,F;13,H:3 | aa 183-200aa 349-363 | B:GSBXB85(183-200):11/27F:SALAQ47(183-200):8/41 | 47,99 |
金黄色葡萄球菌抗原性蛋白 | 原有ORF序号 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq ID no:(DNA+Prot) |
2798 | ORF2469 | 脂肪酶(geh) | 12-35,93-99,166-179,217-227,239-248,269-276,288-294,296-320,322-327,334-339,344-356,362-371,375-384,404-411,433-438,443-448,455-464,480-486,497-503,516-525,535-541,561-570,579-585,603-622,633-641 | A:41,B:42,C:3,F:35,G:1,H:11 | aa 48-136aa 128-172aa 201-258 | C:GSBYG01(48-136):2/6A:GSBXM31-bmd12(128-188):11/30B:GSBXE16(165-177):10/30A:GSBXN20(201-258):8/30F:SALAW05(165-177):13/41 | 46,98 |
2815 | ORF2451 | 保守的假定蛋白 | 5-32,34-49 | D:21 | aa 1-43 | D:n.d. | 45,97 |
2914 | ORF2351 | metC | 39-44,46-80,92-98,105-113,118-123,133-165,176-208,226-238,240-255,279-285,298-330,338-345,350-357,365-372,397-402,409-415,465-473,488-515,517-535,542-550,554-590,593-601,603-620,627-653,660-665,674-687,698-718,726-739 | A:1,C:14,F:2 | aa 386-402 | A:GSBXM18(386-402):17/29 | 44,96 |
2960 | ORF2298 | 推定的外毒素 | 13-36,40-49,111-118,134-140,159-164,173-183,208-220,232-241,245-254,262-271,280-286,295-301,303-310,319-324,332-339 | C:101,E:2,H:58 | aa 1-85aa 54-121aa 103-195 | C:GSBYG32(1-85):6/7C:GSBYG61-bbe2(54-121):26/30C:GSBYN80(103-195):13/17 | 43,95 |
2963 | ORF2295 | 推定的外毒素 | 13-28,40-46,69-75,86-92,114-120,126-137,155-172,182-193,199-206,213-221,232-238,243-253,270-276,284-290 | C:3,E:3,G:1 | aa 22-100 | C:GSBYJ58(22-100):9/15 | 147,155 |
3002 | ORF1704 | 与同源ORF1 | 4-21,28-40,45-52,59-71,92-107,123-137,159-174,190-202,220-229,232-241,282-296,302-308,312-331 | A:2,C:1,H:4 | aa 21-118 | A:GSBXL06(21-118):50/52 | 33,85 |
金黄色葡萄球菌抗原性蛋白 | 原有ORF序号 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq ID no:(DNA+Prot) |
3200 | ORF1331 | 推定的细胞外基质结合蛋白 | 6-15,22-32,58-73,82-88,97-109,120-131,134-140,151-163,179-185,219-230,252-255,271-277,288-293,305-319,345-356,368-381,397-406,408-420,427-437,448-454,473-482,498-505,529-535,550-563,573-580,582-590,600-605,618-627,677-685,718-725,729-735,744-759,773-784,789-794,820-837,902-908,916-921,929-935,949-955,1001-1008,1026-1032,1074-1083,1088-1094,1108-1117,1137-1142,1159-1177,1183-1194,1214-1220,1236-1252,1261-1269,1289-1294,1311-1329,1336-1341,1406-1413,1419-1432,1437-1457,1464-1503,1519-1525,1531-1537,1539-1557,1560-1567,1611-1618,1620-1629,1697-1704,1712-1719,1726-1736,1781-1786,1797-1817,1848-1854,1879-18901919-1925,1946-1953,1974-1979 | A:11,B:11,C:36 | aa 5-134 | A:GSBXL07(5-134):6/28 | 29,81 |
表2b,通过细菌表面和核糖体展示鉴定的其它免疫原性蛋白:金黄色葡萄球菌
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ARF0280 | 推定的蛋白 | 7-14 | F:6 | aa 25-43 | SALAM59(25-43):1/1 | 401,402 |
CRF0145 | 推定的蛋白 | 18-28,31-37,40-47,51-83,86-126 | F:5 | aa 81-90 | SALAZ40(81-90):2/12 | 403,404 |
CRF0250 | 推定的蛋白 | 4-24,26-46,49-86 | G:8 | aa 60-76 | SALAJ87(60-76):n.d. | 365,378 |
CRF0308 | 推定的蛋白 | 40-46 | A:6,B:2,C:47,E:35 | aa 5-38 | A:GSBXK03(7-36):28/69B;GSBXD29(10-20):10/27 | 391,392 |
CRF0337 | 未知 | 4-17 | D:3 | aa 1-20 | D:n.d. | 469;486 |
CRF0497 | 推定的蛋白 | 4-28,31-53,58-64 | B:13,F:5 | aa 18-34 | GSBXF31(19-34):1/7 | 366,379 |
CRF0538 | 未知 | 4-20 | D:7 | aa 1-11 | D:n.d. | 470;487 |
CRF0750 | 推定的蛋白 | 4-11,18-24,35-40 | G:44 | aa 25-39 | SALAG92(26-39):n.d. | 367,380 |
CRF1145 | 未知 | 4-57 | D:28 | aa 16-32 | D:n.d. | 464;481 |
CRF1247 | 推定的蛋白 | 4-25,27-56 | F:6 | aa 36-46 | SALAR23(36-46):n.d. | 368,381 |
CRF1256 | 推定的蛋白 | 19-25,38-47,55-74,77-87 | G:5 | aa 54-67 | SALAG65(54-67):n.d. | 369,3/82 |
CRF1356 | 未知 | 8-15;18-24;27-38 | D:5 | aa 5-33 | D:n.d. | 471;488 |
CRF1763 | 推定的蛋白 | 4-9,23-41,43-58,71-85 | C:3 | aa 1-22 | C:GSBYI30(1-22):1/1 | 407,408 |
CRF1783 | 未知 | 8-161 | D:5 | aa 76-127 | D:n.d. | 465;482 |
CRF1845 | 未知 | 4-28;30-36 | D:272 | aa 1-17 | D:n.d. | 472;489 |
CRF1861 | 未知 | 6-11;13-34;36-50 | D:8 | aa 4-27 | D:n.d. | 466;483 |
CRF1928 | 推定的蛋白 | 4-9,17-30 | F:9 | aa 13-22 | SALAR41(13-22):n.d. | 370,383 |
CRF2004 | 推定的蛋白 | 18-38 | F:13 | aa 16-32 | SALAM7516-32):n.d. | 371,384 |
CRF2155 | 推定的蛋白 | 4-15,30-58 | F:9 | aa 54-66 | SALAQ54(54-66):1/12 | 372,385 |
CRF2180 | 推定的蛋白 | 4-61,65-72,79-95,97-106 | E:13 | aa 86-99 | GSBZB08(86-99):n.d. | 373,386 |
CRF2207 | 未知 | 4-13 | D:3 | aa 17-39 | D:n.d. | 473;490 |
CRF2305 | 推定的蛋白 | 4-9,22-33,44-60 | C:5 | aa 80-116 | GSBYL75(80-116):n.d. | 374,387 |
CRF2341 | 推定的蛋白 | 4-23,30-44,49-70 | F:8 | aa 46-55 | SALAW31(46-55):n.d. | 375,388 |
CRF2349 | 推定的蛋白 | 4-32,39-46,62-69,77-83 | B:10,F:4 | aa 46-67 | GSBXC92(52-67):2/11 | 376,389 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
CRF2356 | 未知 | 4-18 | D:3 | aa 3-18 | D:n.d. | 475;492 |
CRF2452 | 未知 | 4-31 | D:9 | aa 7-21 | D:n.d. | 476;493 |
CRF2498 | 推定的蛋白 | 4-29,31-41 | G:8 | aa 2-15 | SALAF30(3-15):n.d. | 377,390 |
CRF2553 | 未知 | 4-35;37-42 | D:4 | aa 1-20 | D:n.d. | 474;491 |
CRF2578 | 未知 | 5-25;30-39 | ID:11 | aa 9-30 | D:n.d. | 467;484 |
CRF2664 | 未知 | 11-21 | D:17 | aa 1-14 | D:n.d. | 477;494 |
CRF2729 | 推定的蛋白 | 10-41,50-57 | F:3 | aa 40-56 | SALAQ25(40-56)1/1 | 405,406 |
CRF2863/1 | 未知 | 4-43 | D:78 | aa 17-40 | D:n.d. | 478;495 |
CRF2863/2 | 未知 | 4-46 | D:78 | aa 44-49 | D:n.d. | 479;496 |
CRFA002 | 未知 | 17-39;52-59 | D:3 | aa 38-55 | D:n.d. | 463;480 |
CRFN1 | 未知 | 5-20;37-44;52-59;87-94;116-132 | D:4 | aa 94-116 | D:n.d. | 468;485 |
ORF0188 | UDR-N-甘露D-糖胺转移酶,推定的 | 11-18,43-56,58-97,100-118,120-148,152-171,195-203,207-214,220-227,233-244 | B:4,F:29 | aa 197-210 | SALAM14(198-209):n.d. | 397,398 |
ORF0254 | 多种药物流出转运子 | 4-33,35-56,66-99,109-124,136-144,151-180,188-198,201-236,238-244,250-260,266-290,294-306,342-377 | D:3 | aa 155-175 | D:n.d. | 297,325 |
ORF0307 | 保守的假定蛋白 | 4-23,25-67,76-107,109-148 | D:3 | aa 9-44 | D:n.d. | 298,326 |
ORF0452 | 保守的假定蛋白 | 4-35,41-47,55-75,77-89,98-113,116-140,144-179,194-215,232-254,260-273,280-288,290-302,315-323,330-369,372-385,413-432 | D:5 | aa 105-122 | D:n.d. | 299,327 |
ORF0456 | Na+/H+反向转运体 | 4-81 | D:66 | aa 1-21 | D:n.d. | 300,328 |
ORF0556 | 铁(III)二柠檬酸盐结合蛋白 | 5-23,50-74,92-99,107-122,126-142,152-159,172-179,188-196,211-218,271-282 | D:10 | aa 1-18 | D:n.d. | 301,329 |
ORF0629 | 假定蛋白 | 9-44,63-69,75-82,86-106,108-146,153-161,166-178,185-192,233-239,258-266,302-307 | D:313 | aa 13-37 | D:n.d. | 302,330 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot |
ORF0637 | GTP-结合蛋白TypA | 10-19,22-32,95-105,112-119,121-33,140-154,162-174,186-200,207-224,238-247,254-266,274-280,288-294,296-305,343-351,358-364,366-373,382-393,403-413,415-422,440-447,499-507,565-575,578-588 | F:3 | aa 107-119 | F:SALAX70(107-119):10/41 | 393,395 |
ORF0713 | 推定的,保守假定穿膜蛋白 | 22-51,53-71,80-85,93-99,105-112,123-146,151-157,165-222,226-236,247-270,290-296,301-324,330-348,362-382,384-391,396-461,463-482,490-515 | D:3 | aa 487-513 | D:n.d. | 303,331 |
ORF0788 | 细胞分裂蛋白 | 104-111,158-171,186-197,204-209,230-247,253-259,269-277,290-314,330-340,347-367,378-388 | D:4 | aa 152-178 | D:n.d. | 304,332 |
ORF0797 | 保守的假定蛋白 | 11-40,56-75,83-102,112-117,129-147,154-168,174-191,196-270,280-344,354-377,380-429,431-450,458-483,502-520,525-532,595-602,662-669,675-686,696-702,704-711,720-735,739-748,750-756,770-779,793-800,813-822,834-862 | D:12 | aa 196-218 | D:n.d. | 305,333 |
ORF0836 | 细胞分裂蛋白 | 34-91,100-119,126-143,147-185,187-197,319-335,349-355,363-395,397-412,414-422,424-440,458-465,467-475,480-505,507-529,531-542,548-553,577-589,614-632,640-649,685-704,730-741,744-751,780-786 | D:5 | aa 26-56 | D:n.d. | 306,334 |
ORF1318 | 氨基酸透性酶 | 11-21,25-32,34-54,81-88,93-99,105-117,122-145,148-174,187-193,203-218,226-260,265-298,306-318,325-381,393-399,402-421,426-448 | D:8 | aa 127-152 | D:n.d. | 307,335 |
ORF1321 | 丙酮酸激酶 | 4-11,50-67,89-95,103-109,112-135,139-147,158-170,185-204,213-219,229-242,248-277,294-300,316-323,330-335,339-379,390-402,408-422,431-439,446-457,469-474,484-500,506-513,517-530,538-546,548-561 | E:6 | aa 420-432 | E:GSBZE16(420-432):5/41 | 197,216 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORF1388 | LPXTG细胞壁锚定基元 | 11-31,86-91,103-111,175-182,205-212,218-226,242-247,260-269,279-288,304-313,329-334,355-360,378-387,390-399,407-435,468-486,510-516,535-547,574-581,604-615,635-646,653-659,689-696,730-737,802-812,879-891,893-906,922-931,954-964,997-1009,1031-1042,1089-1096,1107-1120,1123-1230,1149-1162,1176-1184,1192-1207,12091215,1253-1259,1265-1245,12821295,1304-1310,1345-1361,1382-1388,1394-1400,1412-1430,1457-1462,1489-1507,1509-1515,1535-1540,1571-1591,1619-1626,1635-1641,1647-1655,1695-1701,1726-1748,1750-1757,1767-1783,1802-1807,1809-1822,1844-1875,1883-1889,1922-1929,1931-1936,1951-1967,1978-1989,1999-2008,2023-2042,2056-2083,2101-2136,2161-2177 | D:3 | aa 508-523 | D:n.d. | 308,336 |
ORF1402 | 3,4二羟基-2-丙酮-4-磷酸合成酶 | 18-23,32-37,54-63,65-74,83-92,107-114,123-139,144-155,157-164,191-198,232-240,247-272,284-290,295-301,303-309,311-321,328-341,367-376 | E:3 | aa 121-137 | E:GSBZB68(121-137):7/41 | 198,217 |
ORF1473 | 溶血素II(LnkD-白细胞毒素) | 4-36,39-47,5765,75-82,108-114,119-126,135-143,189-195,234-244,250-257,266-272,311-316 | F:1 | aa 255-256 | F:SALAP76(245-256):6/41 | 199,218 |
ORF1523 | 铁摄取调节子 | 13-27,29-55,46-66,68-81,97-116138-145 | D:3 | aa 120-135 | D:n.d. | 309,337 |
ORF1707 | 内膜蛋白60kDa | 4-23,57-77,89-103,119-125,132-172,179-197,210-254,256-265,281-287 | F:1 | aa 104-118 | F:SALBC82(104-118):7/41 | 200,219 |
ORF1754 | amiB | 5-10,16-24,62-69,77-96,100-115,117-126,137-156,165-183,202-211,215-225,229-241,250-260,267-273,290-300,302-308,320-333,336-342,348-356,375-382,384-389 | D:3 | aa 293-312 | D:n.d. | 310,338 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORF1783 | Mrp蛋白(frntB) | 5-29,46-52,70-76,81-87,155-170,192-197,206-213,215-220,225-231,249-258,273-279,281-287,300-306,313-319,323-332,335-341,344-351,360-382,407-431,443-448,459-468,475-496,513-520,522-537,543-550,556-565,567-573,580-585,593-615,619-631,633-642,670-686,688-698,759-766,768-782,799-808,842-848,868-877,879-917,945-950,979-988,996-1002,1025-1036,1065-1084,1101-1107,1113-1119,1125-1142,1163-1169,1183-1189,1213-1219,1289-1301,1307-1315,1331-1342,1369-1378,1385-1391,1410-1419,1421-1427,1433-1447,1468-1475,1487-1494,1518-1529,1564-1570,1592-1609,1675-1681,1686-1693,1714-1725,1740-1747,1767-1774,1793-1807,1824-1841,1920-1937,1953-1958,1972-1978,1980-1986,1997-2011,2048-2066,2161-2166,2219-2224,2252-2257,2292-2298,2375-2380,2394-2399,2435-2440,2449-2468 | F:2 | aa 850-860 | F:SALAQ36(850-860):8/41 | 201,220 |
ORF1848 | Map-ND2C蛋白 | 4-27,42-66,70-76,102-107,113-118,133-38 | E:5 | aa 75-90 | E:GSBZB15(75-90):6/41 | 202,221 |
ORF1891 | 核糖体蛋白L2(rplB) | 31-39,48-54,61-67,75-83,90-98,103-119,123-145,160-167,169-176,182-193,195-206,267-273 | F:4 | aa 239-257 | F:SALAV36(239-257):19/41 | 203,222 |
ORF2011 | 推定的药物转运子 | 5-27,79-85,105-110,138-165,183-202,204-225,233-259,272-292,298-320,327-336,338-345,363-376,383-398,400-422,425-470,489-495,506-518,536-544,549-554,562-568,584-598,603-623 | D:5 | aa 205-224 | D:n.d. | 311,339 |
ORF2027 | 推定的乳糖酶透性酶 | 10-33,38-71,73-103,113-125,132-147,154-163,170-216,222-248,250-269,271-278,287-335,337-355,360-374,384-480,425-442453-465,468-476,478-501,508-529 | E:2 | aa 422-436 | E:GSBZF58(422-436):6/41 | 204,223 |
ORF2087 | 溶血素II(推定的) | 8-27,52-59,73-80,90-99,104-110,117-124,131-140,189-209,217-232,265-279,287-293,299-306 | D:3 | aa 126-147 | D:n.d. | 312,340 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORF2090 | preLukS | 8-26,75-82,118-126,136-142,163-177,182-189,205-215,221-236,239-248,268-274 | F:2 | aa 270-284 | F:SALAQ77(270-2844):23/41 | 205,224 |
ORF2092 | 溶血素II(prelUK-F) | 5-22,30-47,58-65,75-81,87-92,99-105,107-113,119-126,189-195,217-223,234-244,250-257,266-272 | F:3 | aa 238-253 | F:SALAQ67(237-252):10/41 | 206,225 |
ORF2107 | 推定的多种药物抗性蛋白 | 10-28,30-43,50-75,80-113,116-125,136-167,170-191,197-245,253-329,345-367,375-396 | D:9 | aa 54-104 | D:n.d. | 313,341 |
ORF2192 | GntR家族转录调节子,推定的 | 20-31,45-52,55-469,74-79,89-97,108-113,120-128,141-171,188-214 | D:3 | aa 15-35 | D:n.d. | 314,342 |
ORF2305 | 氨基酸透性酶 | 25-79,91-103,105-127,132-149,158-175,185-221,231-249,267-293,307-329,336-343,346-359,363-405,415-442,446-468 | D:53 | aa 363-393 | D:n.d. | 315,343 |
ORF2324 | 柠檬酸转运酶 | 10-77,85-96,99-109,111-138,144-155,167-176,178-205,225-238,241-247,258-280,282-294,304-309,313-327,333-383,386-402,405-422,429-453 | D:7 | aa 37-83 | D:n.d. | 316,344 |
ORF2422 | 阴离子转运子家族蛋白 | 7-26,28-34,36-53,55-73,75-81,87-100,108-117,121-138,150-160,175-181,184-195,202-215,221-247,265-271,274-314,324-337,341-412,414-423,425-440,447-462,464-469 | D:16 | aa 275-295 | D:n.d. | 317,345 |
ORF2553 | SirA | 5-22,54-78,97-103,113-123,130-148,166-171,173-180,192-201,254-261,266-272,310-322 | D:3 | aa 1-22 | D:n.d. | 318,346 |
ORF2555 | 鸟氨酸环化脱氨酶 | 20-35,37-50,96-102,109-120,123-137,141-150,165-182,206-224,237-256,267-273,277-291,300-305,313-324 | E:2 | aa 32-48 | E:GSBZB37(32-48):11/41 | 207,226 |
ORF2558 | 推定的,多种药物抗性流入蛋白 | 11-63,79-129,136-191,209-231,237-250,254-276,282-306,311-345,352-373,376-397 | D:8 | aa 84-100 | D:n.d. | 319,347 |
ORF261O | Cmp5M | 4-30,34-40,79-85,89-98,104-118,124-139,148-160,167-178 | D:13 | aa 114-141 | D:n.d. | 320,348 |
ORF2613 | 乙酰葡萄糖氨2-差向异构酶 | 4-9,17-24,32-38,44-54,68-82,89-95,101-120,124-131,136-142,145-157,174-181,184-191,196-204,215-224,228-236,243-250,259-266,274-281,293-301,314-319,325-331,355-367,373-378 | B:3,F:11 | aa 321-341 | F:SALAU27(325-337):9/41 | 208,227 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORF2628 | 假定的蛋白 | 9-15,28-36,44-62,69-88,98-104,111-136,139-149,177-186,195-217,224-236,241-257,260-278,283-290,292-373,395-408,411-443,465-472,475-496,503-520,552-559,569-589,593-599,607-613,615-636,648-654,659-687,689-696,721-733,738-759,783-789,795-801,811-823,827-836,839-851,867-875,877-883,890-898,900-908,912-931,937-951,961-992,994-1002,1005-1011,1016-1060,1062-1074,1088-1096,1101-1123,1137-1153,1169-1192,1210-1220,1228-1239,1242-1251,1268-1275,1299-1311,1322-1330,1338-1361,1378-1384,1393-1412,1419-1425,1439-1459,1469-1482,1489-1495,1502-1519,1527-1544,1548-1555,1600-1607,1609-1617,1624-1657,1667-1691,1705-1723,1727-1742,1749-1770,1773-1787,1804-1813,1829-1837,1846-1852,18 -1864,1869-1879,1881-1896,1900-1909,1922-1927,1929-1935,1942-1962,1972-2005,2009-2029,2031-2038,2055-2076,2101-2114,2117-2124,2147-2178,2188-2202,2209-2217,2224-2230,2255-2266,2271-2280,2282-2302,2307-2316,2319-2324,2379-2387 | F:6 | aa 694-708aa 790-800aa 1288-1305 | F:SALBD82(1288-1303):9/41 | 209,228 |
ORF2644 | PTS系统,蔗糖特异的HBC成分 | 8-15,24-30,49-68,80-93,102-107,126-147,149-168,170-180,185-193,241-305,307-339,346-355,358-372,382-390,392-415,418-425,427-433,435-444,450-472 | F:4 | aa 106-159 | F:SALAW60(106-125):3/41 | 210,229 |
ORF2654 | 寡肽ABC转运子,推定的 | 5-61,72-84,87-99,104-109,124-145,158-170,180-188,190-216,223-264,270-275,296-336,355-372 | D:5 | aa 182-209 | D:n.d. | 321,349 |
ORF2662 | 麦芽糖ABC转运子,推定的 | 4-21,71-79,99-105,110-121,143-161,199-205,219-235,244-258,265-270,285-291,300-308,310-318,322-328,346-351,355-361,409-416 | F:1 | aa 306-323 | F:SALBC05(306-323):2/41 | 211,230 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORF2710 | 山梨醇脱氢酶 | 4-12,19-40,61-111,117-138,140-153,161-180,182-207,226-235,237-249,253-264,267-274,277-292,311-323 | B:2,F:4 | aa244-257 | F:SALAX93(249-256):6/41 | 212,231 |
ORF2742 | 假定的蛋白 | 4-41,49-56,61-67,75-82,88-104,114-125,129-145,151-165,171-178,187-221,224-230,238-250,252-275,277-304,306-385 | D:188,H:4 | aa303-323 | D:n.d. | 322,350 |
ORF2780 | brnQ | 4-29,41-63,74-95,97-103,107-189,193-209,220-248,260-270,273-299,301-326,328-355,366-397,399-428 | D:3 | aa26-40 | D:n.d. | 323,351 |
ORF2806 | 吞噬相关蛋白 | 10-17,23-29,31-37,54-59,74-81102-115,127-137,145-152,158-165,178-186,188-196,203-210,1-227,232-237 | F:3 | aa104-116 | F:SALBC34:1/1 | 213,232 |
ORF2900 | 保守的假定蛋白 | 4-27,34-43,62-73,81-90,103-116,125-136,180-205,213-218,227-235,238-243,251-259,261-269,275-280,284-294,297-308,312-342,355-380,394-408,433-458,470-510,514-536,542-567 | D:24 | aa360-376 | D:n.d. | 324,352 |
ORF2931 | 保守的假定蛋白 | 4-19,43-54,56-62,84-90,96-102,127-135,157-164,181-187 | E:6 | aa22-37 | E:GSBZA13(22-37):7/41 | 214,233 |
ORF2958 | 外毒素2 | 7-19,26-39,44-53,58-69,82-88,91-107,129-141,149-155,165-178,188-194 | F:1 | aa154-168 | F:SALBB59(154-168):4/41 | 215,234 |
ORF2970 | 推定的表面蛋白 | 9-23,38-43,56-60,69-78,93-101,103-112,132-148,187-193,201-208,216-229,300-312,327-352,364-369,374-383,390-396,402-410,419-426,463-475,482-491 | H:5 | aa1-70 | H:GSBYU66:n.d. | 399,400 |
表2c:通过细菌表面和核糖体展示鉴定的免疫原性蛋白:表皮葡萄球菌
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq.IDno:(DNA+Prot) |
ARF0172 | 阳离子转运ATP酶,E2家族 | 4-34,37-43 | D:6 | aa3-32 | D:nd | 497,548 |
ARF0183 | 缩合酶,推定的FabH-相关 | 4-22,24-49 | D:4 | aa1-52 | D:nd | 498,549 |
ARF2455 | NADH脱氢酶,推定的 | 4-29 | D:3 | aa1-22 | D:nd | 499,550 |
CRF0001 | 未知 | 4-14,16-26 | D:3 | aa5-21 | D:nd | 500,551 |
CRB0002 | 未知 | 4-13,15-23,36-62 | D:5 | aa21-70 | D:nd | 501,552 |
CRF0003 | 未知 | 4-12,14-28 | D:3 | aa4-31 | D:nd | 502,553 |
CRF0004 | 未知 | 5-15,35-71,86-94 | D:4 | aa31-72 | D:nd | 503,554 |
CRP0005 | 未知 | 8-26,28-34 | D:3 | aa:9-33 | D:nd | 504,555 |
CRF0006 | 未知 | 4-11,15-28 | D:3 | aa10-22 | D:nd | 505,556 |
CRF0007 | 未知 | 4-19,30-36 | D:3 | aa7-44 | D:nd | 506,557 |
CRF0008 | 未知 | 10-48 | D:4 | aa:9-44 | D:nd | 507,558 |
CRF0009 | 未知 | 41883 | D:3 | aa5-14 | D:nd | 508,559 |
CRF0192 | 推定的蛋白 | 4-23,25-68 | C:4 | aa15-34 | C:GSBBM10(15-34):n.d. | 445,446 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq.IDno:(DNA+Prot) |
CRF0275 | 推定的蛋白 | 4-40,49-65 | B:5 | aa35-68 | B:SELAK28(35-68):n.d. | 447,448 |
CRF0622 | 推定的蛋白 | 4-12,17-57, 62-70,75-84,86-100 | C:4 | aa75-99 | C:GSBBR74(76-99):n.d. | 449,450 |
CRF0879 | 推定的蛋白 | 4-14,38-44 | A:3,B:10 | aa9-40 | B:SELAC39(10-40):n.d. | 451,452 |
CRF1004 | 推定的蛋白 | 4-40 | A:3,B:5 | aa29-65 | B:SELAI63(35-63):n.d. | 453,454 |
CRF2248 | 推定的蛋白 | 4-10,19-40,53-64,74-91 | C:30 | aa74-111 | C:GSBBN64(16-35):n.d. | 455,456 |
CRF2307 | 推定的蛋白 | 4-19,35-41,80-89 | A:19 | aa41-87 | A:SEFAL47(41-87):n.d. | 457,458 |
CRF2309 | 推定的蛋白 | 15-21 | B:6 | aa4-16 | B:SELAL02(4-16):n.d. | 459,460 |
CRF2409 | 推定的蛋白 | 6-25 | B:6 | aa2-24 | B:SELAB48(5-24):n.d. | 461,462 |
ORF0005 | 假定的蛋白 | 13-27,33-67,73-99,114-129,132-158,167-190,193-234,237-267,269-299,316-330,339-351,359-382,384-423 | D:3 | aa105-128 | D:nd | 509,560 |
ORF0008 | 链球菌血凝集素 | 9-14,16-24,26-32,41-50,71-79,90-96,177-184,232-237,271-278,293-301,322-330,332-339,349-354,375-386,390-396,403-409,453-459,466-472,478-486,504-509,518-525,530-541,546-552,573-586,595-600,603-622,643-660,668-673,675-681,691-697,699-711,713-726,732-749,753-759,798-807,814-826,831-841,846-852,871-878,897-904,921-930,997-1003,1026-1031,1033-1039,1050-1057,1069-1075,1097-1103,1105-1111,1134-1139,1141-1147,1168-1175,1177-1183,1205-1211,1213-1219,1231-1237,1241-1247,1267-1273,1304-1309,1311-1317,1329-1335,1339-1345,1347-1353,1382-1389,1401-1407,1411-1417,1447-1453,1455-1461,1483-1489,1491-1497,1527-1533,1545-1551,1556-1561,1581-1587,1591-1597,1627-1638,1661-1667,1684-1689,1691-1697,1708-1715,1719-1725,1765-1771,1813-1820,1823-1830,1835-1856 | B:2 | aa895-926 | B:SELAF79(895-926):7/12 | 239,268 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORF0038 | 细胞外弹性蛋白前体 | 6-25,29-35,39-45,67-71,82-88,96-102,107-113,119-131,170-176,186-192,196-202,215-220,243-248,302-312,345-360,362-371,378-384,458-470,478-489,495-504 | C:6 | aa136-165 | C:GSBBN08(136-165):1/1 | 353,359 |
ORF0099 | 假定的蛋白 | 6-18,31-17,42-49,51-67,73-85,87-93,102-109,119-126,150-157,170-179,185-191,204-214,217-223,237-248,269-275,278-316320-340,359-365 | D:5 | aa218-265 | D:nd | 510,561 |
ORF0101 | 假定的蛋白 | 4-10,15-27,67-94,123-129,167-173,179-184,187-198,217-222,229-235,238-246 | D:18 | aa26-109 | D:nd | 511,562 |
ORF0121 | C4-二羧酸转运子,厌氧,推定的 | 4-20,24-26,73-86,89-106,110-122,131-164,169-193,204-213,219-236,252-259,263-281,296-306,318-324,328-352,356-397,410-429 | D:5 | aa323-379 | D:nd | 512,563 |
ORF0143 | 氨基酸透性酶 | 25-79,91-103,105-127,132-150157-174,186-206,208-219,231-249,267-294,310-329,336-343,346-405,417-468 | D:35 | aa247-339 | D:nd | 513,564 |
ORF0162 | 免疫显性抗原A | 4-27,35-45,52-68,83-89,113-119,133-150,158-166,171-176,198-204,219-230 | A:11,B:11;C:153 | aa90-227 | B:SELAA19(100-118):1/1B:SELAE24(170-190):11/12 | 240,269 |
ORF0201 | 推定的capa蛋白 | 10-17,27-53,81-86,98-105,126-135,170-176,182-188,203-217,223-232,246-252,254-269,274-280,308-314 | D:9 | aa11-53 | D:nd | 514,565 |
ORF0207 | (rbsK)核糖激酶 | 5-11,15-23,47-55,82-90,98-103,108-114,126-132,134-156,161-186,191-197,210-224,228-235,239-248,258-264,275-290 | B:10 | aa20-45 | B:SELAQ30(20-45):12/12 | 241,270 |
ORF0288 | LrgB | 7-28,34-56,68-119,127-146,149-180,182-189,193-200,211-230 | D:4 | aa112-149 | D:nd | 515,566 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORF0304 | 疱疹病毒saimiri ORF73同源物推定的 | 8-16,30-36,83-106,116-122,135-143,152-165,177-188,216-225 | D:8 | aa69-117 | D:nd | 516,567 |
ORF0340 | 硝酸转运子 | 7-21,24-93,101-124,126-139,141-156,163-179,187-199,202-242,244-261,267-308,313-322,340-353,355-376 | D:5 | aa238-309 | D:nd | 517,595 |
ORF0346 | 假定的蛋白 | 8-27,65-73,87-93,95-105 | D:8 | aa1-29 | D:nd | 518,568 |
ORF0355 | 保守的假定蛋白 | 5-30,37-43,57-66,85-94,103-111,118-125 | C:5 | aa63-86 | C:GSBBL39(63-86):1/1 | 354,360 |
ORF0356 | 保守的假定蛋白 | 4-14,21-53,60-146,161-173,175-182,190-198,200-211 | D:5 | aa51-91 | D:nd | 519,569 |
ORF0406 | 假定的蛋白 | 12-32,35-63,68-102,106-137,139-145,154-168,173-185,203-222,230-259,357-364,366-374 | D:19 | aa1-48,aa69-102 | D:nd | 520,570 |
ORF0425 | 氨基酸透性酶 | 40-58,75-86,93-110,117-144,150-173,199-219,229-260,264-300,317-323,329-356,360-374,377-390,392-398,408-424,427-452 | D:3 | aa401-440 | D:nd | 521,571 |
ORF0442 | SceB前体 | 7-22,42-48,55-66,83-90,109-118,136-141 | C:38 | aa60-102 | C:GSBBM60(65-84):1/1 | 355,361 |
ORF0448 | SsaA前体 | 6-25,39-47,120-125,127-135,140-148,157-168,200-208,210-220,236-243,245-254 | C:170 | aa15-208 | C:GSBBN58(81-105):1/1C:GSBBL13(167-184):1/1C:GSBBL25(22-45):1/1 | 356,362 |
ORF0503 | 核糖体蛋白L2 | 31-39,48-54,61-67,75-83,90-98,103-115,123-145,160-167,169-176,182-193,195-206,267-273 | A:1,B:3 | aa212-273 | B:SELAA47(238-259):12/12 | 242,271 |
ORF0551 | 保守的假定蛋白 | 5-25,29-36,45-53,62-67,73-82,84-91,99-105,121-142,161-177,187-193,203-224,242-251,266-271,278-285 | A:16,B:9 | aa162-213 | B:SELAL12(164-197):8/12 | 243,272 |
ORF0556 | 假定蛋白 | 4-24,30-41,43-68,82-90,107-114123-143,155-168 | D:3 | aa1-26 | D:nd | 522,596 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORH0623 | 摸索,推定 | 10-17,32-38,55-72,77-84,88-96,126-134,152-160,176-185,190-203,208-214,217-225,233-252,257-262 | A:10,B:12;C:1 | aa95-150 | B:SELAB86(95-128):3/12 | 244,273 |
ORF0740 | 假定的蛋白 | 18-24,47-61,69-83,90-96,125-132,140-163,171-188,222-249,281-296,305-315,322-330,335-351,354-368,390-397,411-422,424-431,451-469,479-485,501-507,517-524,539-550,560-568,588-599,619-627,662-673,678-689,735-742,744-749,780-786,797-814,821-827,839-847,857-863,866-876,902-911,919-924,967-982,1005-1015,1020-10261062-1070,1078-1090,1125-1131,1145-1115,1164-1182,1208-1213,1215-1234,1239-1251,1256-1270,1298-1303,1316-1325,1339-1349,1362-1369,1373-1384,1418-1427,1440-1448,1468-1475,1523-1532,1536-1542,1566-1573,1575-1593,1603-1619,1626-1636,1657-1667,1679-1687,1692-1703,1711-17181740-1746,1749-1757,1760-1769,1815-1849,1884-1890,1905-19141919-1925,1937-1947,1955-1963,1970-1978,2003-2032,2075-2089,2117-2124,2133-2140,2146-2151,2161-2167,2173-2179,2184-2196,2204-2220,2244-2254,2259-2264,2285-2296,2300-2318,2328-2334,2347-2354,2381-2388,2396-2408,2419-2446,2481-2486,2493-2500,2506-2516,2533-2540,2555-2567,2576-2592,2599-2606,2615-2639,2647-2655 | B:3 | aa1093-1114 | B:SELAB23(1097-1114):7/12 | 245,274 |
ORF0757 | 假定的蛋白 | 13-20,22-28,33-40,60-76,79-86,90-102,112-122,129-147,157-170,178-185,188-193,200-205,218-228,234-240,243-250,265-273,285-291,310-316,330-348,361-380,399-405,427-446,453-464 | C:6 | aa260-284 | C:GSBBN01(260-284):1/1 | 357,363 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每OEF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORF0912 | DNA错配修复蛋白 | 9-16,28-39,47-56,69-76,104-121,124-130,137-144,185-195,199-214,238-243,293-307,317-337,351-370,385-390,411-428,472-488,498-516,518-525,528-535,538-545,553-559,563-568,579-588,592-607,615-622,632-638,641-648,658-674,676-705,709-720,727-739,742-750,753-760,768-773,783-788,811-819,827-838 | A:25 | aa242-304 | SEFAT31(242-290):n.d. | 441,442 |
ORF0923 | GTP-结合蛋白 | 4-10,18-27,42-55,64-72,77-92,114-126,132-157,186-196,206-217,236-243,257-280,287-300,306-312,321-328,338-351,360-367,371-382,385-399 | B:13 | aa144-163 | B:SELAD55(151-163):8/12 | 246,275 |
ORF0979 | 保守的假定蛋白 | 4-28,44-51,53-84,88-107,113-192 | A:9,B:18 | aa12-51 | B:SELAB01(26-49):5/12 | 247,276 |
ORF0982 | 纳/丙氨酸共转运子(alsT) | 13-21,24-50,73-84,91-118,126-133,142-149,156-175,189-249,251-273,294-332,339-347,358-381,393-413,425-448,458-463 | D:3 | aa227-305 | D:nd | 523,572 |
ORF1230 | 信号肽酶I | 6-33,44-59,61-69,74-82,92-98,133-146,163-175 | D:14 | aa1-53 | D:nd | 524,573 |
ORF1232 | 外切核酸酶RexA | 4-12,16-32,36-48,50-65,97-127,136-142,144-165,176-190,196-202,211-222,231-238,245-251,268-274,280-286,305-316,334-356,368-376,395-402,410-417,426-440,443-449,474-486,499-508,510-525,540-549,568-576,608-617,624-639,646-661,672-678,688-703,706-717,727-734,743-755,767-773,783-797,806-814,830-839,853-859,863-871,877-895,899-918,935-948,976-990,998-1007,1020-1030,1050-1062,1070-1077,1111-1125,1137-1149,1153-1160,1195-1211 | B:6 | aa188-219 | B:SELAA13(188-216):n.d. | 443,444 |
ORF1284 | 透性酶PerM,推定的 | 10-60,72-96,103-109,127-133,146-177,182-189,196-271,277-289,301-319,323-344,347-354 | D:27 | aa55-106 | D:nd | 525,574 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORF1319 | 2-含氧戊二酸-脱羧酶(menD) | 9-31,36-45,59-67,71-81,86-94,96-107,111-122,127-140,153-168,180-211,218-224,226-251,256-270,272-289,299-305,310-323,334-341,345-353,358-364,369-379,384-390,396-410,417-423,429-442,454-464,470-477,497-505,540-554 | B:5;C:1 | aa400-413 | B:SELAF54(404-413):11/12 | 248,277 |
ORF1326 | 自溶素AtlE(lytD) | 6-25,40-46,75-81,150-155,200-205,237-243,288-295,297-306,308-320,341-347,356-363,384-391,417-429,440-452,465-473,481-514,540-546,554-560,565-577,585-590,602-609,611-617,625-634,636-643,661-668,676-684,718-724,734-742,747-754,766-773,775-781,785-798,800-807,825-832,840-857,859-879,886-892,917-923,950-956,972-978,987-1002,1028-1035,1049-1065,1071-1099,1111-1124,1150-1172,1185-1190,1196-1207,1234-1241,1261-1271,1276-1281,1311-1320,1325-1332 | B:7;C:5 | aa1282-1298 | B:SELAD20(1282-1298):10/12 | 249,278 |
ORF1333 | 对苯二酚氧化酶多肽 iv(cc1.9.3.-)(对苯二酚氧化酶亚基qoxd) | 4-27,33-55,66-88 | D:4 | aa3-93 | D:nd | 526,575 |
ORF1356 | 假定的蛋白 | 9-36,44-67,74-97,99-149,161-181,189-198,211-224,245-253,267-273,285-290,303-324,342-394,396-427 | D:32 | aa54-95 | D:nd | 527,597 |
ORF1373 | 二氢硫辛酰氨乙酰转移酶 | 33-39,42-78,103-109,126-136,184-191,225-232,258-279,287-294,306-315,329-334,362-379,381-404,425-430 | A:3,B:1 | aa124-188 | A:SEFAP57(124-188):2/12 | 250,279 |
ORF1381 | 假定的蛋白 | 21-45,62-67,74-106,108-142,154-160,230-236,245-251,298-305 | D:5 | aa7-44 | D:nd | 528,576 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORF1420 | Muts2蛋白,推定的 | 8-32,34-41,46-55,70-76,81-89,97-115,140-148,153-159,165-171,175-188,207-239,256-276,280-289,297-319,321-335,341-347,352-360,364-371,384-411,420-440,449-460,495-502,505-516,560-566,573-588,598-605,607-614,616-624,674-694,702-717 | B:7 | aa581-608 | B:SELAM40(581-604):9/12 | 251,280 |
ORF1443 | 细胞分裂蛋白(divIB) | 61-66,111-117,148-155,173-182,194-224,263-293,297-303,313-321,334-343,345-356,375-381,384-395,408-429,448-454 | D:4 | aa175-229 | D:nd | 529,577 |
ORF1500 | 细胞分裂蛋白FtsY | 100-107,154-167,182-193,200-206,223-231,233-243,249-257,265-273,298-310,326-336,343-362,370-384 | A:2,B:3 | aa77-182 | B:SELAP37(139-162):9/12 | 252,281 |
ORF1665 | 氨基酸ABC转运子,透性酶蛋白 | 4-25,44-55,66-76,82-90,93-99,104-109,176-209,227-242,276-283,287-328,331-345,347-376,400-407,409-416,418-438,441-474 | D:5 | aa1-52 | D:nd | 530,578 |
ORF1707 | 推定的宿主细胞表面外露脂蛋白 | 12-31,40-69,129-137,140-151,163-171,195-202,213-218 | D:4 | aa20-76 | D:nd | 531,598 |
ORF1786 | D-3-磷酸甘油酯脱氢酶推定的蛋白 | 4-10,16-32,45-55,66-78,87-95,103-115,118-124,135-150,154-161,166-174,182-193,197-207,225-231,252-261,266-304,310-315,339-347,351-359,387-402,411-423,429-436,439-450,454-464,498-505,508-515 | D:5 | aa400-442 | D:nd | 532,579 |
ORF1849 | yhjN 蛋白 | 8-51,53-69,73-79,85-132,139-146,148-167,179-205,212-224,231-257,264-293,298-304,309-317,322-351 | D:5 | aa254-301 | D:nd | 533,580 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORF1877 | 蛋白-外运膜蛋白SecD(secD-1) | 6-19,26-39,41-51,59-67,72-85,91-98,104-111,120-126,147-153,158-164,171-178,199-209,211-218,233-249,251-257,269-329,362-368,370-385,392-420,424-432,454-489,506-523,534-539,550-556,563-573,576-596,603-642,644-651,655-666,685-704,706-733,747-753 | D:7 | aa367-409 | D:nd | 534,581 |
ORF1912 | 未知的保守蛋白(conserved) | 23-35,37-70,75-84,90-112,129-135,137-151,155-180,183-209,211-217,219-225,230-248,250-269,274-284,289-320,325-353,357-371,374-380,384-399,401-411, | D:4 | aa131-187 | D:nd | 535,582 |
ORF2015 | 海藻糖-6-磷酸水解酶 | 8-17,30-54,82-89,94-103,157-166,178-183,196-204,212-219,222-227,282-289,297-307,345-364,380-393,399-405,434-439,443-449,453-475,486-492,498-507,512-535,538-548 | A:3,B:8 | aa465-498 | B:SELAH62(465-498):5/12 | 253,282 |
ORF2018 | 葡萄糖-6-磷酸1-DH | 4-16,21-27,39-51,60-69,76-83,97-118,126-132,159-167,171-177,192-204,226-240,247-259,281-286,294-305,314-320,330-338,353-361,367-372,382-392,401-413,427-434,441-447,457-463 | B:17 | aa250-287 | B:SELA119(250-279):3/12 | 254,283 |
ORF2040 | LysM结构域蛋白蛋白 | 51-56,98-108,128-135,138-144,152-158,177-192,217-222,232-251,283-305,406-431,433-439 | D:23 | aa259-331 | D:nd | 536,583 |
ORF2098 | PilB重复蛋白 | 13-18,36-43,45-50,73-79,95-100111-126,133-139 | A:60 | aa1-57 | A:SEFAQ50(15-57):5/12 | 255,284 |
ORF2139 | 钠/硫酸盐共转运在家族蛋白,推定的 | 7-12,22-97,105-112,121-128,130-146,152-164,169-189,192-203,211-230,238-246,260-281,304-309,313-325,327-357,367-386,398-444,447-476,491-512 | D:41 | aa42-118 | D:nd | 537,584 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORF2172 | SceB前体(lytE) | 4-23,28-34,38-43,45-51,63-71,85-96,98-112,118-126,167-174,179-185,219-228,234-239,256-263 | A:438,B:40,D:4 | aa6-215 | B:SELAH53(188-209):3/12 | 256,285 |
ORF2200 | 锌ABC转运子,透性酶蛋白,推定的 | 4-31,33-40,48-64,66-82,92-114,118-133,137-159,173-246,248-266 | D:19 | aa162-225 | D:nd | 538,585 |
ORF2248 | 膜蛋白,MmpL家族推定的 | 4-11,17-34,72-78,127-137,178-227,229-255,262-334,352-380,397-405,413-419,447-454,462-467,478-490,503-509,517-558,560-568,571-576,285-609,623-629,631-654,659-710,741-746,762-767,771-777,788-793,856-867 | D:17 | aa1-59,aa159-225,aa634-674 | D:nd | 539,586 |
ORF2260 | 在其他中的未知保守蛋白 | 5-10,18-29,31-37,66-178,196-204,206-213 | B:4 | aa123-142 | B:SELAG77(123-142):12/12 | 257,286 |
ORF2282 | 保守假定蛋白 | 16-22,41-50,52-64,66-74,89-95,107-114,123-130,135-159,167-181,193-199,223-231,249-264,279-289 | A:4 | aa51-97 | A:SEFAR88(51-97):3/12 | 258,287 |
ORF2376 | DivIC推定的,同源物 | 27-56,102-107,111-116 | D:7 | aa15-58 | D:nd | 540,587 |
ORF2439 | 膜结合 nd细胞溶解酶的胞壁质转糖苷酶D,推定的保守的假定蛋白 | 4-9,11-26,36-56,59-73,83-100,116-130,148-163,179-193,264-270,277-287,311-321 | A:459,B:2,D:53 | aa10-217 | B:SELAC31(75-129):12/12 | 259,288 |
ORF2493 | 4-29,37-77,80-119 | D:6 | aa69-113 | D:nd | 541,588 | |
ORF2535 | ATP-结合盒推定的转运子样蛋白 | 5-28,71-81,101-107,128-135,146-52,178-188,209-214,224-233,279-294,300-306,318-325,342-347,351-357 | D:8 | aa1-65 | D:nd | 542,589 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORF2627 | 阳离子转运ATP酶,E1-E2家族,推定的 | 8-31,34-80,125-132,143-153,159-165,176-189,193-198,200-206,215-242,244-262,264-273,281-289,292-304,318-325,327-338,347-371,404-416,422-429,432-450,480-488,503-508,517-525,539-544,551-562,574-587,600-631,645-670 | D:3 | aa61-105 | D:nd | 543,590 |
ORF2635 | 假定蛋白 | 4-10,17-24,26-42,61-71,90-96102-111,117-125,158-164,173-182,193-201,241-255,268-283,289-298,305-319,340-353,360-376,384-390,394-406 | A:2,B:2 | aa139-169 | B:SELAB63(138-163):7/12 | 260,289 |
ORF2669 | 假定蛋白 | 4-21,35-42,85-90,99-105,120-125,148-155,175-185,190-196,205-210,217-225 | A:14,B:8 | aa22-81 | B:SELAE27(22-51):5/12 | 261,290 |
ORF2671 | 假定蛋白 | 4-23,43-49,73-84,93-98,107-113,156-163,179-190,197-204,208-218,225-231,248-255 | A:44,B:14 | aa23-68 | B:SELAD21(36-61):5/12 | 262,291 |
ORF2673 | 假定蛋白 | 4-20,65-71,99-105,148-155,171-182,190-196,204-210,221-228,240-246 | A:16,B:3 | aa23-68 | B:SELAE25(23-54):2/12 | 263,292 |
ORF2694 | 假定蛋白 | 4-26,93-98,121-132,156-163,179-192,198-204,212-220,225-238 | A:19,B:30 | aa25-82 | B:SELAB26(27-60):5/12 | 264,293 |
ORF2695 | 假定蛋白 | 4-26,43-50,93-98,107-113,156-163,179-190,198-204,212-218,225-231,247-254 | A:7 | aa22-78 | A:SEFAH77(22-66):6/12 | 265,294 |
ORF2719 | 2成分传感器组氨酸激酶,推定的 | 5-52,60-71,75-84,91-100,127-135,141-156,163-177,185-193,201-214,222-243,256-262,270-279,287-293,298-303,321-328,334-384,390-404,411-418,427-435,438-448,453-479,481-498,503-509 | B:4 | aa123-132 | B:SELAA62(123-132):6/12 | 266,295 |
ORF2728 | 堆积相关蛋白 | 4-13,36-44,76-86,122-141,164-172,204-214,235-242,250-269,291-299,331-337,362-369,377-396,419-427,459-469,505-524,547-555,597-597,618-625,633-652,675-683,715-727,740-753,761-780,803-811,842-853,962-968,1006-1020 | A:265,B:448;C:4,D:9 | aa803-1001 | B:SELAA10(850-878):11/12 | 267,296 |
金黄色葡萄球菌抗原性蛋白 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | Seq IDno:(DNA+Prot) |
ORF2740 | 脂肪酶前体 | 4-21,190-200,218-228,233-241,243-261,276-297,303-312,316-325,346-352,381-387,436-442,457-462,495-505,518-532,543-557,574-593 | C:3 | aa110-177 | C:GSBBL80(110-177):1/1 | 358,364 |
ORF2764 | 寡肽 ABC转运子,透性酶推定的 | 14-36,62-131,137-147,149-162,164-174,181-207,212-222,248-268,279-285 | D:4 | aa6-41 | D:nd | 544,591 |
ORF2767 | 在其他里的未知保守蛋白 | 7-20,22-35,40-50,52-61,63-92,94-101,103-126,129-155,161-178,192-198,200-208,210-229,232-241,246-273,279-332,338-359,369-383 | D:4 | aa276-316 | D:nd | 545,592 |
ORF2809 | 钠/硫酸共转运子家族蛋白 | 4-29,37-53,56-82,87-100,108-117,121-138,150-160,175-180,189-195,202-214,220-247,269-315,324-337,341-355,361-412,414-423,425-440,447-467 | D:9 | aa266-317,aa357-401 | D:nd | 546,593 |
ORF2851 | 推定的穿膜流出蛋白 | 7-13,20-32,37-90,93-103,107-126,129-155,159-173,178-189,195-221,234-247,249-255,268-303,308-379 | D:11 | aa137-185 | D:nd | 547,594 |
表2d,通过细菌表面和核糖体展示鉴定的免疫原性蛋白:金黄色葡萄球菌(新注解)
金黄色葡萄球菌抗原性蛋白 | 原有ORF序号 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | SeqID no:(DNA+Prot) |
SaA0003 | ORF2967&ORF2963 | repC | 7-19,46-57,85-91,110-117,125-133,140-149,156-163,198-204,236-251,269-275,283-290,318-323,347-363 | B:3,C:14;F:29 | aa9-42aa156-241aa300-314aa343-420 | C:GSBYI53(9-42):1/1C:GSBYG39(156-241):1/1C:GSBYM94(343-420):26/30 | 394,396 |
ORF0123 | ORF1909-18aa在末端 | 未知 | 4-10,25-30,38-57,91-108,110-123,125-144,146-177,179-198,216-224,226-233 | B:3,E:7,G:1 | aa145-163 | B:GSBXF80(150-163):5/27E:GSBZC17(150-163):25/41 | 409,410 |
ORF0160 | ORF1941-16aa在末端 | 未知 | 4-26,34-70,72-82,86-155,160-166,173-205,207-228,230-252,260-268,280-313 | A:1 | aa96-172 | A:GSBXO07(96-172):5/30 | 411,412 |
ORF0657 | ORF un-知 | LPXTGVI蛋白 | 9-33,56-62,75-84,99-105,122-127,163-180,186-192,206-228,233-240,254-262,275-283,289-296,322-330,348-355,416-424,426-438,441-452,484-491,541-549,563-569,578-584,624-641 | A:2,B:27,F:15 | aa526-544 | B:GSBXE07-bdb1(527-542):11/71F:SALAX70(526-544):11/41 | 413,414 |
ORF1050 | ORF1307-4aa在末端 | 未知 | 45-68,72-79,91-101,131-142,144-160,179-201 | A:1,H:45 | aa53-124 | A:GSBXM26(53-124):7/30 | 415,416 |
ORF1344 | ORF0212-10aa在末端 | NifS蛋白同源物 | 13-26,40-49,61-68,92-112,114-123,138-152,154-183,194-200,207-225,229-240,259-265,271-284,289-309,319-324,330-336,346-352,363-372 | A:11 | aa24-84 | A:GSBXK59-bmd21(24-84):6/29 | 417,418 |
金黄色葡萄球菌抗原性蛋白 | 原有ORF序号 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | SeqID no:(DNA+Prot) |
ORF1632 | ORF1163-4aa在末端 | SdrH homolog同源物 | 4-31,50-55,243-257,259-268,298-316,326-335,364-370,378-407 | B:6,E:11,F:34 | aa101-115aa115-139aa158-186 | B:GSBXG53(164-182):39/71F:SALAP07(101-115):11/41 | 419,420 |
ORF2180 | ORF0594-2aa在末端 | LPXTGIV蛋白 | 9-17,24-45,67-73,82-90,100-107,117-134,137-145,158-168,176-183,188-194,206-213,223-231,243-248,263-270,275-282,298-304,344-355,371-377,382-388,427-433,469-479,500-505,534-559,597-607,662-687,790-815,918-943,1032-1037,1046-1060,1104-1112,1128-1137,1179-1184,1197-1204,1209-1214,1221-1239 | A:3,C:3,E:6,F:2,H:6 | aa491-587aa633-715aa702-757#aa758-830(aa830-885)# | A:GSBXS61(491-555):1/1A:GSBXL64(494-585):1/1A:GSBXS92(758-841):1/1A:bmd4(702-757):16/30#(A:bmd4(830-885):16/30)#F:SALBC43(519-533):4/41 | 421,422 |
ORF2184 | ORF0590-8aa在末端 | FnbpB | 10-29,96-116,131-137,146-158,167-173,177-182,185-191,195-201,227-236,260-266,270-284,291-299,301-312,348-356,367-376,382-396,422-432,442-453,480-484,497-503,519-527,543-548,559-565,579-585,591-601,616-623,643-648,657-663,706-718,746-758,791-796,810-817,819-825,833-839,847-853,868-885,887-895,919-932 | A:2,C:4,G:9 | aa694-769aa774-847 | A:GSBXM62(694-769):28/28A:GSBXR22(774-847):1/1 | 423,424 |
ORF2470 | ORF0299-14aa在末端 | 保守的假定蛋白 | 4-27,36-42,49-55,68-73,94-101,131-137,193-200,230-235,270-276,294-302,309-324,334-344,347-364,396-405,431-437,498-508,513-519,526-532,539-544,547-561,587-594,618-630,642-653,687-699,713-719,752-766 | C:3 | aa400-441 | C;GSBYH60(400-441):28/31 | 425,426 |
ORF2498 | 在N末端长580个氨基酸;加上其他变化 | 保守的假定蛋白 | 8-19,21-44,63-76,86-92,281-286,303-322,327-338,344-354,364-373,379-394,405-412,453-460,501-506,512-518,526-542,560-570,577-583,585-604,622-630,645-673,677-691,702-715,727-741,748-753,770-785,789-796,851-858,863-869,876-881,898-913,917-924,979-986,991-997,1004-1009,1026-1041,1045-1052,1107-1114,1119-1125,1132-1137,1154-1169,1173-1192,1198-1204,1240-1254,1267-1274,1290-1298,1612-1627 | D:12,F:6 | aa358-411aa588-606aa895-909 | D:17/21F:SALAT38(895-909):8/41 | 427,428 |
金黄色葡萄球菌抗原性蛋白 | 原有ORF序号 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | SeqID no:(DNA+Prot) |
ORF2548 | ORF2711-12aa在末端 | IgG结合蛋白A | 4-37,44-53,65-71,75-82,105-112,126-132,136-143,164-170,184-190,194-201,222-232,242-248,252-259,280-291,300-317,413-420,452-460,485-503 | A:55,B:54,C:35,F:59,G:56,H:38 | aa1-123aa207-273aa310-410 | A:GSBXK68(1-73):21/30A:GSBXK41(35-123):1/1A:GSBXN38(207-273):19/30A:GSBXL11(310-363):10/30B:GSBXB22(394-406):37/71F:SALAM17(394-406):29/41 | 429,430 |
ORF2746 | ORF2507-3aa在末端 | 与.同源ORF1 | 4-9,12-17,40-46,91-103,106-113,116-125,150-160,172-177,182-188,195-206,241-261,263-270,277-285,287-294 | A:1,H:13 | aa63-126 | A:GSBXO40(66-123):8/29 | 431,432 |
ORF2797 | ORF2470-24aa在末端 | 未知 | 13-32,40-75,82-95,97-112,115-121,125-154,166-192,201-225,227-252,268-273,288-297,308-375,379-434 | B:3,E:2,F:13,H:3 | aa159-176aa325-339 | B:GSBXE85(159-176):11/27F:SALAQ47(159-176):8/41 | 433,434 |
ORF2960 | ORF2298-5aa在末端 | 推定的外毒素 | 8-31,35-44,106-113,129-135,154-159,168-178,203-215,227-236,240-249,257-266,275-281,290-296,298-305,314-319,327-334 | C:101,E:2,H:58 | aa1-80aa48-121aa98-190 | C:GSBYG32(1-80)::6/7C:GSBYG61-bhe2(48-116):26/30C:GSBYN80(98-190):13/17 | 435,436 |
ORF2963 | ORF2295-5aa在末端 | 推定的外毒素 | 8-23,35-41,64-70,81-87,109-115,121-132,150-167,177-188,194-201,208-216,227-233,238-248,265-271,279-285 | C:3,E:3,G:1 | aa17-95 | C:GSBYJ58(17-95):9/15 | 437,438 |
金黄色葡萄球菌抗原性蛋白 | 原有ORF序号 | 推定的功能(以同源性) | 预测的免疫原性氨基酸aa** | 每ORF的所选克隆号和筛选 | 鉴定的免疫原性区域的定位 | 同相关区域的血清反应性(阳性/全部) | SeqID no:(DNA+Prot) |
ORF3200 | ORF1331+8506aaat N-terminus | 推定的细胞外基质结合蛋白 | 8-32,45-52,92-103,154-159,162-168,207-214,232-248,274-280,297-303,343-349,362-375,425-442,477-487,493-498,505-512,522-533,543-550,558-564,568-574,580-600,618-630,647-652,658-672,692-705,711-727,765-771,788-798,812-836,847-858,870-898,903-910,1005-1015,1018-1025,1028-1036,1058-1069,1075-1080,1095-1109,1111-1117,1119-1133,1166-1172,1183-1194,1200-1205,1215-1222,1248-1254,1274-1280,1307-1317,1334-1340,1381-1391,1414-1420,1429-1439,1445-1467,1478-1495,1499-1505,1519-1528,1538-1550,1557-1562,1572-1583,1593-1599,1654-1662,1668-1692,1701-1707,1718-1724,1738-1746,1757-1783,1786-1793,1806-1812,1815-1829,1838-1848,1853-1860,1875-1881,1887-1893,1899-1908,1933-1940,1952-1961,1964-1970,1977-1983,1990-1996,2211-2018,2025-2038,2086-2101,2103-2117,2177-2191,2195-2213,2220-2225,4*2237-2249,2273-2279,2298-2305,2319-2327,2349-2354,2375-2381,2391-2398,2426-2433,2436-2444,2449-2454,2463-2469,2493-2499,2574-2589,2593-2599,2605-2611,2615-2624,2670-2684,2687-2698,2720-2727,2734-2754,2762-2774,2846-2866,2903-2923,2950-2856,2985-2998,3011-3031,3057-3064,2*3102-3117,3137-3143,3186-3195,3211-3219,3255-3270,3290-3300,3327-3334,3337-3343,3390-3396,3412-3419,3439-3446,3465-3470,3492-3500,3504-3510,3565-3573,3642-3650,3691-3698,3766-3775,3777-3788,3822-3828,3837-3847,3859-3864,3868-3879,3895-3902,3943-3951,3963-3971,3991-3997,4018-4030,4054-4060,4074-4099,4123-4129,4147-4153,4195-4201,4250-4255,4262-4267,4270-4277,4303-4310, | A:11,B:11,C:36,H:32 | aa8543-8601aa8461-8475 | A:GSBXL07(8543-8601):6/28 | 439,440 |
4321-4330,4343-4352,4396-4408,4446-4451,4471-4481,4503-4509,4516-4534,4596-4604,4638-4658,4698-4710,4719-4732,4776-4783,4825-4833,4851-4862,4882-4888,4894-4909,4937-4942,5047-5054,5094-5100,5102-5112,5120-5125,5146-5153,5155-5164,5203-5214,5226-5236,5278-5284,5315-5321,5328-5342,5348-5359,5410-5420,5454-5466,5481-5489,5522-5538,5597-5602,5607-5614,0*5623-5629,5650-5665,5707-5719,5734-5742,5772-5778,5785-5790,5833-5845,5857-5863,5899-5904,5908-5921,5959-5971,5981-5989,6010-6017,6034-6043,6058-6064,6112-6120,6154-6169,6210-6217,6231-6240,6261-6268,6288-6294,6318-6324,6340-6349,6358-6369,6402-6407,6433-6438,6483-6493,6513-6519,6527-6546,6561-6574,6599-6608,6610-6616,6662-6673,6696-6705,6729-6743,6769-6775,6792-6801,6819-6828,6840-6846,6860-6870,6915-6928,6966-6972,7021-7028,7032-7047,7096-7101,7109-7117,7138-7149,7157-7162,7201-7206,7238-7253,7283-7294,7296-7302,7344-7365,7367-7376,7389-7404,7413-7433,7475-7482,7493-7500,7535-7549,7596-7608,7646-7651,7661-7678,7722-7731,7741-7754,7764-7769,7776-7782,7791-7806,7825-7837,7862-7875,7891-7897,7922-7931,7974-7981,7999-8005,8039-8045,8049-8065,8070-8075,8099-8112,8119-8125,8151-8158,8169-8181,8226-8232,8258-8264,8291-8299,8301-8310,8325-8335,8375-8389,8394-8400,8405-5412,8421-8436,8478-8485,8512-8521,8528-8538,8564-8579,8587-8594,8603-8615,8626-8637,8640-8646,8657-8672,8684-8691,8725-8736,8748-8761,8777-8783,8794-8799,8810-8825,8851-8862,8874-8887,8903-8912,8914-8926,8933-8943,8954-8960,8979-8988,9004-9011,9035-9041,9056-9069,9077-9086,9088-9096,9106-9111,9124-9133,9183-9191,9224-9231,9235-9241,9250-9265,9279-9290,9295- |
9300,9326-9343,9408-9414,9422-9427,9435-9441,9455-9461,9507-9517,9532-9538,9580-9589,9594-9600,9614-9623,9643-9648,9665-9383,9688-9700,9720-9726,9742-9758,9767-9775,9795-9800,9817-9835,9842-9847,9912-9919,9925-9938,9943-9963,9970-10009,10025-10031,10037-10043,10045-10063,10066-10073,10117-10124,10126-10136,10203-10210,10218-10225,10232-10242,10287-10292,10303-10323,10352-10360,10385-10396,10425-10431,10452-10459,10480-10485 |
表3,使用人血清对金黄色葡萄球菌表面蛋白进行血清学蛋白组分析
a)逆境条件下的金黄色葡萄球菌agr株
点ID/血清 | IC401∶20,000 | IC35,N26,C41∶50,000各 | 婴儿库C2,5,6,10,121∶10,000 | N22 1∶10.000IC40 1∶50,000 |
PCK2 | + | + | - | + |
PCK4 | + | +++ | - | +++ |
PCK5 | - | (+) | - | + |
PCK6 | + | + | - | + |
点ID/血清 | IC35,401∶50,000N22 1∶10,000 | P-库(P6,18,25,28,29)1∶50,000各 | 婴儿库C2,5,6,10,121∶10,000 | |
PAC1 | ++ | ++ | - | |
PAC2 | ++ | +++ | - | |
PAC3 | - | + | - | |
PAC5 | - | ++ | - |
点ID/血清 | P-库(P6,18,25,28,29)1∶50,000各 | 婴儿141∶10,000 | IC库/IgG(N26,IC34,35)1∶30,000各 | IC库/IgA(N26,IC34,35)1∶30,000各 |
PAC11 | ++ | - | ++ | ++ |
PAC12 | ++ | - | ++ | ++ |
PAC13 | - | - | - | ++ |
PAC14 | - | - | + | + |
PAC15 | - | - | +++ | +++ |
PAC16 | + | - | + | + |
PAC17 | + | - | + | + |
PAC18 | ++ | - | - | - |
PAC19 | - | - | ++ | ++ |
PAC20 | ++ | - | - | - |
POV31 | +++ | - | - | - |
POV32 | + | - | - | - |
POV33 | + | - | - | - |
POV34 | + | - | - | - |
POV35 | + | - | - | - |
POV36 | + | - | - | - |
POV37 | ++ | - | - | - |
POV38 | ++ | - | - | - |
POV39 | +++ | - | - | - |
POV40 | +++ | - | - | - |
b)标准条件下的金黄色葡萄球菌COL株
点ID/血清 | IC库(N26,IC34,35)1∶30,000各 | IC351∶20,000 | P181∶10,000 | P251∶10,000 | P11∶5,000 | P291∶2,500 | 婴儿181∶10,000 |
POV2 | +++ | +++ | +++ | +++ | +++ | - | - |
POV3.1 | +++ | +++ | +++ | +++ | +++ | - | - |
POV3.2 | +++ | +++ | +++ | +++ | +++ | - | - |
POV4 | + | +++ | - | - | - | - | - |
POV7 | - | - | +++ | - | - | - | - |
POV10 | - | ++ | (+) | (+) | - | (+) | - |
POV12 | - | - | - | - | - | +++ | - |
POV13 | ++ | +++ | +++ | +++ | ++ | ++ | - |
POV14 | ++ | +++ | +++ | ++ | ++ | ++ | - |
POV15 | + | + | - | + | (+) | - | - |
c)逆境条件下的金黄色葡萄球菌COL株
点ID/血清 | P-库(F6,18,25,28,29)1∶50,000各 | IC34+IC351∶20,000各 | P181∶10,000 | P291∶10,000 | 婴儿141∶10,000 |
POV16 | - | +++ | - | - | - |
POV17 | - | +++ | (+) | - | - |
POV18 | + | - | ++ | - | - |
POV19 | (+) | - | +++ | - | - |
POV21 | - | - | + | - | - |
POV23 | - | + | - | - | - |
POV24 | - | + | - | - | - |
POV25 | + | - | - | - | - |
表4,通过MALDI-TOF-MS测序鉴定的金黄色葡萄球菌抗原(折叠的ORF也通过细菌表面展示鉴定)。对选定的用人血清通过血清学蛋白组所鉴定的抗原的抗原性区域进行预测
点ID | 金黄色葡萄球菌蛋白(ORF no./ab-brev.) | 以同源性推定的功能 | Seq ID no:(DNA,Prot) | 推定的位点 |
PCK2 | ORF0599 | 甘氨酰胺-核糖基合成酶 | 107,108 | 细胞质 |
PCK5 | ORF0484 yitU | 保守的假定蛋白(yitU) | 109,110 | 细胞质 |
PCK6 | ORF2309mqo | 膜结合的苹果酸-醌氧化酶 | 111,112 | 外周膜 |
POV2 | ORF0766 aux1 | 起抗新青霉素I作用的蛋白磷酸酯酶 | 113,114 | 穿膜 |
POV4,17PAC14,19 | ORF0078 EF-Tu | 延长因子Tu类似的44kDa蛋白的C末端部分 | 115,116 | 细胞质/分泌 |
POV51) | ORF0782 | 3-酮酰基-酰基运载蛋白还原酶(fabG) | 117,118 | 细胞质 |
POV7 | ORF0317 SecA | 跨膜蛋白转运SecA | 39,91 | 细胞质 |
POV10 | ORF1252 yrzC | 假定的BACSU11.9kd蛋白(upf0074(rff2)家族) | 119,120 | 细胞质 |
POV12 | ORF0621 pdhB | 二氢硫辛酰氨乙酰转移酶(pdhB) | 121,122 | 细胞质 |
POV14 | ORF0072 rpoB | DNA指导的RNA聚合酶B | 125,126 | 细胞质 |
POV15 | ORF0077 EF-G | 85kD的玻璃粘连蛋白 | 127,128 | 细胞质 |
POV18 | not foundYLY1 | 普通压力蛋白 YLY1 | 129,130 | 细胞质 |
POV301) | ORF0069 RL7 | 核糖体蛋白 L7 | 131,132 | 细胞质 |
POV21 | ORF0103yckG | 可能的己酮糖-6-磷酸合成酶(yckG) | 133,134 | 细胞质 |
,POV24 | ORF0419yurX | 保守的假定蛋白 (yurX) | 137,138 | 细胞质 |
点ID | 金黄色葡萄球菌蛋白(ORF no./ab-brev.) | 以同源性推定的功能 | Seq ID no:(DNA,Prot) | 推定的位点 |
POV25 | ORF2441gidA | 葡萄糖抑制的分裂蛋白A(gidA) | 139,140 | 细胞质 |
PAC1 | ORF1490prsA | 蛋白外运蛋白prsa前体(prsA) | 173,174 | 周质 |
PAC2 | ORF1931ModA | 周质钼酸盐结合蛋白(ModA) | 175,176 | 表面 |
PAC3 | ORF2053 | 重金属依赖的转录激活物,推定的多种药物抗性流出泵pmrA的调节子 | 177,178 | 细胞质 |
PAC5 | ORF2233ydaP | 丙酮酸氧化酶(ydaP) | 179,180 | 细胞质 |
PAC11 | ORF1361 | LPXTGV,细胞外基质-bdg. | 3,56 | 表面 |
PAC12 | ORF1244alaS | 丙氨酸-tRNA合成酶 | 159,160 | 细胞质 |
PAC13 | ORF0835ymfA | RNA加工酶/ATP-bdg | 161,162 | 细胞质 |
PAC15 | ORF1124bfmBB | 支链alpha-酮酸脱氢酶复合体的硫辛酰氨的乙酰转移酶成分 | 163,164 | 细胞质 |
PAC16 | ORF0340GAPDH | 3-磷酸-甘油醛的脱氢酶 | 165,166 | 细胞质 |
PAC17 | not foundContig83 | 5‘-甲基硫代腺苷核苷酶/S-腺苷高半胱氨酸核苷酶 ase | 细胞质 | |
PAC20 | ORF2711 | 与ORF2715有75%同一性,与假定蛋白相似 | 167,168 | 未知 |
POV31 | ORF0659 | 29kDa 表面蛋白 | 236,238 | 表面 |
POV32 | ORF0659 | 29kDa 表面蛋白 | 236,238 | 表面 |
POV33 | ORF0659 | 29kDa 表面蛋白 | 236,238 | 表面 |
POV34 | ORF0659 | 29kDa 表面蛋白 | 236,238 | 表面 |
POV35 | ORF0659 | 29kDa 表面蛋白 | 236,238 | 表面 |
POV36 | ORF00661 | LPXTG-基元细胞壁锚定结构域蛋白 | 235,237 | 表面 |
POV37 | ORF0659 | 29kDa 表面蛋白 | 236,238 | 表面 |
点ID | 金黄色葡萄球菌蛋白(ORF no./ab-brev.) | 以同源性推定的功能 | Seq ID no:(DNA,Prot) | 推定的位点 |
POV38 | ORF0659 | 29kDa 表面蛋白 | 236,238 | 表面 |
POV39 | ORF0657 | LPXTG-锚定的表面蛋白 | 1,142 | 表面 |
POV40 | not identified |
Seq ID no:(蛋白) | 点ID | 金黄色葡萄球菌ORFno./abbrev. | 推定的位点 | 推定的抗原性表面区域(抗原性包装) |
112 | PCK6 | ORF2309mqo | 外周膜 | 61-75,82-87,97-104,113-123,128-133,203-216,224-229,236-246,251-258,271-286,288-294,301-310,316-229,337-346,348-371,394-406,418-435,440-452 |
114 | POV2 | ORF766 aux1 | 穿膜 | 30-37,44-55,83-91,101-118,121-128,136-149,175-183,185-193,206-212,222-229,235-242 |
116 | POV4 | ORF078 EF-Tu | 细胞质/分泌出 | 28-38,76-91,102-109,118-141,146-153,155-161,165-179,186-202,215-221,234-249,262-269,276-282,289-302,306-314,321-326,338-345,360-369,385-391 |
176 | PAC2 | ORF1931ModA | 周质 | 29-44,74-83,105-113,119-125,130-148,155-175,182-190,198-211,238-245 |
174 | PAC1 | ORF1490prsA | 周质 | 5-24,38-44,100-106,118-130,144-154,204-210,218-223,228-243,257-264,266-286,292-299 |
168 | PAC20 | ORF2711 | 未知 | 7-14,21-30,34-50,52-63,65-72,77-84,109-124,129-152,158-163,175-190,193-216,219-234 |
点ID | GI no.或TIGR no. | 金黄色葡萄-球菌(ORF no./ab-brev.) | 推定的功能(以同源性) | Seq ID no:(DNA,Prot) |
PCK2 | TIGR1280 | ORF0599 | 甘氨酰胺-核糖基合成酶 | 107,108 |
PCK4 | 7672993 | ORF2268 IsaA | 可能粘附/聚集 | 12,64 |
PCK5 | TIGR6209 | ORF0484 yitU | 保守的假定蛋白(yitU) | 109,110 |
PCK6 | TIGR6182 | ORF2309 | 膜结合的苹果酸-醌氧化酶 | 111,112 |
POV2 | 6434044 | ORF0766 aux1 | 起抗新青霉素I作用的蛋白磷酸i-酯酶 | 113,114 |
POV3.1 | 7672993 | ORF2268 IsaA | 可能粘附/聚集 | 12,64 |
POV3.2 | 7672993 | ORF2268 IsaA | 可能粘附/聚集 | 12,64 |
POV4 | TIGR8079 | ORF0078 EF-Tu | 延长因子Tu类似的44kDa蛋白的rC末端部分 | 115,116 |
POV51) | TIGR8091 | ORF0782 | 3-酮酰基-酰基运载蛋白还原酶(fabG) | 117,118 |
POV7 | 2500720 | ORF0317 SecA | 跨膜蛋白转运SecA | 39,91 |
POV10 | TIGR8097 | ORF1252 yrzC | 假定的BACSU11.9kd蛋白(upf0074(rff2)家族) | 119,120 |
POV12 | 2499415 | ORF0621 pdhB | 二氢硫辛酰氨乙酰转移酶(pdhB) | 121,122 |
POV13 | 7470965 | ORF0094 SdrD | 纤维蛋白原-bdg.(LPXTG)蛋白同源物(SdrD) | 123,124 |
POV14 | 1350849 | ORF0072 rpoB | DNA指导的RNA聚合酶B | 125,126 |
POV15 | 6920067 | ORF0077 EF-G | 85kD的玻璃粘连蛋白 | 127,128 |
POV17 | TIGR8079 | ORF0078 | 延长因子Tu类似的44kDa蛋白的C末端部分 | 115,116 |
POV18 | 3025223 | not found | 普通压力蛋白YLY1 | 129,130 |
POV301) | 350771 | ORF0069 RL7 | 核糖体蛋白L7 | 131,132 |
POV21 | ORF0103 | 可能的己酮糖-6-磷酸合成酶(yckG) | 133,134 | |
POV23 | ORF0182 | 脂蛋白(表皮葡萄球菌) | 135,136 |
1)用标准条件下生长的金黄色葡萄球菌8325-4 spa-的全溶菌液进行鉴定。血清反应活性用1/1患者和2/4正常血清,但不用婴儿血清(C5)
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序列表
Intercell Biomedizinische Forschungs-und Entwicklungs AGCistem Biotechnologies GmbH
R 39035
优先权:2001年1月26日的奥地利专利申请号A 130/2001
Seq.ID Nos.1-598
生物体:金黄色葡萄球菌;表皮葡萄球菌
1. | atgaacaaacagcaaaaagaatttaaatcattttattcaattagaaagtcatcactaggcgttgcatctgtagcaattagtacacttttattattaatgtcaaatggcgaagcacaagcagcagctgaagaaacaggtggtacaaatacagaagcacaaccaaaaactgaagcagttgcaagtccaacaacaacatctgaaaaagctccagaaactaaaccagtagctaatgctgtctcagtatctaataaagaagttgaggcccctacttctgaaacaaaagaagctaaagaagttaaagaagttaaagcccctaaggaaacaaaagaagttaaaccagcagcaaaagccactaacaatacatatcctattttgaatcaggaacttagagaagcgattaaaaaccctgccataaaagacaaagatcatagcgcaccaaactctcgtccaattgattttgaaatgaaaaagaaagatggaactcaacagttttatcattatgcaagttctgttaaacctgctagagttattttcactgattcaaaaccagaaattgaattaggattacaatcaggtcaattttggagaaaatttgaagtttatgaaggtgacaaaaagttgccaattaaattagtatcatacgatactgttaaagattatgcttacattcgcttctctgtatcaaacggaacaaaagctgttaaaattgttagttcaacacacttcaataacaaagaagaaaaatacgattacacattaatggaattcgcacaaccaatttataacagtgcagataaattcaaaactgaagaagattataaagctgaaaaattattagcgccatataaaaaagcgaaaacactagaaagacaagtttatgaattaaataaaattcaagataaacttcctgaaaaattaaaggctgagtacaagaagaaattagaggatacaaagaaagctttagatgagcaagtgaaatcagctattactgaattccaaaatgtacaaccaacaaatgaaaaaatgactgatttacaagatacaaaatatgttgtttatgaaagtgttgagaataacgaatctatgatggatacttttgttaaacaccctattaaaacaggtatgcttaacggcaaaaaatatatggtcatggaaactactaatgacgattactggaaagatttcatggttgaaggtcaacgtgttagaactataagcaaagatgctaaaaataatactagaacaattattttcccatatgttgaaggtaaaactctatatgatgctatcgttaaagttcacgtaaaaacgattgattatgatggacaataccatgtcagaatcgttgataaagaagcatttacaaaagccaataccgataaatctaacaaaaaagaacaacaagataactcagctaagaaggaagctactccagctacgcctagcaaaccaacaccatcacctgttgaaaaagaatcacaaaaacaagacagccaaaaagatgacaataaacaattaccaagtgttgaaaaagaaaatgacgcatctagtgagtcaggtaaaggcgtaacgcttgctacaaaaccaactaaaggtgaagtagaatcaagtagtacaactccaactaaggtagtatctacgactcaaaatgttgcaaaaccaacaactggttcatcaaaaacaacaaaagatgttgttcaaacttcagcaggttctagcgaagcaaaagatagtgctccattacaaaaagcaaacattaaacacacaaatgatggacacactcaaagccaaaacaataaaaatacacaagaaaataaagcaaaatcattaccacaaactggtgaagaatcaaataaagatatgacattaccattaatggcattattagctttaagtagcatcgttgcattcgtattacctagaaaacgtaaaaactaa |
2. | atgagaaatatagagaatctaaatcccggagattcagttgatcactttttcttagtgcataaagctacacagggtgtaacagcacaaggtaaagattatatgacattacatttgcaagataaaagtggtgaaattgaagcgaaattttggacggctacaaaaaatgatatggcaacaatcaagcctgaagaaattgtacatgttaaaggtgacatcataaactatcgcggaaataaacagatgaaagtcaaccaaattagactagcgacaactgaagatcaattaaaaacagaacaatttgtagatggtgcacctttatcaccggcagaaatacaagaagagatttctcattatttgctagatattgaaaatgctaatttacaacgtatcacacgtcatttattgaaaaaatatcaagaacgattttacacatatccagctgctagttctcatcatcataactttgcgagtggcttaagctatcatgtattaacgatgttacgtattgcaaaatcaatttgtgacatttatccattgttaaacaaaagtttgttatatagtggtattattttgcatgatattggtaaagttagagaattgagtggtcctgttgcgacgtcgtatacagtcgaaggtaacttattaggacacatctcgattgcgagtgatgaagtagttgaagcagctcgtgaattgaacattgaaggagaagaaatcatgttgttaagacatatgattttatctcatcatggtaagttagagtatggttctccaaaactgccatacttaaaagaagcagaaattttatgctatatcgataatatcgatgctagaatgaatatgtttgaaaaggcatataaaaaaactgacaagggtcagtttacagataaaatatttggtcttgaaaatcgtagattctacaatcctgaatcactcgat |
3. | atgaacaaacatcacccaaaattaaggtctttctattctattagaaaatcaactctaggcgttgcatcggtcattgtcagtacactatttttaattacttctcaacatcaagcacaagcagcagaaaatacaaacactccagataaaatctcggaaaatcaaaataataatgcaactacaactcagccacctaaggatacaaatcaaacacaacctgctacgcaaccagcaaacactgcgaaaaactatcctgcagcggatgaatcactcaaagatgcaattaaagatcctgcattagaaaataaagaacatgatataggtccaagagaacaagtcaatttccagttattagataaaaacaatgaaacgcagtactatcactttttcagcatcaaagatccagcagatgtgtattacactaaaaagaaagcagaagttgaattagacatcaatactgcttcaacatggaagaagtttgaagtctatgaaaacaatcaaaaattgccagtgagacttgtatcatatagtcctgtaccagaagaccatgcctatattcgattcccagtttcagatggcacacaagaattgaaaattgtttcttcgactcaaattgatgatggagaagaaacaaattatgattatactaaattagtatttgctaaacctatttataacgatccttcacttgtaaaatcagatacaaatgatgcagtagtaacgaatgatcaatcaagttcagtcgcaagtaatcaaacaaacacgaatacatctaatcaaaatacatcaacgatcaacaatgctaataatcaaccgcaggcaacgaccaatatgagtcaacctgcacaaccaaaatcgtcaacgaatgcagatcaagcgtcaagccaaccagctcatgaaacaaattctaatggtaatactaacgataaaacgaatgagtcaagtaatcagtcggatgttaatcaacagtatccaccagcagatgaatcactacaagatgcaattaaaaacccggctatcatcgataaagaacatacagctgataattggcgaccaattgattttcaaatgaaaaatgataaaggtgaaagacagttctatcattatgctagtactgttgaaccagcaactgtcatttttacaaaaacaggaccaataattgaattaggtttaaagacagcttcaacatggaagaaatttgaagtttatgaaggtgacaaaaagttaccagtcgaattagtatcatatgattctgataaagattatgcctatattcgtttcccagtatctaatggtacgagagaagttaaaattgtgtcatctattgaatatggtgagaacatccatgaagactatgattatacgctaatggtctttgcacagcctattactaataacccagacgactatgtggatgaagaaacatacaatttacaaaaattattagctccgtatcacaaagctaaaacgttagaaagacaagtttatgaattagaaaaattacaagagaaattgccagaaaaatataaggcggaatataaaaagaaattagatcaaactagagtagagttagctgatcaagttaaatcagcagtgacggaatttgaaaatgttacacctacaaatgatcaattaacagatttacaagaagcgcattttgttgtttttgaaagtgaagaaaatagtgagtcagttatggacggctttgttgaacatccattctatacagcaactttaaatggtcaaaaatatgtagtgatgaaaacaaaggatgacagttactggaaagatttaattgtagaaggtaaacgtgtcactactgtttctaaagatcctaaaaataattctagaacgctgattttcccatatatacctgacaaagcagtttacaatgcgattgttaaagtcgttgtggcaaacattggttatgaaggtcaatatcatgtcagaattataaatcaggatatcaatacaaaagatgatgatacatcacaaaataacacgagtgaaccgctaaatgtacaaacaggacaagaaggtaaggttgctgatacagatgtagctgaaaatagcagcactgcaacaaatcctaaagatgcgtctgataaagcagatgtgatagaaccagagtctgacgtggttaaagatgctgataataatattgataaagatgtgcaacatgatgttgatcatttatccgatatgtcggataataatcacttcgataaatatgatttaaaagaaatggatactcaaattgccaaagatactgatagaaatgtggataaagatgccgacaatagcgttggtatgtcatctaatgtcgatactgataaagactctaataaaaataaagacaaagtcatacagctgaatcatattgccgataaaaataatcatactggaaaagcagcaaagcttgacgtagtgaaacaaaattataataatacagacaaagttactgacaaaaaaacaactgaacatctgccgagtgatattcataaaactgtagataaaacagtgaaaacaaaagaaaaagccggcacaccatcgaaagaaaacaaaattagtcaatctaaaatgctaccaaaaactggagaaacaacttcaagccaatcatggtggggcttatatgcgttattaggtatgttagctttattcattcctaaattcagaaaagaatctaaa |
4. | AtgtcagattttaatcatacagatcattctacaacaaaccatagccaaacacctagatacAgaagacctaaatttccatggtttaaaacagtcatcgttgcattgattgctggaattattGgtgcacttctagtacttggtataggcaaagtattaaatagtacaattttaaataaagatGgttcaactgttcagacaacaaataataaaggtggcaatcaattagacggtcaaagcaagAaattcggtaccgttcatgaaatgataaaatctgtctcccctacaattgttggagttattAacatgcaaaaagcatcaagtgtagacgacttattaaaaggcaaatcatctaaaccatctGaagctggagtaggttcaggtgttatctatcaaataaacaacaattcagcttatatcgttAcaaacaatcatgttattgatggcgcaaatgaaattagagtccaattacataataaaaaaCaagttaaagcgaaattagttggtaaagatgcagtaactgatattgctgtacttaaaattGaaaatacaaaaggtattaaagcgattcaatttgccaactcttcaaaagtacaaactggcGatagcgtattcgcaatgggtaacccattaggattacaatttgctaactctgtaacatctGgtatcatttcagcaagcgaacgtacgattgacgctgagacaactggtggcaatacaaaaGttagcgttcttcaaacagatgctgctattaacccaggtaactcaggtggcgcattagtaGatattaatggtaatttagttggtattaactcaatgaaaattgctgcgacacaagttgaaGgtatcgggtttgctattccaagtaatgaagttaaagtaacaattgaacaacttgtaaaaCatggtaaaattgaccgcccttcgattggtattggtttaattaatttgaaagatattcctGaagaagagcgcgagcaacttcatactgatagagaagacggtatttatgtcgccaaagctGatagtgatattgatcttaaaaaaggtgatattattacagaaattgatggcaagaaaattAaagatgatgttgatttaagaagctatttatatgaaaataaaaaacctggtgaatcagtcActgttaccgttatccgtgatggtaaaacaaaagaagttaaagtgaaattaaaacaacaaAaagaacaaccaaaacgtcaaagccgatcagaacgtcaatcacctggccaaggcgatagagatttctttaga |
5. | ttgatgattaatgaaagagaagtgtttattttgatatatctagataatgcggcamcgacgaaagcatttgaagaagtgttagatacttatttaaaagtaaatcaatcaatgtattataatccgaatagtccgcataaagctggtttgcaggcaaatcaattactacaacaagcaaaaacccaaattaatgcaatgattaattcaaaaacaaattatgatgttgtattcactagtggtgcaactgaatccaataatcttgctttaaaaggtattgcctatcgtaaatttgatacagcgaaggaaataattacatccgtgttagagcatccgtccgtattagaggttgtaagatatttggaagcacacgaaggatttaaagttaaatatgttgatgtaaagaaagatggcagtattaacttagaacacttcaaagaattaatgtcagacaaagtcggtttagtaacatgtatgtatgtaaataatgtaactggacaaatacagcctattccacaaatggctaaagttataaaaaattatcctaaggcacattttcatgtagatgcggttcaagcattcggcaaaatttcaatggatctcaataacatagatagtattagtttaagtggacacaagtttaatggtttaaaaggacaaggcgtcttacttgtaaatcacattcaaaatgttgaaccaactgtccatggtggtggtcaagaatatggcgttagaagtggaacagttaatttgccaaatgatattgcaatggttaaagcgatgaagatagctaatgaaaactttgaagcattgaatgcatttgttactgagttaaataatgacgtccgtcaatttttaaataaatatcatggagtttatattaattcttcaacttcaggttcaccattcgttttaaatattagttttcctggcgtaaaaggtgaagtattagttaatgctttttcaaaatatgacattatgatatctacgacaagtgcttgttcatctaaacgtaataaattaaatgaagtattggctgcaatgggattatcagacaaatctattgaaggtagtataagattatcatttggggctactacaactaaagaagatatagcgaggtttaaagaaatatttatcatcatttatgaggaaattaaggagttgataaaa |
6. | gtgaaccaacaacaggagaaaacaacaacaacgccaacaacaattaatccattaacgggagaaaaagtaggcgaaggtgaaccaacaccagaagtaacaaaagaaccagtagatgaaatcacacaattcggtggagaagaagtaccacaaggtcataaagatgagttcgatccaaacttaccaattgacggtacagaagaagtaccaggtaaaccaggcatcaagaatcctgaaacaggtgaagtagtaacacctccggttgacgatgtcacaaaacatggtccaaaagcaggcgaaccagaggttactaaagaagaaataccattcgagaaaaaacgtgagttcaatccagacttaaaaccaggtgaagagaaagtaacgcaagaaggacaaactggagagaaaacaacaacaacgccaacaacaattaatccattaacgggagaaaaagtaggcgaaggtgaaccaacaacagaagtaacaaaagaaccagtagatgaaatcacacaattcggtggagaagaagtaccacaaggtcataaagatgagttcgatccaaacttaccaattgacggtacagaagaagtaccaggtaaaccaggcatcaagaatcctgaaacaggtgaagtagtaacaccaccagtagacgatgtcacaaaacatggtccaaaagcaggcgaaccagaggttactaaagaagaaattccatatgaaactaaacgcgtattagatccaacaatggaaccaggtagtcctgataaagtagctcaaaaaggtgaaaatggtgaaaaaacaacaacaacaccaactacaattaatccattaacgggagaaaaagtaggcgaaggcgaaccaacaacggaagtaacgaaagaaccaacagacgaaattgttaactatgcacctgaaattattcctcatggtacacgtgaagaaattgatccaaacttaccagaaggtgaaactaaagttatcccaggtaaagatggcttgaaagatcctgaaactggagaaatcattgaagaaccacaagatgaagtaatcatccatggtgctaaagatgattcagatgcggacagcgattcagacgcagatagcgattctgatgcagacagcgactcagacgcagatagcgactctgatgcggacagcgattcagacagcgatagcgattcagattcagatagcgactctgatgcggacagcgattcagacgcagacagcgattcagattcagatagtgactctgatgcggacagcgactcagacgcagatagcgactctgatgcggacagcgactcagacgcagatagcgattctgattcagacagcgactcagacgcagatagcgactcagattcagacagcgattcagacgcagatagcgactcagacgcagatagcgattcagacgcagatagcgactcagacgcagatagcgattcagattcagatagcgactctgatgcggacagcgatagcgattcagattcagacagcgactcagacgcagatagcgattcagacagcgattcagacgcagatagcgactctgatgcggacagcgactcagacgcagatagcgactcagacgcagatagcgattcagattcagacagcgactcagattcagacagcgatagcgattcagattcagacagagactcagacgcagatagcgactcagacgcagatagcgactcagattcagacagcgattcagacgcagatagcgattcagattcagatagtgactctgatgcggacagcgattcagacgcagatagcgactcagattcagacgcagatagcgattctgattcagacagcgactcagacgcagatagcgactctgatgcggacagcgactcagacgcagatagcgattctgatgcagacagcgactcagacagcgatagcgattctgattcagacagcgattcagacgcagatagcgactctgatgcggacagcgattcagacgcagatagagatcataatgacaaaacagataaaccaaataataaagagttaccagatactggtaatgatgctcaaaataatggcacattatttggttcactattcgctgcgcttggaggattattcttagttggcagacgtcgtaaaaacaaaaataatgaagaaaaa |
7. | gtgaagtcattgaagacggtgattgggatgaataataaggagcatattaaatctgtcattttagcactactcgtcttgatgagtgtcgtattgacatatatggtatggaacttttctcctgatattgcaaatgtcgacaatacagatagtaagaagagtgaaacgaaacctttaacgacacctatgacagccaaaatggatacaactattacgccatttcagattattcattcgaaaaatgatcatccagaaggaacgattgcgacggtatctaatgtgaataaactgacgaaacctttgaaaaataaagaagtgaagtccgtggaacatgttcgtcgtgatcataacttgatgattcctgatttgaacagtgattttatattattcgattttacgtatgatttaccgttatcaacatatcttggtcaagtactgaacatgaatgcgaaagtaccaaatcatttcaatttcaatcgtttggtcatagatcatgatgctgatgataatatcgtgctttatgctataagcaaagatcgccacgattacgtaaaattaacaactacaacgaaaaatgatcattttttagatgcattagcagcagtgaaaaaagatatgcaaccatacacagatatcatcacaaacaaagatacaattgatcgtacgacgcatgtttttgcaccaagtaaacctgaaaagttaaaaacatatcgcatggtatttaacacgattagtgttgagaaaatgaatgctatactatttgacgattcaaccatcgttcgtagttcaaagagtggtgttacaacctacaacaataatacaggtgtcgcaaactataacgataaaaatgaaaaatatcattataaaaacctgtccgaagatgaagcgagttccagcaaaatggaagaaacgattccaggaacctttgattttattaatggtcatggtggtttcttaaacgaagacttcagattgtttagtacgaataatcagtcaggcgagttaacatatcaacgtttccttaatggttatccaacgtttaataaagaaggttctaatcaaattcaagtcacttggggtgaaaaaggcgtctttgactatcgtcgttcgttattacgcaccgacgttgttttaaatagtgaggataataaatcgttgccgaaattagagtctgtacgttcaagcttagcgaacaatagtgatattaattttgaaaaagtaacaaacatcgctatcggttacgaaatgcaggataattcagatcataatcacattgaagtgcagattaacagtgaactcgtaccgcgttggtatgtagaatatgatggcgaatggtatgtttataacgatgggaggcttgaa |
8. | atgagtaaaagacagaaagcatttcatgacagcttagcaaacgaaaaaacaagagtaagactttataaatctggaaaaaattgggtaaaatccggaattaaagaaatagaaatgttcaaaattatggggctaccatttattagtcatagtttagtgagtcaagataatcaaagcattagtaaaaaaatgacgggatacggactgaaaactacggcggttattggtggtgcattcacggtaaatatgttgcatgaccagcaagcttttgcggcttctgatgcaccattaacttctgaattaaacacacaaagtgaaacagtaggttatcaaaactcaacgacaatcgaagcatcaacatcaacagccgattccacaagtgtaacgaaaaatagtagttcggtacaaacatcaaatagtgacacagtctcaagtgaaaagtctgaaaaggtcacttcgacaactaacagtacaagcaatcaacaagagaaattgacatctacatcagaatcaacatcctcaaagaatactacatcaagttctgatactaaatctgtagcttcaacttcaagtacagaacaaccaattaatacatcaacaaatcaaagtactgcatcaaataacacttcacaaagcacaacgccatcttcggtcaacttaaacaaaactagcacaacgtcaactagcaccgcaccagtaaaacttcgaactttcagtcgcttagctatgtcaacatttgcgtcagcagcgacgacaaccgcagtaactgctaatacaattacagttaataaagataacttaaaacaatatatgacaacgtcaggtaatgctacctatgatcaaagtaccggtattgtgacgttaacacaggatgcatacagccaaaaaggtgctattacattaggaacacgtattgactctaataagagttttcatttttctggaaaagtaaatttaggtaacaaatatgaagggcatggaaatggtggagatggtatcggttttgccttttcaccaggtgtattaggtgaaacagggttaaacggtgccgcagtaggtattggtggcttaagtaacgcatttggcttcaaattggatacgtatcacaatacatctaaaccaaattcagctgcaaaggcgaatgctgacccatctaatgtagctggtggaggtgcgtttggtgcatttgtaacaacagatagttatggtgttgcgacaacgtatacatcaagttcaacagctgataatgctgcgaagttaaatgttcaacctacaaataacacgttccaagattttgatattaactataatggtgatacaaaggttatgactgtcaaatatgcaggtcaaacatggacacgtaatatttcagattggattgcgaaaagtggtacgaccaacttttcattatcaatgacagcctcaacaggtggcgcgacaaatttacaacaagtacaatttggaacattcgaatatacagagtctgctgttacacaagtgagatacgttgatgtaacaacaggtaaagatattattccaccaaaaacatattcaggaaatgttgatcaagtcgtgacaatcgataatcagcaatctgcattgactgctaaaggatataactacacgtccgtcgatagttcatatgcgtcaacttataatgatacaaataaaactgtaaaaatgacgaatgctggacaatcagtgacatattattttactgatgtaaaagcaccaactgtaactgtaggcaatcaaaccatagaagtgggtaaaacaatgaatcctattgtattgactacaacggataatggtactgggactgtgacaaatacagttacaggattaccaagcggattaagttacgatagtgcaacgaattcaatcattgggacaccaacaaaaattggtcaatcaacagtgacagttgtgtctactgaccaagcaaataacaaatcgacgacaacttttacaataaatgttgtggatacgacagcaccaacagtgacaccaataggagatcaatcatcagaagtgtattcaccaatatccccgattaaaattgctacgcaagataacagtggaaatgcggtgacgaatacagtgactggattgccatccggactaacatttgatagtacaaataatactatcagtggtacaccaacaaacattggtacaagtactatatcaatcgtttctacagatgcgagcggtaacaaaacgacgacaacttttaaatatgaagtaacaagaaatagcatgagtgattccgtatcaacatcaggaagtacacaacaatctcaaagtgtgtcaacaagtaaagctgactcacaaagtgcatcaacgagtacatcaggatcgattgtggtatctacatcagctagtacctcgaaatcgacaagtgtaagcctatctgattctgtgagtgcatctaagtcattaagcacatctgaaagtaatagtgtatcaagctcaacaagcacaagtttagtgaattcacaaagtgtatcatcaagcatgtcggattcagctagtaaatcaacatcattaagcgattctatttcaaactctagcagtactgaaaaatccgaaagtctatcaacaagtacatctgattcattgcgtacatcaacatcactcagtgactcattaagtatgagtacatcaggaagcttgtctaagtcacaaagcttatcaacgagtatatcagggtcgtctagtacatcagcatcattaagtgacagtacatcgaatgcaattagtacatcaacatcattgagcgagtcagctagcacctcggactctatcagtatttcaaatagcatagccaactctcaaagtgcgtcaacaagcaaatcagattcacaaagtacatcaatatcattaagtacaagtgattcaaaatcgatgagtacatcagaatcattgagcgattcgacgagcacaagtggttctgtttctggatcactaagcatagcagcatcacaaagtgtctcaacaagtacatcagactcgatgagtacttcagagatagtaagtgactctatcagtacaagtgggtcattatctgcatcagacagtaaatcaatgtccgtaagtagttcaatgagcacgtctcagtcaggtagtacatcagaatcattaagtgattcacaaagtacatctgattctgatagtaagtcattatcacaaagtactagtcaatcaggttcaacaagtacatcaacgtcgacaagtgcttcagtacgtacttcggaatcacaaagtacgtctggttcaatgagtgcaagtcaatccgattcaatgagcatatcaacgtcgtttagtgattcaacgagtgatagcaaatcagcatcaactgcatcaagtgaatcaatatcacaaagtgcttctacgagcacatctggttcggtaagtacttcgacatcgttaagtacaagtaattcagaacgtacatcaacatctatgagtgattccacaagcttaagtacatcagagtctgattcaataagtgaatcaacgtcaacgagcgactctataagtgaagcaatatctgcttcagagagcacgtttatatcattaagtgaatcaaatagtactagcgattcagaatcacaaagtgcatctgcctttttaagtgaatcattaagtgaaagtacgtctgaatcaacatcagagtcagtgagtagttcgacaagtgagagtacgtcattatcagacagtacatcagaatctggtagcacatcaacatcattaagtaattcaacaagtggtagtacgtccatttcaacatcgacaagtatcagtgaatcaacgtcaacgtttaagagcgagagtgtttcaacatcactgagtatgtcaacgagtacaagtttgtctgactctacaagtttgtcaacatcattaagtgattccacaagtgatagtaagtctgattcattaagtacatcaatgtcgacaagtgattcaatcagtacaagtaaatctgattccattagtacatccacatcattaagtggttctacaagtgaaagtaaatccgattcaacatcaatgagcataagtatgtctaaatcaacatcaggaagtacaagtacgtcaacgagtacaagtttgtctgactcaacgagtacatcattgtcactaagtgcctcaatgaatcaaagcggagtagactcaaactcagcaagccaaagtgcctcaaactcaacaagtacaagcacgagcgaatccgattcacaaagcacatcatcatatacaagtcagtcaacaagccaaagtgaatccacatcgacatcaacgtcactaagcgattcaacaagtatatctaaaagtacgagtcaatcaggttcggtaagcacatcagcgtcattaagtggttcagagagtgaatctgattcacaaagtatctcaacaagtgcaagtgagtcaacatcagaaagtgcgtcaacatcactcagtgactcaacaagtacaagtaactcaggatcagcaagtacgtcaacatcgctcagtaactcagcaagcgcaagtgaatccgatttgtcgtcaacatctttaagtgattcaacatctgcgtcaatgcaaagcagtgaatccgattcacaaagcacatcagcatcattaagtgattcgctaagtacatcaacttcaaaccgcatgtcgaccattgcaagtttatctacatcggtaagtacatcagagtctggctcaacatcagaaagtacaagtgaatccgattcaacatcaacatcattaagcgattcacaaagcacatcaagaagtacaagtgcatcaggatcagcaagtacatcaacatcaacaagtgactctcgtagtacatcagcttcaactagtacttcgatgcgtacaagtactagtgattcacaaagtatgtcgctttcgacaagtacatcaacaagtatgagtgattcaacgtcattatctgatagtgttagtgattcaacatcagactcaacaagtgcgagtacatctggttcgatgagtgtgtctatatcgttaagtgattcgacaagtacatcaacatcggctagtgaagtaatgagcgcaagcatatctgattcacaaagtatgtcagaatctgtaaatgattcagaaagtgtaagtgaatctaattctgaaagtgactctaaatcgatgagtggctcaacaagtgtcagtgattatggctcattgagcgtctcaacgtcattaagaaaatcagaaagtgtaagcgagtcaagttcattgagttgctcacaatcgatgagcgattcagtaagcacaagcgattcgtcatcatcaagtgtatcgacgtaactaagaagttaagaaagcgtgagtgaatctgattcattaagtgattcaaaatcaacaagtggttcgacttcaacaagtacatctggttcattgagtacctcaacatcattaagtggttcagaaagcgcaagcgagtatacctcgctaagtgattcaacatcaatgagtgattctactagtacaagtgactccgactcattaagtggatcaatatctttaagtggttccacaagtcttagcacttcggattcattaagtgattca |
aaatcattgagtagctcgcaaagtatgagtggatcagaatcaacgtcaacaagtgtgagcgattcgcagtcaagctcaacaagtaatagtcaatttgactctatgagcatcagtgcatcagaaagcgactcaatgtctacaagtgattcgtctagcatcagtggatcaaattcaacgagtacatcactttcaacatctgactcaatgagcggaagcgtatcagtttcaacatcgacaagtttaagtgactcaatatcaggttcaacaagtgtaagtgactcgagctcaacaagcacatctacatcattaagtgattcaatgtcacaaagccagtcaacaagtacaagtgcatctggttccttaagtacatcgatatcaacatcaatgtcaatgagtgctagtacatcgtcatcacaaagcacatcggtgtcgacatcatcatcaacatcagacagtatcagtgattctacttcaataagtatcagtggttcacaaagtacagtagaatcagaatctacaagtgattcaacttctatcagtgactcagaatcattgagtacatcagattcagactcgacatcgacaagtacatcggactcaacaagtggttcaacttcaacaagcatatctgaatcattaagtacgtctggttcaggttcaacgagcgtatctgactcaacatcaatgagtgaatctaattcatcgagtgtttcaatgtcacaagacaaatccgactcaacatcaattagtgactcagaatcagtgtcaacaagcacatcaacgtcattgagcacatccgattcgacaagcacatccgaatcactgagtacatctatgtctggttcacaaagcatttctgactcaacatcaacaagtatgtccggctcaacaagtacatctgaatctaactcaatgcatccgtcagactcaatgagtatgcatcatactcacagcacgagcacatctcgcttatcaagtgaagcaacaacgagcacgagtgaatctcagtctacattaagtgcaacatctgaagtgactaaacataatggcacaccagcacaaagtgaaaaaagattgccagatacaggtgactcaataaaacaaaatggattactaggtggcgttatgacattattagttggtttaggtttaatgaagagaaagaaaaagaaagatgaaaatgatcaagatgattctcaagca |
9. | atgcctaaaaataaaattttaatttatttgctatcaactacgctcgtattacctactttagtttcacctaccgcttatgctgatacacctcaaaaagatactacagctaagacaacatctcatgattcaaaaaaatctaatgacgatgaaacttctaaggatactacaagtaaagatattgataaagcagacaaaaataatacaagtaaccaagacaataacgacaaaaaatttaaaactatagacgacagcacttcagactctaacaatatcattgattttatttataagaatttaccacaaaccaatataaaccaattgctaaccaaaaataaatacgatgataattactcattaacaactttaatccaaaacttattcaatttaaattcggatatttctgattacgaacaacctcgtaatggcgaaaagtcaacaaatgattcgaataaaaacagtgacaatagcatcaaaaatgacactgatacgcaatcatctaaacaagataaagcagacaatcaaaaagcacctaaatcaaacaatacaaaaccaagtacatctaataagcaaccaaattcgccaaagccaacacaacctaatcaatcaaatagtcaaccagcaagtgacgataaagcaaatcaaaaatcttcatcgaaagataatcaatcaatgtcagattcggctttagactctattttggatcaatacagtgaagatgcaaagaaaacacaaaaagattatgcatctcaatctaaaaaagacaaaaatgaaaaatctaatacaaagaatccacagttaccaacacaagatgaattgaaacataaatccaaacctgctcaatcattcaacaacgatgttaatcaaaaggatacacgtgcaacatcattattcgaaacagatcctagtatatctaacaatgatgatagcggacaatttaacgttgttgactcaaaagatacacgtcaatttgtcaaatcaattgctaaagatgcacatcgcattggtcaagataacgatatttatgcgtctgtcatgattgcccaagcaatcttagaatctgactcaggtcgtagtgctttagctaagtcaccaaaccacaatttattcggtatcaaaggtgcttttgaagggaattctgttccttttaacacattagaagctgatggtaatcaattgtatagtattaatgctggattccgaaaatatccaagcacgaaagaatcactaaaagattactctgaccttattaaaaatggtattgatggcaatcgaacaatttataaaccaacatggaaatcggaagccgattcttataaagatgcaacatcacacttatctaaaacatatgctacagatccaaactatgctaagaaattaaacagtattattaaacactatcaattaactcagtttgacgatgaacgcatgccagatttagataaatatgaacgttctatcaaggattatgatgattcatcagatgaattcaaacctttccgtgaggtatctgatagtatgccatatccacatggccaatgtacttggtacgtatataaccgtatgaaacaatttggtacatctatctcaggtgatttaggtgatgcacataattggaataatcgagctcaataccgtgattatcaagtaagtcatacaccaaaacgtcatgctgctgttgtatttgaggctggacaatttggtgcagatcaacattacggtcatgtagcatttgttgaaaaagttaacagtgatggttctatcgttatttcagaatccaatgttaaaggattaggtatcatttctcatagaactatcaacgcagctgccgctgaagaattatcatatattacaggtaaa |
10. | gtgaggaaattttcaagatatgcatttacaagtatggcagcattaaccttgttgagcactttatcaccagcagcattagcgattgattcaaaaaataaaccagctaattctgatattaaatttgaggtgactcaaaagagtgatgcggtcaaagcattaaaagaattgcctaaatccgaaaatgtaaaaaatatttatcaagattacgctgttactgatgtaaaaactgataaaaaaggatttacgcattatacattgcaaccgagtgttgatggtgttcatgcacctgacaaagaagtgaaagtacacgcagacaaatcaggaaaagtcgttttaatcaatggggatactgatgcgaagaaagtaaagccaacgaataaagtgacattaagtaaagatgacgcagccgacaaagaatttaaagcagttaagattgataagaataaagcgaaaaatcttaaagataaagtcattaaagaaaacaaagttgaaatcgatggtgacagtaataaatacgtttataatgttgagttaattacagtgacaccagaaatttcacattggaaagttaaaattgatgctcaaactggcgaaattttagaaaaaatgaacttagttaaagaagctgcagaaactggtaaaggaaaaggtgtacttggcgatacaaaagatatcaatatcaatagtattgacggtggatttagcctagaagatttaacgcatcaaggtaaattatcagcatttagctttaatgatcaaacaggtcaagcaacattgattaccaatgaagatgaaaacttcgtaaaagatgagcaacgtgctggcgtagatgcaaattattacgctaaacaaacatatgattatcacaaagacacatttggtcgtgaatcatatgacaaccaaggtagtccaattgtttcattaacgcatgttaataactacggtggtcaagataacagaaataatgccgcatggatcggtgacaaaatgatctatggtgatggtgatggtcgcacattcacaagtttatcgggtgcaaatgacgtagtagcacacgaattaacacacggtgtgacacaagagacagcgaacttagaatataaggaccagtcaggcgctctaaatgaaagcttttcagatgtttttggatactttgtagatgacgaggatttcttaatgggtgaagatgtctacacacctggaaaagagggagacgctttacgcagcatgtcaaacccagaacaatttggtcaaccagctcatatgaaagactatgtattcactgaaaaagataatggtggcgtacatacgaattctggaattccaaataaagcagcttataacgtgattcaagcaatagggaaatctaaatcagaacaaatttactaccgagcattaacggaatacttaacaagtaattcaaacttcaaagattgtaaagatgcattataccaagcggctaaagatttatatgacgagcaaacagctgaacaggtgtatgaagcatggaatgaagtaggcgtggag |
11. | ttgaaaaaaagaattgattatttgtcgaataagcagaataagtattcgattagacgttttacagtaggtaccacatcagtaatagtaggggcaactatactatttgggataggcaatcatcaagcacaagcttcagaacaatcgaacgatacaacgcaatcttcgaaaaataatgcaagtgcagattccgaaaaaaacaatatgatagaaacacctcaattaaatacaacggctaatgatacatctgatattagtgcaaacacaaacagtgcgaatgtagatagcacaacaaaaccaatgtctacacaaacgagcaataccactacaacagagccagcttcaacaaatgaaacacctcaaccgacggcaattaaaaatcaagcaactgctgcaaaaatgcaagatcaaactgttcctcaagaagcaaattctcaagtagacaataaaacaacgaatgatgctaatagcatagcaacaaacagtgagcttaaaaattctcaaacattagatttaccacaatcatcaccacaaacgatttccaatgcgcaaggaactagtaaaccaagtgttagaacgagagctgtacgtagtttagctgttgctgaaccggtagtaaatgctgctgatgctaaaggtacaaatgtaaatgataaagttacggcaagtaatttcaagttagaaaagactacatttgaccctaatcaaagtggtaacacatttatggcggcaaattttacagtgacagataaagtgaaatcaggggattattttacagcgaagttaccagatagtttaactggtaatggagacgtggattattctaattcaaataacacgatgccaattgcagacattaaaagtacgaatggcgatgttgtagctaaagcaacatatgatatcttgactaagacgtatacatttgtctttacagattatgtaaataataaagaaaatattaacggacaattttcattacctttatttacagaccgagcaaaggcacctaaatcaggaacatatgatgcgaatattaatattgcggatgaaatgtttaataataaaattacttataactatagttcgccaattgcaggaattgataaaccaaatggcgcgaacatttcttctcaaattattggtgtagatacagcttcaggtcaaaacacatacaagcaaacagtatttgttaaccctaagcaacgagttttaggtaatacgtgggtgtatattaaaggctaccaagataaaatcgaagaaagtagcggtaaagtaagtgctacagatacaaaactgagaatttttgaagtgaatgatacatctaaattatcagatagctactatgcagatccaaatgactctaaccttaaagaagtaacagaccaatttaaaaatagaatctattatgagcatccaaatgtagctagtattaaatttggtgatattactaaaacatatgtagtattagtagaagggcattacgacaatacaggtaagaacttaaaaactcaggttattcaagaaaatgttgatcctgtaacaaatagagactacagtattttcggttggaataatgagaatgttgtacgttatggtggtggaagtgctgatggtgattcagcagtaaatccgaaagacccaactccagggccgccggttgacccagaaccaagtccagacccagaaccagaaccaacgccagatccagaaccaagtccagacccagaaccggaaccaagcccagacccggatccggattcggattcagacagtgactcaggctcagacagcgactcaggttcagatagcgactcagaatcagatagcgattcggattcagacagtgattcagattcagacagcgactcagaatcagatagcgattcagaatcagatagcgactcagattcagatagcgattcagattcagatagcgattcagattcagatagcgattcggattcagacagtgattcagattcagacagcgactcagaatcagatagcgactcagaatcagatagtgagtcagattcagacagtgactcggactcagacagtgattcagactcagatagcgattcagactcagatagcgattcagattcagacagcgactcagattcagacagcgactcagactcagatagcgactcagactcagacagcgactcagattcagatagcgattcagactcagacagcgactcagactcagacagcgactcagactcagatagcgactcagattcagatagcgattcagactcagacagcgactcagattcagatagcgattcggactcagacagcgattcagattcagacagcgactcagactcggatagcgattcagattcagatagcgattcggattcagacagtgattcagattcagacagcgactcagactcggatagcgactcagactcagacagcgattcagactcagatagcgactcagactcggatagcgactcggattcagatagcgactcagactcagatagtgactccgattcaagagttacaccaccaaataatgaacagaaagcaccatcaaatcctaaaggtgaagtaaaccattctaaaaaggtatcaaaacaacacaaaactgatgctttaccagaaacaggagataagagcgaaaacacaaatgcaactttatttggtgcaatgatggcattattaggatcattactattgtttagaaaacgcaagcaagatcataaagaaaaagcg |
12. | atgaaaaagacaattatggcatcatcattagcagtggcattaggtgtaacaggttacgcagcaggtacaggacatcaagcacacgctgctgaagtaaacgttgatcaagcacacttagttgacttagcgcataatcaccaagatcaattaaatgcagctccaatcaaagatggtgcatatgacatccactttgtaaaagatggtttccaatataacttcacttcaaatggtactacatggtcatggagctatgaagcagctaatggtcaaactgctggtttctcaaacgttgcaggtgcagactacactacttcatacaaccaaggttcaaatgtacaatcagtaagctacaatgcacaatcaagtaactcaaacgttgaagctgtttcagctccaacttaccataactacagcacttcaactacttcaagttcagtgagattaagcaatggtaatactgcaggtgctactggttcatcagcagctcaaatcatggctcaacgtactggtgtttcagcttctacatgggctgcaatcatcgctcgtgaatcaaatggtcaagtaaatgcttacaacccatcaggtgcttcaggtttattccaaactatgccaggttggggtccaacaaacactgttgaccaacaaatcaacgcagctgttaaagcatacaaagcacaaggtttaggtgcttggggattc |
13. | ttgggaggatatttaattatgaaaaaaatcgttacagctacaatcgctacagcaggacttgccactatcgcatttgcaggacatgatgcacaagccgcagaacaaaataacaatggatataattctaatgacgctcaatcatacagctatacgtatacaattgatgcacaaggtaattatcattacacttggacaggaaattggaatccaagtcaattaacgcaaaacaacacatactactacaacaactacaatacttatagttataacaatgcatcttacaataactactataatcattcatatcaatacaataactatacaaacaatagtcaaacagcaacaaataactattatactggtggttcaggtgcaagttatagcacaacaagtaataatgttcatgtgactacaactgcagcgccatcttcaaatggtcgttcaatttctaatggttatgcatcaggaagtaacttatatacttcaggacaatgtacttattatgtatttgatcgtgttggtgggaaaattggttcaacatggggtaacgcaagtaattgggctaacgcagctgcatcatctggctatacagtgaacaatacaccaaaagttggtgctatcatgcaaacaacacaaggctattacggtcatgttgcttacgttgaaggcgttaacagcaacggttctgttcgtgtttcagaaatgaactatggacatggtgctggtgtggttacgtctcgtacaatttcagcaaaccaagcaggttcatataatttcattcat |
14. | gtggctaatacgaaaaaaacaacattagatatcactggtatgacttgtgccgcatgttcaaatcgtatcgaaaagaaactgaataaacttgatgacgttaatgcccaagtgaatttaactacagagaaagcaactgttgagtataaccctgatcaacatgatgtccaagaatttattaatacgattcaacatttaggttacggtgtcgctgtagaaactgtcgaattagacattacaggtatgacttgtgctgcatgctcaagccgtattgaaaaagtgttaaataaaatggacggcgttcaaaatgcaacggtcaatttaacaacagagcaagctaaagttgactattatcctgaagaaacagatgctgataaacttgtcactcgcattcaaaaattaggttatgacgcgtctattaaagataacaataaagatcaaacgtcacgcaaagctgaagcgctacaacataaattgattaagcttatcatatcagcagtattatctttaccactattaatgttaatgtttgtacatcttttcaatatgcatataccagcactatttacgaatccatggttccaatttattttagctacacctgtacaatttattattggatggcaattttatgtaggtgcttataaaaacttaagaaatggtggcgccaatatggatgtacttgttgctgttggtacaagtgcagcatatttttacagtatttatgaaatggttcgttggctaaatggctcaacaacgcaaccgcatttatactttgaaacaagcgccgtactaattaccttaatcttattcggtaagtatttagaagctagagcgaagtctcaaacaaccaatgcgcttggcgaattattaagtttacaagctaaagaagcacgcattttaaaagatggtaatgaagtgatgattcctctaaatgaagtacatgttggagatacacttatcgttaaaccaggtgaaaagatacctgttgatggcaaaattattaaaggtatgactgccatcgacgaatctatgttaacaggtgaatctatccctgttgagaagaatgttgatgatactgtaattggttcaacgatgaacaaaaacggtactattactatgacagcaacaaaagttggcggggacaccgcgttggcaaatattattaaagttgtcgaagaagctcaaagttctaaagcgccgattcaacgattggcagatattatttctggttatttcgttcctatcgttgttggtatcgcactattaacatttatcgtgtggattactttagttacaccaggtacatttgaacctgcacttgttgcgagtatttccgttctcgtcattgcttgtccatgcgcattgggacttgctacaccaacttctattatggtaggtactggtcgcgctgctgaaaatggtattttatttaaaggtggcgagtttgttgaacgcacacatcaaattgataccatcgttttagataagacgggtaccattacaaatggtcgtccagtcgtgacagattatcatggtgacaatcaaacgctacaactacttgctactgctgaaaaagattctgaacacccattggcagaagccattgtcaattatgcaaaagaaaagcaattaatattaactgagacaacaacatttaaagcagtacctggccatggcattgaagcaacgattgatcatcaccatatattggttggtaaccgtaaattaatggctgacaatgatattagcttgcctaagcatatttctgatgatttaacacattatgaacgagatggtaaaactgctatgctcattgctgttaattattcattaactggtatcatcgcagtggcagatactgtcaaagatcatgccaaagatgctataaaacaattgcatgatatgggcattgaagttgccatgttaactggcgataataaaaacactgctcaagccattgcaaaacaagtaggcatagatactgttattgcagatattttaccagaagaaaaagctgcacaaattgcgaaactacagcaacaaggtaagaaggttgcgatggttggtgacggtgtaaatgatgcacctgcattagttaaagctgatatcggtatcgccattggtacaggtacagaagttgccattgaagcagctgatattactattcttggtggcgacttgatgcttattcctaaagccatttatgcaagtaaagcaaccattcgtaatattcgtcaaaatctattttgggcattcggctataatattgccggtatccctatagctgcattgggcttacttgcgccatgggttgctggtgctgcaatggcactaagttcagtaagtgttgtcacaaacgcacttagattgaaaaagatgcgattagaaccacgccgtaaagatgcc |
15. | atgtttgattcaattagagagactatagattatgccgtagaaaataatatgtcatttgcggatatcatgtgtaaagaagaaatggaattaagcggtaaatcacgtgatgaagtgcgagcgcaaatgaaacaaaatttagatgtcatgcgagacgcagtaatcaaagggacgacaggtgatggggttgaaagtgtaacgggctacactggtcatgatgctgctaaactacgtgattataatgaaacacatcatgctttgtctggatatgaaatgattgacgcagtcaaaggtgccattgcaacaaatgaagtcaatgctgcgatgggtattatttgtgcaacgccaacagctggttcctcgggtaccattcccggtgcactttttaaattagaaaaaacacatgatttaacagaagagcaaatgattgatttcttattcacttcagcattgtttgggcgtgtcgtagcaaacaatgcaagtgtagctggtgcaacaggtggctgccaagctgaagttggttcagcatctgcaatggccgcagctgcagcagtagctatattcggaggatcaccagaagcatccgggcacgctatggcattagcgataagtaatttattaggtttagtttgtgatccagtagccggacttgttgaaattccttgtgttatgagaaatgcaattggttcgggtaacgctttaatttcagcagatttagcattagcaggtattgaaagtagaatccctgttgatgaagttattgaagcaatggataaggttggtcgtaaccttcctgcatcattacgtgaaactggattgggtggactagcaggcacaccaactggcgaagcaattaaacgtaaaatctttggcacagctgaagatatggttaaaaataat |
16. | gtgaaaaacaatcttaggtacggcattagaaaacataaattgggagcagcatcagtattcttaggaacaatgatcgttgttgggatgggacaagacaaagaagctgcagcatcagaacaaaagacaactacagtagaagaaaatgggaattcagctactgataataaaacaagtgaaacacaaacaactgcaactaacgttaatcatatagaagaaactcaatcatataacgcaacagtaacagaacaaccgtcaaacgcaacacaagtaacaactgaagaagcaccaaaagcagtacaagcaccacaaactgcacaaccagcaaacatagaaacagttaaagaagaggtagttaaagaagaagcgaaacctcaagttaaggaaacaacacaatctcaagacaatagcggagatcaaagacaagtagatttaacacctaaaaaggctacacaaaatcaagtcgcagaaacacaagttgaagtggcacagccaagaacggcatcagaaagtaagccacgtgtgacaagatcagcagatgtagcggaagctaaggaagctagtaacgcgaaagtggaaacgggtacagatgtaacaagtaaagttacagtagaaattggttctattgaggggcataacaatacaaataaagtagaacctcatgcaggacaacgagcggtactaaaatataagttgaaatttgagaatggtttacatcaaggtgactactttgactttactttatcaaataatgtaaatacgcatggcgtatcaactgctagaaaagtaccagaaattaaaaatggttcagtcgtaatggcgacaggtgaagttttagaaggtggaaagattagatatacatttacaaatgatattgaagataaggttgatgtaacggctgaactagaaattaatttatttattgatcctaaaactgtacaaactaatggaaatcaaactataacttcaacactaaatgaagaacaaacttcaaaggaattagatgttaaatataaagatggtattgggaattatcatgccaatttaaatggatcgattgagacatttaataaagcgaataatagattttcgcatgttgcatttattaaacctaataatggtaaaacgacaagtgtgactgttactggaactttaatgaaaggtagtaatcagaatggaaatcaaccaaaagttaggatatttgaatacttgggtaataatgaagacatagcgaagagtgtatatgcaaatacgacagatacttctaaatttaaagaagtcacaagtaatatgagtgggaatttgaatttacaaaataatggaagctattcattgaatatagaaaatctagataaaacttatgttgttcactatgatggagagtatttaaatggtactgatgaagttgattttagaacacaaatggtaggacatccagagcaactttataagtattattatgatagaggatataccttaacttgggataatggtttagttttatacagtaataaagcgaacggaaatgggaaaattggtccgattattcaaaataataaatttgaatataaagaagatacaattaaagaaactcttacaggtcaatatgataagaatttagtaactactgttgaagaggaatatgattcatcaactcttgacattgattaccacacagctatagatggtggaggtggatatgttgatggatacattgaaacaatagaagaaacggattcatcagctattgatatcgattaccatactgctgtggatagcgaagcaggtcacgttggaggatacactgagtcctctgaggaatcaaatccaattgactttgaagaatctacacatgaaaattcaaaacatcacgctgatgttgttgaatatgaagaagatacaaacccaggtggtggtcaggttactactgagtctaacttagttgaatttgacgaagagtctacaaaaggtattgtaactggcgcagtgagcgatcatacaacagttgaagatacgaaagaatatacaactgaaagtaatctgattgaattagtggatgaattacctgaagagcatggtcaagcacaaggaccagtcgaggaaattactgaaaacaatcatcatatttctcattctggtttaggaactgaaaatggtcacgggaattatgacgtgattgaagaaatcgaagaaaatagccacgttgatattaagagtgaattaggttatgaaggtggccaaaatagcggtaaccagtcattcgaggaagacacagaagaagacaaacctaaatatgaacaaggtggcaatatcgtagatatcgattttgatagtgtacctcaaattcatggtcaaaataaaggtaatcagtcattcgaggaagatacagaaaaagacaaacctaagtatgaacatggcggtaacatcattgatatcgacttcgacagtgtgccacatattcacggattcaataagcacactgaaattattgaagaagatacaaataaagataaaccaagttatcaattcggtggacacaatagtgttgactttgaagaagatacacttccaaaagtaagcggccaaaatgaaggtcaacaaacgattgaagaagatacaacacctccaatcgtgccaccaacgccaccgacaccagaagtaccaagtgagccggaaacaccaacgccaccaacaccagaagtaccaagtgagccggaaacaccaacaccaccgacaccagaagtgccgagtgagccagaaactccaacaccgccaacaccagaggtaccagctgaacctggtaaaccagtaccacctgccaaagaagaacctaaaaagccttctaaaccagtggaacaaggtaaagtagtaacacctgttattgaaatcaatgaaaaggttaaagcagtggcaccaactaaaaaaccacaatctaagaaatctgaactacctgaaacaggtggagaagaatcaacaaacaaaggtatgttgttcggcggattattcagcattctaggtttagcattattacgcagaaataaaaagaatcacaaagca |
17. | ttgcatttaagggagaatattatagtgaaaagcaatcttagatacggcataagaaaacacaaattgggagcggcctcagtattcttaggaacaatgatcgttgttggaatgggacaagaaaaagaagctgcagcatcggaacaaaacaatactacagtagaggaaagtgggagttcagctactgaaagtaaagcaagcgaaacacaaacaactacaaataacgttaatacaatagatgaaacacaatcatacagcgcgacatcaactgagcaaccatcacaatcaacacaagtaacaacagaagaagcaccgaaaactgtgcaagcaccaaaagtagaaacttcgcgagttgatttgccatcggaaaaagttgctgataaggaaactacaggaactcaagttgacatagctcaaccaagtaacgtctcagaaattaaaccaagaatgaaaagatcaactgacgttacagcagttgcagagaaagaagtagtggaagaaactaaagcgacaggtacagatgtaacaaataaagtggaagtagaagaaggtagtgaaattgtaggacataaacaagatacgaatgttgtaaatcctcataacgcagaaagagtaaccttgaaatataaatggaaatttggagaaggaattaaggcgggagattattttgatttcacattaagcgataatgttgaaactcatggtatctcaacactgcgtaaagttccggagataaaaagtacagatggtcaagttatggcgacaggagaaataattggagaaagaaaagttagatatacgtttaaagaatatgtacaagaaaagaaagatttaactgctgaattatctttaaatctatttattgatcctacaacagtgacgcaaaaaggtaaccaaaatgttgaagttaaattgggtgagactacggttagcaaaatatttaatattcaatatttaggtggagttagagataattggggagtaacagctaatggtcgaattgatactttaaataaagtagatgggaaatttagtcattttgcgtacatgaaacctaacaaccagtcgttaagctctgtgacagtaactggtcaagtaactaaaggaaataaaccaggggttaataatccaacagttaaggtatataaacacattggttcagacgatttagctgaaagcgtatatgcaaagcttgatgatgtcagcaaatttgaagatgtgactgataatatgagtttagattttgatactaatggtggttattctttaaactttaataatttagaccaaagtaaaaattatgtaataaaatatgaagggtattatgattcaaatgctagcaacttagaatttcaaacacacctttttggatattataactattattatacaagtaatttaacttggaaaaatggcgttgcattttactctaataacgctcaaggcgacggcaaagataaactaaaggaacctattatagaacatagtactcctatcgaacttgaatttaaatcagagccgccagtggagaagcatgaattgactggtacaatcgaagaaagtaatgattctaagccaattgattttgaatatcatacagctgttgaaggtgcagaaggtcatgcagaaggtaccattgaaactgaagaagattctattcatgtagactttgaagaatcgacacatgaaaattcaaaacatcatgctgatgttgttgaatatgaagaagatacaaacccaggtggtggtcaggttactactgagtctaacctagttgaatttgacgaagattctacaaaaggtattgtaactggtgctgttagcgatcatacaacaattgaagatacgaaagaatatacgactgaaagtaatctgattgaactagtagatgaactacctgaagaacatggtcaagcgcaaggaccaatcgaggaaattactgaaaacaatcatcatatttctcattctggtttaggaactgaaaatggtcacggtaattatggcgtgattgaagaaatcgaagaaaatagccacgtggatattaagagtgaattaggttacgaaggtggccaaaatagcggtaatcagtcatttgaggaagacacagaagaagataaaccgaaatatgaacaaggtggcaatatcgtagatatcgatttcgatagtgtacctcaaattcatggtcaaaataatggtaaccaatcattcgaagaagatacagagaaagacaaacctaagtatgaacaaggtggtaatatcattgatatcgacttcgacagtgtgccacatattcacggattcaataagcacactgaaattattgagaaagatacaaataaagataaaccaaattatcaattcggtggacacaatagtgttgactttgaagaagatacacttccacaagtaagtggtcataatgaaggtcaacaaacgattgaagaagatacaacacctccaatcgtgccaccaacgccaccgacaccagaagtaccaagcgagccggaaacaccaacaccaccgacaccagaagtaccaagcgagccggaaacaccaacaccgccaacgccagaggtaccaactgaacctggtaaaccaataccacctgctaaagaagaacctaaaaaaccttctaaaccagtggaacaaggtaaagtagtaacacctgttattgaaatcaatgaaaaggttaaagcagtggtaccaactaaaaaagcacaatctaagaaatctgaactacctgaaacaggtggagaagaatcaacaaacaacggcatgttgttcggcggattatttagcattttaggtttagcgttattacgcagaaataaaaagaatcacaaagca |
18. | atgcaaatgagagataagaaaggaccggtaaataaaagagtagattttctatcaaataaattgaataaatattcaataagaaaatttacagttggaacagcatctattttaattggctcactaatgtatttgggaactcaacaagaggcagaagcagctgaaaacaatattgagaatccaactacattaaaagataatgtccaatcaaaagaagtgaagattgaagaagtaacaaacaaagacactgcaccacagggtgtagaagctaaatctgaagtaacttcaaacaaagacacaatcgaacatgaaccatcagtaaaagctgaagatatatcaaaaaaggaggatacaccaaaagaagtagctgatgttgctgaagttcagccgaaatcgtcagtcactcataacgcagagacacctaaggttagaaaagctcgttctgttgatgaaggctcttttgatattacaagagattctaaaaatgtagttgaatctaccccaattacaattcaaggtaaagaacattttgaaggttacggaagtgttgatatacaaaaaaaaccaacagatttaggggtatcagaggtaaccaggtttaatgttggtaatgaaagtaatggtttgataggagctttacaattaaaaaataaaatagattttagtaaggatttcaattttaaagttagagtggcaaataaccatcaatcaaataccacaggtgctgatggttgggggttcttatttagtaaaggaaatgcagaagaatatttaactaatggtggaatccttggggataaaggtctggtaaattcaggcggatttaaaattgatactggatacatttatacaagttccatggacaaaactgaaaagcaagctggacaaggttatagaggatacggagcttttgtgaaaaatgacagttctggtaattcacaaatggttggagaaaatattgataaatcaaaaactaattttttaaactatgcggacaattcaactaatacatcagatggaaagtttcatgggcaacgtttaaatgatgtcatcttaacttatgttgcttcaactggtaaaatgagagcagaatatgctggtaaaacttgggagacttcaataacagatttaggtttatctaaaaatcaggcatataatttcttaattacatctagtcaaagatggggccttaatcaagggataaatgcaaatggctggatgagaactgacttgaaaggttcagagtttacttttacaccagaagcgccaaaaacaataacagaattagaaaaaaaagttgaagagattccattcaagaaagaacgtaaatttaatccggatttagcaccagggacagaaaaagtaacaagagaaggacaaaaaggtgagaagacaataacgacaccaacactaaaaaatccattaactggagtaattattagtaaaggtgaaccaaaagaagagattacaaaagatccgattaatgaattaacagaatacggacctgaaacaatagcgccaggtcatcgagacgaatttgatccgaagttaccaacaggagagaaagaggaagttccaggtaaaccaggaattaagaatccagaaacaggagacgtagttagaccgccggtcgatagcgtaacaaaatatggacctgtaaaaggagactcgattgtagaaaaagaagarattccattcragaaagaacgtaaatttaatccggatttagcaccagggacagaaaaagtaacaagagaaggacaaaaaggtgagaagacaataacgacgccaacactaaaaaatccattaactggagaaattattagtaaaggtgaatcgaaagaagaaatcacaaaagatccgattaatgaattaacagaatacggaccagaaacgataacaccaggtcatcgagacgaatttgatccgaagttaccaacaggagagaaagaggaagttccaggtaaaccaggaattaagaatccagaaacaggagacgtagttagaccaccggtcgatagcgtaacaaaatatggacctgtaaaaggagactcgattgtagaaaaagaagaaattccattcaagaaagaacgtaaatttaatcctgatttagcaccagggacagaaaaagtaacaagagaaggacaaaaaggtgagaagacaataacgacgccaacactaaaaaatccattaactggagaaattattagtaaaggtgaatcgaaagaagaaatcacaaaagatccgattaatgaattaacagaatacggaccagaaacgataacaccaggtcatcgagacgaatttgatccgaagttaccaacaggagagaaagaggaagttccaggtaaaccaggaattaagaatccagaaacaggagatgtagttagaccaccggtcgatagcgtaacaaaatatggacctgtaaaaggagactcgattgtagaaaaagaagaaattccattcgagaaagaacgtaaatttaatcctgatttagcaccagggacagaaaaagtaacaagagaaggacaaaaaggtgagaagacaataacgacgccaacactaaaaaatccattaactggagaaattattagtaaaggtgaatcgaaagaagaaatcacaaaagatccagttaatgaattaacagaattcggtggcgagaaaataccgcaaggtcataaagatatctttgatccaaacttaccaacagatcaaacggaaaaagtaccaggtaaaccaggaatcaagaatccagacacaggaaaagtgatcgaagagccagtggatgatgtgattaaacacggaccaaaaacgggtacaccagaaacaaaaacagtagagataccgtttgaaacaaaacgtgagtttaatccaaaattacaacctggtgaagagcgagtgaaacaagaaggacaaccaggaagtaagacaatcacaacaccaatcacagtgaacccattaacaggtgaaaaagttggcgagggtcaaccaacagaagagatcacaaaacaaccagtagataagattgtagagttcggtggagagaaaccaaaagatccaaaaggacctgaaaacccagagaagccgagcagaccaactcatccaagtggcccagtaaatcctaacaatccaggattatcgaaagacagagcaaaaccaaatggcccagttcattcaatggataaaaatgataaagttaaaaaatctaaaattgctaaagaatcagtagctaatcaagagaaaaaacgagcagaattaccaaaaacaggtttagaaagcacgcaaaaaggtttgatctttagtagtataattggaattgctggattaatgttattggctcgtagaagaaagaat |
19. | atgaaaaataaatatatctcgaagttgctagttggggcagcaacaattacgttagctacaatgatttcaaatggggaagcaaaagcgagtgaaaacacgcaacaaacttcaactaagcaccaaacaactcaaaacaactacgtaacagatcaacaaaaagctttttatcaagtattacatctaaaaggtatcacagaagaacaacgtaaccaatacatcaaaacattacgcgaacacccagaacgtgcacaagaagtattctctgaatcacttaaagacagcaagaacccagaccgacgtgttgcacaacaaaacgctttttacaatgttcttaaaaatgataacttaactgaacaagaaaaaaataattacattgcacaaattaaagaaaaccctgatagaagccaacaagtttgggtagaatcagtacaatcttctaaagctaaagaacgtcaaaatattgaaaatgcggataaagcaattaaagatttccaagataacaaagcaccacacgataaatcagcagcatatgaagctaactcaaaattacctaaagatttacgtgataaaaacaaccgctttgtagaaaaagtttcaattgaaaaagcaatcgttcgtcatgatgagcgtgtgaaatcagcaaatgatgcaatctcaaaattaaatgaaaaagattcaattgaaaacagacgtttagcacaacgtgaagttaacaaagcacctatggatgtaaaagagcatttacagaaacaattagacgcattagttgctcaaaaagatgctgaaaagaaagtggcgccaaaagttgaggctcctcaaattcaatcaccacaaattgaaaaacctaaagtagaatcaccaaaagttgaagtccctcaaattcaatcaccaaaagttgaggttcctcaatctaaattattaggttactaccaatcattaaaagattcatttaactatggttacaagtatttaacagatacttataaaagctataaagaaaaatatgatacagcaaagtactactataatacgtactataaatacaaaggtgcgattgatcaaacagtattaacagtactaggtagtggttctaaatcttacatccaaccattgaaagttgatgataaaaacggctacttagctaaatcatatgcacaagtaagaaactatgtaactgagtcaatcaatactggtaaagtattatatactttctaccaaaacccaacattagtaaaaacagctattaaagctcaagaaactgcatcatcaatcaaaaatacattaagtaatttattatcattctggaaa |
20. | atggccgtattttcaaaagagaaaaagagaggatgtatcgttgtgatagaaacatttaaagcgtttgtaattgataaagatgagagtggtaaagtgacaccaactttcaaacaattatcgcctactgatttacctaaaggagatgtgctgattaaagtacattactctggtataaattataaagatgctttagcgactcaagaccataatgcagtcgtaaaatcgtatcctatgattccaggaatagatttagctggaacaattgttgaatccgaagcaccaggctttgaaaaaggagaacaagtaattgtaacgagttatgacctaggtgtcagccattatggcggttttagtgaatatgcgcgtgtaaaatcagaatggattatcaagcttcctgatactttaacattagaagaatcaatgatatatggcacagctggttatactgccggtttagcaattgaaagacttgaaaaagttggaatgaatattgaagatggtcctgtactcgttcgcggtgcttcaggtggtgtcggtactttagcagtactcatgcttaatgaacttggttataaagttatcgcaagtacaggtaaacaagatgttagcgatcaattacttgaacttggtgccaaagaagttatcgatcgacttcctgttgaagatgatcataaaaagccactcgcatcatcaacttggcaagcttgtgtagaccctgttggtggcgaaggtattaattatgttacaaagcgtttaaatcatagtgggtcaattgcagttattggtatgactgccggtaatacttatactaattctgtattccctcacattttaagaggtgtaaacattttaggaattgactcggtatttactgctatgaaattaagacagcgcgtttggcgtcgtctcgcaaaagatttaatgcctgaaaatttacatgagatcaagcaagttattacatttgatgaacttccagaacaacttaacaaagtaattaaacatgaaaataaagggcgcattgttatcgatttcggtgtagataaa |
21. | atgaaaaaattagtaacagcaactecgttaacagcaggaatcggcacagcattagtaggtcaagcatatcatgcagatgctgctgaaaattatacaaattacaacaactataactacaacacgactcaaactacaacgactacgacaactacgacaactacatcatcaatttcacattctggtaacttatacactgcaggacaatgtacttggtatgtatatgataaagttggcggagaaatcggttctacttggggaaatgctaataattgggctgctgctgcacaaggtgctggattcacagtaaatcatacaccttctaaaggcgctatcctacaatcttctgaaggaccatttggtcacgttgcatatgtagaaagtgtaaacagtgatggttcagttacaatttcagaaatgaattatagtggcggacctttctcagtaagttctagaactatttctgcaagtgaagcaggtaactacaactacatccatatt |
22. | atgaagaaaatcgctacagctactatcgcaactgcaggattcgctacaatcgcaattgcatcaggaaatcaagctcatgcttctgagcaagataactacggttataatccaaacgacccaacatcatatagctatacttacactattgatgcacaaggtaactaccattacacatggaaaggtaactggcatccaagtcaattaaaccaagataatggctactacagctattactactacaatggttacaataactataacaattacaacaacggttatagctacaataactacagccgttacaacaactactcaaataataatcaatcatataactacaataactataatagttacaacacaaacagctaccgtactggtggtttaggtgcaagctacagcacttcaagcaacaatgttcaagtaactacaactatggctccatcatcaaatggccgttcaatctcaagtggttatacttcaggacgtaacttatacacttctggtcaatgtacatactacgtatttgatcgtgtaggtggtaaaatcggttcaacttggggcaatgcaagtaactgggctaacgcagctgcaagagctggttacacagtgaacaatacaccaaaagctggtgcaattatgcaaacaactcaaggtgcatacggtcacgttgcatacgttgaaagtgttaacagcaatggttcagtaagagtttcagaaatgaactatggttatggcccaggtgttgtaacttcacgtacaatctcagctagccaagctgctggttataacttcattcac |
23. | atgtcaatgacatatagaataaagaaatggcaaaaattatccaccattacgttattaatggctggtgtgattactttgaatggtggtgaattcagaagtgttgataaacatcaaatcgctgtggctgatacgaatgttcaaacgccagattatgaaaaattgaggaacacatggctggacgttaactatggttatgataagtatgatgagaataatccagatatgaagaagaagtttgatgctacagagaaagaggcgacgaatttactcaaggaaatgaaaactgaaagtggtaggaaatacttgtggtcaggagcggaaacccttgaaactaattcttctcatatgactcgtacctatcgtaatattgagaaaatcgcagaagcgatgaggaatcctaaaaccactttaaatactgacgaaaataagaagaaagtgaaagatgcccttgagtggctgcataaaaatgcatatggaaaagaaccagataaaaaagtaaaagaattaagtgagaattttactaaaacaactggcaagaataccaacttaaattggtgggattatgaaattggaacacctaaatcattaacaaatacgcttatattgctgaatgatcaattttcaaatgaagaaaagaaaaaattcactgcccctattaaaactttcgccccagatagtgacaaaatattatcttctgtaggaaaagctgaacttgctaaaggcggaaatctagtagacatttctaaggtgaaacttttagaatgtattatcgaagaagataaagatatgatgaaaaagtctatagattcatttaataaagtcttcactwacgttcaagattctgccactggtaaagaacgtaatggattttataaagatggctcttacattgatcatcaagacgttccatacactggtgcttatggcgttgtactcttagaggggatttctcaaatgatgccgatgataaaagaaacaccttttaatgataaaacccaaaatgatacaaccttaaagtcatggattgacgacggatttatgccactcatttataaaggtgaaatgatggatttatcacgaggtagagctatcagtcgtgaaaatgaaaccagtcactcagcatctgcaacagtaatgaaatcattgttgagattaagtgatgccatggatgattcaacaaaagctaagtataaaaagattgtcaaatcttcagtagagtcagattcaagttataaacaaaatgattatttaaattcatattcggacatagataaaatgaagtctttaatgacagataacagtatttctaaaaacggattaacacaacaacttaaaatatataatgacatggatcgtgtcacctatcataacaaagacttagactttgcatttggtttaagtatgacgtcgaaaaacgtagcacgctatgaaagtatcaacggagagaatttaaaaggttggcacactggtgctggaatgtcttatttatataacagcgatgtcaaacactatcatgataacttctgggtgacagccgatatgaaacgtttatcaggtacaacaactttagacaatgaaatattaaaagatacggatgataaaaagtcgagtaaaacttttgttggcggaacaaaagttgatgaccaacatgctagtatcggaatggattttgaaaatcaggacaaaactttaactgccaaaaaatcatatttcatattaaacgataaaattgtcttcttaggaactggcattaaaagtactgattcatcaaagaatccagttacaacgattgaaaatcgcaaagcgaatgggtatacgttatatacagacgataaacaaacaaccaattctgataatcaggaaaacaattcagtctttttagagtccacagataccaaaaagaacatcggttatcattttttaaacaaaccgaaaataactgtaaaaaaagaaagtcatactggtaagtggaaagaaataaataaaagtcaaaaggatacacaaaaaactgatgagtattatgaagtaactcaaaagcattctaattctgacaataaatatggatatgtgttgtatccaggcttatctaaagatgtctttaagacaaaaaaagatgaagtaactgtcgttaagcaagaagatgacttccacgttgtgaaagataatgaatcggtttgggctggtgttaattatagtaatagcactcaaacttttgacattaacaacactaaagtcgaagttaaagccaaaggtatgtttatacttaaaaagaaagatgataacacttatgaatgtagcttctataatcctgaatctacaaattccgcttcagatattgaatctaaaatttcaatgaccggttactctattacaaacaaaaatacgtcgacttctaatgaatccggcgtgcactttgaattaactaaa |
24. | gtgaatgatttgaagcaatttctatatattgcgttagtatgtggtgtgatagcaggtcttggcgctttcttacatataccgcagtatccgagcatgacaattccacgtatagtagctattttaggaattatcagtgctatcttgacttttaaagacaagcaaatcagcgcctcattaaagtttagcgcattgttaattaatgtgctgccattatgcggtacctttgtagcttcaaat |
25. | gtgtctcgtgaaatgtcatatcattggtttaagaaaatgttactttcaacaagtattttaattttaagtagtagtagtttagggcttgcaacgcacacagttgaagcaaaggataacttaaatggagaaaaaccaactactaatttgaatcataatataacttcaccatcagtaaatagtgaaatgaataataatgagactgggacacctcacgaatcaaatcaaacgggtaatgaaggaacaggttcgaatagtcgtgatgctaatcctgattcgaataatgtgaagccagactcaaacaaccaaaacccaagtacagattcaaaaccagacccaaataaccaaaacccaagtccgaatcctaaaccagatccagataacccgaaaccaaaaccggatccaaaaccagacccagataaaccaaagccaaatccggatccaaaaccagatccagataacccgaaaccaaatccagatccaaaaccagacccagataaaccaaagccaaatccggatccaaaaccagatccagataaaccaaagccaaatccgaatccaaaaccagaccctaataagccaaatcctaacccgtcaccagatcccgatcaacctggggattccaatcattctggtggctcgaaaaatggggggacatggaacccaaatgcttcagatggatctaatcaaggtcaatggcaaccaaatgggaatcaaggaaactcacaaaatcctactggtaatgattttgtatcccaacgatttttagccttggcaaatggggcttacaagtataatccgtatattttaaatcaaattaataagttgggcaaagattatggagaagttactgatgaagacatttataatattattcgaaaacaaaatttcagcggaaatgcatatttaaatggattacaacagcaatcgaattactttagattccaatatttcaatccattgaaatcagaaaggtactatcgtaatttagatgaacaagtactcgcattaattactggtgaaattggatcaatgccagatttgaaaaagcccgaagataagccggattcaaaacaacgctcatttgaaccgcatgaaaaagacgattttacagtagttaaaaaacaagaagataataagaaaagtgcgtcaactgcatatagtaaaagttggctagcaattgtatgttctatgatggtggtattttcaatcatgctattcttatttgtaaagcgaaataaaaagaaaaataaaaacgaatcacagcgacga |
26. | atgaaaaataaaaaacgtgttttaatagcgtcatcattatcatgtgcaattttattgttatcagcagcaacgactcaagcaaattcagctcataaagactctcaagaccaaaataagaaagaacatgttgataagtctcaacaaaaagacaaacgtaatgttactaataaagataaaaattcaacagcaccggatgatattgggaaaaacggtaaaatcacaaaacgaactgaaacagtatatgatgagaaaacaaatatactccaaaatttacaattcgactttatcgatgatccaacttatgacaagaatgtattacttgttaaaaaacaaggctcaattcattcaaatttaaagtttgaatctcataaagaagaaaaaaattcaaattggttaaagtatccaagtgagtaccatgtagattttcaagtaaaaagaaatcgtaaaactgaaatattagaccaattgccgaaaaataaaatttcaactgcaaaagtagacagtacattttcatatagctcaggtggtaaattcgattcaacaaaaggtattggacgaacttcatcaaatagctactccaaaacgattagttataatcagcaaaattatgacacaattgccagcggtaaaaataataactggcatgtacactggtcagttattgcgaatgacttgaagtatggtggagaagtgaaaaatagaaatgatgaattattattctatagaaatacgagaattgctactgtagaaaaccctgaactaagctttgcttcaaaatatagatacccagcattagtaagaagtggctttaatccagaatttttaacttatttatctaatgaaaagtcaaatgagaaaacgcaatttgaagtaacatacacacgaaatcaagatattttgaaaaacagacctggaatacattatgcacctccaattttagaaaaaaataaagatggtcaaagattaattgtcacttatgaagttgattggaaaaataaaacagttaaagtcgttgataaatattctgatgacaataaaccttataaagaagga |
27. | atgtatacacgtacagctacaacaagtgatagtcaaaaaaatattactcaaagcttacaatttaatttcttaactgaacctaattatgataaagaaacagtatttattaaagcaaaaggtacaattggtagtggtttgagaattttagacccaaatggttattggaatagtacattaagatggcctggatcttattcagtttcaattcaaaatgttgatgacaacaacaatacaaatgtgactgactttgcaccaaaaaatcaggatgaatcaagagaagttaaatatacgtatggttataaaacaggtggagatttttcgattaatcgtggaggcttaactggaaatattacaaaagagagtaattattcagagacgattagttatcaacaaccatcatatcgtacattacttgatcaatctacgtcacataaaggtgtaggttggaaagtagaagcacatttgataaataatatgggacatgaccatacgagacaattaactaatgatagtgataatagaactaaaagtgaaattttttctttaacacgaaatggaaatttatgggcgaaagataatttcacacctaaagacaaaatgcctgtaactgtgtctgaagggtttaatccagaatttttagctgttatgtcacatgataaaaaagacaaaggtaaatcacaatttgttgttcattataaaagatcaatggatgagtttaaaatagattggaatcgccatggtttctggggctattggtctggtgaaaaccatgtagataaaaaagaagaaaaattatcagcattatatgaagttgattggaagacacataatgtgaagtttgtaaaagtacttaatgataatgaaaagaaa |
28. | gtggtgaaatttatgaattatccaaatggtaaaccatatcgtaaaaatagtgctatagacggagggaaaaagaccgctgcctttagtaatattgagtatggtggacgtggtatgtcacttgaaaaagatatcgaacattcaaatacgttttatcttaaaagcgacattgcagttattcacaaaaagcctacgccagtacaaatagttaatgtcaactatcctaagcggagtaaagctgtgattaacgaagcttattttcgtacaccttcaacaactgattacaacggcgtttatcaaggttattatattgattttgaagcaaaggaaactaaaaacaagacgtcctttcctttaaataatattcatgaccatcaagtcgaacatatgaaaaatgcatatcaacaaaaaggtattgtgtttttaatgattcgttttaaaacgctagatgaagtttatcttttaccctattcaaaattcgaagtattttggaagagatataaagataatattaaaragtctataacagttgatgaaatacgaaaaaatggttaccatattccttatcagtatcaaccaagattagactatctaaaagcagttgataagttgatattagatgaaagtgaggaccgcgta |
29. | gtgaatacaacgaaagcagcattacatggtgatgtgaagttacaaaatgataaagatcatgctaagcaaacggttagtcaattagcacatctaaacaatgcacaaaaacatatggaagatacgttaattgatagttaaacaactagaacagcagttaagcaagatttgactgaagcacaagcattagatcaacttatggatgcattacaacaaagtattgctgacaaagatgcaacacgtgcgagcagtgcatatgtcaatgcagaaccgaataaaaaacaatcctatgatgaagcagttcaaaatgctgagtctatcattgcaggattaaataatccaactatcaataaaggtaatgtatcaagtgcgactcaagcagtaatatcatctaaaaatgcattagatggtgttgaacgattagctcaagataagcaaactgctggaaattctctaaatcatttagatcaattaacaccagctcaacaacaagcgctagaaaatcaaattaataatgcaacaactcgtggcgaagtagcacaaaaattaactgaagcacaagcacttaaccaagcaatggaagctttacgtaatagcattcaagatcaacagcaaacggaagcgggtagcaagtttatcaatgaagataaaccacaaaaagatgcttaccaagcagcagttcaaaatgcaaaagatttaattaatcaaactaacaatccaacgcttgataaagcacaagttgaacaattgacacaagctgttaaccaagctaaagataacctacacggtgatcaaaaacttgcagacgataaacaacatgcggttactgatttaaatcaattaaatggtttgaataatccgcaacgtcaagcacttgaaagccaaataaacaacgcagcaactcgtggcgaagtagcacaaaaattagctgaagcaaaagcgcttgatcaagcaatgcaagcattacgtaatagtattcaagatcaacaacaaacagaatctggtagcaagtttatcaatgaagataaaccgcaaaaagatgcttaccaagcagcagttcaaaatgcaaaagatttaattaaccaaacaggtaatccaacactcgacaaatcacaagtagaacaattgacacaagcagtaacaactgcaaaagataatctacatggtgatcaaaaacttgctcgtgatcaacaacaagcagtaacaactgtaaatgcattgccaaacttaaatcatgcacaacaacaagcattaactgatgctataaatgcagcgcctacaagaacagaggttgcacaacatgttcaaactgctactgaacttgatcacgcgatggaaacattgaaaaataaagttgatcaagtgaatacagataaggctcaaccaaattacactgaagcgtcaactgataaaaaagaagcagtagatcaagcgttacaagctgcagaaagcattacagatccaactaatggttcaaatgcgaataaagacgctgtagaccaagtattaactaagcttcaagaaaaagaaaatgagttaaatggtaatgagagagtcgctgaagctaaaacacaagcgaaacaaactattgaccaattaacacatttaaatgctgatcaaattgcaactgctaaacaaaacattgatcaagcgacgaaacttcaaccaattgctgaattagtagatcaagcaacgcaattgaatcaatctatggatcaattacaacaagcagttaatgaacatgctaacgttgagcaaactgtagattacacacaagcagattcagataaacaaaatgcttataaacaagctattgctgatgctgaaaatgtattgaaacaaaatgcgaataagcaacaagtggatcaagcacttcaaaatattttaaatgcaaaacaagcattaaatggtgatgaacgtgtagcacttgctaaaacaaatggtaaacatgacatcgaccaattgaatgcattaaacaatgctcaacaagatggatttaaaggtcgcatcgatcaatcaaacgatttaaatcaaatccaacaaattgtagatgaggctaaggcacttaatcgtgcaatggatcaattgtcacaagaaatcactgacaatgaaggacgcacgaaaggtagcacgaactatgtcaatgcagatacacaagtcaaacaagtatatgatgaaacggttgataaagcgaaacaagcacttgataaatcgactggtcaaaacttaactgcaaaacaagttatcaaattaaatgatgcagtcactgcagctaagaaagcattaaatggtgaagaaagacttaataatcgtaaagctgaagcattacaaagattggatcaattaacacatctaaacaatgctcaaagacaattagcaatccaacaaattaataatgctgaaacgctaaataaagcatctcgagcaattaatagagcaactaaattagataatgcaatgggtgcagtacaacaatatattgacgaacagcaccttggtgttatcagcagcacaaattacatcaatgcagatgacaatttgaaagcaaattatgataatgcaattgcgaatgcagcacatgagttagataaagtgcaaggtaatgcaattgcaaaagctgaagcagagcaattgaaacaaaatattatcgatgctcaaaatgcattaaatggagaccaaaaccttgcaaatgccaaagataaagcaaatgcgtttgttaattcgttaaatggattaaatcaacagcaacaagatcttgcacataaagcaattaacaatgccgatactgtatcagatgtaacagatattgttaataatcaaattgacttaaatgatgcaatggaaacattgaaacatttagttgacaatgaaattccaaatgcagagcaaactgtcaattaccaaaacgctgacgataatgctaaaacaaacttcgatgatgccaaacgtctagcaaatacattgctaaatagtgataacacaaatgtgaatgatatcaatggcgcaatccaagcagtcaatgatgcaatccataatcttaatggtgatcaacgactacaagatgctaaagacaaggcaattcaatctattaatcaagctttagctaataagctaaaagaaatcgaagcttcaaatgcgacggatcaagacaagcttattgcgaaaaataaagcagaagaattggcaaacagcatcatcaacaacattaataaagcaacaagtaatcaggctgtatctcaagttcaaacagcaggcaaccacgcgattgaacaagtgcatgccaatgaaataccaaaagcaaaaattgatgccaataaagacgttgataagcaagttcaagcattaattgacgaaattgatcgaaatccaaatctaacagataaggaaaaacaagcacttaaagatcgtattaatcaaatacttcaacaaggtcataacggcattaacaatgcgatgactaaagaagaaattgaacaagccaaagcacaacttgcgcaagcattacaagacatcaaagatttagtgaaagctaaagaagatgcgaaacaagatgttgataaacaagttcaagctttaattgacgaaatcgatcaaaatccaaatctaacagataaggaaaaacaagcacttaaagatcgtattaatcaaatacttcaacaaggtcatarcgacattamcaatgcgatgacaaaagaagcaattgaacaagcaaaagaacgtttagcgcaagcattgcaagacatcaaagatttagtgaaagctaaagaagatgcgaaaaatgatattgataaacgtgtacaagctttaattgacgaaatcgatcaaaatccaaatctaacagataaggaaaaacaagcacttaaagatcgaattaatcaaatacttcaacaaggtcataacgacattaacaatgcgctgactaaagaagaaattgagcaggcaaaagcacaacttgcacaagcattgcaagacatcaaagatttagtgaaagctaaagaagatgcgaaaaatgcaataaaagccttagctaatgcgaagcgtgatcaaatcaattcaaatccagatttaacacctgagcaaaaagcaaaagcgctcaaagaaattgacgaagctgaaaaacgagcactacaaaacgttgagaatgctcaaactatagatcaattaaatcgaggattaaacttaggtttagatgacattagaaatacacatgtatgggaggttgatgaacaacctgctgtaaatgaaatttttgaagcaacacctgagcaaatcctagttaatggtgaactcattgtacatcgtgatgacatcattacagaacaagatattcttgcacacataaacttaattgatcagctttcagcagaagtcatcgatacaccatcaactgcaacgatttctgatagcttaacagcaaaagttgaagttacattgcttgatggatcaaaagtgattgttaatgttcctgtaaaagttgtagaaaaagaattgtcagtagtcaaacaacaggcaattgaatcaatcgaaaatgcggcacaacaaaagattaatgaaatcaataatagtgtgacattaacactggaacaaaaagaagctgcaattgcagaagttaataagcttaaacaacaagcaattgatcatgttaacaatgcacctgatgttcattcagttgaagaaattcaacaacaagaacaagcgcatattgaacaatttaatccagaacaatttacgattgaacaagcaaaatcaaatgcaattaaatcgattgaagatgcaattcaacatatgattgatgaaatcaaagctcgtactgatctaacagataaagagaagcaagaagctattgctaagttaaatcaattaaaagaacaagcaattcaagcgattcaacgtgcgcaaagcatcgatgaaataagtgagcaattggaacaatttaaagctcaaatgaaagcagctaatccaacagcaaaagaactagctaaacgcaagcaagaagctattagtagaattaaagacttttcaaatgaaaaaataaatagtattcgaaatagtgaaattggcacagctgatgaaaaacaagcagcaatgaatcaaattaacgaaattgtgcttgaaacaattagagatattaataatgcgcatacattacagcaagttgaggctgcattgaacaatggtattgctcgaatttcagcagtacaaattgtaacatctgatcgtgctaaacaatcgtcaagtactggaaatgaatctaatagccatttaacaattggttatggaactgcaaatcatccatttaacagttcgactattggacataaaaagaaacttgatgaagatgatgacattgatccacttcatatgcgtcactttagtaataatttcggtaatgttattaaaaacgctattggtgtggtgggtatctctggtttactagctagtttctggttcttcattgccaaacgtcgtcgtaaagaagatgaagaggaagaattagaaataagagataataataaagattcaataaaagagactttagacgatacaaaacatttaccacttttatttgcgaaacgtcgcaga |
aaagaagatgaagaagatgttactgttgaagaaaaagattcgctaaataatggcgagtcactcgataaagttaaacatacgccgttcttcttaccaaaacgtcgtcgtaaagaagatgaagaagatgtggaagttacaaatgaaaacacagatgaaaaagtgttgaaagataacgaacattcaccactcttattcgcaaaacgacgcaaagataaagaggaagatgttgaaacaacaactagtattgaatctaaagatgaggacgttcctttattattggctaaaaagaaaaatcaaaaagataaccaatccaaagacaaaaagtcagcatcaaaaaatacttctaaaaaggtagcagctaaaaagaagaaaaagaaagctaagaaaaataaaaaa |
30. | atgaatcaggaagttaaaaacaaaatattttcaatcttaaaaattacgtttgctacagctttatttatttttgtagcaatcacattgtatcgggagttatctggtattaactttaaagatacgttggttgaatttagtaagattaaccgtatgtccttagtgttactatttattggtggtggggcatcgcttgttattctatcaatgtatgatgtgattttatctagagctttaaaaatggatatatccttaggcaaagttttaagagtaagttatatcatcaatgcattgaatgcgattgtaggtttcggtggctttattggtgcaggcgttagagcaatggtttataaaaactatacgcatgataaaaagaaattagttcactttatatccttaatacttatttcaatgttgacaggtttaagcttattatcattgctaattgtattccatgttttcgatgcatctttaatcttagataagattacatgggtaagatgggtattatatgtagtgtcatttttcttaccattattcattatttattcaatggttagaccacccgataaaaacaatcgttttgtaggattgtactgcactttagtgtcgtgtgttgaatggttagcagctgcagttgtattatatttctgtggtgtaattgttgacgctcatgtatcattcatgtcctttattgcaatatttatcattgctgcattatcaggtttagtcagctttattcctggtggtttcggcgctttcgatttagttgtattactaggatttaaaactttaggtgtccctgaggaaaaagtattattaatgctacttctatatcgttttgcgtactattttgtaccggtaattattgcattaattttatcatcatttgaatttggtacatcagctaagaagtacattgagggatctaaatactttattcctgctaaagatgttacgtcatttttaatgtcttatcaaaaggatattattgctaaaattccatcattatcattagcaattttagtattctttacaagtatgatcttttttgtaaataacttaacgattgtttacgatgctttatatgatggaaatcacttaacgtattatattctattggcaattcatactagtgcttgtttattacttttactgaatgtagttggtatttataagcaaagtagacgtgccattatctttgctatgatttcaattttattaatcacagtggcgacattcttcacttacgcttcatatattttaataacatggttagctattatttttgttctgcttattgtagctttccgtagagcacgtaggttgaaacgcccagtaagaatgagaaatatagttgcaatgcttttattcagtttatttattttatatgttaaccatatatttattggtggaacgttatatgcattagatatttatacgattgaaatgcatacatctgtattgcgctattacttctggcttacgattttaatcatcgctatcatcataggtatgattgcatggttgtttgattatcaatttagcaaagtacgtatttcttctaaaattgaagattgcgaggagattattaatcagtacggcggtaattatttgagtcacttgatatatagtggtgacaagcagtttttcactaatgaaaataaaacagcatttttaatgtatcgttataaagcaagttcattagtggttcttggagatccgttaggtgatgaaaatgcctttgatgaattgttagaagcattctataattacgctgagtatttaggctatgatgttatattctatcaagttacagatcaacacatgcctttatatcataatttcggtaaccaatttttcaaattaggtgaagaagcaattattgatttaacgcaattttcaacttcaggtaaaaaacgccgtggatttagagcgactttaaataaattcgatgaacttaatatttcgttcgaaattattgaaccaccgttttcaactgaatttataaatgaacttcaacatgtaagtgatttatggctagataatcgtcaggaaatgcatttctctgttggtgaatttaatgaagaatacttatctaaagcgccaattggtgtaatgcgaaatgaagaaaatgaagtaattgcattttgtagtttaatgccaacatactttaatgatgccatttcagtcgatttaattagatggttgccagagttagatttaccattaatggatggtctatacttgcatatgttactttggagtaaagaacaaggttatacaaaatttaatatgggtatggcaacgttatcgaaacttggtcaattgcattattcatatttaagagaacgacttgcaggccgtgtctttgaacatttcaacggtctatatcgtttccaaggattacgtcgttataaatctaaatataatccgaattgggaaccacgctttttagtttatcgtaaagataattcgctttgggaatcactttctaaagtaatgcgtgtaatacgtcacaaa |
31. | atggttgcattaacgcttgtaggttcagcagtcactgcacatcaagttcaagcagctgagacgacacaagatcaaactactaataaaaacgttttagatagtaataaagttaaagcaactactgaacaagcaaaagctgaggtaaaaaatccaacgcaaaacatttctggcactcaagtatatcaagaccctgctattgtccaaccaaaaacagcaaataacaaaacaggcaatgctcaagtaagtcaaaaagttgatactgcacaagtaaatggtgacactcgtgctaatcaatcagcgactacaaataatacgcagcctgttgcaaagtcaacaagcactacagcacctaaaactaacactaatgttacaaatgctggttatagtttagttgatgatgaagatgataattcagaaaatcaaattaatccagaattaattaaatcagctgctaaacctgcagctcttgaaacgcaatataaaaccgcagcacctaaagctgcaactacatcagcacctaaagctaaaactgaagcgacacctaaagtaactacttttagcgcttcagcacaaccaagatcagttgctgcaacaccaaaaacgagtttgccaaaatataaaccacaagtaaactcttcaattaacgattacattcgtaaaaataacttaaaagcacctaaaattgaagaagattatacatcttacttccctaaatacgcataccgtaacggcgtaggtcgtcctgaaggtatcgtagttcatgatacagctaatgatcgttcgacgataaatggtgaaattagttatatgaaaaataactatcaaaacgcattcgtacatgcatttgttgatggggatcgtataatcgaaacagcaccaacggattacttatcttggggtgtcggtgcagtcggtaaccctagattcatcaatgttgaaatcgtacacacacacgactatgcttcatttgcacgttcaatgaataactatgctgactatgcagctacacaattacaatattatggtttaaaaccagacagtgctgagtatgatggaaatggtacagtatggactcactacgctgtaagtaaatatttaggtggtactgaccatgccgatccacatggatatttaagaagtcataattatagttatgatcaattatatgacttaattaatgaaaaatatttaataaaaatgggtaaagtggcgccatggggtacgcaatctacaactacccctactacaccatcaaaaccaacaacaccgtcgaaaccatcaactggtaaattaacagttgctgcaaacaatggtgtcgcacaaatcaaaccaacaaatagtggtttatatactactgtatacgacaaaactggtaaagcaactaatgaagttcaaaaaacatttgctgtatctaaaacagctacattaggtaatcaaaaattctatcttgttcaagattacaattctggtaataaatttggttgggttaaagaaggcgatgtggtttacaacacagctaaatcacctgtaaatgtaaatcaatcatattcaatcaaacctggtacgaaactttatacagtaccttggggtacatctaaacaagttgctggtagtgtgtctggctctggaaaccaaacatttaaggcttcaaagcaacaacaaattgataaatcaatttatttatatggctctgtgaatggtaaatctggttgggtaagtaaagcatatttagttgatactgctaaacctacgcctacaccaacacctaagccatcaacacctacaacaaataataaattaacagtttcatcattaaacggtgttgctcaaattaatgctaaaaacaatggcttattcactacagtttatgacaaaactggtaagccaacgaaagaagttcaaaaaacatttgctgtaacaaaagaagcaagtttaggtggaaacaaattctacttagttaaagattacaatagtccaactttaattggttgggttaaacaaggtgacgttatttataacaatgcaaaatcacctgtaaatgtaatgcaaacatatacagtaaaaccaggcactaaattatattcagtaccttggggcacttataaacaagaagctggtgcagtttctggtacaggtaaccaaacttttaaagcgactaagcaacaacaaattgataaatctatctatttatttggaactgtaaatggtaaatctggttgggtaagtaaagcatatttagctgtacctgctgcacctaaaaaagcagtagcacaaccaaaaacagctgtaaaagcttatactgttactaaaccacaaacgactcaaacagttagcaagattgctcaagttaaaccaaacaacactggtattcgtgcttctgtttatgaaaaaacagcgaaaaacggtgcgaaatatgcagaccgtacgttctatgtaacaaaagagcgtgctcatggtaatgaaacgtatgtattattaaacaatacaagccataacatcccattaggttggttcaatgtaaaagacttaaatgttcaaaacttaggcaaagaagttaaaacgactcaaaaatatactgttaataaatcaaataacggcttatcaatggttccttggggtactaaaaaccaagtcattttaacaggcaataacattgctcaaggtacatttaatgcaacgaaacaagtatctgtaggcaaagatgtttatttatacggtactattaataaccgcactggttgggtaaatgcaaaagatttaactgcaccaactgctgtgaaaccaactacatcagctgccaaagattataactacacttatgtaattaaaaatggtaatggttattactatgtaacaccaaattctgatacagctaaatactcattaaaagcatttaatgaacaaccattcgcagttgttaaagaacaagtcattaatggacaaacttggtactatggtaaattatctaacggtaaattagcatggattaaatcaactgatttagctaaagaattaattaagtataatcaaacaggtatggcattaaaccaagttgctcaaatacaagctggtttacaatataaaccacaagtacaacgtgtaccaggtaagtggacaggtgctaactttaatgatgttaagcatgcaatggatacgaagcgtttagctcaagatccagcattaaaatatcaattcttacgcttagaccaaccacaaaatatttctattgataaaattaatcaattcttaaaaggtaaaggtgtattagaaaaccaaggtgctgcatttaacaaagctgctcaaatgtatggcattaatgaagtttatcttatctcacatgccctattagaaacaggtaacggtacttctcaattagcgaaaggtgcagatgtagtgaacaacaaagttgtaactaactcaaacacgaaataccataacgtatttggtattgctgcatatgataacgatcctttacgtgaaggtattaaatatgctaaacaagctggttgggacacagtatcaaaagcaatcgttggtggtgctaaattcatcggcaactcatatgtaaaagctggtcaaaatacactttacaaaatgagatggaatcctgcacatccaggaacacaccaatatgctacagatgtagattgggctaacatcaatgctaaaatcatcaaaggctactatgataaaattggcgaagtcggcaaatacttcgacatcccacaatataaa |
32. | atgaaaggtaaatttttaaaagttagttctttattcgttgcaactttgacaacagcgacacttgtgagttctccagcagcaaacgcgttatcttcaaaggctatggacaatcatccacaacaaacgcagtcaagcaaacagcaaacacctaagattcaaaaaggcggtaaccttaaaccattagaacaacgtgaacacgcaaatgttatattaccaaataacgatcgtcaccaaatcacagatacaacgaatggtcattatgcacccgtaacttatattcaagttgaagcacctactggtacatttattgcttccggtgtagttgtaggtaaagatactcttttaacraataaacacgtcgtagatgctacgcacggtgatcctcatgctttaaaagcattcccttctgcaattaaccaagacaattatccaaatggtggtttcactgctgaacaaatcactaaatattcagacgaaggtgatttagcaatagttaaattctcccctaatgagcaacacaaacatattggtgaagtagttaaaccagcaacaatgagtaataatgctgacactcaagttaaccaaaatattactgtaacaggatatcctggtgataaacctgtagcaacaatgtgggaaagtaaaggaaaaatcacttacctcaaaggcgaagctatgcaatatgatttaagtacaactggtggtaattcaggttcacctgtatttaatgaaaaaaatgaagtgatcggaattcattgggncggtgtaccaaatgaatttaatggtgcggtatttattaatgaaaatgtacgcaacttcttaaaacaaaatattgaagatatccattttgccacgatgaccaacctaataacccagataatcctgataaccctaacaatcctgataaccctaacaacccagatgaaccaaataaccctgacaaccctaacaaccctgataatccagacaatggcgatamcaataattcagacaatccagatgcagcttaat |
33. | gtgcaaaaaaaagtaattgcagctattattgggacaagcgcgattagcgctgttgcggcaactcaagcaaatgcggctacaactcacacagtaaaaccgggtgaatcagtgtgggcaatttcaaataagtatgggatttcgattgctaaattaaagtcattaaacaatttaacatctaatctaattttcccaaaccaagtactaaaagtatctggctcaagtaattctacgagtaatagtaggccgtccatcaacgaactcaggtggcggatcatactacacagtacaagaggcgactcattatcattaatcgcatcaaaatatggtacaacttaccaaaacattatgcgacttaatggtttaaataatttctttatttatccaggtcaaaaattaaaagtatcaggtactgctagctcaagtaacgctgcgagcaatagtagccgtccatcaacgaactcaggtggcggatcatactatacagtacaagcaggtgactcattgtcattaattgcatcaaaatatggtacaacttatcaaaaaattatgagcttaaatggcttaaataatttctttatatatccgggtcaaaaattgaaagtaactggtaatgcatctacgaactcaggatctgcaacaacgacaaatagaggttacaatacaccagtattcagtcaccaaaacttatatacatggggtcaatgtacatatcatgtatttaatcgtcgtgctgaaattggtaaaggtattagtacttattggtggaatgctaataactgggataacgcagcggcagcagatggttacactatcgacaatagacctactgtaggttctatcgctcaaacagatgtaggttactatggtcatgttatgtttgtagaacgtgtaaataacgatggtagtattttagtttcagaaatgaactattcagctgcaccaggtattttaacttacagaacggtaccagcttaccaagtaaataattatagatatattcac |
34. | atgaataataaaaagacagcaacaaatagaaaaggcatgataccaaatcgattaaacaaattttcgataagaaagtattctgtaggtactgcttcaattttagtagggacaacattgatttttgggttaagtggtcatgaagctaaagcggcagaacatacgaatggagaattaaatcaatcaaaaaatgaaacgacagccccaagtgagaataaaacaactaaaaaagttgatagtcgtcaactaaaagacaatacgcaaactgcaactgcagatcagcctaaagtgacaatgagtgatagtgcaacagttaaagaaactagtagtaacatgcaatcaccacaaaacgctacagctaatcaatctactacaaaaactagcaatgtaacaacaaatgataaatcatcaactacatatagtaatgaaactgataaaagtaatttaacacaagcaaaagatgtttcaactacacctaaaacaacgactattaaaccaagaactttaaatcgcatggcagtgaatactgttgcagctccacaacaaggaacaaatgttaatgataaagtacatttttcaaatattgacattgcgattgataaaggacatgttaatcagactactggtaaaactgaattttgggcaacttcaagtgatgttttaaaattaaaagcaaattacacaatcgatgattctgttaaagagggcgatacatttacttttaaatatggtcaatatttccgtccaggatcagtaagattaccttcacaaactcaaaatttatataatgcccaaggtaatattattgcaaaaggtatttatgatagtacaacaaacacaacaacatatacttttacgaactatgtagatcaatatacaaatgttagaggtagctttgaacaagttgcatttgcgaaacgtaaaaatgcaacaactgataaaacagcttataaaatggaagtaactttaggtaatgatacatatagcgaagaaatcattgtcgattatggtaataaaaaagcacaaccgcttatttcaagtacaaactatattaacaatgaagatttatcgcgtaatatgactgcatatgtaaatcaacctaaaaatacatatactaaacaaacgtttgttactaatttaactggatataaatttaatccaaatgcaaaaaacttcaaaatttacgaagtgacagatcaaaatcaatttgtggatagtttcacccctgatacttcaaaacttaaagatgttactgatcaattcgatgttatttatagtaatgataataaaacagctacagtcgatttaatgaaaggccaaacaagcagcaataaacaatacatcattcaacaagttgcttatccagataatagttcaacagataatggaaaaattgattatactttagacactgacaaaactaaatatagttggtcaaatagttattcaaatgtgaatggctcatcaactgctaatggcgaccaaaagaaatataatctaggtgactatgtatgggaagatacaaataaagatggtaaacaagatgccaatgaaaaagggattaaaggtgtttatgtcattcttaaagatagtaacggtaaagaattagatcgtacgacaacagatgaaaatggtaaatatcagttcactggtttaagcaatggaacttatagtgtagagttttcaacaccagccggttatacaccgacaactgcaaatgtaggtacagatgatgctgtagattctgatggactaactacaacaggtgtcattaaagacgctgacaacatgacattagatagtggattctacaaaacaccaaaatatagtttaggtgattatgtttggtacgacagtaataaagatggtaaacaagattcgactgaaaaaggaattaaaggtgttaaagttactttgcaaaacgaaaaaggcgaagtaattggtacaactgaaacagatgaaaatggtaaataccgctttgataatttagatagtggtaaatacaaagttatctttgaaaaacctgctggcttaactcaaacaggtacaaatacaactgaagatgataaagatgccgatggtggcgaagttgatgtaacaattacggatcatgatgatttcacacttgataatggctactacgaagaagaaacatcagatagcgactcagattctgacagcgattcagactcagatagcgactcagattcagatagcgactcagattcagacagcgattcagacagcgactcagactcagatagcgattcagattcagacagcgactcagactcagacagcgattcagactcggatagcgactcagactcagatagcgactcagattcggatagcgactcagactcagatagcgattcagattcagatagcgattcggactcagacagtgattcagattcagactcagatagcgactcagattctgacagcgattcagactcagacagcgactcagactcagacagtgattcagattcagacagcgactcagattcagatagcgactcagactcagatagcgactcagactcagatagcgactcagactcggatagcgattcagattcagacagcgactcagattcagatagcgattcggactcagacaacgactcagattcagatagcgattcagattcagatgcaggtaaacatactccggctaaaccaatgagtacggttaaagatcagcataaaacagctaaagcattaccagaaacaggtagtgaaaataataattcaaataatggcacattattcggtggattattcgcggcattaggatcattattgttattcggtcgtcgtaaaaaacaaaataaa |
35. | atggacataaattcagaagaatacaaacaagaggtacttatcaaagacgttgtcatgcttgctgctcgcatactattagaatctggtgcagaaggtacgcgtgtagaagataccatgacacgtattgcaaaaaaacttggttacagtgaaagtaacagctttgttacaaacactgtcatccagtttacgttacattcggaatcgtttcctagaatatttagaattacctctcgagatacaaacttaataaaaatttctcaagctaataaaatttcgcgtcaaattacaaacaatgaaatttctttagccgaagcaaaaacgcaacttgaaaaaatatatgttgctaagcgtgacagcagtcttccctttaaaggttttgctgcagcaatgattgcaatgagtttcttatatttacaaggtggtagattgattgatgttttaactgcgatattagcaggtagtctaggatacctagtcactgagattttagatcgtaagttacacgcacagtttatcccagaattcattggttcattagttattgggattatcgccgttattggacatacacttattccaacaggtgacttggcaactattatcattgcggcagtcatgcctattgttcctggtgtattaataacaaacgcaatacaagatttatttggtggacacatgttgatgttcacaacgaaatcattagaagcattggttactgcgtttggcatcggtgctggcgttggtagcgtattaattttagta |
36. | gtgattgctataatgaatgtaattatcgatgaaagaaaagagaatgctatgacatttaataaagtattattgagctggatagtcatattgattataacaactagcatatatctattttggcagttgggcgatatcaatgatgtatttaaccagtctattttaatcaatgttagattaccgagattattagaagcattgttgacaggtatgatattaactgttgcaggccttatatttcaaacagttttaaataatgcattggcagatagctttacattaggattggcaagcggcgctacatttggttcaggattagcattatttttaggtttaacaacgttatggattcctgtattttcaataacatttagtttgataacattaataactgtattagtcattacgtcggtattgagccaaggctatccagttagaatcttaatattaagtggtttaatgattggtgcgttattcaattcacttctatattttttgattttattaaaacctcgcaaattaaatacaattgccaattatctgtttggtggttttggtgatgcagaatactcaaatgtatctataatagcaatcacatttatcattgcattgtttggtatatttatcattcttaatcaactaaagttattgcaattaggagaactaaaaagtcagtcactaggcttaaatgttcaattgattacatatatcgcgttatgtatagcttctatgataacggcgataaatgtcgcatatgttggcatcattggattcattggtatggtgataccgcaactcattagaaaatggcagtggaaacaatcattaggaagacaattggctttaaatattgtaactggaggacaaataatggttatggcagattttattggtagccatatattgtcaccagtacaaataccggcaagtattatcattgcattaattggtataccagtgttattttacatgctaatatctcagtcgaaacggttacac |
37. | ttgaaaaaattagcatttgcaataacagcaacatctggtgcagctgcatttttaacgcatcatgatgcacaagcttctacacaacatacagtacaatctggtgaatcattatggagtattgctcaaaaatacaacacttcagtagagagtattaaacaaaataaccaattagataacaacttggtattccctggtcaagttatctcagtaggtggaagtgatgcacaaaatacgtcaaacacttctccacaagctggttcagcatcatctcatactgtacaagctggtgaatcattaaatatcattgctagcagatatggtgtttcagttgatcaattaatggcagccaataacttacgtggttatttaattatgcctaaccaaacattacaaattcctaatggtggatcaggtggtacaacaccaacagctacaacaggtagcaatggcaatgcatcatcttttaatcaccaaaatttatacactgctggtcaatgtacatggtacgtatttgaccgtcgtgctcaagctggtagtccaattagcacatattggtcagacgctaagtattgggctggtaacgcagctaatgatggttaccaagtaaacaacacaccatcagttggttcaattatgcaaagcacacctggtccatatggtcatgttgcttatgttgaacgtgtcaatggtgatggtagtatcttgatttctgaaatgaattacacatatggtccatacaatatgaactaccgtacaattccagcttcagaagtttctagctatgcattcatccat |
38. | atgccagattcaatcacaattatagatgaaaacaaagtgattgatgttgtattaattgcaggtagaattttacttgaatcaggtgctgaaacatatcgagttgaagatacaatgaaccgtatcgcacatagttatggtcttcataatacatatagttttgtcagttcaactgcaattattttttcattaaacgatcgaacaagtacaagattaattcgtgtacaagagcgtacaacagatttagagaaaatcgctttaacgaatagtctttcacgtaaaatatcaaataaagaactcacaattgatgaagctaaatctgaatttattcatttacagcatgcatcattacaatattcttttttaacgaatttctttgcagctgccattgcatgtggcttcttcctatttatgtttggtggtgtcgcatcagattgttggattgcagtcattgctggcggatccgcatttttaacattcagctttgtgcaacgctatatacaaattaaatttttctcagagtttgttgcagccgctgtggtcatatccattgcagccacatttactaaattaggcattgcaaccaatcaagatatcattactatagccagtgtcatgccacttgtccctggtacattaattaccaatgccattcgagatttattagcgggtgaattacttgcaggtatgtctcgcggtgttgaagctgcattaacagcattcgcaatcggtgctggtgtcgcaatcgttttattaatcatt |
39. | atgggatttttatcaaaaattcttgatggcaataataaagaaattaaacagttaggtaaacttgctgataaagtaatcgctttagaagaaaaaacggcaattttaactgatgaagaaattcgtaataaaacgaaacaattccaaacagaattagctgacattgataatgtcaaaaagcaaaatgattatttagataaaattttaccagaagcatatgcacttgttagagaaggctctaaacgtgtatccaatatgacaccatataaagttcaaattatgggtggtattgcaattcataaaggcgacaccgctgagatgagaacaggtgaaggtaaaacattaacagcgacaatgccaacatacttaaatgcattagctggtagaggtgttcacgttattacagtcaatgaatacttatcaagtgttcaaagtgaagaaatggctgagttatataacttcttaggtttgactgtcggattaaacttaaacagtaagacgacagaagaaaaacgtgaaccatacgcacaagacattacttacagtactaataatgagctaggttttgattacttacgagataacatggtgaattattctgaagatagagtaatgcgttcattacactttgcaatcattgatgaggttgactcaattttaatcgacgaggcacgtacgccattaattatttctggtgaagctgaaaagtcaacgtcactttatacacaagcaaatgtttttgcgaaaatgttaaaacaggacgaagattataaatacgatgaaaaaacgaaagctgtacatttaacagaacaaggtgcggataaagctgaacgtatgttcaaagttgaaaacttatacgatgtacaaaatgttgatgttattagtcatatcaacacagctttacgtgcgcacgttacattacaacgtgacgtagactatatggttattgatggcgaagtattaattgtcgatcaatttacaggacgtacaatgccaggccgccgtttctcggaaggtttacaccaagctattgaagcgaaggaaggcgttcaaattcaaaatgaatctaaaactatggcgtctattacattccaaaactatttcagaatgtacaataaacttgcgggtatgacaggtacagctaaaactgaagaagaagaatttagaaatatttataacatgacagtaactcaaattccgacaaataaacctgtgcaacgtaacgataagtctgatttaatttacattagccaaaaaggtaaatttgatgcagtagtagaagatgttgttgaaaaacacaaggcagggcaaccagtgctattaggcactgttgcagttgagacttctgaatatatttcaaatttacttaaaaaacgtggtatccgccacgatgtgttaaatgcgaaaaatcatgaacgtgaagctgaaattgttgcaggcgctggacaaaaaggtgccgttactattgccactaacatggctggtcgtggtacagatatcaaattaggtgaaggcgtagaggaattaggcggtttagcagtaataggtacagagcgacatgaatctcgtcgtattgatgaccagttacgtggtcgttctggacgtcaaggtgataaaggggatagtcgcttctatttatcattacaagatgaattaatgattcgttttggttctgaacgtttacagaaaatgatgagccgactaggtttagatgactctacaccaattgaatcaaaaatggtatcaagagctgtagaatcagcacaaaaacgtgtagaaggtaataacttcgacgcgcgtaaacgtatcttagaatacgatgaagtattacgtaaacaacgtgaaattatctataacgaaagaaatagtattattgatgaagaagacagctctcaagttgtagatgcaatgctacgttcaacgttacaacgtagtatcaattactatattaatacagcagatgacgagcctgaatatcaaccattcatcgactacattaatgacatcttcttacaagaaggtgacattacagaggatgatatcaaaggtaaagatgctgaagatattttcgaagtcgtttgggctaagattgaagcagcatatcaaagtcaaaaagatatcttagaagaacaaatgaatgagtttgagcgtatgattttacttcgttctattgatagccattggactgatcatatcgacacaatggatcaattacgtcaaggtattcacttacgttcttatgcacaacaaaatccattacgtgactatcaaaatgaaggtcatgaattatttgatatcatgatgcaaaatattgaagaagatacttgtaaattcattttaaaatctgtagtacaagttgaagataatattgaacgtgaaaaaacaacagagtttggtgaagcgaagcacgtttcagctgaagatggtaaagaaaaagtgaaaccgaaaccaatcgttaaaggcgatcaagttggtcgtaacgatgattgtccatgtggtagtggtaaaaaattcaaaaattgccatggaaaa |
40. | gtgagggagagtatgtcgaatcaaaattacgactacaataaaaatgaagatggaagtaagaagaaaatgagtacaacagcgaaagtagttagcattgcgacggtattgctattactcggaggattagtatttgcaatttttgcatatgtagatcattcgaataaagctaaagaacgtatgttgaacgaacaaaagcaggaacaaaaagaaaagcgtcaaaaagaaaatgcagaaaaagagagaaagaaaaagcaacaagaggaaaaagagcagaatgagctagattcacaagcaaaccaatatcagcaattgccacagcagaatcaatatcaatatgtgccacctcagcaacaagcacctacaaagcaacgtcctgctaaagaagagaatgatgataaagcatcaaaggatgagtcgaaagataaggatgacaaagcatctcaagataaatcagatgataatcagaagaaaactgatgataataaacaaccagctcagcctaaaccacagccgcaacaaccaacaccaaagccaaataataatcaacaaaacaatcaatcaaatcagcaagcaaaaccacaagcaccacaacaaaatagccaatcaacaacaaataaacaaaataatgctaatgataag |
41. | atgaatatgaagaaaaaagaaaaacacgcaattcggaaaaaatcgattggcgtggcttcagtgcttgtaggtacgttaatcggttttggactactcagcagtaaagaagcagatgcaagtgaaaatagtgttacgcaatctgatagcgcaagtaacgaaagcaaaagtaatgattcaagtagcgttagtgctgcacctaaaacagacgacacaaacgtgagtgatactaaaacatcgtcaaacactaataatggcgaaacgagtgtggcgcaaaatccagcacaacaggaaacgacacaatcatcatcaacaaatgcaactacggaagaaacgccggtaactggtgaagctactactacgacaacgaatcaagctaatacaccggcaacaactcaatcaagcaatacaaatgcggaggaattagtgaatcaaacaagtaatgaaacgacttctaatgatactaatacagtatcatctgtaaattcacctcaaaattctacaaatgcggaaaatgtttcaacaacgcaagatacttcaactgaagcaacaccttcaaacaatgaatcagctccacagagtacagatgcaagtaataaagatgtagttaatcaagcggttaatacaagtgcgcctagaatgagagcatttagtttagcggcagtagctgcagatgcaccggcagctggcacagatattacgaatcagttgacgaatgtgacagttggtattgactctggtacgactgtgtatccgcaccaagcaggttatgtcaaactgaattatggtttttcagtgcctaattctgctgttaaaggtgacacattcaaaataactgtacctaaagaattaaacttaaatggtgtaacttcaactgctaaagtgccaccaattatggctggagatcaagtattggcaaatggtgtaatcgatagtgatggtaatgttatttatacatttacagactatgtaaatactaaagatgatgtaaaagcaactttgaccatgcccgcttatattgaccctgaaaatgttaaaaagacaggtaatgtgacattggctactggcataggtagtacaacagcaaacaaaacagtattagtagattatgaaaaatatggtaagttttataacttatctattaaaggtacaattgaccaaatcgataaaacaaataatacgtatcgtcagacaatttatgtcaatccaagtggagataacgttattgcgccggttttaacaggtaatttaaaaccaaatacggatagtaatgcattaatagatcagcaaaatacaagtattaaagtatataaagtagataatgcagctgatttatctgaaagttactttgtgaatccagaaaactttgaggatgtcactaatagtgtgaatattacattcccaaatccaaatcaatataaagtagagtttaatacgcctgatgatcaaattacaacaccgtatatagtagttgttaatggtcatattgatccgaatagcaaaggtgatttagctttacgttcaactttatatgggtataactcgaatataatttggcgctctatgtcatgggacaacgaagtagcatttaataacggatcaggttctggtgacggtatcgataaaccagttgttcctgaacaacctgatgagcctggtgaaattgaaccaattccagaggattcagattctgacccaggttcagattctggcagcgattctaattcagatagcggttcagattcgggtagtgattctacatcagatagtggttcagattcagcgagtgattcagattcagcaagtgattcagactcagcgagtgattcagattcagcaagcgattccgactcagcgagcgattccgactcagacaatgactcggattcagatagcgattctgactcagacagtgactcagattccgacagtgactcagattcagatagcgattctgactcagacagtgactcagattcagatagcgattcagattcagatagcgattcagattccgacagtgattccgactcagacagcgattctgactccgacagtgattccgactcagacagcgattcagattccgacagtgattccgactcagatagcgattccgactcagatagcgactcagattcagacagcgattcagattcagacagcgattcagattcagatagcgattcagattccgacagtgactcagattccgacagtgactcggattcagatagcgattcagattccgacagtgactcagattccgacagtgactcagactcagacagtgattcggattcagcgagtgattcggattcagatagtgattccgactccgacagtgactcggattcagatagcgactcagactcggatagcgactcggattcagatagcgattcggactcagatagcgattcagaatcagacagcgattcagaatcagacagcgattcagattcagacagcgactcagacagtgactcagattcagatagtgactcggattcagcgagtgattcagactcaggtagtgactccgattcatcaagtgattccgactcagaaagtgattcaaatagcgattccgagtcaggttctaacaataatgtagttccgcctaattcacctaaaaatggtactaatgcttctaataaaaatgaggctaaagatagtaaagaaccattaccagatacaggttctgaagatgaagcaaatacgtcactaatttggggattattagcatcaataggttcattactacttttcagaagaaaaaaagaaaataaagataagaaa |
42. | atgaattcaaatcacgctaaagcatcagtgacagagagtgttgacaaaaaatttgtagttccagaatcaggaattaataaaattattccagcttacgatgaatttaagaattcgccaaaagtaaatgttagtaatttaactgacaataaaaactttgtagcttctgaagataaattgaataagattgcagattcatcggcagctagtaaaattgtagataaaaactttgtcgtaccagaatcaaagttaggaaacattgtgccagagtacaaagaaatcaataatcgcgtgaatgtagcaacaaacaatccagcttcacaacaagttgataagcattttgttgctaaaggcccagaagtaaatagatttattacgcaaaacaaagtaaaccaccacttcattactacgcaaacccactacaagaaagttattacttcatacaaatcaacacatgtacataaacatgtaaatcatgcaaaggattctattaataaacactttattgttaaaccatcagaatcgcctagatatacacatccatctcaatctttaattatcaagcatcattttgcagttcctggatatcacgcgcataaatttgttacaccagggcatgctagcattaaaattaatcacttttgtgttgtgccacaaataaatagtttcaaggtaattccaccatatggtcacaattcacatcgtatgcatgtaccaagtttccaaaataacacaacagcaacacatcaaaatgctaaagtaaataaagcatatgactataaatacttctattcttataaagtagttaaaggtgtgaagaaatatttctcattttcacaatcaaatggttataaaattgggaaaccatcattaaatatcaaaaatgtaaattatcaatatgctgttccaagttatagccctacacactacgttcctgaatttaagggtagcttaccagcaccacgagta |
43. | ttggagcatacaattatgaaaatgagaacaattgctaaaaccagtttagcactagggcttttaacaacaggcgcaattacagtaacgacgcaatcggtcaaagcagaaaaaatacaatcaactaaagttgacaaagtaccaacgcttaaagcagagcgattagcaatgataaacataacagcaggtgcaaattcagcgacaacacaagcagctaacacaagacaagaacgcacgcctaaactcgaaaaggcaccaaatactaatgaggaaaaaacctcagcttccaaaatagaaaaaatatcacaacctaaacaagaagagcagaaaacgcttaatatatcagcaacgccagcgcctaaacaagaacaatcacaaacgacaaccgaatccacaacgccgaaaactaaagtgacaacacctccatcaacaaacacgccacaaccaatgcaatctactaaatcagacacaccacaatctccaaccataaaacaagcacaaacagatatgactcctaaatatgaagatttaagagcgtattatacaaaaccgagttttgaatttgaaaagcagtttggatttatgctcaaaccatggacgacggttaggtttatgaatgttattccaaataggttcatctataaaatagctttagttggaaaagatgagaaaaaatataaagatggaccttacgataatatcgatgtatttatcgttttagaagacaataaatatcaattgaaaaaatattctgtcggtggcatcacgaagactaatagtaaaaaagttaatcacaaagtagaattaagcattactaaaaaagataatcaaggtatgatttcacgcgatgtttcagaatacatgattactaaggaagagatttccttgaaagagcttgattttaaattgagaaaacaacttattgaaaaacataatctttacggtaacatgggttcaggaacaatcgttattaaaatgaaaaacggtgggaaatatacgtttgaattacacaaaaaactgcaagagcatcgtatggcaggcactaatattgataacattgaagtgaatataaaa |
44. | atgacaacaattaaaacatcaaacttaggattcccaagattaggtagaaaaagagaatggaaaaaagccatcgaaagttattgggcaaagaagatttctaaagaagaattagatcaaacattaactgatctacataaagaaaatttattattaacaaaagtactatacttagatagcatcccagttggtgatttctctttatatgaccatatattagatacgtcattattattcaacatcatccctgaacgtttccaaggaagaactattgatgatgatttattatttgatattgctcgcggtaataaagaccatgttgcaagtgcacttataaaatggtttaacactaactatcattacatcgtacctgaatgggacaatgttgagcctaaagtgagtcgcaatgtattattagatcgctttaaatatgcccaatctttaaacgttaacgctcaccctgtcattgttggtccgattacttttgttaaattatcaaaaggcggtcaccaaacttttgaagaaaaagttaaaacgttattaccactttataaagaagtgtttgaatcattaattgatgcaggtgctgagtacattcaagttgatgagccaatcttagttacagacgacagcgaaagctatgaaaatattacacgtgaagcttatgactatttcgaaaaagctggtgttgctaaaaaattagtcattcaaacatactttgaacgtgcacatcttaaattcttaagttctttacctgttggtggtataggtttagactttgtccatgataatggctataaccttaaacaaattgaagctggagattttgataaatcaaaaacattatacgctggaattattgatggtcgtaatgtatgggcaagtgacattgaagctaaaaaagtcttaatcgataaattgttagcacacactaatgaacttgtcattcaaccatcatcttcattattacatgttccagtatctttagatgatgaaacattagatacaagtgttggagaaggcttaagctttgcaactgaaaaattagacgaattagatgcattgcgtcgcctatttaatcaaaacgatagtgttaaatatgataaattaaaagcacgttatgagcgtttccaaaatcaatcattcaaaaacttagattatgatttcgaaagcgtgcgtacttcaagacaatcaccattcgcgcaacgtattgaacaacaacaaaaacgtttgaacttaccggatttaccaacaacaactattggatcattcccacaaagccgagaagttcgaaaataccgtgcagattggaagaacaaacgcattacagacgaagcatatgaaacattcttaaaaaatgaaattgctcgatggattaaaattcaagaagacattggcttagatgtattagttcacggtgaatttgaacgtaatgacatggttgaattcttcggagaaaaattacaaggtttcttagtaactaaattcggttgggtgcaatcatatggttcacgtgccgtaaaaccaccaatcatttatggtgatgtaaaatggacagcgcctttaactgttgatgaaacagtttatgcacaaagcttaacagataaaccagttaaaggtatgttaactggacctgtaacaattctaaactggtcatttgaacgtgttgatttaccacgtaaagtcgttcaagatcaaattgctttagcaatcaacgaagaagtattagcacttgaagctgcaggaatcaaagttatccaagttgacgaacctgcattacgtgaaggcttaccattacgctctgaatatcacgaacaatatcttaaagatgctgttttatcatttaaacttgcaacgtcttcagttcgtgatgaaactcaaatccatacacatatgtgttattctcaattcggtcaaatcattcatgctattcatgacttagatgctgatgttatttcaattgaaacatctcgtagccatggtgatttaattaaagactttgaagatattaattatgatttaggtattggtctaggtgtatatgatattcatagtccacgtattccaacaaaagaagaaattactacagcaatcaatcgttcactacaacaaatcgaccgctcattattctgggtaaaccctgactgtggtttaaaaacgcgaaaagaagaagaagttaaagatgcattgactgtgcttgtgaatgctgttaaagctaaacgccaagaa |
45. | atgagcgacacatataaaagctacctagtagcagtactatgcttcacagtcttagcaattgtacttatgccgtttctatacttcactacagcatagtcaattgcgggattcgcaagtatcgcaacattcatattttataaagaatacttttatgaagaa |
46. | atgttaagaggacaagaagaaagaaagtatagtattagaaagtattcaataggcgtggtgtcagtgttagcggctacaatgtttgttgtgtcatcacatgaagcacaagcctcggaaaaaacatcaactaatgcagcggcacaaaaagaaacactaaatcaaccgggagaacaagggaatgcgataacgtcacatcaaatgcagtcaggaaagcaattagacgatatgcataaagagaatggtaaaagtggaacagtgacagaaggtaaagatacgcttcaatcatcgaagcatcaatcaacacaaaatagtaaaacaatcagaacgcaaaatgataatcaagtaaagcaagattctgaacgacaaggttctaaacagtcacaccaaaataatgcgactaataatactgaacgtcaaaatgatcaggttcaaaatacccatcatgctgaacgtaatggatcacaatcgacaacgtcacaatcgaatgatgttgataaatcacaaccatccattccggcacaaaaggtaatacccaatcatgataaagcagcaccaacttcaactacacccccgtctaatgataaaactgcacctaaatcaacaaaagcacaagatgcaaccacggacaaacatccaaatcaacaagatacacatcaacctgcgcatcaaatcatagatgcaaagcaagatgatactgttcgccaaagtgaacagaaaccacaagttggcgatttaagtaaacatatcgatggtcaaaattccccagagaaaccgacagataaaaatactgataataaacaactaatcaaagatgcgcttcaagcgcctaaaacacgttcgactacaaatgcagcagcagatgctaaaaaggttcgaccacttaaagcgaatcaagtacaaccacttaacaaatatccagttgtttttgtacatggatttttaggattagtaggcgataatgcacctgctttatatccaaattattggggtggaaataaatttaaagttatcgaagaattgagaaagcaaggctataatgtacatcaagcaagtgtaagtgcatttggtagtaactatgatcgcgctgtagaactttattattacattaaaggtggtcgcgtagattatggcgcagcacatgcagctaaatacggacatgagcgctatggtaagacttataaaggaatcatgcctaattgggaacctggtaaaaaggtacatcttgtagggcatagtatgggtggtcaaacaattcgtttaatggaagagtttttaagaaatggtaacaaagaagaaattgcctatcataaagcgcatggtggagaaatatcaccattattcactggtggtcataacaatatggttgcatcaatcacaacattagcaacaccacataatggttcacaagcagctgataagtttggaaatacagaagctgttagaaaaatcatgttcgctttaaatcgatttatgggtaacaagtattcgaatatcgatttaggattaacgcaatggggctttaaacaattaccaaatgagagttacattgactatataaaacgcgttagtaaaagcaaaatttggacatcagacgacaatgctgcctatgatttaacgttagatggctctgcaaaattgaacaacatgacaagtatgaatcctaatattacgtatacgacttatacaggtgtatcatctcatactggtccattaggttatgaaaatcctgatttaggtacatttttcttaatggctacaacgagtagaattattggtcatgatgcaagagaagaatggcgtaaaaatgatggtgtcgtaccagtgatttcgtcattacatccgtccaatcaaccatttgttaatgttacgaatgatgaacctgccacacgcagaggtatctggcaagttaaaccaatcatacaaggatgggat |
47. | atgattcatctcattaaggggaagatgcatcatacagttttgtgtattcatttaaacaaaggggttgctttaatgaatcaatatcattctaatgcacaacaaccaagtgcatggcgtttttttgtctatagtttagtgggcatactatgtttctttattccttttacgattaatggtaacaacactattttcgtcgatcatgttcatctagccattcgctcaatcataggtccacttatgccctatgttgcactgattatgattttaattggtacagcgttaccaatagtgagacgtacttttatgacttcaatcacaaacttggtcattacattatttaaagttgcaggtgcaatgatcggtataatgtatgtatttaaaatcggtccatcaatactatttaaagctaactatggtccgtttttgtttgaaaaattaatgatgccattaagtatcttaattccagtaggtgcaattgcgctttctttattagtgggctatggcttattagaatttgtcggtgtttatatggagcctattatgagacctatttttaaaacaccaggaaaatccgctgtcgatgcagtggcttcgtttgtcggcagttattccttaggattattgattactaatcgtgtctataagcaagggatgtacaacaaacgagaagccacgattattgcgactggcttttcaacagtttcagcaacttttatgattatcgttgctaaaactttaggattaatgccgcattggaatttatacttttggataactttagtcatcacatttgtcgtgactgcaattactgcatggctaccgccaatcagcaatgaatcaacagaatattataacggacaagcaggagaacaagaagttgctattgaaggaagcagactgaaaactgcatatgcagaggcgatgaaacaaaatgcattaacaccatctctcgtgaagaacgtttgggacaatttgaaagacggtttagaaatgactgttggtattttaccttctatattatcgattggttttttaggactgattgtagcgaactatacaccattcattgattggcttggctatatcttctatccatttatttatattttcccaattgctgatcaggctttactagcaaaagcgtcagcgatttctattgtagagatgtttctaccatctttgttagtaactaaagctgcaatgagtactaaatttgtcgtcggtgtagtaagcgtatcagccattatctttttctcagcattagtgccatgtatactagcaactgaaattaaaatacctgtctggaaactcatcatcatttggtttttacgcgtggcgttgtcgctattaatcaccatccccgtcgctttacttatttttgga |
48. | atggttattatgaagaaaacaattttactgacgatgacaactcttactttatttagtatgtcgcctaactcggctcaagcatatacgaatgatagcaaaacattagaagaagcaaagaaagcacacccaaacgcacagttcaaagtgaataaagacaccggcgcgtatacttatacatatgacaaaaacaacacgccaaacaacaatcatcaaaaccagtcacgtacaaacgacaatcatcaacacgcaaatcaacgtgatcttaacaacaatcagtaccattcttcattaagtggtcagtatacgcacattaatgacgcaattgattcacacacaccgcctcaaacgtcaccaagcaatcctttgacaccagcaataccgaatgtcgaagacaatgacgatgaattaaataacgctttttcaaaagataacaaagggcttattacaggcatcgatttagacgaattgtatgacgaattacaaatcgccgaatttaatgacaaagcaaagaccgctgacggtaaacctttagcattaggtaacggtaaaatcattgatcagcctcttatcacaagtaagaacaacttatatactgctggacaatgtacatggtatgtctttgataaacgtgccaaagatggacacacgattagtacattttggggagatgctaaaaactgggcaggccaagcttcaagcaatggcttcaaagtagatagacacccaacacgaggatcaattttacaaacagtaaatggtccatttggtcatgtagcctacgttgaaaaagttaatattgatggaagtattctaatttcagaaatgaactggattggtgaatatatcgtttcatcaagaaccatctctgcttcagaagtttcatcatataattacatccat |
49. | ttggaggtatcgtcaatgaagccttatatacaacttgttgtgttcaagcaatggttacaatacatcttgctcgtaacaaccattgtcatcgcactcgtacttattggtatcggttaccgtgtagcacatgacaacttcaaaataccgattaccattcaagatttagaccaaaccactgcatcaaaatcattcgtcaataaaattaaacaatctgactatgtaactattaaaaaagtcgatgaagatgaaagctatattgaagatgatgttactaaaaaggaagctattttaagtatgcaaattcctaaaggtttctctcaaaaattaaaagagaaccgtttaaaagaaacgatacagttatatggtagagatgactttataggtggtattgctgtagaaattgttagtagttcattatatgagcagcaaattcctaacattatttatgaacaccttgaggatatgaaacagcatcaatccatcgatgctatcaacaagtcctatcataaacatacacctgaatctaaaatcaaatttgtgtcgcttactaaacaagcacaacactctatttcaattagcttaatctttgcggtgattttatttgttagcgctgttcaagtagtacttcattatcgtttaaaccaacaagcagcattgcaacgattatcacaatatcatttaagccgtttcaaactatatagtacttatgtaatgacacatacgattttgttattgttggtactattggcagttagtctatatttgtctcaaccactcagcttaatattttacttaaaatcactgttacttatattgatttatgagataggtatcgtctttatcttattccatattcaaacaataagtcatcgattattcatgacatttatatatgcacttgctatgggtatcgtatacttgattattttcatg |
50. | atgattgaggtgacagagatgaacttttttgatatccataagattccgaacaaaggcattccattatcggtacaacgtaaattatggcttagaaacttcatgcaagctttcttcgtagtgttctttgtttatatggctatgtatttaattcgaaacaactttaaggcggcacaaccgtttttaaaagaggaaattggattatctacattagaacttggttatatcggattagcatttagtatcacgtacggtttaggaaaaacattacttggatattttgtcgatggacgtaacacaaaacgtattatctcgttcttacttatcttatctgcgattacagttttaattatgggatttgttttaagttactttggttctgtaatgggattattaattgtactttggggacttaacggggtgttccaatcagttggtggacctgcaagttattcaacgatttcaagatgggcgccaagaacgaaacgtggccgatacttaggattctggaatacatcacataatatcggtggtgccatagcaggtggtgttgcactttggggtgctaatgtattcttccatggaaatgttatagggatgttcattttcccatcggtgattgcattacttattggtatcgcaacattatttatcggaaaagatgatccggaagaattaggatggaatcgtgctgaagaaatttgggaagagccggtcgataaagaaaatattgattctcaaggtatgacgaaatgggagatctttaaaaaatatatcctgggaaatcctgttatatggattctatgtgtttcaaacgtctttgtatacattgtacgaatcggtattgataactgggcaccgttatatgtgtcagagcatttacactttagtaaaggcgatgcagttaatacgatattctactttgaaattggtgcattagttgcaagtttattatggggctacgtatcagacttattaaaaggtcgtcgtgcaattgtagctattggctgtatgtttatgattacatttgttgtcttattctacacaaatgctacaagtgtcatgatggttaacatttcattgtttgcattaggtgcgttaatctttggtccgcaattattaattggtgtatcattgactggttttgttcctaaaaatgccatcagtgtagcaaacggaatgacaggttcattcgcgtatctattcggtgactcaatggcgaaagttggtttggcggctattgctgatccaacacgtaacggtttaaacatctttggatatacattaagtggatggacagatgttttcatcgtcttctatgttgcattattcctaggcatgattctattaggaatcgttgctttctatgaagaaaagaaaattagaagtttaaaaatt |
51. | atgacaaagaagaaaaacatattaaaagcaatcggtatttacagttttatagcgatgatgtttgtcatcattttatatccactactgtggacatttggcatttcccttaatccaggtacgaacttgtatggtgccaaaatgataccagacaatgcaacatttaaaaattatgcattcttactattcgatgacagtagtcaatacctgacttggtataaaaatacgcttatcgtagcatctgcaaatgcactgtttagtgtgatatttgtcacgttaacagcatatgctttttctagatatcgctttgttggtcgtaaatacgggctgattacatttttgattttacaaatgttccctgtattaatggcaatggtcgcaatctatattttgctaaatacaattggattattagattctttatttggactaacactggtatatattggtggatcaataccgatgaatgcctttttagtgaaaggttacttcgatacgattccaaaagaacttgatgaatctgccaaaattgatggtgcagggcatatgcgtattttcttacaaattatgcttccattagctaagccgattttagcagttgttgctttgttcaattttatggggccatttatggactttatattacctaaaatactattaagaagtcctgaaaaattcacattagcagttggattgttcaactttattaatgataagtatgcaaataatttcacagtgtttgcagcaggggcaattatgattgcagtacctatagcaatcgtattcttgttcttgcaacgctatttagtatcaggtttaacaacaggtgcgacaaaaggt |
52. | gtgatggaaaatagtacgaccgaagcgcgtaatgaagcgacgatgcatcttgatgaaatgactgtggaagaggctttaattacgatgaataaagaagatcagcaagtcccgttagcagttcgaaaggcaataccacaattgacaaaagtaattaaaaaaacaattgcacagtataaaaagggtggacgattgatttatatcggtgcaggtacaagtggaaggttgggtgtcttagatgcagcggagtgtgtacctacattcaatactgaccctcatgaaattataggtattattgctggtggacaacatgctatgacgatggctgtagaaggtgcggaagatcacaaaaaattagcggaagaagatttgaaaaatatagatttaacatcaaaagatgtcgttataggaattgccgcgagtggcaaaacgccatatgttataggcggtttaacatttgctaacacaatcggtgctacaacagtatctatttcatgcaatgaacatgcagttataagtgaaattgcgcagtatccagtagaagttaaagttggtccagaagtattaactggttcaacacgtttaaagtctggtacagcacaaaagttaattttaaatatgatttcaaccatcacaatggttggtgtcggaaaagtttacgataacctcatgattgatgttaaagcaaccaatcaaaaactgatcgaccgttcagtgcgtattattcaagaaatatgtgctatcacatatgatggggcaatggcgttatatcaggtatctgagcatgatgtgaaagttgcgacagttatgggtatgtgtggcatttctaaggaagaagcaacaagacggttattaaacaatggtgacattgttaaacgagcaatcagagatagacaacct |
53. | ttgcaatacataattcgttatattatgatgactttacaaatacatacagggggtattaatttgaaaaagaaaaacatttattcaattcgtaaactaggtgtaggtattgcatctgtaactttaggtacattacttatatctggtggcgtaacacctgctgcaaatgctgcgcaacacgatgaagctcaacaaaatgctttttatcaagtcttaaatatgcctaacttaaatgctgatcaacgcaatggttttatccaaagccttaaagatgatccaagccaaagtgctaacgttttaggtgaagctcaaaaacttaatgactctcaagctccaaaagctgatgcgcaacaaaataacttcaacaaagatcaacaaagcgccttctatgaaatcttgaacatgcctaacttaaacgaagcgcaacgtaacggcttcattcaaagtcttaaagacgacccaagccaaagcactaacgttttaggtgaagctaaaaaattaaacgaatctcaagcaccgaaagctgataacaatttcaacaaagaacaacaaaatgctttctatgaaatcttgaatatgcctaacttaaacgaagaacaacgcaatggtttcatccaaagcttaaaagatgacccaagccaaagtgctaacctattgtcagaagctaaaaagttaaatgaatctcaagcaccgaaagcggataacaaattcaacaaagaacaacaaaatgctttctatgaaatcttacatttacctaacttaaacgaagaacaacgcaatggtttcatccaaagcctaaaagatgacccaagccaaagcgctaaccttttagcagaagctaaaaagctaaatgatgctcaagcaccaaaagctgacaacaaattcaacaaagaacaacaaaatgctttctatgaaattttacatttacctaacttaactgaagaacaacgtaacggcttcatccaaagccttaaagacgatccttcagtgagcaaagaaattttagcagaagctaaaaagctaaacgatgctcaagcaccaaaagaggaagacaataacaagcctggcaaagaagacaataacaagcctggcaaagaagacaacaacaagcctggtaaagaagacaacaacaagcctggcaaagaagacggcaacaagcctggtaaagaagacaacaaaaaacctggtaaagaagatggcaacaagcctggtaaagaagacaacaaaaaacctggtaaagaagacggcaacaagcctggcaaagaagatggcaacaaacctggtaaagaagatggtaacggagtacatgtcgttaaacctggtgatacagtaaatgacattgcaaaagcaaacggcactactgctgacaaaattgctgcagataacaaattagctgataaaaacatgatcaaacctggtcaagaacttgttgttgataagaagcaaccagcaaaccatgcagatgctaacaaagctcaagcattaccagaaactggtgaagaaaatccattcatcggtacaactgtatttggtggattatcattagccttaggtgcagcgttattagctggacgtcgtcgcgaacta |
54. | ttggataaaaagtctgagaagcggggcattaaaatgacggtacaaagtgcatatatacatattccattttgtgtaagaatatgtacatattgtgatttcaataaatattttatacagaatcaacctgtagatgagtacttagatgcactaatcacagaaatgtctacagcaaaatataggatcttaaagaccatgtatgtaggtggcggcacaccaacggccctttctattaatcagttggaaagattacttaaagcaatacgtgatacgtttacaatcacaggcgagtatacatttgaagcaaatcctgatgagttaactaaagagaaagtccaactattagagaaatatggagtaaaaaggatttcaatgggcgttcaaacattcaagccggagttattgtctgttttaggtagaacgcacaatactgaagatatttacacttcggtgttaaatgctaaaaacgcaggtattaaatcaatcagtttagatttaatgtatcatttaccgaaacagacgattgaagattttgaacaaagtttagatctagctttagatatggatattcaacatatttcgagttacggcttaatacttgaacctaaaacccaattttataatatgtatagaaaaggcttgctcaaacttcctaatgaggatttaggtgctgacatgtatcagttgctgatgtctaagatagaacaatctcctttccatcaatacgaaatatctaattttgcattagatggccatgaatcagaacataataaggtttactggtttaatgaggaatattatggatttggagcaggtgcaagtggttatgtagatggtgtgcgttatacgaatatcaatccagtgaatcattatatcaaagctataaataaagaaagtaaagcaattttagtatcaaataaaccttctttgactgagagaatggaagaagaaatgtttcttgggttgcgtttaaatgaaggtgtgagtagtagtaggttcaaaaagaagtttgaccaatctattgaaagtgtctttggtcaaacaataaataatttaaaagagaaggaattaattgtagaaaagaacgatgtgattgcacttacaaatagagggaaagtcataggtaatgaggtttttgaagctttcctaataaatgat |
55. | MRNIENLNPGDSVDHFFLVHKATQGVTAQGKDYMTLHLQDKSGEIEAKFWTATKNDMATIKPEEIVHVKGDIINYRGNKQMKVNQIRLATTEDQLKTEQFVDGAPLSPAEIQEEISHYLLDIENANLQRITRHLLKKYQERFYTYPAASSHHHNFASGLSYHVLTMLRIAKSICDIYPLLNKSLLYSGIILHDIGKVRELSGPVATSYTVEGNLLGHISIASDEVVEAARELNIEGEEIMLLRHMILSHHGKLEYGSPKLPYLKEAEILCYIDNIDARMNMFEKAYKKTDKGQFTDKIFGLENRRFYNPESLD |
56. | MNKHHPKLRSFYSIRKSTLGVASVIVSTLFLITSQHQAQAAENTNTSDKISENQNNNATTTQPPKDTNQTQPATQPANTAKNYPAADESLKDAIKDPALENKEHDIGPREQVNFQLLDKNNETQYYHFFSIKDPADVYYTKKKAEVELDINTASTWKKFEVYENNQKLPVRLVSYSPVPEDHAYIRFPVSDGTQELKIVSSTQIDDGEETNYDYTKLVFAKPIYNDPSLVKSDTNDAVVTNDQSSSVASNQTNTNTSNQNTSTINNANNQPQATTNMSQPAQPKSSTNADQASSQPAHETNSNGNTNDKTNESSNQSDVNQQYPPADESLQDAIKNPAIIDKEHTADNWRPIDFQMKNDKGERQFYHYASTVEPATVIFTKTGPIIELGLKTASTWKKFEVYEGDKKLPVELVSYDSDKDYAYIRFPVSNGTREVKIVSSIEYGENIHEDYDYTLMVFAQPITNNPDDYVDEETYNLQKLLAPYHKAKTLERQVYELEKLQEKLPEKYKAEYKKKLDQTRVELADQVKSAVTEFENVTPTNDQLTDLQEAHFVVFESEENSESVMDGFVEHPFYTATLNGQKYVVMKTKDDSYWKDLIVEGKRVTTVSKDPKNNSRTLIFPYIPDKAVYNAIVKVVVANIGYEGQYHVRIINQDINTKDDDTSQNNTSEPLNVQTGQEGKVADTDVAENSSTATNPKDASDKADVIEPESDVVKDADNNIDKDVQHDVDHLSDMSDNNHFDKYDLKEMDTQIAKDTDRNVDKDADNSVGMSSNVDTDKDSNKNKDKVIQLNHIADKNNHTGKAAKLDVVKQNYNNTDKVTDKKTTEHLPSDIHKTVDKTVKTKEKAGTPSKENKLSQSKMLPKTGETTSSQSWWGLYALLGMLALFIPKFRKESK |
57. | MsdfnhtdhsttnhsqtpryrrpkfpwfktvivaliagiigallvlgigkvlnstilnkdGstvqttnnkggnqldgqskkfgtvhemiksvsptivgvinmqkassvddllkgksskpsEagvgsgviyqinnnsayivtnnhvidganeirvqlhnkkqvkaklvgkdavtdiavlkiEntkgikaiqfansskvqtgdsvfamgnplglqfansvtsgiisasertidaettggntkVsvlqtdaainpgnsggalvdingnlvginsmkiaatqvegigfaipsnevkvtieqlvkHgkidrpsigiglinlkdipeeereqlhtdredgiyvakadsdidlkkgdiiteidgkkiKddvdlrsylyenkkpgesvtvtvirdgktkevkvklkaqkeqpkrqsrsergspqqgdrdffr |
58. | VNQQQEKTTTTPTTINPLTGEKVGEGEPTTEVTKEPVDEITQFGGEEVPQGHKDEFDPNLPIDGTEEVPGKPGIKNPETGEVVTPPVDDVTKHGPKAGEPEVTKEEIPFEKKREFNPDLKPGEEKVTQEGQTGEKTTTTPTTINPLTGEKVGEGEPTTEVTKEPVDEITQFGGEEVPQGHKDEFDPNLPIDGTEEVPGKPGIKNPETGEVVTPPVDDVTKHGPKAGEPEVTKEEIPYETKRVLDPTMEPGSPDKVAQKGENGEKTTTTPTTINPLTGEKVGEGEPTTEVTKEPIDEIVNYAPEIIPHGTREEIDPNLPEGETKVIPGKDGLKDPETGEIIEEPQDEVIIHGAKDDSDADSDSDADSDSDADSDSDADSDSDADSDSDSDSDSDSDSDSDADSDSDADSDSDSDSDSDADSDSDADSDSDADSDSDADSDSDSDSDSDADSDSDSDSDSDADSDSDADSDSDADSDSDADSDSDSDSDSDADSDSDSDSDSDSDADSDSDSDSDADSDSDADSDSDADSDSDADSDSDSDSDSDSDSDSDSDSDRDSDADSDSDADSDSDSDSDSDADSDSDSDSDSDADSDSDADSDSDSDADSDSDSDSDSDADSDSDADSDSDADSDSDADSDSDSDSDSDSDSDSDADSDSDADSDSDADRDHNDKTDKPNNKELPDTGNDAQNNGTLFGSLFAALGGLFLVGRRRKNKNNEEK |
59. | MKSLKTVIGMNNKEHIKSVILALLVLMSVVLTYMVWNFSPDIANVDNTDSKKSETKPLTTPMTAKMDTTITPFQIIHSKNDHPEGTIATVSNVNKLTKPLKNKEVKSVEHVRRDHNLMIPDLNSDFILFDFTYDLPLSTYLGQVLNMNAKVPNHFNFNRLVIDHDADDNIVLYAISKDRHDYVKLTTTTKNDHFLDALAAVKKDMQPYTDIITNKDTIDRTTHVFAPSKPEKLKTYRMVFNTISVEKMNAILFDDSTIVRSSKSGVTTYNNNTGVANYNDKNEKYHYKNLSEDEASSSKMEETIPGTFDFINGHGGFLNEDFRLFSTNNQSGELTYQRFLNGYPTFNKEGSNQIQVTWGEKGVFDYRRSLLRTDVVLNSEDNKSLPKLESVRSSLANNSDINFEKVTNIAIGYEMQDNSDHNHIEVQINSELVPRWYVEYDGEWYVYNDGRLE |
60. | MSKRQKAFHDSLANEKTRVRLYKSGKNWVKSGIKEIEMFKIMGLPFISHSLVSQDNQSISKKMTGYGLKTTAVIGGAFTVNMLHDQQAFAASDAPLTSELNTQSETVGNQNSTTIEASTSTADSTSVTKNSSSVQTSNSDTVSSEKSEKVTSTTNSTSNQQEKLTSTSESTSSKNTTSSSDTKSVASTSSTEQPINTSTNQSTASNNTSQSTTPSSVNLNKTSTTSTSTAPVKLRTFSRLAMSTFASAATTTAVTANTITVNKDNLKQYMTTSGNATYDQSTGIVTLTQDAYSQKGAITLGTRIDSNKSFHFSGKVNLGNKYEGHGNGGDGIGFAFSPGVLGETGLNGAAVGIGGLSNAFGFKLDTYHNTSKPNSAAKANADPSNVAGGGAFGAFVTTDSYGVATTYTSSSTADNAAKLNVQPTNNTFQDFDINYNGDTKVMTVKYAGQTWTRNISDWIAKSGTTNFSLSMTASTGGATNLQQVQFGTFEYTESAVTQVRYVDVTTGKDIIPPKTYSGNVDQVVTIDNQQSALTAKGYNYTSVDSSYASTYNDTNKTVKNTNAGQSVTYYFTDVKAPTVTVGNQTIEVGKTMNPIVLTTTDNGTGTVTNTVTGLPSGLSYDSATNSIIGTPTKIGQSTVTVVSTDQANNKSTTTFTINVVDTTAPTVTPIGDQSSEVYSPISPIKIATQDNSGNAVTNTVTGLPSGLTFDSTNNTISGTPTNIGTSTISIVSTDASGNKTTTTFKYEVTRNSMSDSVSTSGSTQQSQSVSTSKADSQSASTSTSGSIVVSTSASTSKSTSVSLSDSVSASKSLSTSESNSVSSSTSTSLVNSQSVSSSMSDSASKSTSLSDSISNSSSTEKSESLSTSTSDSLRTSTSLSDSLSMSTSGSLSKSQSLSTSISGSSSTSASLSDSTSNAISTSTSLSESASTSDSISISNSIANSQSASTSKSDSQSTSISLSTSDSKSMSTSESLSDSTSTSGSVSGSLSIAASQSVSTSTSDSNSTSEIVSDSISTSGSLSASDSKSMSVSSSMSTSQSGSTSESLSDSQSTSDSDSKSLSQSTSQSGSTSTSTSTSASVRTSESQSTSGSMSASQSDSMSISTSFSDSTSDSKSASTASSESISQSASTSTSGSVSTSTSLSTSNSERTSTSMSDSTSLSTSESDSISESTSTSDSISEAISASESTFISLSESNSTSDDESQSASAFLSESLSESTSESTSESVSSSTSESTSLSDSTSESGSTSTSLSNSTSGSTSISTSTSISESTSTFKSESVSTSLSMSTSTSLSDSTSLSTSLSDSTSDSKSDSLSTSNSTSDSISTSKSDSISTSTSLSGSTSESKSDSTSMSISMSQSTSGSTSTSTSTSLSSDTSTSLSLSASMNQSGVDSNSASQSASNSTSTSTSESDSQSTSSYTSQSTSQSESTSTSTSLSDSTSISKSTSQSGSVSTSASLSGSESESDSQSISTSASESTSESASTSLSDSTSTSNSGSASTSTSLSNSASASESDLSSTSLSDSTSASMQSSESDSQSTSASLSDSLSTSTSNRMSTIASLSTSVSTSESGSTSESTSESDSTSTSLSDSQSTSRSTSASGSASTSTSTSDSRSTSASTSTSMRTSTSDSQSMSLSTSTSTSMSDSTSLSDSVSDSTSDSTSASTSGSMSVSISLSDSTSTSTSASEVMSASISDSQSMSESVNDSESVSESNSESDSKSMSGSTSVSDSGSLSVSTSLRKSESVSESSSLSCSQSMSDSVSTSDSSSLSVSTSLRSSESVSESDSLSDSKSTSGSTSTSTSGSLSTSTSLSGSESVSESTSLSDSISMSDSTSTSDSDSLSGSISLSGSTSLSTSDSLSDSKSLSSSQSMSGSESTSTSVSDSQSSSTSNSQFDSMSISASESDSMSTSDSSSISGSNSTSTSLSTSDSMSGSVSVSTSTSLSDSISGSTSVSDSSSTSTSTSLSDSMSQSQSTSTSASGSLSTSISTSMSMSASTSSSQSTSVSTSLSTSDSISDSTSISISGSQSTVESESTSDSTSISDSESLSTSDSDSTSTSTSDSTSGSTSTSISESLSTSGSGSTSVSDSTSMSESNSSSVSMSQDKSDSTSISDSESVSTSTSTSLSTSDSTSTSESLSTSMSGSQSISDSTSTSMSGSTSTSESNSMHPSDSMSMHHTHSTSTSRLSSEATTSTSESQSTLSATSEVTKHNGTPAQSEKRLPDTGDSIKQNGLLGGVMTLLVGLGLMKRKKKKDENDQDDSQA |
61. | MPKNKILIYLLSTTLVLPTLVSPTAYSDTPQKDTTAKTTSHDSKKSNDDETSKDTTSKDIDKADKNNTSNQDNNDKKFKTIDDSTSDSNNIIDFIYKNLPQTNINQLLTKNKYDDNYSLTTLIQNLFNLNSDISDYEQPRNGEKSTNDSNKNSDNSIKNDTDTQSSKQDKADNQKAPKSNNTKPSTSNKQPNSPKPTQPNQSNSQPASDDKANQKSSSKDNQSMSDSALDSILDQYSEDAKKTQKDYASQSKKDKNEKSNTKNPQLPTQDELKHKSKPAQSFNNDVNQKDTRATSLFETDPSISNNDDSGQFNVVDSKDTRQFVKSIAKDAHRIGQDNDIYASVMIAQAILESDSGRSALAKSPNHNLFGIKGAFEGNSVPFNTLEADGNQLYSINAGFRKYPSTKESLKDYSDLIKNGIDGNRTIYKPTWKSEADSYKDATSHLSKTYATDPNYAKKLNSIIKHYQLTQFDDERMPDLDKYERSIKDYDDSSDEFKPFREVSDSMPYPHGQCTWYVYNRMKQFGTSISGDLGDAHNWNNRAQYRDYQVSHTPKRHAAVVFEAGQFGADQHYGHVAFVEKVNSDGSIVISESNVKGLGIISHRTINAAAAEELSYITGK |
62. | MRKFSRYAFTSMAALTLLSTLSPAALAIDSKNKPANSDIKFEVTQKSDAVKALKELPKSENVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAKKVKPTNKVTLSKDDAADKAFKAVKIDKNKAKNLKDKVIKENKVEIDGDSNKYVYNVELITVTPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLTHQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDNQGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTFTSLSGANDVVAHELTHGVTQETANLEYKDQSGALNESFSDVFGYFVDDEDFLMGEDVYTPGKEGDALRSMSNPEQFGQPAHMKDYVETEKDNGGVHTNSGTPNKAAYNVTQATGKSKSEQTYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGVE |
63. | MKKRIDYLSNKQNKYSIRRFTVGTTSVIVGATILFGIGNHQAQASEQSNDTTQSSKNNASADSEKNNMIETPQLNTTANDTSDISANTNSANVDSTTKPMSTQTSNTTTTEPASTNETPQPTAIKNQATAAKMQDQTVPQEANSQVDNKTTNDANSIATNSELKNSQTLDLPQSSPQTISNAQGTSKPSVRTRAVRSLAVAEPVVNAADAKGTNVNDKVTASNFKLEKTTFDPNQSGNTFMAANFTVTDKVKSGDYFTAKLPDSLTGNGDVDYSNSNNTMPIADIKSTNGDVVAKATYDILTKTYTFVFTDYVNNKENINGQFSLPLFTDRAKAPKSGTYDANINIADEMFNNKITYNYSSPIAGIDKPNGANISSQIIGVDTASGQNTYKQTVFVNPKQRVLGNTWVYIKGYQDKIEESSGKVSATDTKLRIFEVNDTSKLSDSYYADPNDSNLKEVTDQFKNRIYYEHPNVASIKFGDITKTYVVLVEGHYDNTGKNLKTQVIQENVDPVTNRDYSIFGWNNENVVRYGGGSADGDSAVNPKDPTPGPPVDPEPSPDPEPEPTPDPEPSPDPEPEPSPDPDPDSDSDSDSGSDSDSGSDSDSESDSDSDSDSDSDSDSDSESDSDSESDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSDSESDSESDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSRVTPPNNEQKAPSNPKGEVNHSNKVSKQHKTDALPETGDKSENTNATLFGAMMALLGSLLLFRKRKQDHKEKA |
64. | MKKTIMASSLAVALGVTGYAAGTGHQAHAAEVNVDQAHLVDLAHNHQDQLNAAPIKDGAYDIHFVKDGFQYNFTSNGTTWSWSYEAANGQTAGFSNVAGADYTTSYNQGSNVQSVSYNAQSSNSNVEAVSAPTYHNYSTSTTSSSVRLSNGNTAGATGSSAAQIMAQRTGVSASTWAAIIARESNGQVNAYNPSGASGLFQTMPGWGPTNTVDQQINAAVKAYKAQGLGAWGF |
65. | MGGYLIMKKIVTATIATAGLATIAFAGHDAQAAEQNNNGYNSNDAQSYSYTYTIDAQGNYHYTWTGNWNPSQLTQNNTYYYNNYNTYSYNNASYNNYYNHSYQYNNYTNNSQTATNNYYTGGSGASYSTTSNNVHVTTTAAPSSNGRSISNGYASGSNLYTSGQCTYYVFDRVGGKIGSTWGNASNWANAAASSGYTVNNTPKVGAIMQTTQGYYGHVAYVEGVNSNGSVRVSEMNYGHGAGVVTSRTISANQAGSYNFIH |
66. | MANTKKTTLDITGMTCAACSNRIEKKLNKLDDVNAQVNLTTEKATVEYNPDQHDVQEFINTIQHLGYGVAVETVELDITGMTCAACSSRIEKVLNKNDGVQNATVNLTTEQAKVDYYPEETDADKLVTRIQKLGYDASIKDNNKDQTSRKAEALQHKLIKLIISAVLSLPLLMLMFVHLFNMHIPALFTNPWFQFILATPVQFIIGWQFYVGAYKNLRNGGANMDVLVAVGTSAAYFYSIYEMVRWLNGSTTQPHLYFETSAVLITLILFGKYLEARAKSQTTNALGELLSLQAKEARILKDGNEVMIPLNEVHVGDTLIVKPGEKIPVDGKIIKGMTAIDESMLTGESIPVEKNVDDTVIGSTMNKNGTITMTATKVGGDTALANIIKVVEEAQSSKAPIQRLADIISGYFVPIVVGIALLTFIVWITLVTPGTFEPALVASISVLVIACPCALGLATPTSIMVGTGRAAENGILFKGGEFVERTHQIDTIVLDKTGTITNGRPVVTDYHGDNQTLQLLATAEKDSEHPLAEAIVNYAKEKQLILTETTTFKAVPGHGIEATIDHHHILVGNRKLMADNDISLPKHISDDLTHYERDGKTAMLIAVNYSLTGIIAVADTVKDHAKDAIKQLHDMGIEVAMLTGDNKNTAQAIAKQVGIDTVIADILPEEKAAQIAKLQQQGKKVAMVGDGVNDAPALVKADIGIAIGTGTEVAIEAADITILGGDLMLIPKAIYASKATIRNIRQNLFWAFGYNIAGIPIAALGLLAPWVAGAAMALSSVSVVTNALRLKKMRLEPRRKDA |
67. | MFDSIRETIDYAVENNMSFADIMVKEEMELSGKSRDEVRAQMKQNLDVMRDAVIKGTTGDGVESVTGYTGHDAAKLRDYNETHHALSGYEMIDAVKGAIATNEVNAAMGIICATPTAGSSGTIPGALFKLEKTHDLTEEQMIDFLFTSALFGRVVANNASVAGATGGCQAEVGSASAMAAAAAVAIFGGSPEASGHAMALAISNLLGLVCDPVAGLVEIPCVMRNAIGSGNALISADLALAGIESRIPVDEVIEAMDKVGRNLPASLRETGLGGLAGTPTGEAIKRKIFGTAEDMVKNN |
68. | MKNNLRYGIRKHKLGAASVFLGTMIVVGMGQDKEAAASEQKTTTVEENGNSATDNKTSETQTTATNVNHIEETQSYNATVTEQPSNATQVTTEEAPKAVQAPQTAQPANIETVKEEVVKEEAKPQVKETTQSQDNSGDQRQVDLTPKKATQNQVAETQVEVAQPRTASESKPRVTRSADVAEAKEASNAKVETGTDVTSKVTVEIGSIEGHNNTNKVEPHAGQRAVLKYKLKFENGLHQGDYFDFTLSNNVNTHGVSTARKVPEIKNGSVVMATGEVLEGGKIRYTFTNDIEDKVDVTAELEINLFIDPKTVQTNGNQTITSTLNEEQTSKELDVKYKDGIGNYYANLNGSIETFNKANNRFSHVAFIKPNNGKTTSVTVTGTLMKGSNQNGNQPKVRIFEYLGNNEDIAKSVYANTTDTSKFKEVTSNMSGNLNLQNNGSYSLNIENLDKTYVVHYDGEYLNGTDEVDFRTQMVGHPEQLYKYYYDRGYTLTWDNGLVLYSNKANGNGKNGPIIQNNKFEYKEDTIKETLTGQYDKNLVTTVEEEYDSSTLDIDYHTAIDGGGGYVDGYIETIEETDSSAIDIDYHTAVDSEAGHVGGYTESSEESNPIDFEESTHENSKHHADVVEYEEDTNPGGGQVTTESNLVEFDEESTKGIVTGAVSDHTTVEDTKEYTTESNLIELVDELPEEHGQAQGPVEEITENNHHISHSGLGTENGHGNYDVIEEIEENSHVDIKSELGYEGGQNSGNQSFEEDTEEDKPKYEQGGNIVDIDFDSVPQIHGQNKGNQSFEEDTEKDKPKYEHGGNIIDIDFDSVPHIHGFNKHTEIIEEDTNKDKPSYQFGGHNSVDFEEDTLPKVSGQNEGQQTIEEDTTPPIVPPTPPTPEVPSEPETPTPPTPEVPSEPETPTPPTPEVPSEPETPTPPTPEVPAEPGKPVPPAKEEPKKPSKPVEQGKVVTPVIEINEKVKAVAPTKKPQSKKSELPETGGEESTNKGMLFGGLFSILGLALLRRNKKNHKA |
69. | LHLRENIIVKSNLRYGIRKHKLGAASVFLGTMIVVGMGQEKEAAASEQNNTTVEESGSSATESKASETQTTTNNVNTIDETQSYSATSTEQPSQSTQVTTEEAPKTVQAPKVETSRVDLPSEKVADKETTGTQVDIAQPSNVSEIKPRMKRSTDVTAVAEKEVVEETKATGTDVTNKVEVEEGSEIVGHKQDTNVVNPHNAERVTLKYKWKFGEGIKAGDYFDFTLSDNVETHGISTLRKVPEIKSTDGQVMATGEIIGERKVRYTFKEYVQEKKDLTAELSLNLFIDPTTVTQKGNQNVEVKLGETTVSKIFNIQYLGGVRDNWGVTANGRIDTLNKVDGKFSHFAYMKPNNQSLSSVTVTGQVTKGNKPGVNNPTVKVYKHIGSDDLAESVYAKLDDVSKFEDVTDNMSLDFDTNGGYSLNFNNLDQSKNYVIKYEGYYDSNASNLEFQTHLFGYYNYYYTSNLTWKNGVAFYSNNAQGDGKDKLKEPIIEHSTPIELEFKSEPPVEKHELTGTIEESNDSKPIDFEYHTAVEGAEGHAEGTIETEEDSIHVDFEESTHENSKHHADVVEYEEDTNPGGGQVTTESNLVEFDEDSTKGIVTGAVSDHTTIEDTKEYTTESNLIELVDELPEEHGQAQGPIEEITENNHHISHSGLGTENGHGNYGVIEEIEENSHVDIKSELGYEGGQNSGNQSFEEDTEEDKPKYEQGGNIVDIDFDSVPQIHGQNNGNQSFEEDTEKDKPKYEQGGNIIDIDFDSVPHIHGFNKHTEIIEEDTNKDKPNYQFGGHNSVDFEEDTLPQVSGHNEGQQTIEEDTTPPIVPPTPPTPEVPSEPETPTPPTPEVPSEPETPTPPTPEVPTEPGKPIPPAKEEPKKPSKPVEQGKVVTPVIEINEKVKAVVPTKKAQSKKSELPETGGEESTNNGMLFGGLFSILGLALLRRNKKNHKA |
70. | MQMRDKKGPVNKRVDFLSNKLNDYSIRKFTVGTASILIGSLMYLGTQQEAEAAENNIENPTTLKDNVQSKEVKIEEVTNKDTAPQGVEAKSEVTSNKDTIEHEPSVKAEDISKKEDTPKEVADVAEVQPKSSVTHNAETPKVRKARSVDEGSFDITRDSKNVVESTPITIQGKEHFEGYGSVDIQKKPTDLGVSEVTRFNVGNESNGLIGALQLKNKIDFSKDFNFKVRVANNHQSNTTGADGWGFLFSKGNAEEYLTNGGILGDKGLVNSGGFKIDTGYIYTSSMDKTEKQAGQGYRGYGAFVKNDSSGNSQMVGENIDKSKTNFLNYADNSTNTSDGKFHGQRLNDVILTYVASTGKMRAEYAGKTWETSITDLGLSKNQAYNFLITSSQRWGLNQGINANGWMRTDLKGSEFTFTPEAPKTITELEKKVEEIPFKKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGVIISKGEPKEEITKDPINELTEYGPETIAPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFXKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFKKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFEKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPVNELTEFGGEKIPQGHKDIFDPNLPTDQTEKVPGKPGIKNPDTGKVIEEPVDDVIKHGPKTGTPETKTVEIPFETKREFNPKLQPGEERVKQEGQPGSKTITTPITVNPLTGEKVGEGQPTEEITKQPVDKIVEFGGEKPKDPKGPENPEKPSRPTHPSGPVNPNNPGLSKDRAKPNGPVHSMDKNDKVKKSKIAKESVANQEKKRAELPKTGLESTQKGLIFSSIIGIAGLMLLARRRKN |
71. | MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQEKNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEANSKLPKDLRDKNNRFVEKVSIEKAEVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKVESPKVEVPQIQSPKVEVPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYYNTYYKYKGAIDQTVLTVLGSGSKSYIQPLKVDDKNGYLAKSYAQVRNYVTESINTGKVLYTFYQNPTLVKTAIKAQETASSIKNTLSNLLSFWK |
72. | MAVFSKEKKRGCIVVIETFKAFVIDKDESGKVTPTFKQLSPTDLPKGDVLIKVHYSGINYKDALATQDHNAVVKSYPMIPGIDLAGTIVESEAPGFEKGEQVIVTSYDLGVSHYGGFSEYARVKSEWIIKLPDTLTLEESMIYGTAGYTAGLAIERLEKVGMNIEDGPVLVRGASGGVGTLAVLMLNELGYKVIASTGKQDVSDQLLELGAKEVIDRLPVEDDHDDPLASSTWQACVDPVGGEGINYVTKRLNHSGSIAVIGMTAGNTYTNSVFPHILRGVNILGIDSVFTAMKLRQRVWRRLAKDLMPENLHEIKQVITFDELPEQLNKVIKHENKGRIVIDFGVDK |
73. | MKKLVTATTLTAGIGTALVGQAYHADAAENYTNYNNYNYNTTQTTTTTTTTTTTSSISHSGNLYTAGQCTWYVYDKVGGEIGSTWGNANNWAAAAQGAGFTVNHTPSKGAILQSSEGPFGHVAYVESVNSDGSVTISEMNYSGGPFSVSSRTISASEAGNYNYIHI |
74. | MKKIATATIATAGFATIAIASGNQAHASEQDNYGYNPNDPTSYSYTYTIDAQGNYHYTWKGNWHPSQLNQDNGYYSYYYYNGYNNYNNYNNGYSYNNYSRYNNYSNNNQSYNYNNYNSYNTNSYRTGGLGASYSTSSNNVQVTTTNAPSSNGRSISSGYTSGRNLYTSGQCTYYVFDRVGGKIGSTWGNASNWANAAARAGYTVNNTPKAGAIMQTTQGAYGHVAYVESVNSNGSVRVSEMNYGYGPGVVTSRTISASQAAGYNFIH |
75. | MSMTYRIKKWQKLSTITLLMAGVITLNGGEFRSVDKHQIAVADTNVQTPDYEKLRNTWLDVNYGYDKYDENNPDMKKKFDATEKEATNLLKEMKTESGRKYLWSGAETLETNSSHMTRTYRNIEKIAEAMRNPKTTLNTDENKKKVKDALEWLHKNAYGKEPDKKVKELSENFTKTTGKNTNLNWWDYEIGTPKSLTNTLILLNDQFSNEEKKKFTAPIKTFAPDSDKILSSVGKAELAKGGNLVDISKVKLLECIIEEDKDMMKKSIDSFNKVFTXVQDSATGKERNGFYKDGSYIDHQDVPYTGAYGVVLLEGISQMMPMIKETPFNDKTQNDTTLKSWIDDGFMPLIYKGEMMDLSRGRAISRENETSHSASATVMKSLLRLSDAMDDSTKAKYKKIVKSSVESDSSYKQNDYLNSYSDIDKMKSLMTDNSISKNGLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNVARYESINGENLKGWHTGAGMSYLYNSDVKHYHDNFWVTADMKRLSGTTTLDNEILKDTDDKKSSKTFVGGTKVDDQHASIGMDFENQDKTLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENRKANGYTLYTDDKQTTNSDNQENNSVFLESTDTKKNIGYHFLNKPKITVKKESHTGKWKEINKSQKDTQKTDEYYEVTQKHSNSDNKYGYVLYPGLSKDVFKTKKDEVTVVKQEDDFHVVKDNESVWAGVNYSNSTQTFDINNTKVEVKAKGMFILKKKDDNTYECSFYNPESTNSASDIESKISMTGYSITNKNTSTSNESGVHFELTK |
76. | MNDLKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN |
77. | VSREMSYHWFKKMLLSTSILILSSSSLGLATHTVEAKDNLNGEKFTTNLNHNITSPSVNSEMNNNETGTPHESNQTGNEGTGSNSRDANPDSNNVKPDSNNQNPSTDSKPDPNNQNPSPNPKPDPDNPKPKPDPKPDPDKPKPNPDPKPDPDNPKPNPDPKPDPDKPKPNPDPKPDPDKPKPNPNPKPDPNKPNPNPSPDPDQPGDSNHSGGSKNGGTWNPNASDGSNQGQWQPNGNQGNSQNPTGNDFVSQRFLALANGAYKYNPYILNQINKLGKDYGEVTDEDIYNIIRKQNFSGNAYLNGLQQQSNYFRFQYFNPLKSERYYRNLDEQVLALITGEIGSMPDLKKPEDKPDSKQRSFEPHEKDDFTVVKKQEDNKKSASTAYSKSWLAIVCSMMVVFSIMLFLFVKRNKKKNKNESQRR |
78. | MKNKKRVLIASSLSCAILLLSAATTQANSAHKDSQDQNKKEHVDKSQQKDKRNVTNKDKNSTAPDDIGKNGKITKRTETVYDEKTNILQNLQFDFIDDPTYDKNVLLVKKQGSIHSNLKFESHKEEKNSNWLKYPSEYHVDFQVKRNRKTEILDQLPKNKISTAKVDSTFSYSSGGKFDSTKGIGRTSSNSYSKTISYNQQNYDTIASGKNNNWHVHWSVIANDLKYGGEVKNRNDELLFYRNTRIATVENPELSFASKYRYPALVRSGFNPEFLTYLSNEKSNEKTQFEVTYTRNQDILKNRPGIHYAPPILEKNKDGQRLIVTYEVDWKNKTVKVVDKYSDDNKPYKEG |
79. | MYTRTATTSDSQKNITQSLQFNFLTEPNYDKETVFIKAKGTIGSGLRILDPNGYWNSTLRWPGSYSVSIQNVDDNNNTNVTDFAPKNQDESREVKYTYGYKTGGDFSINRGGLTGNITKESNYSETISYQQPSYRTLLDQSTSHKGVGWKVEAHLINNMGHDHTRQLTNDSDNRTKSEIFSLTRNGNLWAKDNFTPKDKMPVTVSEGFNPEFLAVMSHDKKDKGKSQFVVHYKRSMDEFKIDWNRHGFWGYWSGENHVDKKEEKLSALYEVDWKTHNVKFVKVLNDNEKK |
80. | VVDFMNYPNGKPYRKNSAIDGGKKTAAFSNIEYGGRGMSLEKDIEHSNTFYLKSDIAVIHKKPTPVQIVNVNYPKRSKAVINEAYFRTPSTTDYNGVYQGYYIDFEAKETKNKTSFPLNNIHDHQVEHMKNAYQQKGIVFLMIRFKTLDEVYLLPYSKFEVFWKRYKDNIKXSITVDEIRKNGYHIPYQYQPRLDYLKAVDKLILDESEDRV |
81. | VNTTKAALHGDVKLQNDKDHAKQTVSQLAHLNNAQKHMEDTLIDSETTRTAVKQDLTEAQALDQLMDALQQSIADKDATRASSAYVNAEPNKKQSYDEAVQNAESIIAGLNNPTINKGNVSSATQAVISSKNALDGVERLAQDKQTAGNSLNHLDQLTPAQQQALENQINNATTRGEVAQKLTEAQALNQAMEALRNSIQDQQQTEAGSKFINEDKPQKDAYQAAVQNAKDLINQTNNPTLDKAQVEQLTQAVNQAKDNLHGDQKLADDKQHAVTDLNQLNGLNNPQRQALESQINNAATRGEVAQKLAEAKALDQAMQALRNSIQDQQQTESGSKFINEDKPQKDAYQAAVQNAKDLINQTGNPTLDKSQVEQLTQAVTTAKDNLHGDQKLARDQQQAVTTVNALPNLNHAQQQALTDAINAAPTRTEVAQHVQTATELDHAMETLKNKVDQVNTDKAQPNYTEASTDKKEAVDQALQAAESITDPTNGSNANKDAVDQVLTKLQEKENELNGNERVAEAKTQAKQTIDQLTHLNADQIATAKQNIDQATKLQPIAELVDQATQLNQSMDQLQQAVNEHANVEQTVDYTQADSDKQNAYKQAIADAENVLKQNANKQQVDQALQNIINAKQALNGDERVALAKTNGKHDIDQLNALNNAQQDGFKGRIDQSNDLNQIQQIVDEAKALNRAMDQLSQEITDNEGRTKGSTNYVNADTQVKQVYDETVDKAKQALDKSTGQNLTAKQVIKLNDAVTAAKKALNGEERLNNRKAEALQRLDQLTHLNNAQRQLAIQQINNAETLNKASRAINRATKLDNAMGAVQQYIDEQHLGVISSTNYINADDNLKANYDNAIANAAHELDKVQGNAIAKAEAEQLKQNIIDAQNALNGDQNLANAKDKANAFVNSLNGLNQQQQDLAHKAINNADTVSDVTDIVNNQIDLNDAMETLKHLVDNEIPNAEQTVNYQNADDNAKTNFDDAKRLANTLLNSDNTNVNDINGAIQAVNDAIHNLNGDQRLQDAKDKAIQSINQALANKLKEIEASNATDQDKLIAKNKAEELANSIINNINKATSNQAVSQVQTAGNHAIEQVHANEIPKAKIDANKDVDKQVQALIDEIDRNPNLTDKEKQALKDRINQILQQGHNGINNAMTKEEIEQAKAQLAQALQDIKDLVKAKEDAKQDVDKQVQALIDEIDQNPNLTDKEKQALKDRINQILQQGHXDIXNAMTKEAIEQAKERLAQALQDIKDLVKAKEDAKNDIDKRVQALIDEIDQNPNLTDKEKQALKDRINQILQQGHNDINNALTKEEIEQAKAQLAQALQDIKDLVKAKEDAKNAIKALANAKRDQINSNPDLTPEQKAKALKEIDEAEKRALQNVENAQTIDQLNRGLNLGLDDIRNTHVWEVDEQPAVNEIFEATPEQILVNGELIVHRDDIITEQDILAHINLIDQLSAEVIDTPSTATISDSLTAKVEVTLLDGSKVIVNVPVKVVEKELSVVKQQAIESIENAAQQKINEINNSVTLTLEQKEAAIAEVNKLKQQAIDHVNNAPDVHSVEEIQQQEQAHIEQFNPEQFTIEQAKSNAIKSIEDAIQHMIDEIKARTDLTDKEKQEAIAKLNQLKEQAIQAIQRAQSIDEISEQLEQFKAQMKAANPTAKELAKRKQEAISRIKDFSNEKINSIRNSEIGTADEKQAAMNQINEIVLETIRDINNAHTLQQVEAALNNGIARISAVQIVTSDRAKQSSSTGNESNSHLTIGYGTANHPFNSSTIGHKKKLDEDDDIDPLHMRHFSNNFGNVIKNAIGVVGISGLLASFWFFIAKRRRKEDEEEELEIRDNNKDSIKETLDDTKHLPLLFAKRRRKEDEEDVTVEEKDSLNNGESLDKVKHTPFFLPKRRRKEDEEDVEVTNENTDEKVLKDNEHSPLLFAKRRKDKEEDVETTTSIESKDEDVPLLLAKKKNQKDNQSKDKKSASKNTSKKVAAKKKKKKAKKNKK |
82. | MNQEVKNKIFSILKITFATALFIFVAITLYRELSGINFKDTLVEFSKINRMSLVLLFIGGGASLVILSMYDVILSRALKMDISLGKVLRVSYIINALNAIVGFGGFIGAGVRAMVYKNYTHDKKKLVHFISLILISMLTGLSLLSLLIVFHVFDASLILDKITMVRWVLYVVSFFLPLFIIYSMVRPPDKNNRFVGLYCTLVSCVEWLAAAVVLYFCGVIVDAHVSFMSFIAIFIIAALSGLVSFIPGGFGAFDLVVLLGFKTLGVPEEKVLLMLLLYRFAYYFVPVIIALILSSFEFGTSAKKYIEGSKYFIPAKDVTSFLMSYQKDIIAKIPSLSLAILVFFTSMIFFVNNLTIVYDALYDGNHLTYYILLAIHTSACLLLLLNVVGIYKQSRRAIIFAMISILLITVATFFTYASYILITWLAIIFVLLIVAFRRARRLKRPVRMRNIVAMLLFSLFILYVNHIFIAGTLYALDIYTIEMHTSVLRYYFWLTILIIAIIIGMIAWLFDYQFSKVRISSKIEDCEEIINQYGGNYLSHLIYSGDKQFFTNENKTAFLMYRYKASSLVVLGDPLGDENAFDELLEAFYNYAEYLGYDVIFYQVTDQHMPLYHNFGNQFFKLGEEAIIDLTQFSTSGKKRRGFRATLNKFDELNISFEIIEPPFSTEFINELQHVSDLWLDNRQEMHFSVGEFNEEYLSKAPIGVMRNEENEVIAFCSLMPTYFNDAISVDLIRWLPELDLPLMDGLYLHMLLWSKEQGYTKFNMGMATLSNVGQLHYSYLRERLAGRVFEHFNGLYRFQGLRRYKSKYNPNWEPRFLVYRKDNSLWESLSKVMRVIRHK |
83. | MVALTLVGSAVTAHQVQAAETTQDQTTNKNVLDSNKVKATTEQAKAEVKNPTQNISGTQVYQDPAIVQPKTANNKTGNAQVSQKVDTAQVNGDTRANQSATTNNTQPVAKSTSTTAPKTNTNVTNAGYSLVDDEDDNSENQINPELIKSAAKPAALETQYKTAAPKAATTSAPKAKTEATPKVTTFSASAQPRSVAATPKTSLPKYKPQVNSSINDYIRKNNLKAPKIEEDYTSYFPKYAYRNGVGRPEGIVVHDTANDRSTINGEISYMKNNYQNAFVHAFVDGDRIIETAPTDYLSWGVGAVGNPRFINVEIVHTHDYASFARSMNNYADYAATQLQYYGLKPDSAEYDGNGTVWTHYAVSKYLGGTDHADPHGYLRSHNYSYDQLYDLINEKYLIKMGKVAPWGTQSTTTPTTPSKPTTPSKPSTGKLTVAANNGVAQIKPTNSGLYTTVYDKTGKATNEVQKTFAVSKTATLGNQKFYLVQDYNSGNKFGWVKEGDVVYNTAKSPVNVNQSYSIKPGTKLYTVPWGTSKQVAGSVSGSGNQTFKASKQQQIDKSIYLYGSVNGKSGWVSKAYLVDTAKPTPTPTPKPSTPTTNNKLTVSSLNGVAQINAKNNGLFTTVYDKTGKPTKEVQKTFAVTKEASLGGNKFYLVKDYNSPTLIGWVKQGDVIYNNAKSPVNVMQTYTVKPGTKLYSVPWGTYKQEAGAVSGTGNQTFKATKQQQIDKSIYLFGTVNGKSGWVSKAYLAVPAAPKKAVAQPKTAVKAYTVTKPQTTQTVSKIAQVKPNNTGIRASVYEKTAKNGAKYADRTFYVTKERAHGNETYVLLNNTSHNIPLGWFNVDVYLYGTINNRTGWVNAKDLTAPTAVKPTTSAAKDYNYTYVIKNGNGYYYVTPNSDTAKYSLKAFNEQPFAVVKEQVINGQTWYYGKLSNGKLAWIKSTDLAKELIKYNQTGMALNQVAQIQAGLQYKPQVQRVPGKWTGANFNDVKHAMDTKRLAQDPALKYQFLRLDQPQNISIDKINQFLKGKGVLENQGAAFNKAAQMYGINEVYLISHALLETGNGTSQLAKGADVVNNKVVTNSNTKYHNVFGIAAYDNDPLREGIKYAKQAGWDTVSKAIVGGAKFIGNSYVKAGQNTLYKMRWNPAHPGTHQYATDVDWANINAKIIKGYYDKIGEVGKYFDIPQYK |
84. | MKGKFLKVSSLFVATLTTATLVSSPAANALSSKAMDNHPQQTQSSKQQTPKIQKGGNLKPLEQREHANVILPNNDRHQITDTTNGHYAPVTYIQVEAPTGTFIASGVVVGKDTLLTNKHVVDATHGDPHALKAFPSAINQDNYPNGGFTAEQITKYSDEGDLAIVKFSPNEQHKHIGEVVKPATMSNNADTQVNQNITVTGYPGDKPVATMWESKGKITYLKGEAMQYDLSTTGGNSGSPVFNEKNEVIGIHWXGVPNEFNGAVFINENVRNFLKQNIEDIHFATMTNLITQIILITLTILITLTTQMNQITLTTLTTLIIQTMAIXIIQTIQMQLN |
85. | MQKKVIAAIIGTSAISAVAATQANAATTHTVKPGESVWAISNKYGISIAKLKSLNNLTSNLIFPNQVLKVSGSSNSTSNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQNIMRLNGLNNFFIYPGQKLKVSGTASSSNAASNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQKIMSLNGLNNFFIYPGQKLKVTGNASTNSGSATTTNRGYNTPVFSHQNLYTWGQCTYHVFNRRAEIGKGISTYWWNANNWDNAAAADGYTIDNRPTVGSIAQTDVGYYGHVMFVERVNNDGSILVSEMNYSAAPGILTYRTVPAYQVNNYRYIH |
86. | MNNKKTATNRKGMIPNRLNKFSIRKYSVGTASILVGTTLIFGLSGHEAKAAEHTNGELNQSKNETTAPSENKTTKKVDSRQLKDNTQTATADQPKVTMSDSATVKETSSNMQSPQNATANQSTTKTSNVTTNDKSSTTYSNETDKSNLTQAKDVSTTPKTTTIKPRTLNRMAVNTVAAPQQGTNVNDKVHFSNIDIAIDKGHVNQTTGKTEFWATSSDVLKLKANYTIDDSVKEGDTFTFKYGQYFRPGSVRLPSQTQNLYNAQGNIIAKGIYDSTTNTTTYTFTNYVDQYTNVRGSFEQVAFAKRKNATTDKTAYKMEVTLGNDTYSEEIIVDYGNKKAQPLISSTNYINNEDLSRNMTAYVNQPKNTYTKQTFVTNLTGYKFNPNAKNFKIYEVTDQNQFVDSFTPDTSKLKDVTDQFDVIYSNDNKTATVDLMKGQTSSNKQYIIQQVAYPDNSSTDNGKIDYTLDTDKTKYSWSNSYSNVNGSSTANGDQKKYNLGDYVWEDTNKDGKQDANEKGIKGVYVILKDSNGKELDRTTTDENGKYQFTGLSNGTYSVEFSTPAGYTPTTANVGTDDAVDSDGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKGVKVTLQNEKGEVIGTTETDENGKYRFDNLDSGKYKVIFEKPAGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYEEETSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDNDSDSDSDSDSDAGKHTPAKPMSTVKDQHKTAKALPETGSENNNSNNGTLFGGLFAALGSLLLFGRRKKQNK |
87. | MDINSEEYKQEVLIKDVVMLAARILLESGAEGTRVEDTMTRIAKKLGYSESNSFVTNTVIQFTLHSESFPRIFRITSRDTNLIKISQANKISRQITNNEISLAEAKTQLEKIYVAKRDSSLPFKGFAAAMIAMSFLYLQGGRLIDVLTAILAGSLGYLVTEILDRKLHAQFIPEFIGSLVIGIIAVIGHTLIPTGDLATIIIAAVMPIVPGVLITNAIQDLFGGHMLMFTTKSLEALVTAFGIGAGVGSVLILV |
88. | VIAIMNVIIDERKENAMTFNKVLLSWIVILIITTSIYLFWQLGDINDVFNQSILINVRLPRLLEALLTGMILTVAGLIFQTVLNNALADSFTLGLASGATFGSGLALFLGLTTLWIPVFSITFSLITLITVLVITSVLSQGYPVRILILSGLMIGALFNSLLYFLILLKPRKLNTIANYLFGGFGDAEYSNVSIIAITFIIALFGIFIILNQLKLLQLGELKSQSLGLNVQLITYIALCIASMITAINVAYVGIIGFIGMVIPQLIRKWQWKQSLGRQLALNIVTGGQIMVMADFIGSHILSPVQIPASIIIALIGIPVLFYMLISQSKRLH |
89. | MKKLAFAITATSGAAAFLTHHDAQASTQHTVQSGESLWSIAQKYNTSVESIKQNNQLDNNLVFPGQVISVGGSDAQNTSNTSPQAGSASSHTVQAGESLNIIASRYGVSVDQLMAANNLRGYLIMPNQTLQTPNGGSGGTTPTATTGSNGNASSFNHQNLYTAGQCTWYVFDRRAQAGSPISTYWSDAKYWAGNAANDGYQVNNTPSVGSTMQSTPGPYGHVAYVERVNGDGSILISEMNYTYGPINMNYRTIPASEVSSYAFIH |
90. | MPDSITIIDENKVIDVVLIAGRILLESGAETYRVEDTMNRIAHSYGLHNTYSFVSSTAIIFSLNDRTSTRLIRVQERTTDLEKIALTNSLSRKISNKELTIDEAKSEFIHLQHASLQYSFLTNFFAAAIACGFFLFMFGGVASDCWIAVIAGGSAFLTFSFVQRYIQIKFFSEFVAAAVVISIAATFTKLGIATNQDIITIASVMPLVPGILITNAIRDLLAGELLAGMSRGVEAALTAFAIGAGVAIVLLII |
91. | MGFLSKILDGNNKEIKQLGKLADKVIALEEKTAILTDEEIRNKTKQFQTELADIDNVKKQNDYLDKILPEAYALVREGSKRVFNMTPYKVQIMGGIAIHKGDIAEMRTGEGKTLTATMPTYLNALAGRGVHVITVNEYLSSVQSEEMAELYNFLGLTVGLNLNSKTTEEKREAYAQDITYSTNNELGFDYLRDNMVNYSEDRVMRPLHFAIIDEVDSILIDEARTPLIISGEAEKSTSLYTQANVFAKMLKQDEDYKYDEKTKAVHLTEQGADKAERMFKVENLYDVQNVDVISHINTALRAHVTLQRDVDYMVVDGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVQIQNESKTMASITFQNYFRMYNKLAGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRNDKSDLIYISQKGKFDAVVEDVVEKHKAGQPVLLGTVAVETSEYISNLLKKRGIRHDVLNAKNHEREAEIVAGAGQKGAVTIATNMAGRGTDIKLGEGVEELGGLAVIGTERHESRRIDDQLRGRSGRQGDKGDSRFYLSLQDELMIRFGSERLQKMMSRLGLDDSTPIESKMVSRAVESAQKRVEGNNFDARKRILEYDEVLRKQREIIYNERNSIIDEEDSSQVVDAMLRSTLQRSINYYINTADDEPEYQPFIDYINDIFLQEGDITEDDIKGKDAEDIFEVVWAKIEAAYQSQKDILEEQMNEFERMILLRSIDSHWTDHIDTMDQLRQGIHLRSYAQQNPLRDYQNEGHELFDIMMQNIEEDTCKFILKSVVQVEDNIEREKTTEFGEAKHVSAEDGKEKVKPKPIVKGDQVGRNDDCPCGSGKKFKNCHGK |
92. | MRESMSNQNYDYNKNEDGSKKKMSTTAKVVSIATVLLLLGGLVFAIFAYVDHSNKAKERMLNEQKQEQKEKRQKENAEKERKKKQQEEKEQNELDSQANQYQQLPQQNQYQYVPPQQQAPTKQRPAKEENDDKASKDESKDKDDKASQDKSDDNQKKTDDNKQPAQPKPQPQQPTPKPNNNQQNNQSNQQAKPQAPQQNSQSTTNKQNNANDK |
93. | MNMKKKEKHAIRKKSIGVASVLVGTLIGFGLLSSKEADASENSVTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKTSSNTNNGETSVAQNPAQQETTQSSSTNATTEETPVTGEATTTTTNQANTPATTQSSNTNAEELVNQTSNETTSNDTNTVSSVNSPQNSTNAENVSTTQDTSTEATPSNNESAPQSTDASNKDVVNQAVNTSAPRMRAFSLAAVAADAPAAGTDITNQLTNVTVGIDSGTTVYPHQAGYVKLNYGFSVPNSAVKGDTFKITVPKELNLNGVTSTAKVPPIMAGDQVLANGVIDSDGNVIYTFTDYVNTKDDVKATLTMPAYIDPENVKKTGNVTLATGIGSTTANKTVLVDYEKYGKFYNLSIKGTIDQIDKTNNTYRQTIYVNPSGDNVIAPVLTGNLKPNTDSNALIDQQNTSIKVYKVDNAADLSESYFVNPENFEDVTNSVNITFPNPNQYKVEFNTPDDQITTPYIVVVNGHIDPNSKGDLALRSTLYGYNSNIIWRSMSWDNEVAFNNGSGSGDGIDKPVVPEQPDEPGEIEPIPEDSDSDPGSDSGSDSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSDNSSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSDSESDSDSDSDSDSDSDSDSDSDSDSASDSDSGSDSDSSSDSDSESDSNSDSESGSNNNVVPPNSPKNGTNASNKNEAKDSKEPLPDTGSEDEANTSLIWGLLASIGSLLLFRRKKENKDKK |
94. | MNSNHAKASVTESVDKKFVVPESGINKIIPAYDEFKNSPKVNVSNLTDNKNFVASEDKLNKIADSSAASKIVDKNFVVPESKLGNIVPEYKEINNRVNVATNNPASQQVDKHFVAKGPEVNRFITQNKVNHHFITTQTHYKKVITSYKSTHVHKHVNHAKDSINKHFIVKPSESPRYTHPSQSLIIKHHFAVPGYHAHKFVTPGHASIKINHFCVVPQINSFKVIPPYGHNSHRMHVPSFQNNTTATHQNAKVNKAYDYKYFYSYKVVKGVKKYFSFSQSNGYKIGKPSLNIKNVNYQYAVPSYSPTHYVPEFKGSLPAPRV |
95. | LEHTIMKMRTIAKTSLALGLLTTGAITVTTQSVKAEKIQSTKVDKVPTLKAERLAMINITAGANSATTQAANTRQERTPKLEKAPNTNEEKTSASKIEKISQPKQEEQKTLNISATPAPKQEQSQTTTESTTPKTKVTTPPSTNTPQPMQSTKSDTPQSPTIKQAQTDMTPKYEDLRAYYTKPSFEFEKQFGFMLKPWTTVRFMNVIPNRFIYKIALVGKDEKKYKDGPYDNIDVFIVLEDNKYQLKKYSVGGITKTNSKKVNHKVELSITKKDNQGMISRDVSEYMITKEEISLKELDFKLRKQLIEKHNLYGNMGSGTIVIKMKNGGKYTFELHKKLQEHRMAGTNIDNIEVNIK |
96. | MTTIKTSNLGFPRLGRKREWKKAIESYWAKKISKEELDQTLTDLHKENLLLQKYYHLDSIPVGDFSLYDHILDTSLLFNIIPERFQGRTIDDDLLFDIARGNKDHVASALIKWFNTNYHYIVPEWDNVEPKVSRNVLLDRFKYAQSLNVNAHPVIVGPITFVKLSKGGHQTFEEKVKTLLPLYKEVFESLIDAGAEYIQVDEPILVTDDSESYENITREAYDYFEKAGVAKKLVIQTYFERAHLKFLSSLPVGGIGLDFVHDNGYNLKQIEAGDFDKSKTLYAGIIDGRNVWASDIEAKKVLIDKLLAHTNELVIQPSSSLLHVPVSLDDETLDTSVGEGLSFATEKLDELDALRRLFNQNDSVKYDKLKARYERFQNQSFKNLDYDFESVRTSRQSPFAQRIEQQQKRLNLPDLPTTTIGSFPQSREVRKYRADWKNKRITDEAYETFLKNEIARWIKIQEDIGLDVLVHGEFERNDMVEFFGEKLQGFLVTKFGWVQSYGSRAVKPPIIYGDVKWTAPLTVDETVYAQSLTDKPVKGMLTGPVTILNWSFERVDLPRKVVQDQIALAINEEVLALEAAGIKVIQVDEPALREGLPLRSEYHEQYLKDAVLSFKLATSSVRDETQIHTHMCYSQFGQIIHAIJDLDADVISIETSRSHGDLIKDFEDINYDLGIGLGVYDIHSPRIPTKEEITTAIMRSLQQIDRSLFWVNPDCGLKTRKEEEVKDALTVLVNAVKAKRQE |
97. | MSDTYKSYLVAVLCFTVLAIVLMPFLYFTTAWSIAGFASIATFIFYKEYFYEE |
98. | MLRGQEERKYSIRKYSIGVVSVLAATMFVVSSHEAQASEKTSTNAAAQKETLNQPGEQGNAITSHQMQSGKQLDDMHKENGKSGTVTEGKDTLQSSKHQSTQNSKTIRTQNDNQVLQDSERQGSKQSHQNNATNNTERQNDQVQNTHHAERNGSQSTTSQSNDVDKSQPSIPAQKVIPNHDKAAPTSTTPPSNDKTAPKSTKAQDATTDKHPNQQDTHQPAHQIIDAKQDDTVRQSEQKPQVGDLSKHIDGQNSPEKPTDKNTDNKQLIKDALQAPKTRSTTNAAADAKKVRPLKANQVQPLNKYPVVFVHGFLGLVGDNAPALYPNYWGGNKFKVIEELRKQGYNVHQASVSAFGSNYDRAVELYYYIKGGRVDYGAAHAAKYGHERYGKTYKGIMPNWEPGKKVHLVGHSMGGQTIRLMEEFLRNGNKEEIAYHKAHGGEISPLFTGGHNNMVASITTLATPHNGSQAADKFGNTEAVRKIMFALNRFMGNKYSNIDLGLTQWGFKQLPNESYIDYIKRVSKSKIWTSDDNAAYDLTLDGSAKLNNMTSMNPNITYTTYTGVSSHTGPLGYENPDLGTFFLMATTSRIIGHDAREEWRKNDGVVPVISSLHPSNQPFVNVTNDEPATRRGIWQVKPIIQGWD |
99. | MIHLIKGKMHHTVLCIHLNKGVALMNQYHSNAQQPSAWRFFVYSLVGILCFFIPFTINGNNTIFVDHVHLAIRSIIGPLMPYVALIMILIGTALPIVRRTFMTSITNLVITLFKVAGAMIGIMYVFKIGPSILFKANYGPFLFEKLMMPLSILIPVGAIALSLLVGYGLLEFVGVYMEPIMRPIFKTPGKSAVDAVASFVGSYSLGLLITNRVYKQGMYNKREATIIATGFSTVSATFMIIVAKTLGLMPHWNLYFWITLVITFVVTAITAWLPPISNESTEYYNGQEGEQEVAIEGSRLKTAYAEAMKQNALTPSLVKNVWDNLKDGLEMTVGILPSILSIGFLGLIVANYTPFIDWLGYIFYPFIYIFPIADQALLAKASAISIVEMFLPSLLVTKAAMSTKFVVGVVSVSAIIPFSALVPCILATEIKIPVWKLIIIWFLRVASLLITIPVALLLIFG |
100. | MVIMKKTILLTMTTLTLFSMSPNSAQAYTNDSKTLEEAKKAHPNAQFKVNKDTGAYTYTYDKNNTPNNNHQNQSRTNDNHQHANQRDLNNNQYHSSLSGQYTHINDAIDSHTPPQTSPSNPLTPAIPNVEDNDDELNNAFSKDNKGLITGIDLDELYDELQIAEFNDKAKTADGKPLALGNGKIIDQPLITSKNNLYTAGQCTWYVFDKRAKDGHTISTFWGDAKNWAGQASSNGFKVDRHPTRGSILQTVNGPFGHVAYVEKVNIDGSILISEMNWIGEYIVSSRTISASEVSSYNYIH |
101. | MEVSSMKPYIQLVVFKQWLQYILLVTTIVIALVLIGIGYRVAHDNFKIPITIQDLDQTTASKSFVNKIKQSDYVTIKKVDEDESYIEDDVTKKEAILSMQIPKGFSQKLKENRLKETIQLYGRDDFIGGIAVEIVSSSLYEQQIPNIIYEHLEDMKQHQSIDAINKSYHKHTPESKIKFVSLTKQAQHSISISLIFAVILFVSAVQVVLHYRLNQQAALQRLSQYHLSRFKLYSTUVMTHTILLLLVLLAVSLYLSQPLSLIFYLKSLLLILIYEIGIVFILFHIQTISHRLFMTFIYALAMGIVYLIIFM |
102. | MIEVTEMNFFDIHKIPNKGIPLSVQRKLWLRNFMQAFFVVFFVYMAMYLIRNNFKAAQPFLKEEIGLSTLELGYIGLAFSITYGLGKTLLGYFVDGRNTKRIISFLLILSAITVLIMGFVLSYFGSVMGLLIVLWGLNGVFQSVGGPASYSTISRWAPRTKRGRYLGFWNTSHNIGGAIAGGVALWGANVFFHGNVIGMFIFPSVIALLIGIATLFIGKDDPEELGWNRAEEIWEEPVDKENIDSQGMTKWEIFKKYILGNPVIWILCVSNVFVYIVRIGIDNWAPLYVSEHLHFSKGDAVNTIFYFEIGALVASLLWGYVSDLLKGRRAIVAIGCMFMITFVVLFYTNATSVMMVNISLFALGALIFGPQLLIGVSLTGFVPKNAISVANGMTGSFAYLFGDSMAKVGLAAIADPTRNGLNIFGYTLSGWTDVFIVFYVALFLGMILLGIVAFYEEKKIRSLKI |
103. | MTKKKNILKAIGIYSFIAMMFVIILYPLLWTFGISLNPGTNLYGAKMIPDNATFKNYAFLLFDDSSQYLTWYKNTLIVASANALFSVIFVTLTAYAFSRYRFVGRKYGLITFLILQMFPVLMAMVAIYILLNTIGLLDSLFGLTLVYIGGSIPMNAFLVKGYFDTIPKELDESAKIDGAGHMRIFLQIMLPLAKPILAVVALFNFMGPFMDFILPKILLRSPEKFTLAVGLFNFINDKYANNFTVFAAGAIMIAVPIAIVFLFLQRYLVSGLTTGATKG |
104. | MMENSTTEARNEATMHLDEMTVEEALITMNKEDQQVPLAVRKAIPQLTKVIKKTIAQYKKGGRLIYIGAGTSGRLGVLDAAECVPTFNTDPHEIIGIIAGGQHAMTMAVEGAEDHKKLAEEDLKNIDLTSKDVVIGIAASGKTPYVIGGLTFANTIGATTVSISCNEHAVISEIAQYPVEVKVGPEVLTGSTRLKSGTAQKLILNMISTITMVGVGKVYDNLMIDVKATNQKLIDRSVRIIQEICAITYDEAMALYQVSEHDVKVATVMGMCGISKEEATRRLLNNGDIVKRAIRDRQP |
105. | LQYIIRYIMMTLQIHTGGINLKKKNIYSIRKLGVGIASVTLGTLLISGGVTPAANAAQHDEAQQNAFYQVLNMPNLNADQRNGFIQSLKDDPSQSANVLGEAQKLNDSQAPKADAQQNNFNKDQQSAFYEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNESQAPKADNNFNKEQQNAFYEILNMPNLNEEQRNGFIQSLKDDPSQSANLLSEAKKLNESQAPKADNKFNKEQQNAFYEILHLPNLNEEQRNGFIQSLKDDPSQSANLLAEAKKLNDAQAPKADNKFNDEQQNAFYEILHLPNLTEEQRNGFIQSLKDDPSVSKEILAEAKKLNDAQAPKEEDNNKPGKEDNNKPGKEDNNKPGKEDNNKPGKEDGNKPGKEDNKKPGKEDGNKPGKEDNKKPGKEDGNKPGKEDGNKPGKEDGNGVHVVKPGDTVNDIAKANGTTADKIAADNKLADKNMIKPGQELVVDKKQPANHADANKAQALPETGEENPFIGTTVFGGLSLALGAALLAGRRREL |
106. | MDKKSEKRGIKMTVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYRILKTMYVGGGTPTALSINQLERLLKAIRDTFTITGEYTFEANPDELTKEKVQLLEKYGVKRISMGVQTFKPELLSVLGRTHNTEDIYTSVLNAKNAGIKSISLDLMYHLPKQTIEDFEQSLDLALDMDIQHISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQYEISNFALDGHESEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKAILVSNKPSLTERMEEEMFLGLRLNEGVSSSRFKKKFDQSIESVFGQTINNLKEKELIVEKNDVIALTNRGKVIGNEVFEAFLIND |
107. | atgaatgtattagtaattggtgctggtggacgagaacatgcacttgcatataaacttaatcaatcgaatctagttaaacaagtgtttgtcattccaggtaatgaggcaatgacacctatagctgaagtacacactgaaatttcagaacctgatcatcaagcgatactagattttgctaaacggcaaaatgttgattgggtagttataggtccagaacagccgctaattgatggattagcagacattttacgagcgaatggtttcaaagtgtttggtccaaataagcaagcagctcaaatcgaaggctcaaaattatttgctaaaaagataatggaaaaatataatattccaactgctgattataaagaagttgagcgaaaaaaggatgctttaacatatattgaaaactgtgaattgcccgttgttgtcaagaaagatgggttagctgctgggaaaggcgttattattgcagatactattgaagcagccagaagtgctattgagattatgtatggtgatgaagaagaaggtactgttgtatttgaaacgtttttagaaggtgaagagttctcgctaatgacatttgttaatggtgatttagcagtacctttcgactgtattgcacaagatcataaacgcgcatttgatcatgatgaaggaccaaatactggtggtatgggggcttattgtccagtaccacatattagtgacgatgttttaaaacttacaaatgaaacaattgcacaacccattgcaaaggcaatgcttaatgaaggttatcaattcttcggtgtattatacattggtgctattttaactaaagatggtccaaaagtaatagaatttaatgcccgttttggtgatcctgaagctcaagtattattaagtcgcatggaaagtgatttaatgcagcatattattgatttagatgaaggaaaacgtactgaattcaaatggaaaaatgaatctattgtaggggtcatgttggcatcaaaaggatatcctgatgcatatgaaaaagggcataaagtaagtggctttgatttaaatgaaaactattttgttagtggattaaagaagcaaggtgatacctttgttacttcaggtggtagagttatacttgccatcggaaaaggtgacaatgtacaagatgcacagcgagacgcatacaaaaaagtatcacaaatacaaagtgaccatttattctatcgtcatgacattgcgaataaagcactacaacttaaa |
108 | MNVLVIGAGGREHALAYKLNQSNLVKQVFVIPGNEAMTPIAEVHTEISEPDHQAILDFAKRQNVDWVVIGPEQPLIDGLADILRANGFKVFGPNKQAAQIEGSKLFAKKIMEKYNIPTADYKEVERKKDALTYIENCELPVVVKKDGLAAGKGVIIADTIEAARSAIEIMYGDEEEGTVVFETFLEGEEFSLMTFVNGDLAVPFDCIAQDHKRAFDHDEGPNTGGMGAYCPVPHISDDVLKLTNETIAQPIAKAMLNEGYQFFGVLYIGAILTKDGPKVIEFNARFGDPEAQVLLSRMESDLMQHIIDLDEGKRTEFKWKNESIVGVMLASKGYPDAYEKGHKVSGFDLNENYFVSGLKKQGDTFVTSGGRVILAIGKGDNVQDAQRDAYKKVSQIQSDHLFYRHDIANKALQLK |
109. | atgcaaccacatttaatatgtctagacttagacggaacattattaaacgataacaaagaaatttcatcatatactaaacaagtattaaatgaattacaacaacgtggacaccaaattatgattgcgactggcagaccttatcgtgcaagtcaaatgtattatcatgaattaaatttaacgacaccaattgttaattttaatggcgcttacgtacatcaccctaaagataaaaacttcaaaacttgccatgaaattttagatttaggcatcgcacaaaacattattcaaggattacaacaatatcaagtatcgaatattatagcagaagtgaaagattatgttttcattaacaatcatgatccaagattatttgaaggtttttcaatgggtaatccaagaattcaaactggtaatttacttgtccacttgaaagaatcccctacctcaattttaattgaagccgaagaaagtaaaatacctgaaatcaaaaatatgcttactcatttttatgccgatcatattgagcatcgacgctggggcgcaccattccctgtcattgaaattgtaaaacttggtattaataaagcaagaggcattgagcaagttagacaatttttaaatattgaccgaaataatattattgcattcggtgatgaagataatgatattgaaatgattgagtacgcgcgtcacggtgttgctatggaaaatggtttgcaagaacttaaagatgtagcgaacaatattacattcaacaataatgaagatggcattggtcgatatttgaatgatttctttaatttaaatattagatattactgt |
110. | MQPHLICLDLDGTLLNDNKEISSYTKQVLNELQQRGHQIMIATGRPYRASQMYYHELNLTTPIVNFNGAYVHHPKDKNFKTCHEILDLGIAQNIIQGLQQYQVSNIIAEVKDYVFINNHDPRLFEGFSMGNPRIQTGNLLVHLKESPTSILIEAEESKIPEIKNMLTHFYADHIEHRRWGAPFPVIEIVKLGINKARGIGQVRQFLNIDRNNIIAFGDEDNDIEMIEYARHGVAMENGLQELKDVANNITFNNNEDGIGRYLNDFFNLNIRYYC |
111. | gtgaaaccaatggctaagtctaatagtaaagacatcgttttaattggagccggtgtacttagcacaacatttggttcaatgttaaaagaaattgagccagactggaatatccacgtttacgaacgcttggatcgtcctgcaatcgaaagttcaaacgaaagaaataatgctggtacgggtcatgcagcattatgtgagttgaactacacagttttacaacctgatggttctatcgacatcgaaaaagcgaaagtgattaacgaagagtttgagatttcaaaacaattctggggtcacttagtgaaaagcggtagcatcgagaacccaagagaatttatcaatccattaccacacatcagttatgttagaggtaaaaacaatgttaaattcttaaaagatcgttacgaagcgatgaaagctttccctatgttcgataatatcgaatatactgaagacatcgaagtaatgaaaaaatggattccattgatgatgaaaggccgtgaagataaccctggtatcatggcggcaagtaaaattgacgaaggtacagatgtaaacttcggtgaattaacacgtaaaatggctaaaagcattgaagcacatccaaatgctacagtgcaatttaaccatgaagttgttgattttgaacaattatcaaatggtcaatgggaagttactgttaaaaatcgcctaactggtgagaaattcaaacaagtaactgactacgtattcatcggtgctggcggtggagcaattccattattacaaaaaacaggtatccctgaaagtaaacatttgggtggattccctatcagtggtcaattcttagcttgtacaaacccacaagttattgaacaacacgatgccaaagtttatggtaaagagccacctggtacaccaccaatgactgtacctcatttagatacgcgttacattgatggtcaaagaacattattatttggaccatttgctaatgttggacctaaattcttgaaaaatggttctaacttagatttattcaagtctgttaaaacatacaacattacaactttattagcagcagcagttaaaaacttacctttaattaaatactcatttgaccaagtaattatgacaaaagaaggttgtatgaaccacttacgtactttctatccagaagcacgtaatgaagattggcaattatacactgctggtaaacgtgtacaagttatcaaagatacacctgaacacggtaaaggattcatccaattcggtacagaagtggttaactcacaagaccacactgtaattgcattattaggtgaatcaccaggggcttcaacttcagtttcagttgcgttagaagtattagaacgtaacttccctgaatacaaaactgaatgggcacctaaaattaagaaaatgattccatcatacggtgaatcattaattgaagacgaaaaattaatgagaaaaatccgtaaacaaacttcaaaagacttagaattaggttactacgaaaac |
112. | MKPMAKSNSKDIVLIGAGVLSTTFGSMLKEIEPDWNIHVYERLDRPAIESSNERNNAGTGHAALCELNYTVLQPDGSIDIEKAKVINEEFEISKQFWGHLVKSGSIENPREFINPLPHISYVRGKNNVKFLKDRYEAMKAPPMFDNIEYTEDIEVMKKWIPLMMKGREDNPGINAASKIDEGTDVNFGELTRKMAKSIEAHPNATVQFNHEVVDFEQLSNGQWEVTVKNRLTGEKFKQVTDYVFIGAGGGAIPLLQKTGIPESKHLGGFPISGQFLACTNPQVIEQHDAKVYGKEPPGTPPMTVPHIDTRYIDGQRTLLFGPFANVGPKFLKNGSNLDLFKSVKTYNITTLLAAAVKNLPLIKYSFDQVIMTKEGCMNHLRTFYPEARNEDWQLYTAGKRVQVIKDTPEHGKGFIQFGTEVVNSQDHTVIALLGESPGASTSVSVALEVLERNFPEYKTEWAPKIKKMIPSYGESLIEDEKLMRKIRKQTSKDLELGYYEN |
113. | atgctagaggcacaattttttactgatactggacaacatagagataagaatgaagatgcgggtggtattttttataatcaaactaatcaacaacttttagttctgtgtgatggtatgggtggccataaagcaggagaagttgcaagtaaatttgttacagatgagttgaaatcccgttttgaagcggaaaatcttatagaacaacatcaagctgaaaattggttgcgtaataatataaaagataataaattttcagttatatcactatgcacaagaaaatgcagatataaaggtatgggtacaacatgtgtttgtgcacttgtttttgaaaaatcagttgtgatagcaaatgtcggtgattctagagcctatgttattaatagtcgacaaattgaacaaattactagtgatcactcatttgttaatcatcttgttttaacgggtcaaattacgccggaagaagcatttacacatccacaacgtaatattattacgaaggtgatgggcacagataaacgtgtgagtccagatttgtttattaagcgattaaatttttatgattatttattattaaattcagatggattaactgattatgttaaagacaatgaaattaagcgtttgttagtaaaagaaggtacaatagaagatcatggtgatcaattaatgcaattggcattagataaccattcgaaagataacgttactttcatactcgcggctattgaaggtgataaagta |
114. | matdtghrdkndaggyntnvcdgmgghkagvaskvtdksranHanwrnnkdnvhyanaykgmgttcvcavksvvanvgdsravvnsrtsdhsvnhvtgtathrntkvmgtdkrvsdkrnvgynsggtgyvkgnkrvkgtgnggmagnnskdnvtaagdkv |
115. | atggcaaaagaaaaattcgatcgttctaaagaacatgccaatatcggtactatcggtcacgttgaccatggtaaaacaacattaacagcagcaatcgctactgtattagcaaaaaatggtgactcagttgcacaatcatatgacatgattgacaacgctccagaagaaaaagaacgtggtatcacaatcaatacttctcacattgagtaccaaactgacaaacgtcactacgctcacgttgactgcccaggacacgctgactacgttaaaaacatgatcactggtgctgctcaaatggacggcggtatcttagtagtatctgctgctgacggtccaatgccacaaactcgtgaacacattcttttatcacgtaacgttggtgtaccagcattagtagtattcttaaacaaagttgacatggttgacgatgaagaattattagaattagtagaaatggaagttcgtgacttattaagcgaatatgacttcccaggtgacgatgtacctgtaatcgctggttcagcattaaaagctttagaaggcgatgctcaatacgaagaaaaaatcttagaattaatggaagctgtagatacttacattccaactccagaacgtgattctgacaaaccattcatgatgccagttgaggacgtattctcaatcactggtcgtggtactgttgctacaggccgtgttgaacgtggtcaaatcaaagttggtgaagaagttgaaatcatcggtttacatgacacatctaaaacaactgttacaggtgttgaaatgttccgtaaattattagactacgctgaagctggtgacaacattggtgcattattacgtggtgttgctcgtgaagacgtacaacgtggtcaagtattagctgctcctggttcaattacaccacatactgaattcaaagcagaagtatacgtattatcaaaagacgaaggtggacgtcacactccattcttctcaaactatcgtccacaattctatttccgtactactgacgtaactggtgttgttcacttaccagaaggtactgaaatggtaatgcctggtgataacgttgaaatgacagtagaattaatcgctccaatcgcgattgaagacggtactcgtttctcaatccgtgaaggtggacgtactgtagggatcaggcgttgttactgaaatcattaaa |
116. | MAKEKFDRSKEHANIGTIGHVDHGKTTLTAAIATVLAKNGDSVAQSYDMIDNAPEEKERGITINTSHIEYQTDKRHYAHVDCPGHADYVKNMITGAAQMDGGILVVSAADGPMPQTREHILLSRNVGVPALVVFLNKKVVDMDDEELLLVEMEBTDLLSEYDFPGDDVPVIAGSALKALEGDAQYEEKILELMEAVDTYIPTPERDSDKPFMMPVEDVFSITGRGTVATGRVERGQIKVGEEVEIIGLHDTSKTTVTGVEMFRKLLDYAEAGDNIGALLRGVAREEIQRGQVLAAPGSITPHTEFKAEVYVLSKDEGGRHTPFFSNYRPQFYFRTTDVTGVVHLPEGTEMVMPGDNVEMTVELIAPIAIDEGTRFSIREGGRTVGSGVVTEITE |
117. | atgactaagagtgctttagtaacaggtgcatcaagaggaattggacgtagtattgcgttacaattagcagaagaaggatataatgtagcagtaaactatgcaggcagcaaagagaaagctgaagcagtagtcgaagaaatcaaagctaaaggtgttgaaagttttgcgattcaagcaaatgttgccgatgcatgaaaatgactaagagtgctttagtaacaggtgcatcaagaggaattggacgtagtattgcgttacaattagcagaagaaggatataatgtagcagtaaactatgcaggcagcaaagagaaagctgaagcagtagtcgaagaaatcaaagctaaaggtgttgaaagttttgcgattcaagcaaatgttgccgatgctgatgaagttaaagcaatgattaaagaagtagttagccaatttggttctttagatgttttagtaaataatgcaggtattactcgcgataatttattaatgcgtatgaaagaacaagagtgggatgatgttattgacacaaacttaaaaggtgtatttaactgtatccaaaaagcaacaccacaaatgttaagacaacgtagtggtgctatcatcaatttatcaagtgttgttggagcagtaggtaatccgggacaagcaaactatgttgcaacaaaagcaggtgttattggtttaactaaatctgcggcgcgtgaattagcatctcgtggtatcactgtaaatgcagttgcacctggttttattgtttctgatatgacagatgctttaagtgatgagcttaaagaacaaatgttgactcaaattccgttagcacgttttggtcaagacacagatattgctaatacagtagcgttcttagcatcagacaaagcaaaatatattacaggtcaaacaatccatgtaaatggtggaatgtacatg |
118. | MTKSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVESFAIQANVADADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKGVFNCIQKATPQMLRQRSGAIINLSSVVGAVGNPGQANYVATKAGVIGLTKSAARELASRGITVNAVAPGFIVSDMTDALSDELKEQMLTQIPLARFGQDTDIANTVAFLASDKAKYITGQTIHVNGGMYM |
119. | atgaaaatttctactaaagggagatatggacttacattgatgatttctcttgctaaaaaagaggggcaaggatgtatatcattaaagtcaattgctgaagaaaataatttgagtgatttatatttagaacagcttgtaggtcctttaagaaatgcggggttaattcgaagtgtacgcggtgctaaaggtggataccaattaagagtgccagcggaagaaatctcagcaggggatattataagactgttagaaggtccaattacatttgttgaaagtattgaatcagaaccacctgcgcaaaaacaactatggattcgcatgagagatgcagtgagagatgttttagataatacaacattgaaatatttagcggaatatgtagatacaagtgaagatttagacggatacatgttttatatt |
120. | MLKISTKGRYGLTIMIELAKKHGEGPTSLKSOAQTNNLSEHYLEQLVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISLLKCWKMRSLPSVSSGFASGML |
121. | gtggcatttgaatttagattacccgatatcggggaaggtatccacgaaggtgaaattgtaaaatggtttgttaaagctggagatactattgaagaagacgatgttttagctgaggtacaaaacgataaatcagtagtagaaatcccatcaccagtatctggtactgtagaagaagttatggtagaagaaggtacagtagctgtagttggtgacgttattgttaaaatcgatgcacctgatgcagaagatatgcaatttaaaggtcatgatgatgattcatcatctaaagaagaacctgcgaaagaggaagcgccagcagagcaagcacctgtagctactcaaactgaagaagtagatgaaaacagaactgttaaagcaatgccttcagtacgtaaatacgcacgtgaaaaaggtgttaacattaaagcagtttctggatctggtaaaaatggtcgtattacaaaagaagatgtagatgcatacttaaatggtggtgcaccaacagcttcaaatgaatcagctgcttcagctacaagtgaagaagttgctgaaactcctgcagcacctgcagcagtaacattagaaggcgacttcccagaaacaactgaaaaaatccctgctatgcgtagagcaattgcgaaagcaatggttaactctaagcatactgcacctcatgtaacattaatggatgaaattgatgttcaagcattatgggatcaccgtaagaaatttaaagaaatcgcagctgaacaaggtactaagttaacattcttaccttatgttgttaaagcacttgtttctgcattgaaaaaatacccagcacttaacacttcattcaatgaagaagctggtgaaatcgttcataaacattactggaatatcggtattgcagcagacactgatagaggattattagtacctgttgttaaacatgctgatcgtaagtctattttccaaatttcagatgaaattaatgaattagctgttaaagcacgtgatggtaaattaacagccgatgaaatgaaaggtgctacatgcacaatcagtaatatcggttcagctggtggacaatggttcactccagttatcaatcacccagaagtagcaatcttaggaattggccgtattgctcaaaaacctatcgttaaagatggagaaattgttgcagcaccagtattagcattatcattaagctttgaccacagacaaattgatggtgcaactggccaaaatgcaatgaatcacattaaacgtttattaaataatccagaattattattaatggagggg |
122. | MAFEFRLPDIGEGIHEGEIVKWFVKAGDTIEEDDVLAEVQNDKSVVEIPSPVSGTVEEVMVEEGTVAVVGDVIVKIDAPDAEDMQFKGHDDDSSSKEEPAKEEAPAEQAPVATQTEEVDENRTVKAMPSVRKYAREKGVNIKAVSGSGKNGRITKEDVDAYLNGGAPTASNESAASATSEEVAETPAAPAAVTLEGDFPETTEKIPAMRRAIAKAMVNSKHTAPHVTLMDEIDVQALWDHRKKFKEIAAEQGTKLTFLPYVVKALVSALKKYPALNTSFNEEAGEIVHKHYWNIGLAADTDRGLLVPVVKHADRKSIFQISDEINELAVKARDGKLTAEEMKGATCTISNIGSAGGQWFTPVINHPEVAILGIGRIAQKPIVKDGEIVAAPVLALSLSFDHRQIDGATGQNAMNHIKRLL |
123. | atgctaaacagagaaaataaaacggcaataacaaggaaaggcatggtatccaatcgattaaataaattttcgattagaaagtacacagtgggaacagcatcaattttagtaggtacaacattaatttttggtctggggaaccaagaagcaaaggctgcagaaagtactaataaagaattgaacgaagcgacaacttcagcaagtgacaatcaatcgagtgataaagttgatatgcagcaactaaatcaagaagacaatactaaaaatgataatcaaaaagaaatggtatcatctcaaggtaatgaaacgacttcaaatgggaataaattaatagaaaaagaaagtgtacaatctaccactggaaataaagttgaagtttcaactgccaaatcagatgagcaagcttcaccaaaatctacgaatgaagatttaaacactaaacaaactataagtaatcaagaagcgttacaacctgatttgcaagagaataaatcagtggtaaatgttcaaccaactaatgaggaaaacaaaaaggtagatgccaaaactgaatcaactacattaaatgttaaaagtgatgctatcaagagtaatgatgaaactcttgttgataacaatagtaattcaaataatgaaaataatgcagatatcattttgccaaaaagtacagcacctaaacgtttgaatacaagaatgcgtatagcagcagtacagccatcatcaacagaggctaaaaatgttaatgatttaatcacatcaaatacaacattaactgtcgttgatgcagataaaaacaataaaatcgtaccagcccaagattatttatcattaaaatcacaaattacagttgatgacaaagttaaatcaggtgattatttcacaattaaatactcagatacagtacaagtatatggattgaatccggaagatattaaaaatattggtgatattaaagatccaaataatggtgaaacaattgcgactgcaaaacatgatactgcaaataatttaattacatatacatttacagattatgttgatcgatttaattctgtacaaatgggaattaattattcaatttatatggatgctgatacaattcctgttagtaaaaacgatgttgagtttaatgttacgataggtaatactacaacaaaaacaactgctaacattcaatatccagattatgttgtaaatgagaaaaattcaattggatcagcgttcactgaaacagtttcacatgttggaaataaagaaaatccagggtactataaacaaacgatttatgtaaatccatcggaaaattctttaacaaatgccaaactaaaagttcaagcttaccactcaagttatcctaataatatcgggcaaataaataaagatgtaacagatataaaaatatatcaagttcctaaaggttatacattaaataaaggatacgatgtgaatactaaagagcttacagatgtaacaaatcaatacttgcagaaaattacatatggcgacaacaatagcgctgttgattgattttggaatgcagattctgcttatgttgtaatggttaatacaaaattccaatatacaaatagcgaaagcccaacacttgttcaaatggctactttatcttcaacaggtaataaatccgtttctactggcaatgctttaggatttactaataaccaaagtggcggagctggtcaagaagtatataaaattggtaactacgtatgggaagatactaataaaaacggatgttcagaattaggagaaaaaggcgttggcaatgtaactgtaactgtatttgataataatacaaatacaaaagtaggagaagcagttactaaagaagatgggtcatacttgattccaaacttacctaatggagattaccgtgtagaattttcaaacttaccaaaaggttatgaagtaaccccttcaaaacaaggtaataacgaagaattagattcaaacggcttatcttcagttattacagttaatggcaaagataacttatctgcagacttaggtatttacaaacctaaatacaacttaggtgactatgtctgggaagatacaaataaaaatggtatccaagaccaagatgaaaaaggtatatctggcgtaacggtaacattaaaagatgaaaacggtaacgtgttaaaaacagttacaacagacgctgatggcaaatataaatttactgatttagataatggtaattataaagttgaatttactacaccagaaggctatacaccgactacagtaacatctggtagcgacattgaaaaagactctaatggtttaacaacaacaggtgttattaatggtgctgataacatgacattagatagtggattctacaaaacaccaaaatataatttaggtaattatgtatgggaagatacaaataaagatggtaagcaggattcaactgaaaaaggtatttcaggcgtaacagttacattgaaaaatgaaaacggtgaagttttacaaacaactaaaacagataaagatggtaaatatcaatttactggattagaaaatggaacttataaagttgaattcgaaacaccatcaggttacacaccaacacaagtaggttcaggaactgatgaaggtatagattcaaatggtacatcaacaacaggtgtcattaaagataaagataacgatactattgactctggtttctacaaaccgacttacaacttaggtgactatgtatgggaagatacaaataaaaacggtgttcaagataaagatgaaaagggcatttcaggtgtaacagttacgttaaaagatgaaaacgacaaagttttaaaaacagttacaacagatgaaaatggtaaatatcaattcactgatttaaacaatggaacttataaagttgaattcgagacaccatcaggttatacaccaacttcagtaacttctggaaatgatactgaaaaagattctaatggtttaacaacaacaggtgtcattaaagatgcagataacatgacattagacagtggtttctataaaacaccaaaatatagtttaggtgattatgtttggtacgacagtaataaagacggcaaacaagattcaactgaaaaaggtatcaaaagatttaaagttactttattaaatgaaaaaggcgaagtaattggaacaactaaaacagatgaaaatggtaaatactgctttgataatttagatagcggtaaatacaaagttatttttgaaaagcctgctggcttaacacaaacaggtacaaatacaactgaagatgataaagatgcagatggtggcgaagttgacgtaacaattacggatcatgatgatttcacacttgataatggctactacgaagaagaaacatcagatagcgactcagattcggacagcgactcagattcagacagagactcagactcagatagtgattcagactcggatagcgattcagattcagacagcgattcagattcagatagcgattcagattcagacagagactcagatagtgattcagactcagatagcgactcagattcagacagcgactcagattcagacagcgactcagactcagatagtgattcagactcagatagcgactcagattcagacagcgactcagactcagacagcgactcagactcagatagtgactcagattcagatagcgactcagattcggacagcgattcagactcagatagcgactcagattcagatagcgattcggactcagatagcgactcagattcagatagtgattcagactcagatagcgactcagattcagacagcgactcagattcggatagcgactcagattcagacagcgactcagactcggatagtgattcagactcagatagcgactcagactcagatagcgattcagattcagatagcgactcagactcagacagcgattcagactcagacagcgactcagactcagatgcaggtaagcacacacctgttaaaccaatgagtactactaaagaccatcacaataaagcaaaagcattaccagaaacaggtaatgaaaatagcggctcaaataacgcaacgttatttggcggattattcgaagcattaggatcattattgttattcggtcgtcgtaaaaaacaaaataaa |
124. | MLNRENKTAITRKGNVSNRLNKFSIRKYTVGTASILVGTTLIFGLGNQEAKAAESTNKELNEATTSASDNQSSDKVDNQQLNQEDNTKNDNQKEMVSSQGNETTSNGNKLIEKESVQSTTGNKVEVSTAKSDEQASPKSTNEDLNTKQTISNQEALQPDLQENKSVVNVQPTNEENKKVDAKTESTTLNVKSDAIKSNDETLVDNNSNSNNKNNADIILPKSTAPKRLNTRMRTAAVQPSSTEAKNVNDLITSNTTLTVVDADKNNKIVPAQDYLSLKSQITVDDKVKSGDYFTIKYSDTVQVYGLNPEDIKNIGDIKDPNNGETIATAKHDTANNLITYTFTDYVDRFNSVQMGINYSIYMDADTIPVSKNDVEFNVTIGNTTTKTTANIQYPDYVVNEKNSIGSAFTETVSHVGNKENPGYYKQTIYVNPSENSLTNAKLKVQAYHSSYPNNIGQINKDVTDIKIYQVPKGYTLNKGYDVNTKELTDVTNQYLQKITYGDNSAVIDFGNADSAYVVMVNTKFQYTNSESPTLVVQMATLSSTGNKSVSTGNALGFTNNQSGGAGQEVYKIGNYVWEDTNKNGVQELGEKGVGNVTVTVFDNNTNTKVGEAVTKEDGSYLIPNLPNGDYRVEFSNLPKGYEVTPSKQGNNEELDSNGLSSVITVNGKDNLSADLGIYKPKYNLGDYVWEDTNKNGIQDQDEKGISGVTVTLKDENGNVLKTVTTDADGKYKFTDLDNGNYKVEFTTPEGYTPTTVTSGSDIEKDSNGLTTTGVINGADNMTLDSGFYKTPKYNLGNYVWEDTNKDGKQDSTEKGISGVTVTLKNENGEVLQTTKTDKDGKYQFTGLENGTYKVEFETPSQYTPTQVGSGTDEGIDSNGTSTTGVIKDKDNDTIDSGFYKPTYNLGDYVWEDTNKNGVQDKDEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNGTYKVEFETPSGYTPTSVTSGNDTEKDSNGLTTTGVIKDADNNTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDVKVTLLNELGEVIGTTKTDENGKYCFDNLDSGKYKVIFEKPAGLTQTGTNTTEDDKDADGGEVDVTTTDHDDFTLDNGYYEEETSDSDSDSDSDSDSDRDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGNENSGSNNATLFGGLFAALGSLLLFGRRKKQNK |
125. | ttggcaggtcaagttgtccaatatggaagacatcgtaaacgtagaaactacgcgagaatttcagaagtattagaattaccaaacttaatagaaattcaaactaaatcttacgagtggttcctaagagaggtttaatcgaaatgttttagagacatttctccaattgaagattttactggtaatttgtcattagagtttgtggattaccgtttaggagaaccaaaatatgatttagaagaatctaaaaaccgtgacgctacttatgctgcacctcttcgtgtaaaagtgcgtctaatcattaaagaaacaggagaagttaaagaacaagaagtctttatgggtgatttcccattaatgactgatacaggtacgttcgttatcaatggtgcagaacgtgtaatcgtatctcaattagttcgttcaccatccgtttatttcaatgaaaaaatcgacaaaaatggtcgtgaaaactatgatgcaacaattattccaaaccgtggtgcatggttagaatatgaaacagatgctaaagatgttgtatacgtacgtattgatagaacacgtaaactaccattaacagtattgttacgtgcattaggtttctcaagcgaccaagaaattgttgaccttttaggtgacaatgaatatttacgatatactttagagaaagacggcactgaaaacactgaacaagcgttattagaaatctatgaacgtttacgtccaggtgaaccaccaactgttgaaaatgctaaaagtctattgtattcacgtttctttgatccaaaacgctatgacttagcaagcgtgggtcgttataaaacaaacaaaaaattacatttaaaacatcgtttatttaatcaaaaattagctgagccaattgtaaatactgaaactggtgaaattgtagttgaagaaggtacagtgcttgatcgtcgtaaaatcgacgaaatcatggatgtacttgaatcaaatgcaaacagcgaagtgtttgaattcatggtagcgttataagacgagccagtagaaattcaatcaattaaagtatatgttcctaacgatgatgaaggtcgtacgacaactgtaattggtaatgctttccctgactcagaagttaaatgcattacaccagcagatatcattgcttcaatgagttacttctttaacttattaagcggtattggatatacagatgatattgaccatttaggtaaccgtcgtttacgttctgtaggtgaattactacaaaaccaattccgtatcggtttatcaagaatggaaagagttgtacgtgaaagaatgtcaattcaagatactgagtctatcacacctcaacaattaattaatattcgacctgttattgcatctattaaagaattctttggtagctctcaattatcacaattcatggaccaagcaaacccattagctgagttaacgcataaacgtcgtctatcagcattaggacctggtggtttaacacgtgcccgtgctcaaatggaagtacgtgacgttcactactctcactatggccgtatgtgtccaattgaaacacctgagggaccaaacattggattgattaactcattatcaagttatgcacgtgtaaatgaattcggctttattgaaacaccatatcgtaaagttgatttagatacacatgctatcactgatcaaattgactatttaacagctgacgaagaagatagctatgttgtagcacaagcaaactctaaattagatgaaaacggtcgtttcatggatgatgaagttgtatgtcgtttccgtggtaacaatacagttatggctaaagaaaaaatggattatatggatgtatcgccgaagcaagttgtttcagcagcgacagcatgtattccattcttagaaaatgatgactcaaaccgtgcattgatgggtgcgaacatgcaacgtcaagcagtgcctttgatgaatccagaagcaccatttgttggtacaggtatggaacacgttgcagcacgtgattctggtgcggctattacagctaagcacagaggtcgtgttgaacatgttgaatctaatgaaattcttgttcgtcgtctagttgaagagaacggcgttgagcatgaaggtgaattagatcgctatccattagctaaatttaaacgttcaaactcaggtacatgttacaaccaacgtccaatcgttgcagttggagatgttgttgagtataacgagattttagcagatggaccatctatggaattaggagaaatggcattaggtagaaacgtagtagttggtttcatgacttgggacggttacaactatgaggatgccgttatcatgagtgaaagacttgtgaaagatgacgtgtatacttctattcatattgaagagtatgaatcagaagtacgtgatactaagttaggacctgaagaaatcacaagagatattcctaatgtttctgaaagtgcacttaagaacttagacgatcgtggtatcgtttatattggtgcagaagtaaaagatggagatattttagttggtaaagtaacgcctaaaggtgtaactgagttaactgccgaagaaagattgttacatgcaatctttggtgaaaaagcacgtgaagttagagatactttattacgtgtacctcacggcgctggcggtatcgttcttgatgtaaaagtattcaatcgtgaagaaggcgacgatacattatcacctggtgtaaaccaattagtacgtgtatatatcgttcaaaaacgtaaaattcatgttggtgataagatgtgtggtcgacatggtaacaaaggtgtcatttctaagattgttcctgaagaagatatgccttacttaccagatggacgtccgatcgatatcatgttaaatcctcttggtgtaccatctcgtatgaacatcggacaagtattagagctacacttaggtatggctgctaaaaatcttggtattcacgttgcatcaccagtatttgacggtgcaaacgatgacgatgtatggtcaacaattgaagaagctggtatggctcgtgatggtaaaactgtactttatgatggacgtacaggtgaaccattcgataaccgtatttcagtaggtgtaatgtacatgttgaaacttgcgcacatggttgatgataaattacatgcgcgttcaacaggaccatattcacttgttacacaacaaccacttggcggtaaagcgcaattcggtggacaacgttttggtgagatggaggtatgggcacttgaagcatatggtgctgcatacacattacaagaaatcttaacttacaaatccgatgatacagtaggacgtgtgaaaacatacgaggctattgttaaaggtgaaaacatctctagaccaagtgttccagaatcattccgagtattgatgaaagaattacaaagtttaggtttagatgtaaaagttatggatgagcaagataatgaaatcgaaatgacagacgttgatgacgatgatgttgtagaacgcaaagtagatttacaacaaaatgatgctcctgaaacacaaaaagaagttactgat |
126. | MAGQVVQYGRHRKRRNYARISEVLELPNLIEIQTKSYEWFLREGLIEMFRDISPIEDFTGNLSLEFVDYRLGEPKYDLEESKNRDATYAAPLRVKVRLIIKETGEVKEQEVFNGDFPLMTDTGTEVINGAERVIVSQLVRSPSVYFNEKIDKNGRENYDATIIPNRGAWLEYETDAKDVVYVRIDRTRKLPLTVLLRALGFSSDQEIVDLLGDNEYLRNTLEKDGTENTEQALLEIYERLRPGEPPTVENAKSLLYSRFFDPKRYDLASVGRYKTNKKLHLKHRLFNQKLAEPIVNTETGEIVVEEGTVLDRRKIDEIMDVLESNANSEVFELHGSVIDEPVEIQSIKVYVPNDDEGRTTTVIGNAFPDSEVKCITPADILASNSYFFNLLSGIGYTDDIDHLQNRRLRSVGRLLQNQFRIGLSRMERVVRERMSIQDTESITPQQLINIRPVIASIKRFFPSSQLSQFNDQANPLAELTHKRRLSALGPGGLTRERAQMEVRDVHYSHYQRMCPIETPEGPNIGLINSLSSYARVNEFGFIETPYRKVDLDTHAITDQIDYLTADEEDSYVVAQANSKLDENGRFMDDEVVCRFRGNNTVMAKEKMDYMDVSPKQVVSAATACIPFLENDDSNRALMGANNQRQAVPLMNPEAPFVGTGMEHVAARDSGAAITAKHRGRVEHVESNEILVRRLVEENGVEHEGELDRYPLAKFKRSNSGTCYNQRPIVAVGDVVEYNEILADGPSMELGEMALGRNVVVGFNTWDGYNYEDAVIMSERLVKDDVYTSIHIEEYESRRQRDTKLGPEEITRDIPNVSESALKNLDDRGIVYIGAEVKDGDILVGKVTPKGVTELTAEERLLHAIFGEKAREVRDTSLRVPHGAGGIVLDVKVFNREEGDDTLSPGVNQLVRVYIVQKRKIHVGDKMCGRHGNKGVISKIVPEEDMPYLPDGRPIDIMLNPLGVPSRMNIGQVLELHLGMAAKNLGIHVASPVFDGANDDDVWSTIEEAGMARDGKTVLYDGRTGEPFDNRISVGVMYMLKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTYKSDDTVGRVKTYRAIVKGENISRPSVPESFRVLMKELQSLGLDVKVMDEQDNEIEMTDVDDDDVVERKVDLQQNDAPETQKSY |
127. | atgcttagggcatcgccatatctatcgtatttattcagtaatataaactggaaggagaaaaaatacatggctagagaattttcattagaaaaaactcgtaatatcggtatcatggctcacattgatgctggtaaaacgactacgactgaacgtattctttattacactggccgtatccacaaaattggtgaaacacacgaaggtgcttcacaaatggactggatggagcaagaacaagaccgtggtattactatcacatctgctgcaacaacagcagcttgggaaggtcaccgtgtaaacattatcgatacacctggacacgtagacttcactgtagaagttgaacgttcattacgtgtacttgacggagcagttacagtacttgatgcacaatcaggtgttgaacctcaaactgaaacagtttggcgtcaggctacaacttatggtgttccacgtatcgtatttgtaaacaaaatggacaaattaggtgctaacttcgaatactctgtaagtacattacatgatcgtttacaagctaacgctgctccaatccaattaccaattggtgcggaagacgaattcgaagcaatcattgacttagttgaaatgaaatgtttcaaatatacaaatgatttaggtactgaaattgaagaaattgaaattcctgaagaccacttagatagagctgaagaagctcgtgctagcttaatcgaagcagttgcagaaactagcgacgaattaatggaaaaatatcttggtgacgaagaaatttcagtttctgaattaaaagaagctatccgccaagctactactaacgtagaattctacccagtactttgtggtacagctttcaaaaacaaaggtgttcaattaatgcttgacgctgtaattgattacttaccttcaccactagacgttaaaccaattattggtcaccgtgctagcaaccctgaagaagaagtaatcgcgaaagcagacgattcagctgaattcgctgcattagcgttcaaagttatgactgacccttatgttggtaaattaacattcttccgtgtgtattcaggtacaatgacatctggttcatacgttaagaactctactaaaggtaaacgtgaacgtgtaggtcgtttattacaaatgcacgctaactcacgtcaagaaatcgatactgtatactctggagatatcgctgctgcggtaggtcttaaagatacaggtactggtgatactttatgtggtgagaaaaatgacattatcttggaatcaatggaattcccagagccagttattcacttatcagtagagccaaaatctaaagctgaccaagataaaatgactcaagctttagttaaattacaagaagaagacccaacattccatgcacacactgacgaagaaactggacaagttatcatcggtggtatgggtgagcttcacttagacatcttagtagaccgtatgaagaaagaattcaacgttgaatgtaacgtaggtgctccaatggtttcatatcgtgaaacattcaaatcatctgcacaagttcaaggtaaattctctcgtcaatctggtggtcgtggtcaatacggtgatgttcacattgaattcacaccaaacgaaacaggcgcaggtttcgaattcgaaaacgctatcgttggtggtgtagttcctcgtgaatacattccatcagtagaagctggtcttaaagatgctatggaaaatggtgttttagcaggttatcctttaattgatgttaaagctaaattatatgatggttcataccatgatgtcgattcatctgaaatggccttcaaaattgctgcatcattagcacttaaagaagctgctaaaaaatgtgatcctgtaatcttagaaccaatgatgaaagtaactattgaaatgcctgaagagtacatgggtgatatcatgggtgacgtaacatctcgtcgtggacgtgttgatggtatggaacctcgtggtaatgcacaagttgttaatgcttatgtaccactttcagaaatgttcggttatgcaacatcattacgttcaaacactcaaggtcgcggtacttacactatgtacttcgatcactatgctgaagttccaaaatcaatcgctgaagatattatcaagaaaaataaaggtgaa |
128. | MAREFSLEKTRNIGIMAHIDAGKTTTTERILYYTGRIHKIGETHEGASQMDWMEQEQDRGITITSAATTAAWEGHRVNIIDTPGHVDFTVEVERSLRVLDGAVTVLDAQSGVEPQTTEVWRQATTYGVPRIVFVNKMDKLGANFEYSVSTLHDRLQANAAPIQLPIGAEDEFRAIIDLVEMKCFKYTNDLGTEIEEIEIPEDHLDRAEEARASLIEAVAETSDELMRKYLGDEEISVSELKEAIRQATTNVEFYPVLCGTAFKNKGVQLMLDAVIDYLPSPLDVKPIIGHRASNPEEEVIAKADDSAEFAALAFKVMTDPYVGKLTFFRVYSGTMTSGSYVKNSTKGKRERVGRLLQMHANSRQEIDTVYSGDLAAAVGLKDTGTGDTLCGERNDIILESMEFPEPVIHLSVEPKSKADQDKMTQALVKLQEEDPTFHAHTDEETGQVIIGGMGELHLDILVDRMRKEFNVECNVGAPMVSYRETFKSSAQVQGKFSRQSGGRGQYGDVHIEFTPNETGAGFEFENAIVGGVVPREYIPSVEAGLKDAMENGVLAGYPLIDVKAKLYDGSYHDVDSSEMAFKIAASLALKEAAKKCDPVILEPMMKVTIEMPEEYMGDIMGDVTSRRGRVDGMEPRGNAQVVNAYVPLSEMFGYATSLRSNTQGRGTYTMYFDHYAEVPKSIAEDIIKKNKEG |
129. | atgactaaaaaagtagcaattattctagcaaacgaatttgaagatatagaatattcaagccctaaagaggcattagagaatgcaggctttaatactgtagtgattggagatactgcaaatagtgaagttgttggtaaacacggtgaaaaagttactgtcgatgtaggcattgcagaagctaaaccagaagattatgatgcattattaattcctggaggattttcaccagatcatttacgtggagatacagaaggtcgatatggcacatttgctaaatactttactaaaaatgatgtaccaacatttgccatttgtcatgggccacaaatactaatagatacagacgatttaaaaggtcgtacgttaacagcagtattaaatgtacgcaaagatttatcaaatgcaggcgcacatgtagttgatgagtcagtagttgtagacaacaatattgtaacaagtcgagtaccagacgatttagatgattttaatcgagaaatcgttaaacaattacaa |
130. | MTKKVAIILANEFEDIEYSSPKEALENAGFNTVVIGDTANSEVVGKHGEKVTVDVGIAEAKPEDYDALLIPGGFSPDHLRGDTEGRYGTFAKYFTKNDDPTFAICHGPQILIDTDDLKGATLTAVLNVRRDDLSNAGAHVVDESVVVDNIVTSRVPDDLDDFNREIVKQLQ |
131. | atggctaatcatgaacaaatcattgaagcgattaaagaaatgtcagtattagaattaaacgacttagtaaaagcaattgaagaagaatttggtgtaactgcagctgctccagtagcagtagcaggtgcagctggtggcgctgacgctgcagcagaaaaaactgaatttgacgttgagttaacttcagctggttcatctaaaatcaaagttgttaaagctgttaaagaagcaactggtttaggattaaaagatgctaaagaattagtagacggagctcctaaagtaatcaaagaagctttacctaaagaagaagctgaaaaacttaaagaacaattagaagaagttggagctactgtagaattaaaa |
132. | MANHEQIIEAIKEMSVLRLNDLVKAIEEEFGVTAAAPVAVAGAAGGADAAAEKTEFDVELTSAGSSKIKVVKAVKEATGLGLKDAKELVDGAPKVTKEALPKEEAEELKFQLEEVGATVELK |
133. | gtggaattacaattagcaattgatttattaaacaaagaagacgcggctgagttagcaaataaagtaaaagattatgtagatatcgtagaaatcggtacgccaatcatttacaacgaaggtttaccagcagttaaacatatggcagacaacattagtaatgtaaaagtattagcagacatgaaaattatggatgcagctgattatgaagttagccaagcaattaaatttggcgcggatgtaattacaatactaggtgttgcagaagatgcatcaattaaagcagctattgaagaagctcataaaaataataaacaattactagttgatatgattgctgttcaagatttagaaaaacgtgcaaaagaactagatgaaatgggtgctgattatattgcagtacacactggttatgatttacaagcagaagggcaatcaccattagaaagtttaagaaccgttaaatctgttattaaaaattctaaagttgcagtagcaggtggaattaaaccagatacaattaaagatattgtcgctgaaagtcctgatcttgttattgttggtggcggaatcgcaaatgcagatgatccagtagaagctgcaaaacaatgtcgcgctgcaatcgaaggtaag |
134. | MKLQLAIDLLNKEDAAELANKVKDYVDIVEIGTPIIYNEGLPAVKHMADNISNVKVLADMKIMDAADYEVSQAIKFGADVITILGAAEDASIKAAIEEAHKNNKQLLVDMIAVQDLEKRAKELDEMGADYIAVHTGYDLQAEGQSPLESLRTVKSVIKNSKVAVAGGIKPDTIKDIVAESPDLVIVGGGIANADDPVEAAKQCRAAIEGK |
135. | atgaaaaaattagtacctttattattagccttattacttctagttgctgcatgtggtactggtggtaaacaaagcagtgataagtcaaatggcaaattaaaagtagtaacgacgaattcaattttatatgatatggctaaaaatgttggtggagacaacgtcgatattcatagtattgtacctgttggtcaagatcctcatgaatatgaagttaaacctaaagatattaaaaagttaactgacgctgacgttattttatacaacggattaaatttagagactggtaacggttggtttgaaaaagccttagaacaggctggtaaatcattaaaagataaaaaagttatcgcagtatcaaaagatgttaaacctatctatttaaacggtgaagaaggcaacaaagataaacaagatccacacgcatggttaagtttagataacggtattaaatacgtaaaaacaattcaacaaacatttatcgataacgacaaaaaacataaagcagattatgaaaagcaaggtaacaaatacattgctcaattggaaaaattaaataatgacagtaaagacaaatttaatgacattccaaaagaacaacgtgccatgattacaagtgaaggtgccttcaagtacttctcaaaacaatacggtattacaccaggttatatttgggaaattaacactgaaaaacaaggtacacctgaacaaatgagacaagctattgagtttgttaaaaagcacaaattaaaacacttattagtagaaacaagtgttgataagaaagcaatggaaagtttatctgaagaaacgaagaaagatatctttggtgaagtgtacacagattcaatcggtaaagaaggcactaaaggtgactcttactacaaaatgatgaaatcaaatattgaaactgtacacggaagcatgaaa |
136. | MKKLLVPLLLALLLVAACGTGGKQSSDKSGKLKKVVTTNSILYDMAKNVGGDNVDIHSIVPVGQDPHKYEVKPKDIKKLTDADVILYNGLNLETGNGWFEKALEQAGKSLKDKKVIAVSKDVKPIYLNGEEGNKDKQDPHAWLSLDNGIKYVKTIOOTFIDNDKKHKADYEKQGNKYIAQLEKLNNDSKDKFNDIPKEQRAMITSEGAFKYFSKQYGITPGYIWEINTEKQGTPEQMRQAIEFVKKHKLKHLLVETSVDKKAMESLSEETKKDIFGEVYTDSIGKEGTKGDSYYKMMKSNIETVHGSMK |
137. | atgacaactgatattttgaacatttctgaagaacaacttgttgattattctaaagcccacaatgaaccttcttggatgacagaattacgtaaaaaagctttgaaattaacagaaactttagaaatgccaaaacctgataaaacaaaattaagaaaatgggattttgattcttttaaacaacacgatgtaaaaggtgatgtttatcaatctttatcacaattacctgagtcagtaagagaaattattgacgtagatcattctaaaaacttagtaattcaacataataatacgattgcgtacacacaagttgatgataatgcatcgaaagatggcgttatcgttgaaggtttagcagacgctcttatgaaccatagtgatttaagtacaaagtactttatgaaagatgcagtaacagtagatgaacatcgtatcacagcgctacacacggcattagttaatggtggcgtatttgtttatgttcctaaaaatgtagttgtagaacatccagtacaatacgttgtgttgcacgacgacgaaaatgcaagcttttataaccatgttatcatcgttactgaagaaagcgccgaagtcacatatgttgaaaattacttatcaaatgcatctggtgaaggaaatcaattaaatattatttctgaagtgattgctggtgcaaattcaaatatcacatatggctcagtggactatatggataaaggctttacaggtcatatcattcgacgtggtattactgaagcggatgcctcaattaattgggcactaggtttaatgaatgagggtagccaaattattgataatacaacaaatttatttggtgatcgttcaacaagttcacttaaatcagtagttgtaggtacaggcgaacaaaaaattaatctaacatctaaaatcgtacaatatggtaaagaaacagatggttatatccttaaacatggtgttatgaaagaacatgcatcgtctgtatttaatggtatcggctacattaagcatggtggaactaaatcaattgctaatcaggaatcacgtgtattaatgttatctgaacatgctcgtggtgacgcgaatcctattttattaattgatgaagatgatgtacaagctggtcatgctgcatcagtaggtcgtgttgatccagatcaactttactatttaatgagtcgtggtatttctcaaagagaagcggaacgtcttgttatacatggtttcttagatccagtagtacgtgaattacctatcgaagacgttaaacgtcaattgagagaagtaattgaacgcaaagtttctaaa |
138. | MTTDILNISEEQLVDYSKAHNEPSWMTELRKKALKLTETLEMPKPDKTKLRKWDFDSFKQHDVKGDVYQSLSQLPESVREIIDVDHSKNLVIQHNNTIAYTQVDDNASKDGVIVEGLADALMNHSDLVQKYFMKDAVTVDEHRITALHTALVNGGVFVYVPNVVVEHPVQYQVVLHDDENASFYNHVIIVTEESAEVTYVENYLSNASGEGNQLNIISEVIAGANSNITYGSVDYMDKGFTGHIIRRGITEADASINWALGIMNEGSQIIDNTTNLFGDRSTSSLKSVVVGTGEQKINLTSKIVQYGKETDGYILKHGVMKEHASSVFNGIGYIKHGGTKSIANQESRVLMLSEHARGDANPILLIDEDDVQAGHAASVGRVDPDQLYYLMSRGISQREAERLVIHGFLDPVVRELPIEDVKRQLREVIERKVSK |
139. | gtggttcaagaatatgatgtaatcgttataggtgcgggacatgcaggtgtagaagcaggtttagcatctgcaagacgtggtgctaaaacattaatgctaacaataaatttagataatattgcatttatgccatgtaacccatctgtaggtggaccagctaaaggtatcgttgttcgtgaaattgatgctttaggtggacaaatggcaaaaacaatcgataaaacacacattcaaatgagaatgttaaatacaggtaaaggacctgctgtaagagcactaagagcgcaagcagataaagtactttatcaacaagaaatgaaacgcgtgattgaagatgaagaaaatttgcatataatgcaaggtatggtagacgaacttattatagaagataatgaagttaaaggtgtacgtacaaatattggtacagagtatttatctaaagcagtaattattacaacgggaacatttttacgtggtgaaatcattttaggtaatatgaagtattcaagtggaccaaatcaccaattaccatcaatcacattatcagacaatttaagagaacttggttttgatattgttcgttttaaaacaggtacaccaccgcgtgtaaattcaaaaacaattgactattcgaagactgaaatacaaccaggtgacgatgtaggtcgtgcattcagctttgaaacaacagaatatatattagatcaattgccatgttggctaacgtatactaatgctgaaacacacaaagttatcgatgataatttacatctatctgcaatgtattcagggatgattaaaggaaccgggcaacgttattgcccttcaattgaagataaatttgttcgatttaatgataagccgcgacatcaacttttcttagagcctgaaggtcgtaatacaaatgaagtatatgtgcaaggattgtctacaagtcttcctgaacatgtgcaacgtcaaatgttagagacgataccaggtcttgaaaaagcagatatgatgcgtgccggctacgcaattgaatatgatgcgattgtgccaacgcagttatggcctacacttgaaacgaaaatgattaaaaacttatatactgcaggtcaaattaatggtacatctggttatgaagaagcagcaggacaaggattgatggcaggtattaacgctgcaggtaaagtgttaaacacaggcgaaaagatattaagtcgttcagatgcatatattggtgtcttaatcgatgatcttgtaactaaaggtactaatgaaccttatcgtttactaacatcacgtgcagaatatcgtttgttactacgtcatgataatgctgatttgagattgacggatatgggatatgaacttggtatgatttctgaagaaagatatgcacgttttaatgaaaaacgtcagcaaattgatgcggaaattaagcgtttatcagatattcgtattaaaccaaacgaacatacgcaagcgattattgaacaacatggtggttctcgcttaaaagatggtattttagctatcgatttattacgcagacctgaaatgacttacgatataattttagaacttttagaagaagaacatcaattgaatgcagatgttgaagaacaagtagaaatacaaacaaaatatgaaggttatatcaataaatcactacaacaagttgagaaagttaagcgtatggaagagaagaaaattccagaagacttagattatagtaagattgatagtttggcgactgaagcgcgagaaaaattatcagaagtaaaacctttaaatattgcacaagcttctagaatatcaggggtaaatccagcagacatatctatattattgatttacttagaacaaggtaaactccaaagggtgagtgac |
140. | MVQEYDVIVIGAGHAGVEAGLASARRGAKTIMLTINLDNIAFMPCNPSVGGPAKGIVVREIDALGGQMAKTIDKTHIQMRMLNTGKGPAVRALRAQADKVLYQQEMKRVIEDEENLHIMQGMVDELIIEDNEVKGVRTNIGTEYLSKAVIITTGTFLRGEIILGNMKYSSGPNHQLPSITLSDNLRELGFDIVRFKTGTPPRVNSKTIDYSKTEIQPGDDVGRAFSFETTEYILDQLPCWLTYTNAETHKVIDDNLHLSAMYSGMIKGTGPRYCPSIEDKFVRFNDKPRHQLFLEPEGRNTNEVYVQGLSTSLPEHVQRQMLETIPGLEKADMMRAGYAIEYDAIVPTQLWPTLETKMIKNLYTAGQINGTSGYEEAAGQGLMAGINAAGKVLNTGEKLLSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTDMGYELGMISEERYARFNEKRQQIDAEIKRLSDIRIKPNEHTQAIIEQRGGSRLKDGILAIDLLRRPEMTYDIILELLEEEHQLNADVEEQVEIQTKYEGYINKSLQQVEKVKRMEEKKIPEDLDYSKIDSLATEAREKLSEVKPLNIAQASRISGVNPADISILLIYLEQGKLQRVSD |
141. | LMINEREVFILIYLDNAAXTKAFEEVLDTYLKVNQSMYYNPNSPHKAGLQANQLLQQAKTQINAMINSKTNYDVVFTSGATESNNLALKGIAYRKFDTAKEIITSVLEHPSVLEVVRYLEAHEGFKVKYVDVKKDGSINLEHFKELMSDKVGLVTCMYVNNVTGQIQPIPQMAKVIKNYPKAHFHVDAVQAFGKISMDLNNIDSISLSGHKFNGLKGQGVLLVNHIQNVEPTVHGGGQEYGVRSGTVNLPNDIAMVKAMKIANENFEAINAFVTELNNDVRQFLNKYHGVYINSSTSGSPFVLNISFPGVKGEVLVNAFSKYDIMISTTSACSSKRNKLNEVLAAMGLSDKSIEGSIRLSFGATTTKEDIARFKEIFIIIYEEIKELLK |
142. | MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAAEETGGTNTEAQPKTEAVASPTTTSEKAPETKPVANAVSVSNKEVEAPTSETKEAKEVKEVKAPKETKEVKPAAKATNNTYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKKDGTQQFYHYASSVKPARVIFTDSKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSSTHFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQDKLPEKLKAEYKKKLEDTKKALDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPYVEGKTLYDAIVKVHVKTIDYDGQYHVRIVDREAFTKANTDKSNKKEQQDNSAKKEATPATPSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKGVTLATKPTKGEVESSSTTPTKVVSTTQNVAKPTTGSSKTTKDVVQTSAGSSEAKDSAPLQKANIKHTNDGHTQSQNNKNTQENKAKSLPQTGEESNKDMILPLMALLALSSIVAFVLPRKRKN |
143. | atgagctggtttgataaattattcggcgaagataatgattcaaatgatgacttgattcatagaaagaaaaaaagacgtcaagaatcacaaaatatagataacgatcatgactcattactgcctcaaaataatgatatttatagtcgtccgaggggaaaattccgttttcctatgagcgtagcttatgaaaatgaaaatgttgaacaatctgcagatactatttcagatgaaaaagaacaataccatcgagactatcgcaaacaaagccacgattctcgttcacaaaaacgacatcgccgtagaagaaatcaaacaactgaagaacaaaattatagtgaacaacgtgggaattctaaaatatcacagcaaagtataaaatataaagatcattcacattaccatacgaataagccaggtacatatgtttctgcaattaatggtattgagaaggaaacgcacaagccaaaaacacataatatgtattctaataatacaaatcatcgtgctaaagattcaactccagattatcacaaagaaagtttcaagacttcagaggtaccgtcagctatttttggcacaatgaaacctaaaaagttagaaaatggtcgtatccctgtaagtaaaccttcagaaaaagttgagtcagataaacaaaaatatgataaatatgtagctaagacgcaaacgtctcaaaataaacaattagaacaagaaaaacaaaatgatagtgttgtcaaacaaggaactgcatctaaatcatctgatgaaaatgtatcatcaacaacaaaatcaatgcctaattattcaaaagttgataatactatcaaaattgaaaatatttatgcttcacaaattgttgaagaaattagacgtgaacgagaacgtaaagtgcttcaaaagcgtcgatttaaaaaagcgttgcaacaaaagcgtgaagaacataaaaacgaagagcaagatgcaatacaacgtgcaattgatgaaatgtatgctaaacaagcggaacgctatgttggtgatagttcattaaatgatgatagtgacttaacagataatagtacagatgctagtcagcttcatacaaatggcatagagaatgaaactgtatcaaatgatgaaaataaacaagcgtcaatacaaaatgaagacactaatgacactcatgtagatgaaagtccatacaattatgaggaagttagtttgaatcaagtatcgacaacaaaacaattgtcagatgatgaagttacggtttcgaatgtaacgtctcaacatcaatcagcactacaacataacgttgaagtaaatgataaagatgaactaaaaaatcaatccagattaattgctgattcagaagaagatggagcaacgaataaagaagaatattcaggaagtcaaatcgatgatgcagaattttatgaattaaatgatacagaagtagatgaggatactacttcaaatatcgaagataataccaatagaaacgcgtctgaaatgcatgtagacgctcctaaaacgcaagagtacgcagtaactgaatctcaagtaaataatatcgataaaacggttgataatgaaattgaattagcaccgcgtcataaaaaagatgaccaaacaaacttaagtgtcaactcattgaaaacgaatgatgtgaatgataatcatgttgtggaagattcaagcatgaatgaaatagaaaagaataacgcagaaattacagaaaatgtgcaaaacgaagcagctgaaagtgaacaaaatgtcgaagagaaaactattgaaaacgtaaatccaaagaaacagactgaaaaggtttcaactttaagtaaaagaccatttaatgttgtcatgacgccatctgataaaaagcgtatgatggatcgtaaaaagcattcaaaagtcaatgtgcctgaattaaagcctgtacaaagtaagcaagctgtgagtgaaagaatgcctgcgagtcaagccacaccatcatcaagatctgattcacaagagtcaaatacaaatgcatataaaacaaataatatgacatcaaacaatgttgagaacaatcaacttattggtcatgcagaaacagaaaatgattatcaaaatgcacaacaatattcagagcagaaaccttctgttgattcaactcaaacggaaatatttgaagaaagtcaagatgataatcaattggaaaatgagcaagttgatcaatcaacttcgtcttcagtttcagaagtaagcgacataactgaagaaagcgaagaaacaacacatccaaacaatactagtggacaacaagataatgatgatcaacaaaaagatttacagtcatcattttcaaataaaaatgaagatacagctaatgaaaatagacctcggacgaaccaacaagatgttgcaacaaatcaagctgtacaaacatctaagccgatgattcgtaaaggcccaaatattaaattgccaagtgtttcattactagaagaaccacaagttattgagtcggacgaggactggattacagataaaaagaaagaactgaatgacgcattattttactttaatgtacctgcagaagtacaagatgtaactgaaggtccaagtgttacaagatttgaattatcagttgaaaaaggtgttaaagtttcaagaattacggcattacaagatgacattaaaatggcattggcagcgaaagatattcgtatagaagcgcctattccaggaactagtcgtgttggtattgaagttccgaaccaaaatccaacgacagtcaacttacgttctattattgaatctccaagttttaaaaatgctgaatctaaattaacagttgcgatggggtatagaattaataatgaaccattacttatggatattgctaaaacgccacacgcactaattgcaggtgcaactggatcagggaaatcagtttgtatcaatagtattttgatgtctttactatataaaaatcatcctgaggaattaagattattacttatcgatccaaaaatggttgaattagctccttataatggtttgccacatttagttgcaccggtaattacagatgtcaaagcagctacacagagtttaaaatgggccgtagaagaaatggaacgacgttataagttatttgcacattaccatgtacgtaatataacagcatttaacaaaaaagcaccatatgatgaaagaatgccaaaaattgtcattgtaattgatgagttggctgatttaatgatgatggctccgcaagaagttgaacagtctattgctagaattgctcaaaaagcgagagcatgtggtattcatatgttagtagctacgcaaagaccatctgtcaatgtaattacaggtttaattaaagccaacataccaacaagaattgcatttatggtatcatcaagtgtagattcgagaacgatattagacagtggtggagcagaacgcttgttaggatatggcgatatgttatatcttggtagcggtatgaataaaccgattagagttcaaggtacatttgtttctgatgacgaaattgatgatgttgttgattttatcaaacaacaaagagaaccggactatctatttgaagaaaaagaattgttgaaaaaaacacaaacacaatcacaagatgaattatttgatgatgtttgtgcatttatggttaatgaaggacatatttcaacatcattaatccaaagacatttccaaattggctataatagagcagcaagaattatcgatcaattagagcaactcggttatgtttcgagtgctaatggttcaaaaccaagggatgtttatgttacggaagcagatttaaataaagaa |
144. | atgcctaaacgtaatgatatcaaaacaattttagtaatagggtctgggccaattatcataggtcaagcagctgaatttgattatgctggaacacaagcatgtctagctttaaaagaagagggatatcgagttattcttgtaaattcaaatccagcgacaatcatgactgataaggaaattgcggataaagtatatatcgaaccgttaactcatgattttatagcgcgaattatacgtaaagagcaacctgacgctttacttccaactttaggtggtcaaacaggtttaaacatggcgattcaactacacgaaagtggtgtgcttcaagataataacgtccaattattaggaactgagctaacatcaattcaacaagcagaagaccgtgaaatgtttagaacattaatgaatgatttaaacgttcctgtaccagagagtgacattgtaaatacagtagagcaagcctttaaattcaaagagcaagtgggatacccgctaattgttagaccggcatttacgatgggtggtaccggaggcggtatttgtcataatgatgaagaattacatgaaatcgtctcaaatggtcttcattatagtccagcaacgcaatgtttattagaaaaatctatcgcaggttttaaagaaatcgaatacgaagtaatgcgtgataaaaacgataatgccatcgttgtatgtaacatggaaaatattgatccagttggtattcatacaggcgattcaattgttgtggctcctagtcaaacattatcagatgttgagtatcaaatgttacgtgatgtttcattaaaagttattcgagctttaggtatcgaaggtggttgtaatgttcaattagcattagatccccattcattcgattattatattatagaagtaaatccgcgtgtatcacgttcatcagcgttagcttcaaaagcaacaggatatcctattgcaaaattagctgctaaaatcgcggttggtctaacattagatgaaatgttaaatccaattacaggaacatcttatgcagcgtttgaaccaactttagactatgtgatttcaaaaataccaagatttccttttgataaatttgaaaaaggagaacgagagcttggcacacaaatgaaagcaacaggtgaagttatggccattggtcgaacttacgaagaatcattgttaaaagcaattcgatcacttgagtatggtgtgcatcacttaggattaccaaatggtgaaagcttcgatcttgattatattaaagaacgtatttcacaccaagatgatgaacgattatttttcatcggcgaagcaattagaagaggcacaacattagaagaaattcataatatgactcagattgattacttcttcttacacaagttccaaaacattattgatattgagcatcaattaaaagagcatcaaggtgatttagaatatcttaaatatgcaaaagattatggatttagtgataaaacaatagcgcatcgctttaatatgacggaagaagaagtatatcaattgcgtatggaaaatgatattaaacctgtttacaagatggttgatacttgcgcagctgaatttgaatcttcaacaccatattattatggtacatacgaaactgaaaatgaatccatagttactgacaaagaaaaaatcttagtattaggctctggaccaattcgaatcggccaaggtgtagaatttgactatgcgacagttcatgccgtttgggcaattcaaaaagcagggtacgaagcgataattgtgaataacaatccagaaacagtttcaacagacttctcaatttctgacaaattatactttgaacctttaactgaagaagatgtgatgaatatcattaatttagaaaaacctaaaggtgtcgttgtacaatttggaggacaaacagcgattaatttagcagacaaattggctaaacatggtgttaaaatacttggtacttcactagaaaatctaaatcgtgctgaagatagaaaagaatttgaagcactattaagaaaaattaacgtgccacagccacaagggaaaacagctacatcacctgaggaagcattagcgaatgctgcagaaatcggatatccggttgtagtaagaccttcttatgtattaggtggtcgcgcaatggaaattgtagacaatgacaaagagttagaaaactatatgacccaggctgtaaaagcgagtccggaacatccggtactagtcgatagatatttaactggtaaagaaattgaagttgatgcgatttgtgatggagaaacggtcattattccaggaatcatggaacatattgaacgtgctggtgtgcatagtggtgactcaatcgctgtatatccaccacaaactttgacagaagacgagttagcaacacttgaggactatactataaaattagctaaaggtttaaacatcattggcttaatcaacattcaattcgttatagctcacgatggtgtgtatgttttagaagtaaatccacgttctagtagaacggtaccattcttaagtaaaattactgatattccaatggcacaattagctatgcgagcaatcattggggaaaaactaacagatatgggttatcaagaaggggttcaaccatatgctgagggtgtctttgtgaaagcaccagtatttagttttaataaattgaaaaatgttgatattactttaggacctgaaatgaagtcaacaggtgaagtgatggggaaagatactacattagaaaaggcgttattcaaagggttaacaggtagtggcgttgaagttaaagatcacggtacagtattaatgaccgtcagtgacaaagataaagaggaagttgttaaattggcacaacgcttaaatgaagttggctataaaattttagcaacgtctggaacagctaataaattagctgagtatgacatacctgcagaagtagtaggcaaaattggtggcgaaaatgatttattaacacgtattcaaaatggtgatgttcaaatcgttataaatacaatgactaaaggtaaagaagtagaaagggatggcttccaaattagacgtactacagttgaaaatggtattccatgtttgacatctttagatacagctaatgccttaacgaatgtaattgaaagtatgacatttacaatgcgtcaaatg |
145. | atgattaacagggataataaaaaggcaataacaaaaaagggtatgatttcaaatcgcttaaacaaattttcgattagaaagtatactgtaggaactgcatcgattttagtaggtacgacattgatttttggtctagggaaccaagaagctaaagctgctgaaaacactagtacagaaaatgcaaaacaagatgatgcaacgactagtgataataaagaagtagtgtcggaaactgaaaataattcgacaacagaaaataattcaacaaatccaattaagaaagaaacaaatactgattcacaaccagaagctaaaaaagaatcaacttcatcaagtactcaaaaacagcaaaataacgttacagctacaactgaaactaagcctcaaaacattgaaaaagaaaatgttaaaccttcaactgatgaaactgcgacagaagatacatctgttattttagaagagaagaaagcaccaaataatacaaataacgatgtaactacaaaaccatctacaagtgaaccatctacaagtgaaattcaaacaaaaccaactacacctcaagaatctacaaatattgaaaattcacaaccgcaaccaacgccttcaaaagtagacaatcaagttacagatgcaactaatccaaaagaaccagtaaatgtgtcaaaagaagaacttaaaaaaatcctgagaaattaaaagaattggttaagaaatgatagcaatacagatcattcaactaaaccagttgctacagctccaacaagtgttgcaccaaaacgtgtaaacgcaaaaatgcgctttgcagttgcacaaccagcagcagttgcttcaaacaatgtaaatgatttaattaaagtgacgaagcaaacaatcaaagttggcgatggtaaagataatgtggcagcagcgcatgacggtaaagatattgaatatgatacagagtttacaattgacaataaagtcaaaaaaggcgatacaatgacgattaattatgataagaatgtaattccttcggatttaacagataaaaatgatcctatcgatattactgatccatcaggagaggtcattgctaaaggaacatttgataaagcaactaagcaaatcacatatacatttacagactatgtagataaatatgaagatataaaatcacgcttaactctatattcgtatattgataaaaaaacagttccaaatgagacaagtttgaatttaacatttgctacagcaggtaaagaaacaagccaaaatgtcactgttgattatcaagatccaatggtccatggtgattcaaacattcaatctatctttacaaaattagatgaagataagcaaactattgaacaacaaatttatgttaacccattgaaaaaatcagcaaccaacactaaagttgatatagctggtagtcaagtagatgattatggaaatattaaactaggaaatggtagcaccattattgaccaaaatacagaaataaaggtttataaagttaactctgatcaacaattgcctcaaagtaatagaatctatgattttagtcaatacgaagatgtaacaagtcaatttgataataaaaaatcatttagtaataatgtagcaacattggattttggtgatattaattcagcctatattatcaaagttgttagtaaatatacacctacatcagatggcgaactagatattgcccaaggtactagtatgagaacaactgataaatatggttattataattatgcaggatattcaaacttcatcgtaacttctaatgacactggcggtggcgacggtactgttaaacctgaagaaaagttatacaaaattggtgactatgtatgggaagacgttgataaagacggtgttcaaggtacagattcaaaagaaaaaccaatggcaaacgttttagttacattaacttacccggacggtactacaaaatcagtaagaacagatgctaatggtcattatgaattcggtggtttgaaagacggagaaacttatacagttaaattcgaaacgccaactggatatcttccaacaaaagtaaatggaacaactgatggtgaaaaagactcaaatggtagttcggttactgttaaaattaatggtaaagatgatatgtctttagatactggtttttacaaagaacctaaatacaacttaggtgactatgtatgggaagatactaataaagatggtatccaagatgcaaatgagccaggaatcaaagatgttaaggttacattaaaagatagtactggaaaagttattggtacaactactactgatgcctcgggtaaatataaatttacagatttagataatggtaactatacagtagaatttgaaacaccagcaggttacacgccaacggttaaaaatactacagctgatgataaagattctaatggtttaacaacaacaggtgtcattaaagatgcagataatatgacattagacaggggtttctataaaacaccaaaatacagtttaggtgattatgtttggtacgacagtaataaagacggcaaacaagattcaactgaaaaaggtatcaaagatgtgacagttacattgcaaaacgaaaaaggcgaagtaattggaacaactaaaacagatgaaaatggtaaatatcgtttcgataatttagatagcggtaaatacaaagttatttttgaaaagcctgctggcttaacacaaacagttacaaatacaactgaagatgataaagatgcagatggtggcgaagttgacgtaacaattacggatcatgatgatttcacacttgataacggatacttcgaagaagatacatcagacagcgattcagactcagatagtgactcagacagcgactcagactcagacagcgactcagactcagacagtgattcagattcagacagcgactcagattcagatagcgactcagattcggacagcgattcagactcagatagcgactcagattcagatagcgattcagactcagacagcgactcagattcagatagcgattcggactcagacagcgattcagactcagatagcgactcagactcagacagcgactcagattcagatagcgattcggactcagatagcgactcagattcagacagcgattcagactcagatagcgactcagattcagacagcgattcagactcagatagcgactcagactcagacagtgattcagattcagacagcgactcagactcagatagcgactcagattcggacagcgactcagactcagatagcgactcagactcagacagtgattcagacagcgattcagactcggatgcaggaaaacatacacctgttaaaccaatgagtactactaaagaccatcacaataaagcaaaagcattaccagaaacaggtagtgaaaataacggctcaaataacgcaacgttatttggtggattatttgcagcattaggttcattattgttattcggtcgtcgcaaaaaacaaaacaaa |
146. | atgactcatttattagagacatttgagatgtcaatagatcaccaggaagatggtttagttgttatttctatgcctgttactgataaagtaaaacaaccatttggatatttacatggtggggcttcgattgctttaggtgaaacagcatgttcattaggatctgctaatttaattgatacaaccaaatttattccattaggtttagagatgaatgctaaccatattcattctgctaaagatggtcgtgttactgcgacagctgaaattattcatcgaggtaagtcgacacatgtatgggatataaaaattaagaatgacaaagaacaattaattacagttatgcgtggtacagttgctattaaacctttaaaa |
147. | atggagcatacaactatgaaaataacaacgattgctaaaacaagtttagcactaggccttttaacaacaggtgtaatcacaacgacaacgcaagcagcaaacgcgacaacaccatcttccactaaagtggaagcaccacaatcaacaccgccctcaactaaaatagaagcaccgcaatcaaaaccaaacgcgacaacaccgccctcaactaaagtagaagcaccgcaacaaacagcaaatgcgacaacaccgccttcaactaaagtgacaacacctccatcaacaaacacgccacaaccaatgcaatctactaaatcagacacaccacaatcgccaaccacaaaacaagtaccaacagaaataaatcctaaatttaaagatttaagagcgtattatacgaaaccaagtttagaatttaaaaatgagattggtattattttaaaaaaatggacgacaataagatttatgaatgttgtcccagattatttcatatataaaattgctttagttggtaaagatgataaaaaatatggtgaaggagtacataggaatgtcgatgtatttgtcgttttagaagaaaataattacaatctggaaaaatattctgtcggtggtatcacaaagagtaatagtaaaaaagttgatcacaaagcaggagtaagaattactaaggaagataataaaggtacaatctctcatgatgtttcagaattcaagattactaaagaacagatttccttgaaagaacttgattttaaattgagaaaacaacttattgaaaaaaataatctgtacggtaacgttggttcaggtaaaattgttattaaaatgaaaaacggtggaaagtacacgtttgaattgcacaaaaaattacaagaaaatcgcatggcagatgtcattaatagtgaacaaattaaaaacatcgaagtgaatttgaaa |
148. | atgaaaaagcaaataatttcgctaggcgcattagcagttgcatctagcttatttacatgggataacaaagcagatgcgatagtaacaaaggattatagtgggaaatcacaagttaatgctgggagtaaaaatgggacattaatagatagcagatatttaaattcagctctatattatttggaagactatataatttatgctataggattaactaataaatatgaatatggagataatatttataaagaagctaaagataggttgttggaaaaggtattaagggaagatcaatatcttttggagagaaagaaatctcaatatgaagattataaacaatggtatgcaaattataaaaaagaaaatcctcgtacagatttaaaaatggctaattttcataaatataatttagaagaactttcgatgaaagaatacaatgaactacaggatgcattaaagagagcactggatgattttcacagagaagttaaagatattaaggataagaattcagacttgaaaacttttaatgcagcagaagaagataaagcaactaaggaagtatacgatctcgtatctgaaattgatacattagttgtatcatattatggtgataaggattatggggagcacgcgaaagagttacgagcaaaactggacttaatccttggagatacagacaatccacataaaattacaaatgaacgtattaaaaaagaaatgattgatgacttaaattcaattattgatgatttctttatggaaactaaacaaaatagaccgaaatctataacgaaatataatcctacaacacataactataaaacaaatagtgataataaacctaattttgataaattagttgaagaaacgaaaaaagcagttaaagaagcagatgattcttggaaaaagaaaactgtcaaaaataacggagaaactgaaacaaaatcgccagtagtaaaagaagagaagaaagttgaagaacctcaagcacctaaagttgataaccaacaagaggttaaaactacggctggtaaagctgaagaaacaacacaaccagttgcacaaccattagttaaaattccacagggcacaattacaggtgaaattgtaaaaggtccggaatatccaacgatggaaaataaaacggtacaaggtgaaatcgttcaaggtcccgattttctaacaatggaacaaagcggcccatcattaagcaataattatacaaacccaccgttaacgaaccctattttagaaggtcttgaaggtagctcatctaaacttgaaataaaaccacaaggtactgaatcaacgttaaaaggtatcaaggagaatcaaggtgatattgaagttaaacctcaagcaactgaaacaacagaagcttctcaatatggtccgagaccgcaatttaacaaaacacctaaatatgttaaatatagagatgctggtacaggtatccgtgaatacaacgatggaacatttggatatgaagcgagaccaagattcaataagccatcagaaacaaatgcatataacgtaacaacacatgcaaatggtcaagtatcatacggagctcgtccgacatacaagaagccaagcgaaacgaatgcatacaatgtaacaacacatgcaaacggccaagtatcatacggagctcgtccgacacaaaacaagccaagcaaaacaaacgcatataacgtaacaacacatggaaacggccaagtatcatatggcgctcgcccaacacaaaacaagccaagcaaaacaaatgcatacaacgtaacaacacatgcaaacggtcaagtgtcatacggagctcgcccgacatacaagaagccaagtaaaacaaatgcatacaatgtaacaacacatgcagatggtactgcgacatatgggcctagagtaacaaaa |
149. | atgaaaaaattagcaacagtaggttctttaattgtaacaagcactttagtattctcaagtatgccttttcaaaatgcgcatgccgacacaacttcaatgaatgtgtcgaataaacaaagccaaaatgtacaaaatcatcgtccttatggcggagtagtaccacaaggaatgacgcaagcacaatatactgaattagagaaagctttaccccaattaagcgctggcagtaatatgcaagactataatatgaaattgtatgatgcgacgcaaaatattgctgacaaatacaatgtgataattacaactaatgtaggggtatttaaaccacatgctgttagagatatgaatggccatgcgttacctttaacaaaagatggcaatttttatcaaacgaatgtagatgcaaatggtgttaatcatggtggtagtgaaatggtgcaaaataaaacaggtcatatgagtcaacaaggccatatgaatcagaacacacacatgaaccaacagccacacatgcaacaaggtcatatgcaatcatcaaaccatcaaatgatgagtccaaaagcaaatatgcattcatcaaatcatcaaatgaaccaaagtaacaaaaaagttttaccagctgctggtgaaagtatgacatcaagtattcttactgcaagtattgccgcactactattagtatctgggttattcttagcatttagacgacgttcaacaaataaa |
150. | gtgcttaggagtgatttttatatgtcttattccattgttagagtttcaaaagttaaatctggaacaaatacaacgggcatacaaaaacatgttcaaagagaaaataataattatgaaaatgaagatatagaccatagtaaaacttacttaaattatgatttggtaaatgctaataaacagaattttaataacttgattgatgaaaaaatcgaacagaattatacaggcaaaagaaaaattagaacagacgcgattaaacacattgatggtttaattacatcagacaatgatttctttgataatcaaacgccagaagatacaaagcagttttttgaatatgctaaagagtttttagaacaagaatacggtaaagataatttattatatgcaacagttcacatggacgaaaaaacaccacatatgcattatggcgttgttccaataactgatgatggtcgtttaagtgctaaagaagttgtaggtaataaaaaagctttaacagcgtttcaagatagatttaatgagcatgttaaacaacgaggatatgatttagaacgtgggcaatcaagacaagtaacaaatgctaaacatgagcaaataagtcagtataaacaaaaaacagaatatcataagcaagaatatgaacgtgagagccaaaaaacagaccatataaagcaaaagaacgataaattaatgcaagagtaccaaaaatcgttaaatacgcttaaaaagcctataaatgttccgtatgagcaagaaactgaaaaagtaggtggtttatttagcaaagaaatacaagaaactggaaatgttgtaataagccaaaaagatttcaatgaatttcagaaacagataaaagctgctcaagatatttcggaagattacgagtatataaagtctggtagagccttagatgataaagataaggaaatacgagagaaagatgatttattaaataaagcagttgagcgtattgaaaacgcagacgataattttaaccaactttacgaaaatgcaaagccacttaaagagaatatagaaatagcgttaaagcttttaaaaatcttactaaaagagttagaacgagttttaggaagaaatacctttgcggaaagagttaataagttaacagaagatgaacctatggca |
151. | MSWFDKLFGEDNDSNDDLIHRKKKRRQESQNIDNDHDSLLPQNNDIYSRPRGKFRFPMSVAYENENVEQSADTISDEKEQYHRDYRKQSHDSRSQKRHRRRRNQTTEEQNYSEQRGNSKISQQSIKYKDHSHYHTNKPGTYVSAINGIEKETHKPKTHNMYSNNTNHRAKDSTPDYHKESFKTSEVPSAIFGTMKPKKLENGRIPVSKPSEKVESDKQKYDKYVAKTQTSQNKQLEQEKQNDSVVKQGTASKSSDENVSSTTKSMPNYSKVDNTIKIENIYASQIVEEIRRERERKVLQKRRFKKALQQKREEHKNEEQDAIQRAIDEMYAKQAERYVGDSSLNDDSDLTDNSTDASQLHTNGIENETVSNDENKQASIQNEDTNDTHVDESPYNYEEVSLNQVSTTKQLSDDEVTVSNVTSQHQSALQHNVEVNDKDELKNQSRLIADSEEDGATNKEEYSGSQIDDAEFYELNDTEVDEDTTSNIEDNTNRNASEMHVDAPKTQEYAVTESQVNNIDKTVDNEIELAPRHKKDDQTNLSVNSLKTNDVNDNHVVEDSSMNEIEKNNAEITENVQNEAAESEQNVEEKTIENVNPKKQTEKVSTLSKRPFNVVMTPSDKKRMMDRKKHSKVNVPELKPVQSKQAVSERMPASQATPSSRSDSQESNTNAYKTNNMTSNNVENNQLIGHAETENDYQNAQQYSEQKPSVDSTQTEIFEESQDDNQLENEQVDQSTSSSVSEVSDITEESEETTHPNNTSGQQDNDDQQKDLQSSFSNKNEDTANENRPRTNQQDVATNQAVQTSKPMIRKGPNIKLPSVSLLEEPQVIESDEDWITDKKKELNDALFYFNVPAEVQDVTEGPSVTRFELSVEKGVKVSRITALQDDIKMALAAKDIRIEAPIPGTSRVGIEVPNQNPTTVNLRSIIESPSFKNAESKLTVAMGYRINNEPLLMDIAKTPHALIAGATGSGKSVCINSILMSLLYKNHPEELRLLLIDPKMVELAPYNGLPHLVAPVITDVKAATQSLKWAVEEMERRYKLFAHYHVRNITAFNKKAPYDERMPKIVIVIDELADLMMMAPQEVEQSIARIAQKARACGIHMLVATQRPSVNVITGLIKANIPTRIAFMVSSSVDSRTILDSGGAERLLGYGDMLYLGSGMNKPIRVQGTFVSDDEIDDVVDFIKQQREPDYLFEEKELLKKTQTQSQDELFDDVCAFMVNEGHISTSLIQRHFQIGYNRAARIIDQLEQLGYVSSANGSKPRDVYVTEADLNKE |
152. | MPKRNDIKTILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYRVILVNSNPATINTDKEIADKVYIEPLTHDFIARIIRKEQPDALLPTLGGQTGLNMAIQLHESGVLQDNNVQLLGTELTSIQQAEDRENFRTLNNDLNVPVPESDIVNTVEQAFKFKEQVGYPLIVRPAFTMGGTGGGICHNDEELHBTVSNGLHYSPATQCLLRKSIAGFKEIEYEVMRDKNDNAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDVEYQMLRDVSLKVIRALGIEGGCMVQLALDPHSFDYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDENLNPITGTSYAAFEPTLDYVISKIPRFPFDKFEKGERELGTQMKATGEVMAIGRTYSESLLKAIRSLEYGVHHIGLPNGESFDLDYIKERISHQDDERLFFIGEAIRRGTTLEEIHNMTQIDYFFLHKFQNIIDIEHQLKEHQGDLEYLKYAKDYGFSDKTIAHRFNMTEEEVYQLRMENDIKPVYKMVDTCAAEFESSTPYYYGTYETENESIVTDKEKILVLGSGPIRIGQGVEFDYATVHAVWAIQKAGYEAIIVNNNPETVSTDFSISDKLYFEPLTEEDVMNIINLEKPKGVVVQFGGQTAINLADKLAKHGVKILGTSLENLNRAEDRKRFEALLRKINVPQPQGKTATSPEEALANAAEIGYPVVVRPSYVLGGRAMEIVDNDKELENYMTQAVKASPEHPVLVDRYLTGKEIEVDAICDGETVIIPGIMERIERAGVHSGDSIAVYPPQTLTEDELATLEDYTIKLAKGLNIIGLINIQFVIAHDGVYVLEVNPRSSRTVPFLSKITDIPMAQLAMRAIIGERLTDMGYQEGVQPYAEGVFVKAPVFSFNKLKNVDITLGPEMKSTGEVMGKDTTLEKALFKGLTGSGVEVKDHGTVLMRVSDKDKEEVVKLAQRLNEVGYKILATSGTANKLAEYDIPAEVVGKIGGENDLLTRIQNGDVQIVINTMTKGKEVERDGFQIRRTTVENGIPCLTSLDTANALTNVIESMTFTMRQM |
153. | MINRDNKKAITKKGMISNRLNKFSIRKYTVGTASILVGTTLIFGLGNQEAKAAENTSTENAKQDDATTSDNKEVVSETENNSTTENNSTNPIKKETNTDSQPEAKKESTSSSTQKQQNNVTATTETKPQNIEKENVKPSTDKTATEDTSVILEEKKAPNNTNNDVTTKPSTSEPSTSEIQTKPTTPQESTNIENSQPQPTPSKVKNQVTDATNPKEPVNVSKEELKKNPEKLKELVRNDSNTDHSTKPVATAPTSVAPKRVNAKMRFAVAQPAAVASNNVNDLIKVTKQTLKVGDGKDNVAAAHDGKDIEYDTEFTIDNKVKKGDTMTINYDKNVIPSDLTDKNDPIDITDPSGEVIAKGTFDKATKQITYTFTDYVDKYEDIKSRLTLYSYIDKKTVPNETSLNLTFATAGKETSQNVTVDYQDPMVHGDSNIQSIFTKLDEDKQTIEQQIYVNPLKKSATNTKVDIAGSQVDDYGNIKLGNGSTIIDQNTEIKVYKVNSDQQLPQSNRIYDFSQYEDVTSQFDNKKSFSNNVATLDFGDINSAYIIKVVSKYTPTSDGELDLAQGTSMRTTDKYGYYNYAGYSNFIVTSNDTGGGDGTVKPEEKLYKIGDYVWEDVDKDGVQGTDSKEKPMANVLVTLTYPDGTTKSVRTDANGHYEFGGLKDGETYTVKFETPTGYLPTKVNGTTDGEKDSNGSSVTVKINGKDDMSLDTGFYKEPKYNLGDYVWEDTNKDGIQDANEPGIKDVKVTLKDSTGKVIGTTTTDASGKYGKYKTDLDGYTVEFETPAGYTPTVKNTTADDKDSNGLTTTGVIKDADNMTLDRGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDVTVTLQNEKGEVIGTTKTDENGKYRFDNLDSGKYKVIFEKPAGLTQTVTNTTEDDKDADGGEVDVTITDHDDFTLDNGYFEEDTSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGSENNGSNNATLFGGLFAALGSLLLFGRRKKQNK |
154. | MTHLLETFEMSIDHQEDGLVVISMPVTDKVKQPFGYLHGGASIAIGETACSLGSANLIDTTKFIPLGLEMNANHIHSAKDGRVTATAEIIHRGKSTHVWDIKIKNDKEQLITVMRGTVAIKPLK |
155. | MEHTTMKITTIAKTSLALGLLTTGVITTTTQAANATTPSSTKVEAPQSTPPSTKIEAPQSKPNATTPPSTKVEAPQQTANATTPPSTKVTTPPSTNTPQPMQSTKSDTPQSPTTKQVPTEINPKFKDLRAYYTKPSLEFKNEIGIILKKWTTIRFMNVVPDYFIYKIALVGKDDKKYGEGVHRNVDVFVVLEENNYNLEKYSVGGITKSNSKKVDHKAGVRITKEDNKGTISHDVSEFKITKEQISLKELDFKLRKQLIEKNNLYGNVGSGKINIKMKNGGKYTFELHKKLQENRMADVINSEQIKNIEVNLK |
156. | MKKQIISLGALAVASSLFTWDNKADAIVTKDYSGKSQVNAGSKNGTLIDSRYLNSALYYLEDYIIYAIGLTNKYEYGDNIYKEAKDRLLEKVLREDWYLLERKKSQYEDYKQWYANYKKENPRTDLKMANFHKYNLEELSMKEYNELQDALKRALDDFHREVKDIKDKNSDLKTFNAAEEDKATKEVYDLVSEIDTLVVSYYGDKGYGEHAKELRAKLDLILGDTDNPHKITNERIKKEMIDDLNSIIDDFFMETKQNRPKSITKYNPTTHNYKTNSDNKPNFDKLVEETKKAVKEADDSWKKKTVKKYGETETKSPVVKEEKKVEEPQAPKVDNQQEVKTTAGKAEETTQPVAQPLVKIPQGTITGEIVKGPEYPTMENKTVQGEIVQGPDFLTMEQSGPSLSNNYTNPPLTNPILEGLEGSSSKLEIKPQGTESTLKGTQGESSDIEVKPQATETTEASQYGPRPQFNKTPKYVKYRDAGTGIREYNDGTFGYEARPRFNKPSEINAYNVTTHANGQVSYGARPTYKKPSETNAYNVTTHANGQVSYGARPTQNKPSKTNAYNVTTHGNGQVSYGARPTQNKPSKTNAYNVTTHANGQVSYGARPTYKKPSKTNAYNVTTHADGTATYGPRVTK |
157. | MKKLATVGSLIVTSTLVFSSMPFQNAHADTTSMNVSNKQSQNVQNHRPYGGVVPQGMTQAQYTELEKALPQLSAGSNMQDYNMKLYDATQNIADKYNVIITTNVGVFKPHAVRDMNGHALPLTKDGNFYQTNVDANGVNHGGSEMVQNKTGHMSQQGHMNQNTHMNQQPHMQQGHMQSSNHQMMSPKANMHSSNHQMNQSNKKVLPAAGESMTSSILTASIAALLLVSGLFLAFRRRSTNK |
158. | VLRSDFYMSYSIVRVSKVKSGTNTTGIQKHVQRENNNYENEDIDHSKTYLNYDLVNANKQNFNNLIDEKIEQNYTGKRKIRTDAIKHIDGLITSDNDFFDNQTPEDTKQFFEYAKEFLEQEYGKDNLLYATVHMDEKTPHMHYGVVPITDDGRLSAKEVVGNKKALTAFQDRFNEHVKQRGYDLERGQSRQVTNAKHEQISQYKQKTEYHKQEYERESQKTDHIKQKNDKLMQEYQKSLNTLKKPINVPYEQETEKVGGLFSKEIQETGNVVISQKDFNEFQKQIKAAQDISEDYEYIKSGRALDDKDKEIREKDDLLNKAVERIENADDNFNQLYENAKPLKENIEIALKLLKILLKELERVLGRNTFAERVNKLTEDEPMA |
159. | atgatgaaaaagttaaaagcgagtgaaattagacaaaaatatctagatttctttgttgaaaaaggacatatggttgaaccttctgcaccattagtgccaattgatgatgatacattattatggattaattcaggtgtagcaacattaaagaaatattttgatggacgtgaaacacctaaaaagccaagaattgtaaactctcaaaaagctattcgtacaaatgatattgaaaatgttggtttcacagcgcgtcaccatacattctttgaaatgttaggtaacttctcaattggtgattattttaaacaagaagcgattgaatttgcttgggaatttttaacgagtgataaatggatgggtatggagccagataaattgtacgttacgattcatccggaagatatggaagcatacaacatttggcataaagatattgggcttgaagaaagtcgtattattcgcattgaaggtaacttctggGatattggtgaagggccttcaggaccgaacactgagattttctatgatcgcggagaagcatatggacaagacgatccggcagaagaaatgtatccaggtggagaaaatgaacgctatcttgaagtatggaacttagtatttagtgaattcaatcataataaagatcatagttacacaccattacctaataaaaatattgatactggcatggggcttgagcgtatggcctcagtttctcaaaatgtacgtactaactatgaaacagatttatttatgcctataatgaatgaaatcgaaaaagtatcaggtaaacaatatttagtaaacaacgaacaagatgtggcatttaaagtaattgctgaccacattcgtacgattgcatttgcaatttctgatggtgcattacctgccaatgaaggtagagggtatgtattacgtcgattgttacgtcgtgccgttcgttttagtcaaacgttaggaatcaatgagccatttatgtacaaacttgttgatattGttgcagacattatggaaccatattatccaaatgttaaggaaaaagcagatttcattaagcgtgttataaagtctgaagaagaacgattccatgaaacattagaagatggtttagcgattttaaatgaattaattaaaaaagctaaagcgacaacaaatgaaattaatgggaaagatgcatttaaattgtatgatacgtatgggttcccaattgaattaactgaagaaatagcagtgcaagcaggattgaaagttgatatgacaacattcgagtcagaaatgcaacaacaacgtgatcgtgcacgtcaagcacgtcaaaattctcaatcaatgcaagttcaaagtgaagtattgaaaaatattacatctgcaagtacttttgttggttatgatactgcgacagctcaaacaacactaacacacttgatatacaatggtgaagaagtttcacaagttgaagcgggtgaaacagtatacttcatgttaacggaaacaccattttatgcaatcagtggtggacaagttgcggatacaggtattgtttataatgacaattttgaaattgctgttagtgaagtaaccaaagcaccaaatggtcaaaacttgcataaaggagtagtacaatttggccaagtaaatgttggcgctacagtgtctgctgaagtgaaccaaaatgatcgacgtgacattcaaaagaaccatagtgcaacacatttattacatgcagcgttgaaatcagttctgggtgatcatgttaaccaagctggttcactagtagaagcagatcgtttacgttttgatttctctcattttggtccaatgactaatgatgaaattgatcaagttgaacgcttagtaaatgaagaaatttggaaaggtattgacgttaacattcaagaaatggatattgcttcagctaaagaaatgggcgcaatggcattattcggtgaaaaatatggtgatgttgtgcgtgtagtaaatatggcaccattttcaattgaattatgtggtggtattcatgtccgcaatacttctgaaattggcttattcaaaatagtaagtgatcaggtacacaggagctggtgtgcgtcgtattgagcattaacaggtaaagcagctttcttatatttagaagatattcaagagaaatttaatacgatgaaatcacagctgaaagtgaaatctgatgatcaagtagtcgataagttaacacaattacaagatgaagaaaaagcattattaaaacaattagagcaacgtgacaaagaaatcacatcacttaaaatgggtaatattgaagatcaagttgaagaaatcaatggctataaagtattggttactgaagtggatgtaccaaatgcgaaagcaattcgctcgacaatggacgattttaaatctaaactacaagatacaattatcattcttgcagtaatgttgatgataaaagtatcgatggttgcaactgtccctaaatctttaacaaataacgttaaagccggtgatcttatcaaacaaatggcaccaatcgttggtggtaaaggtggcggtcgtccagatatggctcaaggtggcggtacacaacctgaaaatatctcaaaatcattaagctttattaaagattacattaaaaatcta |
160. | MMKKLKASRIRQKYLDFFVEKGHMVEPSAPLVPIDDDTLLWINSGVATLKKYFDGRETPKKPRIVNSQKAIRTNDIENVGFTARHHTFFEMLGNFSIGDYFKQEAIEFAWEFLTSDKWMGMEPDKLYVTIHPEDMEAYNIWHKDIGLEESRIIRIEGNFWDIGEGPSGPNTEIFYDRGEAYGQDDPAEEMYPGGENERYLEVWNLVFSEFNHNKDHSYTPLPNKNIDTGMGLERMASVSQNVRTNYETDLFMPIMNEIIKVSGKQYLVNNEQDVAFKVIADHIRTIAFAISDGALPANEGRGYVLRRLLRRAVRFSQTLGINEPFMYKLVDIVADIMEPYYPNVKEKADFIKRVIKSEEERFHETLEDGLAILNELIKKAKATTNKINGKDAFKLYDTYGFPIELTEEIAVQAGLKVDMTTFESEMQQQRDRARQARQNSQSMQVQSEVLKNITSASTFVGYDTATAQTTLTHLIYNGEEVSQVEAGETVYFMLTETPFYAISGGQVADTGIVYNDNFEIAVSEVTKAPNGQNLHKGVVQFGQVNVGATVSAEVNQNDRRDIQKNHSATHLLHAALKSVLGDHVNQAGSLVEADRLRFDFSHFGPMINDEIDQVERLVNEEIWKGIDVNIQEMDIASAKEMQAMALFGEKYGDVVRVVNMAPFSIELCGGIHVRNTSEIGLFKINSESGTGAGVRRIEALTGKAAFLYLEDIQEKFNTMKSQLKVKSDDQVVDKLTQLQDREKALLKQLEQRDKEITSLKMGNIEDQVEEINGYKVLYTEVDVPNAKAIRSTMDDFKSKLQDTIIILASNVDDKVSMVATVPKSLTNNVKAGDLIKQMAPIVGGKGGGRPDMAQGGGTQPENISKSLSFIKDYIKNL |
161. | atgaatagtgagtttatatatggacgggtaacaaatttaggaggtaagattttgagtttaataaagaaaaagaataaagatattcgcattataccattaggcggtgttggcgaaattgctaaaaatatgtatatcgttgaagtagacgatgaaatgtttatgttagatgctggacttatgtttccagaagacgaaatgctaggtattgatattgttataccagacatttcatacGtacttgaaaataaagataaattgaagggtatattccttacacacggacatgagcacgcgattggtgcagtgagttatgttttagaacaattagatgcaccagtatatggatctaaattgacaatagcgttaattaaagaaaatatgaaagcccgtaatattgataaaaaagttcgctactatacagttaataatgattcaattatgagattcaaaaacgtgaatattagtttctttaatacgacacacagtattcctgatagtttaggtgtttgtattcacacttcatatggtgccattgtgtatacaggtggaatttagtttgaccaaagtttacatggacattatgcaccagatattaaacgtatggcagagattggtgaagaaggcgtatttgtcttaatcagtgattctactgaggcagagaaacctggatataatactccggaaaatgtgattgaacatcatatgtatgatgcttttgcaaaagtgcgaggtcgcttgatagtttcatgttatgcttcgaactttatacgtattcagcaagttttaaatattgctagcaagctaaatcgtaaagtgtcatttttaggaagatcacttgaaagttcatttaatattgctcgtaaaatggggtatttcgacattcctaaagatttgctaattcctataacagaagttgataattatcctaaaaatgaagtgataattatagctactggtatgcaaggagaacctgtagaagccttaagtcaaatggcgcaacataagcataaaattatgaataccgaagaaggcgattctgtatttttagcaattacggcttctgctaatatggaagttatcattgcgaatacattaaatgagcttgtacgtgctggcgcacatattattccaaataacaaaaagattcatgcttcaagtcatggttgcatggaagaattaaaaatgatgattaatattatgaaacctgaatactttattcctgtacaaggtgaatttaaaatgcagatagcacatgcgaagctagcagctgaagcaggtgttgcaccagaaaagattttccttgtggaaaaaggagatgtcattaattacaacggtaaagatatgatattaaatgaaaaggtaaattcaggaaatattttaatagatggcattggtattggggatgtaggaaatatcgtgttgagagaccgtcatcttttagcagaagatggtatctttattgctgttgtaacgttagatcctaaaaatagacgtatagctgcgggacctgaaattcaatctcgtgggtttgtatatgtacgtgaaagtgaagacttattacgtgaagcagaagagaaagtacgtgaaatagtagaggctggtttacaagaaaaacgcatagaatggtctgaaattaaacaaaatatgcgtgatcaaattagtaaactattattcgaaagtacaaaacgtcgtcctatgattattccagtaatttctgaaatt |
162. | MNSEFIYGRVTNLGGKILSLIKKKNKDIRIIPLGGVGEIAKNMYIVEVDDEMFMLDAGLMFPEDEMLGIDIVIPDISYVLENKDKLKGIFLTHGHEHAIGAVSYVLEQLDAPVYGSKTLIALIKENMKARNIDKKVRYYTVNNDSIMRFKNVNISFFNTTHSIPDSLGVCIHTSYGAIVYTGEFKPDQSLHGHYAPDIKPMAEIGEEGVFVLISDSTEAEKPGYNTPENVIEHHMYDAFAKVRGRLIVSCYASNFIRIQQVLNIASKLNRKVSFLGRSLESSFNIARKMGYFDIPKDLLIPITEVDNYPKNEVIIIATGMWGEPVEALSQMAQHKHKIMNIEEGDSVFLAITASANMEVIIANTLNELVRAGAHIIPNNKKIEASSHGCMEELKMNINIMXPEYFIPVQGEFKMQIAHAKLAAEAGVAPSKIFLVEKGDVINYNGKDMILNEKVNSGNILIDGIGIGDVGNIVLRDRHLLAEDGIFIAVVTLDPKNRRIAAGPEIQSRGFVYVRESEDLLREAEEKVREIVEAGLQEKRIEWSEIKQNMRDQISKLLFESTKRRPMIIPVISSI |
163. | atggaaataacaatgcctaagttaggtgagagtgttcatgaaggcaccattgaacaatggttagtttctgttggtgatcatattgatgaatatgaaccattatgtgaagttattacagataaagtgacagctgaagtcccttccacgatatcaggaacaattacagaaattttagttgaagcggggcagacagtagctattgatacaattatctgtaaaattgaaactgctgatgaaaagacaaatgaaacaactgaagagatacaagcaaaagtggatgagcatactcagaaatctactaaaaaagctagtgcaacagtggaacagacatctactgctaaacaaaatcaaccacgtaataatggtcgcttttcacctgttgtatttaaactcgcttcagagcatgacattgatttatcacaagttgtaggtagtggatttgaaggtcgtgtaactaagaaggatataatgtcagttattgaaaatggtggtaccacagctcaatctgacaaacaagttcaaacaaaatcaacatcagtagatacatcaagtaaccaatcatctgaagacaatagtgaaaacagcacaataccagtaaatggtgtgcgtaaagcaattgcgcaaaatatggttaatagtgtaacagagattccacatgcatggatgatgattgaagtagatgctacaaatcttgtgaaaacgagaaatcattataaaaacagctttaaaaataaagaaggatataatctaacgttctttgctttctttgtaaaagctgtagcagatgctttaaaagcatatcctttattaaatagtagctggcaaggaaatgaaattgtcttacataaagacattaatatttcaattgctgttgctgatgaaaataaattatacgtacctgtgattaagcatgcagacgaaagcaatcaaaggtatagctagagagaaattaatactttagcaacgaaagcgcgtaataagcaattgacagctgaagatatgcagggcggtacatttacggtaaataatactggtacatttggttcagtatcatcatggggtattataaatcatccacaagcagcgattttacaagtagaatcaatcgttaaaaagccagtagtaattaatgatatgattgcaattcgtaacatggttaatttatgtatttcaattgatcatcgtattttagatggtttacaaacaggtaaatttatgaatcatattaaacagcgtatcgaacagtatactttagaaaatacaaatatatat |
164. | MEITMPKLGESVHEGTIEQWLVSVGDHIDEYEPLCEVITDKVTAEVPSTISGTITEILVEAGQTVAIDTIICKIETADEKTNETTEEIQAKVDEHTQKSTKKASATVEQTSTAKQNQPRNNGRFSPVVFKLASEHDIDLSQVVGSGFEGRVTKKDIMSVIENGGTTAQSDKQVQTKSTSVDTSSNQSSEDNSENSTIPVNGVRKAIAQNMVNSVTEIPHAMMMIEVDATNLVKTRNHYKNSFKNKEGYNLTFFAFFVKAVADALKAYPLLNSSMQGNEIVLHKDINISIAVADENKLYVPVIKHADEKSIKGIAREINTLATKARNKQLTAEDMQGGTFTVNNTGTFGSVSSMGIINHPQAAILQVESIVKKPVVINDMIAIRNMVNLCISIDHRILDGLQTGKFMNHIKQRIEQYTLENTNIY |
165. | |
166. | |
167. | atggaggacaacatgatttatgcaggtattttagcaggaggtattggttcgagaatggggaacgtgccattaccaaaacaatttttagatattgataataaaccgattttaatccatacaattgagaagttcattttagtgagtgaatttaatgagattattatcgcaacgccagcacagtggatttcccatacacaggatattttaaaaaaatataacattacagatcaacgtgtcaaagtagttgcaggtggtacggatcgaaatgaaacaattatgaacattatcgaccatattcgcaatgtaaatggaattaataatgatgatgtgattgtactcatgatgccgtaaggaccatttttaactcaacgtattattaaagagaacattgaagtagagcagcaaatatggtgcgtagatacagtcattgaagcaattgatacgattgtaatgtctaaagataaacagaacatacacagtatccctgtaaggaatgaaatgtatcaaggccaaacaccacaatcatttaatattaaattattacaagatagttatcgcgccttaagtagtgaacaaaaagaaatcttatcagatgcatgtaaaatcattgtcgaatctggacatgcagttaaattggtacgtggagaactatacaacattaaagtgacaacaccgtatgatttaaaagtagcaaatgccattattcaaggtgatattgccgatgat |
168. | MEDNMIYAGILAGGIGSRMGNVPLPKQFLDIDNKPILIHTIEKFILVSEFNEIIIATPAQWISHTQDILKKYNITDQRVKVVAGGTDRNETIMNIIDHIRNVRGINNDDVIVTHDAVRPFLTQRIIKENIEVAAKYGAVDTVIEAIDTIVMSKDKQNIHSIPVRNEMYQGQTPQSFNIKLLQDSYRALSSEQKEILSDACKIIVESGHAVKLVRGELYNIKVTTPYDLKVANAIIQGDIADD |
169. | atgataatatattggtgtatgacagttaatggagggaacgaaatgaaagctttattacttaaaacaagtgtatggctcgttttgctttttagtgtaatgggattatggcaagtctcgaacgcggctgagcagcatacaccaatgaaagcacatgcagtaacaacgatagacaaagcaacaacagataagcaacaagtaccgccaacaaaggaagcggctcatcattctggcaaagaagcggcaaccaacgtatcagcatcagcgcagggaacagctgatgatacaaacagcaaagtaacatccaacgcaccatctaacaaaccatctacagtagtttcaacaaaagtaaacgaaacacgcgacgtagatacacaacaagcctcaacacaaaaaccaactcacacagcaacgttcaaattatcaaatgctaaaacagcatcactttcaccacgaatgtttgctgctaatgcaccacaaacaacaacacataaaatattacatacaaatgatatccatggccgactagccgaagaaaaagggcgtgtcatcggtatggctaaattaaaaacagtaaaagaacaagaaaagcctgatttaatgttagacgcaggagacgccttccaaggtttaccactttcaaaccagtctaaaggtgaagaaatggctaaagcaatgaatgcagtaggttatgatgctatggcagtcggtaaccatgaatttgactttggatacgatcagttgaaaaagttagagggtatgttagacttcccgatgctaagtactaacgtttataaagatggaaaacgcgcgtttaagccttcaacgattgtaacaaaaaatggtattcgttatggaattattggtgtaacgacaccagaaacaaagacgaaaacaagacctgaaggcattaaaggcgttgaatttagagatccattacaaagtgtgacagcggaaatgatgcgtgtttataaagacgtagatacatttgttgttatatcacatttaggaattgatccttcaacacaagaaacatggcgtggtgattacttagtgaaacaattaagtcaaaatccacaattgaagaaacgtattacagttattgatggtcattcacatacagtacttcaaaatggtcaaatttataacaatgatgcattggcacaaacaggtacagcacttgcgaatatcggtaagattacatttaattatcgcaatggagaggtatcgaatattaaaccgtcattgattaatgttaaagacgttgaaaatgtaacaccgaacaaagcattagctgaacaaattaatcaagctgatcaaacatttagagcacaaactgcagaggtaattattccaaacaataccattgatttcaaaggagaaagagatgacgttagaacgcgtgaaacaaatttaggaaacgcgattgcagatgctatggaagcgtatggcgttaagaatttctctaaaaagactgactttgccgtgacaaatggtggaggtattcgtgcctctatcgcaaaaggtaaggtgacacgctatgatttaatctcagtattaccatttggaaatacgattgcgcaaattgatgtaaaaggttcagacgtctggacggctttcgaacatagtttaggcgcaccaacaacacaaaaggacggtaagacagtgttaacagcgaatggcggtttactacatatctctgattcaatccgtgtttactatgatataaataaaccgtctggcaaacgaattaatgctattcaaattttaaataaagagacaggtaagtttgaaaatattgatttaaaacgtgtatatcacgtaacgatgaatgacttcacagcatcaggtggcgacggatatagtatgttcggtggtcctagagaagaaggtatttcattagatcaagtactagcaagttatttaaaaacagctaacttagctaagtatgatacgacagaaccacaacgtatgttattaggtaaaccagcagtaagtgaacaaccagctaaaggacaacaaggtagcaaaggtagtaagtctggtaaagatacacaaccaattggtgacgacaaagtgatggatccagcgaaaaaaccagctccaggtaaagttgtattgttgctagcgcatagaggaactgttagtagcggtacagaaggttctggtcgcacaatagaaggagctactgtatcaagcaagagtgggaaacaattggctagaatgtcagtgcctaaaggtagcgcgcatgagaaacagttaccaaaaactggaactaatcaaagttcaagcccagaagcgatgtttgtattattagcaggtataggtttaatcgcgactgtacgaogtagaaaagctagc |
170. | MIIYWCMTVNGGNEMKALLLKTSVWLVLLFSVMGLWQVSNAAEQHTPMKAHAVTTIDKATTDKQQVPPTKEAAHHSGKEAATNVSASAQGTADDTNSKVTSNAPSNKPSTVVSTKVNETRDVKTQQASTQKPTHTATFKLSNAKTASLSPRMFAANAPQTTTHKILHTNDIHGRLAEEKGRVIGMAKLKTVKEQEKPDLMLDAGDAFQGLPLSNQSKGEEMAKAMNAVGYDAMAVGNHEFDFGYDQLKKLEGMLDFPMLSTNVYKDGKRAFKPSTIVTKNGIRYGIIGVTTPETKTKTRPEGIKGVEFRDPLQSVTAEMMRIYKDVDTFVVISHLGIDPSTQETWRGDYLVKQLSQNPQLKKRITVIDGHSHTVLQNGQIYNNDALAQTGTALANIGKITFNYRNGEVSNIKPSLLNVKDVENVTPNKALAEQINQADQTFRAQTAEVIIPNNTIDFKGERDDVRTRETNLGNAIADAMEAYGVKNFSKKTDFAVTNGGGIRASIAKGKVTRYDLISVLPFGNTIAQIDVKGSDVWTAFEHSLGAPTTQKDGKTVLTANGGLLHISDSIRVYYDINKPSGKRINAIQILNKETGKFENIDLKRVYHVTMNDFTASGGDGYSMFGGPREEGISLDQVLASYLKTANLAKYDTTEPQRMLLGXPAVSEQPAKGQQGSKGSKSGKDTQPIGDDKVMDPAKKPAPGKVVLLLAHRGTVSSGTEGSGRTIEGATVSSKSGKQLARMSVPKGSAHEKQLPKTGTNQSSSPEAMFVLLAGIGLIATVRRRKAS |
171. | atgcaagagtaccaaaaatcgttaaatacgcttaaaaagcctataaatgttccgtatgagcaagaaactgaaaaagtaggtggtttatttagcaaagaaatacaagaaactggaaatgttgtaataagccaaaaagatttcaatgaatttcagaaacagataaaagctgctcaagatatttcggaagattacgagtatataaagtctggtagagccttagatgataaagataaggaaatacgagagaaagatgatttattaaataaagcagttgagcgtattgaaaacgcagacgataattttaaccaactttacgaaaatgcaaagccacttaaagagaatatagaaatagcgttaaagcttttaaaaatcttactaaaagagttagaacgagttttaggaagaaatacctttgcggaaagagttaataagttaacagaagatgaaccaaaactaaatggtttagcaggaaactgagataaaaaaatgaatccagaattatattcagaacaggaacagcaacaagaacaacaaaagaatcaaaaacgagatagaggtatgcactta |
172. | MQEYQKSLNTLKKPINVPYEQETEKVGGLFSKEIPETGNVVISQKDFNEFQKQIKAAQKQSEDYEYIKSGRALDDKDKEIREKDDLLNKAVERIENADDNFNQLYENAKPLKENIEIALKLLKILLKELERVLGRNTFAERVNKLTEDEPKLNGLAGNLDKKMNPELYSEQEQQQEQQKNQKRDRGMHL |
173. | atgaagatgataaacaaattaatcgttccggtaacagctagtgctttattattaagcgcttgtggcgctagtgccacagactctaaagaaaatacattaatttcttctaaagctggagacgtaacagttgcagatacaatgaaaaaaatcggtaaagatcaaattgcaaatgcatcatttactgaaatgttaaataaaattttagctgataaatataaaaataaagttaatgataagaagattgacgaacaaattgaaaaaatgcaaaagcaatacggcggtaaagataaatttgaaaaggcccttcaacagcaaggtttaacagccgataaatataaagaaaatttacgtactgctgcttatcacaaagaattactatcagataaaattaaaatctctgattctgaaattaaagaagacagcaagaaagcttcacacattttaattaaagttaaatctaagaaaagcgacaaagaaggcttagatgataaagaagcgaaacaaaaagctgaagaaattcaaaaagaagtttcaaaagatccaagtaaatttggtgaaatcgctaaaaaagaatcaatggatactggttcagctaaaaaagatggcgaattaggttatgttcttaaaggacaaactgataaagattttgaaaaagcactatttaagcttaaagatggtgaagtatcagaggttgttaaatcaagctttggatatcatattattaaagctgataaaccaacagactttaacagtgaaaaacaaagcctgaaagaaaaattagtcgatcagaaagtacaaaaaaatccaaaattattgactgatgcatacaaagatctattaaaagaatacgatgttgactttaaagatcgtgatattaaatcagttgtcgaagataaaatcttaaaccctgaaaaacttaaacaaggtggcgcacaaggcggacaatccggcatgagccaa |
174. | MKMINKLIVPVTASALLLGACGASATDSKENTLISSKAGDVTVADTMKKIGKDQIANASFTEMLNKILADKYKNKVNDKKIDEQIEKMQKQYGGKDKFEKALQQQGLTADKYKENLRTAAYHKELLSDKIKISDSEIKEDSKKASHILIKVKSKKSDKEGLDDKEAKQKAEEIQKEVSKDPSKFGEIAKKESMDTGSAKKDGELGYVLKGQTDKDFEKALFKLKDGEVSEVVKSSFGYHIIKADKPTDFNSEKQSLKEKLVDQKVQKNPKLLTDAYKDLLKEYDVDFKDRDIKSVVEDKILNPEKLKQGGAQGGQSGMSQ |
175. | atgcttttagtattagctggttgctctaattctaacgataataatgaaagtaaaaaagatgacgcagacaatggtaagaaacaagagattcaagttgcagcggcagcaagtttaacagatgtaaccaagaaattagcttcagaatttaaaaaagagcataaaaatgctgatattaaatttaactatggtggatcaggggcattaagaaaacaaattgaatcaggcgcacctgttgacgtatttatgtctgcaaatactaaagatgtagatgcattaaaagacaagaataaagcgcatgatacatataaatatgcgaaaaatagtctagtattaattggtgataaagattcaaattacacttcagtaaaagacttaaaagacaatgataaattagcattaggtgaagtgaaaactgtaccagcaggaaaatatgcgaaacagtatttagataacaataacttatttaaagaagtcgaaagtaaaatcgtttatgctaaagatgtaaaacaagtattaaattatgttgaaaagggtaatgcgaaacaaggttttgtgtataaaactgacttatataaacaaaataaaaaaattgatactgtaaaagtaattaaagaagtagaacttaagaagccaatcacatacgaagctggtgccacaccagatagtaaattagcaaaagagtggatggaattcttaaaatcagataaagctaaagaaatactaaaagaataccactttgcagca |
176. | MLLVLAGCSNSNDNNESKKDDADNGKKQEIQVAAAASLTDVTKKLASEFKKEHKNADIKFNYGGSGALRKQIESGAPVDVFMSANTKDVDALKDKNKAHDTYKYAKNSLVLIGDKDSNYTSVKDLKDNDKLALGEVKTVPAGKYAKQYLDNNNLFKEVESKIVYAKDVKQVLNYVEKGNAKQGFVYKTDLYKQNKKIDTVKVIKEVELKKPITYEAGATSDSKLAKEWMEFLKSDKAKEILKEYHFAA |
177. | ttggcatacacatacactttaaaagatattattgaaattacaggtgtaactaaaagaactttacattattacgatgaaataggattattagttccagataaaaatgataaaaattatcgcgtttataaacagcaagacttagaaaaattacaaaagattttaatactcaagtcttttgattttgatatcgctaaaataaaacaatacatttcgtatgataatgaacaattgcgaaagttattatcagagcaaataagcaagttagataaaaagatttctgacttacaattaattagacgctctgtatgtgaatttattaaaggactctctctaatagataccagcattttaaacaagacactacagtcacaatatgataaagaagcatctataaaatatggtcatacgaaagcatatcaatcatttattagacgtaaagacagcttacaatcgcaggatatcagacataaattgacaactatcttcaataaatttaatcatatgtctttgagtcattatccaatccaagattgtagtgatctcgtatttgagtggaaggcatttatgaacactatcgctgattttgatgatgaaacattatgctgtattgctaaaacatatgaagatgatacgcgtttcaaagattactttaattcatatgataatcaaaatttagcatcatacatttcagaagctgttaattattttttgagcaatgtgaataagagcgacaatttt |
178. | MAYTYTLKDIIEITGVTKRTLHYYDEIGLLVPDKNDKNYRVYKQQDLEKLQKILILKSFDFDIAKIKQYISYDNEQLRKLLSEQISKLDKKISDLQLIRRSVCEFIKGLSLIDTSILNKTLQSQYDKEASIKYQHTKAYQSFIRRKDSLQSQDIRHKLTTIFNKFNHMSLSHYPIQDCSDLVFEWKAFMNTLADFDDETLCCIAKTYEDDTRFKDYFNSYDNQNLASYISEAVNYFLSNVNKSDNF |
179. | atggcaaaaataaaagcaaatgaagcattagttaaagcattaaacaagcatgggatagatcacttgtatggtattccaggagactcaatcgacgcagtagtcgatagtttacgtacagtgagagatcaatttaaattttatcatgtacgtcatgaagaagtagcaagcttagcggctgctggttacacaaaattaactggtaaaatcggtgtggcattaagtatcggtggccctggtttaattcatttattaaatggtatgtatgatgccaaaatggataatgtaccgcaattaatattatctggacaaacgaatagtacagcacttggaacgaaagcattccaagaaacaaatttacaaaaattatgtgaagatgtagccgtttataatcaccaaattgaaaaaggtgacaatgtgtttgaaatcgttaacgaagcaattcgtacggcatatgaacaaaaaggtgtagctgttgttatttgtcctaacgacttattaactgaaaaaattaaagatacaacgaataaaccagtagatacatcaagaccaacagtagtatcaccaaaatataaagacatcaaaaaagcggttaaactaattaataaaagtaaaaagcctgtcatgttaattggtgtaggtgcgaaacatgcgaaagatgagctacgtaggtttattgaaatggctaaaattcctgtcattcattcattaccagctaaaacaatcttgccggatgatcatccacatagtatcggtaacttaggtaaaatcggtaccaaaacatcttatcaaacaatgcaggaagcggatttattaattatggttggtacaaactatccatatgtggattacttacctaagaaaaatattaaagccattcaaattgacacaaatcctaaaaatatcggacatcgtttcaatattaatgtaggaattgttggagatagtaaaattgcgttgcatcagttaactgaaaatattaaacatgttgctgaaagaccattcttaaacaaaacgttagaacgtaaagcggtttgggataaatggatggaacaagataaaaataataatagtaaaccattacgtccagaacgattaatggcatcaatcaataaatttattaaagatgatgcagtgatttcagcagatgtaggtacagcaacagtttggtcaactcgatacttaaaccttggtgtaaataacaagttcatcatttcaagttggttaggtacaatgggttgcggtcttccaggtgcaattgcatcaaaaattgcatatccaaatagacaagccatcgcaattgctggtgacggtgcattccaaatggtaatgcaagacttcgctacagcagtacaatatgatttacctttaactgtatttgtacttaataacaaacagttagcatttattaaatatgaacaacaagcagctggtgaattagaatatgcagttgatttttctgatatggatcatgcaaaatttgctgaggcagcaggtggtaaaggttatacaattaagagtgctagcgaagtagatgctatagtcgaagaggcattagcacaagatgtaccaacgattgtagatgtatatgttgatcctaatgctgcgccattaccaggtaaaattgtaaatgaagaagcgcttggttatggtaagtgggcatttagatcaattactgaagataaacatttagatttagatcaaattccaccaatttcagtggcagcaaaacgtttctta |
180. | MAKIKANEALVKALQAWDIDHLYGIPGDSIDAVVDSLRTVRDQFKFYHVRHEEVASLAAAGYTKLTGKIGVALSIGGPGLIHLLNGMYDAKMDNVPQLILSGQTNSTALGTKAFQETNLQKLCEDVAVYNHQIEKGDNVFEIVNEAIRTAYEQKGVAVVICPNDLLTEKIKDTTNKPVDTSRPTVVSPKYKDIKKAVKLINKSKKPVMLIGVGAKHAKDELREFIEMAKIPVIHSLPAKTILPDDHPYSIGNLGKIGTKTSYQTMQEADLLIMVGTNYPYVDYLPKKNIKAIQIDTNPKNIGHRFNINVGIVGDSKIALHQLTENIKHVAERPFLNKTLERKAVWDKWMEQDKNNNSKPLRPERLMASINKFIKDDAVISADVGTATVWSTRYLNLGVNNKFIISSWLGTMGCGLPGAIASKIAYPNRQAIAIAGDGAFQMVMQDFATAVQYDLPLTVFVLNNKQLAFIKYEQQAAGELEYAVDFSDMDHAKFAEAAGGKGYTIKSASEVDAIVEEALAQDVPTIVDVYVDPNAAPLPGKIVNEEALGYGKWAFRSITEDKHLDLDQIPPISVAAKRFL |
181. | gtagtagtttagggcttgcaacgcac |
182. | caccatcatagaacatacaattgctagc |
183. | ctgatactggacaacatagaga |
184. | aagtaacgttatctttcgaatggt |
185. | atttctggcactcaagtatatcaagac |
186. | tggcttaggtgttggtgtaggc |
187. | ataatgcaactacaactcagcc |
188. | ttgatcgttgatgtattttgattagat |
189. | ctacaataactacagccgttaca |
190. | gtgaatgaagttataaccagcag |
191. | cacgctaaagcatcagtgacaga |
192. | agcattttgatgtgttgctgttgtgtt |
193. | gaatccccaagcacctaaac |
194. | gtaaacgttgatcaagcacact |
195. | tttgcaataacagcaacatctggtgcag |
196. | gaaacttctgaagctggaattgtacgg |
197. | atgagaaaaactaaaattgtatgtacaattggaccagcttcagaatcagaagaaatgattgagaaattaatcaatgctggtatgaacgttgcacgattaaacttttcacatggtagtcatgaagagcataaaggtagaattgatacaattcgtaaagtagctaaaagattagacaaaattgtagcaattttattagatacaaaaggtccagaaattcgtacgcataatatgaaagacggtatcattgaacttgaacgtggcaacgaagttattgttagcatgaatgaagttgaaggaacacctgaaaagttctcagtaacatatgaaaacttaattaacgatgttcaagtaggttcatacattttacttgatgatggcttaattgaattacaagttaaagatattgaccatgctaaaaaagaagttaaatgtgatattttaaactctggtgagcttaaaaacaaaaaaggtgttaacttacctggcgtaagagtaagtttacctggtattacagaaaaagatgctgaagatatccgtttcggtattaaagaaaatgttgacttcattgcagcaagtttcgtacgtcgtcctagtgatgttttagaaattcgtgaaattttagaagaacaaaaagctaacatttcagtattccctaaaattgaaaaccaagaaggtattgataatattgcggaaattcttgaagtgtctgatggtttaatggttgcacgtggtgacatgggtgttgaaattccacctgaaaaagtaccaatggttcaaaaagatttaatcagacaatgtaacaaattaggtaaaccagttattacagctacacaaatgttagattctatgcaacgtaacccacgtgctacacgtgcagaagctagtgacgttgccaacgcaatctatgatggtacagatgcagtaatgttatctggtgaaactgctgctggtttatatcctgaagaagctgttaaaacaatgagaaatattgctgtatcagctgaagcagcccaagattacaaaaagttattgtcagatcgtactaaattagttgaaacttcattagtgaatgctatcggtatttcggttgcacatacagctttaaacttaaatgttaaagcaattgtagctgctactgaaagtggttcaacggcacgtactatctccaaatatcgtccacattcagacattattgcggtgactccaagtgaagaaactgcacgtcaatgttcaattgtttggggagttcaacctgtagttaaaaaaggacgtaagagtacagatgcattgttaaacaatgcagttgcaacagctgttgaaactggtagagtatctaatggtgatttaatcattattactgctggtgtaccaactggtgaaactggaactactaatatgatgaaaatccacctagttggtgacgaaattgctaatggtcaaggtattggacgtggatcagttgttggtactacgttagttgctgaaactgttaaagatttagaaggtaaagatttatctgacaaagttatcgttactaactcaatcgatgaaacgtttgtaccttatgtagaaaaagctttaggcttaattacagaagaaaatggtattacatcaccaagtgcaattgttggtttagaaaaaggtattccaacagttgtaggtgtagaaaaagctgttaaaaacataagcaataacatgttagttacgattgatgctgctcaaggtaaaatctttgaaggatatgcaaacgtacta |
198. | atgcaattcgataatattgacagtgctttaatggctttaaaaaatggagaaccaattattgtagtagatgatgagaatcgtgaaaatgaaggtgatttagtagcggttactgaatggatgaacgataataccattaattttatggcgaaagaagcaaggggattaatatgcgcaccagtgtctaaagatattgcacaacgtttggatttggtacaaatggttgatgataactccgacatctttggtacgcaatttacagtgagtattgatcatgtagatacaacaacaggaattagtgcttatgaacgtacattgactgccaaaaagctcattgatcctagtagtgaagctaaagattttaatcgtcctggtcatttatttccattagtagcacaagataaaggcgtattagctagaaatggacacacagaagcggctgttgatttagctaaacttactggtgccaagcccgctggtgtcatttgtgagattatgaatgatgacggcacgatggcgaaaggacaagatttacaaaagtttaaagaaaaacatcaattaaagatgattacgattgatgatttaattgaatatcgtaaaaaattagaaccagaaattgaatttaaggcaaaagtgaaaatgcctacagatttcggaacatttgatatgtatggttttaaagcgacatacacagatgaagagatagttgtactgacaaaaggtgcaattcgacaacatgaaaatgtacgcttacattctgcgtgccttacaggcgatattttccatagtcaacgttgtgattgtggtgctcaacttgaatcgtctatgaagtatatcaatgaacatggtggcatgattatttatctacctcaagaaggtcgtggcataggattgttaaacaaattacgcgcatatgaattaattgagcaaggatatgatacagtaactgcaaatttagcattaggttttgatgaagatttgcgagattatcatattgctgcacagattttaaaatattttaacatcgaacatatcaatttattaagtaataatccaagtaaatttgagggattaaaacaatatggcattgatattgcagaaagaattgaagttatcgtaccagaaacggtacataatcatgattatatggaaacgaaaaaaataaaaatgggtcatttaata |
199. | atgaaaatgaaaaaattagtcaaatcatcagttgcttcatcaattgcactgcttttgctatcgaatacagttgatgcagctcaacatatcacacctgtaagcgagaaaaaagtagatgacaaaatcactttatacaaaacaacagcaacatctgataatgataaattgaatatttctcaaattttaacgtttaatttcattaaggataaaagttatgacaaagatacgttagtacttaaggcagccggaaacattaattcaggttataaaaagcctaatccaaaagattacaattactcacagttttattggggcggtaagtataatgtttcggttagttcagaatcaaatgatgctgtaaatgttgttgactatgcacctaaaaatcaaaatgaagaattccaagttcaacaaacattaggttattcttatggcggagatattaatatatctaatggcttatcaggtggattaaatggatcaaaatcattttcagaaacgataaattataaaacaagaaagttacagaactacgattgatagaaaaacaaatcataaatcaattggctggggtgttgaggcgcacaaaattatgaataatggttggggaccatatggtagagatagttatgacccaacatatggtaatgaactgtttttaggcggtagacaaagtagttcaaatgctggtcaaaatttcttgccaacacatcaaatgcctttattggcgcgtggtaactttaacccagaatttataagcgtactttctcataaacaaaatgatacaaaaaaatctaaaatcaaagtaacttaccaaagagaaatggatagatatactaatcaatggaatcgactacactgggttggtaataactacaaaaatcaaaatacagtaacgtttacatctacttatgaagttgactggcaaaaccatactgttaaattaatcggtacggattctaaagaaactaatcctaggata |
200. | AtgaagaaaaaagcgttactaccattatttttaggtattatggtctttttggctggttgtGactattctaaacctgaaaaacgtagtgggtttttctacaatacattcgtagatccaatgAaaaatgtattggattggttgggaaataacttattaaacgacaattatggtttagctattAttatccttgtattggtaattcgtattattttattaccattcatgttgtcaaactataaaAatagtcatatgatgcgtcaaaaaatgaaagttgcaaagccagaagttgaaaaaattcaaGaaaaagtgaaacgtgcgcgtacacaagaagaaaaaatggctgcaaaccaagaattaatgCaagtatataaaaagtatgacatgaacccgattaagagtatgttgggttgtttaccaatgCtaatccaattaccaatcatcatgggattatactttgtacttaaagaccaacttgtagatGgtttgtttaaatatccacacttcttatggttcgatttaggacgtcctgatatttggattAcaattattgccggtgttttatactttatccaagcatatgtatcaagtaaaacgatgccaGacgaacaacgtcaaatgggttacatgatgatggtcatttcaccaattatgattatctggAtttcattaagctcagcatcagcacttggtttgtactggtcagtcagtgcggcgttccttGtagttcaaacacactttgcgaacatttattatgaaaaagtcgctaaaaaagaagtacaaCctttcattgaagcgtatgaaagagagcacaacggcggcagcaataaaaaaggcaaaaacacacaagttgtgtctaaaaagaaaaagaaa |
201. | atgaatttattcagacaacaaaaatttagtatcagaaaatttaatgtcggtattttttcagctttaattgccactgttacttttatatctactaacccgacaacagcgtctgcagcagagcaaaatcagcctgcacaaaatcaaccagcacaaccagctgatgccaatacacagcctaacgcaaatgctggtgctcaagctaatcctacagcacagccagctgcacctgccaaccaaggacaaccagcagtacaaccagcaaaccaaggtggacaggctaatccagcaggaggagcagcacaaccaaatacacaaccagctggacaaggtaatcaagctgatccgaataacgctgcacaagcacaacctggaaatcaagcaacaccggcaaaccaagcaggtcaaggaaataaccaagcaacacctaataataatgcaacaccggcaaatcaaacacagccagcgaatgctccagcagcagcgcaaccagcagcacctgtagcagcaaacgcacaaactcaagatccaaatgctagcaatactggtgaaggcagtattaatacgacattaacatttgatgatcctgccatatcaacagatgagaatagacaggatccaactggtaactgttacagataaagtaaatggttttcattaattaacaacggtaagattggtttcgttaactcagaattaagacgaagcgatatgtttgataagaataaccctcaaaactatcaagctaaaggaaacgtggctgcattaggtcgtgtgaatgcaaatgattctacagatcatggtaactttaacggtatttcaaaaactgtaaatgtaaaaccagattcagaattaattattaactttactactatgcaaacgaatagtaagcaaggtgcaacaaatttagttattaaagatgctaagaaaaatactgaattagcaactgtaaatgttgctaagactggtactgcacatttatttaaagtaccaactgatgctgatcgtttagatttacaatttattcctgacaatacagcagttgctgatgcttcaagaattacaacaaataaagatggttataaatactattcattcattgataatgtaggtctattctcaggatcacatttatatgtcaaaaatagagatttagcaccgaaagcaactaacaataaagaatatactattaatactgaaatcggtaacaatggtaattttggtgcttcattaaaagcagatcaatttaaatatgaagtaacattaccacaaggtgtaacttacgttaataattcattaactacaacattccctaattggtatgaagacagtacagtattgaaaaatatgactgttaattatgatcaaaatgcaaataaagttacatttacaagccaaggtgtgacaacggcacgtggtacacacactaaagaagttttattcccagataaatctttaaaattatcatataaagttaatgttgcgaatatcgatacacctaaaaatattgattttaatgaaaaattaacatatcgtactgcttcagatgttgtaattaataatgcgcaaccagaagttacactaactgcagatccattttcagtagcggttgaaatgaacaaagatgcgttgcaacaacaagtaaactcacaagttgataatagtcattacacaacagcatcaattgcagaatacaataaacttaaacaacaagcagatactattttaaatgaagatgcgaatcatgttaaaactgcaaatcgtgcatctcaagcggatattgatggtttagtaactaaattacaagctgcattaattgataatcaagcagcaattgctgaattagatactaaagctcaagaaaaggttacagcagcacaacaaagtaaaaaagttacgcaagatgaagttgcagcacttgtaactaaaattaacaatgataaaaataatgcaatcgcagaaattaataaacaaactacagcacaaggtgtcacaactgaaaaagataatggtatcgcagtgttagaacaagatgtgattacaccaacagttaaacctcaagcgaaacaagatattatccaagcagttacaactcgtaaacaacaaattaaaaagtcaaatgcatcattacaagatgaaaaagatgtagcaaatgataaaattggtaaaattgaaacaaaggcaattaaagatattgatgcagcaacaacaaatgcacaagtagaagccattaaaacaaaagcaatcaatgatattaatcaaactacacctgctacaacagctaaagcagcagctcttgaagaatttgacgaagttgttcaagcacaaattgatcaagcacctttaaatcctgatacaacaaatgaagaagtagcggaagctattgaacgtattaatgcagctaaagtttctggtgttaaagcaattgaagcgacaacgactgcacaagatttagaaagagttaaaaacgaagaaatctcaaaaattgaaaatattactgactctacgcaaacaaaaatggatgcctataatgaagttaaacaagctgcaacagctagaaaagctcaaaatgctacagtttcaaatgcaacaaatgaagaagtagcagaagctgatgcagcagtagatgcagctcaaaagcaaggtttacatgacatccaagttgttaaatcaaaacaggaagttgctgatacaaaatcaaaagtattagataaaatcaatgcaattcaaacacaagcaaaagttaaacctgcagctgatacggaagtagaaaacgcatataatacacgtaaacaagaaattcaaaatagcaatgcttcaactacagaagaaaaacaagctgcatatacagaattagatactaaaaagcaagaagcaagaacaaatcttgatgctgcaaatacaaacagtgatgtaacaacagctaaagacaatagtattgctgcaattaatcaagttcaagctgccacaactaagaaatcggatgcaaaagcggaaatcgctcaaaaagcaagtgaacgtaaaacagcaattgaagcaatgaatgattcgactactgaagaacaacaagcagcgaaagacaaagtggatcaagcagtagttactgcaaacgctgatatagataatgctgcagcaaacaatgatgtggataatgcaaaaactacaaatgaagctacaatcgcagccattacacctgatgcaaatgttaaaccagcagcaaaacaagcaattgcagataaagtacaagctcaagaaacagcaattgatggaaataacggctcaacaactgaagaaaaagcagctgctaaacaacaagttcaaactgaaaaaacaacagctgatgccgcaatagatgcagcacatacaaatgcggaagttgaagcggctaaaaaagcagcaattgctaaaattgaagcgattcagccagcaacaacaactaaagataatgcgaaagaagcaattgctacgaaagcgaatgaacgtaaaacagcaatcgctcaaacgcaagacattactgctgaagaaattgcagcggctaatgcggacgtagataatgctgtgacacaagcaaatagcaacattgaagctgctaatagtcaaaatgatgtagaccaagcgaaaacgacaggtgaaaatagtattgatcaagtaacaccaacagttaataaaaaagcaactgcacgtaatgaaatcacagcaattttaaataacaaattgcaagagattcaagctacgccagatgcaacagatgaagaaaaacaagcagctgatgctgaagcaaatactgaaaatggtaaagcaaatcaagccatttcagcagcaactactaacgcacaagttgatgaagctaaagcaaatgcagaagcagcgattaatgcggtaacaccaaaagttgtgaagaaacaagcggctaaagatgaaattgatcaattacaagcaacgcaaacaaatgttatcaataatgatcagaacgctacaacagaagaaaaagaagcagctattcaacaattagcaacagcagttacagacgcgaaaaataatattacagctgcaactgatgataatggtgtagatcaggcgaaagacgctggaaagaattcaattcaaagcacgcaaccagcaacagcggttaaatcaaatgctaaaaatgatgttgatcaagctgtgacaactcaaaatcaagcaattgataatacaactggtgctacaactgaagagaaaaatgcagcaaaagatttagttttaaaagctaaagaaaaagcgtatcaagatatcttaaatgcacaaacaactaatgatgttacgcaaattaaagatcaagcagttgctgatattcaaggtattactgcagatacaacaattaaagatgttgcgaaagatgaattagcaacaaaagcaaacgaacaaaaagcgcttattgcacaaactgcagatgcgactactgaagaaaaagaacaagcaaatcaacaagtagacgcacaattaacacaaggtaatcaaaatattgaaaatgcaaagtcaatcgatgatgtaaacactgcaaaagataatgcaattcaagcaattgacccaattcaagcatcaacagatgttaaaacgaatgcaagagcggaattgctaactgaaatgcaaaataaaataactgaaatacttaataataatgagactactaatgaagaaaaaggtaacgatattggaccagttagagcagcatatgaagaaggtttaaataatattaatgcagcaactactacaggtgatgtaactactgctaaagatacagcagtacaaaaagttcaacaacttcatgcaaatcatgttaagaaaccagcaggtaaaaaagaattagatcaagctgcagctgataagaaaacacaaatagaacaaacaccaaatgcatcacaacaagaaattaatgatgaaaaacaagaagttgatactgaattaaatcaagcgaaaacaaatgtcgatcaatcatcaacaaatgaatatgttgataatgcagttaaagaaggaaaagctagggttaatgcagttaaaacatttagtgagtacaaaaaagatgctttagctaaaattgaagatgcatataatgctaaagtaaacgaagcggataactctaacgcatcgacttcaagtgaaattgctgaagcgaaacaaaaacttgctgaattaaaacaaactgcggatcaaaatgttaatcaagctacttctaaagatgacattgaagttcaaattcataatgacttagataatattaacgattacacaattccaacaggtaaaaaagaatcagctacaacagatttatatgcttatgcagatcagaagaaaaataatatttcagctgacactaatgcaacacaagatgaaaagcaacaagcaattaagcaagttgaccaaaatgttcaaactgcattagaaagcattaataatggtgtggataatggtgacgttgatgatgcattaacacaaggtaaagcagcaattgatgctattcaagtagatgctactgttaaacctaaagcgaaacaagctattgaagttaaagcagaagatacgaaagaatctattgatcaaagt |
gaccagttaactgctgaagaaaaaactgaagcattagcaatgattaaacaaattacagatcaagctaaacaaggtattactgatgcaacaacaactgctgaagttgaaaaagcgaaagctcaaggacttgaagcatttgataacattcaaatcgactcaacagaaaaacaaaaagctatcgaagaattagaaactgcactagaccagattgaagcaggtgtaaatgtcaacgctgatgctacaactgaagaaaaagaagcgtttacgaatgctttagaagacattttatcaaaagcaactgaagatatttctgatcaaactacaaatgcagaaatcgctactgtcaaaaatagtgcgcttgaacaacttaaagcacaacgtattaatcctgaagttaagaaaaatgctttggaagcaatcagagaagtggttaacaagcaaatagaaataattaaaaatgcagatgcagatgcatcggcgaaagaaattgcacgtacggatttaggtagatattttgacagatttgctgataaattagataaaacacaaacaaatggcagaagttgctgaattacaaaatgtacgatacctgcaattgaagcgattgtgcctcagaatgatccagatgctaatgatactaataatggtatagataataatgatgcaacagcaaattcaaatgctaatgcaacaccagaaaatactggacaacctaacgtatctgagacgacagctaatggcaaagcagacgcttctccgacaacaccaaataatagtgatgcggcaacaggtgaaacaacagcaacatcagcaactgatgatgcaaatgataaaccgcaagctaataacaattctagtgtagatgcatcaacaaacagtccgacaatggataacgatgtaactagtaaaccagaagtagaatcaactaataacggcacaactgataaacctgtaacagaaactgataatgcaacgccagcagaaagcacaacaaataacaatagtacaactacagcaacaaacgagaatgcaccaacaggatcaacagcaacggctccaacaactgcgagcacagaagcagcatcatctgctgatagcaaagataatgcatctgtaaatgattcaaaacaaaatgctgaagtaaataatagtgctgaatctcaatcaactaatgacaaggttgcacaaccaaaatctgaaaataaagctaaggcagaaaaagatggtagtgattcaacaaatcaaagtatggttgaatcaacaactgaaacattgccttcagcagacataacagaaccaaatgtaccttctaatacatcaaaagataaagaagaaagtacgacaaatcaaactgatgcaggacaacttaagtctgaaactaacgttgcatctaacgaagcagataaatcgccaagcaaagctgatactgaagtttcgaataaaccatcaacatctgcatcttctGaagcaaaagaaaaaatgacttcaactaatcttagccaaaaagatgatacggcaacagcagatactaatgatacgcaaaaatcagttggttcagctgcaaacaataaagctacgcaaaacgacggtgccaatgcatctccagctacagtttcaaatggaagcaatagtgctaatcaagatatgcttaatgtaactaacactgacgaccaccaagctaagacaaaatcagctcaacaaggaaaagttaataaagctaaacaacaagctaaaactttaccagatactggtatgtcacataatgacgatttaccatatgctgaattagctctaggtgcaggtatggcattcttaattagaagattcactaagaaagaccaacaaactgaagaa |
202. | atgaaactaaaatcatttgttactgccactttagcattgggattattatcaacggtcggagctgcattaccgagtcacgaagcatctgcagatagtaataacggctataaagaaatgactgtggatggttatcacactgttccttacacaatttcagtagatggtattactgcattacatcgaacttactttatcttcccagaaaataaaaatgttctttatcaagaaattgacagtaaagtaaaaaatgaattagcttctcaacgtggtgttacaacagaaaaaattaataatgcccaaacagcaacttatacgcttactttgaatgatggtaataaaaaagtagtgaatctaaagaaaaatgacgacgctaaaaattcaattgatccaagtacaatcaaacagatacaaattgtagttaaa |
203. | atggctattaaaaatataagccaataacaaatggtcgtcgataatatgacttcgttagatttcgcagaaatcacgaaaactacacctgaaaagtcattattaaaaccgctaccgaaaaaagcgggacgtaacaaccaaggtaaattgactgtaagacaccatggtggtggacacaaacgtcaataccgtgttatcgatttcaaacgtaacaaagatggtatcaatgcaaaagttgattctattcaatatgattccaaaccgctcagcaacatcgctttagttgtatatgcagacggtgaaaaacgatatatcattgctcctaaaggattagaagtaggtcaaatcgttgaaagtggtgctgaagctgacatcaaagttggtaacgcattaccattacaaaacattccagttggtacagtagtacacaacatcgagcttaaacctggtaaaggtggacaaatcgctcgttcagctggtgcaagtgctcaagtacttggtaaagaaggtaaatacgtattaatcagattaagatctggtgaagttcgtatatcttatctacttgccgtgctacaatcggtccaagttggtaacctacaacacgaattagttaacgttggtaaagccggacgttcaagatggaaaggtatccgtccaacagttcgtgGttctgtaatgaaccctaacgatcacccacacggtggtggtgaaggtcgtgctcctatcggtagaccatctccaatgtcaccatggggtaaacctacgcttggtaagaaaactcgtcgtggtaaaaaatcatcagacaaacttatcgttcgtggacgtaagaaaaaa |
204. | atgttagtaaatacgtttaacccatttgataatttattattatcgtctttaattgcagcaataccgattgtactgtttttactatgtttaactgtttttaaaatgaaaggtatttatgcagctattacaacacttgttgtaacattactaattgcaataccatttttcaaattgccagttggtatcgcttctggtgcagtagtcgaggtttcttccaaggtaatcattccgattggctatatcgttatgatggcagtattgttatacaaaattactgttgaatctggacaatttttaacaattcaagatagtattacaaatatttcacaagaccaacgtattcaagttttacttattggatttgcattcaacgcatttttagaaggtgcagcaggatttggtgtaccaattgcaatttgtgcacttttattaacacaattaggatttaatccattaaaagctgcgatgttatgtttagtcgcaaatgcggcgtctggtgcttttggtgcgattggtatccctgtaggtgttgtagaaacgttgaaattacctggagatgtttcagtattaggtgtttctcaatcagcaactttaacattggcaatcataaatttcattattccattcttacttatctttattattgatggttttagaggtgttaaagaaacattaccagcaattttagtagtttcaatcacttatacacttactcaaggattattaactgtattcagtggacctgaattagcagatattattccaccgttattaacaatgttagcattagcagtattttctaaaaaattccaaccaaaacacatttatcgtgttaataaagatgaagaaattgaacctgcaaaagcacattctgcaaaagcagtattacatgcatggagcccattcattgtattaacagtcattgtaatgatttggagtgcgccattctttaaaaacttattcttaccaaatggtgctttatcatcattagtatttaaattcaacttacctggaacaatcagcgaagttacgcataaaccattagtattgactttaaatattattggacaaacaggtacagctattttattaactattattattacaattttaatgtctaaaaaggttaactttaaagatgcaggtagattattcggcgttacatttaaagagttgtggttaccagttcttacaatttgtttcatcttagcaatttctaaaatcacaacttatggtggtttaagtgcagcaatgggtcaaggtattgctaaagcaggtaatgtcttcccagttctatcaccaattttaggttggataggtgtgtttatgacaggatcagttgtaaataacaactcattatttgcaccaattcaagcttctgttgcacaacaaattggaacaagtggttcacttcttgtatctgctaatacagttggtggtgtagcggcaaaattgatttcaccacaatcaattgcaattgcaactgcagcagtaaaacaagttggtaaggaatcagaattattaaaaatgacattgaaatacagtgtatgtttactaatattcatctgtatttggactttcatcttgtcattatta |
205. | atgcttaaaaataaaatattaactacaactttatctgtgagcttacttgcccctcttgccaatccgttattagaaaatgctaaagctgctaacgatactgaagacatcggtaaaggaagcgatatagaaattatcaaaaggacagaagataaaacaagtaataaatggggcgtgactcaaaatattcaatttgattttgtaaaggataaaaaatataacaaagatgctttgatattaaagatgcaaggattcattagctctagaacaacatattacaactataaaaaaactaatcatgttaaagctatgcgatggccattccaatataatattggtttaaaaacaaatgataaatatgtttctttaattaattatttacctaaaaataaaattgaatctacaaacgtgagtcagatattaggatacaatatcggtggtaatttccaatcagccccatcactcggtggtaatggatcatttaactattctaaatcgattagctatacacaacaaaattatgtaagtgaagtagaacaacaaaactcaaaaagtgttttatggggcgtcaaagcgaattcattcgccactgaatcaggtcaaaaatcagcctttgatagcgatttatttgtaggctacaaacctcatagtaaagatcctagagattatttcgttccagacagtgagttaccacctcttgtacaaagtggatttaacccttcatttatcgccacagtatctcatgaaaaaggttcaatcgatacaagcgaatttgaaattacttacggaagaaacatggatgtcactcatgccattaaaagatcaacgcattatggcaacagttatttagacggacatagagtccataatgcatttgtaaatagaaactatactgtgaaatacgaggtcaattggaagactcatgaaatcaaggtgaaaggacagaat |
206. | atgaaaatgaataaattagtcaaatcatccgttgctacatctatggcattattattactttctggtactgctaatgctgaaggtaaaataacaccagtcagcgtaaaaaaagtcgatgacaaagttactttatacaaaacaacagccacagcagattctgataaatttaaaatttcacagattttaacatttaatttcatcaaagataaaagttatgataaagatactttagtacttaaagctactgggaatattaactcaggctttgtgaaacctaatcctaatgactatgacttttcaaaattatattggggagctaaatacaatgtatctataagctcacaatctaatgattcagtaaacgtcgttgattatgcaccaaaaaatcaaaatgaagagtttcaagttcaaaatactttaggctatacatttggtggtgacattagtatctctaatggtttatctggtggacttaatggaaatacagctttttctgaaacaattaattataaacaagaaagttacagaacaacattaagtcgcaacacaaattataaaaatgttggctggggagttgaagcacataaaattatgaataatggttggggaccttatggaagagatagcttccacccaacatatggtaatgaactcttcttagctggcagacaaagcagtgcatacgctggccaaaacttcatagcgcaacaccaaatgccattattatctagaagtaacttcaatccagaatttttaagcgtactatcacacagacaagatggcgctaaaaaatctaaaattacagtaacttatcaacgtgaaatggatttataccaaattcgttggaatggcttctactgggcaggcgcaaattataaaaactttaaaactagaacatttaaatcaacatatgaaattgattgggaaaatcacaaagtgaaattgttagatacaaaagaaactgaaaacaataaa |
207. | atgaatagagagatgttgtatttaaatagatcagatattgaacaagcgggaggtaatcattcacaagtttatgtggacgcattaacagaagcattaacagcccatgcgcacaatgattttgtacaaccgcttaagccgtatttaagacaggatcctgaaaatggacacatcgcagatcgaattattgcaatgccaagtcatatcggtggtgaacacgcaatttcaggtattaagtggataggtagtaagcacgacaatccatcgaaacgtaatatggagcgtgcaagtggcgtcattattttgaatgatccagaaacgaattatccaattgcagttatggaagcaagtttaattagtagtatgcgtactgcagcagtttcagtgattgcagcaaagcatttggctaaaaaaggatttaaagacttaacaatcattggatgcgggctaatcggagacaagcaattacaaagtatgttagagcaattcgatcatattgaacgcgtgtttgtttacgatcaattctctgaagcatgtgcacgctttgttgatagatggcaacaacagcgtccggaaattaattttattgcgacagaaaatgctaaagaagcagtatcaaatggtgaagtagtcattacatgtaccgtaacggatcaaccatacattgaatatgattggttacaaaagggtgcatttattagcaacatttctatcatggatgtgcataaagaagtctttattaaagctgacaaagtcgtagtagatgactggtcacaatgtaatcgagaaaagaaaactattaaccaattggtgttagaaggtaaattcagcaaagaagctcttcatgctgaactaggacaacttgtgacaggtgacataccaggacgtgaagacgatgatgagatcatattacttaatccgatgggtatggctatcgaagatatttcaagtgcttattttatttatcaacaggcacaacaacaaaatattgggacaacattgaacctatat |
208. | atgaaaaaaattatggttattttcggtacgagacccgaagcaataaaaatggcaccattagtaaaagaaattgatcataatgggaactttgaagcgaacattgtgattacagcacaacatagagatatgttagatagtgtgttaagtatatttgatattcaagctgatcatgatttaaatattatgcaagatcaacaaacattagcaggccttacggcgaatgcacttgctaaacttgatagcatcattaatgaggaacaaccggatatgattttagtacatggtgatactacaacgacttttgtaggaagtttggcagcattttatcatcaaattccggtcggacatgtagaagctggacttcgaacacatcagaaatactcaccatttcctgaagagttaaatcgagtcatggtaagtaatattgctgaattgaattttgcgccaacagtaattgcagctaaaaatttactttttgaaaacaaagacaaagagcgtatctttattactggaaatacagttattgacgcattgtcaacaacagttcaaaatgattttgtttcaacgattattaataaacataaaggcaagaaagttgttttactaacagcgcatcgtcgtgaaaatattggggaaccgatgcatcagatttttaaagcagtaagagatttggcagatgaatataaagatgttgtcttcatttatccaatgcatcgtaatccaaaggtaagagcgattgccgaaaaatatttatctgggagaaatcggattgaattaattgagccattagatgcgattgagttccataattttacaaatcaatcgtacctcgtgctgacagattctggtggtattcaagaggaggctcctacatttggaaaacctgtgttggtattaaggaatcatacagagcgtcccgaaggcgttgaggcgggaacatcgagagtaattggcacagattatgacaatattgttcgaaatgtgaaacaattgattgaggatgatgaagcgtatcaacgtatgagtcaagcgaataatccatatggtgatggacaagcatcacgacgtatttgtgaagcaatagaatattattttggattgcgcacagacaagccggatgaattcgtacctttacgtcacaaa |
209. | atgattatgggtaatttgagatttcaacaggaatattttcgtatatacaaaaataatacagaatcaacgacacaccgtaatgcgtattgggttaaactcgctaaaaatgttgaagctactaaaatgatgtatgcattatcgacaattgtgcaacaacatgcatctataagacatttttttgatgttactaccgatgacaatttaacaatgatacttcatgaatttctgccttttattgagataaaacaagttccatcttcttccgcaaactatgatttagaagctttttttaagcaagaattaagtacttaccattttaatgattcacctttattcaaagttaaattgtttcagttcgctgatgctgcatatatactattagattttcatgtgtccattttcgatgatagtcaaattgatatttttcttgatgatttatgcaatgcatatcgtggcaatactgttattaacaatactcgacagcatgcacatataaatagaaatgatgataaagacaatcaagatgcatcgcatatagcattagactcaaactattttcggttagagaataactctgacatccatattgatagttattttccaattaagcatccatttgaacaagctttatatcaaacgtatttgattgatgatatgacatcaatagatatggcatcgttggctgttagtgtgtatttagctaatcatataatgagtcaacaacatgatgtcacattaggtatacatgtaccatcacatttaccaaatgatttacacggaaatattgtgccgttaacgttaacaatcgatgcaaaagatgtatgtcaacgttttacaacagattttaataaatgtgtgttgcaaaatatgtcgcaattacagtgcgcgaagtcttcgctttcactagagactatttttcattgttatcatcatatgatgtcttgttgtaatgatgttattgaggatgtacatcaaatacatgatgcacatacatctttagcggatattgaaatttttccacatcaacacgggttcaaaattatatataacagtgcagcatatgatttgctctcaatcgagacgctgagtgacttagttcgaaatatttatttgcaaattactgaagaaaatggaaataaacgaacaactgtagatgaacttaatttgatgacagaacgtgatattcaattatatgacgatatcaatttaagtttgcctgagatagatgatgcgcaaacagttgttaccttatttgagcaacaagttgaagcaacgccgaatcatgtcgctgtgcaatttgacggagtgtttataacatatcaaacattgaatgcacgcgcgaatgatttagcacaccgtttgagaaaccagtatggtgttgaacctaatgatcgtgtcgctgtcatagctgaaaaaagtattgagatgataatagcgatgataggtgtgttgaaagctggtggggcttacgtgccaattgatccgaactatccaagtgatcgtcaggagtacattttaaaagatgtaacgcctaaagttgtaataacgtaccaagctttatatgaaaatggtaaacaaaatattaatcacattgatttgaataagatagcgtggaaaaatattgataatctttctaaatgtaacacgttagaagatcatgcttatgttatttacacgtcggggacaactggtaaccctaaagggacactaattccgcaccgaggtattgttcgcttggtccatcaaaatcattatgtaccattaaatgaagagacgacgattttgttatcaggaactatagcctttgatgctgcaacatttgaaatatatggtgcattgctcaatggtggaaagctgattgttgctaaaaaagaacaattattaaatccaatagcggtagaacaattaatcaatgaaaatgacgttaatactatgtggttaacctcctcattatttaatcagattgctagtgaacgaatagaagtattggtatcgttaaagtatttattaattggtggagaagtattgaatgctaagtgggtggatttgcttaatcaaaaaccgaagcatcctcaaattattaatggttatggaccaactgaaaatacaacatttacaacgacgtataatatacctaacaaagttccaaatcgtattcctattggtaaaccgattctgggtactcatgtttatatcatgcaaggcgagcgtcggtgtggcgttggtattcctggagaattatgtacaagtggctttgggttagctgcaggttatttaaatcagccagaattgacagcagataaatttatcaaagattcaaatataaatcagctgatgtatagaagtggtgatatcgttcgtttgttacccgatggcaacatagattatttatatcgaaaggacaaacaagttaagattcgagggtttaggattgagttgtcagaggttgagcatgcgctcgagcgtatacaaggtattaataaagcagttgttattgttcaaaatcatgatcaagatcagtatatcgttgcttattatgaagcgatgcatacattatcacataataagattaaatcacaattacgtatgaccttaccggagtacatgataccagttaatttcatgcatattgagcaaattcctattactattaatgggaaattagataagaaggcattgcctatcatggactatgtcgatacggatgcctatgtagcaccgagtacagataccgaacacttgctatgccaaatttttgcagatattttacatgtgaatcaagtaggtattcatgataatttctttgaattaggtggccattcattaaaagcaacgttagtggtgaatcggatagaggcatctactgggaaacgattacaaattggtgatttattacaaaagccaactgtatttgaactagcacaagcgattgctaaggttcaagaacaaaactatgaagtgattccagaaactatagttaaagatgattatgtgctgagctctgcacaaaagcgtatgtatttattatggaaatcaaaccataaagatacggtgtataacgtaccttttttatggcggttatcatcagaacttaatgtagctcaattgcgacaagcagtgcagcgtttgatagcgcgacatgagattttacgaacacaatatattgttgtagatgatgaggttcgacaacgtattgtggcagatgttgcagttgactttgaagaagttaacacgcattttacggatgaacaagaaatcatgcgccaatttgtagcaccttttaatttggaaaagccaagtcaaattagagtgagatacattagaagtcccttacatgcatacctctttatagatacgcatcatatcattaatgacggtatgagtaatatacaattaatgaatgatcttaacgcactttatcaacataaattattgttaccacttaaattgcaatataaagactatagtgagtggatgtcgcatcgtgatatgacgaaacatagacaatattggttatctcaattcaaagatgaagtacctattttaagcttaccgacagactatgttagaccaaatattaaaacgacaaatggagcaatgatgtcatttacaatgaatcaacaaatgagacagctacttcaaaagtatgtagaaaagcatcaaattactgattttatgttctttatgagtgtggtcatgacgttgttaagtagatatgctcgaaaagatgatgttgttgtcggtagtgtgatgagtgcgcgtatgcataaaggcacggagcaaatgctaggcatgtttgctaatacgttggtatatagagggcaaccgtcacctgataaaatgtggacacagtttttacaagaggttaaggaaatgagtttggaggcatacgagcatcaagaatacccattcgaatgtttagtaaatgacttagatcaatcacatgatgcctcacggaatccattatttgatgtcatgttagtactacaaaacaatgaaacgaatcatgctcattttgggcatagtaaattaacacacattcaacccaaatcagtgacggcgaaatttgatttatctttcatcattgaagaagatcgcgatgactatacaatcaatatcgaagtataataccatttatatcactcagaaacagttcgtcacatgggtaatcaatgtatgattatgattgattatattttgaagcatcaagatacactacaaatttgtgatataccaaacggcacggaggaacttctaaattgggtcaatacgcatgttaacgatcgaatgcttaatgtcccgggaaataaatctatcataagttactttaatgaagttgtctcacgacaaggtaatcatgttgcgctagtcatgaatgatttgacaatgacgtatgaaacattacgcaactatgtggatgccattgcgcacatgctcctatcaaatggtgtgggcaatggtcaacgggttgccttgtttacagaacgtagttttgaaatgattgcggcgatgttggcgacagttaaagtaggtgcatcttatatacctatcgatattgattttccgaataaacgacaaggtgcaattttggaggatgctaaagtaactgcagtcatgtcttacggcgttgaaattgaaacgacattaccagtcattcaattggaaaatgctaaaggctttgttgaatcaaaggaaaatgaacaatatgatgatttacatggcaatcaacttgaaaacacagcgatgttagataatgagatgtatgctatttacacatctggtacgaccgggatgcctaaaggggttgccatacgacaacgaaatttgttgaatttagtgcatgcatggtcaactgaattgcaattaggcgacaatgaagtatttttgcaacatgcaaatattgtttttgatgcatcagttatggagatttattgttgtttgttaaatggtcatacgcttgtgattccagatagagaggaacgtgttaatccagaacagttacaacaactcattaataagcatcgtgtgacggttgcgtcgattccgttacagatgtgtagtgttatggaagacttttatattgaaaagttgattacaggcggggcaactagtacggcatcctttgttaaatatattgagaagcattgtggcacgtatttcaatgcctatggaccatctgagtcaacagtcatcacatctgattggtcacatcattgtggtgatttgatacctgagacgattccaattggcaaacccttatctaacatacaagtgtatattatgtcagatggtttgttatgcggtattggtatgccaggcgagttgtgtattgcaggtgatagtttagcgataggatatattaatcgtccagaattaatggctgataaatggcaaaataatccatttggtaaaggaaagttgtatcatagtggtgatttagcacgttatacatctgatggtcaaattgaatttttaggaagaatagataaacaagtgaaagttaacgggtaccgtattgaacttgatgaaattgaaaatgcaatattagctattcgtggtatatctgattgtgttgtaaca |
gtaagtcactttgatacgcatgatatattgaatgcttattatgtcggagagcaacaagtggaacaggatttgaagcaatatttaaatgatcagctgcctaagtatatgattcctaagactataacgcatatcgattgtatgccattaaccacgaatgacaaggtggatactacgcgtttgccaaatccatcacctatacaacagtctaataaagtgtatagcgaaccctctaatgaaattgagcagacatttgttgatgtatttggagaggtattgaaacaaaatgatgtcggtgttgacgatgatttctttgaacttggtggtaactcattagaggcgatgttagttgtctcgcatttaaaacgatttggccatcatatttcaatgcagacattataccaatataaaaccgtgcgacagattgttaattatatgtaccaaaatcaacaatcattagttgcattaccggataatctttcggaattacaaaagattgttatgtctcgttataacttgggtattttagaggatagtctaagtcatcgacctctaggaaatacactattgactggcgcgacaggttttttaggtgcttatctgattgaagtactacaaggatacagtcatcgcatttattgtttcatacgtgctgataatgaggaaatagcatggtataagttgatgacgaatttaaatgattatttttcagaagagacggttgaaataatgttatcaaacattgaagtcattgttggtgatttcgagtgtatggatgatgttgttttaccagaaaacatggatacgattattcatgcaggtgctcgtacagatcactttggtgatgatgatgaatttgaaaaagtaaatgttcaaggtactgttgatgtcatacgtttggcacaacaacatcatgcaaggttaatatatgtgtctacgataagtgtgggaacttattttgatatagacacagaagatgtgacattttcagaagcggatgtctataaagggcaactactaacatcaccatatacacggagcaaattttatagtgaattaaaagtattagaagctgtaaataatggcttagatggtcggattgtacgtgttggtaatttgacgaatccttacaatggaagatggcatatgagaaatataaagactaaccgtttttcaatggtaatgaatgatttgttacaactggattgtatcggggttagcatggctgaaatgcctgtagatttttcttttgtggatacgactgcaagacaaattgtcgcattagcacaggtcaacacaccacaaatcatttaccatgtgctatcacctaataaaatgccggtgaaatctttgttagaatgcgttaagcgcaaagaaattgaactcgtcagcgatgaatcatttaatgaaattttacagaaacaagacatgtacgaaacgattggattaactagtgttgaccgtgaacaacaactagcaatgatagatacaacattaacattaaaaataatgaatcacatcagtgaaaaatggccaacgataactaacaattggctgtatcattgggcacaatatatcaaaacaatattcaataag |
210. | atgaccaaagaacaacaacttgcagaacgaattattgctgcagtaggtggtatggataatatagatagtgtcatgaactgtatgacacgtgtgcgtattaaagtattagatgagaataaagtagatgaccaagaactaaggcatattgatggtgtcatgggtgttatacacgatgaacgcattcaagttgtggttggacctggtacagtcaataaagtggctaatcatatggcggaattaagtggtgttaaactaggtgacccaataccacaccatcacaatgatagtgaaaaaatggactataaatcatatgcagctgataaagcaaaggcgaataaggaagcgcataaagcaaaacaaaagaatggtaagttgaataaagtattgaaatcaattgccaatatctttataccgttgattcctgcatttattggagctggattaattggtggtattgcagcagtactgagtaacttaatggtggcaggctatatttcaggtgcttggattacgcaacttataacagtatttaatgtcattaaagacggtatgttagcatacttagctattttcactggtattaatgcggctaaagaatttggtgcgacaccaggacttggtggcgtgattggtggtacaacgttattaacgggtattgctggtaaaaatattttaatgaatgtcttcactggagaaccattgcaacctggacaaggtgggattattggcgttatttttgccgtttggattttaagtattgtcgaaaagagattacataaaattgtgccaaatgcgattgatattattgtaacgccgactattgcattgttgattgtaggactattaactatctttatctttatgccattagcaggttttgtttcagacagtttagtttcagtagttaacggaattattagtattggtggcgtatttagtggatttatcattggtgcaagcttcctaccgttagttatgttagggcttcatcatatttttacgccaattcatatagaaatgattaaccaatcaggtgctacttacttattgccaattgcagcgatggctggtgctggacaagtaggtgccgcattagcactttgggtaagatgtaaacgcaacacaacattacgtaatactttaaaaggtgcattgccagttggtttcctaggtatcggagaaccattaatctatggtgtgactttgccattaggtcgacctttcttaactgcttgtattggtggtggtattggtggcgctgtaataggtggaattggacatattggtgccaaagcaataggcccaagtggtgtgtcactattaccattaatctcagataatatgtatttaggttatattgcaggattacttgctgcgtatgctggtggattcgtttgtacatatttatttggaacgacaaaggcgatgcgacagacagatttgttgggtgat |
211. | atgtctaaaattttaaaatgtatcacgttagccgtggtaatgttattaatcgtaactgcatgtggccctaatcgttcgaaagaagatattgataaagcattgaataaagataattctaaagacaagcctaaccaacttacgatgtgggtggatggcgacaagcaaatggcgttttataaaaaaattacggatcaatatactaaaaaaactggcatcaaagtaaagcttgtaaatattggtcaaaatgatcaactagaaaatatttcgctagacgctcctgcaggaaaaggtccagatatctttttcttagcacatgataatactggaagtgcctatctacaaggcttagctgctgaaatcaaattatcaaaagatgagttgaaaggtttcaataagcaagcacttaaagcgatgaattatgacaataagcaactagcattgccagctatcgttgaaacaaccgcacttttttataataaaaaattagtgaaaaatgcaccgcaaacgttagaagaagttgaagctaatgctgccaaactaactgatagtaaaaagaaacaatacggtatgttatttgatgctaaaaatttctattttaattatccgtttttattcggcaatgatgattatattttcaagaaaaatggcagtgaatatgatattcatcagctaggactaaattcaaaacatgtcgtcaagaatgctgaacgattacaaaaatggtacgacaaagggtatcttcctaaggcagcaacacatgatgtcatgattggtctttttaaagaaggaaaagtaggacaatttgtcactggaccgtggaacattaatgaatatcaagaaacgtttggtaaagatttaggagtaacaacattacctacagatggtggcaaacctatgaaaccatttctaggtgtacgtggttggtatttatctgaatatagtaaacataagtattgggctaaagatttaatgctgtatatcactagtaaagatacattacaaaaatatacagatgaaatgagcgaaattactggacgtgttgacgtgaaatcatctaatccaaatttaaaagtgtttgaaaagcaagcacgtcatgctgaaccgatgcctaatattcctgaaatgcgacaagtttgggaaccgatgggcaatgcaagcatatttatttcaaatggtaagaatcctaaacaagcgttagatgaggcgacgaatgatataacgcaaaatattaagattcttcatccatcacaaaatgataagaaaggagat |
212. | gtgaaagcattgaaattatatggcgtggaagatttacggtatgaggataatgaaaagccagtcattgaaagtgcgaatgacgttattattaaagtacgagcgactggcatatgtggttcagacacgtcacgatacaaaaaaatggggccatacattaaaggtatgccatttggtcatgaattttcaggtgtagtagatgccattggaagtgatgttacgcatgttaatgtgggcgacaaagtgacaggttgcccagcaataccttgttatcaatgcgagtattgtttaaaaggtgaatatgcacgatgtgaaaagttattcgtcattggctcatatgaacctggatcgttcgcggaatatgtcaaattgccagcgcaaaatgttttaaaggttccagacaatgttgattacattgaagcagcaatggttgagccatcagccgttgttgcgcatgggttttataaatcgaatatacaacctggtatgactgttgcagtaatggggtgtggcagtataggtttgttagctattcaatgggcacgaatatttggtgctgcacatatcatcgctatagatatagatgcgcataaactagatattgcaacatcattgggcgcacatcaaacaatcaattcaaaagaagaaaatcttgagaaattcatcgaaaatcattacgccaatcaaatcgatttagctatagaatcatcaggtgctaaagttacgattggtcaaatattgacgctacctaaaaaaggtggcgaggtggtattactcggaataccatatgatgatattgagattgatcgcgttcattttgaaaaaattctgcgtaacgagttgacagtatgtggctcttggaactgtttgtccagtaattttccgggcaaagagtggacggcaaccttacattatatgaagacgaaagatattaatgtaaagcctattatttctcattttttaccgttagaaaaaggcccggagacatttgataaattagttaacaagaaagaacgatttgataaagtcatgtttacgatttat |
213. | atgcaagcattacaaacatttaattttaaagagctaccagtaagaacagtagaaattgaaaacgaaccttattttgtaggaaaagatattgctgagattttaggatatgcaagatcagacaatgccattagaaatcatgttgatagcgaggacaagctgacgcaccaatttagtgcatcaggtcaaaacagaaatatgatcattatcaacgaatcaggattatacagtctaatcttcgatgcttctaaacaaagcaaaaacgaaaaaatcagagaaaccgctcggaaattcaaacgatgggtaacatcagatgtcctaccagctattcgcaaacacggtatatacgcaacagacaatgtaattgaacaaacattaaaagatccagactacatcattacagtgttgactgagtataagaaagaaaaagagcaaaacttacttttacaacaagaaatcggagaactaaaacccaaagcagactatgtagatgaaatcttaaagtcaactggcacattagccacaactcaaatcgcggcagactacggtatatcagcacaaaagttaaacaaactactacacgaagctagactacaacgaaaagtaaataaacagtgggtgctttactcagaacacatgggcaagagttacacagaatcagacactatagcaattgtacgctctgacggtagagaagacacagttttacaaactagatggacacaaaaaggcagattgaaaatacatgaaatcatgactgaattcggttatgaagctaatttagggggagcg |
214. | atgaaattaaaatcattagcagtgttatcaatgtcagcggtggtgcttactgcatgtggcaatgatactccaaaagatgaaacaaaatcaacagagtcaaatactaatcaagacactaatacaacaaaagatgttattgctttaaaagatgttaaaacaagcccagaagatgctgtgaaaaaagctgaagaaacttacaaaggccaaaagttgaaaggaatttcatttgaaaattctaatggtgaatgggcttataaagtgacgcaacaaaaatctggtgaagagtcagaagtacttgttgctgataaaaataaaaaagtgattaacaaaaagactgaaaaagaagatacaatgaatgaaaatgataactttaaatatagcgatgctatagattacaaaaaagccattaaagaaggacaaaaagaatttgatggtgatattaaagaatggtcacttgaaaaagatgatggcaaacttgtttacaatatcgatttgaaaaaaggtaataaaaaacaagaagttactgttgatgctaagaacggtaaagtattaaagagtgagcaagatcac |
215. | atgaaaatgaaaaatattgcaaaaataagtttgttattaggaatattagcaacaggtgtaaacactacaacggaaaaaccagttcatgccgaaaagaaaccgattgtaataagtgaaaatagcaaaaaattaaaagcttattataatcaacctagtattgaatataaaaatgtgacaggttatatcagtttcattcaaccaagtattaaatttatgaatatcatagatggtaattctgttaataatattgctttaattggcaaagataagcaacattatcatacgggtgtacatcgtaatcttaatatattttacgttaatgaggataagagatttgaaggtgcaaagtactctattgggggtatcacgagtgcaaacgataaagctgtcgacctaatagcagaagcaagagttattaaagaagatcatactggtgaatatgattatgactttttcccatttaaaatagataaagaagcgatgtcattgaaagagattgattttaaattaagaaaataccttattgataattatggtctttacggtgaaatgagtacaggaaaaattacagtcaaaaagaaatactatggaaagtatacatttgaattggataaaaagttacaagaagaccgtatgtccgatgttatcaatgtcacagatattgatagaattgaaatcaaagttataaaagca |
216. | mrktkivctigpaseseemieklinagmnvarlnfshgsheehkgridtirkvakrldkivailldtkgpeirthnmkdgiielergnevivsmnevegtpekfsvtyenlindvgvgsyillddglielqvkdidhakkevkcdilnsgelknkkgvnlpgvrvslpgitekdaedirfgikenvdgiaasfvrrpsdvleireileeqkanisvfpkienpegidniaeilevsdglmvargdmgveippekvpmvqkdlirqcnklgkpvitatgmldsmqrnpratraeasdvanaiydgtdavmlsgetaaglypeeavktmrniavsaeaaqdykkllsdrtklvetslvnaigisvahtalnlnvkaivaatesgstartiskyrphsdiiavtpseetarqcsivwgvqpvvkkgrkstdallnnavatavetgrvsngdliiitagvptgetgttnmmkihlvgdeiangqgigrgsvvgttlvaetvkdlegkdlsdkvivtnsidetfvpyvekalgliteengitspsaivglekgiptvvgvekavknisnnmlvtidaaggkifegyanvl |
217. | mqfdnidsalmalkngepiivvddenrenegdlvavtewmndntinfmakearglicapvskdiaqrldlvpmvddnsdifgtqftvsidhvdtttgisayertltakklidpsseakdfnrpghlfplvaqdkgvlarnghteaavdlakltgakpagviceimnddgtmakgqdlqkfkekhqlkmitiddlieyrkklepeiefkakvkmptdfgtfdmygfkatytdeeivvltkgairqhenvrlhsacltgdifhsqrcdcgeqlesamkyinehggmiiylpqegrgigllnklrayelieqgydtvtanlalgfdedlrdyhiaaqilkyfniehinllsnnpskfeglkqygidiaerievivpetvhnhdymetkkikmghli |
218. | mkmkklvkssvassiallllsntvdaaqhitpvsekkvddkitlykttatsdndklnisqiltfnfikdksydkdtlvlkaagninsgykkpapkdynysqfywggkynvsvssesndavnvvdyapknqneefqvqqtlgysyggdinisnglsgglngsksfsetinykqesyrttidrktnhksigwgveahkimnngwgpygrdsydptygnelflggrqsssnagqnflpthqmpllargnfnpefisvlshkqndtkkskikvtyqremdrytnqwnrlhwvgnnyknqntvtftstyevdwqnhtvkligtdsketnpgv |
219. | mkkkallplflgimvflagcdyskpekrsgffyntfvdpmknvldwlgnnllndnyglaiiilvlviriillpfmlsnyknshmmrqkmkvakpevekiqekvkrartqeekmaanqelmqvykkydmnpiksmlgclpmliqlpiimglyfvlkdqlvdglfkyphflwfdlgrpdiwitiiagvlyfiqayvssktmpdeqrqmgymmmvispimifwislssasalglywsvsaaflvvqthfaniyyekvakkevqpfieayerehnggsnkkgkntqvvskkkkk |
220. | mnlfrqqkfsirkfnvgifsaliatvtfistnpttasaaeqnqpaqnqpaqpadantqpnanagaqanptaqpaapanqgqpavqpanqggqanpaggaaqpntqpagqgnqadpnnaaqaqpgnqatpanqagqgnnqatpnnnatpanqtqpanqpaaaqpaapvaanaqtqdpnasntgegsinttltfddpaistdenrqdptvtvtdkvngyslinngkigfvnselrrsdmfdknnpqnyqakgnvaalgrvnandstdhgnfngisktvnvkpdseliinfttmqtnskqgatnlvikdakkntelatvnvaktgtahlfkvptdadrldlqfipdntavadasrittnkdgykyysfidnvglfsgshlyvknrdlapkatnnkeytinteignngnfgaslkadqfkyevtlpqgvtyvnnsltttfpngnedstvlknmtvnydqnankvtftsqgvttargthtkevlfpdkslklsykvnvanidtpknidfnekltyrtasdvvinnaqpevtltadpfsvavemnkdalqqqvnsqvdnshyttasiaeynklkqqadtilnedanhvktanrasqadidglvtklqaalidnqaaiaeldtkaqekvtaaqqskkvtqdevaalvtkinndknnaiaeinkqttaqgvttekdngiavleqdvitptvkpqakqdiiqavttrkqqikksnaslqdekdvandkigkietkaikdidaattnaqveaiktkaindinqttpattakaaaleefdevvqaqidqaplnpdttneevaeaierinaakvsgvkaieatttaqdlervkneeiskienitdstqtkmdaynevkqaatarkaqnatvsnatneevaeadaavdaaqkqglhdiqvvkskqevadtkskvldkinaiqtqakvkpaadtevenayntrkqeiqnsnastteekqaayteldtkkqeartnldaantnsdvttakdnsiaainqvqaattkksdakaeiaqkaserktaieamndstteeqqaakdkvdqavvtanadidnaaanndvdnakttneatiaaitpdanvkpaakqaiadkvqaqetaidgnngstteekaaakqqvqtekttadaaidaahtnaeveaakkaaiakieaiqpatttkdnakeaiatkanerktaiaqtqditaeeiaaanadvdnavtqansnieaansqndvdqakttgensidqvtptvnkkatarneitailnnklqeiqatpdatdeekqaadaeantengkanqaisaattnaqvdeakanaeaainavtpkvvkkqaakdeidqlqatqtnvinndqnatteekeaaiqqlatavtdaknnitaatddngvdqakdagknsiqstqpatavksnakndvdqavttqnqaidnttgatteeknaakdlvlkakekayqdilnaqttndvtqikdqavadiqgitadttikdvakdelatkaneqkaliaqtadatteekeqanqqvdaqltqgnqnienaqsiddvntakdnaiqaidpiqastdvktnaraelltemqnkiteilnnnettneekgmdigpvraayeeglnninaatttgdvttakdtavqkvqqlhanpvkkpagkkeldqaaadkktqieqtpnasqqeindakqevdtelnqaktnvdqsstneyvdnavkegkakinavktfseykkdalakiedaynakvneadnsnastsseiaeakqklaelkqtadqnvnqatskddievqihndldnindytiptgkkesattdlyayadgkknnisadtnatqdekqqaikqvdqnvqtalesinngvdngdvddaltqgkaaidaiqvdatvkpkanqaievkaedtkesidqsdqltaeektealamikqitdqakqgitdatttaevekakaqgleafdniqidstekqkaieeletaldqieagvnvnadatteekeaftnaledilskatedisdqttnaeiatvknsaleqlkaqrinpevkknaleairevvnkqieiiknadadasakeiartdlgryfdrfadkldktqtnaevaelqnvtipaieaivpqndpdandtnngidnndatansnanatpentgqpnvsettangkadaspttpnnsdaatgettatsatddandkpqannnssvdastnsptmdndvtskpevestnngttdkpvtetdnatpaesttnnnstttatnenaptgstatapttasteaassadskdnasvndskqnaevnnsaesqstndkvaqpksenkakaekdgsdstnqsmvesttetlpsaditepnvpsntskdkeesttnqtdagqlksetnvasneadkspskadtevsnkpstsasseakekmtstnlsqkddtatadtndtqksvgsaannkatqndganaspatvsngsnsanqdmlnvtntddhqaktksaqqgkvnkakqqaktlpdtgmshnddlpyaelalgagmaflirrftkkdqqtee |
221. | mklksfvtatlalgllstvgaalpsheasadsnngykemtvdgyhtvpytisvdgitalhrtvfifpenknvlyqeidskvknelasqrgvttekinnaqtatytltlndgnkkvvnlkknddaknsidpstikqiqivvk |
222. | maikkykpitngrrnmtsldfaeitkttpeksllkplpkkagrnnqgkltvrhhggghkrqyrvidfkrnkdginakvdsiqydpnrsanialvvyadgekryiiapkglevgqivesgaeadikvgnalplqniqvgtvvhnielkpgkggqiarsagasaqvigkegkyvlirlrsgevrmilstcratigqvgnlqhelvnvgkagrsrwkgirptvrgsvmnpndhphgggegrapigrpspmspwgkptlgkktrrgkkssdklivrgrkkk |
223. | mlvntfnpfdnlllssliaaipivlfllcltvfkmkgiyaaittlvvtlliaipffklpvgiasgavvegffqgiipigyivmmavllykitvesgqfltiqdsitnisqdqriqvlligfafnaflegaagfgvpiaicallltqlgfnplkaamlclvanaasgafgaigipvgvvetlklpgdvsvlgvsqsatltlaiinfiipfllifiidgfrgvketlpailvvsitytltgglltvfsgpeladiipplltmlalavfskkfqpkhiyrvnkdeeiepakahsakavlhawspfivltvivmiwsapffknlflpngalsslvfkfnlpgtisevthkplvltlniigqtgtailltiiitilmskkvnfkdagrlfgvtfkelwlpvlticfilaiskittygglsaamgqgiakagnvfpvlspilgwigvfmtgsvvnnnslfapiqasvaqqigtsgsllvsantvggvaaklispqsiaiataavkqvgkesellkmtlkysvcllificiwtfilsll |
224. | mlknkiltttlsvsllaplanpllenakaandtedigkgsdieiikrtedktsnkwgvtqniqfdfvkdkkynkdalilkmqgfissrttyynykktnhvkamrwpfqyniglktndkyvslinylpknkiestnvsqilgyniggnfqsapslggngsfnysksisytqqnyvseveqqnsksvlwgvkansfatesgqksafdsdlfvgykphskdprdyfvpdselpplvqsgfnpsfiatvshekgssdtsefeitygrnmdvthaikrsthygnsyldghrvhnafvnrnytvkyevnwktheikvkgqn |
225. | mkmnklvkssvatsmallllsgtanaegkitpvsvkkvddkvtlykttatadsdkfkisqiltfnfikdksydkdtlvlkatgninsgfvkpnpndydfsklywgakynvsissqsndsvnvvdyapknqneefqvqntlgytfggdisisnglsgglngntafsetinykqesyrttlsrntnyknvgwgveahkimnngwgpygrdsfhptygnelflagrqssayagqnfiaqhqmpllsrsnfnpeflsvlshrqdgakkskitvtyqremdlyqirwngfywaganyknfktrtfkstyeidwenhkvklldtketennk |
226. | mnremlylnrsdieqaggnhsqvyvdaltealtahahndfvqplkpylrqdpenghiadriiampshiggehaisgikwigskhdnpskrnmerasgviilndpetnypiavmeaslissmrtaavsviaakhlakkgfkdltiigcgligdkqlqsmleqfdhiervfvydqfseacarfvdrwqqqrpeinfiatenakeavsngevvitctvtdqpyieydwlqkgafisnisimdvhkevfikadkvvvddwsqcnrekktinqlvlegkfskealhaelgqlvtgdipgredddeiillnpmgmaiedissayfiyqqaqqqnigttlnly |
227. | mkkimvifgtrpeaikmaplvkeidhngnfeanivitaqhrdmldsvlsifdiqadhdlnimqdqqtlagltanalakldsiineeqpdmilvhgdttttfvgslaafyhqipvghveaglrthqkyspfpeelnrvmvsniaelnfaptviaaknllfenkdkerifitgntvidalsttvqndfvstiinkhkgkkvvlltahrrenigepmhqifkavrdladeykdvvfiypmhrnpkvraiaekylsgrnrieliepldaiefhnftnqsylvltdsggiqeeaptfgkpvlvlrnhterpegveagtsrvigtdydnivrnvkqlieddeayqrmsqannpygdgqasrriceaieyyfglrtdkpdefvplrhk |
228. | mimgnlrfqqeyfriyknntestthrnauwvklaknveatkmmyalstivqqhasirhffdvttddnltmilheflpfieikqvpsssanydleaffkqelstyhfndsplfkvklfqfadaayilldfhvsifddsqidiflddlcnayrgntvinntrqhahinrnddkdnqdashialdsnyfrlennsdihidsyfpikhpfeqalyptyliddmtsidmaslavsvylanhimsqqhdvtlgihvpshlpndlhgnivpltltidakdvcqrfttdfnkcvlqnmsqlqcaksslsletifhcyhhmmsccndviedvhqihdahtsladieifphqhgfkiiynsaaydllsietlsdlvrniylqiteengnkrttvdelnlmterdiqlyddinlslpeiddaqtvvtlfeqqveatpnhvavqfdgvfityqtlnarandlahrlrnqygvepndrvaviaeksiemiiamigvlkaggayvpidpnypsdrqeyilkdvtpkvvityqalyengkqninhidlnkiawknidnlskcntledhayviytsgttgnpkgtliphrgivrlvhqnhyvplneettillsgtiafdaatfeiygallnggklivakkeqllnpiaveqlinendvntmwltsslfnqiaserievlvslkylliggevlnakwvdllnqkpkhpqiingygptenttftttynipnkvpnripigkpilgthvyimqgerrcgvgipgelctsgfglaagylnqpeltadkfikdsninqlmyrsgdivrllpdgnidylyrkdkqvkirgfrielsevehaleriqginkavvivqnhdqdqyivayyeamhtlshnkiksqlrmtlpeymipvnfmhieqipitingkldkkalpimdyvdtdayvapstdtehllcqifadilhvnqvgihdnffelgghslkatlvvnrieastgkrlqigdllqkptvfelaqaiakvqeqnyevipetivkddyvlssaqkrmyllwksnhkdtvynvpflwrlsselnvaqlrqavqrliarheilrtqyivvddevrqrivadvavdfeevnthftdeqeimrqfvapfnlekpsqirvryirsplhaylfidthhiindgmsniqlmndlnalyqnklllplklqykdysewmshrdmtkhrqywlsqfkdevpilslptdyvrpnikttngammsftmnqqmrqllqkyvekhqitdfmffmsvvmtllsryarkddvvvgsvmsarmhkgteqmlgmfantlvyrgqpspdkmwtqflqevkemsleayehqeypfeclvndldqshdasrnplfdvmlvlqnnetnhahfghsklthiqpksvtakfdlsfiieedrddytinieyntdlyhsetvrhmgnqcmimidyilkbqdtlqicdipngteellnwvnthvndrmlnvpgnksiisyfnevvsrqgnhvalvmndltmtyetlrnyvdaiahmllsngvgngqrvalftersfemiaamlatvkvgasyipididfpnkrqgailedakvtavmsygveiettlpvlqlenakgfveskeneqyddlhgnqlentamldnemyaiytsgttgmpkgvairqrnllnlvhawstelqlgdnevflqhanivfdasvmeiyccllnghtlvipdreervnpeqlqqlinkhrvtvasiplqmcsvmedfyieklitggatstasfvkyiekhcgtyfnaygpsestvitsywshhcgdlipetipigkplsniqvyimsdgllcgigmpgelciagdslaigyinrpelmadkwqnnpfgkgklyhsgdlarytsdgqieflgridkqvkvngyrieldeienailairgisdcvvtvshfdthdilnayyvgeqqveqdlkqylndqlpkymipktithidcmplttndkvdttrlpnpspiqqsnkvysepsneieqtfvdvfgevlkqndvgvdddffelggnsleamlvvshlkrfghhismqtlyqyktvrqivnymyqnqqslvalpdnlselqkivmsrynlgiledslshrplgntlltgatgflgaylievlqgyshriycfiradneeiawyklmtnlndyfseetveimlsnievivgdfecmddvvlpenmdtiihagartdhfgdddefekvnvqgtvdvirlaqqhharliyvstisvgtyfdidtedvtfseadvykgqlltspytrskfyselkvleavnngldgrivrvgnltnpyngrwhmrniktnrfsmvmndllqldcigvsmaempvdfsfvdttarqivalaqvntpqiiyhvlspnkmpvksllecvkrkeielvsdesfneilqkqdmyetigltsvdreqqlamidttltlkimnhisekwptitnnwlyhwaqyiktifnk |
229. | mtkeqqlaeriiaavggmdnidsvmncmtrvrikvldenkvddqelrhidgvmgvihderiqvvvgpgtvnkvanhmaelsgvklgdpiphhhndsekmdyksyaadkakankeahkakqkngklnkvlksianifiplipafigagliggiaavlsnlmvagyisgawitqlitvfnvikdgmlaylaiftginaakefgatpglggviggttlltgiagknilmmvftgeplqpggggiigvifavwilsivekrlhkivpnaidiivtptiallivglltififmplagfvsdslvsvvngiisiggvfsgfiigasflplvmlglhhiftpihieminqsgatyllpiaamagagqvgaalalwvrckrnttlrntlkgalpvgflgigepliygvtlplgrpfltacigggiggaviggighigakaigpsgvsllplisdnmylgyiagllaayaggfvctylfgttkamrqtdllgd |
230. | mskilkcitlavvmllivtacgpnrskedidkalnkdnskdkpnqltmwvdgdkqmafykkitdqytkktgikvklvnigqndqlenisldapagkgpdifflahdntgsaylqglaaeiklskdelkgfnkqalkamnydndqlalpaivattalfynkklvknapqtleeveanaakltdskkkqygmlfdaknfyfnypflfgnddyifkkngseydihqlglnskhvvknaerlqkwydkgylpkaathdvmiglfkegkvgqfvtgpwnineyqetfgkdlgvttlptdggdpmkpflgvrgwylseyskhkywakdlmlyitskdtlqkytdemseitgrvdvkssnpnlkvfekqarhaepmpnipemrgvwepmgnasifisngknpkqaldeatnditqnikilhpsqndkkgd |
231. | vkalklygvedlryednekpviesandviikvratgicgsdtsrykkmgpyikgmpfghefsgvvdaigsdvthvnvgdkvtgcpaipcyqceyclkgeyarceklfvigsyepgsfaeyvklpaqnvlkvpdnvdyieaamvepsavvahgfyksniqpgmtvavmgcgsigllaiqwarifgaahiiaididahkldiatslgahqtinskeenlekfienhyanqidlaiessgakvtigqiltlpkkggevvllgipyddieidrvhfekilrneltvcgswnclssnfpgkewtatlhymktkdinvkpiishflplekgpetfdklvnkkerfdkvmftiy |
232. | mqalgtfnfkelpvrtveienepyfvgkdiaeilgyarsdnairnhvdsedklthqfsasgqnrnmiiinesglyslifdaskqsknekiretarkfkrwvtsdvlpairkhgiyatdnvieqtlkdpdyiitvlteykkekeqnlllqqeigelkpkadyvdeilkstgtlattgiaadygisaqklnkllhearlqrkvnkqwvlysehmgksytesdtiaivrsdgredtvlqtrwtqjgrlkiheimtefgyeanlgga |
233. | mklkslavlsmsavvltacgndtpkdetkstesntnqdtnttkdvialkdvktspedavkkaeetykgqklkgisrensngewaykvtqqksgeesevlvadknkkvinkktekedtmaendnfkysdaidykkaikegqkefdgdikewslekddgklvynidlkkgnkkqevtvdakngkvlkseqdh |
234. | mkmkniakislllgilatgvntttekpvhaekkpivisenskklkayynqpsieyknvtgyisfiqpsikfmniidgnsvnnialigkdkqhyhtgvhrnlnifyvnedkrfegakysiggitsandkavdliaearvikedhtgeydydffpfkidkeamslkeidfklrkylidnyglygemstgkitvkkkyygkytfeldkklqedrmsdvinvtdidrieikvika |
235. | TtgaaaaatattttaaaagtttttaatacaacgattttagcgttaattatcatcatcgcgAcattcagtaattctgcaaatgccgcagatagcggtactttgaattatgaggtttacaaaTacaataccaatgacacgtcaattgctaatgactattttaataaaccggcaaagtacattAagaaaaatggtaaattgtatgttcaaataactgtcaaccacagtcattggattactggaAtgagtatcgaaggacataaagaaaatattattagtaaaaacactgccaaagatgaacgcActtctgaatttgaagtaagtaagttgaacggtaaaatagatggaaaaattgacgtttatAtcgatgaaaaagtaaatggaaagccattcaaatatgaccatcattacaacattacatatAaatttaatggaccaactgatgtagcaggtgctaatgcaccaggtaaagatgataaaaatTctgcttcaggtagtgacaaaggatctgatggaacgactactggtcaaagtgaatctaatAgttcgaataaagacaaagtagaaaatccacaaacaaatgctggtacacctgcatatataTatacaataccagttgcatccttagcattattaatcgcaatcacattgtttgttagaaaaaaatctaaaggcaatgtggaa |
236. | atgacaaaacattatttaaacagtaagtatcaatcagaacaacgttcatcagctatgaaaaagattacaatgggtacagcatctatcattttaggttcccttgtatacataggcgcagacagccaacaagtcaatgcggcaacagaagctacgaacgcacctaataatcaaagcacacaagtttctcaagcaacatcacaaccaattaatttccaagtgcaaaaagatggctcttcagagaagtcacacatggatgactatatgcaacaccctggtaaagtaattaaacaaaataataaatattatttccaaaccgtgttaaacaatgcatcattctggaaagaatacaaattttacaatgcaaacaatcaagaattagcaacaactgttgttaacgataataaaaaagcggatactagaacaatcaatgttgcagttgaacctggatataagagcttaactactaaagtacatattgtcgtgccacaaattaattacaatcatagatatactacgcatttggaatttgaaaaagcaattcctacattagctgacgcagcaaaaccaaacaatgttaaaccggttcaaccaaaaccagctcaacctaaaacacctactgagcaaactaaaccagttcaacctaaagttgaaaaagttaaacctactgtaactacaacaagcaaagttgaagacaatcactctactaaagttgtaagtactgacacaacaaaagatcaaactaaaacacaaactgctcatacagttaaaacagcacaaactgctcaagaacaaaataaagttcaaacacctgttaaagatgttgcaacagcgaaatctgaaagcaacaatcaagctgtaagtgataataaatcacaacaaactaacaaagttacaaaacataacgaaacgcctaaacaagcatctaaagctaaagaattaccaaaaactggtttaacttcagttgataactttattagcacagttgccttcgcaacacttgcccttttaggttcattatctttattacttttcaaaagaaaagaatctaaa |
237. | LknilkvfnttilaliiiiatfsnsanaadsgtlnyevykyntndtsiandyfnkpakyiKkngklyvqitvnhshwitgmsieghkeniiskntakdertsefevsklngkidgkidvyIdekvngkpfkydhhynitykfngptdvaganapgkddknsasgsdkgsdgtttgqsesnssnkdkvepqtnagtpayiytipvaslalliaitlfvrkkskgnve |
238. | mtkhylnskyqseqrssamkkitmgtasiilgslvyigadsqqvnaateatnapnnqstqvsqatsqpinfqvqkdgssekshmddymqhpgkvikqnnkyyfqtvlnnasfwkeykfynannqelattvvndnkkadtrtinvavepgykslttkvhivvpqinynhrytthlefekaiptladaakpnnvkpvqpkpaqpktpteqtkpvqpkvekvkptvtttskvednhstkvvstdttkdqtktqtahtvktaqtaqeqnkvqtpvkdvataksesnnqavsdnksqqtnkvtkhnetpkqaskakelpktgltsvdnfistvafatlallgslslllfkrkesk |
239. | atgacaaagaaagaaaaggattataaaaaaagtcttgagcaacaaaaaacacgggtaaaaatatacaagtcaggaaaaagctgggtaaaagcaagtattaatgaaatagaattgttaaaaacaatggggctaccatttttaagtaaaaacgaaatacaagaaaatgtgactgaaaagacgaaaggtcataaattaaaaaaaagtgcagctaaaacaacagccctagttggtggagcatttacatttaatatgttgaataatcatcaagcatttgctgcctcagaaacaccaatcacctctgaaatttcatccaatagtgagacagtagccaatcaaaattcaactacgattaagaactcacaaaaagaaacagtcaattctacaagtttggaagctaaccattctaatagtacaaataagcaaatgtcttcagaagttacaaatacagctcaatccagtgaaaaagctggaattagtcaacaaagtagtgaaacatcaaatcaatcatctaagttaaatacatatgcctccacagaccatgtagagagtacaactattaacaatgataatactgcacaacaagatcaaaataagtcttcgaatgtaacctctaagtcaacacaatcaaacacgtcatcctcagaaaagaacattagctccaatttaacccagtcaatcgaaacaaaagcaaccgattcattagcgactagtgaagcacgtactagtacaaatcaaatatctaatctgacatcaacatctacttcgaatcaatcgagtcctacttcctttgcaaatttaagaacatttagtagatttactgttttgaatacgatggcagcaccgacaacaacatcaacgacaacaacttcaagtctgacatctaattctgttgtggtgaacaaagataactttaatgaacatatgaatctatctggatctgcgacgtatgatcctaaaacaggtattgctaccttaacgccagacgcatatagtcaaaagggtgccatatctttaaacactcgattagattcaaaccgtagcttccgttttataggtaaagttaaccttggtaatagatatgaaggttattctcctgatggtgtagcaggtggagatggcattggctttgcattttcaccaggccctttaggacagataggtaaagaaggggctgccgttggaataggcggtttgaataatgcctttggttttaaattggatacgtatcataacacatcaactcctagatctgatgctaaagcaaaagcagatccacgtaatgttggtggtggtggtgcttttggtgccttcgtaagtacagatagaaatggtatggctaccactgaggaatcaactgcggctaaattaaatgtacaacctactgacaattcattccaagattttgtcattgactataatggtgatacaaaagtgatgacagtgacgtacgctggacaaacctttacgagaaatcttacagattggataaaaaacagtgggggtacgacgttttctctatctatgactgcctcaactggtggcgcaaaaaatttacaacaagttcaatttggaacattcgagtatacagaatcagctgttgctaaagtacgctatgtagatgcaaatactggtaaggatattatcccgcctaaaaccattgcaggtgaagttgacgggactgtaaatatagataaacaattgaacaattttaaaaatttaggttacagttatgtggggacagatgccttaaaagcaccaaattatacagaaacgtcaggtacacctacacttaaattaactaactcaagccaaacggtgatttataaattcaaagatgttcaaggtcctcaaattagtgttgatagtcaaactagagaagttggaaagaccattaatccaattacaattactacaactgacaatagtaaagacgtattaactacaactgtgacaggtctaccttcagggttatcttttgatcaaacgactaatacaattattggcacgccaagtgaagtaggaactacaactgtgacagttaatactactgatgctactgggaacgtaacatctaagcaatttacaataacgattcaagatacaatcagccctgttgtaaatgtgacgccaagtcaagcatcagaggttttcacgccgattaatccaattacgataactgctacagataatgatggcaaagtggtaacgcatacagtaactggattgccacaaggacttaaatttgatgcatctacgaattcaattgttggaactccaactcaaataggaacaaatacaatcacgattgagtcaacggatgcgagtggaaataaaactacgactaaaattaattatgaagtaacgagaaatagcgcaagtgactctacttccactagcatagtaaatagtgtttcaacaagtataagtaatagtacatcgctaagtgatagtgtaaaagcgagtcaatcattatcaacaaaagaatcaacaagtaagagtctctcaggttcgttaagtgcgtcaacgtcgaatagtgcatcaataaaagcgagtgaatcagcaagcacaagtaagaagttatcagaatcagcgagtacgtcgatgtctgatagcgcatcaataaaagcgagcgaatcagcaagtacaagtaagaagttatcagaatcagcgagtacgtcaacgtctgatagcgcatcaataaaagcaagcgaatcagcaagtacaagtaagaagttatcagaatcagcgagtacgtcgatgtctgatagcgtatcaataaaagcgagcgaatcagcgagtacaagtaagaagttatcagaatcagcgagtacgtcgacgtctgatagcgcatcaacccaagcaagcgaatcagcaagtacaagtaaaaagttatcagaatcaacgagtacgtcgacttcagatagtgcatcaacatcaacgagtgagagtgactcaacaagtgaaagtacatcgttaagtgactcgacaagtgcgagtctttcagaatcgacaagtacatcaacatccgacagtgcgtccacatcaacgagtgagagtgactcaaacagtacaagtacgtcattgagtgagtcgacaagcacaagtctttcagaatcaacgagtacgtcaacatcagatagtgcgtcaacgtcagcaagtgtgagtgactccaatagcgcaagtacgtcattaagagaatcgacaagtacgagtctttcagactcaacaagtacatcgacatctgacagtgcgtcaacatcaacgagcgagagcgactccgatagcgcaagtacatcgttgagtggctcatcaagtacaagcgtttcagattcaacaagcgcgtcaacatcagaaagtgcatcaacgtcaacgagcataagtgactcaaacagtacaagtacgtcattaagtgaatcgacaagtacgagtctttcagaatcaacgagtacgtctacatccgacagtgcatccacatcaatgagtgtaagcgactcaaatagtgccagcatatctttaagtgagtcgacaagcacaagcgtttcagattcaacaagtacatcgacatcagaaagtgcatcaacgtcaacgagcgagagtgactccaatagcgcaagtacgtcattaagtgagtcgacaagcacaagcgtttcagattcaacaagcacatcgacatcagacagtgcgtcaacatcaacgagcgtaagtgattccaatagcgcaagtacgtcattgagtgagtcgacaagcacaagcatctcagattcaacaagcacgtcgacatcagacagtgcgtcaacatcaacaagtgtgagtgagtcaagcagtacaagtaagaagttatcagaatcagcgagtacgtcgatgtctgatagcgcatctgcatcaacgagtgaatcaaacagtacaagtacgtcattaagtggctcgacaagtacgagtctttcaggatcaacgagtacatcgacttcagaaagtgcgtcaacatcaacgagcgtaagtgactccaatagcgcaagtacgtcattaagtgaatcgacaagtacgagtctttcagactcaacgagtacatcgacatcagatagtacgtctgcatcaacaagtgagagtgactcaaacagtacaagcacatccatgagtgaatcattaagcacaagcgtttcagattcaacaagtacgtcaacgtcagacagtgcatcaacgtcaacaagtgtgagtgactccaatagcgcaagtacgtcattaagtgattcaacaagtacaagcatttcagactcaacgagtgcgtcgacatcagatagtgcgtcagagtcagcaagcgagagtgaatcaacaagtgaaagtacatcggtaagtgaatcatcaagtacaagcgtttcagattcaacaagtacatcgacatcagaaagtgcatcaacgtcaacaagcgagagtgaatcaacaagtgaaagtacatcggtaagtgaatcatcaagtacaagcgtttcagattcaacaagtacatcgacatcagaaagtgcatcaacgtcaacaagcgagagtgaatcaacaagtgaaagtacgtcattaagtggatcatcaagtacaagcgtttcagattcaacaagtacgtcaacgtcagaaagtgcatcaacgtcaacgagtgtgagcgactcaaatagtacaagtacgtcattaagtgaatcgacaagtacgagtctttcaaactcaacaagtacgtcaacatcagacagtgcatcaacgtcaacgagtgtgagcgactccaatagcgcaagtacatcgttgagtggctcattaagcacaaacgtttcagattcaacaaacacatcgacatcagacagtgcttcaacgtcaacaagcgagagtgactcgaacagtgcaagcacatcgctaagtggatcattaagtacaagcatttcagactcaacgagtacgtcgacatcagacagtgcgtccacatccacatcagaaagtgcatccacatcaacgagtgtgagtgagtcagacagtgaaagtacatccatgagtgtgagtgactcgaatagtacaagtacatcattgagtgactcgacaagtacgagcgtttcagactcaacaagaacatcaacatccgatagtgcatctacatcaaagagtgtaagtgagtcaaacagcgccagtacatcggtaagtggctcaacaagtacaagcatttcagattcatcaagcacgtccacatcaatgagtacatctgaaactttcacttctcaatctcctataaatagtgaaagtcaatttattggtgatagcttgtctgaagatacaatcgtgactcaatcaaaaaatacgaatatgcttaataaaactggaaaagattatgatttacaagaacaaagaggttatactgattcagaacaacacaatgaaacacaaagtaatcaagctgataatcactcaaacaacctcgatttacttcatcaaaatcgtttacaagataaagtcgttaaacaaccgactaaaggagaagatggagttgtaagcaacggttttatagtagcagtagcaatagtattggctatcttcggtttggcaaaaaaatctaga |
240. | atgaaaaaaacagttatcgcttctacattagcagtatctttaggaattgcaggttacggtttatcaggacatgaagcacacgcttcagaaactacaaacgttgataaagcacacttagtagatttagcacaacataatcctgaagaattaaatgctaaaccagttcaagctggtgcttacgatattcatttcgtagacaatggataccaatacaacttcacttcaaatggttctgaatggtcatggagctacgctgtagctggttcagatgctgattacacagaatcatcatcaaaccaagaagtaagtgcaaatacacaatctagtaacacaaatgtacaagctgtttcagctccaacttcttcagaaagtcgtagctacagcacatcaactacttcatactcagcaccaagccataactacagctctcacagtagttcagtaagattatcaaatggtaatactgctggttctgtaggttcatatgctgctgctcaaatggctgcacgtactggtgtatctgcttcaacatgggaacacatcattgctagagaatcaaatggtcaattacatgcacgtaatgcttcaggtgctgctggattattccaaactatgccaggttggggttcaactggttcagtaaatgatcaaatcaatgccgcttataaagcatataaagcacaaggtttatctgcttggggtatgt |
241. | atgaataaaaataaagtgattgtaattggatcaacaaatgtagataaatttcttaatgttaaaaggtttccaaaacccggtgagacattacatattaatcaagctcaaaaggagtttggtgggggcaagggagccaatcaagccatagcagctagtagattagcagcagatacaacatttatcagtaaagttggtaaagatggcaatgccaactttatattggaagatttcaaaaaagcaggtattcatacacaatatattttaacttcagaaagtgaagaaactgggcaagcatttatcactgttgatgaagcaggacaaaatacgattcttgtttacggtggtgcgaatatgacattaagtgcaactgatgttgagatgagtgtggatgcgtttattggtgcagactttgttgtagcgcagcttgaagttccatttgaggcgatagaacaagcatttaaaattgctcgtaaacaaaatatcactactgtattaaatcctgcaccggcaattgaattgcctaagtcacttttagagttaactgatataattattccaaacgaaacggaagcagaattattaacaggtatttcaatcaataatgaaagtgatatgaaagaaacagcaacatattttctcgatttaggtatatctgcagtattaattactttaggggagcaaggcacgtattgtgcatatcaagaacaatacaaaatgattcctgcgtgtaatgtaaaagcaatagatacgacagcagcaggagatacatttataggtgcttttttaagtgagttaaataaagatttgagcaatttagaatcggctattcgacttgcaaatcaagcgtcgtctctaacggtacaacgaaaaggagcacaagcttctataccaacacgtaaagaagtagaggcagaatataat |
242. | atggctcttaaaaaatataagccaattacaaatggtcgtcgtaatatgactactttagatttcgctgaaatcacaaaaacaacacctgaaaagtcattattacaaccgctaccgaaaagagcgggacgcaataaccaaggtaaattgactgttcgccatcatggtggtggacacaaacgtcaataccgtgttatcgattttaaacgtaacaaagatggaatcattgctaaagttgattcaattcaatatgatccaaaccgttcagcaaacattgcattgctagtttatgctgatggtgaaaaaagatatatcatcgcacctaaaggattacaagtaggtcaaactgtcgaaagtggtgctgaggcagatatcaaagttggtaatgctttaccattacaaaatattccagttgggacagtaattcataacatcgagttaaaacctggtaaaggtggacaacttgctcgttctgctggtgctagctctcaagtattaggtaaagaaggtaaatatgtattaatcagattaagatctggtgaagtacgtatgattttatctacatgtcgtgcaacaattggtcaagttggcaacttacaacatgaattagtaaatgttggtaaagcaggacgctctagatggaaaggcgttcgcccaactgtacgtggttctgtaatgaaccctaatgatcacccacacggtggtggtgaaggtcgtgctccaatcggtagaccatctccaatgtcaccatggggtaaacctacgcttggtaagaaaactcgtcgtggtaaaaaatcttctgacaaacttatcgttcgtggacgtaagaaaaaa |
243. | atgaagtcaaaattcacaattctattatttacaatcttttctacaacagtattagttttggttattatttataacaaaactcaatcccaatcatacatttcgactcactattctaataataaaataaaaacaacagcaacactttttttacatggttatggtggtagcgaacgctcagaaacgtttatggtcaaacaagcgttaaataaaaatgtaaccaatgaggtgataaccgctagagtgagtagtgaaggaaaagtatattttgataaaaaattaagtgaagatgcagcaaaccctattgtcaaagtagaatttaaagataataaaaatggaaattttaaagaaaatgcttattggattaaagaagttctatcacaactaaaaagtcaatttggaattcaacaatttaattttgtaggacattcaatggggaacatgtcatttgctttttacatgaaaaattatggggacgatcgacatttgccacaacttaaaaaggaagttaatatagcgggagtttataacgggattttgaatatgaatgagaacgtgaatgaaattatcgttgataaacaggggaaaccaagtagaatgaatgccgcatatcggcaattgttatcactgcataagatttattgtggtaaggaaatagaagttttaaatatctacggagatttagaagatggctcacattcagatggacgtgtgtcaaatagctcttctcaatcgcttcaatatttactaagaggtagcactaagtcttatcaagaaatgaaatttaaaggtgcaaaggcacaacatagtcaattacatgagaataaagatgttgcaaatgaaatcatacaattcttatgggaaact |
244. | atgaagattggaattgatgccggagggactttaattaaaattgtacaagagcatgacaatcgtagatattacagaactgaattaacaactaatatccaaaaagtcatagattggcttaacaatgaagaaatcgaaacattaaagcttacaggtggaaatgctggagtaatagcagatcaaattcatcattcccctgaaatatttgtagagttcgatgcatcatcaaaaggtttagaaattttattggatgaacaaggtcatcaaattgaacattacatttttgctaatgtaggtacaggtacttctttccactattttgatggaaaagaccagcaacgtgttggaggtgtaggtaccggaggcgggatgatacaaggtttaggctatttattgtccaatataacagattataaagaattaacgaatttagctcaaaatggagatcgtgatgccattgatttaaaagtaaaacatatttataaagatactgaaccaccaattcctggagatttaacagcagcaaattttggaaatgtattacatcacttagataatcagtttacatcagctaacaaacttgcctctgcaattggcgtcgttggtgaagttataacaactatggctattacattagcacgtgaatataagactaagcacgttgtatatatcggttcatcatttaataacaatcaattactacgtgaagttgttgaaaattacactgttctaagaggatttaaaccgtactatattgagaatggtgctttttcaggcgctttaggagcactttacctc |
245. | atgactttaaataaccattttgcatatacatttgaggagagacctaccccaaaattatggctttgtaaaccagatggaactagaattgaaagaattgcagatttttcaaaacttggtggaacattcaaattcactaatgtgaacactttacattttgatttgccattgcaagtatttagtgaagatactaagcaaattgaaagaaataaagtagttgatttagtaaaaaataaatacttaattgattatagatataacggatatagagatatctttgtaattgatgatattaaaaaatctgctaatgactctgattttattacattaaatttagactcaagagcgtctgaattaaataagaaagctgcaaatgaaattgaattattaggttctactatccctcaaatgatgaacaaaatcttatcagtttatgctccactatggaaacttggacatgttgatggaaaaattattgatgttaaacgtgagttaactggttctaatacaactgttaacgctcttattgataatatttgttctctttttgacgcagttgctatttataacaacattaatagaacaataagcttctatcataaagacaatgttggtactaatcgtggtttaagagttagggaaaatagttatttaaaatcatttgaagatcaatttgtatcaaaggatatcgttactagattatatccatttggtcaaagtggtttaacaattcaaagtgttaacccagctggctcttcttatattgaagacttctcttatttcatgtcaccattcaaacgtgataataacagaaatgtattacaacatagtgattatatgtctgatgaattatgtcacgctttgttagattatcaagagttttatgctagtaagaaggatcaagctggtgaattatctaaacaatatagtgcaattcttaaagagcattcacaagaagacttcagattaaatcaattaagtgctacacttcaacgactaaatgagcgtgttgaattagttaaacctaaatcagaatatattgacttaggaacaaaggttaagaatttcaaaatcactgtacctaaatcatcatattatttaatcatgattagaaatgatggtagtttcactagaattaaattcaataataaacagtatgatattccaagtggtgagtggttgtatatcaaacttaaaactggtaagtttaatgacgctactaagtttgagaaacaattagaataccctcttgaaatattaagtgcaaacgctaatttaagagtggtatatactcgttcttctgaaggagattatgaagaagaagatactaagacaatcgaagaaaaatacaacttagaaaaatataaaattttagtaaaagatcaagaaaaagtagtcgcttcaatcgaaagacgattaaaagcttttgaagaccaaaaagcaagtgtaatacgttcaatgaatgcaaagaatttcttatctgaaaaactttataatgaacgtgagttatatgtttttgagtctgtttggacggaagaaaatcatacagacgctcaagaattatatgatgacgctgtaaaacaaatgaaggaacaaaagaaaatcaatagaacgattacagttgatttagttaacttcattcaatcgcttgaccataaagatgattgggataaattaaatgttggagatssagttgttttccaaaacaaaatcttcaatactaaaatcaaagcctatatcactgaaatgcaattagatttccaaactaatcaagtaaaaattactattagtgatatttttgattacaaagatttagacacaatcatcgctgaaaaattagcccaaactacctctacttcttctcaagttgatttccataaacaacaaattagagagcaaaccggaagaattacagatatgactcgtcttatcgaaggtgagtgggacgcaaataaaaagcgtgtgatggctggtaatgaaacagttgatattggttcacatggtgttaaagtcatttcaaaagagaaccctaacgaattcgtaatcatggttggtggcgtaattgctatgactcgtgataacggtgaaacatttaaaactggtattacaccagaaggtatcaatgctgaaatgcttatcggtaagatgatcgttggtgaaactttaacttttgaaaatgagtctggtacagttaaattcgacaaagatggactttatgttaactctaaaaacttccatttagtttcaaatgatggagaagaagactacttcgataaattaaaacgtgaaatgtctgaaaacgctaaacaacaaacagacagaatgttagaagagtataaaaaagaagtttcacaaactatttctgaagctactgacgttagaaacattgttgataatgcagcagatattcttcaagcagcttttgctgatggagttatcacagatgttgaaaaacgtttgatttctgaaactcttgctcaacttgaaaaagaaaatagagaattcgaagataaaattaacttagctttaaaccacccttacatcactgaggaagatactattgagttaaataattctatcgttgaatatagctcaatgtatgaaacacttgttatttctattaatgaaagtgttagtgacaagatgatcacacctcaagagtctgaagaaattaatcaaaatattataaacttcagagaagagatcaaagacatcttatcattagtagaagaaattattgaacgaactaaaaatgctcaactacaagctactttagaagaagcaaaagattatacaacaagagttcgtgacgatattaaagatgaattaaaagacttaaataattcatttaaatctttaaatagtacagttgaagagtcattacaagataatatttttgacgctgctgaattagaagctattaaaacagttgtattagtaactaaatcagaatatcaagatattacaaatagatattcttcaatgtctgcaaatacagatttaaaatcggaaagtaaattagatttaacaaaatcttataaaactttagatactagctttaatgactttgttaaatatattgacgaaatgacaatggatagaattgcagatgagactgagaaagttaattacaaaaagaaatatgatactttacaaaagaacttatcagattatatgaaaaaatatgataactgtattttggaaatatctaaaaagtattctaatgacgcagcagataaagtgttaggtgacttcacagctattgctactgaattacaaaatgatttccaagatgttaaagacaattgggctgaattcaagcaaactactcttgagtcatttaaagatggtatagtaactgaggcagaaaaagctcgactaagagtacaattagatatgcttgatcgtgaaagcatggatattgaagaacgatataaaagcttacttgctaaccaatatactaatactgatattaaaaatcgcttaactgcttcacgttctccttacttatcagttcatgctagtttaagaaaagtaattgaacaaataattgctgacggaaaagttgatgaaagtgaaaaaacattagctaataattcacttaatacatacaacacaacattaactgcttattctaaaacaattcaagaagctctaaatacattatcacaaatcatctcttctgatgtagcaagtaaaaaagttgaagaattcaatggtgtaataactacaatttcttcagacgttgatacaatcaagaaacaaagagatggtgcagtaatcacttattattatagcggtgtacctacattatctaacgatccagctaaaagttggacgactaatgatttaaaagacttacatattaaagatatgtatttagacactaaatctggttatgcatatactttcactaaatctggtactagttattcttggaaaccacttactgaccaagttattgttagctcattgaaacaagcaaaaaatgcacaagacacagcggacaataaacgtagagtttttgtaactcaacctattcctccttatgatcaaggagatatgtggactcaaggttcacaaggagatatttatgtctgtggaacttcgagagctactggctcattcgtaagtagcgactgggttaaagcgagcaaatacactgacgatacagtagctaaacaggcagcaaaagatttagaagattataaagtcaaaatgactaaagacttcaaagatttaaatgacggtgtatctacttttaaaactgaagtggttaaagatttcaaagatggaattgtaactgaagctgagaaaactagattacgtgttcaattagatatcttagatagagaaagtcaagatatcgaagaaagatataatagtatctttaacagtcaatatgcagatactcaagttaaaacttctatttctaacgcacgctctacttataataactctcttactaagttaagaaacactattcaaaccgtgattgaagatggaaaagtaacgcctactgagaaaactactgctaatcaaactttaaccgcatataataatgctttaacgagttattcagctgctatccaagaagcattaaatagcatgtcaaaagtaattgctcaaaaagaagctactagtcaagtaaatcaattcaatgaagttataaaaaatataaatacaaatattactgatattcaaaaacaagttgatggtgcaattgaaactttctattacagtggagtaccaacacttactaatatccccgcttcgtattggacaactgctagtaaacgtgaagctcatttaggtgatttatatttagacactgctactggtgttgcttatcgtttcttaaaaaaaggaacaacttcccctacttactattggtctccaatttctgatcaaattattacagacgcattgaatagagcaaaaacagctcaagacaccgccgatggaaaaagaagagtttttgtaaatacacctgttccaccatacgacactggtgacatgtggacgcaaggagctagtggtgacatcttagtttgtaaaacacctaaagctaaaggtggtatttactcaataagcgactgggtaaaagctagtaagtatacagatgatacagtagcaaacagtgctgttcaacaattaaatgaatacaaacgcactaataatcttgatatcgcagacctaaagagaaaaactagtgacttcgaaaaaacagttgtaaatgcatttgacgatagagtcattagtatttccgagtcttcatctattaaaggacaacttgctctacttaatcacgaaaaagatagattaactagacaatacgaaaatataatcagaaattctaatcttgttggagcagaaaaaactaaattatctactgcatattcaaatataaatactaagcttagtgatttaagtacaactattaatagtgcaattgttgataataaaattgttgacgctgaaagtaaatctgtaacttcaaaatttgaattgtataaagcttcagttaatgaatatcaaatcgcttttgataatgctctaaactcaattattagagaaatcgct |
tcttcccaagctaaagatagattagatgaatggaaacgtacagaatttagtacagactcagacggtattattgaaagagtagctggtgctaagtttgactcaaaatggactgatacttggagaaatacagttaacccagctattcaacaagtgagtaatataacatatggaagtgaaaacctattacttaatagcgaaagtcgaagtgacggtgctaataccacgactcactcttttataagatactacctgacacgccctttagaaacagggaaaacttatactttaaaagctagtgttttaacaactgatgaaagacaaagtggacaaattagtgtttatccatactcccctaacggagcaagagagacagtaaatattaaagacggtaaaattacttatacatttactgcacaaactgaaagtacacaatttcttatttataaagacgtggctggtcaatctgatgtagacttaaatgtaacaatcgagaaggctattttagtcgaaggaaataaagttacagggtggtctccagcaccagaggagacttcttctgctttacgagattataatactcgtatctcctcagcagaaacattcattgagaaaaacaaagaaaagatttctcaaattgctactaaatctgatgttgacgcttcacttagtaaagtagctacttatgaaactcaatataatgtttctagcggaactaactatcaaattcctcttcaagaatacaatggttcattctttaccgacaactacacttatgaagttgtagctaaaaataactctttaagttctaacaacgtagcaactgctatattcgtaagtaaaggttcaaacaatggttatgaattggttgaattagacaacatgtctaaaactggtgctaaccctagatttgttttagacagtaaaggtagaccttctatctctactttctcccctcaatctactactcaagatatttcagttatttacactaaatatttaggtagtgcttcagcaatcaatacaactaaatcattgattgagcaaactgctagttctattgaattacaagttaagaaacttactgctgagactgaatacaacaacatattattaaattcagacttctcttctggctgggaaggttggataaatgttgatcctcagtatagtattgttgataaaaatacttttggtatcactcttcctgacgcaatcactaataaaaataagaaatataatacagttaaaatgacatacaataaaaatacaaattacccttctgtattttctaattttatttctgttggaaaaggtcaagaggtagctattggtgaacatttaacactaacttgttatgcctatatcccttcttcatctaaaggtaaattaactggtaacatatatattgaattcgctggttactatgaaaaagaccaaaaatcaaacccaatgattgctagacatgaaatattacctaaagattttgaatataataaatggttcagaatgacagctagtactgctattccttctactaactctgagggtaaaaaaatcaattatattagagcttgtttacgttatgacggtaaaaatcaaagcgtaaataatagtgctatattctattatgcgttacctcaattagagcgtggatcaaaaccaaccgagtggtcgttatcaagacttgacgtatttagcactgaacaattggcagctaagattgccttaaacccagagagtgtggatattatcgcaagaaatattgatttcaatactgactcaatgaagatttataattctaacggtacattaaacatttctggagatactttaacaattagtaacaacaatagttctaatgaagtaattataaatccaaaaggttttacacttaaaaaagatggtgtagttaagtttaaaaatggactagacacaagcgattatagtgtccaagcttatgaaccacagtttagttcatggaataatattaaagctactgatcccgctgctaagagtaagtataattacattcgacatattgagccggggatgaatggttattacactataaatactggtgtttacaattttgcagtacaacacaaacaactattagaggtaaataatacaaaaaatgcgagagttaacaggtatacatatctttacaacaaaaggtatttaaaaatacaaatgtctgcttcttctcgaggtaaaagtaagctttatataatattcaagacaaaaactggagatactacactccatcaagaaatagttagttctagttcaatggtatacccagatataacaattgacttacaggctaaattaggttatccgcctaacaatttgccagacttttttgaattacaagctggtattgcctatggagaaaataattctattgatggtttctttagaattagacgtatggcaatgacagatacaccaaatgcggaggtt |
246. | atgtataacgtgacacagcatgcgacttataaaacaaaaaataaacgagaaactgctgtattaatcggtgtacatgctcaaacggatcgtcaatttaattttgaatctactatggaagagctcgatgctttatcacaaacttgccaacttaatgttaaaggacaaatcactcaaaatagagagcaatttgaccataaatattatgttggaaaaggaaaaatcgatgaaataaaatctttcatagaattccatgatatagatgttgtcgtaaccaacgatgaattaacgacggcacagtctaaaacgttaaatgataatttgggcattaaaatcatcgatagaacccaattaattttagagatattcgcgttgcgagcgagaagtagagagggaaagctacaagtagaacttgcacaactcgattatttgttaccaagactacatggtcatggtaaaagcctgtctcgtcttggtggtggcataggaacaagaggcccaggtgaaacaaaattagaaatggatcgtcgccatattagaacacgtatgaatgagattaaacatcaattaaaaacggtcgtggatcatcgggaaagatatagaaataaacgtgaacaaaatcaagtttttcaaatcgctttagttggttatacaaatgcaggaaaatcgtcatggtttaatgttttagctaatgaggagacctatgaaaaaaatattttgtttgcaacattagatcccaaaacacgacaaatacaagtgaatgaaggatttaatttaattatttctgatacggtaggatttattcagaaattaccaacgacattggtggctgcgtttaaatctacactagaagaagctaaaggtgcagacgtacttatgcatgtcgtcgatgcaagtcattcggaataccgtactcaaattgacactgtaaatcaaattattaatgatttagatatggaccatattccacaagtagttatttttaataaaaaagacttatgtaacgaacagatggatgtacctgtatctaaatctgcgcatgtttttgtatctagtcgtgatgaaaatgataaacaaaaggtgaaaaatttagtaattcaagaaataaaaaatagtctcagcccatacgaagaaattgtagatagtgctgatgcagatagattatattttcttaaacaacacacgcttgttactgaattaatatttgacgaaacacaagcatcttatcgtatcaaaggatttaaaaaatta |
247. | atgatgatcatcgtcatgttaatcttgagttatctgattggtgcattcccaagcgggttaattattggtaaattattttttaaaaaagatataagacaatacggtagtggaaatactggagcaactaacagttttcgtgttcttggaagaccagctggatttatagttacgtttttagatattttcaagggatttattacagtcttttttccactatggttcccagttcatgcggatggtgttataagcaccttctttacaaatggtttaatagtaggattgtttgcaatactcggtcacgtgtatccaatatatctgaaatttaatggcggaaaagcagtagctaccagtgcaggagttgtattaggtgtcaatcctattttacttcttatcttggcaattatcttttttagtgtattaaaaatctttaaatatgtttctttatcaagtatcattgcagcaattagttgtgtgattggttcaatcatcattcatgattatattttacttgctgttagcggaattgtttcaatcatattaataattcgacacaaatctaatatagttagaatttttaaaggagaagaacctaaaattaaatggatg |
248. | atgatgaatcatagtgaagctttaactgaacaagtattttcatttgcttcagagctttatgcttatggtgtaagagaagtagtaattagtccaggttcacgttcaacaccattagcacttgttttcgaagcacatccaaatattaaaacatggattcaccctgatgagcgaagtgctgcattttttgctttaggtcttattaaaggtagcgaaaaacctgtagcaattctttgtacatctggaacagccgctgcgaactacacacccgctatagctgaaagtcaaattagtcgtttgcctctcgttgttttaacgagcgacagaccgcatgaactgcgcagtgtgggtgcacctcaagcaatcaatcaggtaaatatgtttagtaattatgtgaactttcaatttgatttgccgattgctgatggaagtgaacatacaattgatacaattaattatcaaatgcaaattgcaagtcaatatttatatggaccacaccgaggaccgattcattttaatttaccatttagagaaccactaacaccagatttagatcgtgtcgatttattaacatctgtaactaaaacgttacctcattatcagaaatcgatttcggtagatgatataaaagacatattacaagaaaaaaatggtctcatcattgtcggagatatgcaacaccaagctgttgatcaaatattaacgtattcaactatatatgatctgccaatcttagcagatccccttagtcagcttcgtaaagagaaacatcctaatgttataaccacttatgatttattgtatcgagcaggattaaatttagaagtagactatgtcatacgtgtaggtaagccagttatttctaaaaaattaaatcaatggttgaagaaaaccgatgcgtatcaaattattgtgcagaataatgatcaaattgatgtatttccgacaccacctcatatatcttatgagatttcagcaaatgattttttccgttcattaatggaagaaccacttgttgaacgaaaaaaatggttacagcaatggcaatcacttgaacaacaagcacgcattgaaataagtgattacttaaagcatgcgacagatgaagcggcatatgtagggagtttaattcaaaaacttacaaaagaagatacattatttgttggaaatagtatgccaattagagatgtcgataatttactgtttgatagtgaggcatctgtatacgctaatcggggtgccaatggaatagacggagtagtttcaactgcgctaggtatggcggcacataagaatgtgacattgcttattggtgatttatctttttatcatgacatgaacggtttattaatggccaaattaaatgaacttcatattaacattgtattagttaataacaacggaggaggtatcttttcatatttacctcaaaaacgatcggctacaaaatattttgagcgattatttggaacaccaacaggcttaaactttgaatatactgcactgttatatgattttacatttaagcgctttgataatttgactgactttaaatatgctgaattatctaaaatgggttctcacatgtatgaagttataaccaatagagacgaaaatttgcatcaacaccaaaatttatatcagaaattgagtgagattgttaatgttacatta |
249. | atggcgaaaaaattcaattacaaattaccgtctatggttgctttaacgttatttggcacagcttttactgcacatcaagcaaatgctgctgaacaaccacagaatcagtctaatcataaaaatgtattagatgatcaaactgccctcaaacaagcagaaaaagctaaaagcgaagttacacaatcaactacaaatgtatctggtacacaaacatatcaagaccctacccaagttcaacctaaacaagacacacaaagtactacatatgatgcatcattagatgaaatgagtacttataatgaaatttcatcaaatcaaaagcaacaatctttatcaacagatgatgcgaatcaaaatcaaacgaattctgttacaaaaaatcaacaagaagaaacaaatgatttgacacaagaagataaaacatccactgatacaaatcaattacaggagacacaatctgtagcaaaagaaaatgagaaagatttaggagctaacgcaaataatgaacaacaagacaagaagatgactgcaagtcaaccttccgaaaatcaagcaattgaaactcaaactgcttctaatgataatgaaagccaacaaaaaagtcagcaagtaacttctgaacaaaatgaaactgctacacctaaagtatcaaatacaaacgcatctggttataattttgattacgatgatgaagacgatgatagctcaacagaccatttagagcctatctcattaaacaatgtgaatgctacatctaaacaaactacttcatataaatataaagaaccagctcaacgtgtaacaactaatactgtaaaaaaagaaacggcatctaatcaagcgactatagatacaaagcaattcaccccatttagtgcaactgctcaaccgagaacagtttattctgtatctagtcaaaaaacatcatcattaccgaaatatacaccaaaggttaattcttcaataaataactatattcgtaaaaagaatatgaaagcaccaagaattgaagaagattatacgtcatatttccctaaatatggctatagaaacggtgtgggacgtcctgaaggtatcgttgttcatgatactgcaaatgataactcaacaatcgatggcgagattgctttcatgaaacgtaattacacaaatgcattcgtacacgcatttgttgatggcaatagaattatagaaacagctccgacagattacttatcttggggtgcaggtccatatggaaatcaacgttttatcaatgttgaaatcgtccatacacatgattatgattcatttgcacgttcaatgaacaactacgctgattatgctgcaacgcaattgcaatattataatttaaaacctgatagcgctgaaaacgatggaagaggaacagtttggacacatgctgctatctctaacttcttaggaggtactgatcacgctgaccctcaccaatatttaagaagtcacaattatagctatgcagaattatatgacttaatttatgaaaaatatttaattaaaacgaagcaagtagcaccttggggcacaacatctacaaaaccgtcacaaccttctaaaccatcaggaggaactaataataagttaactgtgtctgctaatcgtggtgttgctcaaattaaaccaacaaataatggcttatatacaactgtttatgacagtaaaggtcataagactgatcaagtacaaaaaactctatccgttactaaaactgcaacattaggaaataacaaattctatttagttgaagactacaatagcggtaaaaaatacggttgggttaaacaaggtgatgttgtttataacactgctaaggcaccagtaaaagtgaatcaaacatataatgttaaagcagggtcaacactttacacagttccttggggtacaccaaaacaagttgctagcaaagtatctggtactggaaatcaaacatttaaagcaactaaacagcaacaaattgataaagcaacgtatctttatggtacagtgaatggtaaatctggttggattagtaaatattacttaactacagcatctaaacctagcaatccaactaaaccttcaacaaacaaccaattaacagtgactaacaatagtggtgttgctcaaatcaatgcaaaaaatagtggcttatatactacagtttatgacactaaaggaaagacaacaaatcaaatccaacgtacattgtcagtgacgaaagctgccacacttggtgataaaaaattctatcttgttggtgattataatactggtacaaattatggttgggtaaaacaagatgaggtcatttacaacacagctaaatcacctgtaaaaatcaatcaaacatacaacgtcaaacctggtgttaaattacacacagtaccttggggcacatataatcaagtggctggaacagtttcaggtaaaggcgatcaaacttttaaagcaactaaacaacaacaaattgataaagcaacatatctttatggtacagtgaacggtaaatctggttggattagtaaatactatttaactgcaccatcaaaagttcaagctttgtctactcaatcaacaccagcacctaaacaagtaaaaccatctacacaaactgtaaatcaaattgctcaagtgaaagctaataattctggaataagagcatctgtttatgataaaacagccaaaagtggtacgaaatacgctaaccgtacattccttatcaataaacaacgtactcaaggtaataacacgtatgtactacttcaagatggaacaagtaatactccattaggatgggtaaacattaatgatgtgacaactcaaaatatcggaaaacaaactcagtctataggtaaatattcagtaaaacctacaaataatggtctatattctattgcttggggtactaaaaaccaacaattactagcacctaatacgctagctaatcaagcatttaatgcttccaaagctgtttacgttggtaaagatttatatctatacggtacagtcaataacagaacaggatggattgctgctaaggatttaatccaaaacagtactgacgctcaatcaacaccatataactatacttttgttatcaataatagtaaaagttatttctatatggatccaacaaaagcaaaccgatattctttaaaaccatattatgaacaaactttcacagtcattaagcaaaaaaatattaatggcgttaaatggtactatggtcaacttttagacggtaaatatgtttggataaaatcaactgacttagttaaggaaaaaattaaatatgcatatactggaatgactttaaataacgcgataaatatccaatctcgtcttaaatataaaccacaagtacaaaatgagcctttgaaatggtcaaatgctaattatagtcaaattaaaaatgctatggatacaaagcgtttagctaatgattcatccttaaaatatcaattcttacgtttagatcaaccacaatacttgtcagcacaagctctcaataaattattaaaaggcaaaggtgtacttgaaaaccaaggcgctgcatttagccaagctgcacgtaagtatggtctaaatgaaatttatcttatctcacatgctttagtagaaacaggtaatggaacttcacaacttgctaaaggtggagatgtttcaaaaggtaaattcacaactaaaacaggtcacaaataccataatgtctttggaattggtgcatttgacaataatgcacttgtagatggtatcaaatacgctaaaaatgctggatggacttctgtctctaaagcaattattggtggcgctaaattcattggaaattcatacgtgaaagcaggacaaaatacgctatataaaatgcgttggaatcctgcaaaccctggtacgcatcaatatgcaactgatattaattgggcaaatgtcaacgcacaagtattaaaacaattttatgataaaattggtgaagtcggtaagtacttcgaaattccaacatacaaa |
250. | gtggcatttgaatttagattacccgatatcggggaaggtatccacgaaggtgaaattgttaaatggtttattaaagccggcgatacaattgaagaagatgatgtattagcagaagttcaaaatgataaatctgtagtagaaattccttctccagtaagtggtactgttgaagaagtgttagtagatgaaggaacagtggcagtagtaggagatgtcatcgttaaaattgatgcacctgatgcagaagaaatgcaatttaaaggtcatggcgatgatgaggattctaagaaagaagaaaaagaacaagaatcaccagtgcaagaagaagcttcatcaactcaatcacaagaaaagacagaagtagatgaaagtaaaactgttaaagcgatgccgtcagtgagtaagtatgcacgtgaaaatggtgtcaatattaaagctgtaaatggttctggtaaaaatggacgaatcacaaaagaagacatcgatgcatacttaaatggtggtagttccgaagaaggttcaaacactagcgcagcatctgaatcaacttctagtgatgtcgttaatgcttctgcaacacaagcattaccagaaggcgacttccctgaaactacagaaaaaatacctgcaatgcgcaaagcaattgctaaagcaatggttaattctaaacacactgcacctcatgttacattaatggatgaaattgatgtgcaagaattatgggatcaccgtaagaaatttaaagaaattgctgctgaacaaggtacaaaacttactttcttaccatatgttgttaaagcattagtttctgcacttaaaaaatatccagcacttaatacttctttcaatgaagaagctggagaggttgtacacaaacattactggaatattggtattgctgcagatacggataaaggattattagtaccagtagttaaacatgccgatcgtaaatcaatattcgaaatttctgatgaaattaatgaactagctgtaaaagcacgtgatggtaaattaacttcagaagaaatgaaaggtgcaacatgcacaattagtaatatcggttccgctggtggacaatggttcactccagttatcaatcacccagaagtagctatcttaggaattggccgtatcgctcaaaaacctatcgttaaagatggagaaattgtagctgcaccagtgttagctttatcattaagctttgaccatagacaaatcgatggtgctactggacaaaatgctatgaatcacattaaacgcttattaaataatccagaattattattaatggagggg |
251. | atgaatgaaacagacgaaatttcacaaatctataacaagcatcgattaccaagtttaagtggtctagcaaaagtgtctccacttgttcatagggccagcataggaggcgttttaaatgtggcagaattaaacagaattaaacgcctagttcaagtgcaaaatcaatttaaaacattttacaatcaaatgctagaagaagatgaagaggttaagtatcctatactgcatgataaaatgaatcatctaccgatacttacagatttatttaaagaaattaatgaaacatgtgatgcacacgatttatttgaccatgcaagttatactttacaaagtattagaagtaaaatttcaagaacaaaccaacgaattcgtcaaaatttagatagaatagtgaaaaatcaagggaatcaaaaaaaactatctgatgcaattgtaacagtaagaaatgatcgcaatgttattccggtgaaagctgaatatagacaagatttcaatggtattgttcatgatcaatcggcatcaggacaaacactatatattgaaccgaattctgttgtagagatgaataatcaaatcagtcgtttgcgtaatgatgaagcagttgaacgtgaacgtatattgactgaattgacgggatttgtttcggcggaagctgacgcattactcattgctgaatcggttatgggtcaaattgattttttaattgctaaagctcgttatgcgcgcactataaaagggacaaaacctacatttaaagaggatcgaactatatatttacctaatgcatttcaccctttattagacaaagatactgttgtagcaaatacaattgaatttattgacgatgtagaaacagtcataattactggaccaaacacgggtggtaagacggttactttaaaaacactaggattgataattgtcatggcacaatcaggattgttaattcctacactggatggaagtcaattaagtatctttgaaaatgtatattgtgatattggagatgaacaatctatagaacaatcattatcaacattttcatctcacatgaaaaatatagtagaaatattacaagatgcagatcaaaatagtctcattttatttgatgaactaggcgcaggtacagatccaagtgaaggtgcggcactcgcaatgagtatcttagattatgtacgccgtttagggtctttagttatggcaacaacacattaccctgaattaaaagcttatagttataatcgtgaaggtgtcatgaatgcaagcgttgaatttgacgttgaaacactgagcccgacttataaattattaatgggtgttccagggagatctaatgcctttgatatatcgaaaaaacttggtctaagtctcaacatcattaataaagctaagacaatgatagggacagacgagcaagagatcaatgccatgattgaatcattagaacaaaattcaaaacgtgttgatcaacaacgtatagaattagatcgacttgtgagggaagcacagcaaacccacgatgctttgtctaaacaataccaacagtatcaaaattatgagacatcattgatggatgaagctaaagaaaaagctaatcagcgtgtgaaatctgcgactaaagaagcggacgaaattcttaaagaacttagaaatctaagagatcataagggcgctgaggtaaaagaacatgaattaattgataaaaagaaacaacttgatgatcaatatgaggtaaaatcaattaagcaacatgttcaaaagaaaaagtatgatacgattcatactggagatgaagtgaaagttctatcttacggtcaaaaaggtgaagtgcttgaacttgtaggtgacgaagaagcagttgtacaaatgggaatcattaaaatgaaattacctattgaagatttagaaaaaacgaaaaagaaaaaagaaaaacctacaaaaatggtaacaagacaaaatagacaaactattaaaacagaactagatttaagaggatatcgttacgaagaagctttaaatgaattagatcaatatcttgatcaggcggttttaagcaattacgaacaagtttatattattcatggtaaaggtacgggggcacttcaaaaaggtgttcaacaacatttgaaaaaacataaaagcgttagacaatttaggggaggtatgcctagtgaaggtggatttggtgtcactgtggcagaactcaag |
252. | atgagtttttttaaacgtctgaaagataaattttctagtaaaaatgaagatgatattcaaaaagacctggatgaatctgtagattcaaatgttaacagtgattcagattcaatggatccgaatgattctgatgaacaagttaaacccaaaaagaaacctaaaaaattaagtgaagctgattttgacgaagatggcttgatatcgattgaagattttgaagaaatagaagctcaaaaaattggagcaaaattcaaggccggtttggaaaaatcacgtcaaaacttccaagaacagttaaataatttaattgctcgatatagaaaagttgacgaagatttcttcgaagctctggaagaaatgcttattactgcggacgttggttttaatactgttatgaaattaactgatgagctacgtacagaagcacaaagacgtaatatacaagaaacagaagacttaagagaggttatagttgagaagattgtagaaatctatcatcaagaggacgatcattctgaagcaatgaatattgaagatggacgtttaaatgtcatactgatggttggtgtgaatggtgtcggcaaaacaacaacaattggtaaattagcttatcgttatcaacaagaaggtaaaaaagtaatgttagctgctggtgatacttttagagctggagcaattcaacaattaaacgtctggggagaacgtgttggcgttgaagttgtgagtcaaaacgaaggttctgaccctgcagcagtagtatatgatgcgattaatgcagcaaaaaataaagacgtagatattttaatttgtgacactgcaggacgcttgcaaaataaatctaatttaatgcaagagttagataaaatgaaacgtgtgattaatcgagcaatacctgatgccccccatgaagctttattatgcttagatgcaacaactggtcaaaatgcactttcacaagcacgttcatttaaggaagttacaaatgtctcaggtatagttttaactaaattagacggtactgctaaagggggtattgtattagcaattcgaaatgagttacacattccagttaaatatgttggtttaggtgaaaaaatggatgacttacaaccgtttagtcctgaaagctatgtatatggattatttgctgatatgatagaacaaaatgaagatattcctgaagaaatctctagaaattcatccgttgaatctgaagaaggtaac |
253. | atgaaaagaaattggtggaaagaagcagttgcatatcaagtatatccacgaagttttaatgatagtaatggagatggaataggtgatctacctggattaattgaaaaattagattatctagaaaatttaggaatagatgtcatttggttaagcccaatgtatccatcaccaaacgatgataatggatatgatattagtgactacaaaggcattatgagtgaatttggtacaatgaacgattttgatcaattgttatcaagcatacatcaaagagggatgaaattaatattagacttagtggttaatcacacatcagatgaacacccttggtttattgaatcaaaatctagtaaaacaaatgcaaaaagagactggtatatttgggcagatcctaaaccggatggatctgaacctaataactgggaaagtatctttaatggttcaacttgggagtttgacgaatcgactaagcaatactatttccatttatttagcaaaaagcagccagatttaaattgggaaaatccagatgtaagacaagctgtgtttgaaatgatgaattggtggtttgaaaaaggtattgacggatttagagttgatgccattactcatattaaaaagaattttgaagcaggagatttacctgtacctgatggcaaaaaatttgctccagcatttgatgtagatatgaatcagccaggaatacaagaatggctccaagaaatgaaagataaatcgttaagtcggtatgacattatgactgtaggcgaggctaatggtgttactcctaatgatgctgaagaatgggtaggagaagaaaatgggaaatttaatatgatattccagtttgaacatcttggtttatggagtactggcgatacgaaattcgatgttaaatcctataaacaagtcttaaatcgttggcaaaagcaactagaaaatgtaggttggaatgctttatttatcgaaaaccatgatcaaccacgtcgtgtttcaacctggggtgatgataaaaattattggtatgaatcagcaactagtcacgctactgcctactttttacaacagggcacaccttttatttaccaaggtcaagaaataggtatgactaattatccatttgaaagcattgaaagtttcaacgatgtcgcagtgaaaactgaatatcaaatagtcaaaaaagaaggtggagatgtcaatcaattactagataaatataaaatggaaaaccgagacaatgcaaggactccaatgcaatggaataattctatcaatgctggattcactactggtaagccatggtttcatgtaaaccctaactatacagaaattaatgttaaacaacaactaaatgataagttttcgatactttcttattataaagcgttaattcaactaaaaaaatctgatttgatttacacctacggtaagtttaatatggtcgatgctgaaaataagcaggtttttgcatatacacgcacatttaaaaacaatactgtattaattgtagccaatctcacaaatgaagtatcagaactaaacctaccttttgaattagatatttcatctgtagatataaaattgcataattatcacttaaatgatataaatttagaccatattaaaccttatgaatcattcgtcgttgaaata |
254. | ttgagtcatagaaagctatttccttctatattccatttatatcaacaagacaatttagatgaacatattgctattattggtataggacgtcgcgattataataacgaacaatttcgcgaccaagttaaagcgtcaattcaaacttatgttaaagatacagatagaattgatgagtttatgacgcatgttttttatcataaaactgacgtgagtgataaagaaagttatcagtcattacttcaatttagtgagcgactagattcagaatttgctttaggtgggaatcgtctgttttacttagcgatggcaccacaattttttggagtgatctcagattaccttaaatcttctggtcttactcaaactacaggatttaaacgcttagttatagagaaaccatttggcagtgatcttaaatctgctgaatcattaaataatcaaataagacgttcgtttaaagaagaagaaatttatcggatagatcactatcttggcaaagatatggtgcaaaatatagaagttttgcgattcgcaaacgcgatgtttgaacctttatggaataataaatacatttcaaatattcaagttacatcatcagaagtattaggtgtcgaagatcgtggtggctactatgaatctagtggtgcacttaaagacatggtacaaaatcacatgctacagatggttgctttacttgcaatggaagcaccgataagtttgaatagtgaagatatacgtgcagaaaaagtcaaagtacttaaatctcttagacaattaaaaccagaagaagttaaaaagaatttcgtgcgtggtcaatatgatcaaggcaatatagatggtaaacaggttaagtcatatcgagaagaagatcgcgtagcaaaggattcggttacaccgacatttgtatcgggtaaattaacaattgataactttagatgggctggagttcctttctacattagaacgggtaaacgtatgaaatcaaaaacgatacaagtcgtagtagaatttaaagaagtacctatgaatttatattatgaaactgacaatttactagattctaatttgctagtcattaatattcaaccaaatgaaggaatttcattgcatttaaatgctaaaaagaacattcaaggaattgatactgagccagtgcaattatcatacgcaatgagtgctcaagataaaatgaatacagttgatgcatatgaaaacttattgtttgattgtcttaaaggtgatgcgactaattttacacattgggaagaattaaaatctacttggaaatttgtagatgcaatccaagatcaatggacaatggttgaaccatgtttccctaactatgaagcgggtacgaatggacctcttgaaagtgatcttttattaagtcgtgatggaaatcattggtgggatgatatccac |
255. | atgattaaaaaaaacaaagaagaactgaatgacatggagtatctagtcactcaagaaaatggtactgaacctccgtttcaaaacgagtattggaatcactttgaaaaaggaatttacgttgataaattgtccggcaaaccattatttacttcagaggataaatttgaatctaattgcggttggccaagtttctccaaagcattaaatgatgatgaaatcgtagaacttgttgataaatcatttggtatgattagaactgaagttcgatcagaaaaagcaaatagtcacttggggcatgtttttaatgacggacctaaagaaaaaggtggtttaagatactgtattaactctgctgcgattcagtttataccttatgataaactagaagagttaggatatggagatttaattaaacattttaaaaaat |
256. | ttgaaaaagttagcctttgcaattacagccgcttcaggcgcagcagcagttctatcacatcatgatgctgaagcttctacacaacataaggttcaatctggagaatccttatggactattgcacaacaatacaatacttcagtagaaagcattaagcagaataataatcttagcaacaatatggtattcccaggacaagttattaatgtaggtggaagtgcttcacaaaatactagttcaaacacttcttcaagttcagcatcttcacatactgtagtagcaggtgaatcattaaacatcatagctaataaatatggtgtttcagttgatgcattaatgcaagcaaatcatctaaatggttatttaattatgcctaaccaaatattaactatccctaatggtggttctggttcaggatcaggtggtacagcaactcaaactagcggtaattatacttcaccttcattcaaccatcaaaacttatacactgaaggtcaatgcacatggtatgtgttcgacaaacgttcacaagctggtaaacctatcagtacttactggtctgatgcaaaatactgggcgtcaaatgcagcgaatgatggttatcaagttgataatactccatctgttggtgcaattatgcaaagtacacctggaccatatggtcatgtagcatacgttgaacgtattaatggtgatggtagtattttaatttcagaaatgaattatgcaaatggtccatacaatatgaactatcgtactatcccagcttcagaagtatcttcatatgcatttatccactaa |
257. | atggcacgtattgctacaaaattgggctatcctgaaagcaatagtttcgtgactaatactgtaattgaatttgttttacataacgaagcatatcctcggttatataggattaaaactcgagatacgaacttaataaaaatttctcaagctaatgaaatctcacgtcaaattacaaatggcacgatgacgcttgaagaagctaagtatcaattagaggaaatatatgttgctaaaagagatagcagtctacccttcaaaggaattgccgcagcaattatcgctacgagcttcctctatctacagggaggtcgtctggttgatatcatcacagctgtattagctggaacgattggatacttagtagtagaaatattagatcgaaagctacacgcacaatttattccagaatttataggttctttggtaataggtattatttctgtaattggacatgcatttgttcctagcggagatttagctacaattatcattgccgcggtcatgcctattgtacctggagtacttattacaaatgctattcaagatttattcggaggacatatgttaatgtttacaacaaaatctttagaagctttagttactgcctttggtataggcgctggtgtaagttcaatattaattttagtc |
258. | atgacagaatttgacttatccactagagagggtcgttggaaacatttcggttctgttgaccctgtcaaaggtacgaaaccaactactaaaaatgaaatgaccgatttacaaagcactcacaaaaatttcttatttgaaatagaggaagtaggcattaaaaatttaacttatccagttttaattgatcagtatcaaacagctggtttatttagtttttcaacgagtttaaataaaaatgaaaaaggcattaatatgagtcgcatattagaaagcgttgaaaaacattatgataatggcattgaacttgaatttaacacactacatcaattgttgcgtacgctacaagataagatgaatcaaaatgctgcaggtgttgatgtgtcaggtaaatggttctttgatcgttatagtcctgttacacatattaaagctgtaggtcatgcagatgttacttatggtttagctattgaaaatcataccgttacacgtaaagaattaactattcaagccaaagtaacaacactatgtccttgctcaaaagaaattagtgaatattctgcacataatcaacgtggtatcgttacagttaaagcatatttagataaaaataatgacgtcatcgatgattataaaaataaaattttagacgctatggaagccaacgctagttctatcttatatccaatcttaaaacgtcctgatgaaaaacgagtaacagaacgtgcttatgaaaacccacgatttgttgaagatttaattcgactaattgcagcagacttagttgaatttgattggattgaagggttcgatattgaatgtcgtaatgaagagtctatccaccagcatgatgctttcgcacgtctgaaatatcgcaaa |
259. | gtgcaaaaaaaatatattactgccattattggaacaactgcccttagcgcattggcatcaactcatgcacaagctgcaacaacgcatacagtaaaaagtggagaatctgtatggtcaatttctcacaaatatgggattagtattgctaaattaaaatcacttaatggattgacttccaatttaatattccctaatcaagtattgaaagtatcaggctcatcttcaagagcaacgtcaacaaatagtggcacagtttatacagttaaagctggagattcattatcttctattgctgcaaaatacggtacaacttatcaaaaaatcatgcaacttaatgggttaaataactatcttattttccctggacaaaagttgaaagtttctggtaaagcgacgagttccagtcgtgcaaaagctagtgggtctagtggtcgtactgcaacatatactgttaagtatggagactcactatctgcaattgctagtaaatatgggacaacgtatcaaaaaattatgcaattaaatggattaactaatttctttatctatcctggacagaagttaaaagtgcctggaggtagttctagtagctcatcttctaataatactagatcaaacggtggctattattcaccaacttttaaccatcaaaacttgtatacttggggacaatgcacatggcacgtatttaatagacgtgctgaaataggaaaaggtatcagtacatactggtggaatgcaaataattgggacaatgcatcagctgctgatggatatactattgattatcgtcctacagtaggctcaattgcacaaactgacgctggttactatggtcacgtagcgtttgtagagcgcgtgaatagagatggaagtattttagtttcagaaatgaactggagtgcagctcctggaaatatgacatatagaacaattccagcttatcaagtgagaaattacaaatttattcatt |
260. | gtgaccaaaaaagcttttatttcttattctagaacaagtgatgaacatttaaatagagttgtgagaataggagaaagtttgagagttgatcatggaattgatgttattttagatgtatgggattgcactgagggagatgacttgaatttttttatggagtctatggttaatgacgagacgatagattttgttattatattaagcgattttcagtattttaatagagctaatgatagagaaggaggagttggaaaagaaagcacaataattacttctcaaatttatgataagcaaaaagatagtaagtttatacctgtctttttagatattctggataatggaaaaccatcattaccaactttttgtaatactagattcgctattgatatgacagacatcgaattagatatagagaaaatagaagagattgcaagaaaaatacacgataaacctttattcgaaaaaccaagacttggtaaagtaccagattataaccaaaatcaaaatgagttaaagaaagcaataaaaaaattaactttatctaaaagttataatgaaacgagaaattttgaagaagctttagacattatttataaaactttagaaaatatagaaaatagcgtagaggaatataataaagatgatttaatgactttaaaagaggtttttgatacttggaaagaatttattacgtatgcgctaaacaatgataacttttattttagggaattaatcatagagcattataataggtgcttaaagcttacggaagaagaatttgaaaatccaatgactaggatttttaattatttttcatttcttatactagtaagtgaatctttatcttcaggagcaaatgaatttttgaaagatttattgaatgctaaatttcattttagtagaagagaagcaaattattatatattaagtttatatccccaggtgttatccaagaaatattcatataatactaatgtcaaaaaaatgttagccgaaatgtactttgaagggaaggagttaaaaaaggttcaagatgcagatgtaattttatatacagaaagtcttatgaaaaaagatattcatagtgtatatgaaacgtggcatggggttctgttgtatagtagatggcctatgcttgagcaacaaactattaatattttaataaataaatttcgtagtaaaaaatatctagatcaatttgactttttatttggaagttcacaaagagaagtatttgaaaactatgataagattaaatccacacaagaaatacctactatttttaattttattgataaagaagaaattggcagctat |
261. | atgcactatctaaagaaagtaactatatacataagtttattaattttggtgagtggttgtggagacagcaaagaaacggaaatcaaacaaaactttaataaaatgttaaatgtgtatccaactaaaaatctagaagacttttatgataaagagggttatcgtgatgaagagtttgataaggatgacaaaggaacatggattattagatctgaaatgacaaaacagccaaaaggtaagattatgacttcaaaaggtatggtgttacatatgaatagaaatactagaagtacaactggttattacgttattaggaaaatttctgaagataataaaagtgaaattgatgatgaagaaaagaaatatcctataaagatggtaaataacaagataattccaactcaaaaaattaatgacaataaattgaagaatgaaatagaaaactttaagttctttgtacaatacggaagctttaaaaattcagatgattataaagaaggggatattgaatacaatcctaatgcaccaaattattctgcacaatatcatttaagtaatgatgactataatattaaacaattaagaaaaagatatgatattaaaacgaaaaaaactcctagattattaatgagaggcgctggagatccaaaaggatcttctgtaggttataaaaatcttgaatttacatttgttaagaataatgaggaaaatatttattttaccgatagtattaattttaatccaagcaagggtaaatcattg |
262. | gtgaaacattcgaaaaagttacttttatgcatcagttttttattaataacgttttttattggtggatgtggatttatgaataaagacgatggtaaagaaacggaaatcaaacaaaactttaataaaatgttaaacgtgtatcccactaaaaatctagaaaacttttatgataaagagggctatcgagatgaagagtttgataaggatgacaaaggaacatggatagttcattctaaaatggttattgaaccaaaaggcaaaaacatggaatctagagggatggttctctttatcaatcgcaatactagaacatcaaaaggctattttatagtcaatgaaatagaaaaggatagaaaaggaagacccattaataataaaaagaaatatcctgtaaaaatgaaaaataataaaattattccaaccaaaccaatatctaatgataaattaaaaaaagaaattgaaaactttaaattttttgtacaatatggcaattttaaagatattaaaaattataaagatggtgacatttcatacaatcctaatgtacctagttattctgcaaaatatcaattgagtaataatgaatataacgtacaacaattaagaaaaagatatgacatcccaactaaaaaagtacctaaactattgttgaaaggtgatggggatttaaaaggttcatccgtaggttctaaaaatctagaatttacttttatagaaaataaagaagagaatatctattttacagattctgtactatttagccctagcgaggataatgaatca |
263. | atgcgttatctcaagaaagtaacgatatacataagtttattaattttggtaagtggttgtggaaacggtaaagaaacggaaatcaaacaaaactttaataaaatgttagacatgtatccgactaaaaatctagaagacttttatgataaagaaggctatcgagatgaagagtttgataaaaaggataaagggacatggatagttggatctaccatgacaattgaaccaaaaggcaagtacatggaatctagaggtatgtttctatatattaatcgcaatactagaacaactaaaggttattattatgtgaggaaaacaacagatgacagtaaaggtagactaaaagatgatgaaaagagatatcctgtaaaaatggaacacaataaaattattccaacgaagccaatacctaatgacaaactaaaaaaagaaatagaaaacttcaaattttttgtacaatatggagattttaaaaacttaaaggattataaagatggtgacatttcatacaatcctaatgtacctagttattctgcaaaatatcaattgagtaataatgactataatgtaaaacaattacgaaaaagatatgatattcccaccaaccaagcccctaaattattgttaaaaggagatggtgacttaaaaggctcatctataggttccaaaagtttagaatttacttttatagaaaataaagaagagaatatctttttttcagatggtgtacaatttactcctagcgaggatagtgagtca |
264. | atgaaacattcaagcaaaataatagtatttgtaagtttcttaattttaacgatttttattggaggatgtggttttataaataaagaagatagcaaagaagctgaaatcaaacaaaactttaataaaacgttaagtatgtatccaactaaaaatctagaagacttttatgataaagagggctatcgtgatgaagagtttgacaaagatgacaaagggacatggattattaattctaaaatgattgttgaaccgaaaggggaagagatggaagcaagagggatggttttacgtataaatagaaatacgagaacagctaaaggtaactttattataaaacgaataacagaaaataataaaggaatacctgatgttaaagacaaaaaatatccagtaaaaatggaacacaataaaattattccaacaaaacaaattaaagataaaaaattaaaaaaagaaattgagaacttcaaattttttgtacaatatggaaattttaaaaacttaaaggattataaagacggagagatatcttacaatcctaatgtgccaagttactcagcgcaatatcaattgaacaattatgataataatgttaaacaactaagaaaaagatatgatattcccacgaatcaagctcctaaattattattgaaaggtacaggagatttaaaaggatcctctgtaggttataaacatcttgaatttacttttgtagaaaataaaaaggaaaatatttattttactgacagtataaactttaacccgagtagggggaat |
265. | atgcgttatctcaagaaagtaactatatacataagtttattaattttaacgatttttattggaggatgtggttttataaataaagaagatagcaaagaaacggaaatcaaacaaaactttaataagatgttaaacgtgtatcctactaaaaatctagaagacttttatgataaagaaggttttcgagatgaagaatttgataaaggagataaaggaacttggattattaggtctgaaatgacaaaacagccaaaaggtaaaattatgacctcaagaggtatggttctctatatcaatcgtaacactagaacagccaaagggtattttttaatagatgagataaaagatgataatagtggtagaccgatagagaatgaaaagaaataccctgtaaaaatgaaccataataagatctttccaacaaagccaatatctgatgataaattaaaaaaagaaattgaaaacttcaaattttttgtacaatatggagattttaaaaacttaaaggattataaagacggagagatatcttacaatcctaacgttcctagttactcagcgcaatatcaattgaacaataatgataataatgttaaacaattaagaaaaagatatgatattccaaccaatcaagcccctaaattattgttaaaaggggatggcgacttaaaaggatcatctgtaggttctaaaaatttagaatttacttttgtagaaaataaagaagagaatatattttttacagatgcagtacaattcactcctagcgaggatgatgaatca |
266. | atgaagacctataagccgtaccgacatcaattaaggcgttcgctatttgcctcaacgattttcccagtatttatggtgatgattattggtttaataagcttttatgctatttatatatgggtcgaacatcgcaccattcatcagcatacctatcaaactcaaaccgaattacaacgtatcgacaaacattttcatacgtttgttacgcagcaacaaaaacaatggcgtcatgttgatttatcacatccaactgatatcacaaagatgaaacgccaactattaaaacaagtccatcaacaacctgcgatattgtattacgatttaaaaggttcttcacaatctttcacaaacaattatgaacaattagacacaacaaagatgtatttaatatcaaaatatcgaattgattttaaagacgatacttatatccttaaaatatatatgtcaagcacaccactacttaaaaacattaagaaaaatagtggacaatctgcactcattgttgattcatatgatactgttttatatacaaatgacgaccgattctctatcggtcaaaaatatcaaccaccacagtttgggtttatgaacgagtctttaaaactcaattctcatcatgcgcatcttattatatataaagatattcatgaaaccattgaagatggaattgcattactagttgtcatgggtgttgttcttattctgcttgttatttttggatatataagcgctgatagaatggcaaagcgccaatctgaagatattgaagcgattgtccgaaaaattgatgatgctaaaaatcgacatcttggtagttacgaaccgttaaaaaaacatagtgagttagaggaaataaataattatatctatgacttgtttgaatcaaatgagcaattaatacaatctattgaacagaccgaacgtcgtttacgtgatatacaattaaaagaaattgagcgacaatttcaaccccatttcttattcaatacgatgcaaacgatacaatatttaattcctctttcacccaaagtagcacaaacagtcatacaacaactatcacaaatgctacgttattctctacgcacagcatcgcacacagtcaaattagcagaagaattaagctacattcagcagtatgttgctatacaaaatatccgcttcgatgatatgatacagctttacatcgatgctcctgaagatgtacaacatcaaacaattggtaagatgatgcttcaaccactcgtagaaaatgccatcaagcatggtcgtggtagtgaacctttaaagataacaattcgtatcagacttacgaagcgcaaattacatattctggttcatgataatggcatcggtatgtatccatcacatttagaacgcgtgcgccaatcacttcatcacgatgtttttgatacgacacacctaggtttaaatcatttacataatagagccatcattcaatatggaacatatgcacgtctgcacattttctcaagaagccatcaagggacattaatgtgttaccaaataccacttgtc |
267. | gtggatgatgtgacaaaatatggtccagttgatggagatccgattacgtcaacggaagaaattccgtttgataaaaaacgcgaatttgatccaaacttagcgccaggtacagagaaagtcgttcaaaaaggtgaaccaggaacaaaaacaattacaacaccaacaactaagaacccattaacaggagaaaaagttggcgaaggtgaaccaacagaaaaaataacaaaacaaccagtggatgagatcgttcattatggtggcgaagaaatcaagacaggccataaggatgaatttgatccgaacgcaccgaaaggtagtcaaacaacgcaaccaggtaagccaggagttaaaaatcctgatacaggcgaagtagtcacaccaccagtggatgatgtgacaaaatatggtccagttgatggagatccgattacgtcaacggaagaaattccgtttgataaaaaacgcgaatttgatccaaacttagcgccaggtacagagaaagtcgttcaaaaaggtgaaccaggaacaaaaacaattacaacgccaacaactaagaacccattaacaggggaaaaagttggtgaaggtgaaccaacagaaaaaataacaaaacaaccagtggatgagatcgttcattatggtggcgaagaaatcaagccaggccataaggatgaatttgatccaaacgcaccgaaaggtagccaagaggacgttccaggtaaaccaggagttaaaaatcctgatacaggcgaagtagtcacaccaccagtggatgatgtgacaaaatatggtccagttgatggagatycgattacgtcaacggaagaaattccgtttgataaaaaacgcgaatttgatccaaacttagcgccaggtacagagaaagtcgttcaaaaaggtgaaccaggaacaaaaacaattacaacaccaacaactaagaacccattaacaggggaaaaagttggcgaaggtgaaccaacagaaaaaataacaaaacaaccagtagatgaaatcacagaatatggtggcgaagaaatcaagccaggccataaggatgaatttgatccgaacgcaccgaaaggtagccaagaggacgttccaggtaaaccaggagttaaaaatcctgatacaggcgaagtagtcacaccaccagtggatgatgtgacaaaatatggtccagttgatggagatccgattacgtcaacggaagaaattccgtttgataaaaaacgcgaatttgatccaaacttagcgccaggtacagagaaagtcgttcaaaaaggtgaaccaggaacaaaaacaattacaacaccaacaactaagaacccattaacaggagaaaaagttggcgaaggtgaaccaacagaaaaaataacaaaacaaccagtggatgagatcgttcattatggtggcgaagaaatcaagacaggccataaggatgaatttgatccgaacgcaccgaaaggtagtcaaacaacgcaaccaggtaagccaggagttaaaaatcctgatacaggcgaagtagtcacaccaccagtggatgatgtgacaaaatatggtccagttgatggagatccgattacgtcaacggaagaaattccgtttgataaaaaacgcgaatttgatccaaacttagcgccaggtacagagaaagtcgttcaaaaaggtgaaccaggaacaaaaacaattacaacgccaacaactaagaacccattaacaggggaaaaagttggtgaaggtgaaccaacagaaaaaataacaaaacaaccagtggatgagatcgttcattatggtggcgaagaaatcaagccaggccataaggatgaatttgatccaaacgcaccgaaaggtagccaagaggacgttccaggtaaaccaggagttaaaaatcctgatacaggcgaagtagtcacaccaccagtggatgatgtgacaaaatatggtccagttgatggagattcgattacgtcaacggaagaaattccgtttgataaaaaacgcgaatttgatccaaacttagcgccaggtacagagaaagtcgttcaaaaaggtgaaccaggaacaaaaacaattacaacgccaacaactaagaacccattaacaggagaaaaagttggcgaaggtgaaccaacagaaaaaataacaaaacaaccagtggatgagattgttcattatggtggtgaacaaataccacaaggtcataaagatgaatttgatccaaatgcacctgtagatagtaaaactgaagttccaggtaaaccaggagttaaaaatcctgatacaggtgaagttgttaccccaccagtggatgatgtgacaaaatatggtccagttgatggagattcgattacgtcaacggaagaaattccgtttgataaaaaacgcgaatttgatccaaacttagcgccaggtacagagaaagtcgttcaaaaaggtgaaccaggaacaaaaacaattacaacgccaacaactaagaacccattaacaggagaaaaagttggcgaaggtaaatcaacagaaaaagtcactaaacaacctgttgacgaaattgttgagtatggtccaacaaaagcagaaccaggtaaaccagcggaaccaggtaaaccagcggaaccaggtaaaccagcggaaccaggtacgccagcagaaccaggtaaaccagcggaaccaggtacgccagcagaaccaggtaaaccagcggaaccaggtaaaccagcggaaccaggtaaaccagcggaaccaggtaaaccagcggaaccaggtacgccagcagaaccaggtacgccagcagaaccaggtaaaccagcggaaccaggtacgccagcagaaccaggtaaaccagcggaaccaggtacgccagcagaaccaggtaaaccagcggaatcaggtaaaccagtggaaccaggtacgccagcacaatcaggtgcaacagaacaaccaaatagatcaatgcattcaacagataataaaaatcaattacctgatacaggtgaaaatcgtcaagctaatgagggaactttagtcggatctctattagcaattgtcggatcattgttcatatttggtcgtcgtaaaaaaggtaatgaaaaat |
268. | mtkkekdykksleqqktrvkiyksgkswvkasineiellktmglpflskneiqenvtektkghklkksaakttalvggaftfnmlnnhqafaasetpitseissnsetvanqnsttiknsqketvnstslesnhsnstnkqmssevtntaqssekagisqqssetsnqssklntyastdhvesttinndntaqqdqnkssnvtskstqsntssseknissnltqsietkatdslatseartstnqisnltststsnqssptsfanlrtfsrftvlntmaaptttsttttssltsnsvvvnkdnfnehmnlsgsatydpktgiatltpdaysqkgaislntrldsnrsfrfigkvnlgnryegyspdgvaggdgigfafspgplgqigkegaavgigglnnafgfkldtyhntstprsdakakadprnvggggafgafvstdrngmatteestaaklnvqptdnsfqdfvidyngdtkvmtvtyagqtftrnltdwiknsggttfslsmtastggaknlqqvqfgtfeytesavakvryvdantgkdiippktiagevdgtvnidkqlnnfknlgysyvgtdalkapnytetsgtptlkltnssqtviykfkdvqgpqisvdsqtrevgktinpititttdnskdvltttvtglpsglsfdqttntiigtpsevgtttvtvnttdatgnvtskqftitiqdtispvvnvtpsqasevftpinpititatdnsgkvvthtvtglpqglkfdastnsivgtptqigtntitiestdasgnktttkinyevtrnsasdststsivnsvstsisnstslsdsvkasqslstkestskslsgslsastsnsasikasesastskklsesastsmsdsasikasesastskklsesaststsdsasikasesastskklsesastsmsdsvsikasesastskklsesaststsdsastqasesastskklsestststsdsaststsesdstsestslsdstsaslsestststsdsaststsesdsnststslseststslsestststsdsastsasvsdsnsastslreststslsdstststsdsaststsesdsdsastslsgssstsvsdstsastsesaststsisdsnststslseststslsestststsdsastsmsvsdsnsasislseststsvsdstststsesaststsesdsnsastslseststsvsdstststsdsaststsvsdsnsastslseststsisdstststsdsaststsvsessstskklsesastsmsdsasastsesnststslsgststslsgstststsesaststsvsdsnsastslseststslsdstststsdstsastsesdsnststsmseslstsvsdstststsdsaststsvsdsnsastslsdststsisdstsastsdsasesasesestsestsvsessstsvsdstststsesaststsesestsestsvsessstsvsdstststsesaststsesestsestslsgssstsvsdstststsesaststsvsdsnststslseststslsnstststsdsaststsvsdsnsastslsgslstnvsdstststsdsaststsesdsnsastslsgslstsisdstststsdsaststsesaststsvsesdsestsmsvsdsnststslsdststsvsdstrtstsdsastsksvsesnsastsvsgststsisdssststsmstsetftsqspinsesqfigdslsedtivtqskntnmlnktgkdydlqeqrgytdseqhnetqsnqadnhsnnldllhqnrlqdkvvkqptkgedgvvsngfivavaivlaifglakksrkddddqdgsk |
269. | mkktviastlavslgiagyglsgheahasettnvdkahlvdlaqhnpeelnakpvqagaydihfvdngyqynftsngsewswsyavagsdadytesssnqevsantqssntnvqavsaptssesrsyststtsysapshnysshsssvrlsngntagsvgsyaaaqmaartgvsastwehiiaresngqlharnasgaaglfqtmpgwgstgsvndqinaaykaykaqglsawgm |
270. | mnknkvivigstnvdkflnvkrfpkpgetlhinqaqkefgggkganqaiaasrlaadttfiskvgkdgnanfiledfkkagihtqyiltseseetgqafitvdeagqntilvygganmtlsatdvemsvdafigadfvvaqlevpfeaieqafkiarkqnittvlnpapaielpkslleltdiiipneteaelltgisinnesdmketatyfldlgisavlitlgeqgtycayqeqykmlpacnvkaidttaagdtfigaflselnkdlsnlesairlanqassltvqrkgaqasiptrkeveaeyn |
271. | malkkykpitngrrnmttldfaeitkttpeksllqplpkragrnnggkltvrhhggghkrqyrvidfkrnkdgiiakvdsiqydpnrsaniallvyadgekryiiapkglqvgqtvesgaeadikvgnalplqnipvgtvihnielkpgkggqlarsagassqvlgkegkyvlirlrsgevrmilstcratigqvgnlqhelvnvgkagrsrwkgvrptvrgsvmnpndhphgggegrapigrpspmspwgkptlgkktrrgkkssdklivrgrkkk |
272. | mkskftillftifsttvlvlviiynktqsqsyisthysnnkikttatlflhgyggsersetfmvkqalnknvtnevitarvssegkvyfdkklsedaanpivkvefkdnkngnfkenaywikevlsqlksqfgiqqfnfvghsmgnmsfafymknygddrhlpqlkkevniagvyngilnmnenvneiivdkqgkpsrmnaayrqllslhkiycgkeievlniygdledgshsdgrvsnsssqslqyllrgstksyqemkfkgakaqhsqlhenkdvaneiiqflwet |
273. | mkigidaggtlikivqehdnrryyrtelttniqkvidwlnneeietlkltggnagviadgihhspeifvefdasskgleilldeqqhqiehylfanvgtgtsfhyfdgkdqqrvggvgtgggmiqglgyllsnitdykeltnlaqngdrdaidlkvkhiykdteppipgdltaanfgnvlhhldnqftsanklasaigvvgevittmaitlareyktkhvvyigssfnnnqllrevvenytvlrgfkpyylengarsgalgalyl |
274. | mtlnnhfaytfeerptpklwlckpdgtrieriadfsklggtfkftnvntlhfdlplqvfsedtkqiernkvvdlvknkylidyryngyrdifviddikksandsdfitlnldsraselnkkaaneiellgstipqmmnkilsvyaplwklghvdgkiidvkreltgsnttvnalidnicslfdavaiynninrtisfyhkdnvgtnrglrvrensylksfedqfvskdivtrlypfgqsgltiqsvmpagssyiedfsyfmspfkrdnnrnvlqhsdymsdelchalldyqefyaskkdqagelskqysailkehsqedfrlnqlsatlqrlnervelvkpkseyidlgtkvknfkitvpkssyylimirndgsftrikfnnkqydipsgewlyiklktgkfndatkfekqleypleilsananlrvvytrssegdyeeedtktieekknlekykilvkdqekvvasierrlkafedqkasvirsmnaknflseklynerelyvfesvwteenhtdaqelyddavkqmkeqkkinrtitvdlvnfiqsldhkddwdklnvgdkvvfqnkifntkikayitemqldfqtnqvkitisdifdykdldtiiaeklaqttstssqvdfhkqqireqtgritdmtrliegewdankkrvmagnetvdigshgvkviskenpnefvimvggviamtrdngetfktgitpeginaemligkmivgetltfenesgtvkfdkdglyvnsknfhlvsndgeedyfdklkremsenakqqtdrmleeykkevsqtiseatdvrnivdnaadilqaafadgvitdvekrlisetlaqlekenrefedkinlalnhpyiteedtielnnsiveyssmyetlvisinesvsdkmitpqeseeinqniinfreeikdilslveeiiertknaqlqatleeakdyttrvrddikdelkdlnnsfkslnstveeslqdnifdaaeleaiktvvlvtkseyqditnryssmsantdlkseskldltksyktldtsfndfvkyidemtmdriadetekvnykkkydtlqknlsdymkkydncileiskkysndaadkvlgdftaiatelqndfqdvkdnwaefkqttlesfkdgivteaekarlrvqldmldresmdieeryksllanqytntdiknrltasrspylsvhaslrkvieqiiadgkvdesektlannslntynttltaysktiqealntlsqiissdvaskkveefngvittissdvdtikkqrdgavityyysgvptlsndpakswttndlkdlhikdmyldtksgyaytftksgtsyswkpltdqvivsslkqaknaqdtadnkrrvfvtqpippydqgdnwtqgsqgdiyvcgtsratgsfvssdwvkaskytddtvakqaakdledykvkmtkdfkdlndgvstfktevvkdfkdgivteaektrlrvqldildresqdieerynsifnsqyadtqvktsisnarstynnsltklrntiqtviedgkvtptekttanqtltaynnaltsysaaiqealnsmskviaqkeatsqvnqfneviknintnitdiqkqvdgaietfyysgvptltnipasywttaskreahlgdlyldtatgvayrflkkgttsptyywspisdqiitdalnraktaqdtadgkrrvfvntpvppydtgdmwtqgasgdilvcktpkakggiysisdwvkaskytddtvansavqqlneykrtnnldiadlkrktsdfektvvnafddrvisisesssikgqlallnhekdrltrqyeniirnsnlvgaektklstaysnintklsdlsttinsaivdnkivdaesksvtskfelykasvneyqiafdnalnsiireiassqakdrldewkrtefstdsdgiiervagakfdskwtdtwrntvnpaiqqvsnitygsenlllnsesrsdganttthsfiryyltrpletgktytlkasvlttderqsgqisvypyspngaretvnikdgkitytftaqtestqfliykdvagqsdvdlnvtiekailvegnkvtgwspapeetssalrdyntrissaetfieknkekisqiatksdvdaslskvatyetqynvssgtnyqiplqeyngsfftdnytyevvaknnslssnnvstaifvskgsnngyelveldnmsktganprfvldskgrpsistfspqsttqdisviytkylgsasainttkslieqtassielqvkkltaeteynnillnsdfssgwegwinvdpqysivdkntfgitlpdaitnknkkyntvkmtynkntnypsvfsnfisvgkgqevaigehltltcyayipssskgkltgniyiefagyyekdqksnpmiarheilpkdfeynkwfrmtastaipstnsegkkinyiraclrydgknqsvnnsaifyyalpqlergskptewslsrldvfsteqlaakialnpesvdiiarnidfntdsmkiynsngtlnisgdtltisnnnssneviinpkgftlkkdgvvkfkngldtsdysvqayepqfsswnnikatdpaakskynyrrhiepgmngyytintgvynfavqhkqllevnntknarvnrytylynkrylkiqmsassrgksklyiifktktgdttlhqeivssssmvypditidlqaklgyppnnlpdffelqagiaygennsidgffrirrmamtdtpnaev |
275. | mynvtqhatyktknkretavligvhaqtdrqfnfestmeeldalsqtcqlnvkgqitqnreqfdhkyyvgkgkideiksfiefhdidvvvtndelttaqsktlndnlgikiidrtqlileifalrarsregklqvelaqldyllprlhghgkslsrlgggigtrgpgetklemdrrhirtrmneikhqlktvvdhreryrnkreqnqvfqialvgytnagksswfnvlaneetyeknilfatldpktrqiqvnegfnliisdtvgflqklpttlvaafkstleeakgadvlmhvvdashseyrtqidtvnqiindldmdhipqvvifnkkdlcneqmdvpvsksahvfvssrdendkqkvknlviqeiknslspyeeivdsadadrlyflkghtlvtelifdetqasyrikgfkkl |
276. | mmiivmlilsyligafpsgliigklffkkdirqygsgntgatnsfrylgrpagfivtfldifkgfitvffplwfpvhadgvistfftnglivglfailghvypiylkfnggkavatsagvvlgvnpillliiaiiffsvlkifkyvslssiiaaiscvigsiiihdvillavsgivsiiliirhksnivrifkgeepkikwm |
277. | mmnhsealteqvfsfaselyaygvrevvispgsrstplalvfeahpniktwihpdersaaffalglikgsekpvailctsgtaaanytpaiaesqisrlplvvltsdrphelrsvgapqainqvnmfsnyvnfqfdlpiadgsehtidtinyqmqiasqylygphrgpihfnlpfrepltpdldrvdlltsvtktlphyqksisvddikdilqekngliivgdmqhqavdqiltystiydlpiladplsqlrkekhpnvittydllyraglnlevdyvirvgkpviskklnqwlkktdayqiivqnndqidvfptpphisyeisandffrslmeeplverkkwlqqwqsleqqarieisdylkhatdeaayvgsliqkltkedtlfvgnsmpirdvdnllfdseasvyanrgangidgvvstalgmaahknvtlligdlsfyhdmngllmaklnelhinivlvnnngggifsylpqkrsatkyferlfgtptglnfeytallydftfkrfdnltdfkyaelskmgshmyevitnrdenlhqhqnlyqklseivnvtl |
278. | makkfnyklpsmvaltlfgtaftahqanaaeqpqnqsnhknvlddqtalkqaekaksevtqsttnvsgtqtyqdptqvqpkqdtqsttydasldemstyneissnqkqqslstddanqnqtnsvtknqqeetndltqedktstdtnqlqetqsvakenekdlgananneqqdkkmtasqpsenqaietqtasndnesqqksqqvtseqnetatpkvsntnasgynfdyddedddsstdhlepislnnvnatskqttsykykepaqrvttntvkketasnqatidtkqftpfsataqprtvysvssqktsslpkytpkvnssinnyirkknmkaprieedytsyfpkygyrngvgrpegivvhdtandnstidgeiafmkrnytnafvhafvdgnriietaptdylswgagpygnqrfinveivhthdydsfarsmnnyadyaatqlqyynlkpdsaendgrgtvwthaaisnflggtdhadphqylrshnysyaelydliyekyliktkqvapwgttstkpsqpskpsggtnnkltvsanrgvaqikptnnglyttvydskghktdqvqktlsvtktatlgnnkfylvedynsgkkygwvkqgdvvyntakapvkvnqtynvkagstlytvpwgtpkqvaskvsgtgnqtfkatkqqqidkatylygtvngkagwiskyylttaskpsnptkpstnnqltvtnnsgvaqinaknsglyttvydtkgkttnqiqrtlsvtkaatlgdkkfylvgdyntgtnygwvkqdeviyntakspvkinqtynvkpgvklhtvpwgtynqvagtvsgkgdqtfkatkqqqidkatylygtvngksgwiskyyltapskvqalstqstpapkqvkpstqtvnqiaqvkannsgirasvydktaksgtkyanrtflinkqrtqgnntyvllqdgtsntplgwvnindvttqnigkgtqsigkysvkptnnglysiawgtknqqllapntlanqafnaskavyvgkdlylygtvnnrtgwiaakdliqnstdaqstpynytfvinnsksyfymdptkanryslkpyyeqtftvikqkningvkwyygqlldgkyvwikstdlvkekikyaytgmtlnnainiqsrlkykpqvqneplkwsnanysqiknamdtkrlandsslkyqflrldqpqylsaqalnkllkgkgvlenqgaafsqaarkyglneiylishalvetgngtsqlakggdvskgkfttktghkyhnvfgigafdnnalvdgikyaknagwtsvskaiiggakfignsyvkagqntlykmrwnpanpgthqyatdinwanvnaqvlkqfydkigevgkyfeiptyk |
279. | vafefrlpdigegihegeivkwfikagdtieeddvlaevqndksvveipspysgtveevlvdegtvavvgdvivkidapdaeemqfkghgddedskkeekeqespvqeeasstqsqektevdesktvkampsvrkyarengvnikavngsgkngritkedidaylnggsseegsntsaasestssdvvnasatgalvegdfpettekipamrkalakamvnskhtaphvtlmdeidvqelwdhrkkfkeiaaeqgtkltflpyvvkalvsalkkypalntsfneeagevvhkhywnigiaadtdkgllvpvvkhadrksifeisdeinelavkardgkltseemkgatctisnigsaggqwftpvinhpevailgigriaqkpivkdgeivaapvlalslsfdhrqidgatgqnamnhikrllnnpelllmeg |
280. | mnetdeisqiynkhrlpslsglakvsplvhrasiggvlnvaelnrikrlvqvqnqfktfynqmleedeevkypilhdkmnhlpiltdlfkeinetcdahdlfdhasytlqsirskisrtnqrirqnldrivknqgnqkklsdaivtvrndrnvipvkaeyrqdfngivhdqsasgqtlyiepnsvvemnnqisrlrndeavererilteltgfvsaeadalliaesvmgqidfliakaryartikgtkptfkedrtiylpnafhplldkdtvvantiefiddvetviitgpntggktvtlktlgliivmaqsglliptldgsqlsifenvycdigdeqsieqslstfsshmkniveilqdadqnslilfdelgagtdpsegaalamsildyvrrlgslvmatthtpelkaysynregvmnasvefdvetlsptykllmgvpgrsnafdiskklglslniinkaktmigtdeqeinamiesleqnskrvdqqrieldrlvreaqqthdalskqyqqyqnyetslmdeakekanqrvksatkeadeilkelrnlrdhkgaevkehelidkkkqlddqyevksikqhvqkkkydtihtgdevkvlsygqkgevlelvgdeeavvqmgiikmklpiedlektkkkkekptkmvtrqnrqtikteldlrgyryeealneldqyldqavlsnyeqvyiihgkgtgalqkgvqqhlkkhksvrqfrggmpseggfgvtvaelk |
281. | msffkrlkdkfsskneddiqkdldesvdsnvnsdsdsmdpndsdeqvkpkkkpkklseadfdedglisiedfeeieaqkigakfkagleksrqnfqeqlnnliaryrkvdedffealeemlitadvgfntvmkltdelrteaqrrniqetedlrevivekiveiyhqeddhseamnieagrlnvilmvgvngvgktttigklayryqqegkkvmlaagdtfragaiqqlnvwgervgvevvsqnegsdpaqvvydainaaknkdvdiiicdtagrlqnksnlmqeldkmkrvinraipdapheallcldattgqnalsqarsfkevtnvsgivltkldgtakggivlairnelhipvkyvglgekmddlqpfspegyvyglfadmieqnedipeeisrnssveseegn |
282. | mkrnwwkeavayqvyprsfndsngdgigdlpgliekldylenlgidviwlspmypspnddngydisdykgimsefgtmndfdgllssihqrgmklildlvvnhtsdehpwfieskssktnakrdwyiwadpkpdgsepnnwesifngstwefdestkqyyfhlfskkqpdlnwenpdvrqavfemmnwwfekgidgfrvdaithikknfeagdlpvpdgkkfapafdvdmnqpgiqewlqemkdkslsrydimtvgeangvtpndaeewvgeengkfnmifqfehlglwstgdtkfdvksykqvlnrwqkqlenvgwnalfienhdqprrvstwgddknywyesatshatayflqqgtpfiyqgqeigmtnypfesiesfndvavkteyqivkkeggdvnqlldkykmenrdnartpmqwnnsinagfttgkpwfhvnpnyteinvkqqlndkfsilsyykaliqlkksdliytygkfnmvdaenkqvfaytrtfknntvlivanltnevselnlpfeldissvdiklhnyhlndinldhikpyesfvvei |
283. | lshrklfpsifhlyqqdnldehiaiigigrrdynneqfrdqvkasiqtyvkdtdridefmthvfyhktdvsdkesyqsllgfserldsefalggnrlfylamapqffgvisdylkssgltqttgfkrlviekpfgsdlksaeslnnqirrsfkeeeiyridhylgkdmvqnievlrfanamfeplwnnkyisniqvtssevlgvedrggyyessgalkdmvqnhmlqmvallameapislnsediraekvkvlkslrglkpeevkknfvrgqydqgnidgkqvksyreedrvakdsvtptfvsgkltidnfrwagvpfyirtgkrmksktiqvvvefkevpmnlyyetdnlldsnllviniqpnegislhlnakkniggidtepvqlsyamsaqdkmntvdayenllfdclkgdatnftnweelkstwkfvdaiqdqwtmvepcfpnyeagtngplesdlllsrdgnhwwddih |
284. | mikknkeelndmeylvtqengteppfqneywnhfekgiyvdklsgkplftsedkfesncgwpsfskalnddeivelvdksfgmirtevrsekanshlghvfndgpkekgglrycinsaaiqfipydkleelgygdlikhfkk |
285. | lkklafaitaasgaaavlshhdaeastqhkvqsgeslwtiaqqyntsvesikqnnnlsnnmvfpgqvinvggsasqntssntssssasshtvvageslniiankygvsvdalmqanhlngylimpnqiltipnggsgsgsggtatqtsgnytspsfnnqnlytegqctwyvfdkrsqagkpistywsdakywasnaandgyqvdntpsvgaimqstpgpyghvayveringdasilisemnyangpynmnyrtipasevssyafih |
286. | mariatklgypesnsfvtntviefvlhneayprlyriktrdtnlikisqaneisrqitngtmtleeakyqleeiyvakrdsslpfkgiaaaiiatsflylqggrlvdiitavlagtigylvveildrklhaqfipefigslvigiisvighafvpsgdlatiiiaavmpivpgvlitnaiqdlfgghmlmfttkslealvtafgigagvssililv |
287. | mtefdlstregrwkhfgsvdpvkgtkpttknemtdlqsthknflfeieevgiknltypvlidqyqtaglfsfstslnknekginmsrilesvekhydngielefntlhqllrtlqdkmnqnaagvdvsgkwffdryspvthikavghadvtyglaienhtvtrkeltiqakvttlcpcskeiseysahnqrgivtvkayldknndviddyknkildameanassilypilkrpdekrvterayenprfvedlirliaadlvefdwiegfdiecrneesihqhdafarlkyrk |
288. | vqkkyitaiigttalsalasthaqaatthtvksgesvwsishkygisiaklkslngltsnlifpnqvlkvsgsssratstnsgtvytvkagdslssiaakygttyqkimqlnglnnylifpgqklkvsgkatsssrakasgssgrtatytvkygdslsaiaskygttyqkimqlngltnffiypgqklkvpggsssssssnntrsnggyysptfnhqnlytwgqctwhvfnrraeigkgistywwnannwdnasaadgytidyrptvgsiaqtdagyyghvafvervnsdgsilvsemnwsaapgnmtyrtipayqvrnykfih |
289. | vtkkafisysrtsdehlnrvvrigeslrvdhgidvildvwdctegddinffmesmvndetidfviilsdfqyfnrandreggvgkestiitsqivdkqkdskfipvfldildngkpslptfcntrfaidmtdieldiekieeiarkihdkplfekprlgkvpdynqnqnelkkaikkltlsksynetrnfeealdiiyktleniensveeynkddlmtlkevfdtwkefityalnndnfyfreliiehynrclklteeefenpmtrifnyfsflilvseslssganeflkdllnakfhfsrreanyyilslypqvlskkysyntnvkkmlaemyfegkelkkvqdadvilyteslmkkdihsvyetwhgvllysrwpmleqqtinilinkfrskkyldqfdflfgssqrevfenydkikstqeiptifnfidkeeigsy |
290. | mhvlkkvtiyisllilvsgcgdsketeikqnfnkmlnvyptknledfydkegyrdeefdkddkgtwiirsemtkqpkgkimtskgmvlhmnrntrsttgyyvirkisednkseiddeekkypikmvnnkiiptqkindnklkneienfkffvqygsfknsddykegdieynpnapnysaqyhlsnddynikqlrkrydiktkktprllmrgagdpkgssvgyknleftfvknneeniyftdsinfnpskgksl |
291. | vkhskklllcisfllitffiggcgfmnkddgketeikqnfnkmlnvyptknlenfydkegyrdeefdkddkgtwivhskmviepkgknmesrgmvlfinrntrtskgyfivneiekdrkgrpinnkkkypvkmknnkiiptkpisndklkkeienfkffvqygnfkdiknykdgdisynpnvpsysakyqlsnneynvqqlrkrydiptkkvpklllkgdgdlkgssvgsknleftfienkeeniyftdsvlfspsednes |
292. | mrylkkvtiyisllilvsgcgngketeikqnfnkmldmyptknledfydkegyrdeefdkkdkgtwivgstmtiepkgkymesrgmflyinrntrttkgyyyvrkttddskgrlkddekrypvkmehnkiiptkpipndklkkeienfkffvqygdfknlkdykdgdisynpnvpsysakyqlsnndynvkqlrkrydiptnqapklllkgdgdlkgssigsksleftfienkeeniffsdgvqftpsedses |
293. | mkhsskiivfvsfliltifiggcgfinkedskeaeikgmfnktlsmyptknledfydkegyrdeefdkddkgtwiinskmivepkgeemeargmvlrinrntrtakgnfiikritennkgipdvkdkkypvkmehnkiiptkqikdkklkkeienfkffvqygnfknlkdykdgeisynpnvpsysaqyqlnnydnnvkqlrkrydiptnqapklllkgtgdlkgssvgykhleftfvenkkeniyftdsinfnpsrgn |
294. | mrylkkvtiyislliltifiggcgfinkedsketeikqnfnkmlnvyptknledfydkegfrdeefdkgdkgtwiirsemtkqpkgkimtsrgmvlyinrntrtakgyflideikddnsgrpienekkypvkmnhnkifptkpisddklkkeienfkffvqygdfknlkdykdgeisynpnvpsysaqyqlnnndnnvkqlrkrydiptnqapklllkgdgdlkgssvgsknleftfvenkeenifftdavqftpseddes |
295. | mktykpyrhqlrrslfastifpvfmvmiiglisfyaiyiwvehrtihqhtyqtqtelqridkhfhtfvtqqqkqwrhvdlshptditkmkrqllkqvhqqpailyydlkgssqsftnnyeqldttkmyliskyridfkddtyilkiymsstpllknikknsgqsalivdsydtvlytnddrfsigqkyqppqfgfmneslklnshhahliiykdihetiedgiallvvmgvvlillvifgyisadrmakrqsedieaivrkiddaknrhlgsyeplkkhseleeinnyiydlfesneqliqsieqterrlrdiqlkeierqfqphflfntmqtiqyliplspkvaqtviqqlsqmlryslrtashtvklaeelsyiqqyvaiqnirfddmiqlyidapedyqhqtigkmmlqplvenaikhgrgseplkitirirltkrklhilvhdngigmspshlervrqslhhdvfdtthlglnhlhnraiiqygtyarlhifsrshqgtlmcyqiplv |
296. | vddvtkygpvdgdpitsteeipfdkkrefdpnlapgtekvvqkgepgtktittpttknpltgekvgegeptekitkqpvdeivhyggeeiktghkdefdpnapkgsqttqpgkpgvknpdtgevtppvddvtkygpvdgdpitsteeipfdkkrefdpnlapgtekvvqkgeppgtktittpttknpltgekvgegeptekitkqpvdeivhyggeeikqghkdefdpnapkgsqedvpgkpgvknpdtgevvtppvddvtkygpvdgdxitsteeipfdkkrefdpnlapgtekvvqkgepgtktittpttknpltgekvgegeptekitkqpvdeiteyggeeikqghkdefdpnapkgsqedvpgkpgvknpdtgevvtppvddvtkygpvdgdpitsteeipfdkkrefdpnlapgtekvvqkgepgtktittpttknpltgekvgegeptekitkqpvdeivhyggeeiktghkdefdpnapkgsqttqpgkpgvknpdtgevvtppvddvtkygpvdgdpitsteeipfdkkrefdpnlapgtekvvqkgepgtktittpttknpltgekvgegeptekitkqpvdeivhyggeeikpghkdefdpnapkgsqedvpgkppgvknpdtgevvtppvdvtkygpvdgdsitsteeipfdkkrefdpnlapgtekvvqkgepgtktittpttknpltgekvgegeptekitkqpvdeivhyggeqipqghkdefdpnapvdsktevpgkpgvknpdtgevvtppvddvtkygpvdgdsitsteeipfdkkrefdpnlapgtekvvqkgepgtktittpttknpltgekvgegkstekvtkqpvdeiveygptkaepgkpaepgkpaepgkpaepgtpaepgkpaepgtpaepgkpaepgkpaepgkpaepgkpaepgtpaepgtpaepgkpaepgtpaepgkpaepgtpaepgkpaesgkpvepgtpaqsgapeqpnrsmnstdnknqlpdtgenrqanegtlvgsllaivgslfifgrrkkgnek |
297. | atgaataaacagatttttgtcttatattttaatattttcttgatttttttaggtatcggtttagtaataccagtcttgcctgtttatttaaaagatttgggattaactggtagtgatttaggattactagttgctgcttttgcgttatctcaaatgattatatcgccgtttggtggtacgctagctgacaaattagggaagaaattaattatatgtataggattaattttgttttcagtgtcagaatttatgtttgcagttggccacaatttttcggtattgatgttatcgagagtgattggtggtatgagtgctggtatggtaatgcctggtgtgacaggtttaatagctgacatttcaccaagccatcaaaaagcaaaaaactttggctacatgtcagcgattatcaattctggattcattttaggaccagggattggtggatttatggcagaagtttcacatcgtatgccattttactttgcaggagcattaggtattctagcatttataatgtcaattgtattgattcacgatccgaaaaagtctacgacaagtggtttccaaaagttagagccacaattgctaacgaaaattaactggaaagtgtttattacaccagttattttaacacttgtattatcgtttggtttatctgcatttgaaacattgtattcactatacacagctgacaaggtaaattattcacctaaagatatttcgattgctattacgggtggcggtatatttggggcacttttccaaatctatttcttcgataaatttatgaagtatttctcagagttaacatttatagcttggtcattattatattcagttgttgtcttaatattattagtttttgctaatgactattggtcaataatgttaatcagttttgttgtcttcataggttttgatatgatacgaccagccattacaaattatttttctaatattgctggagaaaggcaaggctttgcaggcggattgaactcgacattcactagtatgggtaatttcataggtcctttaatcgcaggtgcgttatttgatgtacacattgaagcaccaatttatatggctataggtgtttcattagcaggtgttgttattgttttaattgaaaagcaacatagagcaaaattgaaagaacaaaatatg |
298. | atgctattttatttatttcattttacaatcagctttatatcaacagtacttttctctatcattttcaatgcacccaaacgcctcttagtagcatgtggatttgtgggtgccattgcatggacgatttaccaattaacggtagatttagagtttggaaaagttggcgcttcatttttgggaagcttaattttaggcttaatgagtcatactatgagtcgcagatataaacgaccggtaattatattcatagtgccaggcattataccattagtacctggtggtgcagcttatcaagcgactcgttttttagtatcaaatgattatacaagtgctgtaaatacatttttagaagttacactgatttcaggtgcgattgctttcggtatattagtttctgaaattctatattacctatacacacgtatcaaacaactgtatggtaaaatcaaaggtaagacatataaaaaatcttacaacatgaataatagagtt |
299. | atgataaatgcagtagtaatagcagtaattttaatgattatgctatgtttatgtcgattaaacgtagttataagcttatttatcagtgcgctagttggtggcttaatttcaggcatgagcattgaaaaagttataaatgtatttgggaaaaatatagtcgatggtgctgaggtagcattaagctatgctttattaggtggatttgcagcattaatttcatacagtggtatcacagactatttagtaggaaaaattataaatgcaattcacgctgaaaatagtcgatggtcaagagttaaagtcaaagtgacaataatcattgcattattagctatgagtatcatgagtcaaaacttaattcctgtacatattgcattcattccaattgtcatcccaccattgttaagtctgtttaatgacttaaaaatagatagacgtttaatcggtttgattatcggttttggtttatgtttcccgtatgtgttattaccatatggattcggtcaaattttccagcaaattattcaaagtggctttgcaaaggcaaatcacccaattgagtttaatatgatttggaaagcaatgcttattccttcaatggggtatattgttggcttacttatcggtttatatgtatatcgtaaaccacgtgaatatgaaacacgtaaaatttcagatagtgacaatgttacagagttaaaaccatatatcttaatagtaacaattgtagcaatactagctacatttttagtacaaacatttacagattcaatgatttttggtgcactggcaggggtactcgtattctttatttcacgtgcatataattggtatgaattagatgctaagtttgttgaaggtattaaaattatggcttatattggtgtagttattttaacagcaaatggatttgctggtgtaatgaatgctactggtgatatagatgaattagttaaaactttaacaagtattactggtgataataaattatttagcattatcatgatgtatgtgataggtttaattgtcactttaggtattggatcatcatttgcaacaattcctattatcgcatcattattcattccttttggagcgtcaattggactagatacaatggcattaatcgcattgattggaacagcgagtgcattaggtgactcaggttcgcctgcaagtgattcaacattaggaccaactgcgggattaaatgttgatggccaacatgatcatatacgtgatacatgtgtaccaaacttcttgttttataatattcctttaatgattttcggtactattgctgctatggtacta |
300. | atgaatcataatgttattatcgttattgcattaatcatagttgtcatttctatgttagctatgctcattcgcgttgtgctaggcccatcacttgccgatcgtgttgtcgcattagatgcgattggtcttcaattaatggcagttatagcattattcagtattttattaaatattaaatacatgattgtcgttattatgatgattggtatattagcttttttaggtactgcagtattctctaaatttatggacaaaggtaaggtgattgaacatgatcaaaatcatactgat |
301. | gtgaataggaatatcgttaaactagttgtgttcatgctaattttagttgtagcagtagcgggttgtggtcaaaaagatactgaagagaaaactgaaatgacgacaataaaagatgaattaggaactgaaaaaattaagaaaaatcctaaacgtgttgttgtattagaatatagttttgctgattatttagcagcattagatatgaaacctgttggtattgcagatgatggcagcactaaaaatataacaaagtcagtaagagataagattggggcatatgaatcggttggatctagaccgcaaccgaatatggaagtgataagtaaattaaaaccggatttgatcattgcagatgttagcagacataagaaaatcaaatcagaattgagcaaaattgctccgacaatcatgttagttagcggtacgggagattataatgcaaatattgaagcatttaaaacagtcgctaaagcagtaggcaaagagaaagaaggcgagaagcgtctggaaaagcatgataaaatattagcggagattagaaagaaaattgaacagagtacgttaaaatctgcatttgcattcggtatctcaagagcaggtatgtttattaataatgaagatacatttatgggacaattcttaattaaaatgggtattcaacctgaagtcacaaaagacaaaactacgcatgttggtgaacgcaagggtggtccttatatatatttaaataatgaagaacttgccaatatcaatccaaaagttatgattttagccactgacggaaaaacggacaaaaatagaacgaaattcattgatcctgcagtttggaaatcattaaaagctgtgaaagataacaaagtttatgacgttgaccgaaataagtggttgaaatcaagggggattatcgcaagtgaaagtatggcagaagatttagaaaaaattgcagaaaaagcaaaa |
302. | atgactggagaacaatttactcaaattaaacgtccagtaagtagattaactgaaaaagttctaggttggttatgttgggtgatgttattagtgcttactgtcattacgatgtttatagcacttgtttcattcagtaataacacatcgattgctaatcttgaaaatacattaaacaataatgcatttatccagcaattattagctggaaatggctataatacaacacaatttgtaatatggttacaaaatggtatatgggctattatcgtttactttattgtttgtttgttgatttcatttttagctctcatatctatgaatataagaatcttgtcaggtttcttattcttaatatcagcaattgtaacgattcctttagttttacttatcgttactttaatcattccgatattattctttattattgcgatgatgctatttataagaaaagataaagttgaaatggttgcgccacaatattatgaagagtataacggaccgatttatgattatcgtgaacctgtgtatgagcgcccccaaccgaaagatgattattatgatgtgcctaaatatgaaaaagaattggataaatcaaatactgtatatgatcaagaacaggaaagagataaatatgatcaatttcctaaacgtgcagttgaaagtgaatataatcatgatgagcgcactgaggaagaaccatcagtattatccagacaggctaaatacaaacaaaaaagtactgaagaactaggtattgaagatgatggttattatgcagaacctgaagttgatccaaaagaattgaaagcacaacaaaagcgagaaaaagctgaaattaaagctaagaaaaaagaaaaacgtaaagcttataaccaacgaatgaaagaacgtaggaaaaatcaacctagcgcagttagtcaacgtcgaatgaattttgaagagcgacgtcaaatttacaacaatgatatttctgaagaacgcaattcaagtgaagttaaggacaaaaaagagcaagaa |
303. | gtggaaaatacaattaatgaaagtgaaaagaaaaaacgatttaaattaaaaatgccaggtgcatttatgattttattcattttaacggttgttgcagttatagcaacatgggttattcctgctggtgcatattctaaactttcttacgaaccttcatcccaagaactaaagatagttaaccctcataaccaagtgaaaaaggttccgggtacgcaacaggaactagacaaaatgggggttaaaattaagattgaacaatttaaatcaggtgcaattaataagccggtatcaattccgaatacttatgaaagattaaagcaacatccagctggaccagaacaaataacaagtagcatggttgaaggtacgatagaagcggtcgatatcatggtattcattcttgtactagggggacttattggcgtagttcaagccagtggttcttttgaatcgggattgttagctttaacgaagaaaacaaaagggcatgaatttatgctaattgtgtttgtatcaatactaatgattatcggcgggacattatgtggtattgaagaagaagctgtagcattttatccgattttagtccctatatttatagcgttaggatacgattctatcgtttcagttggtgccatattccttgccagctctgtcggtagtacattttcaactattaacccgttctcggttgtaattgcctctaatgccgctggtacaacttttacggatggcttgtattggagaataggtgcttgtatt巾cggtgcgatttttgttattagttatttatattggtactgtaaaaaaattaaaaacgatcctaaagcgtcatattcttatgaagacaaagatgcttttgaacagcaatggtctgtattaaaagatgacgatagtgcccattttactttgcgtaagaagataatccttacattatttgtactaccatttccaattatggtatggggagttatgacgcaaggttggtggttcccagttatggcttcagcatttttaatatttacaattataataatgtttattgctgggacaggtaaatctggattgggagaaaaaggaactgtagatgcatttgtcaatggtgcatcaagtttagtaggtgtatctttaattattggtttagctcgaggtattaatttagtgttgaatgaaggtatgatttcagatacaatcttacacttttcatcatctttagttcaacatatgagtggaccattatttatcatcgtattactatttattttcttctgtttaggttttatcgtgccatcatcttctggcttagcggtattatcaatgcctatctttgcaccactagctgatacagtaggtataccaagattcgtcatcgttacgacatatcaatttggtcaatatgcgatgttattcttagcgccgactggacttgttatggccacactacaaatgttaaacatgcgatattcacattggttccgatttgtatggccggtagttgcttttgtattgattttcggtggcggagtactaattacgcaagtactaatttattca |
304. | atgagcttttttaaacgcttaaaagataagtttgcaacaaataaagaaaatgaagaagttaaatccttaacagaagaacaaggtcaagacaaattagaagatacacattctgaaggttcaacgcaggacgcaaatgatttagcagaaaatgctgaagtgaaaaagaagccacgcaagttgagtgaagcggattttgatgacgatggcttaatatcaattgaagattttgaagaaattgaagctcaaaaaatgggtgctaaatttaaagcaggactcgaaaaatctcgtcaaaatttccaagaacaattaaataatttgatagcgagatatcgtaaagtagatgaagacttttttgaagctttagaagaaatgttaatcactgcagacgtcggttttaatacagtgatgacgttaactgaagaattacgtatggaagcacaacgacgtaatattcaagatactgaagatttgcgtgaagtcattgttgaaaaaatcgtagagatttaccatcaagaagatgataattcagaagctatgaacttagaagatggtcgtttaaatgtcattttaatggttggtgtgaatggtgttggtaaaacaacaacaattggaaaattagcttaccgatataaaatggaaggtaaaaaagtaatgttagctgcgggcgatacttttagagcgggtgctattgatcaattgaaagtttggggcgaacgtgttggtgtagacgtaattagccaaagtgaaggttctgatccagctgctgttatgtatgatgcgattaatgccgctaaaaacaaaggtgttgatattttaatctgtgataccgctggacgtttacaaaataaaacaaatctaatgcaagaattagaaaaagttaagcgtgtaattaatcgagcagtgccagatgcgcctcatgaagcattactatgtttagatgctacaactggtcagaatgcgttgtcacaagctagaaactttaaagaagtaacaaatgttacaggtattgtattaacgaaattagatggtacagccaaaggtggtatcgtattagccattcgtaatgaattgcacatcccagttaaatatgtaggtttaggtgagcaattagatgacttacaaccatttaaccctgaaagttatgtctacggcttattcgctgatatgattgaacaaaatgaagaaataacaacagttgaaaatgatcaaattgtaacagaagaaaaggacgataatcatgggtcaaaa |
305. | gtgttaaaaaagtggctaaattcaaacgtcaaacaattctttgttataactttcattagtgtaatattaacgcttattttattttctactcatatctatgattatattgtgaatggtactgtttttagcggggctggagatggattccgtcaaatgatgccatttcaaatgtatttgtatgaacatctacgtagtttttctagtttatatgatgcatcgtttggattaggtggcgattatatgaaaggactatcatattattattcgctgtcacctttaatgtggctaaattttctattcattaaaataggagaaacggttggtatatttaatccgacgacaatacatttttggccgacaaaccaacttattatggctatgatacgagctatcataacatttgtcgtgaccttctacttatttaaaatattacactttaaacgctcagcaaatatgatcgctacgattttatacggcatgtcaactgtcgttatatactttaattttacttggtcattttatggaaatttattatatttattgccattatcgattcttggtttggaaagatattttcaacaacgcaaaatcggtattttcattgttgcgatagccttaacactatttagcaatttttatttcagttattatcaagctattattataggttgctactatttatatcgactcattttcacttacaaatatgacattgtctctagaacacaaaaattaatttgcgtcatatctgctacagttttgagtgtgttatcaagtgtatttggtttattcactggcatttctgcgtttttggaaaatgacagaaagcaaaatcccaatgttgatataccgtttttgacaccacttgattatcattattttttctttagcgatggattttatattacgatttcaattcttactatcgttgcattattgtcattcaaactgtatcgtttttacttttatagacttttcgcaatagtaacatggatattatttataggttcattatcacagtatttcgacagtgcttttaatggtttttcatttccagaaaggcgttgggtgtatatcttagcactatcatcaagtgctctttgcggattgtttattcaacatttatcaacattaaatatgaaatattatttaatcagaacaatacccgtatgcatcatcgcaatactttatgtattactatcaccgacacacccacttgcacttatagtaggtattatcctgctaatagtgcttgccgttattttaaaatttagtttatggcgttataaaaaattaaccgttgcaatattagtattaatcgttatgattcaacaaatcgtcattttagataacaacaaaaacatggcaatcaaaccttatcaacaatcattatcaacgttgaaacaacatgattaccatagtaactatgtaaaccagcttataaaaaagataaatcaaaatgcaacaggctcatttaatcgcattgattatatgtcagactatgcattaaattcaccatttatatatcattataatggcatttcattatattctagtatttttaatggagacattttaaaatattatgacaagacactccaaattaatatgccaatcgataaaaacagcacttatagattacttggcaatcgtcaaaatttactatcactttggaatgttaatgatcgaattagagtgaatcatgatgacaacttaccatatggatttaaaattaagtctgaacacaaagacaataaagttcgttggattcattctaaaaataccatccattatccaagtgcacatattacaaataaggtcttttccaataaagaattaaaatctccattagataaagaacaagcaatgttgcaagggattgtttctaacaatattaaagatgttaatacacattttaaagccaataaaaatttactatcagattcaacaattaaattaaatagtgcagcctggcaatctcctacaaaacatttattacaagttaaacaaaataatggtggtctaactgtacagttgccaaaatcagtttctaatcaatttaaagatttgtattttgaaatggatttagaattactttcgccggataaagctcatgatgttaaagtgaatgaatatacacaagaaagaaataaactcacttataaatatcgacgcgttgtaacacccgtaacgatacgcattaaagctccagatagaattagattatcattgcctaaaggtaagtatcgagtaaatttaaaagggatatacggcgaagattataccacgcttaaagacgcttcaaattcattagaagctgtcaaagttagtaagacaaagcatggttatactattactaaaaataaaaattcatctgggtatattgttttgccaacagcatataatcaaggtatgaaagcgacatcaggtgatcaaagtcttaaagttgaacaagtaaatggtgttatgaccggcattaaagcacctaaaaatataacaaagattcaattgagctataccccaccatactattatttacttataacaattactatatttggcattatatgtagtattattttcacgagatgggcaagacaaaaa |
306. | gtgcgtcaattggcacaagcaaaaaagaaatcgacagctaagaaaaaaacaacatcaaaaaaaagaacaaattcgaggaaaaagaagaatgataatccgatacgttatgtcatagctattttagtagttgtattaatggtgttgggtgttttccaattaggaataataggtcgtctaattgacagcttctttaattatttatttgggtacagtagatatttaacatatattttagtactcttagcaactggttttattacatactctaaacgtattcctaaaactagacgaacggctggttcgattgtattgcaaattgcattgctatttgtatcacagttagtttttcattttaatagtggtatcaaagctgaaagagaacctgtactttcttatgtgtatcagtcataccaacacagtcatttcccaaattttggtggcggtgtattaggcttttatttattagagttaagcgtacctttaatttcattatttggtgtatgtattattactattttattattatgctcaagtgttattttattaacaaaccatcaacatcgtgaagttgcaaaagttgcactggaaaatataaaagcttggtttggttcatttaatgaaaaaatgtcggaaagaaaccaagaaaaacaattgaagcgtgaagaaaaagcaagacttaaagaagaacaaaaggcacgtcaaaatgaacagccacaaataaaagatgtgagtgattttacggaagtgcctcaagaaagagatattccaatttatgggcatactgaaaatgaaagtaaaagccagagtcaaccaagtcgaaaaaaacgagtgtttgatgcagagaatagttcgaataacatcgtaaatcatcatcaagcagatcagcaagaacaattaacagaacaaactcataacagtgttgaaagtgaaaacactattgaagaagctggtgaagttacgaatgtatcgtatgttgttccaccgttaactttacttaatcaacctgcaaaacaaaaagcaacatctaaagctgaagtgcaacgtaaaggacaagtactagagaatacattaaaagattttggggtaaatgcaaaagtgacacaaattaaaattggtcctgcagtaactcaatatgaaattcaaccagctcaaggggttaaagtgagtaaaattgtaaacttgcataatgatattgcattagctttagcagcaaaagatgttagaatcgaagcgccaatacctggtcgttctgcagtaggtattgaagtgccaaatgagaaaatttcattagtttcactaaaagaagttttagatgaaaaattcccgtctaataataaactagaagttggattaggaagagatatatcaggtgatccaattactgttccactaaatgaaatgccacacttattggtggcaggatcgacgggtagtggtaaatctgtttgtataaatggtattattacaagtattttattaaatgctaagccgcatgaagttaaacttatgttaatcgatccgaaaatggttgaactaaatgtttataacggaattccacacttattaattccggttgttacaaatcctcataaagctgctcaagctttagaaaaaattgtagctgagatggaaagacgttatgatttattccaacattcatcaactagaaacattaaaggttataacgaattaatccgtaagcaaaatcaagaattagatgagaagcaaccagaattaccttatatcgttgttattgtagatgagcttgcagatttaatgatggtagctggtaaagaagttgaaaatgcgattcaacgtattacacaaatggcacgtgcagcaggtatacatttaattgtagcgacacaaagaccttctgtggatgtaattacaggtatcattaaaaataatattccatctagaatagcttttgctgtgagttctcaaacagattcaagaactattattggtactggcggcgcagaaaagttacttggtaaaggtgacatgttatacgttggaaatggtgactcatcacaaacacgtattcaaggggcgtttttaagtgaccaagaggtgcaagatgttgtaaattatgtagtagaacaacaacaggcaaattatgtaaaagaaatggaaccagatgcaccagtggataaatcggaaatgaaaagtgaagatgctttatatgatgaagcgtatttgtttgttgttgaacaacaaaaggcaagtacatcattgttacaacgccaatttagaattggttataatagagcatctaggttgatggatgatttagaacgcaatcaggtaatcggtccacaaaaaggaagcaagcctagacaagttttaatagatcttaataatgacgaggtg |
307. | atggctgaaaaattacaaagggaactgagcaatcgccacatacaattaattgcaattggcggtgcaattggtacaggcttattcttaggtgctggtcaaacgattgcattaaccggcccttcaattctattaacatacatcattataggatttatgttatttatgtttatgcgaggtttaggagaaatcattatacagaatactgaatttaaatctttcgcagatgtaaccaatacatatattgggccttttgcaggatttgttaccggatggacatactggttctgttggattattacaggtatggctgaagtaacggctgtggcaaaatatgttagcttttggttcccagaaattccaaactggataagtgcactattttgtgtactgttattaatgtcattcaacctacttagcgcaagacttttcggagaattagaattttggttctctatcattaaaatagcgacaattattggtttaatagtagttggtttcgtcatgattctatttgcatttaaaactcaattcgggcatgccagtttcacaaatctatattgaacacgcatattcgctaaaggtgcttctggattctttatgtctttccaaatggcactattctcatttgtaggaattgaaatgattggtgttacagctggggaaacaaaagatccagttaaaacaattccaaaagcaattaacagtgtacccattagaattttaatattttacgttggggcgttagcggttatcatgtctattatcccttggcagcaagttgatcctgataacagtccattcgtaaaattattcgcattgatcggaattccgtttgctgcgggcttgattaattttgtagtattaaccgctgctgcttcatcatgtaacagtggtatattctcaaatagccgtatgcttttcggtttatcaagtcaacaacaagcacctccgaacttttctaagacgaataaatatggcgttccacatgttgcaatctttgcttcatcagcattattacttgtggcagcattactaaactatattttcccagatgcgacaaaagtatttacgtatgtgactaccatctctacagtgttatttttagttgtatggggtctgattatcattgcatatatcaattatagtcgtaaaaacccagatctacataaaaatgctacgtacaaactattaggtggcaaatatatgggctacttaatatttgtattcttcatttttgtgttcgggttattatttattaatgttgatacaagacgtgcaatttattttattccgatttggtttatacttttagcatttatgtacttaagatataaacgtatcgctgctaaatcaaataaa |
308. | atgaatttgttaaagaaaaataaatatagtattaggaagtataaagtaggcatattctctactttaatcggaacagttttattactttcaaacccaaatggtgcacaagccttaactacggataataatgtacaaagcgatactaatcaagcaacacctgtaaattcacaagataaagatgttgctaataatagaggtttagcaaatagtgcgcagaatacacctaatcaatctgcaacaaccaatcaagcaacgaatcaagcattggttaatcataataatggtagtatagtaaatcaagctacgccaacatcagtgcaatcaagtacgccttcagcacaaaacaataatcatacagatggcaatacaacagcaactgagacagtgtcaaacgctaataataatgatgtagtgtcgaataataccgcattaaatgtaccaactaaaacaaatgaaaatggttcaggaggacatctaactttaaaggaaattcaagaagatgttcgtcattcttcaaataaaccagagctagttgcaattgctgaaccagcatctaatagaccgaaaaagagaagtagacgtgcggcaccggcagatcctaatgcaactccagcagatccagcggctgcagcggtaggaaacggtggtgaaccagttgcaattacagcgccatatacgccaacaactgatcctaatgccaataatgcaggacaaaatgcacctaacgaagtgctgtcatttgatgacaatggtattagaccaagtaccaaccgttctgtgccaacagtaaacgttgttaataacttgccgggcttcacactaatcaatggtggcaaagtaggggtgtttagtcatgcaatggtaagaacgagcatgtttgattcaggagataataagaactatcaagcacaaggaaatgtaattgcattaggtcgtatacatggaactgatacgaatgaccatggcgattttaatggtatcgagaaagcattaacagtaaatccgaattctgaattaatctttgaatttaatacaatgactactaaaaacggtcaaggcgcaacaaatgttattatcaaaaatgctgatactaatgatacgattgctgaaaagactgttgaaggcggtccaactttgcgtttatttaaagtacctgataatgtgagaaatctcaaaattcaatttgtacctaaaaatgacgcaataacagatgcgcgtggcatttatcaactaaaagatggttacaaatactatagctttgttgactctatcggacttcattctgggtcacatgtttttgttgaaagacgaacaatggatccaacagcaacaaataataaagagtttactgtaacaacatcattaaagaataatggtaattctggtgcttctctagatacaaatgactttgtatatcaagttcaattacctgaaggtgttgaatatgtgaacaattcattgactaaagattttccaagtaacaattcaggcgttgatgttaatgatatgaatgttacatatgatgcagcaaatcgtgtgataacaattaaaagtactggaggaggtacagcaaactctccggcacgacttatgcctgataaaatactcgatttaagatataaattacgtgtaaataatgtgccgacaccaagaacagtaacatttaacgagacattaacgtataaaacatatacacaagatttcattaattcagctgcagaaagtcatactgtaagtacaaatccatatactatcgatatcatcatgaataaagatgcattacaagccgaagttgacagacgtattcaacaagctgattatacatttgcgtcattagatatctttaatggtctgaaacgacgcgcacaaacgattttagatgaaaatcgtaacaatgtaccattaaataaaagagtttctcaagcatatattgattcattaactaatcaaatgcaacatacgttaattcgaagtgttgatgctgaaaatgcagttaataaaaaagttgaccaaatggaagatttagttaatcaaaatgatgaattgacagatgaagaaaaacaagcagcaatacaagttatcgaggaacataaaaatgaaataattggtaatattggtgaccaaacgactgatgatggcgttactagaatcaaagatcaaggtatacagaccttaagtggggatactgcaacaccggttgttaaaccaaatgctaaaaaagcaatacgtgataaagcaacgaaacaaagggaaattatcaatgcaacaccagatgttactgaagacgagattcaagatgcactaaatcaattagctacggatgaaacagatgctattgataatgttacgaatgctactacaaatgctgacgttgaaacagctaaaaataatggcatcaatactattggagcagttgttcctcaagtaactcataaaaaagctgcaagagatgcaattaaccaagcaacagcaacgaaaagacaacaaataaatagtaatagagaagcaactcaggaagagaaaaatgcagcattgaacgaattaactcaagcaaccaaccatgctttagaacaaatcaatcaagcaacaacaaatgctgatgttgataacgccaaaggagatggtctaaatgccattaatccaattgctcctgtaactgttgttaagcaagctgcaagggatgccgtatcacatgatgcacaacaacatatcgcagagatcaatgctaatcctgatgcgactcaagaagaaagacaagcagcaattgacaaagtgaatgctgctgtaactgcagcaaacacaaacattttaaacgctaataccaatgctgatgttgaacaagtaaagacaaatgcgattcaaggaatacaagcaattacaccagctacaaaagtaaaaacagatgcaaaaaatgccatcgataaaagtgcggaaacgcaacataatacgatatttaataataatgatgcgacgctcgaagaacaacaagcagcacaacaattacttgatcaagctgtagccacagcgaagcaaaatattaatgcagcagatacgaatcaagaagttgcacaagcaaaagatcagggcacacaaaatatagtagtgattcaaccggcaacacaagttaaaacggatactcgcaatgttgtaaatgataaagcgcgagaggcgataacaaatatcaatgctacaactggcgcgactcgagaagagaaacaagaagcgataaatcgtgtcaatacacttaaaaatagagcattaactgatattggtgtgacgtctactactgcgatggtcaatagtattagagacgatgcagtcaatcaaatcggcgcagttcaaccgcatgtaacgaagaaacaaactgctacaggtgtattaaatgatttagcaactgctaaaaagcaagaaattaatcaaaacacaaatgcaacaactgaagaaaagcaagtggctttaaatcaagtggatcaagagttagcaacggcaattaataatataaatcaagctgatacaaatgcggaagtagatcaagcgcaacaattaggtacaaaagcaattaatgcgatttagccaaatattgttaaaaaacctgcagcattagcacaaatcaatcagcattataatgctaaattagctgaaatcaatgctacaccagatgcaacgaatgatgagaaaaatgctgcgatcaatactttaaatcaagacagacaacaagctattgaaagtattaaacaagctaacacaaatgcagaagtagaccaagctgcgacagtagcagagaataatatcgatgctgttcaagttgatgtagtaaaaaaacaagcagcgcgagataaaatcactgctgaagtggcgaagcgtattgaagcggttaaacaaacacctaatgcaactgacgaagaaaagcaggctgctgttaatcaaatcaatcaacttaaagatcaagcaattaatcaaattaatcaaaaccaaacaaatgatcaggtagacacaactacaaatcaagcggtaaatgctatagataatgttgaagctgaagtagtaattaaaccaaaggcaattgcagatattgaaaaagctgttaaagaaaagcaacagcaaattgataatagtcttgattcaacagataatgagaaagaagttgcttcacaagcattagctaaagaaaaagaaaaagcacttgcagctattgaccaagctcaaacgaatagtcaggtgaatcaagcagcaacaaatggtgtatcagcgattaaaattattcaacctgaaacaaaagttaaaccagctgcacgtgaaaaaatcaatcaaaaagcgaatgaattacgtgctaagattaatcaggataaagaagcaacagcagaagaaagacaagtagcactagataaaatcaatgaatttgtaaatcaagccatgacagatattacgaataatagaacaaatcaacaagttgatgatacaacaagtcaagcgcttgatagcattgctttagtgacgcctgaccatattgttagagcagctgctagagatgcagttaagcaacaatatgaagctaaaaagcgcgaaattgagcaagcggaacatgcgactgatgaagaaaaacaagttgctttaaatcaattagcgaataatgaaaaacgtgcattacaaaacatcgatcaagcaatagcgaataatgatgtgaaacgtgttgaaacaaatggcattgctacactaaaaggtgtacaacctcatattgtaattaagcctgaagcacaacaagcaataaaagcaagtgcagaaaatcaagtagaatcaataaaagatacaccacatgcaacagttgatgaattagatgaagcgaatcaattaattagcgacacactcaaacaagcgcaacaagaaatagaaaatacaaatcaagatgctgctgttactgatgttagaaatcaaacaatcaaggcaatagagcaaataaaacctaaagtaagacgtaaacgagctgcgcttgatagcattgaagaaaataataaaaatcaactcgatgcaatccgaaatacgttggatactactcaagatgaaagagatgttgctattgatactttaaataaaattgtaaatacaattaaaaatgacattgcacaaaacaaaacgaatgcagaagtggatcgaactgagactgatggcaacgacaacatcaaagtgattttacctaaagttcaagttaaacaagcagcgcgtcaatctgttggtgtaaaagccgaagctcaaaatgcactaatcgatcaaagcgatttatcaactgaagaagaaagactagctgctaaacatttagtagaacaagcacttaatcaggctattgatcagagcaatcatgcagataagactgcccaagttaatcaagatagtataaatgctcaaaatattatttcaaaaattaaaccagcgacaacagttaaagcaacagcattacaacaaattcaaaatatcgctacaaataaaattaatttaattaaagcaaataacgaagcgacagatgaagaacaaaatattgcaatagcacaagttgaaaaagagttaattaaagctaaacaacaaatt |
gctagtgcagtgactaatgcagatgtggcatatttattgcatgatgagaaaaacgaaattcgtgaaatcgaacctgttattaacagaaaggcgtctgctcgagaacaattgacaacattattcaacgataaaaaacaagcaattgaagcgaatattcaagcaacggtagaagaaagaaatagtatattagcacagttacaaaatatttatgacactgctattggacaaattgatcaagatcgtagcaatgcacaagttgataaaacagcatcattaaatctacaaacaatacatgatttagatgtacatcctattaaaaagccagatgctgaaaaaacgattaatgatgatcttgcacgcgtcactgctttagtgcaaaattatcgaaaagtaagtaatcgtaataaggctgatgcattaaaagctataactgctttaaaaattacaaatggatgagaattaaaaacagcacgcactaatgctgatgttgatgcagttttaaaacgatttaatgttgcattaagcgatatagaagcagtaattactgaaaaagaaaatagcttactgcgaattgataacattgctcaacaaacatatgcgaaattcaaagcgatcgcaacaccagaacaattagctaaagtaaaagtattaattgatcaatatgttgcagatggcaatagaatgattgatgaagatgcgacattaaatgacatcaaacaacacacgcaattcattgttgatgaaattttagcaattaaattaccagctgaagcgacgaaagtatcaccaaaagaaattcagccagctccaaaagtttgtacgcctattaaaaaagaagagacacatgaatcgcgcaaagttgaaaaagaacttccaaatacaggttctgaaggaatggatttaccattgaaagaatttgcactgattacaggtgcggctttgttagctagaagacgtactaaaaacgaaaaagaatca |
309. | atgagtgttgaaatagaatcaattgaacatgaactagaagaatcaattgcatcattgcgacaagcaggcgtaagaattacacctcaaagacaagcaatattacgttatttaatttcttcacatactcatccaacagctgatgaaatttatcaagcactttcacctgattttccaaatataagtgttgcgacaatatataataacttaagagtgtttaaagatattggaattgtaaaagaattaacatatggagactcatcaagtcgattcgactttaatacacataatcattatcatattatatgtgaacaatgtggtaagattgttgattttcaatatccacagttaaatgaaattgaaagattagctcagcatatgactgactttgacgtaacacatcatcgaatggaaatttatggagtttgtaaagaatgccaagataaa |
310. | atgagtgaaaaacaacaaattctcgattatatagaaacaaataaatatagttatatcgaaatcagtcatagaattcatgaacgtcctgaacttggtaatgaagaaatatttgcgtctcgaactttaatagatcgtttgaaagagcatgattttgaaattgaaaccgagattgctgggcatgcaactgggtttatagcgacatatgattcaggacttgacgggccagctataggttttttagcagaatacgatgctttgccaggattgggtcatgcttgtggtcataatatcattggaactgcaagtgttcttggtgcaattggtttgaagcaagtgattgaccaaattggtggtaaagtagtcgttcttggatgtccagctgaagaaggtggggaaaatggtagcgctaaagcttcttatgtcaaggctggtgtgattgatcaaatagacattgccttaatgattcatccgggaaatgaaacttataaaacgattgatactttggcagtggatgttttagatgttaaattttacggaaaaagtgctcatgcctctgaaaatgcagatgaagcgttaaatgcattagacgctatgattagttattttaatggtgtagcacaactacgacaacatattaaaaaagatcaacgtgtgcatggtgtgattttagatggcgggaaagcagctaatattattccagactatacacatgctcgtttttatactagagcaatgacgcgtaaagaattggatatattaacagaaaaagtaaatcaaatcgcacgtggagctgcgatacagactggttgtgattatgaatttggtcgaattcaaaacggtgtgaatgaattcattaaaacgccgaaattagatgatttatttgctaaatatgctgaagaagttggtgaagcagttattgatgatgattttggttatggctctacggatacagggaacgtaagtcatgttgtgccaacaatacatcctcatattaaaataggatcacgtaatttagtaggacatacgcatagatttagagaagcggctgcgagtgtacatggtgatgaagcattaattaaaggcgctaaaataatggcgttgatggggttagagttaattacaaatcaagacgtttatcaagacattattgaagagcatgcgcatttgaaagggaatgggaag |
311. | atgactacgaccttcattattagctacattattttagcgctcattattgttggggttatcaatttatttttaataagatcaagaaaaaaaggcaaacgccaacaaaaggaacaacaatttacgacacgtcaatcaaatcaatctaaatttaaagctagtgatttagacaaaacaactgatcaatcgacacaacgtatgacgcatgaagagttgcgtgttgacaatcaagatgatcatagccaagttagtctaaatggttacacaaaggggtctgagaaagatcaagaagcattcactaataataaggatgaggaagcagttgctgctaaaaatcctgaatcagaagaatataaagtgaatgaaaaaataaaaaaagaacataaaaactttatttttggtgaaggtgtttcacgcggtaaaatattagcggcattattattcggtatgtttattgcgattttaaaccaaacattattaaatgttgctttaccaaaaattaatacggaatttaatatttctgcgtcaacagggcaatggttgatgacgggattcatgttagtaaacggtattttaataccaattacggcgtatctatttaataaatattcatatcgaaaattatttttagttgcgttagtactctttacaattggttcattaatctgtgcgatttcaatgaatttcccaatcatgatggttggacgtgtattacaagccattggtgcaggtgtactaatgccattaggttcaattgttattattacaatttatccacctgaaaaacgtggtgctgccatgggtacaatgggtatcgcaatgattttagcacctgcaattggtccaacattatcaggttatattgtacaaaattaccattggaatgtgatgttttacggtatgttcattatcgggattatcgctattttaattggttttgtatggtttaagttatatcaatatacaacaaaccctaaagctgatatcccaggtatcatttttagtacgattggttttggtgctttgttatatggtttctcagaagctggcaacaaaggttggggttcagtagagatagaaacaatgtttgcgattggtattatctttattattctattcgttattagagaattaagaatgaaatcaccaatgttgaatttagaagtattgaaattcccaacatttacattaacaacaattattaatatggttgtaatgttaagtttatatggtggtatgattttattaccgatttatttacaaaatttacgcggattctcagcattagattccggattgttattattacctggttctctaattatgggtctactaggaccatttgcaggtaaattgttagatactattggtttaaaaccattagctatctttggtattgctgtaatgacttatgcaacatgggaattaactaaattaaatatggatacaccatatatgacaatcatgggtatctatgtacttcgttcatttggtatggcatttataatgatgccaatggtaactgcagctattaatgcgttaccgggacgacttgcctctcatggtaatgctttcttaaatacgatgcgtcaattagcaggctctataggtacagcaatcttagttactgtaatgacaacacaaactacacaacacttatcagcttttggggaagagttagataaaacgaatcctgttgtacaagatcatatgcgtgaattagcatcacaatatggcggacaagaaggcgcaatgaaagtgttactacaatttgtaaataaactagcaacggttgaaggtattaatgatgcatttatagttgcaacgatatttagcatcatcgccttaattttatgtttatttttacaaagtaataaaaaagcaaaagctacagctcaaaagttagatgcagataatagtatcaatcatgaa |
312. | atgattaaaaataaaatattaacagcaactttagcagttggtttaatagcccctttagccaatccatttatagaaatttctaaagcagaaaataagatagaagatatcggccaaggtgcagaaatcatcaaaagaacacaagacattactagcaaacgattagctataactcaaaacattcaatttgattttgtaaaagataaaaaatataacaaagatgccctagttgttaagatgcaaggcttcattagctctagaacaacatattcagacttaaaaaaatatccatatattaaaagaatgatatggccatttcaatataatatcagtttgaaaacgaaagactctaatgttgatttaattaattatcttcctaaaaataaaattgattcagcagatgttagtcagaaattaggctataatatcggcggaaacttccaatcagcgccatcaatcggaggcagtggctcattcaactactctaaaacaattagttataatcaaaaaaactatgttactgaagtagaaagtcagaactctaaaggtgttaaatggggagtgaaagcaaattcattcgttacaccgaatggtcaagtatctgcatatgatcaatacttatttgcacaagacccaactggtccagcagcacgagactatttcgtcccagataatcaactacctcctttaattcaaagtggctttaatacatcatttattacaacattgtcacacgaaagaggtaaaggtgataaaagcgagtttgaaatcacttacggcagaaacatggatgctacatatgcttacgtgacaagacatcgtttagccgttgatagaaaacatgatgcttttaaaaaccgaaacgttacagttaaatatgaagtgaactggaaaacacatgaagtaaaaattaaaagcatcacacctaag |
313. | atgcaatcaacgaaaaccaaaacgaagcatttttcatttttattgctaattacgttaggcgtcatgaccgcttttggcccactaactatagatatgtacgtaccatcattacctaaagtgcaaggtgattttggttctactacatcagaaattcaattaacattatcattcacaatgattggtcttgcactaggccaatttatctttggacctttatccgatgcttttggtcgcaaacggattgctgtatccattttgatcattttcattttggtatcaggtttgtctatgtttgttgatcaattgccattattcttaactttacgatttattcaaggtttaactggtggtggcgtcatcgtgattgcaaaagcctctgctggtgataaatttagtggcaacgcactcgctaaatttttagcatctttaatggtagttaatggcatcatcactattcttgcaccattagccggtggattagctttatccgtagcaacatggcgttctattttcacaattttaactattgtggcactcatcattttaattggcgtcgcttctcaattacctaaaacatctaaagatgaattaaagcaggtgaattttagtagcgtcattaaagattttggaagtcttttgaaaaaaccagcatttattattccaatgctattacaaggtttaacttatgtaatgctatttagttattcatctgcatcgccatttattactcaaaaattgtataatatgacaccccaacaatttagtatcatgtttgctgttaacggtgtaggtttaatcattgtcagtcaagtcgttgctttattagtagaaaaattacatcgccacatattattaatcattttaactattatacaagtggtaggtgttgctttaattatcctgacacttacattccatttaccactttgggtcttactcatcgcattcttcttaaatgtgtgtcctgtgacgtcaattggaccgcttggtttcacaatggctatggaagaacgaacaggtggcagtggtaacgcatcaagtttacttggcttattccaatttatcttaggtggcgctgttgcaccattagttggcttaaaaggcgaatttaatacatcaccatatatgattattatcttcattacagccattctattagtcagtctacaaatcatttactttaaaatgattaaaaagcaacatgtcgca |
314. | atgatgtatggatatccagagaaatggttggaaggtatgacaactggagaaggtatcgcggcagaattacgcttaggcattgtgaatggtcacatagctgaaggtacgttactcactgaaaatcaaatggcaaagcaatttaatgtgagtcgttcgccaattcgagatgcatttaaattattgcaacaaaatcaactcatccaattagaaagaatgggtgcacatgtgttgccgtttggggaacaagaaaagaaagaaatgtatgatttgcgactgatgttagagtcatttgcattttcaagagttaaaaatcaagagcgactacctatcgtaaaagaaatgaagaaacaacttgaaatgatgaaagtggcagtaaaatttgaggatgcagaatcatttacgaagcatgactttgaatttcatgaaacattaatcaaagcatctaatcatcaatatttaaactcattttggagtcatttaaaaccagtaatgatggcactcgttttaacatccatgcgacaacgtatgcaacagaacccgcaagattttgaacgcatacatcataatcatcaagtgtttatttgatFagtggaacaatacgacagtcaaattttgaaagaagcgtttcatttaaatttcgacgatgttggtaaagatattgaaggattttggttgaat |
315. | atgggaagttttttcaataaaatagcacgaaaagaggatccggctatctatcaaaataaagatggtcatttaaagcgtacacttcgggtgcgtgatttcttagctttaggtgtaggaacaattgtatcgacatctatctttacgctacctggcattgttgctgcagaacatgcaggaccggccgttgcgttatcattcttactcgctgctattgttgctggtttagttgcatttacttatgcagaaatggctgccgctatgccatttgcaggttcagcctattcttgggtcaatgtattatttggtgaattttttggatgggttgccggttgggctctattagctgaatattttatcgccgtagcctttgttgcatcaggattctcagcgaatttacgcggacttgtgaaaccaattggcatcgaattacctgcagcattatcaaatccatttggtacaaatggcggttttatcgatattattgctgctatcgttattttattaactgcattattactatcacgtggtatgtcggaagcagctcgtatggaaaatattttagttattttaaaagtattagctattattttatttgtcatcgtaggtttaacagcaataaatgttagtaactatgtgccatttattccagaacacaaagtaactgctacaggtgactttggtggatggcaaggcatatatgctggtgtttcaatgattttcttagcgtatatcggtttcgattctatcgcagcaaactcagcagaagcacttgatcctcaaaagacaatgcctagaggtattcttggttctttaagcgttgctatcgtattatttattgctgtagcacttgtgttagttggtatgttccattactcacaatacgcaaacaatgctgaacctgttggttgggctttacgtcaaagtggtcatggtgttgtagcagctattgttcaagctatctctgttatcggtatgtttacagcattaattggtatgatgttagcaggctcacgtttactttattcatttggacgtgacggcttattaccttcatggttaagccacttaaacgacaaacatttacctaatcgcgcactagttatacttactattattggtgttttaattggttctatgttcccattcgcatttttagcacaattaatttcagcaggtacacttgttgcatttatgttcgtttcattagcaatgtatcgtttgagaaagcgtgaaggtaaagatctaccaattcctgcatttaaattacctttatatcctgtgttaccagcaattacatttgttttagtattgctagtattctggggattaggattcgaagcgaaattatacactttaatttggtttattgttggtatcatcctatatttaagttatggacttagacattctaagaaaaatgacgtagctgaataccacccaccaaaa |
316. | atgaatagtgataatatgtggttaacagtaatggggctcattattattatttcaattgtaggtttactcattgccaaaaagataaatccagttgtaggtatgacaatcataccttgcttaggggcaatgattttaggatatagtgtgacagatttggttggattttttgctaaagggttagatcaagtcatcaacgttgttattatgtttatctttgccattattttctttggcatcatgaacgatagtggtttattcaagccgcttgtcaaacgcttaatattaatgacacgaggcaatgtcgtcattgtctgtgcaatgacagctttaattggcacaatagcccaattagatggggccggtgcggtaacatttttgctttctattcctgcattattacctttatataaagcgttaaatatgaataaatatttattgattttactattagcattaagcgcggcgattatgaacatggtaccttggggaggtccaatggctcgtgtagctgcagtgttaaaagccaaaagtgtcaatgaattatggtatggattaatacctattcaaataataggtttcattcttgttatgttgtttgcggtatatcttggatttaaagaacagaaacgtatcaaaaaagcaatagagagaaatgaattaccgcaaacacaagatatagatgtacataaattagttgaagtatatgaacgagatcaagatgtaaggtttcctgtaaaaggacgtgcaagaacaaaatcatggataaaatgggtgaatacagctttaactttagctgttattctatcgatgttaataaatattgcgccacctgaatttgcattcatgataggtgtttcgttggcacttgttattaattttaaatcagtggatgaacaaatggaacgattaagagcgcatgcgccgaatgcattaatgatggctgcagtgattattgcagcaggtatgtttttaggtgtactaaatgaaaccggtatgcttaaagcgattgcgaccaatttaatcaaagtgattcctgcagaagtaggaccatacttgcatattattgtaggtttacttggcgtaccattagatttactaactagcacagacgcttattattttgctgtgttaccgattgtcgaacaaacagcagggcaatttggtgtaccgtctgtatcaacagcttattcaatggtcatagggaatattataggtacatttgtcagcccattttcaccagccttatggttggcaattggtttagcagaggcaaacatgggcacgtatattaagtatgcattcttttggatttggggattcgctatcgttatgttagtaattgcaatgttgatgggcattgtgacgatt |
317. | atggaaaacacggttaaatatcgtaagtttatactccctatcgttgtaggtctccttatttgggcacttacaccttttaaaccggatgctgtggatccaacagcatggtatatgttcgcaatattcgtcgcgacaatcattgcttgtattacacaaccgatgccaattggggccgtctctataattggatttacaatcatggtactcgttggcattgttgacatgaaaacggctgtcgctggttttggtaataatagcatttggttaattgctatggcatttttcatttcgagaggatttgtgaaaacaggtcttggtagacgtatcgcacttcatttcgtcaaattatttggtaaaaaaacattaggattagcatattctatcgtcggtgtagatttaattctagcgcctgctacaccaagtaataccgcgcgtgctggtggaatcatgttcccaattatcaaatcactttctgaatcatttggttcgaaaccgaaagacggatcagcacgcaaaatgggtgcatttcttgttttcacagaattccaaggtaatttaattactgcggctatgtttttaactgcaatggccggtaacccccttgcacaaaatttagcatctagcacatctaatgttcacattacatggatgaattggtttctagctgctttagttcctggacttgtttccttaattgttgtaccttttattatttataaaatttatccaccaactgttaaagaaacaccaaatgctaagagttgggctgaaaatgaattagcgactatgggtaaaatcgctttagctgaaaaatttatgattggtatttttgtcgttgcgttaacactatggattgtcggaagtttcattcatattgatgcaactttaacggcctttattgcgctagcattgttattattgacaggcgtcttaacatggcaagacattttaaacgaaacaggtgcttggaacacattagtatggttctcagtattagtgttaatggccgaccaattaaacaagcttggatttattccttggttaagtaaatccattgctacaagtcttggtggcttaagctggcctatagtcctggtcattttaatattgttctacttctattcacattacttatttgcaagttctacagcacatatcagtgcgatgtatgcagcattactaggcgttgccatcgcagccggtgcaccaccattattcagtgcattaatgttaggtttcttcggtaacctattagcttcaacaacacactatagtagtggtccagcgccgattctattctcttcaggttacgtgactcaaaaacgttggtggacaatgaacttaatattaggtttcgtctactttattatctggattggtttaggatcactttggatgaaagtaattggtatattt |
318. | atgaataaagtaattaaaatgcttgttgttacgcttgctttcctacttgttttagcaggatgtagtgggaattcaaataaacaatcatctgataacaaagataaggaaacaacttcaattaaacatgcaatgggtacaactgaaattaaagggaaaccaaagcgtgttgttacgctatatcaaggtgccactgacgtcgctgtatctttaggtgttaaacctgtaggtgctgtagaatcatggacacaaaaaccgaaattcgaatacataaaaaatgatttaaaagatactaagattgtaggtcaagaacctgcacctaacttagaggaaatctctaaattaaaaccggacttaattgtcgcgtcaaaagttagaaatgaaaaagtttacgatcaattatctaaaatcgcaccaacagtttctactgatacagttttcaaattcaaagatacaactaagttaatggggaaagctttagggaaagaaaaagaagctgaagatttacttaaaaagtacgatgataaagtagctgcattccaaaaagatgcaaaagcaaagtataaagatgcatggccattgaaagcttcagttgttaacttccgtgctgatcatacaagaatttatgctggtggatatgctggtgaaatcttaaatgatttaggattcaaacgtaataaagacttacaaaaacaagttgataatggtaaagatattatccaacttacatctaaagaaagcattccattaatgaacgctgatcatatttttgtagtaaaatcagatccaaatgcgaaagatgctgcattagttaaaaagactgaaagcgaatggacttcaagtaaagagtggaaaaatttagacgcagttaaaaacaaccaagtatctgatgatttagatgaaatcacttggaacttagctggcggatataaatcttcattaaaacttattgacgatttatatgaaaagttaaatattgaaaaacaatcaaaa |
319. | atgattaatcagtctatatggcgcagtaactttcgcattttatggctcagtcagtttatagcgattgctggactgacagtacttgtgccattattgccaatttatatggcatcactacaaaatctatcagtcgtagaaatacagttgtggagtggtatagcgattgctgctccagctgtaacgacgatgatagcttcgccgatatgggggaagctaggtgataagatcagccgaaaatggatggtgttaagagcgttacttggtttggcggtatgcttatttttaatggcattgtgtacgacaccattacagtttgtacttgtgaggttattgcagggactatttggtggtgttgttgatgcatcaagtgcgtttgcgagtgcagaggcgccagctgaagatcgtggaaaggtattaggaagactgcaaagttcagtcagcgcagggtctcttgtggggccattaattggcggtgttacagcttcgatattaggttttagtgcgttactgatgagtattgccgttattacttttattgtctgtattttcggtgcattaaaattgattgaaacgacacatatgccaaaatcacaaacaccaaatattaataaaggtattcgccgttcatttcaatgtctattatgcacacaacaaacatgtcgatttattatcgttggcgttttagcaaactttgctatgtatggcatgctaactgcattatcaccacttgcttcatcagtgaatcatacagcgatagatgaccgtagtgtgattggatttttacagtccgcattttggacggcttcgatattaagcgcgcctttatggggacgctttaatgataaatcatatgttaaatcagtatatatatttgccacgattgcatgtggttgtagtgcgatactgcaaggtttagcgacgaatatagagtttttaatggctgcaagaatacttcaaggattaacatatagtgcattgattcaaagtgtcatgtttgttgtcgtgaatgcgtgtcatcaacaacttaaaggcacatttgttggaacgacgaacagtatgttagttgttggtcaaattattggcagtcttagtggcgctgccattacaagttatactacaccagctactacgtttatcgttatgggcgtagtatttgcagtaagtagtttatttttaatttgttcaaccatcactaatcaaatcaacgatcacacattaatgaaattatgggagttgaaacaaaaaagtgcaaaa |
320. | atgaagcgattattcgatgtagtgagttcaatatatggtttagtagttttaagtccgattctgttaattacagcattactaattaaaatggaatcacctggaccagccattttcaaacaaaaaagaccgacgattaataatgaattgtttaatatttataagtttagatcaatgaaaatagacacacctaatgttgcaactgatttaatggattcaacatcgtatataacaaagacagggaaggtcattcgtaagacctctattgatgaattgccacaattattgaatgttttaaaaggagaaatgtcaattgtaggtcctagaccagcgctttataatcaatacgaattaatcgaaaaacgtacaaaagcgaacgtgcatacgattagaccaggtgtgacaggactagctcaagtgatggggagagatgatatcactgatgatcaaaaagtagcgtatgatcattattacttaacacatcaatctatgatgcttgatatgtatatcatatataaaacaattaaaaatatcgttacttcagaaggtgtgcatcac |
321. | atggcacaacttaattcaaagatagcttccttaaaattattcgcaagttacgccatagcaacttatattttagttatattaacgagtgcattaaatctttttaaaggttatgtggccgatacgttctatattgctgaaacattgctaatcgttttaaccatcattttaattattattttaacaacggaacaaacatggaagcatcatgacctatggcgacgtatcgtcgaagtgttgttattgttgatgacattaacaggcaacgtatttacattattaatgtttgtaagtattagacgttaccaacgtacatcgcaaatacatagttataacgggtgggaatcgtttatacgaaaaactactagacatcgtattgcgattatcgggttacttattttagtctacatgctgacattatcaattgtgtcacaatttacatttgatacgacattggctactaaaaatcagttcaatgcactgttacatggaccgagtctagcctatccgtttggtactgatgatttcggtagagacttatttacacgcgtagttgtaggaacgaagctgacattttcaatttcaattatttcagtagttattgcagttatttttggtgtgttactaggcactatcgcaggttattttaatcatattgataatttaataatgcgaattttagatgtagtgtttgcaattccatcattattgttagcggtggcaattattgcatcatttggagcaagtattccaaatttaattattgctttaagtatcggtaatataccatcatttgcacggacaatgcgtgccagtgttttagaaattaaacgcatggaatatgtagatgcagcacgtatcactggtgaaaacacttggaatatcatatggcgttatattttaccgaatgcgattgcgcctatgattgtacgtttttcattaaatataggtgtggttgtattaacaacaagtagtttaagtttcctaggacttggtgttgcacctgatgtagctgaatggggcaacattttacgtaccggtagtaactacttggaaacgcacagtaatttagctattgtacctggtgtttgtattatgttcgtcgttttagcatttaattttataggtgatgcagtgcgtgatgcactagatccaagaattcat |
322. | atgaaaacaatacatttgtttcgcatctaccactcttttttattgaaaaagtggtatttgattatctatttactatttatattagcggcactccttattacattaacgacaatccaacatgtaacagaagatgacaatcattttaatataggtgtcgtagataaagatcaatcaagtgaaacgaaattaatcttaaactctattggtaaagggagtaacctaggaaaaaacgtgagcattaaagcatatgatgataagcaagcacatactttgttaaaaaaacataaacttcaaggctattttgtttttgataaaggtatgaccaaggcattttataaacaaggcgaactaccaatttcagtatatacatatgatcaacaatccatgaaaagtgtcgtgctatctcagctaacagattctgtttaccaacgtcttatgcgatcaatgggtggcatcttagcttttcaagacttagcaccgaaagcatcacattctgacagtatcaatgttatgactgatttgctgattacaggattaaaccgttcaggtgcatttaacttagaaccgattcatttatacgatacgggcagttattatgcaattacaggatttttaacaacggtattcatctttgcactatctttatttacagttttgaaaatgaatcaagatactgtattgaaagcgcgattgaaaatgtttcatttttctaaagagcgtttattaatcattcgtacgttgattacatggttttatactatgttatggagtatcgttggtgtagtttggattgtgttcagtattccgaatatctttgaattatataattggccaacgttagccattcatttaagctattatgttacctttttaatactgtggttattactcatcgaacttttaacaacaggcttgttgaatagtattagtaaagtcatattagctattgtcatcctggtgttatctggtttaacaatacctacgatttttttacaacatatagcaaatggtgttttcaatattcaaccgttcgcagttgtaacaaatcaattgttagaaattattttaaacaactacattttagaactgcaccctagtttctatcttagcttcatcgcacttttgataattaatttagctgtattggtttggaggtatcgtcaa |
323. | ttgaaaaaacaagttattatttcgggcctcatgttattttcactattttttggagccggaaatttaatattcccgcccatgcttggccatacagcgggtcaaaatatgtggattggtatgctaggctttgcccttacaggcatattactcccctttattactgttattgttgttgcattttatgatgaaggtgttgaaagtgtaggcaatcgtatacatccatggttcgggtttatttttgctgtcgtgatttacatgtctatcggagcattttacggtattccacgtgctgcaaatgtcgcgtacgaaattggtacaagacacattttacctgtgcataaccaatggactttaattatattcgcagcaatcttttttgccatcgtttactggattagtttaaatccatcgaaaatcgttgataatttaggtaaattattaacaccgttattactattaatggtcgctctattaagtattgctgtcattttcaaccctgaatctgcactaagtgcacctaaggataaatatataacacatcctttcatttcaggaagtttggaaggctattttacaatggatcttgttgctgcgttagctttttccgtagtcattgtcaatggctataagtttaaaggcctcacagatcgcatgaaaattttaaaatatgtctgcttttcaggtcttattgcagccatattacttggaatgatttactttgcacttgcatacgttggggcatcaacagctccaggaaactttaaagatggtacagatatattgacgtacaactcattacgattatttggttcgttcggtaacctcgtatttggaatgacggttatccttgcatgcctaacaacatgtataggactcgtcaatgcttgcgccacatttactaagaaacacgtacctaagttttcttataaaatattcgcacttattttctctatcatagggttcttatttacaacacttggtttagaaatgattttaaaaattgctgtcccattattgactttaatatatcccgtgtcgattgcacttgtactcatatcatttgctaacatgtttagcacattcagattcagttgggcctatcgactcgcaactgttattacattgattatttcaattttacaaatactaaatagtttcaacttattacacggtgttattttgaaatcgtttatgatgttacctttagcagatatcgatttagcttggcttgtaccattcatgctctttgctattatcggtttcataatcgatgtatttatacgccgtccgaaacaagcgacaact |
324. | gtgaaacattatttgactaaatttgtagcaatgctaataactgctgctatggtgtgtagctttgggttactgaaaagtcaggcagcagaacaacaaagtattagtgatgtatatagtgtgataacggatgcgaaatctgcactttctaataattcgatatcgaatgacaataagcagaaagcaattgagcaagtggtaagtgcagttaagaaattatcgcttgaagataatagtgaaagtaatgctgtcaaatcagatgtgagaaagcttgaagatgcaaaagcgaatgataatcaaaaagatacactttcgcaattaacgaagtcattaattgcttatgaagagaaattggctagtaaagatgcgggttctaaaattaaactattgcaacagcaagtcgatgctaaagatgctgcgatgacaaaagcgattaaagataaaaataaagcggaattagaatctttgaacaatagtttgaatcagatttggacaagtaatgaaacagtgattcgcaattatgacgcaaatcaatatggacaaattgaagtcgcattattacaacttagaattgcaattcataagtcaccattagatacggcaaaagtgtcacatgcttggacaacttttaaatcaaatattgatcatgtcgataaaaaaagtaatacgtctgcaaatgatcaataccatgtatcacaattaaatgatgcgttagagaaggcgattaaagctatcgacgacaatcaattgtcggatgctgatgctgcgcttacacattttatagaaacttggccgtatgttgaaggtcaaattcaaactaaagacggtgctttgtatacgaaaattgaagataaaataccatattatcaaagtgtattagacgaacataataaagcacatgtgaaagatggtttagtagatttaaataaccaaattaaagaggttgttggccatagttatagcttcgtcgatgtgatgattatctttttacgtgaagggctagaagtgttgttaattgtaatgacattgactaccatgacgcgtaatgtaaaagataagaaagggactgcaagtgtgattggtggtgcaattgccggacttgtactgagtattatcttagcaattacgtttgtagaaactttagggaatagtggcattcttcgtgaaagtatggaagcgggattaggtatcgttgcggtcatattaatgtttatcgttggtgtttggatgcacaaacgttcaaatgcaaaacgttggaatgacatgattaaaaatatgtatgctaatgcgattagtaatggtaatttggtattgttagcgacgattggtttaatatctgtgttgcgtgaaggtgtcgaggttatcattttctatatggggatgataggtgagctagcgaccaaagattttattattggtattgctttagctatcgttattttaatcatctttgcattattatttagatttatagttaaattaatacctattttctatatatttagagtgttgtcgatctttatttttattatgggattcaaaatgcttggcgtaagtattcaaaagttacaattattaggtgcgatgccaagacatgttattgaaggattcccaacgattaactggttgggcttttatccaagttatgaaccattgatagcacaaggtgcttatattatggtagttgctatcttaatctttaaatttaaaaaa |
325. | mnkqifvlyfnifliflgiglvipvlpvylkdlgltgsdlgllvaafalsqmiispfggtladklgkkliiciglilfsvsefmfavghnfsvlmlsrviggmsagmvmpgvtgliadispshqkaknfgymsaiinsgfilgpgiggfmaevshrmpfyfagalgilafimsivlihdpkksttsgfqklepqlltkinwkvfitpviltlvlsfglsafetlyslytadkvnyspkdisiaitgggifgalfqiyffdkfmkyfseltfiawsllysvvvlillvfandywsimlisfvvfigfdmirpaitnyfsniagerqgfagglnstftsmgnfigpliagalfdvhieapiymaigvslagvvivliekqhraklkeqnm |
326. | mlfylfhftisfistvlfsiifnapkrllvacgfvgaiawtiyqltvdlefgkvgasflgslilglmshtmsrrykrpviifivpgiiplvpggaayqatrflvsndytsavntflevtlisgaiafgilvseilyylytrikqlygkikgktykksynmnnrv |
327. | minavviavilmimlclcrlnvvislfisalvgglisgmsiekvinvfgknivdgaevalsyallggfaalisysgitdylvgkiinaihaensrwsrvkvkvtiiiallamsimsqnlipvhiafipivippllslfndlkidrrligliigfglcfpyvllpygfgqifqqiiqsgfakanhpiefnmiwkamlipsmgyivglliglyvyrkpreyetrkisdsdnvtelkpyilivtivailatflvqtftdsmifgalagvlvffisraynwyeldakfvegikimayigvviltangfagvmnatgdidelvktltsitgdnklfsiimmyviglivtlgigssfatipiiaslfipfgasigldtmalialigtasalgdsgspasdstlgptaglnvdgqhdhirdtcvpnflfyniplmifgtiaamvl |
328. | mnhnviivialiivvismlamlirvvlgpsladrvvaldaiglqlmavialfsillnikymivvimmigilaflgtavfskfmdkgkviehdqnhtd |
329. | mnrnivklvvfmlilvvavagcgqkdteektemttikdelgtekikknpkrvvvleysfadylaaldmkpvgiaddgstknitksvrdkigayesvgsrpqpnmevisklkpdliiadvsrhkkikselskiaptimlvsgtgdynanieafktvakavgkekegekrlekhdkilaeirkkieqstlksafafgisragmfinnedtfmgqflikmgiqpevtkdktthvgerkggpyiylnneelaninpkvmilatdgktdknrtkfidpavwkslkavkdnkvydvdrnkwlksrgiiasesmaedlekiaekak |
330. | mtgeqftqikrpvsrltekvlgwlcwvmllvltvitmfialvsfsnntsianlentlnnnafiqqllagngynttqfviwlqngiwaiivyfivcllisflalismnirilsgflflisaivtiplvllivtliipilffiiammlfirkdkvemvapqyyeeyngpiydyrepvyerpqpkddyydvpkyekeldksntvydqeqerdkydqfpkraveseynhderteeepsvlsrqakykqksteelgieddgyyaepevdpkelkaqqkrekaeikakkkekrkaynqrmkerrknqpsavsqrrmnfeerrqiynndiseernssevkdkkeqe |
331. | mentinesekkkrfklkmpgafmilfiltvvaviatwvipagaysklsyepssqelkivnphnqvkkvpgtqqeldkmgvkikieqfksgainkpvsipntyerlkqhpagpeqitssmvegtieavdimvfilvlggligvvqasgsfesgllaltkktkghefmlivfvsilmiiggtlcgieeeavafypilvpifialgydsivsvgaiflassvgstfstinpfsvviasnaagttftdglywrigacivgaifvisylywyckkikndpkasysyedkdafeqqwsvlkdddsahftlrkkiiltlfvlpfpimvwgvmtqgwwfpvmasafliftiiimfiagtgksglgekgtvdafvngasslvgvsliiglarginlvlnegmisdtilhfssslvqhmsgplfiivllfiffclgfivpsssglavlsmpifapladtvgiprfvivttyqfgqyamlflaptglvmatlqmlnmryshwfrfvwpvvafvlifgggvlitqvliys |
332. | msffkrlkdkfatnkeneevkslteeqgqdkledthsegstqdandlaenaevkkkprklseadfdddglisiedfeeieaqkmgakfkagleksrqnfqeqlnnliaryrkvdedffealeemlitadvgfntvmtlteelrmeaqrrniqdtedlrevivekiveiyhqeddnseamnledgrlnvilmvgvngvgktttigklayrykmegkkvmlaagdtfragaidqlkvwgervgvdvisqsegsdpaavmydainaaknkgvdilicdtagrlqnktnlmqelekvkrvinravpdapheallcldattgqnalsqarnfkevtnvtgivltkldgtakggivlairnelhipvkyvglgeqlddlqpfnpesyvyglfadmieqneeittvendqivteekddnhgsk |
333. | mlkkwlnsnvkqffvitfisviltlilfsthiydyivngtvfsgagdgfrqmmpfqmylyehlrsfsslydasfglggdymkglsyyyslsplmwlnflfikigetvgifnpttihfwptnqlimamiraiitfvvtfylfkilhfkrsanmiatilygmstvviyfnftwsfygnllyllplsilgleryfqqrkigifivaialtlfsnfyfsyyqaiiigcyylyrliftykydivsrtqklicvisatvlsvlssvfglftgisaflendrkqnpnvdipfltpldyhyfffsdgfyitisiltivallsfklyrfyfyrlfaivtwilfigslsqyfdsafngfsfperrwvyilalsssalcglfiqhlstlnmkyylirtipvciiailyvllspthplalivgiillivlavilkfslwrykkltvailvlivmiqqivildnnknmaikpyqqslstlkqhdyhsnyvnqlikkinqnatgsfnridymsdyalnspfiyhyngislyssifngdilkyydktlqinmpidknstyrllgnrqnllslwnvndrirvnhddnlpygfkiksehkdnkvrwihskntihypsahitnkvfsnkelkspldkeqamlqgivsnnikdvnthfkanknllsdstiklnsaawqsptkhllqvkqnnggltvqlpksvsnqfkdlyfemdlellspdkahdvkvneytqernkltykyrrvvtpvtirikapdrirlslpkgkyrvnlkgiygedyttlkdasnsleavkvsktkhgytitknknssgyivlptaynqgmkatsgdqslkveqvngvmtgikapknitkiqlsytppyyyllititifgiicsiiftrwarqk |
334. | mrqlaqakkkstakkkttskkrtnsrkkkndnpiryviailvvvlmvlgvfqlgiigrlidsffnylfgysryltyilvllatgfityskripktrrtagsivlqiallfvsqlvfhfnsgikaerepvlsyvyqsyqhshfpnfgggvlgfyllelsvplislfgvciitilllcssvilltnhqhrevakvalenikawfgsfnekmsernqekqlkreekarlkeeqkarqneqpqikdvsdftevpqerdipiyghtenesksqsqpsrkkrvfdaenssnnivnhhqadqqeqiteqthnsvesentieeagevtnvsyvvppltllnqpakqkatskaevqrkgqvlentlkdfgvnakvtqikigpavtqyeiqpaqgvkvskivnlhndialalaakdvrieapipgrsavgievpnekislvslkevldekfpsnnklevglgrdisgdpitvplnemphllvagstgsgksvcingiitsillnakphevklmlidpkmvelnvyngiphllipvvtnphkaaqalekivaemerrydlfqhsstrnikgynelirkqnqeldekqpelpyivvivdeladlmmvagkevenaiqritqmaraagihlivatqrpsvdvitgiiknnipsriafavssqtdsrtiigtggaekllgkgdmlyvgngdssqtriqgaflsdqevqdvvnyvveqqqanyvkemepdapvdksemksedalydeaylfvveqqkastsllqrqfrigynrasrlmddlernqvigpqkgskprqvlidlnndev |
335. | maeklqrelsnrhiqliaiggaigtglflgagqtialtgpsilltyiiigfmlfmfmrglgeiiiqntefksfadvtntyigpfagfvtgwtywfcwiitgmaevtavakyvsfwfpeipnwisalfcvlllmsfnllsarlfgelefwfsiikiatiiglivvgfvmilfafktqfghasftnlyehgifakgasgffmsfqmalfsfvgiemigvtagetkdpvktipkainsvpirilifyvgalavimsiipwqqvdpdnspfvklfaligipfaaglinfvvltaaasscnsgifsnsrmlfglssqqqappnfsktnkygvphvaifassalllvaallnyifpdatkvftyvttistvlflvvwgliiiayinysrknpdlhknatykllggkymgylifvffifvfgllfinvdtrraiyfipiwfillafmylrykriaaksnk |
336. | mnllkknkysirkykvgifstligtvlllsnpngaqalttdnnvqsdtnqatpvnsqdkdvannrglansaqntpnqsattnqatnqalvnhnngsivnqatptsvqsstpsaqnnnhtdgnttatetvsnannndvvsnntalnvptktnengsgghltlkeiqedvrhssnkpelvaiaepasnrpkkrsrraapadpnatpadpaaaavgnggepvaitapytpttdpnannagqnapnevlsfddngirpstnrsvptvnvvnnlpgftlinggkvgvfshamvrtsmfdsgdnknyqaqgnvialgrihgtdtndhgdfngiekaltvnpnselifefntmttkngqgatnviiknadtndtiaektveggptlrlfkvpdnvrnlkiqfvpkndaitdargiyqlkdgykyysfvdsiglhsgshvfverrtmdptatnnkeftvttslknngnsgasldtndfvyqvqlpegveyvnnsltkdfpsnnsgvdvndmnvtydaanrvitikstgggtansparlmpdkildlryklrvnnvptprtvtfnetltyktytqdfinsaaeshtvstnpytidiimnkdalqaevdrriqqadytfasldifnglkrraqtildenrnnvplnkrvsqayidsltnqmqhtlirsvdaenavnkkvdqmedlvnqndeltdeekqaaiqvieehkneiignigdqttddgvtrikdqgiqtlsgdtatpvvkpnakkairdkatkqreiinatpdvtedeiqdalnqlatdetdaidnvtnattnadvetaknngintigavvpqvthkkaardainqatatkrqqinsnreatqeeknaalneltqatnhaleqinqattnadvdnakgdglnainpiapvtvvkqaardavshdaqqhiaeinanpdatqeerqaaidkvnaavtaantnilnantnadveqvktnaiqgiqaitpatkvktdaknaidksaetqhntifnnndatleeqqaaqqlldqavatakqninaadtnqevaqakdqgtqnivviqpatqvktdtrnvvndkareaitninattgatreekqeainrvntlknraltdigvtsttamvnsirddavnqigavqphvtkkqtatgvlndlatakkqeinqntnatteekqvalnqvdqelatainninqadtnaevdqaqqlgtkainaiqpnivkkpaalaqinqhynaklaeinatpdatndeknaaintlnqdrqqaiesikqantnaevdqaatvaennidavqvdvvkkqaardkitaevakrieavkqtpnatdeekqaavnqinqlkdqainqinqnqtndqvdtttnqavnaidnveaevvikpkaiadiekavkekqqqidnsldstdnekevasqalakekekalaaidqaqtnsqvnqaatngvsaikiiqpetkvkpaarekinqkanelrakinqdkeataeerqvaldkinefvnqamtditnnrtnqqvddttsqaldsialvtpdhivraaardavkqqyeakkreieqaehatdeekqvalnqlannekralqnidqaianndvkrvetngiatlkgvqphivikpeaqqaikasaenqvesikdtphatvdeldeanqlisdtlkqaqqeientnqdaavtdvrnqtikaieqikpkvrrkraaldsieennknqldairntldttqderdvaidtlnkivntikndiaqnktnaevdrtetdgndnikvilpkvqvkpaarqsvgvkaeaqnalidqsdlsteeerlaakhlveqalnqaidqinhadktaqvnqdsinaqniiskikpattvkatalqqiqniatnkinlikanneatdeeqniaiaqvekelikakqqiasavtnadvayllhdekneireiepvinrkasareqlttlfndkkqaieaniqatveernsilaqlqniydtaigqidqdrsnaqvdktaslnlqtihdldvhpikkpdaektinddlarvtalvqnyrkvsnrnkadalkaitalklqmdeelktartnadvdavlkrfnvalsdieavitekensllridniaqqtyakfkaiatpeqlakvkvlidqyvadgnrmidedatlndikqhtqfivdeilaiklpaeatkvspkeiqpapkvctpikkeethesrkvekelpntgsegmdlplkefalitgaallarrrtknekes |
337. | msveiesieheleesiaslrqagvritpqrqailrylisshthptadeiyqalspdfpnisvatiynnlrvfkdigivkeltygdsssrfdfnthnhyhiiceqcgkivdfqypqlneierlaqhmtdfdvthhrmeiygvckecqdk |
338. | msekqqildyietnkysyieishriherpelgneeifasrtlidrlkehdfeieteiaghatgfiatydsgldgpaigflaeydalpglghacghniigtasvlgaiglkqvidqiggkvvvlgcpaeeggengsakasyvkagvidqidialmihpgnetyktidtlavdvldvkfygksahasenadealnaldamisyfngvaqlrqhikkdqrvhgvildggkaaniipdytharfytramtrkeldiltekvnqiargaaiqtgcdyefgriqngvnefiktpklddlfakyaeevgeavidddfgygstdtgnvshvvptihphikigsrnlvghthrfreaaasvhgdealikgakimalmglelitnqdvyqdiieehahlkgngk |
339. | mtttfiisyiilaliivgvinlflirsrkkgkrqqkeqqfttrqsnqskfkasdldkttdqstqrmtheelrvdnqddhsqvslngytkgsekdqeaftnnkdeeavaaknpeseeykvnekikkehknfifgegvsrgkilaallfgmfiailnqtllnvalpkintefnisastgqwlmtgfmlvngilipitaylfnkysyrklflvalvlftigslicaismnfpimmvgrvlqaigagvlmplgsiviitiyppekrgaamgtmgiamilapaigptlsgyivqnyhwnvmfygmfiigiiailigfvwfklyqyttnpkadipgiifstigfgallygfseagnkgwgsveietmfaigiifiilfvirelrmkspmlnlevlkfptftlttiinmvvmlslyggmillpiylqnlrgfsaldsgllllpgslimgllgpfagklldtiglkplaifgiavmtyatweltklnmdtpymtimgiyvlrsfgmafimmpmvtaainalpgrlashgnaflntmrqlagsigtailvtvmttqttqhlsafgeeldktnpvvqdhmrelasqyggqegamkvllqfvnklatvegindafivatifsiialilclflqsnkkakataqkldadnsinhe |
340. | miknkiltatlavgliaplanpfieiskaenkiedigqgaeiikrtqditskrlaitqniqfdfvkdkkynkdalvvkmqgfissrttysdlkkypyikrmiwpfqynislktkdsnvdlinylpknkidsadvsqklgyniggnfqsapsiggsgsfnysktisynqknyvtevesqnskgvkwgvkansfvtpngqvsaydqylfaqdptgpaardyfvpdnqlppliqsgfnpsfittlshergkgdksefeitygrnmdatyayvtrhrlavdrkhdafknrnvtvkyevnwkthevkiksitpk |
341. | mqstktktkhfsflllitlgvmtafgpltidmyvpslpkvqgdfgsttseiqltlsftmiglalgqfifgplsdafgrkriavsiliifilvsglsmfvdqlplfltlrfiqgltgggviviakasagdkfsgnalakflaslmvvngiitilaplagglalsvatwrsiftiltivaliiligvasqlpktskdelkqvnfssvikdfgsllkkpafiipmllqgltyvmlfsyssaspfitqklynmtpqqfsimfavngvgliivsqvvallveklhrhilliiltiiqvvgvaliiltltfhlplwvlliafflnvcpvtsigplgftmameertggsgnassllglfqfilggavaplvglkgefntspymiiifitaillvslqiiyfkmikkqhva |
342. | mmygypekwlegmttgegiaaelrlgivnghiaegtlltenqmakqfnvsrspirdafkllqqnqliqlermgahvlpfgeqekkemydlrlmlesfafsrvknqerlpivkemkkqlemmkvavkfedaesftkhdfefhetlikasnhqylnsfwshlkpvmmalvltsmrqrmqqnpgdferihhnhqvfidaveqydsqilkeafhlnfddvgkdiegfwln |
343. | mgsffnkiarkedpaiyqnkdghlkrtlrvrdflalgvgtivstsiftlpgivaaehagpavalsfllaaivaglvaftyaemaaampfagsayswvnvlfgeffgwvagwallaeyfiavafvasgfsanlrglvkpigielpaalsnpfgtnggfidiiaaivilltalllsrgmseaarmenilvilkvlaiilfvivgltainvsnyvpfipehkvtatgdfggwqgiyagvsmiflayigfdsiaansaealdpqktmprgilgslsvaivlfiavalvlvgmfhysqyannaepvgwalrqsghgvvaaivqaisvigmftaligmmlagsrllysfgrdgllpswlshlndkhlpnralviltiigvligsmfpfaflaqlisagtlvafmfvslamyrlrkregkdlpipafklplypvlpaitfvlvllvfwglgfeaklytliwfivgiilylsyglrhskkndvaeyhppk |
344. | mnsdnmwltvmgliiiisivglliakkinpvvgmtiipclgamilgysvtdlvgffakgldqvinvvimfifaiiffgimndsglfkplvkrlilmtrgnvvivcamtaligtiaqldgagavtfllsipallplykalnmnkyllilllalsaaimnmvpwggpmarvaavlkaksvnelwyglipiqiigfilvmlfavylgfkeqkrikkaiernelpqtqdidvhklvevyerdqdvrfpvkgrartkswikwvntaltlavilsmliniappefafmigvslalvinfksvdeqmerlrahapnalmmaaviiaagmflgvlnetgmlkaiatnlikvipaevgpylhiivgllgvpldlltstdayyfavlpiveqtagqfgvpsvstaysmvigniigtfvspfspalwlaiglaeanmgtyikyaffwiwgfaivmlviamlmgivti |
345. | mentvkyrkfilpivvglliwaltpfkpdavdptawymfaifvatiiacitqpmpigavsiigftimvlvgivdmktavagfgnnsiwliamaffisrgfvktglgrrialhfvklfgkktlglaysivgvdlilapatpsntaraggimfpiikslsesfgskpkdgsarkmgaflvftefqgnlitaamfltamagnplaqnlasstsnvhitwmnwflaalvpglvslivvpfiiykiypptvketpnakswaenelatmgkialaekfmigifvvaltlwivgsfihidatltafialalllltgvltwqdilnetgawntlvwfsvlvlmadqlnklgfipwlsksiatslgglswpivlvililfyfyshylfasstahisamyaallgvaiaagapplfsalmlgffgnllastthyssgpapilfssgyvtqkrwwtmnlilgfvyfiiwiglgslwmkvigif |
346. | mnkvikmlvvtlafllvlagcsgnsnkqssdnkdkettsikhamgtteikgkpkrvvtlyqgatdvavslgvkpvgaveswtqkpkfeyikndlkdtkivgqepapnleeisklkpdlivaskvrnekvydqlskiaptvstdtvfkfkdttklmgkalgkekeaedllkkyddkvaafqkdakakykdawplkasvvnfradhtriyaggyageilndlgfkrnkdlqkqvdngkdiiqltskesiplmnadhifvvksdpnakdaalvkktesewtsskewknldavknnqvsddldeitwnlaggyksslkliddlyeklniekqsk |
347. | minqsiwrsnfrilwlsqfiaiagltvlvpllpiymaslqnlsvveiqlwsgiaiaapavttmiaspiwgklgdkisrkwmvlrallglavclflmalcttplqfvlvrllqglfggvvdassafasaeapaedrgkvlgrlqssvsagslvgpliggvtasilgfsallmsiavitfivcifgalklietthmpksqtpninkgirrsfqcllctqqtcrfiivgvlanfamygmltalsplassvnhtaiddrsvigflqsafwtasilsaplwgrfndksyvksvyifatiacgcsailqglatnieflmaarilqgltysaliqsvmfvvvnachqqlkgtfvgttnsmlvvgqiigslsgaaitsyttpattfivmgvvfavsslflicstitnqindhtlmklwelkqksak |
348. | mkrlfdvvssiyglvvlspillitallikmespgpaifkqkrptinnelfniykfrsmkidtpnvatdlmdstsyitktgkvirktsidelpqllnvlkgemsivgprpalynqyeliekrtkanvhtirpgvtglaqvmgrdditddqkvaydhyylthqsmmldmyiiyktiknivtsegvhh |
349. | maqlnskiaslklfasyaiatyilviltsalnlfkgyvadtfyiaetllivltiiliiiltteqtwkhhdlwrrivevllllmtltgnvftllmfvsirryqrtsqihsyngwesfirkttrhriaiigllilvymltlsivsqftfdttlatknqfnallhgpslaypfgtddfgrdlftrvvvgtkltfsisiisvviavifgvllgtiagyfnhidnlimrildvvfaipslllavaiiasfgasipnliialsignipsfartmrasvleikrmeyvdaaritgentwniiwryilpnaiapmivrfslnigvvvlttsslsflglgvapdvaewgnilrtgsnylethsnlaivpgvcimfvvlafnfigdavrdaldprih |
350. | mktihlfriyhsfllkkwyliiyllfilaallitlttiqhvteddnhfnigvvdkdqssetklilnsigkgsnlgknvsikayddkqahtllkkhklqgyfvfdkgmtkafykqgelpisvytydqqsmksvvlsqltdsvyqrlmrsmggilafqdlapkashsdsinvmtdllitglnrsgafnlepihlydtgsyyaitgflttvfifalslftvlkmnqdtvlkarlkmfhfskerlliirtlitwfytmlwsivgvvwivfsipnifelynwptlaihlsyyvtflilwllliellttgllnsiskvilaivilvlsgltiptiflqhiangvfniqpfavvtnqlleiilnnyilelhpsfylsfialliinlavlvwryrg |
351. | mkkqviisglmlfslffgagnlifppmlghtagqnmwigmlgfaltgillpfitvivvafydegvesvgnrihpwfgfifavviymsigafygipraanvayeigtrhilpvhnqwtliifaaiffaivywislnpskivdnlgklltpllllmvallsiavifnpesalsapkdkyithpfisgslegyftmdlvaalafsvvivngykfkgltdrmkilkyvcfsgliaaillgmiyfalayvgastapgnfkdgtdiltynslrlfgsfgnlvfgmtvilaclttciglvnacatftkkhvpkfsykifalifsiigflfttlglemilkiavplltliypvsialvlisfanmfstfrfswayrlatvitliisilqilnsfnllhgvilksfmmlpladidlawlvpfmlfaiigfiidvfirrpkqatt |
352. | mkhyltkfvamlitaamvcsfgllksqaaeqqsisdvysvitdaksalsnnsisndnkqkaieqvvsavkklslednsesnavksdvrkledakandnqkdtlsqltksliayeeklaskdagskikllqqqvdakdaamtkaikdknkaeleslnnslnqiwtsnetvirnydanqygqievallqlriaihkspldtakvshawttfksnidhvdkksntsandqyhvsqlndalekaikaiddnqlsdadaalthfietwpyvegqiqtkdgalytkiedkipyyqsvldehnkahvkdglvdlnnqikevvghsysfvdvmiiflreglevllivmtlttmtrnvkdkkgtasviggaiaglvlsiilaitfvetlgnsgilresmeaglgivavilmfivgvwmhkrsnakrwndmiknmyanaisngnlvllatiglisvlregveviifymgmigelatkdfiigialaiviliifallfrfivklipifyifrvlsififimgfkmlgvsiqklqllgamprhviegfptinwlgfypsyepliaqgayimvvailifkfkk |
353. | atgaagaatttttctaaattcgcacttacaagtattgccgcattaactgtggcaagtcctttagtcaatacggaggttgacgctaaggataaagtatcagcaactcaaaacatcgatgcgaaagtaacccaagaatctcaagcaactaacgcattgaaagagttaccaaaatctgaaaatataaaaaagcattacaaagattataaggtcactgatactgaaaaagataacaaaggatttacgcattacacattgcaaccgaaagtgggcaacacgtatgcaccagacaaagaagtaaaagttcatacgaataaagagggtaaggtagttcttgtcaatggtgatactgatgctaagaaagttcaacctacgaataaggtagcgataagtaaagaaagtgccacagataaagctttcgaagcaataaaaattgaccgtcaaaaagctaaaaacttaaaaagtgatgtcatcaaaaccaataaagttgagattgatggagaaaaaaataaatatgtttataacatagaaattattacaacttcaccaaaaatctctcattggaatgtgaaaattgacgctgaaactggtcaagtggttgataaattaaatatgatcaaagaagcagctactacaggtacaggtaaaggtgtactaggtgacacgaaacaaattaatattaatagtgtcagcggtggttatacactacaagatttaactcaacaaggtacactttcagcttacaattacgatgcgaatactggtcaagcttacttaatgcaagataaagataaaaattttgttgatgatgaacaacgtgcaggtgtagatgcaaattattatgctaaagaaacgtatgactattataaaaatactttcggccgagaatcatatgataatcaaggtagcccaattatttcaatcgcacatgtaaataacttccaaggtcaagataacagaaacaatgcagcttggattggtgataaaatgatttacggtgacggtgatggacgtacatttacagcgttgtctggtgcgaatgatgttgttgcacatgaaattacacatggtgtaacacagcaaactgctaatcttgtttaccgttctcaatcaggtgcattaaatgaaagtttttcagatgtatttggttacttcattgatgatgaagatttcttaatgggtgaagatgtttacacacctggtgtaggcggagatgccttaagaagtatgtctaatccagagcgttttggacaaccatctcatatgaatgattttgtttatacaaattctgacaacggaggcgtacatacgaattcaggtattccgaacaaagcagcttacaacacaattcgtagtattggtaaacaacgttctgaacaaatttattatagagcgttaactgtttatttaacttcaaattctgatttccaagatgccaaagcatcattacaacaagcagcatttgatttatatggcgacggtattgctcaacaagtaggtcaagcatgggacagtgttggcgtg |
354. | atgtctaaacatagtgctacgttagttattatgtttttaataactttattgcctatttttcaatatcaagcttctgcacatgcgactttagaaaaatcaacaccacaacagcaaggggttattaaagacaaaccagaagcaatcaagttagagtttaatgaacctgtgaacaccaaatactcgagtgtgaccttatttgatgataaaggtaaaaagattaaagaccttaaaccaataacaactggatggtctcagacagttgtattttcatctgagcaaattgttaatggcacgaatactattgaatggcatacggtatctgcggatggacatgaagtcggagatacgtttgaattttcagttggaaaagtgaggctaaagatg |
355. | atgaaaaaaatcaaaacaatctcgacattggtagctggacttggtatagcatttctaggtcacacaacacatgcagatgcggctgaaaataacaatcaacaacaaagtacatataactatagtacaactgaagtatcattttctaattcaggaaatttatatacttctggccaatgtacttggtatgtttatgataaaactggtggaaaaatcggatcaacatgggggaatgcaaatagctgggcaactgcagctcaagcagcaggattcactgtaaataatacacctgaagaaggtgcaattatgcaatcatctgaaggtgctttcggacatgttgctttcgttgaaagtgtcaataatgatggttctattactgtatcagaaatgaactatgatggtggtccattcgctataagcacacgaacaatctctgccagtgaagcaagttcatataattacatccacctgaat |
356. | atgaaaaaaatcgctacagctacaattgcaactgcaggaatcgctactttcgcatttgcacaccatgacgcacaagcagcagaacaaaataatgatgggtacaatccaaacgacccttattcatatagctacacttacacaatcgatgctgaaggtaactaccactacacttggaaaggtaactggagtccagatcgtgtaaatacttcatataactataataattataataactacaactactatggttacaataactatagcaactacaataactacagtaattacaacaattacaacaactatcaatcaaacaacacgcaatcacaaagaacaactcaaccgactggtggtttaggcgcaagctattcaacatcaagtagtaatgttcacgttacaacaacttctgcgccatcatcaaacggtgtatctttatcaaacgctcgctcagcatctggtaacttatacacttcaggtcaatgtacatattatgtatttgacagagtaggtggcaaaatcggttcaacgtggggtaacgcaaacaactgggcaaacgctgcagcacgttctggttacacagtaaacaattcacctgctaaaggtgcaatcttacaaacgtcacaaggtgcatacggacacgtagcatacgttgaaggtgtaaacagcaatggttcaatcagagtttcagaaatgaactacggtcacggtgcaggtgttgtcacttcacgtacaatctctgcgagtcaagctgcttcatataactatattcac |
357. | ttggaagataaaaaagctccagtaaatgaagactttttaaattacatcaaaaactatgccgatgtaagaaacatacctctttcaagacgtaagatggcctcgttgtttcacacttctaaaactgcaattgatgatgtctcacaagaaaaactaaatacttggttacgaaaacctgataagttttacgtgaatattatcgagctttcgaaagacttatattacaagtctggtgaatatcgtagcttacttaattactttattgatatggctcgtttctattatgtgattgatccattgtttagcagcgatagtaagatgagcaaggagaaagtcaaaaaagacctctctaaaatatctttacaacttaataaaatgaatttaaaacatgagttagctaaaatttacaaaacatgtgtacttgaagatattttctttggttatgaaatcgaagataaagacaattacttcatgttaaaacttgatccaaagtattgtaaattagttggtatctctgacgggatgtatacatatgctttcaacctgtcctattttgacggtaatttagatttattaaaaacattcccagaagagtttcaaagagcatatttagaacgctctattgataagcaagctgacttaaattggtttattccagacttcactaaatcagttgttttcaaaattaatgaagacgatcctactattttacctccattttctacaatgtttgaacccctattagatttaaacgattataaaaagcttaaaaaagctggagctaaaattaataactacatgttattacatcaaaaagtgccaatgcatgataatgcaaataaagattatcaagctgataacttcgcaatctcagctgaggcaatggactacttcagcgagttagttaacgaaaacttaccagatgaaattggttctatcgtttcccctatggaagttaaccctattaaattagatagagatgataaaactgataaggtacttgaagctactagagatgtttataacgcttctggtgtttcttcatttatctttaacaatgataaaaactctactggtggtttaacttactcagttcgtaaagatgagttattcgtaattaatttctaccgacaagttgagagatggttaaatcgtaaaatcagatatggcaatatcgtagccaaaaatcaatggagaatttctctattaaatgtaactggaatgagtgaagatacttacttagagcaattaactaagtctggtacattcggtttctcagttagaggacgtattgctgcattacatggtttagattaccatacattatctcaaagtttagaattagaaaacaatatcttagatttagatactaatttaatacctcttgctsgttctcatactggtggtttaaatactgctgttgaacaaacaaaaggaaaaatagaagactctggtggcagacctactaaagaaactaaagacttgtctgatagcggacaagcaaatcgtgactctagtaattctgagacaaaatctttagaaggtggtgacactaataatgaa |
358. | gtgggagtcgtgtcaatcattactgggattacaatatttgtcagtggtcagcatgctcaagctgctgaaatgacacaatcatcatcagattctaacgaacagtcacaacaaacagaacaagttgaacacaaagaagatacaactcatttatcttacgaattgaatcaagagggtgagacagcgagccaatcaaagactagtcaagagaatcaatctgatggcaatgtacaaaaaaagagtaatcaaatacaacaagattcaacacaaacgtcaccattaaatgaccaaaaacaaacttcaatggaacaacaatcaaaagacaatcatgttaccccaaattcacgtcaggatacatatccaaaaggccaaaatcaagatgataaaggcaaacaacagtttaaagataatcaacactcacaaacagaacatcaacctaatactcaaaaccaaaataatgatcaagattcatcagataaaaagcaacacccatctgatcaaactcaagactcatcttcaaaaggaacacaacctaaacaatcacagtctatagaagatagagataaaacagtaaaacaaccatcttctaaagtacacaaaataggtaacacaaaaactgataaaacagttaaaacaaatcaaaaaaagcaaacatcattaacttcaccacgcgttgtgaaatcaaaacaaactaaacatatcaatcaacttactgcgcaagctcaatataaaaatcaatatccagtcgtgtttgtacatggatttgtaggtttagtcggtgaagatgcattcagcatgtacccaaattattggggtggtactaaatataacgtgaaacaagaacttacaaaattaggttaccgagttcacgaagccaatgtaggggcatttagcagcaattatgaccgtgctgttgaactgtattattatattaaaggtggaagagtagattatggtgcagcacatgctgcaaaatatggtcacaagcgttatggcagaacatatgaaggcatcatgcctgattgggaaccaggtaaaaagatacatcttgttggacatagtatgggtggccaaacgatacgcttgatggaacattttttaagaaatggaaatcaagaagaaatagattatcaacgtcaatatggtggtacggtatccgatttatttaaaggtggacaagataatatggtgtctacgattactacattaggaacgcctcataatggcacacctgctgcagataaactagggtcgactaaatttattaaagatacaattaatagaattggaaaaattggtggaactaaagcgctcgatttagaactaggtttttctcaatggggcttcaaacagcaacctaatgaatcatatgctgaatatgcaaaacgtatagcgaatagtaaagtttgggagactgaagatcaggctgtaaatgatttaacaactgctggagcagaaaagttaaaccaaatgacgacattgaatcctaatatcgtctatacatcatatacaggtgctgcaacacatactggaccattaggcaatgaagtgccgaatattagacaattcccactattcgatttaacaagtcgtgtgataggtggagatgataataaaaatgtcagagtaaatgatggcatagtacctgtgtcttcttcactacatccaagtgatgaagcatttaagaaggtaggtatgatgaacctagcaactgacaagggtatctggcaagtgagacccgtacaatatgattgggatcatctagatttagtcggcttagatactactgattataagcgaactggagaagaattaggtcaattctatatgagtatgataaataatatgttgaaagtcgaagagttagatggtattacacgtaag |
359. | mknfskfaltsiaaltvasplvntevdakdkvsatqnidakvtqesqatnalkelpksenikkhykdykvtdtekdnkgfthytlqpkvgntyapdkevkvhtnkegkvvlvngdtdakkvqptnkvaiskesatdkafeaikidrqkaknlksdviktnkveidgeknkyvynieiittspkishwnvkidaetgqvvdklnmikeaattgtgkgvlgdtkqininsvsggytlqdltqqgtlsaynydantgqaylmqdkdknfvddeqragvdanyyaketydyykntfgresydnqgspiisiahvnnfqgqdnrnnaawigdkmiygdgdgrtftalsgandvvaheithgvtqqtanlvyrsqsgalnesfsdvfgyfiddedflmgedvytpgvggdalrsmsnperfgqpshmndfvytnsdnggvhtnsgipnkaayntirsigkqrseqiyyraltvyltsnsdfqdakaslqqaafdlygdgiaqqvgqawdsvgv |
360. | mskhsatlvimflitllpifqyqasahatlekstpqqqgvikdkpeaiklefnepvntkyssvtlfddkgkkikdlkpittgwsqtvvfsseqivngtntiewhtvsadghevgdtfefsvgkvrlkm |
361. | mkkiktistlvaglgiaflghtthadaaennnqqqstynysttevsfsnsgnlytsgqctwyvydktggkigstwgnanswataaqaagftvnntpeegaimqssegafghvafvesvnndgsitvsemnydggpfaistrtisaseassynyihln |
362. | mkkiatatiatagiatfafahhdaqaaeqnndgynpndpysysytytidaegnyhytwkgnwspdrvntsynynnynnynyygynnysnynnysnynnynnyqsnntqsqrttqptgglgasystsssnvhvtttsapssngvslsnarsasgnlytsgqctyyvfdrvggkigstwgnannwanaaarsgytvnnspakgailqtsqgayghvayvegvnsngsirvsemnyghgagvvtsrtisasqaasynyih |
363. | ledkkapvnedflnyiknyadvrniplsrrkmaslfhtsktaiddvsqeklntwlrkpdkfyvniielskdlyyksgeyrsllnyfidmarfyyvidplfssdskmskekvkkdlskislqlnkmnlkhelakiyktcvlediffgyeiedkdnyfmlkldpkycklvgisdgmytyafnlsyfdgnldllktfpeefqraylersidkqadlnwfipdftksvvfkineddptilppfstmfeplldlndykklkkagakinnymllhqkvpmhdnankdyqadnfaisaeamdyfselvnenlpdeigsivspmevnpikldrddktdkvleatrdvynasgvssfifnndknstggltysvrkdelfvinfyrqverwlnrkirygnivaknqwrisllnvtgmsedtyleqltksgtfgfsvrgriaalhgldyhtlsqslelennildldtnliplasshtgglntaveqtkgkiedsggrptketkdlsdsgqanrdssnsetksleggdtnne |
364. | vgvvsiitgitifvsgqhaqaaemtqsssdsneqsqqteqvehkedtthlsyelnqegetasqsktsqenqsdgnvqkksnqiqqdstqtsplndqkqtsmeqqskdnhvtpnsrqdtypkgqnqddkgkqqfkdnqhsqtehqpntqnqnndqdssdkkqhpsdqtqdssskgtqpkqsqsiedrdktvkqpsskvhkigntktdktvktnqkkqtsltsprvvkskqtkhinqltaqaqyknqypvvfvhgfvglvgedafsmypnywggtkynvkqeltklgyrvheanvgafssnydravelyyyikggrvdygaahaakyghkrygrtyegimpdwepgkkihlvghsmggqtirlmehflrngnqeeidyqrqyggtvsdlfkggqdnmvstittlgtphngtpaadklgstkfikdtinrigkiggtkaldlelgfsqwgfkqqpnesyaeyakrianskvwetedqavndlttagaeklnqmttlnpnivytsytgaathtgplgnevpnirqfplfdltsrviggddnknvrvndgivpvssslhpsdeafkkvgmmnlatdkgiwqvrpvqydwdhldlvgldttdykrtgeelgqfymsminnmlkveeldgitrk |
365. | tcaataaggtgctttctaaagaatttttctccccatgtccaatctataaataaatctttggttaaaaattgcgacacaaccattctcattcgattatgcataaaaccagtttgtgtcaattccattattgctgcatcaatgattggaaatcctgtttgcccttcgcaccatgcattaaaatccgcttcattttgcgaccattttatctgtcgatatttaggtttgaaagcttggtatgaggtttcaggatactgtgtcattaacacataa |
366. | ctgttgcaccatttggtccttttgcacctaagtcaattgatacttgcccagttgccatatcaggaattaacattggtacgaaaaatggactcacacgtcttgggcctttatccattaattgtttatgtgcaatttcaaatgtttccataccaccgataccagaaccaatccatacaccgattcgatctgcagtattttcat |
367. | gatgcacctttaggtctaatacctggtgttacttttaaaaatgatgtacctaacttttcagtcaacatacgactttcaagaggtgaacaaacaacgccatctaaaccagccgcatttgctaacttggcataa |
368. | tacatcaaaccactatgtttacccattttcttaccatcaagtgttatcatatcacccggttgtgcaggtaaatattgtgataaaaatgttttaaagtttttttcgccgataaaacaaatgcctgtagaatcttttttcttagcagtaacaagtccttgttcttcagcaattcgacgcacttcactcttttcgatgtcgccaattgggaacatcacttttgaaagttgttgt |
369. | cgtttcgcatcttcatcatattctaataatggccaatctgtcacccataagaagtttaattttgtttcatcgattaaacctaattctttagctaatttgacacgtaatgcacctaaactttgtgcaacgacatttggtttgtctgcaacaaacattactaagtcaccagcttcagcaccagttaatgtaagtaatgtttcaacattttctgtttcaaagaaacgtccaattggacctgtcaaaccatcttccacaactttaacccacgctaatcctttagcacca |
370. | cgtcaacgtcctgtccatgtgtttccaaaaaataataatccacatgggcaatataatcatcaatatcaacatcactacgtaacgctagcaaatgctttt |
371. | atgaatgaagcatctaatttaatcttaaccatgccaaatgaatccaaagccgcaactaaaatagcaaagattaagccgccaatcactggtgctggtatacaaatacgttttaaaaaattaacg |
372. | attctatcagccgcattatccacaccggcattattaaacaacacatcgattcttccaaactgttcctttatgtcagacacaaagtctaccacttgttgttcgcttgcattatccacattatacgccttcgcattgtcaccattacttttaattttatcgacagtctccgataccgcttcagctatgtctaccgccaatacatacgcaccttat |
373. | cctggcgctattgtttcaggtccgtattctgttaattcattaatcggatcttttgtaatctcttcttttggttcacctttactaataattactccagttaatggattttttagtgttggtgtcgttattgtcttctcacctttttgtccttctcttgttactttttctgtccctggtgctaaatccggattaaatttacgttctttcttgaatggaatctcttcaacttttttttctaattctgttattgtttttggcgcttctggtgtaaaagtaaactctgaacctttcaagtcagttctcatccagccatttgcatttatccct |
374. | ttactaacatttattgctgttaaacctacgatgacaaataaaataatagctaatacttttaaaataactaaaatattttccatacgagctgcttccgacataccacgtgatagtaataatgcagttaataaaataacgatagcagcaataatatcgataaaaccgccatttgtaccaaatggatttgataatgctgcaggtaattcgatgccaattggtttcacaagtccgcgtaaattcgctgagaatcctgatgcaacaaaggctacggcgataaaatattcagctaatagagcccaaccggcaacccatccaaaaaattcaccaaataatacattgacccaagaa |
375. | gatgtgttgaaactgagttcaattaaattatatgtttttattatacactttttgacatattttttaaatttaagaatgcgaagatttttaacatttctgatgctagctttctttttcatctttcaaatgcttaataaaatcaaagccaggtcgccctttagccaatgcttccatcacatcataccaatccgaaccgacttgttgatatatattttgcaa |
376. | tctatcattgtaaatactgtatctaagtgcataaaagttcgactagttggaatttcaattgctactacttttttaaacgtcgcctgcggattttcaaaaatacgtcgcgctaacttttcaatagcttgtgcagatgtacgttctgaaacgcctatagccaagacatctttagataaaacaagttcatcgccgccttcaatattgaatgggcaatctcgatctaaccagattggaatattcgcatctttaaatctagga |
377. | gaagtcttggccattcccttgagtaaacatgaagccccagccatctgctcctgttgtattaccttggttgttgtttgctactggaacagtaattgtaaagtctttattaaaatctattttatcattatattctaa |
378. | sircflknfsphvqsinkslvkncdttilirlcikpvcvnsiiaasmignpvcpshhalksasfcdhficrylglkawyevsgycvint |
379. | llhhlvllhlsqlilaqlpyqeltlvrkmdshvlglyplivyvqfqmfpyhryqnqsihrfdlqyfh |
380. | daplglipgvtfkndvpnfsvnirlsrgeqttpskpaafanla |
381. | yikplclpiflpssviispgcagkycdknvlkffspikqmpvesfflavtspcssairrtslfsmspignitfescc |
382. | rfasssysnngqsvthkkfnfvssikpnslanltrnapklcattfglsatnitkspasapvnvsnvsttsvskkrpigpvkpssttlthanplap |
383. | rqrpvhvfpknnnphgqynhqyqhhyvtlanaf |
384. | mneasnliltmpneskaatkiakikppitgagiqirfkklt |
385. | ilsaalstpallnntsilpncsfmsdtksttccslalstlyafalsplllilstvsdtasamstantyapy |
386. | pgaivsgpysvnsligsfvissfgsplliitpvngffsvgvvivfspfcpslvtfsvpgaksglnlrsflngisstffsnsvivfgasgvkvnsepfksvliqpfafip |
387. | lltfiavkptmtnkiiantfkitkifsiraasdiprdsnnavnkitiaaiisikppfvpngfdnaagnsmpigftsprkfaenpdatkataikysanraqpathpknspnntltqe |
388. | dvlklssiklyvfiihfltyflnlrmrrfltflmlafffifqmlnkikarspfsqcfhhiipirtdlliyilq |
389. | siivntvskcikvrlvgisiattflnvacgfskirranfsiacadvrsetpiaktsldktsssppsilngqsrsnqigifaslnlg |
390. | evlaiplskheapaicsccitlvvvcywnsnckvfikiyfiiif |
391. | cgttgcacaaagctgaatgttaaaaatgcggatccgccagcaatgactgcaatccaacaatctgatgcgacaccaccaaacataaataggaagaagccacatgcaatggcagctgcaaagaaattcgttaaaaaagaatattgtaatgatgcatgctgtaaa |
392. | rctklnvknadppamtaiqqsdatppninrkkphamaaakkfvkkeycndacck |
393. | atgactaataaaagagaagatgtccgcaatatagcaattattgctcacgttgaccatggtaaaacaactttagtagatgagttgttaaaacaatctggtatattcagagaaaatgaacatgtcgatgaacgtgcaatggactctaacgatatcgaaagagagcgtggaattacgattctagccaaaaatacggctgttgattataaaggtacacgtattaatattttggatacaccaggacatgcagactttggtggagaagtagaacgtattatgaaaatggttgatggggttgtcttagtagtagatgcgtatgaaggtacaatgcctcaaacacgttttgtacttaaaaaagcgctagaacaaaacctgaaacctgttgttgttgttaataaaattgataaaccatcagcacgtccagagggtgttgtagatgaagttttagatttatttattgaattagaagcaaacgatgaacaattagaattccctgttgtttatgcttcagcagtaaatggtacagctagcttagatcctgaaaagcaagatgataatttacaatcattatatgaaacaattattgattatgtaccagctccaattgataacagtgatgagccattacaattccaagtagcattgttggactacaatgattatgttggacgtattggtattggtcgtgtattcagaggtaaaatgcgtgtcggagataatgtatcactaattaaattagacggtacagtgaaaaacttccgtgtaactaaaatctttggttactttggattaaaacgtttagaaattgaagaagcacaagctggagatttaattgctgtttcaggtatggaagacattaatgttggtgaaactgtaacaccacatgaccatcaagaagcattgccagttctacgtattgatgagcctactcttgaaatgacatttaaagttaacaattctccatttgctggccgtgaaggtgactttgtaacagcacgtcaaattcaagaacgtttaaatcaacaattagaaacagatgtatctttgaaagtttctaacacagattctccagatacatgggtagttgctggtcgcggtgaattgcatttatcaatccttattgaaaatatgcgtcgtgaaggttatgaattacaagtttcaaaaccacaagtaattattaaagaaatagatggtgtaatgtgtgaaccatttgaacgtgtgcaatgtgaagtgccacaagaaaatgcaggtgctgttattgaatcattaggtgcacgtaaaggtgaaatggttgatatgactacaactgataatggacttacacgtttaatctttaatgtaccggctcgtggtatgattggttatacgactgaatttatgtcaatgacaagaggttacggtattattaaccatacatttgaagaatttagaccacgtattaaagcacaaattggcggtcgtcgtaatggtgcattaatttcaatggatcaaggttctgcaagtacttatgccattttgggacttgaagatagaggtgtaaacttcatggaacctggtactgaagtttatgaaggtatgattgttggtgaacataatcgtgaaaatgatttaactgttaacatcactaaaacaaaacatcaaactaacgtacgttctgcaacgaaagaccaaacacaaacaatgaatagaccgcgtattctaacattggaagaagcgttacaattcattaatgatgatgaacttgttgtggttacaccagaaagtatacgtttaagaaagaaaattttaaacaaaaatgttcgtgaaaaagaagcaaagcgtatcaaacaaatgatgcaagaaaacgaa |
394. | gtgcttaggagtgatttttatatgtcttattccattgttagagtttcaaaagttaaatctggaacaaatacaacgggcatacaaaaacatgttcaaagagaaaataataattatgaaaatgaagatatagaccatagtaaaacttacttaaattatgatttggtaaatgctaataaacagaattttaataacttgattgatgaaaaaatcgaacagaattatacaggcaaaagaaaaattagaacagacgcgattaaacacattgatggtttaattacatcagacaatgatttctttgataatcaaacgccagaagatacaaagcagttttttgaatatgctaaagagtttttagaacaagaatacggtaaagataatttattatatgcaacagttcacatggacgaaaaaacaccacatatgcattatggcgttgttccaataactgatgatggtcgtttaagtgctaaagaagttgtaggtaataaaaaagctttaacagcgtttcaagatagatttaatgagcatgttaaacaacgaggatatgatttagaacgtgggcaatcaagacaagtaacaaatgctaaacatgagcaaataagtcagtataaacaaaaaacagaatatcataagcaagaatatgaacgtgagagccaaaaaacagaccatataaagcaaaagaacgataaattaatgcaagagtaccaaaaatcgttaaatacgcttaaaaagcctataaatgttccgtatgagcaagaaactgaaaaagtaggtggtttatttagcaaagaaatacaagaaactggaaatgttgtaataagccaaaaagatttcaatgaatttcagaaacagataaaagctgctcaagatatttcggaagattacgagtatataaagtctggtagagccttagatgataaagataaggaaatacgagagaaagatgatttattaaataaagcagttgagcgtattgaaaacgcagacgataattttaaccaactttacgaaaatgcaaagccacttaaagagaatatagaaatagcgttaaagcttttaaaaatcttactaaaagagttagaacgagttttaggaagaaatacctttgcggaaagagttaataagttaacagaagatgaaccaaaacttaatggtttagcaggaaacttagataaaaaaatgaatccagaattatattcagaacaggaacagcaacaagaacaacaaaagaatcaaaaacgagatagaggtatgcactta |
395. | mtnkredvrniaiiahvdhgkttlvdellkqsgifrenehvderamdsndierergitilakntavdykgtrinildtpghadfggeverimkmvdgvvlvvdayegtmpqtrfvlkkaleqnlkpvvvvnkidkpsarpegvvdevldlfieleandeqlefpvvyasavngtasldpekqddnlqslyetiidyvpapidnsdeplqfqvalldyndyvgrigigrvfrgkmrvgdnvslikldgtvknfrvtkifgyfglkrleieeaqagdliavsgmedinvgetvtphdhqealpvlrideptlemtfkvnnspfagregdfvtarqiqerlnqqletdvslkvsntdspdtwvvagrgelhlsilienmrregyelqvskpqviikeidgvmcepfervqcevpqenagavieslgarkgemvdmtttdngltrlifnvpargmigyttefmsmtrgygiinhtfeefrprikaqiggrrngalismdqgsastyailgledrgvnfmepgtevyegmivgehnrendltvnitktkhqtnvrsatkdqtqtmnrpriltleealqfinddelvvvtpesirlrkkilnknvrekeakrikgmmqene |
396. | VLRSDFYMSYSIVRVSKVKSGTNTTGIQKHVQRENNNYENEDIDHSKTYLNYDLVNANKQNFNNLIDEKIEQNYTGKRKIRTDAIKHIDGLITSDNDFFDNQTPEDTKQFFEYAKEFLEQEYGKDNLLYATVHMDEKTPHMHYGVVPITDDGRLSAKEVVGNKKALTAFQDRFNEHVKQRGYDLERGQSRQVTNAKHEQISQYKQKTEYHKQEYERESQKTDHIKQKNDKLMQEYQKSLNTLKKPINVPYEQETEKVGGLFSKEIQETGNVVISQKDFNEFQKQIKAAQDISEDYEYIKSGRALDDKDKEIREKDDLLNKAVERIENADDNFNQLYENAKPLKENIEIALKLLKILLKELERVLGRNTFAERVNKLTEDEPKLNGLAGNLDKKMNPELYSEQEQQQEQQKNQKRDRGMHL |
397. | atgactgttgaagaaagatccaatacagccaaagttgacattttaggggtcgattttgataatacaacaatgttgcaaatggttgaaaatattaaaaccttttttgcaaatcaatcaacgaataatctttttatagtaacagccaaccctgaaatagtgaattacgcgacgacacatcaagcgtatttagagttaataaatcaagcgagctatattgttgctgatgggacaggagtagtcaaagcttcgcatcgtttaaagcaacctctagcgcatcgtatacctggtattgagttgatggatgaatgtttgaaaattgctcatgtaaatcatcaaaaagtatttttgctaggggcaactaatgaagttgtagaagcggcacaatatgcattgcaacaaagatatccaaacatatcgtttgcacatcatcacggttatattgatttagaagatgagacagtagtgaaacgaattaaactgtttaaacctgattacatatttgtaggtatgggattccctaaacaagaagaatggattatgacacatgaaaaccaatttgaatctacagtgatgatgggcgtaggtggttctcttgaagtatttgctggggctaaaaagagagcgccttatatctttagaaaattaaacattgaatggatatatagagcattaatagattggaaacgtattggtagattaaagagtattccaatatttatgtataaaatagccaaagcaaaaagaaaaataaaaaaggcgaaa |
398. | mtveersntakvdilgvdfdnttmlgmveniktffangstnnlfivtanpeivnvatthgaylelinqasyivadgtgvvkashrlkqplahripgielmdeclkiahvnhqkvfllgatnevveaaqyalqqrypnisfahhhgyidledetvvkriklfkpdyifvgmgfpkqeewimthenqfestvmmgvggslevfagakkrapyifrklniewiyralidwkrigrlksipifmykiakakrkikkak |
399. | atgagtgaaaattttaagttacgtaaaatgaaagtcggtttagtatctgttgcaattacaatgttatatattatgacaaacggacaagcagaagcatctgaaaatcaaaacgctttaatctctaatataaatgtagacaatcaggaaaaacagaataatgtaaatcaagctgttcagcctcaaaataatactaatgaaacatcaaaagtaccggctaattttgtcaaattgaatgatattaaaccaggtgatacttctatacaaaggaacaactttaccaaatcaattttactattaactattgataaaaaagatgtgagctcagttgaagattctgacagcagctttgttatgtctgataaagatgggaattttaagtatgacttaaatggtcgcaaaattgttcataatcaagaaattgaagtgtcttcatcagatccctatttaggtgacgatgaagaagatgaagaagtagaagaaacttcaactgaagaagttggtgctgaggaagaaagtacagaagctaaagctacatatacaacaccgcgatatgaaaaagcgtatgaaataccgaaagaacagctaaaagaaaaagatggacatcaccaagtttttatcgaacctattactgaaggttcaggtattattaaaggccatacctctgtaaaaggtaaagttgctctatctattaataataaatttattaactttgagacaaatgctaatggtggtccaaataaagaagaagcgaaatctggatcagaaggaatctggatgcctattgatgacaaaggatactttaattttgacttcaaaacgaaacgtttcgatgatttagagttaaagaaaaatgatgagatctcattaacatttgcacctgatgacgaagatgaggcattgaagtcattaattttcaaaactaaggtaacgagtttagaagatattgataaagcagaaactaaatatgaccatactaaagtggaaaaagtaaaagtattgaaagatgttaaagaagatttacatgtagatgaaatttacggaagcttatatcatacagaaaaaggtaaaggtattcttgataaagaaggtactaaagtaattaaaggtaagactaaattcgcaaatgcagttgtgaaggtagactctgaactaggtgaaggtcaagaattccctgatttgcaagtcgatgraaaaggtgaattcagctttgatgtagatcatgctggatttagattacaaaatggagaaacactaaacttcacagtagttgatcctattacaggtgaattattaagtggaaattttgtttctaaaaacatagatatttatgaatctcctgaagaaaaagcagatcgtgagtttgatgaaagaatggaaaacacacctgcatatcataaattacatggtgataaaattgtcggctacgatactaacggattcccgattacctggttttatccattaggtgaaaagaaagttgaacgtaaggcaccaaaattagaaaaa |
400. | msenfklrkmkvglvsvaitmlyimtngqaeasenqnalisninvdnqekqnnvnqavqpqnntnetskvpanfvklndikpgdtsiqgttlpnqfilltidkkdvssvedsdssfvmsdkdgnfkydlngrkivhnqeievsssdpylgddeedeeveetsteevgaeeesteakatyttpryekayeipkeqlkekdghhqvfiepitegsgiikghtsvkgkvalsinnkfinfetnanggpnkeeaksgsegiwmpiddkgyfnfdfktkrfddlelkkndeisltfapddedealkslifktkvtsledidkaetkydhtkvekvkvlkdvkedlhvdeiygslyhtekgkgildkegtkvikgktkfanavvkvdselgegqefpdlqvdxkgefsfdvdhagfrlqngetlnftvvdpitgellsgnfvsknidiyespeekadrefdermentpayhklhgdkivgydtngfpitwfyplgekkverkapklek |
401. | gtctatatgctatcaagtaccaggtttattgttaggtggtacaacaattgtaataagtccactaatatcattaatgaaagatcaagtggatcaattaaaagcgatgggaattcaagctgcttttttaaa |
402. | vymlsstrfivrwynncnkstniinerssgsiksdgnsscffk |
403. | tttaaatataaaaaaaacagaaaaatacctagtattatgatgcaacaaattaaaattactatactatattcatatttaacgataaataaatgggaataccttcttaacataacaccaaataagaccgtacttcctgccactggccaaaaagaattgattttagctgtcttcacaatgtttaaagtttcaaaatctttttcgctgattttgacgtacttttttggaatcagccaattaatcattgggaaaaagagtgctaaccatgtacttactaaatcaatcatcaaatattcatctttgtatttgataattctatatttgggattcttattaatattttcagtttcacaaagcaatgtctccacttcttttcaattggttttatat |
404. | fkykknrkipsimmqqikitilysyltinkweyllnitpnktvlpatgqkelilavftmfkvsksfsliltyffgisqliigkksanhvltksiikysslyliilylgfllifsvsqsnvstsfqlvly |
405. | ggaatgaaaatgatttcgatttccgatgaaatcaattgtttaatttgttgcaattgtgtagggttatgttcttttatttcttctgctaagtatattttttggatttccatttcttctaacactgtagctaagacatcaataaagcgtggtaagtttttagttacagctaggtcgatacgacga |
406. | gmkmisisdeincliccncvglcsfissakyifwisissntvaktsikrgkflvtarsirr |
407. | tttgaagctacaaaggtaccgcataatggcagcacattaattaacaatgcgctaaactttaatgaggcgctgatttgcttgtctttaaaagtcaacatagcactgataattcctaaaatagctactatacgtggaattgtcatgctcggatactgcggtatatgtaagaaagcaccaagacctgctatcacaccacatactaacgcaatatatagaaattgcttcaaatcattcactcctaaattgttattacactattacaca |
408. | featkvphngstlinnalnfnealiclslkvnialiipkiatirgivmlgycgickkaprpaitphtnaiyrncfksftpklllhyyt |
409. | atgcttgctgctcgcatactattagaatctggtgcagaaggtacgcgtgtagaagataccatgacacgtattgcaaaaaaacttggttacagtgaaagtaacagctttgttacaaacactgtcatccagtttacgttacattcggaatcgtttcctagaatatttagaattacctctcgagatacaaacttaataaaaatttctcaagctaataaaatttcgcgtcaaattacaaacaatgaaatttctttagccgaagcaaaaacgcaacttgaaaaaatatatgttgctaagcgtgacagcagtcttccctttaaaggttttgctgcagcaatgattgcaatgagtttcttatatttacaaggtggtagattgattgatgttttaactgcgatattagcaggtagtctaggatacctagtcactgagattttagatcgtaagttacacgcacagtttatcccagaattcattggttcattagttattgggattatcgccgttattggacatacacttattccaacaggtgacttggcaactattatcattgcggcagtcatgcctattgttcctggtgtattaataacaaacgcaatacaagatttatttggtggacacatgttgatgttcacaacgaaatcattagaagcattggttactgcgtttggcatcggtgctggcgttggtagcgtattaattttagta |
410. | mlaarillesgaegtrvedtmtriakklgysesnsfvtntviqftlhsesfprifritsrdtnlikisqankisrqitnneislaeaktqlekiyvakrdsslpfkgfaaamiamsflylqggrlidvltailagslgylvteildrklhaqfipefigslvigiiavightliptgdlatiiiaavmpivpgvlitnaiqdlfgghmlmfttkslealvtafgigagvgsvlilv |
411. | atgacatttaataaagtattattgagctggatagtcatattgattataacaactagcatatatctattttggcagttgggcgatatcaatgatgtatttaaccagtctattttaatcaatgttagattaccgagattattagaagcattgttgacaggtatgatattaactgttgcaggccttatatttcaaacagttttaaataatgcattggcagatagctttacattaggattggcaagcggcgctacatttggttcaggattagcattatttttaggtttaacaacgttatggattcctgtattttcaataacatttagtttgataacattaataactgtattagtcattacgtcggtattgagccaaggctatccagttagaatcttaatattaagtggtttaatgattggtgcgttattcaattcacttctatattttttgattttattaaaacctcgcaaattaaatacaattgccaattatctgtttggtggttttggtgatgcagaatactcaaatgtatctataatagcaatcacatttatcattgcattgtttggtatatttatcattcttaatcaactaaagttattgcaattaggagaactaaaaagtcagtcactaggcttaaatgttcaattgattacatatatcgcgttatgtatagcttctatgataacggcgataaatgtcgcatatgttggcatcattggattcattggtatggtgataccgcaactcattagaaaatggcagtggaaacaatcattaggaagacaattggctttaaatattgtaactggaggacaaataatggttatggcagattttattggtagccatatattgtcaccagtacaaataccggcaagtattatcattgcattaattggtataccagtgttattttacatgctaatatctcagtcgaaacggttacac |
412. | mtfnkvllswiviliittsiylfwqlgdindvfnqsilinvrlprllealltgmiltvaglifqtvlnnaladsftlglasgatfgsglalflglttlwipvfsitfslitlitvlvitsvlsqgypvrililsglmigalfnsllyflillkprklntianylfggfgdaeysnvsiiaitfiialfgifiilnqlkllqlgelksqslglnvqlityialciasmitainvayvgiigfigmvipqlirkwqwkqslgrqlalnivtggqimvmadfigshilspvqipasiiialigipvlfymlisqskrlh |
413. | atgaacaaacagcaaaaagaatttaaatcattttattcaattagaaagtcatcactaggcgttgcatctgtagcaattagtacacttttattattaatgtcaaatggcgaagcacaagcagcagctgaagaaacaggtggtacaaatacagaagcacaaccaaaaactgaagcagttgcaagtccaacaacaacatctgaaaagctccagaaactaaaccagtagctaatgcttgtctcagtatctaataaagaagttgaggcccctacttctgaaacaaaagaagctaaagaagttaaagaagttaaagcccctaaggaaacaaaagaagttaaaccagcagcaaaagccactaacaatacatatcctattttgaatcaggaacttagagaagcgattaaaaaccctgcaataaaagacaaagatcatagcgcaccaaactctcgtccaattgattttgaaatgaaaaagaaagatggaactcaacagttttatcattatgcaagttctgttaaacctgctagagttattttcactgattcaaaaccagaaattgaattaggattacaatcaggtcaattttggagaaaatttgaagtttatgaaggtgacaaaaagttgccaattaaattagtatcatacgatactgttaaagattatgcttacattcgcttctctgtatcaaacggaacaaaagctgttaaaattgttagttcaacacacttcaataacaaagaagaaaaatacgattacacattaatggaattcgcacaaccaatttataacagtgcagataaattcaaaactgaagaagattataaagctgaaaaattattagcgccatataaaaaagcgaaaacactagaaagacaagtttatgaattaaataaaattcaagataaacttcctgaaaaattaaaggctgagtacaagaagaaattagaggatacaaagaaagctttagatgagcaagtgaaatcagctattactgaattccaaaatgtacaaccaacaaatgaaaaaatgactgatttacaagatacaaaatatgttgtttatgaaagtgttgagaataacgaatctatgatggatacttttgttaaacaccctattaaaacaggtatgcttaacggcaaaaaatatatggtcatggaaactactaatgacgattactggaaagatttcatggttgaaggtcaacgtgttagaactataagcaaagatgctaaaaataatactagaacaattattttcccatatgttgaaggtaaaactctatatgatgctatcgttaaagttcacgtaaaaacgattgattatgatggacaataccatgtcagaatcgttgataaagaagcatttacaaaagccaataccgataaatctaacaaaaaagaacaacaagataactcagctaagaaggaagctactccagctacgcctagcaaaccaacaccatcacctgttgaaaaagaatcacaaaaacaagacagccaaaaagatgacaataaacaattaccaagtgttgaaaaagaaaatgacgcatctagtgagtcaggtaaagacaaaacgcctgctacaaaaccaactaaaggtgaagtagaatcaagtagtacaactccaactaaggtagtatctacgactcaaaatgttgcaaaaccaacaactgcttcatcaaaaacaacaaaagatgttgttcaaacttcagcaggttctagcgaagcaaaagatagtgctccattacaaaaagcaaacattaaaaacacaaatgatggacacactcaaagccaaaacaataaaaatacacaagaaaataaagcaaaatcattaccacaaactggtgaagaatcaaataaagatatgacattaccattaatggcattattagctttaagtagcatcgttgcattcgtattacctagaaaacgtaaaaac |
414. | MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAAEETGGTNTEAQPKTEAVASPTTTSEKAPETKPVANAVSVSNKEVEAPTSETKEAKEVKEVKAPKETKEVKPAAKATNNTYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKKDGTQQFYHYASSVKPARVIFTDSKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSSTHFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQDKLPEKLKAEYKKKLEDTKKALDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPYVEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANTDKSNKKEQQDNSAKKEATPATPSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKPTKGEVESSSTTPTKVVSTTQNVAKPTTASSKTTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNKNTQENKAKSLPQTGEESNKDMTLPLMALLALSSIVAFVLPRKRKN |
415. | atgaattatccaaatggtaaaccatatcgtaaaaatagtgctatagacggagggaaaaagaccgctgcctttagtaatattgagtatggtggacgtggtatgtcacttgaaaaagatatcgaacattcaaatacgttttatcttaaaagcgacattgcagttattcacaaaaagcctacgccagtacaaatagttaatgtcaactatcctaagcggagtaaagctgtgattaacgaagcttattttcgtacaccttcaacaactgattacaacggcgtttatcaaggttattatattgattttgaagcaaaggaaactaaaaacaagacgtcctttcctttaaataatattcatgaccatcaagtcgaacatatgaaaaatgcatatcaacaaaaaggtattgtgtttttaatgattcgttttaaaacgctagatgaagtttatcttttaccctattcaaaattcgaagtattttggaagagatataaagataatattaaaragtctataacagttgatgaaatactaaaaaatggttaccatattccttatcagtatcaaccaagattagactatctaaaagcagttgataagttgatattagatgaaagtgaggaccgcgta |
416. | mnypngkpyrknsaidggkktaafsnieyggrgmslekdiehsntfylksdiavihkkptpvqivnvnypkrskavineayfrtpsttdyngvyqgyyidfeaketknktsfplnnihdhqvehmknayqqkgivflmirfktldevyllpyskfevfwkrykdnikxsitvdeirkngyhipyqyqprldylkavdklildesedrv |
417. | ttgatatatctagataatgcggcaacgacgaaagcatttgaagaagtgttagatacttatttaaaagtaaatcaatcaatgtattataatccgaatagtccgcataaagctggtttgcaggcaaatcaattactacaacaagcaaaaacccaaattaatgcaatgattaattcaaaaacaaattatgatgttgtattcactagtggtgcaactgaatccaataatcttgctttaaaaggtattgcctatcgtaaatttgatacagcgaaggaaataattacatccgtgttagagcatccgtccgtattagaggttgtaagatatttggaagcacacgaaggatttaaagttaaatatgttgatgtaaagaaagatggcagtattaacttagaacacttcaaagaattaatgtcagacaaagtcggtttagtaacatgtatgtatgtaaataatgtaactggacaaatacagcctattccacaaatggctaaagttataaaaaattatcctaaggcacattttcatgtagatgcggttcaagcattcggcaaaatttcaatggatctcaataacatagatagtattagtttaagtggacacaagtttaatggtttaaaaggacaaggcgtcttacttgtaaatcacattcaaaatgttgaaccaactgtccatggtggtggtcaagaatatggcgttagaagtggaacagttaatttgccaaatgatattgcaatggttaaagcgatgaagatagctaatgaaaactttgaagcattgaatgcatttgttactgagttaaataatgacgtccgtcaatttttaaataaatatcatggagtttatattaattcttcaacttcaggttcaccattcgttttaaatattagttttcctggcgtaaaaggtgaagtattagttaatgctttttcaaaatatgacattatgatatctacgacaagtgcttgttcatctaaacgtaataaattaaatgaagtattggctgcaatgggattatcagacaaatctattgaaggtagtataagattatcatttggggctactacaactaaagaagatatagcgaggtttaaagaaatatttatcatcatttatgaggaaattaaggagttgctaaaa |
418. | liyldnaattkafeevldtylkvnqsmyynpnsphkaglqanqllqqaktqinaminsktnydvvftsgatesnnlalkgiayrkfdtakeiitsvlehpsvlevvryleahegfkvkyvdvkkdgsinlehfkelmsdkvglvtcmyvnnvtgqiqpipqmakviknypkahfhvdavqafgkismdlnnidsislsghkfnglkgqgvllvnhiqnveptvhgggqeygvrsgtvnlpndiamvkamkianenfealnafvtelnndvrqflnkyhgvyinsstsgspfvlnisfpgvkgevlvnafskydimisttsacsskrnklnevlaamglsdksiegsirlsfgatttkediarfkeifiiiyeeikellk |
419. | atgtcatatcattggtttaagaaaatgttactttcaacaagtattttaattttaagtagtagtagtttagggcttgcaacgcacacagttgaagcaaaggataacttaaatggagaaaaaccaactactaatttgaatcataatataacttcaccatcagtaaatagtgaaatgaataataatgagactgggacacctcacgaatcaaatcaaacgggtaatgaaggaacaggttcgaatagtcgtgatgctaatcctgattcgaataatgtgaagccagactcaaacaaccaaaacccaagtacagattcaaaaccagacccaaataaccaaaacccaagtccgaatcctaaaccagatccagataacccgaaaccaaaaccggatccaaaaccagacccagataaaccaaagccaaatccggatccaaaaccagatccagataacccgaaaccaaatccagatccaaaaccagacccagataaaccaaagccaaatccggatccaaaaccagatccagataaaccaaagccaaatccgaatccaaaaccagaccctaataagccaaatcctaacccgtcaccagatcccgatcaacctggggattccaatcattctggtggctcgaaaaatggggggacatggaacccaaatgcttcagatggatctaatcaaggtcaatggcaaccaaatgggaatcaaggaaactcacaaaatcctactggtaatgattttgtatcccaacgatttttagccttggcaaatggggcttacaagtataatccgtatattttaaatcaaattaataagttgggcaaagattatggagaagttactgatgaagacatttataatattattcgaaaacaaaatttcagcggaaatgcatatttaaatggattacaacagcaatcgaattactttagattccaatatttcaatccattgaaatcagaaaggtactatcgtaatttagatgaacaagtactcgcattaattactggtgaaattggatcaatgccagatttgaaaaagcccgaagataagccggattcaaaacaacgctcatttgaaccgcatgaaaaagacgattttacagtagttaaaaaacaagaagataataagaaaagtgcgtcaactgcatatagtaaaagttggctagcaattgtatgttctatgatggtggtattttcaatcatgctattcttatttgtaaagcgaaataaaaagaaaaataaaaacgaatcacagcgacga |
420. | msyhwfkkmllstsililsssslglathtveakdnlngekpttnlnhnitspsvnsemnnnetgtphesnqtgnegtgsnsrdanpdsnnvkpdsnnqnpstdskpdpnnqnpspnpkpdpdnpkpkpdpkpdpdkpkpnpdpkpdpdnpkpnpdpkpdpdkpkpnpdpkpdpdkpkpnpnpkpdpnkpnpnpspdpdqpgdsnhsggsknggtwnpnasdgsnqgqwqpngnqgnsqnptgndfvsqrflalangaykynpyilnqinklgkdygevtdediyniirkqnfsgnaylnglqqqsnyfrfqyfnplkseryyrnldeqvlalitgeigsmpdlkkpedkpdskqrsfephekddftvvkkqednkksastayskswlaivcsmmvvfsimlflfvkrnkkknknesqrr |
421. | atgagagataagaaaggaccggtaaataaaagagtagattttctatcaaataaattgaataaatattcaataagaaaatttacagttggaacagcatctattttaattggctcactaatgtatttgggaactcaacaagaggcagaagcagctgaaaacaatattgagaatccaactacattaaaagataatgtccaatcaaaagaagtgaagattgaagaagtaacaaacaaagacactgcaccacagggtgtagaagctaaatctgaagtaacttcaaacaaagacacaatcgaacatgaaccatcagtaaaagctgaagatatatcaaaaaaggaggatacaccaaaagaagtagctgatgttgctgaagttcagccgaaatcgtcagtcactcataacgcagagacacctaaggttagaaaagctcgttctgttgatgaaggctcttttgatattacaagagattctaaaaatgtagttgaatctaccccaattacaattcaaggtaaagaacattttgaaggttacggaagtgttgatatacaaaaaaaaccaacagatttaggggtatcagaggtaaccaggtttaatgttggtaatgaaagtaatggtttgataggagctttacaattaaaaaataaaatagattttagtaaggatttcaattttaaagttagagtggcaaataaccatcaatcaaataccacaggtgctgatggttgggggttcttatttagtaaaggaaatgcagaagaatatttaactaatggtggaatccttggggataaaggtctggtaaattcaggcggatttaaaattgatactggatacatttatacaagttccatggacaaaactgaaaagcaagctggacaaggttatagaggatacggagcttttgtgaaaaatgacagttctggtaattcacaaatggttggagaaaatattgataaatcaaaaactaattttttaaactatgcggacaattcaactaatacatcagatggaaagtttcatgggcaacgtttaaatgatgtcatcttaacttatgttgcttcaactggtaaaatgagagcagaatatgctggtaaaacttgggagacttcaataacagatttaggtttatctaaaaatcaggcatataatttcttaattacatctagtcaaagatggggccttaatcaagggataaatgcaaatggctggatgagaactgacttgaaaggttcagagtttacttttacaccagaagcgccaaaaacaataacagaattagaaaaaaaagttgaagagattccattcaagaaagaacgtaaatttaatccggatttagcaccagggacagaaaaagtaacaagagaaggacaaaaaggtgagaagacaataacgacaccaacactaaaaaatccattaactggagtaattattagtaaaggtgaaccaaaagaagagattacaaaagatccgattaatgaattaacagaatacggacctgaaacaatagcgccaggtcatcgagacgaatttgatccgaagttaccaacaggagagaaagaggaagttccaggtaaaccaggaattaagaatccagaaacaggagacgtagttagaccaccggtcgatagcgtaacaaaatatggacctgtaaaaggagactcgattgtagaaaaagaagagattccattcgagaaagaacgtaaatttaatccggatttagcaccagggacagaaaaagtaacaagagaaggacaaaaaggtgagaagacaataacgacaccaacactaaaaaatccattaactggagtaattattagtaaaggtgaaccaaaagaagaaatcacaaaagatccgattaatgaattaacagaatacggaccagaaacgataacaccaggtcatcgagacgaatttgatccgaagttaccaacaggagagaaagaggaagttccaggtaaaccaggaattaagaatccagaaacaggagacgtagttagaccaccggtcgatagcgtaacaaaatatggacctgtaaaaggagactcgattgtagaaaaagaagaaattccattcaagaaagaacgtaaatttaatccggatttagcaccagggacagaaaaagtaacaagagaaggacaaaaaggtgagaagacaataacgacgccaacactaaaaaatccattaactggagaaattattagtaaaggtgaatcgaaagaagaaatcacaaaagatccgattaatgaattaacagaatacggaccagaaacgataacaccaggtcatcgagacgaatttgatccgaagttaccaacaggagagaaagaggaagttccaggtaaaccaggaattaagaatccagaaacaggagacgtagttagaccaccggtcgatagcgtaacaaaatatggkcctgtaaaaggagactcgattgtagaaaaagaagaaattccattcaagaaagaacgtaaatttaatcctgatttagcaccagggacagaaaaagtaacaagagaaggacaaaaaggtgagaagacaataacgacgccaacactaaaaaatccattaactggagaaattattagtaaaggtgaatcgaaagaagaaatcacaaaagatccgattaatgaattaacagaatacggaccagaaacgataacaccaggtcatcgagacgaatttgatccgaagttaccaacaggagagaaagaggaagttccaggtaaaccaggaattaagaatccagaaacaggagatgtagttagaccaccggtcgatagcgtaacaaaatatggacctgtaaaaggagactcgattgtagaaaaagaagaaattccattcgagaaagaacgtaaatttaatcctgatttagcaccagggacagaaaaagtaacaagagaaggacaaaaaggtgagaagacaataacgacgccaacactaaaaaatccattaactggagaaattattagtaaaggtgaatcgaaagaagaaatcacaaaagatccagttaatgaattaacagaattcggtggcgagaaaataccgcaaggtcataaagatatctttgatccaaacttaccaacagatcaaacggaaaaagtaccaggtaaaccaggaatcaagaatccagacacaggaaaagtgatcgaagagccagtggatgatgtgattaaacacggaccaaaaacgggtacaccagaaacaaaaacatgagagataccgtttgaaacaaaacgtgagtttaatccaaaattacaacctggtgaagagcgagtgaaacaagaaggacaaccaggaagtaagacaatcacaacaccaatcacagtgaacccattaacaggtgaaaaagttggcgagggtcaaccaacagaagagatcacaaaacaaccagtagataagattgtagagttcggtggagagaaaccaaaagatccaaaaggacctgaaaacccagagaagccgagcagaccaactcatccaagtggcccagtaaatcctaacaatccaggattatcgaaagacagagcaaaaccaaatggcccagttcattcaatggataaaaatgataaagttaaaaaatctaaaattgctaaagaatcagtagctaatcaagagaaaaaacgagcagaattaccaaaaacaggtttagaaagcacgcaaaaaggtttgatctttagtagtataattggaattgctggattaatgttattggctcgtagaagaaagaat |
422. | mrdkkgpvnkrvdflsnklnkysirkftvgtasiligslmylgtqqeaeaaennienpttlkdnvqskevkieevtnkdtapqgveaksevtsnkdtiehepsvkaediskkedtpkevadvaevqpkssvthnaetpkvrkarsvdegsfditrdsknvvestpitiqgkehfegygsvdiqkkptdlgvsevtrfnvgnesngligalqlknkidfskdfnfkvrvannhqsnttgadgwgflfskgnaeeyltnggilgdkglvnsggfkidtgyiytssmdktekqagqgyrgygafvkndssgnsqmvgenidksktnflnyadnstntsdgkfhgqrlndviltyvastgkmraeyagktwetsitdlglsknqaynflitssqrwglnqginangwmrtdlkgseftftpeapktitelekkveeipfkkerkfnpdlapgtekvtregqkgektittptlknpltgviiskgepkeeitkdpinelteygpetiapghrdefdpklptgekeevpgkpgiknpetgdvvrppvdsvtkygpvkgdsivekeeipfekerkfnpdlapgtekvtregqkgektittptlknpltgviiskgepkeeitkdpinelteygpetitpghrdefdpklptgekeevpgkpgiknpetgdvvrppvdsvtkygpvkgdsivekeeipfkkerkfnpdlapgtekvtregqkgektittptlknpltgeiiskgeskeeitkdpinelteygpetitpghrdefdpklptgekeevpgdpgiknpetgdvvrppvdsvtkygpvkgdsivekeeipfkkerkfnpdlapgtekvtregqkgektittptlknpltgeiiskgeskeeitkdpinelteygpetitpghrdefdpklptgekeevpgkpgiknpetgdvvrppvdsvtkygpvkgdsivekeeipfekerkfnpdlapgtekvtregqkgektittptlknpltgeiiskgeskeeitkdpvneltefggekipqghkdifdpnlptdqtekvpgkpgiknpdtgkvieepvddvikhgpktgtpetktveipfetkrefnpklqpgeervkqegqpgsktittpitvnpltgekvgegqpteeitkqpvdkivefggekpkdpkgpenpekpsrpthpsgpvnpnnpglskdrakpngpvhsmdkndkvkkskiakesvanqekkraelpktglestqkglifssiigiaglmllarrrkn |
423. | gtgaaaagcaatcttagatacggcataagaaaacacaaattgggagcggcctcagtattcttaggaacaatgatcgttgttggaatgggacaagaaaaagaagctgcagcatcggaacaaaacaatactacagtagaggaaagtgggagttcagctactgaaagtaaagcaagcgaaacacaaacaactacaaataacgttaatacaatagatgaaacacaatcatacagcgcgacatcaactgagcaaccatcacaatcaacacaagtaacaacagaagaagcaccgaaaactgtgcaagcaccaaaagtagaaacttcgcgagttgatttgccatcggaaaaagttgctgataaggaaactacaggaactcaagttgacatagctcaaccaagtaacgtctcagaaattaaaccaagaatgaaaagatcaactgacgttacagcagttgcagagaaagaagtagtggaagaaactaaagcgacaggtacagatgtaacaaataaagtggaagtagaagaaggtagtgaaattgtaggacataaacaagatacgaatgttgtaaatcctcataacgcagaaagagtaaccttgaaatataaatggaaatttggagaaggaattaaggcgggagattattttgatttcacattaagcgataatgttgaaactcatggtatctcaacactgcgtaaagttccggagataaaaagtacagatggtcaagttatggcgacaggagaaataattggagaaagaaaagttagatatacgtttaaagaatatgtacaagaaaagaaagatttaactgctgaattatctttaaatctatttattgatcctacaacagtgacgcaaaaaggtaaccaaaatgttgaagttaaattgggtgagactacggttagcaaaatatttaatattcaatatttaggtggagttagagataattggggagtaacagctaatggtcgaattgatactttaaataaagtagatgggaaatttagtcattttgcgtacatgaaacctaacaaccagtcgttaagctctgtgacagtaactggtcaagtaactaaaggaaataaaccaggggttaataatccaacagttaaggtatataaacacattggttcagacgatttagctgaaagcgtatatgcaaagcttgatgatgtcagcaaatttgaagatgtgactgataatatgagtttagattttgatactaatggtggttattctttaaactttaataatttagaccaaagtaaaaattatgtaataaaatatgaagggtattatgattcaaatgctagcaacttagaatttcaaacacacctttttggatattataactattattatacaagtaatttaacttggaaaaatggcgttgcattttactctaataacgctcaaggcgacggcaaagataaactaaaggaacctattatagaacatagtactcctatcgaacttgaatttaaatcagagccgccagtggagaagcatgaattgactggtacaatcgaagaaagtaatgattctaagccaattgattttgaatatcatacagctgttgaaggtgcagaaggtcatgcagaaggtaccattgaaactgaagaagattctattcatgtagactttgaagaatcgacacatgaaaattcaaaacatcatgctgatgttgttgaatatgaagaagatacaaacccaggtggtggtcaggttactactgagtctaacctagttgaatttgacgaagattctacaaaaggtattgtaactggtgctgttagcgatcatacaacaattgaagatacgaaagaatatacgactgaaagtaatctgattgaactagtagatgaactacctgaagaacatggtcaagcgcaaggaccaatcgaggaaattactgaaaacaatcatcatatttctcattctggtttaggaactgaaaatggtcacggtaattatggcgtgattgaagaaatcgaagaaaatagccacgtggatattaagagtgaattaggttacgaaggtggccaaaatagcggtaatcagtcatttgaggaagacacagaagaagataaaccgaaatatgaacaaggtggcaatatcgtagatatcgatttcgatagtgtacctcaaattcatggtcaaaataatggtaaccaatcattcgaagaagatacagagaaagacaaacctaagtatgaacaaggtggtaatatcattgatatcgacttcgacagtgtgccacatattcacggattcaataagcacactgaaattattgaagaagatacaaataaagataaaccaaattatcaattcggtggacacaatagtgttgactttgaagaagatacacttccacaagtaagtggtcataatgaaggtcaacaaacgattgaagaagatacaacacctccaatcgtgccaccaacgccaccgacaccagaagtaccaagcgagccggaaacaccaacaccaccgacaccagaagtaccaagcgagccggaaacaccaacaccgccaacgccagaggtaccaactgaacctggtaaaccaataccacctgctaaagaagaacctaaaaaaccttctaaaccagtggaacaaggtaaagtagtaacacctgttattgaaatcaatgaaaaggttaaagcagtggtaccaactaaaaaagcacaatctaagaaatctgaactacctgaaacaggtggagaagaatcaacaaacaacggcatgttgttcggcggattatttagcattttaggtttagcgttattacgcagaaataaaaagaatcacaaagca |
424. | vksnlrygirkhklgaasvflgtmivvgmgqekeaaaseqnnttveesgssateskasetqtttnnvntidetqsysatsteqpsqstqvtteeapktvqapkvetsrvdlpsekvadkettgtqvdiaqpsnvseikprmkrstdvtavaekevveetkatgtdvtnkveveegseivghkqdtnvvnphnaervtlkykwkfgegikagdyfdftlsdnvethgistlrkvpeikstdgqvmatgeiigerkvrytfkeyvqekkdltaelslnlfidpttvtqkgnqnvevklgettvskifniqylggvrdnwgvtangridtlnkvdgkfshfaymkpnnqslssvtvtgqvtkgnkpgvnnptvkvykhigsddlaesvyaklddvskfedvtdnmsldfdtnggyslnfnnldqsknyvikyegyydsnasnlefqthlfgyynyyytsnltwkngvafysnnaqgdgkdklkepiiehstpielefkseppvekheltgtieesndskpidfeyhtavegaeghaegtieteedsihvdfeesthenskhhadvveyeedtnpgggqvttesnlvefdedstkgivtgavsdhttiedtkeyttesnlielvdelpeehgqaqgpieeitennhhishsglgtenghgnygvieeieenshvdikselgyeggqnsgnqsfeedteedkpkyeqggnivdidfdsvpqihgqnngnqsfeedtekdkpkyeqggniididfdsvphihgfnkhteiieedtnkdkpnyqfgghnsvdfeedtlpqvsghnegqqtieedttppivpptpptpevpsepetptpptpevpsepetptpptpevptepgkpippakeepkkpskpveqgkvvtpvieinekvkavvptkkaqskkselpetggeestnngmlfgglfsilglallrrnkknhka |
425. | atgaaagctttattacttaaaacaagtgtatggctcgttttgctttttagtgtaatgggattatggcaagtctcgaacgcggctgagcagcatacaccaatgaaagcacatgcagtaacaacgatagacaaagcaacaacagataagcaacaagtaccgccaacaaaggaagcggctcatcattctggcaaagaagcggcaaccaacgtatcagcatcagcgcagggaacagctgatgatacaaacagcaaagtaacatccaacgcaccatctaacaaaccatctacagtagtttcaacaaaagtaaacgaaacacgcgacgtagatacacaacaagcctcaacacaaaaaccaactcacacagcaacgttcaaattatcaaatgctaaaacagcatcactttcaccacgaatgtttgctgctaatgcaccacaaacaacaacacataaaatattacatacaaatgatatccatggccgactagccgaagaaaaagggcgtgtcatcggtatggctaaattaaaaacagtaaaagaacaagaaaagcctgatttaatgttagacgcaggagacgccttccaaggtttaccactttcaaaccagtctaaaggtgaagaaatggctaaagcaatgaatgcagtaggttatgatgctatggcagtcggtaaccatgaatttgactttggatacgatcagttgaaaaagttagagggtatgttagacttcccgatgctaagtactaacgtttataaagatggaaaacgcgcgtttaagccttcaacgattgtaacaaaaaatggtattcgttatggaattattggtgtaacgacaccagaaacaaagacgaaaacaagacctgaaggcattaaaggcgttgaatttagagatccattacaaagtgtgacagcggaaatgatgcgtatttataaagacgtagatacatttgttgttatatcacatttaggaattgatccttcaacacaagaaacatggcgtggtgattacttagtgaaacaattaagtcaaaatccacaattgaagaaacgtattacagttattgatggtcattcacatacagtacttcaaaatggtcaaatttataacaatgatgcattggcacaaacaggtacagcacttgcgaatatcggtaagattacatttaattatcgcaatggagaggtatcgaatattaaaccgtcattgattaatgttaaagacgttgaaaatgtaacaccgaacaaagcattagctgaacaaattaatcaagctgatcaaacatttagagcacaaactgcagaggtaattattccaaacaataccattgatttcaaaggagaaagagatgacgttagaacgcgtgaaacaaatttaggaaacgcgattgcagatgctatggaagcgtatggcgttaagaatttctctaaaaagactgactttgccgtgacaaatggtggaggtattcgtgcctctatcgcaaaaggtaaggtgacacgctatgatttaatctcagtattaccatttggaaatacgattgcgcaaattgatgtaaaaggttcagacgtctggacggctttcgaacatagtttaggcgcaccaacaacacaaaaggacggtaagacagtgttaacagcgaatggcggtttactacatatctctgattcaatccgtgtttactatgatataaataaaccgtctggcaaacgaattaatgctattcaaattttaaataaagagacaggtaagtttgaaaatattgatttaaaacgtgtatatcacgtaacgatgaatgacttcacagcatcaggtggcgacggatatagtatgttcggtggtcctagagaagaaggtatttcattagatcaagtactagcaagttatttaaaaacagctaacttagctaagtatgatacgacagaaccacaacgtatgttattaggtaaaccagcagtaagtgaacaaccagctaaaggacaacaaggtagcaaaggtagtaagtctggtaaagatacacaaccaattggtgacgacaaagtgatggatccagcgaaaaaaccagctccaggtaaagttgtattgttgctagcgcatagaggaactgttagtagcggtacagaaggttctggtcgcacaatagaaggagctactgtatcaagcaagagtgggaaacaattggctagaatgtcagtgcctaaaggtagcgcgcatgagaaacagttaccaaaaactggaactaatcaaagttcaagcccagaagcgatgtttgtattattagcaggtataggtttaatcgcgactgtacgacgtagaaaagctaggc |
426. | mkalllktsvwlvllfsvmglwqvsnaaeqhtpmkahavttidkattdkqqvpptkeaahhsgkeaatnvsasaqgtaddtnskvtsnapsnkpstvvstkvnetrdvdtqqastqkpthtatfklsnaktaslsprmfaanapqttthkilhtndihgrlaeekgrvigmaklktvkeqekpdlmldagdafqglplsnqskgeemakamnavgydamavgnhefdfgydqlkklegmldfpmlstnvykdgkrafkpstivtkngirygiigvttpetktktrpegikgvefrdplqsvtaemmriykdvdtfvvishlgidpstqetwrgdylvkqlsqnpqlkkritvidghshtvlqngqiynndalaqtgtalanigkitfnyrngevsnikpslinvkdvenvtpnkalaeqinqadqtfraqtaeviipnntidfkgerddvrtretnlgnaiadameaygvknfskktdfavtngggirasiakgkvtrydlisvlpfgntiaqidvkgsdvwtafehslgapttqkdgktvltanggllhisdsirvyydinkpsgkrinaiqilnketgkfenidlkrvyhvtmndftasggdgysmfggpreegisldqvlasylktanlakydttepqrmllgkpavseqpakgqqgskgsksgkdtqpigddkvmdpakkpapgkvvlllahrgtvssgtegsgrtiegatvssksgkqlarmsvpkgsahekqlpktgtnqssspeamfvllagigliatvrrrkas |
427. | atgaataaaaattcgaagaagaagctcgattttcttccaaacaagcttaataagtactcaattagacgtttcactgtagggacagcttcgattttagtaggagctactttaattttcggtgttgcaaatgatcaagcagaagccgctgagaataacacaactcaaaagcaagatgatagttcagatgcaagtaaagtaaaaggtaatgttcaaactattgaacaatcttctgcaaattcaaatgaatctgatattcctgaacaagttgatgtaactaaagatacaactgaacaagcatcaacagaagaaaaagcaaatacaactgaacaagcatcaacagaagaaaaagcagatacaactgaacaagcaacaacagaagaagcgccaaaagctgaaggaacagacaaagtagaaacagaagaagcgccaaaagctgaagaaacagacaaagcaacaacagaagaagcgccaaaagctgaagaaacagacaaagcaacagaagaagcaccaaaaactgaagaaacagacaaagcaacaacagaagaagcgccagcagctgaagaaacaagcaaagcagcaacagaagaagcgccaaaagctgaagaaacaagcaaagcagcaacagaagaagcgccaaaagctgaagaaacagaaaaaacagcaacagaagaagcaccaaaaactgaagaaacagacaaagtagaaacagaagaagcgccaaaagctgaagaaacaagcaaagcagcaacagaaaaagcaccaaaagctgaagaaacaaacaaagtagaaacagaagaagcgccagcagctgaagaaacaaacaaagcagcaacagaagaaacaccagcagttgaagacacaaatgctaagagcaattcaaatgctcaaccatcagaaactgagagaactcaagttgtagatacagttgctaaagatttatataaaaaatctgaagttacagaagcagaaaaagctgaaattgaaaaagtattaccaaaagatatttcaaacttatctaatgaagaaattaaaaaaatagctttaagtgaagtacttaaagaaacagctaacaaagaaaacgcacaaccaagagcaacattccgttcagtaagcagcaatgctagaacaacaaatgttaactattcagcaacagcattaagagcagctgcacaagacacagttactaaaaaaggaactggtaactttactgcgcatggagatataatccataaaacttataaagaagaattccctaatgaaggcacgctaactgcattcaatacaaacttcaatcctaatacaggaactaaaggcgcattagaatataatgataaaatagattttaataaagactttacaattactgttccagtagcaaacaacaaccaaggtaatacaacaggagcagatggctggggcttcatgtttactcaagggaatggccaagacttcttaaaccaaggtggtattttaagagacaaaggtatggcaaatgcatctggttttaaaattgatacggcatataataatgttaatggtaaagtcgataaactcgatgcagataaaacaaacaatctaagtcaaattggcgcagcaaaagttggttacggtacatttgttaaaaatggtgcagatggtgtgactaaccaagttggtcaaaatgccctaaatacaaaagataaacctgtaaataaaataatttatgcagataatacaactaatcatcttgatggtcaattccatggccaaagattaaatgatgtagtattaaattatgatgcagcaacaagtacaataactgctacatatgcaggaaaaacatggaaagctactacagatgatttaggaattgataaatcacaaaaatataatttcttaattacttcaagtcatatgcaaaatagatattctaatggaattatgagaacaaatcttgaaggtgtaacaattacaacgcctcaagctgatttaattgatgatgtggaagtaacgaaacaaccaattcctcataaaactattcgtgagtttgatccaactctagaaccaggctcacctgatgttattgtacaaaaaggtgaagatggagagaaaacaacaactacaccaactaaagttgaccctgatacaggagatgtagttgaacgtggtgaaccaacaacagaagttacaaaaaatccagttgacgagattgtacactttacacctgaagaagtaccacaaggtcataaagatgagttcgatccaaacttaccaattgacggtacagaagaagtaccaggtaaaccaggcatcaagaatcctgaaacaggtgaagtagtaacacctccggtttacgatgtcacaaaacatggtccaaaagcaggcgaaccagaggttactaaagaagaaataccattcgagaaaaaacgtgagttcaatccagacttaaaaccaggtgaagagaaagtaacgcaagaaggacaaactggagagaaaacaacaacaacgccaacaacaattaatccattaacgggagaaaaagtaggcgaaggtgaaccaacaacagaagtaacaaaagaaccagtagatgaaatcacacaattcggtggagaagaagtaccacaaggtcataaagatgagttcgatccaaacttaccaattgacggtacagaagaagtaccaggtaaaccaggcatcaagaatcctgaaacaggtgaagtagtaacacctccggttgacgatgtcacaaaacatggtccaaaagcaggcgaaccagaggttactaaagaagaaataccattcgagaaaaaacgtgagttcaatccagacttaaaaccaggtgaagagaaagtaacgcaagaaggacaaactggagagaaaacaacaacaacgccaacaacaattaatccattaacgggagaaaaagtaggcgaaggtgaaccaacaacagaagtaacaaaagaaccagtagatgaaatcacacaattcggtggagaagaagtaccacaaggtcataaagatgagttcgatccaaacttaccaattgacggtacagaagaagtaccaggtaaaccaggcatcaagaatcctgaaacaggtgaagtagtaacacctccggttgacgatgtcacaaaacatggtccaaaagcaggcgaaccagaggttactaaagaagaaataccattcgagaaaaaacgtgagttcaatccagacttaaaaccaggtgaagagaaagtaacgcaagaaggacaaactggagagaaaacaacaacaacgccaacaacaattaatccattaacgggagaaaaagtaggcgaaggtgaaccaacaacagaagtaacaaaagaaccagtagatgaaatcacacaattcggtggagaagaagtaccacaaggtcataaagatgagttcgatccaaacttaccaattgacggtacagaagaagtaccaggtaaaccaggcatcaagaatcctgaaacaggtgaagtagtaacaccaccagtagacgatgtcacaaaacatggtccaaaagcaggcgaaccagaggttactaaagaagaaattccatatgaaactaaacgcgtattagatccaacaatggaaccaggtagtcctgataaagtagctcaaaaaggtgaaaatggtgaaaaaacaacaacaacaccaactacaattaatccattaacgggagaaaaagtaggcgaaggcgaaccaacaacggaagtaacgaaagaaccaatagacgaaattgttaactatgcacctgaaattattcctcatggtacacgtgaagaaattgatccaaacttaccagaaggtgaaactaaagttatcccaggtaaagatggcttgaaagatcctgaaactggagaaatcattgaagaaccacaagatgaagtaatcatccatggtgctaaagatgattcagatgcggacagcgattcagacgcagatagcgattctgatgcagacagcgactcagacgcagatagcgactctgatgcggacagcgattcagacagcgatagcgattcagattcagatagcgactctgatgcggacagcgattcagacagcgatagcgattcagacgcagatagcgattctgatgcagacagcgactcagacgcagatagcgactcagattcagacgcagatagcgactcagattcagacgcagatagcgactcagattcagacagcgactcagacgcagacagcgactcagattcagacagcgattcagacgcagacagcgactcagacgcagatagcgactcagattcagacagcgattcagacgcagatagcgattcagattcagatagtgactctgatgcggacagcgactcagacgcagatagcgactctgatgcggacagcgactcagacgcagatagcgattctgattcagacagcgattcagacgcagatagcgactcagacgcagatagcgattcagacgcagatagcgactcagacgcagatagcgattcagattcagatagcgactctgatgcggacagcgatagcgattcagattcagacagcgactcagacgcagatagcgactcagacgcagatagcgatagcgattctgatgcagacagcgactcagacgcagatagcgactctgatgcggacggcgactcagacgcagatagcgattctgatgcagacagcgactcagacagcgatagcgattctgattcagacagcgattcagacgcagatagcgactcagattcagacagcgattcagacgcagatagagatcataatgacaaaacagataaaccaaataataaagagttaccagatactggtaatgatgctcaaaataatggcacattatttggttcactattcgctgcgcttggaggattattcttagttggcagacgtcgtaaaaacaaaaataatgaagaaaaa |
428. | mnknskkkldflpnklnkysirrftvgtasilvgatlifgvandqaeaaennttqkqddssdaskvkgnvqtieqssansnesdipeqvdvtkdtteqasteekantteqasteekadtteqatteeapkaegtdkveteeapkaeetdkatteeapkaeetdkateeapkteetdkatteeapaaeetskaateeapkaeetskaateeapkaeetektateeapkteetdkveteeapkaeetskaatekapkaeetnkveteeapaaeetnkaateetpavedtnaksnsnaqpsetertqvvdtvakdlykksevteaekaeiekvlpkdisnlsneeikkialsevlketankenaqpratfrsvssnarttnvnysatalraaaqdtvtkkgtgnftahgdiihktykeefpnegtltafntnfnpntgtkgaleyndkidfnkdftitvpvannnqgnttgadgwgfmftqgngqdflnqggilrdkgmanasgfkidtaynnvngkvdkldadktnnlsqigaakvgygtfvkngadgvtnqvgqnalntkdkpvnkiiyadnttnhldgqfhgqrlndvvlnydaatstitatyagktwkattddlgidksqkynflitsshmqnrysngimrtnlegvtittpqadliddvevtkqpipnktirefdptlepgspdvivqkgedgekttttptkvdpdtgdvvergepttevtknpvdeivhftpeevpqghkdefdpnlpidgteevpgkpgiknpetgevvtppvddvtkhgpkagepevtkeeipfekkrefnpdlkpgeekvtqegqtgekttttpttinpltgekvgegepttevtkepvdeitqfggeevpqghkdefdpnlpidgteevpgkpgiknpetgevvtppvddvtkhgpkagepevtkeeipfekkrefnpdlkpgeekvtqegqtgekttttpttinpltgekvgegepttevtkepvdeitqfggeevpqghkdefdpnlpidgteevpgkpgiknpetgevvtppvddvtkhgpkagepevtkeeipfekkrefnpdlkpgeekvtgegqtgekttttpttinpltgekvgegepttevtkepvdeitqfggeevpqghkdefdpnlpidgteevpgkpgiknpetgevvtppvddvtkhgpkagepevtkeeipyetkrvldptmepgspdkvaqkgengekttttpttinpltgekvgegepttevtkepideivnyapeiiphgtreeidpnlpegetkvipgkdglkdpetgeiieepqdeviihgakddsdadsdsdadsdsdadsdsdadsdsdadsdsdsdsdsdsdsdsdadsdsdsdsdsdadsdsdadsdsdadsdsdsdadsdsdsdadsdsdsdsdsdadsdsdsdsdsdadsdsdadsdsdsdsdsdadsdsdsdsdsdadsdsdadsdsdadsdsdadsdsdsdsdsdadsdsdadsdsdadsdsdadsdsdsdsdsdadsdsdsdsdsdsdadsdadadsdsdsdadsdsdadsdsdadgdsdadsdsdadsdsdsdsdsdsdsdsdadsdsdsdsdsdadrdhndktdkpnnkelpdtgndaqnngtlfgslfaalgglflvgrrrknknneek |
429. | ttgaaaaagaaaaacatttattcaattcgtaaactaggtgtaggtattgcatctgtaactttaggtacattacttatatctggtggcgtaacacctgctgcaaatgctgcgcaacacgatgaagctcaacaaaatgctttttatcaagtcttaaatatgcctaacttaaatgctgatcaacgcaatggttttatccaaagccttaaagatgatccaagccaaagtgctaacgttttaggtgaagctcaaaaacttaatgactctcaagctccaaaagctgatgcgcaacaaaataacttcaacaaagatcaacaaagcgccttctatgaaatcttgaacatgcctaacttaaacgaagcgcaacgtaacggcttcattcaaagtcttaaagacgacccaagccaaagcactaacgttttaggtgaagctaaaaaattaaacgaatctcaagcaccgaaagctgataacaatttcaacaaagaacaacaaaatgctttctatgaaatcttgaatatgcctaacttaaacgaagaacaacgcaatggtttcatccaaagcttaaaagatgacccaagccaaagtgctaacctattgtcagaagctaaaaagttaaatgaatctcaagcaccgaaagcggataacaaattcaacaaagaacaacaaaatgctttctatgaaatcttacatttacctaacttaaacgaagaacaacgcaatggtttcatccaaagcctaaaagatgacccaagccaaagcgctaaccttttagcagaagctaaaaagctaaatgatgctcaagcaccaaaagctgacaacaaattcaacaaagaacaacaaaatgctttctatgaaattttacatttacctaacttaactgaagaacaacgtaacggcttcatccaaagccttaaagacgatccttcagtgagcaaagaaattttagcagaagctaaaaagctaaacgatgctcaagcaccaaaagaggaagacaataacaagcctggcaaagaagacaataacaagcctggcaaagaagacaacaacaagcctggtaaagaagacaacaacaagcctggcaaagaagacggcaacaagcctggtaaagaagacaacaaaaaacctggtaaagaagatggcaacaagcctggtaacgaagacaacaaaaaacctggtaaagaagacggcaacaagcctggcaaagaagatggcaacaaacctggtaaagaagatggtaacggagtacatgtcgttaaacctggtgatacagtaaatgacattgcaaaagcaaacggcactactgctgacaaaattgctgcagataacaaattagctgataaaaacatgatcaaacctggtcaagaacttgttgttgataagaagcaaccagcaaaccatgcagatgctaacaaagctcaagcattaccagaaactggtgaagaaaatccattcatcggtacaactgtatttggtggattatcattagccttaggtgcagcgttattagctggacgtcgtcgcgaacta |
430. | lkkkniysirklgvgiasvtlgtllisggvtpaanaaqhdeaqqnafyqvlnmpnlnadqrngfiqslkddpsqsanvlgeaqklndsqapkadaqqnnfnkdqqsafyeilnmpnlneaqrngfiqslkddpsqstnvlgeakklnesqapkadnnfnkeqqnafyeilnmpnlneeqrngfiqslkddpsqsanllseakklnesqapkadnkfnkeqqnafyeilhlpnlneeqrngfiqslkddpsqsanllaeakklndaqapkadnkfnkeqqnafyeilhlpnlteeqrngfiqslkddpsvskeilaeakklndaqapkeednnkpgkednnkpgkednnkpgkednnkpgkedgnkpgkednkkpgkedgnkpgkednkkpgkedgnkpgkedgnkpgkedgngvhvvkpgdtvndiakangttadkiaadnkladknmikpgqelvvdkkqpanhadankaqalpetgeenpfigttvfgglslalgaallagrrrel |
431. | atgaagaaaacaattttactgacgatgacaactcttactttatttagtatgtcgcctaactcggctcaagcatatacgaatgatagcaaaacattagaagaagcaaagaaagcacacccaaacgcacagttcaaagtgaataaagacaccggcgcgtatacttatacatatgacaaaaacaacacgccaaacaacaatcatcaaaaccagtcacgtacaaacgacaatcatcaacacgcaaatcaacgtgatcttaacaacaatcagtaccattcttcattaagtggtcagtatacgcacattaatgacgcaattgattcacacacaccgcctcaaacgtcaccaagcaatcctttgacaccagcaataccgaatgtcgaagacaatgacgatgaattaaataacgctttttcaaaagataacaaagggcttattacaggcatcgatttagacgaattgtatgacgaattacaaatcgccgaatttaatgacaaagcaaagaccgctgacggtaaacctttagcattaggtaacggtaaaatcattgatcagcctcttatcacaagtaagaacaacttatatactgctggacaatgtacatggtatgtctttgataaacgtgccaaagatggacacacgattagtacattttggggagatgctaaaaactgggcaggccaagcttcaagcaatggcttcaaagtagatagacacccaacacgaggatcaattttacaaacagtaaatggtccatttggtcatgtagcctacgttgaaaaagttaatattgatggaagtattctaatttcagaaatgaactggattggtgaatatatcgtttcatcaagaaccatctctgcttcagaagtttcatcatataattacatccat |
432. | mkktilltmttltlfsmspnsaqaytndsktleeakkahpnaqfkvnkdtgaytytydknntpnnnbqnqsrtndnhqhanqrdlnnnqyhsslsgqythindaidshtppqtspsnpltpaipnvednddelnnafskdnkglitgidldelydelqiaefndkaktadgkplalgngkiidqplitsknnlytagqctwyvfdkrakdghtistfwgdaknwagqassngfkvdrhptrgsilqtvngpfghvayvekvnidgsilisemnwigeyivssrtisasevssynyih |
433. | atgaatcaatatcattctaatgcacaacaaccaagtgcatggcgtttttttgtctatagtttagtgggcatactatgtttctttattccttttacgattaatggtaacaacactattttcgtcgatcatgttcatctagccattcgctcaatcataggtccacttatgccctatgttgcactgattatgattttaattggtacagcgttaccaatagtgagacgtacttttatgacttcaatcacaaacttggtcattacattatttaaagttgcaggtgcaatgatcggtataatgtatgtatttaaaatcggtccatcaatactatttaaagctaactatggtccgtttttgtttgaaaaattaatgatgccattaagtatcttaattccagtaggtgcaattgcgctttctttattagtgggctatggcttattagaatttgtcggtgtttatatggagcctattatgagacctatttttaaaacaccaggaaaatccgctgtcgatgcagtggcttcgtttgtcggcagttattccttaggattattgattactaatcgtgtctataagcaagggatgtacaacaaacgagaagccacgattattgcgactggcttttcaacagtttcagcaacttttatgattatcgttgctaaaactttaggattaatgccgcattggaatttatacttttggataactttagtcatcacatttgtcgtgactgcaattactgcatggctaccgccaatcagcaatgaatcaacagaatattataacggacaagaaggagaacaagaagttgctattgaaggaagcagactgaaaactgcatatgcagaggcgatgaaacaaaatgcattaacaccatctctcgtgaagaacgtttgggacaatttgaaagacggtttagaaatgactgttggtattttaccttctatattatcgattggttttttaggactgattgtagcgaactatacaccattcattgattggcttggctatatcttctatccatttatttatattttcccaattgctgatcaggctttactagcaaaagcgtcagcgatttctattgtagagatgtttctaccatctttgttagtaactaaagctgcaatgagtactaaatttgtcgtcggtgtagtaagcgtatcagccattatctttttctcagcattagtgccatgtatactagcaactgaaattaaaatacctgtctggaaactcatcatcatttggtttttacgcgtggcgttgtcgctattaatcaccatccccgtcgctttacttatttttgga |
434. | mnqyhsnaqqpsawrffvyslvgilcffipftingnntifvdhvhlairsiigplmpyvalimiligtalpivrrtfmtsitnlvitlfkvagamigimyvfkigpsilfkanygpflfeklmmplsilipvgaialsllvgygllefvgvymepimrpifktpgksavdavasfvgsyslgllitnrvykqgmynkreatiiatgfstvsatfmiivaktlglmphwnlyfwitlvitfvvtaitawlppisnesteyyngqegeqevaiegsrlktayaeamkqnaltpslvknvwdnlkdglemtvgilpsilsigflglivanytpfidwlgyifypfiyifpiadqallakasaisivemflpsllvtkaamstkfvvgvvsvsaiiffsalvpcilateikipvwkliiiwflrvalsllitipvallifg |
435. | atgaaaatgagaacaattgctaaaaccagtttagcactagggcttttaacaacaggcgcaattacagtaacgacgcaatcggtcaaagcagaaaaaatacaatcaactaaagttgacaaagtaccaacgcttaaagcagagcgattagcaatgataaacataacagcaggtgcaaattcagcgacaacacaagcagctaacacaagacaagaacgcacgcctaaactcgaaaaggcaccaaatactaatgaggaaaaaacctcagcttccaaaatagaaaaaatatcacaacctaaacaagaagagcagaaaacgcttaatatatcagcaacgccagcgcctaaacaagaacaatcacaaacgacaaccgaatccacaacgccgaaaactaaagtgacaacacctccatcaacaaacacgccacaaccaatgcaatctactaaatcagacacaccacaatctccaaccataaaacaagcacaaacagatatgactcctaaatatgaagatttaagagcgtattatacaaaaccgagttttgaatttgaaaagcagtttggatttatgctcaaaccatggacgacggttaggtttatgaatgttattccaaataggttcatctataaaatagctttagttggaaaagatgagaaaaaatataaagatggaccttacgataatatcgatgtatttatcgttttagaagacaataaatatcaattgaaaaaatattctgtcggtggcatcacgaagactaatagtaaaaaagttaatcacaaagtagaattaagcattactaaaaaagataatcaaggtatgatttcacgcgatgtttcagaatacatgattactaaggaagagatttccttgaaagagcttgattttaaattgagaaaacaacttattgaaaaacataatctttacggtaacatgggttcaggaacaatcgttattaaaatgaaaaacggtgggaaatatacgtttgaattacacaaaaaactgcaagagcatcgtatggcaggcactaatattgataacattgaagtgaatataaaa |
436. | mkmrtiaktslalgllttgaitvttqsvkaekiqstkvdkvptlkaerlaminitagansattqaantrqertpklekapntneektsaskiekisqpkqeeqktlnisatpapkqeqsqtttesttpktkvttppstntpqpmqstksdtpqsptikqaqtdmtpkyedlrayytkpsfefekqfgfmlkpwttvrfmnvipnrfiykialvgkdekkykdgpydnidvfivlednkydlkkysvggitktnskkvnhkvelsitkkdnqgmisrdvseymitkeeislkeldfklrkqliekhnlygnmgsgtivlkmknggkytfelhkklqehrmagtnidnievnik |
437. | atgaaaataacaacgattgctaaaacaagtttagcactaggccttttaacaacaggtgtaatcacaacgacaacgcaagcagcaaacgcgacaacaccatcttccactaaagtggaagcaccacaatcaacaccgccctcaactaaaatagaagcaccgcaatcaaaaccaaacgcgacaacaccgccctcaactaaagtagaagcaccgcaacaaacagcaaatgcgacaacaccgccttcaactaaagtgacaacacctccatcaacaaacacgccacaaccaatgcaatctactaaatcagacacaccacaatcgccaaccacaaaacaagtaccaacagaaataaatcctaaatttaaagatttaagagcgtattatacgaaaccaagtttagaatttaaaaatgagattggtattattttaaaaaaatggacgacaataagatttatgaatgttgtcccagattatttcatatataaaattgctttagttggtaaagatgataaaaaatatggtgaaggagtacataggaatgtcgatgtatttgtcgttttagaagaaaataattacaatctggaaaaatattctgtcggtggtatcacaaagagtaatagtaaaaaagttgatcacaaagcaggagtaagaattactaaggaagataataaaggtacaatctctcatgatgtttcagaattcaagattactaaagaacagatttccttgaaagaacttgattttaaattgagaaaacaacttattgaaaaaaataatctgtacggtaacgttggttcaggtaaaattgttattaaaatgaaaaacggtggaaagtacacgtttgaattgcacaaaaaattacaagaaaatcgcatggcagatgtcattaatagtgaacaaattaaaaacatcgaagtgaatttgaaa |
438. | mkittiaktslalgllttgvittttqaanattpsstkveapqstppstkieapqskpnattppstkveapqqtanattppstkvttppstntpqpmqstksdtpqspttkqvpteinpkfkdlrayytkpslefkneiglilkkwttirfmnvvpdyfiykialvgkddkkygegvhrnvdvfvvleennynlekysvggitksnskkvdhkagvritkednkgtishdvsefkitkeqislkeldfklrkqlieknnlygnvgsgkivikmknggkytfelhkklqenrmadvinseqiknievnlk |
439. | gtgaattatcgtgataaaattcaaaagtttagtattcgtaaatatacagttggtacattttcaactgtcattgcgacattggtatttttaggattcaatacatcacaagcacatgctgctgaaacaaatcaaccagcaagcgtggttaaacagaaacaacaaagtaataatgaacagactgagaatcgagaatctcaagtacaaaattctcaaaattcacaaaatggtcaatcattatctgctactcatgaaaatgagcaaccaaatattagtcaagctaatttagtagatcaaaaagtagcgcaatcatctactactaatgatgaacaaccagcatctcaaaatgtaaatacaaagaaagattcggcaacggctgcgacaacacaaccagataaagaacaaagtaagcataaacaaaacgaaagtcaatctgctaataaaaatggaaacgacaatagagcggctcatgtagaaaatcatgaagcaaatgtagtaacagcttcagattcatctgataatggtaacgtacaacatgaccgaaatgaattacaagcgttttttgatgcaaattatcatgattatcgctttattgaccgtgaaaatgcagattctggcacatttaactatgtaaaaggcatttttgataagattaatacgttattaggcagtaatgatccaataaacaataaagacttgcaacttgcatacaaagaattggaacaagctgttgctttaattcgtacaatgcctcaacgtcaacagactagccgacgttcaaatagaattcaaacgcgttcggttgagtcaagagctgcagagcctagatcagtatcagactatcaaaatgcaaattcatcatattatgttgaaaatgctaatgatggttcgggctatcctgttggtacatatatcaatgcttctagtaaaggggcgccatataatttaccaactacaccatggaatacattgaaggcctctgactcaaaggaaattgctcttatgacagcgaacaaactgggagacgggtaccaatgggttattaagtttaataaaaggacatgctccacatcaaatatgatcttttggtttgcattaccagcagaccaagtgccagtaggaagaactgactttgtaacagttaattcagatggaacaaatgtacaatggagtcatggagcaggagcaggtgcaaataaaccacttcaacaaatgtgggaatatggagtaaatgatcctcatcgttcacatgactttaaaataagaaatagaagtggccaagtaatatatgactggccaactgtccatatttattctttagaagatttatctagagcgagtgattattttagtgaagctggagcgacacctgctactaaagcttttggtagacaaaattttgaatatattaatggtcaaaaacctgctgaatcaccgggtgttcctaaagtttatactttcatcggtcaaggtgatgcaagttatacaatttcatttaaaacacaaggtccaactgttaataaattgtactatgcagcaggtgggcgtgctttagagtacaatcaattatttatgtacagtcaactatacgtcgaatcaacgcaagaccatcaacaacgtcttaatggtttaagacaagtggttaatcgtacatatcgcataggtacaactaaacgtgtagaagtgagtcaaggaaatgtacaaacgaaaaaggtattagaaagtacaaacctaaatatagatgattttgttgatgatcctttaagttatgttaagacgccgagtaataaagtgttaggattttattcgaataatgcaaatactaatgcttttagaccgggtggagcccaacaattaaatgaatatcaattaagtcaattatttactgatcaaaaattacaagaagcagcaagaactagaaacccaataagattaatgattggtttcgactatcctgatgcttatggtaatagtgaaactttagttcctgttaacttaacggtattacctgaaatccaacataatattaaattctttaaaaatgacgatactcaaaatattgctgaaaaaccattttcaaaacaagctgggcatccagttttctatgtatatgcaggtaaccaagggaatgcttccgtgaatttaggtggtagcgtaacatctattcaaccattacgtattaatttaacaagtaatgagaattttacagataaagattggcaaattacaggtattccgcgtacattacacattgaaaactcgacaaatagacctaataatgccagagaacgcaatattgaacttgttggtaacttattaccaggggattactttggaacgatacgttttggacgtaaagaacaattattcgaaattcgtgttaaaccacatacaccaacaattacaacgacagctgagcaattaagaggtacagcattacaaaaagtgcctgttaatatttcgggaataccgttggatccatcggcattggtttatttagttgcaccaacaaatcaaactacgaatggtggtagtgaggcagatcaaataccatctggttatacgatacttgcgactggtacacctgatggggtgcataatacaattactatacgaccgcaagattatgttgtattcataccacctgtaggtaaacaaattagagcagtagtttattataataaagtagttgcatctaatatgagtaatgctgttactattttgccagatgacattccaccaacaatcaataatcctgttggaataaatgccaaatactatcgaggcgacgaagtcaactttacaatgggtgtctctgatagacattctggtataaaaaatacaactattacgacattgccgaatggttggacatcaaatttaacaaaagcggataagaataatggctcattatctattacaggtagagtgagtatgaatcaggcatttaacagtgatattacatttaaagtgtcagcgacagacaatgtcaataatacgacaaatgatagtcaatctaaacatgtttcaattcatgtaggtaaaattagtgaagatgctcatccgattgtattaggaaatactgagaaagttgtagtagtcaatccgactgctgtatctaatgatgaaaagcaaagcataattactgcctttatgaataaaaaccaaaatataagaggatatttagcatcaactgatccagtaactgtcgataataatggtaatgtcacattacattaccgtgatggctcatcgacaacgcttgatgctacaaatgtgatgacatacgaaccagttgtgaaacctgaataccaaactgtcaatgctgctaaaacagcaacggtaacgattgctaaaggacaatcatttagtattggtgatattaaacaatattttactttaagtaatggacaacctattccaagtggcacatttacaaatattacatctgatagaactattccaactgcacaagaagttagtcaaatgaacgcaggcacgcagttataccatataactgctacaaatgcgtatcataaagatagtgaagacttctatattagtttgaaaatcatcgatgtgaaacaaccagaaggcgatcaacgtgtatatcgtacatcaacatatgatttaactactgatgaaatctcaaaagtaaaacaagcatttattaatgcaaatagagatgtaattacgcttgccgaaggtgatatttcagttacaaatacacctaatggtgctaatgtaagtactattacagtaaatattaataaaggtcgattaacgaaatcattcgcgtcaaacctagctaatatgaatttcttgcgttgggttaatttcccacaagattatacagtgacatggacgaatgcaaaaattgcaaacagaccaacagatggtggtttatcatggtctgatgaccataaatctttaatttatcgttatgatgctacattaggtactcaaattacgacgaatgatattttaacaatgttaaaagcaacaactacagtgcctggattgcgaaataacattactggtaatgaaaaatcacaagcagaagctggcggaagacctaactttagaacgactggttattcacaatcaaatgcgacaactgatggtcaacgtcaatttacgttgaatggtcaagtgattcaagtgttagacatcatcaacccttcaaacggttatggtgggcaacctgttacaaattcaaatactcgtgcaaaccatagtaactcaactgttgttaacgtaaacgaaccggcagctaatggtgctggcgcatttacaattgaccacgttgtaaaaagtaattctacacataatgcaagtgatgcagtttataaagcacagttatacttaacgccatatggtccaaaacaatatgttgaacatttaaatcaaaatacaggaaatactactgatgctattaacatttattttgtaccaagtgacttagtgaatccaacaatttcagtaggtaattacactaatcatcaagtgttctcaggtgaaacatttacaaatactattacagcgaatgataactttggtgtgcaatctgtaactgtaccaaatacatcacaaattacaggtactgttgataataaccatcaacatgtttctgcaacggcaccaaatgtgacatcagcaactaataagacaatcaatttattagcaactgatacaagcggcaatacagctacaacttcgttcaatgtaacagtgaaacctttgcgtgataaatatcgagttggtacttcatcaacggctgctaatcctgtgagaattgccaatatttcgaataatgcgacagtatcacaagctgatcaaacgacaattattaattcgttaacgtttactgaaacagtaccaaatagaagttatgcaagagcaagtgcgaatgaaatcactagtaaaacagttagtaatgtcagtcgtactggaaataatgccaatgtcacagtaactgttacttatcaagatggaacaacatcaacagtgactgtacctgtaaagcatgtcattccagaaatcgttgcacattcgcattacactgtacaaggccaagacttcccagcaggtaatggttctagtgcatcagattactttaagttatctaatggtagtgacattgcagatgcaactattacatgggtaagtggacaagcgccaaataaagataatacacgtattggtgaagatataactgtaactgcacatatcttaattgatggcgaaacaacgccgattacgaaaacagcaacatataaagtagtaagaactgtaccgaaacatgtctttgaaacagccagaggtgttttatacccaggtgtttcagatatgtatgatgcgaaacaatatgttaagccagtaaataattcttgggtcgacaatgcgcaacatatgaatttccaatttgttggaacatatggtcctaacaaagatgttgtaggcatatctactcgtcttattagagtgacatatgataatagacaaacagaagatttaactattttatctaaagttaaacctgacccacctagaattgacgcaaactctgtgacatataaagca |
ggtcttacaaaccaagaaattaaagttaataacgtattaaataactcgtcagtaaaattatttaaagcagataatacaccattaaatgtcacaaatattactcatggtagcggttttagttcggttgtgacagtaagtgacgcgttaccaaatggcggaattaaagcaaaatcttcaatttcaatgaacaatgtgacgtatacgacgcaagacgaacatggtcaagttgttacagtaacaagaaatgaatctgttgattcaaatgacagtgcaacagtaacagtgacaccacaattacaagcaactactgaaggcgctgtatttattaaaggtggcgacggttttgatttcggacacgtagaaagatttattcaaaacccgccacatggggcaacggttgcatggcatgatagtccagatacatggaagaatacagtcggtaacactcataaaacttgcggtgtaacattacctaatggtcaaggtacgcgtaatgttgaagttgcagtcaaagtttatccagttgctaatgcaaaggcgccatcacgtgatgtgaaaggtcaaaatttgactaatggaacggatgcgatgaactacattacatttgatccaaatacaaacacaaatggtatcactgcagcatgggcaaatagacaacaaccaaataaccaacaagcaggcgtgcaacatttaaatgtcgatgtcacatatccaggtatttcagctgctaaacgagttcctgttactgttaatgtatatcaatttgaattccctcaaactacttatacgacaacggttggaggcactttagcaagtggtacgcaagcatcaggatatgcacatatgcaaaatgctactggtttaccaacagatggatttacgtataaatggaatcgtgatactacaggtacaaatgacgcaaactggtcagctatgaataaaccgaatgtggctaaagtcgttaacgcaaaatatgacgtcatctataacggacatacttttgcaacatctttaccagcgaaatttgtagtaaaagatgtgcaaccagcgaaaccaactgtgactgaaacagcggcaggagcgattacaattgcacctggagcaaaccaaacagtgaatacacatgccggtaacgtaacgacatacgctgataaattagttattaaacgtaatggtaacgttgtgacgacatttacacgtcgcaataatacgagtccatgggtgaaagaagcatctgcagcaactgtagcaggtattgctggaactaataatggtattactgttgcagcaggtactttcaaccctgctgatacaattcaagttgttgcaacgcaaggaagcggagagacagtgagtgatgagcaacgtagtgatgatttcacagttgtcgcaccacaaccgaaccaagcgactactaagatttggcaaaatggtcatattgatatcacgcctaataatccatcaggacatttaattaatccaactcaagcaatggatattgcttacactgaaaaagtgggtaatggtgcagaacatagtaagacaattaatgttgttcgtggtcaaaataatcaatggacaattgcgaataagcctgactatgtaacgttagatgcacaaactggtaaagtgacgttcaatgccaatactataaaaccaaattcatcaatcacaattactccgaaagcaggtacaggtcactcagtaagtagtaatccaagtacattaactgcaccggcagctcatactgtcaacacaactgaaattgtgaaagattatggttcaaatgtaacagcagctgaaattaacaatgcagttcaagttgctaataaacgtactgcaacgattaaaaatggcacagcaatgcctactaatttagctggtggtagcacaacgacgattcctgtgacagtaacttacaatgatggtagtactgaagaagtacaagagtccattttcacaaaagcggataaacgtgagttaatcacagctaaaaatcatttagatgatccagtaagcactgaaggtaaaaagccaggtacaattacgcagtacaataatgcaatgcataatgcgcaacaacaaatcaatactgcgaaaacagaagcacaacaagtgattaataatgagcgtgcaacaccacaacaagtttctgacgcactaactaaagttcgtgcagcacaaactaagattgatcaagctaaagcattacttcaaaataaagaagataatagccaattagtaacgtctaaaaataacttacaaagttctgtgaaccaagtaccatcaactgctggtatgacgcaacaaagtattgataactataatgcgaagaagcgtgaagcagaaactgaaataactgcagctcaacgtgttattgacaatggcgatgcaactgcacaacaaatttcagatgaaaaacatcgtgtcgataacgcattaacagcattaaaccaagcgaaacatgatttaactgcagatacacatgccttagagcaagcagtgcaacaattgaatcgcacaggtacaacgactggtaagaagccggcaagtattactgcttacaataattcgattcgtgcacttcaaagtgacttaacaagtgctaaaaatagcgctaatgctattattcaaaagccaataagaacagtacaagaagtgcaatctgcgttaacaaatgtaaatcgtgtcaatgagcgattaacgcaagcaattaatcaattagtacctttagctgataatagtgctttaaaaactgctaagacgaaacttgatgaagaaatcaataaatcagtaactactgatggtatgacacaatcatcaatccaagcatatgaaaatgctaaacgtgcgggtcaaacagaatcaacaaatgcacaaaatgttattaacaatggtgatgcgactgaccaacaaattgccgcagaaaaaacaaaagtagaagaaaaatataatagcttaaaacaagcaattgctggattaactccagacttggcaccattaacaaactgcaaaactcagttgcaaaatgatattgatcagccaacgagtacgactggtatgacaagcgcaatctattgcagcatttaatgaaaactttcagcagctagaactaaaattcaagaaattgatcgtgtattagcctcacatccagatgttgcgacaatacgtcaaaacgtgacagcagcgaatgccgctaaatcagcacttgatcaagcacgtaatggcttaacagtcgataaagcgcctttagaaaatgcgaaaaatcaactacaatatagtattgacacgcaaacaagtacaactggtatgacacaagactctataaatgcatacaatgcgaagttaacagctgcacgtaataagattcaacaaatcaatcaagtattagcaggttcaccgactgtagaacaaattaatacaaatacgtctacagcaaatcaagctaaatctgatttagatcatgcacgtcaagctttaacaccagataaagcgccgcttcaaactgcgaaaacgcaattagaacaaagcattaatcaaccaacggatacaacaggtatgacgaccgcttcgttaaatgcgtacaaccaaaaattacaagcagcgcgtcaaaagttaactgaaattaatcaagtgttgaatggcaacccaactgtccaaaatatcaatgataaagtgacagaggcaaaccaagctaaggatcaattaaatacagcacgtcaaggtttaacattagatagacagccagcgttaacaacattacatggtgcatctaacttaaaccaagcacaacaaaataatttcacgcaacaaattaatgctgctcaaaatcatgctgcgcttgaaacaattaagtctaacattacggctttaaatactgcgatgacgaaattaaaagacagtgttgcggataataatacaattaaatcagatcaaaattacactgacgcaacaccagctaataaacaagcgtatgataatgcagttaatgcggctaaaggtgtcattggagaaacgactaatccaacgatggatgttaacacagtgaaccaaaaagcagcatctgttaaatcgacgaaagatgctttagatggtcaacaaaacttacaacgtgcgaaaacagaagcaacaaatgcgattacgcatgcaagtgatttaaaccaagcacaaaagaatgcattaacacaacaagtgaatagtgcacaaaacgtgcaaacagtaaatgatattaaacaaacgactcaaagcttaaatactgctatgacaggtttaaaacgtggcgttgctaatcataaccaagtcgtacaaagtgataattatgtcaacgcagatactaataagaaaaatgattacaacaatgcatacaaccatgcgaatgacattattaatggtaatgcacaacatccagttataacaccaagtgatgttaacaatgctttatcaaatgtcacaagtaaagaacatgcattgaatggtgaagctaagttaaatgctgcgaaacaagaagcgaatactgcattaggtcatttaaacaatttaaataatgcacaacgtcaaaacttacaatcgcaaattaatggtgcgcatcaaattgatgcagttaatacaattaagcaaaatgcaacaaacttgaatagtgcaatgggtaacttaagacaagctgttgcagataaagatcaagtgaaacgtacagaagattatgcggatgcagatacagctaaacaaaatgcatataacagtgcagtttcaagtgccgaaacaatcattaatcaaacaacaaatccaacgatgtctgttgatgatgttaatcgtgcaacttcagctgttacttctaataaaaatgcattaaatggttatgaaaaattagcacaatctaaaacagatgctgcaagagcaattgatgcattaccacatttaaataatgcacaaaaagcagatgttaaatctaaaattaatgctgcatcaaatattgctggcgtaaatactgttaaacaacaaggtacagatttaaatacagcgatgggtaacttgcaaggtgcaatcaatgatgaacaaacgacgcttaatagtcaaaactatcaagatgcgacacctagtaagaaaacagcatacacaaatgcggtacaagctgcgaaagatattttaaataaatcaaatggtcaaaataaaacgaaagatcaagttactgaagcgatgaatcaagtgaattctgctaaaaataacttagatggtacgcgtttattagatcaagcgaagcaaacagcaaaacagcagttaaataatatgacgcatttaacaactgcacaaaaaacgaatttaacaaaccaaattaatagtggtactactgtcgctggtgttcaaacggttcaatcaaatgccaatacattagatcaagccatgaatacgttaagacaaagtattgccaacaaagatgcgactaaagcaagtgaagattacgtagatgctaataatgataagcaaacagcatataacaacgcagtagctgctgctgaaacgatt 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gataaatcgactggtcaaaacttaactgcaaaacaagttatcaaattaaatgatgcagtcactgcagctaagaaagcattaaatggtgaagaaagacttaataatcgtaaagctgaagcattacaaagattggatcaattaacacatctaaacaatgctcaaagacaattagcaatccaacaaattaataatgctgaaacgctaaataaagcatctcgagcaattaatagagcaactaaattagataatgcaatgggtgcagtacaacaatatattgacgaacagcaccttggtgttatcagcagcacaaattacatcaatgcagatgacaatttgaaagcaaattatgataatgcaattgcgaatgcagcacatgagttagataaagtgcaaggtaatgcaattgcaaaagctgaagcagagcaattgaaacaaaatattatcgatgctcaaaatgcattaaatggagaccaaaaccttgcaaatgccaaagataaagcaaatgcgtttgttaattcgttaaatggattaaatcaacagcaacaagatcttgcacataaagcaattaacaatgccgatactgtatcagatgtaacagatattgttaataatcaaattgacttaaatgatgcaatggaaacattgaaacatttagttgacaatgaaattccaaatgcagagcaaactgtcaattaccaaaacgctgacgataatgctaaaacaaacttcgatgatgccaaacgtctagcaaatacattgctaaatagtgataacacaaatgtgaatgatatcaatggcgcaatccaagcagtcaatgatgcaatccataatcttaatggtgatcaacgactacaagatgctaaagacaaggcaattcaatctattaatcaagctttagctaataagctaaaagaaatcgaagcttcaaatgcgacggatcaagacaagcttattgcgaaaaataaagcagaagaattggcaaacagcatcatcaacaacattaataaagcaacaagtaatcaggctgtatctcaagttcaaacagcaggcaaccacgcgattgaacaagtgcatgccaatgaaataccaaaagcaaaaattgatgccaataaagacgttgataagcaagttcaagcattaattgacgaaattgatcgaaatccaaatctaacagataaggaaaaacaagcacttaaagatcgtattaatcaaatacttcaacaaggtcataacggcattaacaatgcgatgactaaagaagaaattgaacaagccaaagcacaacttgcgcaagcattacaagacatcaaagatttagtgaaagctaaagaagatgcgaaacaagatgttgataaacaagttcaagctttaattgacgaaatcgatcaaaatccaaatctaacagataaggaaaaacaagcacttaaagatcgtattaatcaaatacttcaacaaggtcatarcgacattamcaatgcgatgacaaaagaagcaattgaacaagcaaaagaacgtttagcgcaagcattgcaagacatcaaagatttagtgaaagctaaagaagatgcgaaaaatgatattgataaacgtgtacaagctttaattgacgaaatcgatcaaaatccaaaaataacagataaggaaaaacaagcacttaaagatcgaattaatcaaatacttcaacaaggtcataacgacattaacaatgcgctgactaaagaagaaattgagcaggcaaaagcacaacttgcacaagcattgcaagacatcaaagatttagtgaaagctaaagaagatgcgaaaaatgcaataaaagccttagctaatgcgaagcgtgatcaaatcaattcaaatccagatttaacacctgagcaaaaagcaaaagcgctcaaagaaattgacgaagctgaaaaacgagcactacaaaacgttgagaatgctcaaactatagatcaattaaatcgaggattaaacttaggtttagatgacattagaaatacacatgtatgggaggttgatgaacaacctgctgtaaatgaaatttttgaagcaacacctgagcaaatcctagttaatggtgaactcattgtacatcgtgatgacatcattacagaacaagatattcttgcacacataaacttaattgatcagctttcagcagaagtcatcgatacaccatcaactgcaacgatttctgatagcttaacagcaaaagttgaagttacattgcttgatggatcaaaagtgattgttaatgttcctgtaaaagttgtagaaaaagaattgtcagtagtcaaacaacaggcaattgaatcaatcgaaaatgcggcacaacaaaagattaatgaaatcaataatagtgtgacattaacactggaacaaaaagaagctgcaattgcagaagttaataagcttaaacaacaagcaattgatcatgttaacaatgcacctgatgttcattcagttgaagaaattcaacaacaagaacaagcgcatattgaacaatttaatccagaacaatttacgattgaacaagcaaaatcaaatgcaattaaatcgattgaagatgcaattcaacatatgattgatgaaatcaaagctcgtactgatctaacagataaagagaagcaagaagctattgctaagttaaatcaattaaaagaacaagcaattcaagcgattcaacgtgcgcaaagcatcgatgaaataagtgagcaattggaacaatttaaagctcaaatgaaagcagctaatccaacagcaaaagaactagctaaacgcaagcaagaagctattagtagaattaaagacttttcaaatgaaaaaataaatagtattcgaaatagtgaaattggcacagctgatgaaaaacaagcagcaatgaatcaaattaacgaaattgtgcttgaaacaattagagatattaataatgcgcatacattacagcaagttgaggctgcattgaacaatggtattgctcgaatttcagcagtacaaattgtaacatctgatcgtgctaaacaatcgtcaagtactggaaatgaatctaatagccatttaacaattggttatggaactgcaaatcatccatttaacagttcgactattggacataaaaagaaacttgatgaagatgatgacattgatccacttcatatgcgtcactttagtaataatttcggtaatgttattaaaaacgctattggtgtggtgggtatctctggtttactagctagtttctggttcttcattgccaaacgtcgtcgtaaagaagatgaagaggaagaattagaaataagagataataataaagattcaataaaagagactttagacgatacaaaacatttaccacttttatttgcgaaacgtcgcagaaaagaagatgaagaagatgttactgttgaagaaaaagattcgctaaataatggcgagtcactcgataaagttaaacatacgccgttcttcttaccaaaacgtcgtcgtaaagaagatgaagaagatgtggaagttacaaatgaaaacacagatgaaaaagtgttgaaagataacgaacattcaccactcttattcgcaaaacgacgcaaagataaagaggaagatgttgaaacaacaactagtattgaatctaaagatgaggacgttcctttattattggctaaaaagaaaaatcaaaaagataaccaatccaaagacaaaaagtcagcatcaaaaaatacttctaaaaaggtagcagctaaaaagaagaaaaagaaagctaagaaaaataaaaaataa |
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dekvtaaenivsgtptptltpadvtaaatqvtnaktqlngnhnlevakqnantaidgltslngpqkaklkeqvgqattlpnvqtvrdnaqtlntamkglrdsianeatikagqnytdasqnkqtdynsavtaakaiigqttspsmnaqeinqakdqvtakqqalngqenlrtaqtnakqhlnglsdltdaqkdavkrqiegathvnevtqaqnnadalntamtnlkngiqdqntikqgvnftdadeakrnaytnavtqaeqilnkaqgqntakdgvetalenvqraknelngnqnvanakttaknalnnltsinnaqkealksqiegattvagvnqvsttaselntamsnlqngindeaatkaaqkytdadrekqtayndavtaaktlldktagsndnkaaveqalqrvntaktalngderlneakntakqqvatmshltdaqkanltsqiesgttvagvqgiqanagtldqamnqlrqsiaskdatkssedyqdanadlqnayndavtnaegiisatnnpesmpdtinqkasqvnsaksalngdeklaaakqtaksdigrltdlnnaqrtaanaevdqapnlaavtaaknkatslntamgnlkhalaekdntkrsvnytdadqpkqqaydtavtqaeaitnangsnanetqvqaalnqlnqakndlngdnkvaqakesakralasysnlnnaqstaatsqidnattvagvtaaqntanelntamgqlqngindqntvkqqvnftdadqgkkdaytnavtnaqgildkahgqnmtkaqveaalnqvttaknalngdanvrqaksdakanlgtlthlnnaqkqdltsqiegattvngvngvktkaqdldgamqrlqsaiankdqtkasenyidadptkktafdnaitqaesylnkdhgankdkqaveqaiqsvtstenalngdanlqrakteaiqaidnlthlntpqktalkqqvnaaqrvsgvtdlknsatslnnamdqlkqaiadhdtivasgrrytnaspdkqgaytdynaaknivngspnvitnaadvtaatqrvnnaetglngdtnlatakqqakdalrqmthlsdaqkqsitgqidsatqvtgvqsvkdnatnldnamnqlrnsiankddvkasqpyvdadrdkqnayntavtnaeniinataqptldpsavtqaanqvstnktalngaqnlankkqettaninqlshlnnaqkqdlntqvtnapnistvnqvktkaeqldqamerlingiqdkdqvkqsvnftdadpekqtaynnavtaaeniinqangtnanqsqveaalstvtttkqalngdrkvtdaknnanqtlstldnlnnaqkgavtgninqahtvaevtqaiqtaqelntamgnlknslndkdttlgsqntadadpekknayneavhnaenilnkstgtnvpkdqveaamnqvnatkaalngtqnlekakqhantaidglshltnaqkealkqlvqqsttvaeaqgneqkannvdaldklrrqsiadnattkqnqnytdasqnkkdaynnavttaqgiidqttsptldptvinqaagqvsttknalngnenleaakqqasqslgsldnlnnaqkqtvtdqingahtvdeanqikqnaqnlntamgnlkqaiadkdatkatvnftdadqakqqayntavtnaeniiskanggnatqaeveqaikqvnaakqalngnanvqhakdeatalinssndlnqaqkdalkqqvqnattvagvnnvkqtaqelnnamtqlkqgiadkeqtkadgnfvnadpdkqnaynqavakaealisatpdvvvtpseitaalnkvtqakndlngntnlatakqnvqhaidqlpnlnqaqrdeyskqitqatlvpnvnaiqqaattlndamtqlkqgiankaqikgsenyhdadtdkqtaydnavtkaeellkqttnptmdpntiqqaltkvndtnqalngnqkladakqdakttlgtldhlndaqkqalttqveqapdiatvnnvkqnaqnlnnamtnlnnalqdktetlnsinftdadqakkdaytnavshaegilskangsnasqteveqamqrvneakqalngndnvqrakdaakqvitnandlnqaqkdalkqqvdaaqtvanvntikqtagdlnqamtqlkqgiadkdqtkangnfvnadtdkqnaynnavahaeqiisgtpnanvdpqqvaqalqqvnqakgdlngnhnlqvakdnantaidqlpnlnqpqktalkdqvshaelvtgvnaikqnadalnnamgtlkqqiqansqvpqsvdftqadqdkqqaynnaanqaqqiangiptppvltpdtvtqavttmnqakdalngdeklaqakqealanldtlrdlnqqrdalrnqinqaqalatveqtkqnaqnvntamsnlkqgianktvkkasenyhdadadkqtaytnavsqaegiinqttaptlnpdeitraltqvtdaknglngeaklatekqnakdavsgmthlndaqkqalkgqidqspeiatvnqvkqtatsldqamdqlsqaindkaqtladgnylnadpdkqnaykqavakaeallnkqsgtnevqaqvesitnevnaakqalngndnlanakqqakqqlanlthlndaqkqsfesqitqaplvtdvttinqkaqtldhamellnsvadnqttlasedyyhdataqrqndynqavtaanniinqttsptmnpddvngattqvnntkvaldgdenlaaakqqannrldqldhlnnaqkqqlqsqitqssdiaavnghkqtaeslntamgnlinaiadhqaveqrgnfinadtdkqtayntavneaaaminkqtgqnanqteveqaitkvqttlqalngdhnlqvaktnatqaidaltslndpqktalkdqvtaatlvtavhqieqnantlnqamhglrqsiqdnaatkanskyinedqpeqqnydqavqaanniineqtatldnnainqaattvnttkaalhgdvklqndkdhakqtvsqlahlnnaqkhmedtlidsettrtavkqdlteaqaldqlmdalqqsiadkdatrassayvnaepnkkqsydeavqnaesiiaglnnptinkgnvssatqavissknaldgverlaqdkqtagnslnhldqltpaqqqalenqinnattrgevaqklteaqalnqamealrnsiqdqqqteagskfinedkpqkdayqaavqnakdlinqtnnptldkaqveqltqavnqakdnlhgdqkladdkqhavtdlnqlnglnnpqrqalesqinnaatrgevaqklaeakaldqamqalrnsiqdqqqtesgskfinedkpqkdayqaavqnakdlinqtgnptldksqveqltqavttakdnlhgdqklardqqqavttvnalpnlnhaqqqaltdainaaqtrtevaqhvqtateldhametlknkvdqvntdkaqpnyteastdkkeavdqalqaaesitdptngsnankdavdqvltklqekenelngnervaeaktqakqtidqlthlnadqiatakqnidqatklqpiaelvdqatqlnqsmdqlqqavnehanveqtvdytqadsdkqnaykqaiadaenvlkqnankqqvdqalqnilnakqalngdervalaktngkhdidqlnalnnaqqdgfkgridqsndlnqiqqivdeakainramdqlsqeitdnegrtkgstnyvnadtqvkqvydetvdkakqaldkstgqnltakqviklndavtaakkalngeerlnnrkaealqrldqlthlnnaqrqlaiqqinnaetlnkasrainratkldnamgavqqyideqhlgvisstnyinaddnlkanydnaianaaheldkvqgnaiakaeaeqlkqniidaqnalngdqnlanakdkanafvnslnglnqqqqdlahkainnadtvsdvtdivnnqidlndametlkhlvdneipnaeqtvnyqnaddnaktnfddakrlantllnsdntnvndingaiqavndaihnlngdqrlqdakdkaiqsinqalanklkeieasnatdqdkliaknkaeelansiinninkatsnqavsqvqtagnhaievhhaneipkakidankdvdkqvqalideidrnpnltdkekqalkdrinqilqqghnginnamtkeeieqakaqlaqalqdikdlvkakedakqdvdkqvqalideidqnpnltdkekqalkdrinqilqqghxdixnamtkeaieqakerlaqalqdikdlvkakedakndidkrvqalideidqnpnltdkekqalkdrinqilqqghndinnaltkeeieqakaqlaqalqdikdlvkakedaknaikalanakrdqinsnpdltpeqkakalkeideaekralqnvenaqtidqlnrglnlglddirnthvwevdeqpavneifeatpeqilvngelivhrddiiteqdilahinlidqlsaevidtpstatisdsltakvevtlldgskvivnvpvkvvekelsvvkqqaiesienaaqqkineinnsvtltleqkeaaiaevnklkqqaidhvnnapdvhsveeiqqqeqahieqfnpeqftieqaksnaiksiedaiqhmideikartdltdkekqeaiaklnqlkeqaiqaiqraqsideiseqleqfkaqmkaanptakelakrkqeaisrikdfsnekinsirnseigtadekqaamnqineivletirdinnahtlqqveaalnngiarisavqivtsdrakqssstgnesnshltigygtanhpfnsstighkkkldedddidplhmrhfsnnfgnviknaigvvgisgllasfwffiakrrrkedeeeeleirdnnkdsiketlddtkhlpllfakrrrkedeedvtveekdslnngesldkvkhtpfflpkrrrkedeedvevtnentdekvlkdnehspllfakrrkdkeedvetttsieskdedvplllakkknqkdnqskdkksaskntskkvaakkkkkkakknkk |
441. | atgttctttgatgatgctaaagaagcatcaagagtacttgaaataacattgacgaaaagagatgctaaaaaagaaaatcctattccgatgtgtggcgtaccatatcattctgctgataattacattgaaacattgattaataaggggtataaggtcgctatatgtgaacaaatggaagatccaaagcaaacaaaaggaatggttagaagagaagttgtaagaatcatcacaccaggaactgttatggatcaaaatggtatggatgaaaagaaaaataattatattttaagttttatcgaaaatgaagaatttggattatgctattgtgatgtttctacaggagaactcaaagtaactcatttcaaagatacagcaaccttgcttaatgagattacaacaattaatcccaatgaaatcgtcataaagcaagctctatctgaagaattaaaaagacaaatcaacatgataactgagacgattactgttcgcgaagatatatctgatgaagattatgatatgaatcagttgacacatcagttaatgcatgacacaactcaattattgttagattacattcatcacacacaaaagcgagatttatctcatattgaggaagtaattgaatatgctgcagttgattatatgaagatggattattatgcgaagcgaaatttagagctgacagagagcatacgattaaaatcaaaaaaagggactttgttatggttaatggatgagacaaaaacaccgatgggtgctagacgtttaaagcagtggattgatcgtccattaattaataaacaacaaatcaacgacagattaaatattgttgaagagtttatggaccgttttattgaaagagatacattacgtaatcatttaaatcaagtgtatgacatagaacgactagtaggaagagtgagttatggaaacgtaaatgcaagagatttaatacaacttaagcattctatatccgaaatacctcacattaaagcattactcaatgaattgggtgcacaaactaccacgcaatttaaagaattagaacctttagatgacttgttacaaattttagaagaaagtttagttgaagaaccacctatttccatcaaagatggaggattatttaaaaatggcttcaacgcgcaacttgatgaatatttagaagcttcaaaaaatggtaaaacttggcttgcagaattacaagctaaggaacgtgaacgtacaggtattaagtcattgaaaattagttttaataaagtgtttggttattttattgaaattacacgtgcaaacttaaataattttcaacctgaagcgtttggctataatcgaaaacaaacattatctaatgctgaacgatttattacggatgaattaaaagaaaaagaagatataatacttggtgctgaagataaagcagtagagttagaatatgaattatttgttaaattacgagaacacattaaaacgtacactgaacgtttacaaaagcaagcgaaaatcatttcagaacttgattgtttacaaagttttgctgaaattgctcaaaaatataattatgtcaaacctacatttagtgatgataaagttttacatttagaaaactcaagacatcctgttgttgagagagtgatggattataatgattatgtacctaatgattgccatcttgatgatgaaacgtttatttatctcattacgggacctaatatgtcaggtaagtcaacatatatgagacaagttgctataataagtatcatggctcaaatgggagcatatgtaccatgtgattcagcaacattacctatatttgatcaaatttttactaggattggtgcagcagatgatcttgtatcaggtaaaagtacatttatggtagaaatgttagaagctcaaaaagctttaacttatgctactgaaaatagtttaattatctttgacgaaataggaagaggtacatccacttatgatggtcttgcgttagcgcaagcgatgattgaatatgttgctcaaacttcccatgctaagacacttttctcaacacattatcatgaattgacatcacttgatcaaatgcttaagtgtttaaaaaatgtacatgttgctgcaaacgagtatcaaggtgaactgatatttttgcataaagtcaaagatggcgctgtggatgatagctatggtattcaagtggcaaaattagcggatttacctaatgaagtcattgatagagcgcaagttatattaaatgcatttgagcaaaaaccttcgtatcaactctctcatgagaatactgacaatcaacaaacggttccgtcgtataacgattttggtcgaacagaagaagagcaatcagttatagaaacacatacatcaaatcataattatgagcaagcgacctttgatttatttgatggttacaatcaacaaagtgaagttgaatgtcaaattcgagaattgaatctatccaatatgacaccattggaagccttaatcaagctgaatgaattacaaagtcaattaaag |
442. | mffddakeasrvleitltkrdakkenpipmcgvpyhsadnyietlinkgykvaiceqmedpkqtkgmvrrevvriitpgtvmdqngmdakknnyilsfieneefglcycdvstgelkvthfkdtatllneittinpneivikqalseelkrqinmitetitvredisdedydmnqlthqlmhdttqqllldyihtqkrdlshieevieyaavdymkmdyyakrnleltesirlkskkgtllwlmdetktpmgarrlkqwidrplinkqqindrlniveefmdrfierdtlrnhlnqvydierlvgrvsygnvnardliqlkhsiseiphikallnelgaqtttqfkeleplddllqileeslveeppisikdgglfkngfnaqldeyleaskngktwlaelqakerertgikslkisfnkvfgyfieitranlnnfqpeafgynrkqtlsnaerfitdelkekediilgaedkaveleyelfvklrehiktyterlqkqakiiseldclqsfaeiaqkynyvkptfsddkvlhlensrhpvvervmdyndyvpndchlddetfiylitgqnmsgkstymrqvaiisimaqmgayvpcdsatlpifdqiftrigaaddlvsgkstfmvemleaqkaltyatensliifdeigrgtstydglalaqamieyvaqtahaktlfsthyheltsldqmlkclknvhvaaneyqgeliflhkvkdgavddsygiqvakladlpnevidraqvilnafeqkpsyqlshentdnqqtvpsyndfgrteeeqsviethtsnhnyeqatfdlfdgynqqsevecqirelnlsnmtplealiklnelqsqlk |
443. | atgattccaactaaacctcatgatgtgatttggacagatgcacaatggcaaagtatttatgcgaaaggacaggacatacttgttgctgctgcagcaggttccggtaaaacagccgttctagttgagcgtattatacaacgtatactaagagatgatgtagatgtagatcggttactagttgtaacatttacgaatttaagcgcacgtgagatgaagcatcgagttgataaacgtatacaagaagcatcttttaaggatcctaacaatgaacatttaaagaatcagcgaatcaaaattcatcaagcacagatttctactttacacagtttctgtttgaaattgattcagcagcattatgatgtattagatatcgatcctcattttagaacaagtagtgaagcggaaaatatattattattagaacaaactattgatgatgttttagaacaacactatgataaattagatcctcactttatagaattaaccgaacaactatcatcagataggaatgatgatcaatttagaagtattattaagcagttatattttttcagtattgctaatcctcaaccatttgaatggctcaatcaattagcgcaaccatacaaagaagaaaataaacagcaacaattaatgcagcttatcaatgatttagcaatgatttttatgaaagcaggatatgaggaattacaaaaaagttatgacttattctcaatgatggaaagtgttgataagcagcttgaagttattgaaaccgaacgcatgtttattactaaagctattgaaggtaaagtattaaatacagatgttatcacgcaacatgaatttatgagtcgttttccggcaataaatagcaagataaaagaagcaaatgaaggcatggaagatgctttaaatgaagcaaaacaacattatgataaatataaatctttagttatgaaagtaaagaatgattatttttctagaaatgcagaagatttgcaaagagatatgcaacaactcgcacctcgagtggcttatttagctcaaatagttcaagatgtgattcaatcatttggtgttcaaaaacgaagtcgtaatattttggatttttcagattatgaacattttgcattacgcattcttactaacgaagatggctcaccttcgcgtatcgctgaaacgtatcgtgaacattttaaagaaatcctagttgatgagtatcaagatactaatagagtgcaagaaaaaatattatcttgtattaaaactggtgaagaacacgatggtaacttgttcatggttgggggatgtgaagcagtctatttataatttagacaagctgatcctagtttatttattgaaaaatataatcgcttttctagtagtggaaatgaaagtggcttgcgcattgacttatcgcaaactttcgttcgagacagggaagtgttatctacaaccaattacttgttcaaacatatgatggatgaacaagtaggagaaatttcatatgatgatgcagcgcaattgtattttggtgcaccatatgacgaagtttcacatcctgttcaattacgagcacttgttgaggcaagttcagaaaatagtgacttaactggaagtgaacaagaagcgaattacattgttgaacaagttaaagatattattaatcatcaaaacgtatacgatatgaaaacaggtcaatacagaaaagcaacatataaagatatcgtaattttagagcgaagttttggtcaagcgcgtaatcttcaacaagcttttaaaaataatgatatcccttttcacgtaaatagtaaggaagggtattttgagcaaactgaagtacgtcttgtgctttcatttttaagaacaatagataatccacttcaagacatttatttagtgggattgatgcgttctgtaatatatcaatttactgaagaagaattagctgaaataagagttgtaagccctcatgatgattacttttatcaatctataaaaaattatatgattgatgaaaaagctgattctagattggttgacaagttaaatcgttttattcaggatatacaaaaatatcaaaattatagtcaaagtcaaccggtttaccaattaattgataaattttataatgatcattttgtaattcagtactttagcggtcttattggaggtaaaggtagaagagcaaatctgtatgggctatttaataaagctgttgaatttgaaaattcaagtttcagaggtttattccaatttattcgttttattgatgagcttattgatcgtaaaaaagattttggtgaagaaaatgtcgtaggtcctaacgataatgtggttagaatgatgacgattcacagtagtaaaggattagaatttccatttgtaatttactcaggattatctaaaaaattcaacaaaggtgacctgaatgcaccagttattctaaatcaacaatatggtttaggtatggattattttgatgtaaataaagatatggcttttccttcacttgcctctgtggcatatagagcaataaatgaaaaagaacttatatcagaagagatgcgtttaatctatgttgcgttgacacgagcaaaagagcaacttattttagttggaagagtcaaagatgaaaagtcgttaattaaatatgaacaattagctgtttcagacacacatatagcagttaatgaacgccttactgctaccaatccatttgttctaatttatggtgttttggctaagcatcaatcgccttcattgccaaatgatcaaagatttgaaagagatattgatcaattaaattctgaagtgaagccacgtgtatcaatagtgattgatcattatgaggatgtttcaactgaagaagtagtcaatgataatgaaataagaacaatcgaagaattaaaggccataaatactggtaatgaagatgtgaaaattaaaattcatcaacagctttcttatgactatccttttaaagttaacacgatgaaaccatctaaacagtcggtatcagagttaaaacgtcaattagaaactgaagaaagtaatacaaattatgatagagtacgtcaatatcgtattggtgttgcatcatatgaaagacccaagtttcttacccaaacaaaaaaaagaaaagcaaatgaaatagggactttaatgcatacagtcatgcaacacttaccttttagagaacaacgtttaacaaaagacgaattatttcaatatatcgatcgattgattgacaaacaacttattgatgaagatgcaaaagaggatattagaatagatgagattatgcatttcattgatggccctctctatatggaaatagctcaagctgacaatgtttatactgaattaccttttgtggtaaatcaaattaaagttgatggacttacaagtgaagatgaagatgtatccattattcaaggtatgattgatttaatatatgaaagtgacggacaattttactttgttgattacaaaacagatgcttttaatagaagaaaaggtatgagtgatgaagaaatagggaatcagctcaaagaaaaatatcagatacaaatgacgtattatcgaaatactttagaaaccatacttaaacgacccgtaaagggttacttatattttttcaaatttggtacattagaaatagatgat |
444. | miptkphdviwtdaqwqsiyakgqdilvaaaagsgktavlveriiqrilrddvdvdrllvvtftnlsaremkhrvdkriqeasfkdpnnehlknqrikihqaqistlhsfclkliqqhydvldidphfrtsseaenillleqtiddvleqhydkldphfielteglssdrnddqfrsiikqlyffsianpqpfewlnqlaqpykeenkqqqlmqlindlamifmkagyeelqksydlfsmmesvdkqlevietermfitkaiegkvlntdvitqhefmsrfpainskikeanegmedalneakqhydkykslvmkvkndyfsrnaedlqrdmqqlaprvaylaqivqdviqsfgvqkrsrnildfsdyehfalriltnedgspsriaetyrehfkeilvdeyqdtnrvqekilsciktgeehdgnlfmvgdvkqsiykfrqadpslfiekynrfsssgnesglridlsqnfrsrqevlsttnylfkhmmdeqvgeisyddaaqlyfgapydevshpvqlralveassensdltgseqeanyiveqvkdiinhqnvydmktgqyrkatykdivilersfgqarnlqqafknndipfhvnskegyfeqtevrlvlsflrtidnplqdiylvglmrsviyqfteeelaeirvvsphddyfyqsiknymidekadsrlvdklnrfiqdiqkyqnysqsqpvyqlidkfyndhfviqyfsgliggkgrranlyglfnkavefenssfrglfqfirfidelidrkkdfgeenvvgqndnvvrmmtihsskglefpfvviyslskkfnkgdlnapvilnqqyglgmdyfdvnkdmafpslasvayrainekeliseemrliyvaltrakeqlilvgrvkdekslikyeqlavsdthiavnerltatnpfvliygvlakhqspslpndqrferdidqlnsevkprvsividhyedvsteevvndneirtieelkaintgnedvkikihqqlsydypfkvntmkpskqsvselkrqleteesntnydrvrqyrigvasyerpkfltqtkkrkaneigtlmhtvmqhlpfreqrltkdelfqyidrlidkqlidedakedirideimhfidgplymeiaqadnvytelpfvvnqikvdgltsededvsiiqgmidliyesdgqfyfvdyktdafnrrkgmsdeeignqlketyqiqmtyyrntletilkrpvkgylyffkfgtleidd |
445. | ctgtaccatcaaatggtgctacaatttctcctgaatctggtacaaatccgataccatcacccatcatcttttcagagaaaactttatcaggtacttcagataacggtattatctcaccatgtccaggtgcgtaaatttctgtttctacaatatcttccacatgtacaggatcatctgacacttcttcatcaattgttgtttcacttggttttg |
446. | lyhqmvlqfllnlvqiryhhpssfqrklyqvlqitvlshhvqvrkflflqylphvqdhitllhqllfhlvl |
447. | cgcatactttggtcatcactatgcgtaatccacaaaatggcaatccctttatctgctagtttaaatataatttcttcaattttctttttattatgtgtatctaaagcgctagtagcttcgtccaataataaaacttcaggttcatacatgagttgtctagcgatggtaatacgttgttgctctcccccagacatgtgctcaatt |
448. | rilwsslcvihkmaiplsaslniissiffllcvskalvassnnktsgsymsclamvirccsppdmcsi |
449. | tcacgtactttacgcgctctactcttaatactccaaacaggcatgatgtgtggtttgttatggtcatcatctgaaatcataataaaattcttttcacctttgtttgtcaatccgtatacttcgtcatattttgcgacatctttaataaactctctcattcttatatcatctaattcagacatcaactcatcagtcattttaactatatctacaatgtttccttcttcaccattattcacattaactaaaactttgtcacctggatcaaagatttcatccatttcatatgttacaaaacggtcaatatctgctctaatgattttgtcg |
450. | srtlralllilqtgmmcgllwssseiiikffsplfvnpytssyfatslinslilissnsdinssviltlstmtpssplttltktlspgskissisyvtkrsisalmils |
451. | gcaggatttttgactaaagcagtacttaaatcaacttcatctctgtcatcaaacacttcttctacgacttctttacgtgcaatcaccctaaatgaaccttcgtccacatttaattctactcttacatttctggcactatca |
452. | agfltkavlkstsslssntssttslraitlnepssifnstltflals |
453. | tatttctttataagctttttaattagactaatatcatgctcattgattaccgaaacaatttcgatttgtccatttttagatataattgagccattaccaccaatcaaggtatcatccgcaaattcaggaatgactggaagcaagtctctaatgggacgtgctgatgcaaacattacattg |
454. | yffisflirliscslitetisicpfldiieplppikvssansgmtgskslmgradanitl |
455. | ttatcttcttctaaagctttaccttcaacgtcaacgtttggcaatactgcacctaaccatttaggaaggttaccatgaagctttaccaaagagttcgtcaatgctggaattaatgtcatacgtacgacgaatgcgtcgaataacacaccgaaacctaatgcgatacccattgacttaattgcactgtcatcttggaagacgaatgcgatgaatacactgaacataataagtgcagcagctacgataacaggtccactttctttgatacctacacggattgaa |
456. | lssskalpststfgntapnhlgryhealpksfvnaginvirttnasnntpkpnaipidlialsswktnamntlniisaaatitgplsliptrie |
457. | tcatcaactgcttgcattaagtctaagattttttgttcgtattcagcatcgccttctaatgcttttaatgcagaaccagcgattacaggcacatcgtcacctgggaagtcatattcgcttaataagtcacgaacttccatttcaactaattctaataattcttcgtcgtctaccatgtcaactttgttcaagaatacaactaacgctggtacaccaacgttacgtgataataagatgtgttcacgagtttgtggcattggaccgtcagcagcagatacaactaagataccgccgtccatttga |
458. | sstacikskifcsysaspsnafnaepaitgtsspgksyslnksrtsistnsnnnssstmstlfknttnagtptlrdnkmcsrvcgigpsaadttkippsi |
459. | ttagaaccacctacacgacgagctttaacttctaatactggcatgatattattaattgcttcttcgaacacttctaatgcatcacgaccactacgttgttcaacaagatcaaatgcagaa |
460. | lepptrraltsntgmilliassntsnasrplrcstrsnae |
461. | aggaggcgaccgccccagtcaaactgcccgcctgacactgtctcccaccacgataagtggtgcgggttagaaagccaacacagc |
462. | rrrppqsncppdtvshhdkwcglesqhs |
463. | tgtgctattattccccctattgaaggacctaacccttcacctaaagctacaattgatcctataaaaccaaaggctttgccttgtttttttcttgtaatatttctagctacaaccaccataatcagtgaagggaatgcagcagatcctactccttgtactaacctaccaaaaatcaaaataaaaaag |
464. | gccagtcacttctcgttccatttgattcaatacaaacaaattatcttgaacatcttccgaagcactgccgccagtatccttgctttttttttgctgttgtccacaatttatttccgcacggtcaaattttttcttaactttctcattattaatgatttttgcttttacatggcattcaaccggaaaaggcatattttgagctttctcaaa |
465. | tgtcgtattaatactgccttcaccagtattgctagcatttggatcttgagtttgtgcgtttgctgctacaggtgctgctggttgcgctgctgctggagcattcgctggctgtgtttgatttgccggtgttgcattattattaggtgttgcttggttatttccttgacctgcttggtttgccggtgttgcttgatttccaggttgtgcttgtgcagcgttattcggatcagcttgattaccttgtccagctggttgtgtatttggttgtgctgctcctcctgctggattagcctgtccaccttggtttgctggttgtactgctggttgtccttggttggcaggtgcagctggctgtgctgtaggattagcttgagcaccagcatttgcgttaggctgtgtattggcatcagctggttgtgctggttgattttgtgcaggctgattttgctctgctgcagacgctgttgtcgggttagtagatataaaagtaacagtggcaat |
466. | atccaacgtttcaggaataaatgttttcaaaccactttgaaatggatcgcggtgttgtgcttgatatactttgtagcgataacgtttacctacacaatcataacgacaatgaaaatcttcatcgactgtaactacattgttgacataaatatcatcagg |
467. | cggtataaaggtaaagcaaaatgcatcagcttgcttagaatgattgtcctttttttgataatagcgttccattgcaatgacggcagasggatggtttgcaaacaaatgatttgtatattcactttc |
468. | atgcaagagtaccaaaaatcgttaaatacgcttaaaaagcctataaatgttccgtatgagcaagaaactgaaaaagtaggtggtttatttagcaaagaaatacaagaaactggaaatgttgtaataagccaaaaagatttcaatgaatttcagaaacagataaaagctgctcaagatatttcggaagattacgagtatataaagtctggtagagccttagatgataaagataaggaaatacgagagaaagatgatttattaaataaagcagttgagcgtattgaaaacgcagacgataattttaaccaactttacgaaaatgcaaagccacttaaagagaatatagaaatagcgttaaagcttttaaaaatcttactaaaagagttagaacgagttttaggaagaaatacctttgcggaaagagttaataagttaacagaagatgaaccaaaactaaatggtttagcaggaaacttagataaaaaaatgaatccagaattatattcagaacaggaacagcaacaagaacaacaaaagaatcaaaaacgagatagaggtatgcactta |
469. | atgctaactactttcgctgttgtactcattttcttcttacttccatcttcatttttattg |
470. | ttgagcatctgcatcattattatcattcatgcgatcatttttgttcacattattaaaaatggcattcaaaataacaat |
471. | ttgcctataccaagtactagaagtgcaccaataattccagcaatcaatgcaacgatgactgttttaaaccatggaaatttaggtcttctgtatctaggtgtttggctatggtttgttgtagaa |
472. | atgcttttgagttacttcataatactcatcagttttttgtgtatccttttgacttttatttatttctttccacttaccagtatgactttctttttttacagttattttcggtttgtt |
473. | atgacttgtgaaaaactggaaaatttcttgaccagtagcaaagccggcaccaacgacaacaccaacaaaggcaaatgccacaataatggactcttt |
474. | ttgattgtcattagtaacgttattggcattattttgatttttatctgttttgtctgcactatcatcttgttgatcattttcttcggtttctgtctttttatgcgtagatttattttcttgttcttggttattact |
475. | atgtgcagaaattgcccagcattcaccagttgtttcattagggatatcatagttaaatgcttt |
476. | gtggtatacaacgcaacgtatatgcatcttgtacacgtatttctgattgtcgcgtcgttaatgttgatccttctaaccaatcacgcatacgcgctgccacat |
477. | gtgacaaatatcacactaaacagtgcatttgcagatgctacgataagcgtatttttataccaagtcaggtat |
478. | ttgtgcagtagtagcttggttactattcttaagcttttgttctgcatctctcaactgtttaagtttttgatacgcatcttgtttacgttgatttgtacgtttatattgattttcagcttttttaagttctgtattcga |
479. | ttgccttcttgtttatattgttcaacaagtgctttatgcttagcggactgcttctgtactgcgtcacttgctctttttagttgtgcagtagtagcttggttactattcttaagcttttgttctgcatctctcaactgtttaagtttt |
480. | caiippiegpnpspkatidpikpkalpcfflviflatttiisegnaadptpctnlpkikikk |
481. | ashfsfhligykqiilnifrstvasillffcllfmiyfrtvkfflnfliindfcfymafnrkrnilsflk |
482. | crintaftsiasiwilslcvccyrccwlrccwsirwlclicrcciiircclvisltclvcrcclisrlclcswlrislitlsswlciwlccsscwislstlvcwlycwlslvgrcswlccrislstsicvrlcigiswlcwlilcrlillccrrccrvsryksnsgn |
483. | iqrfrnkcfgttlkwiavlcliyfvaitftytiittmkividcnyivdiniir |
484. | rykgkakcisllrmivlfliiafhcndgrrmvckqmiciftf |
485. | mqeyqkslntlkkpinvpyeqetekvgglfskeiqetgnvvisqkdfnefqkqikaaqdisedyeyiksgralddkdkeirekddllnkaverienaddnfnqlyenakplkenieialkllkillkelervlgrntfaervnkltedepklnglagnldkkmnpelysegegggeggknqkrdrgmhl |
486. | mlttfavvliffllpssfll |
487. | lsiciiiiihaiifvhikngignnn |
488 | lpipstrsapiipainatmtvlnhgnlgllylgvwlwfvve |
489. | mllsyfiilisflcilltfiyffpltsmtfffysyfrfv |
490. | mtceklenfltsskagtndntnkgkchnnglf |
491. | livisnviaiilificfwtiilliiffgfclfmrrfiflflvit |
492. | mcrncpaftscfirdiivkcf |
493. | vvynatymhlvhvflivaslmlilltnhayalph |
494. | vtgitlnsafadatisvflyqvry |
495. | lcssslvtilkllfcisqlfkflirilftlictfilifsffkfcir |
496. | lpsclycstsalcladcfctaslalfscavvawllflsfcsaslnclsf |
497. | caagtgctgaaaatgcttcagaacatcctcttgctgatgctattgttacttatgctaaagataaaggtcttaatttacttgataatgacacttttaaatcaattccgggacatggtattaaagctacgattcatcaacaacaaatccttgtgggcaatcgaaaat |
498. | aagaggcttgttatgcagcaacacctgcaattcaacttgccaaagattatcttgctcaacgccctaacgaaaaggttcttgtcattgctagtgacacagctcgttatggtattcattctggtggtgagcctactcaaggtgccggtgcagttgcaa |
499. | ctgcgcctacgccagtttcagctattatgcacgctggtattgttaatgctggtggcgttattcttacacgcttttctccggtatttaatgacgaaa |
500. | cgtttacgatatacttcatacatcattaaacttgcagccacagacgcgttcaagctattgacatgtccaaccattggaatcttaata |
501. | tcaagcgtttttgctatacgacttactatcactttttctcgattttcaaatgttggatgcaaaaaacatatcaagggagccataataatgaagaaagaaataatagaatggattgtagccataatcgttgcaattgttatcgtcacacttgtgcaaaagtttttatttgcttcttatacagtcaaaggagcatctaatgtcatttatcac |
502. | agatctgtaccacatattgtcgtcttaactatgcgaataatagcgtcagtactgctcgtaatagttggcttctctttatccgtaagttgtgca |
503. | actgccaataatatcatcagcttcataattacgcttaccaacatttacaaaaccaaactgatgggatatttctttaacataatcgaattgaggaataagtccatcaggaggtgctgggcgattttgtttatagccatcatacatttcatttctgaatgtttcttgccccatatcccaacaaactgctacgtgagtaggttcgatttccttgatagcgctaaaaatatgtcttacaaaaccttgaataccatttgtaggaattcctttagaattgtacataaattgattgtg |
504. | ttcttttgtagattgactcaactcaactggctcaaatacttgtccgttagaatgctttacatgtattttatgattttcagtataatgaatcatattgtaagtaccatttgt |
505. | atttttatatctacatgcgggtgtagtacaacatcagcttggaaggctgaggttttgccattaagggttcgattcccatcacccgctccattt |
506. | ctaaagaatatattgaggattgtatttattgctggtttgacagttttcttctctggtcctggccaaacttattcaaacgcagcatttattgatgaatatattcaaacatttggatggagccgtacagaagtt |
507. | aggaattccaatcaaatgtaccaaacatttacagcggatattgtacttatatttatgattattgtacttggaggacttgtagttcaagttccaatgccaattttagcaggtattatggttatggtttctgagacaatctactgtttgcacctgat |
508. | aatcaacgactcgaggaaacaatttcctctccccatcacagctcagcctta |
509. | atgaaacaatttttaaacatcactcaacgtaaatttatcgaatggttgattatcttatccatttttatagttagcattcctaataaatggacattaatgatatctatcgctttatctttattacttcttaaaagaggggcgctaggtgtcgttcaattaatcatactttatatgctcagatcgcaaatatacaccccatatgatacacaagagatggcgcattacatagtaagtatgaaatatatcttgatttatgtaattggagtattttttctatttaaatatgtaaaacattggataagaaatgaaatgatattaagatttatcaagtctactatgattcttatgctactttatatcataatgagtttagtcgtatctaatgatccgatagaatctattcttaaattgcttaacttctttataccgctaattttgattgttatgtatgttagtttaataaaaaagataaagaatctcattaactggattaatcaatttatcacgctagtgattgcctttacttttttatttatagttatagcgccaaaatcatatttaattgatgaggaatcacttagaagtgttttcaaggatgcacattcattcgcagttattcttgctatgggtctagttctatatatggtaacaataatcaaacaacaagattatgatgtattcaatttattattattaaatattggaatgatagagctctatttatcaaattctcgtcatattttcatatctgttattttatgtctaatgcttctattaccgttatctcacataaaaaagagaattaaacatcccataattggtgctatgatactaatggcaattgctataataaatcaaccatatatttatcatctttttattaaactaatcttaaaagggaagaatagccaagaggtctttatgccgagtgatatgaatattaaagctattgattatgcgctaactgagcatccttttttaggaagcggttttggtataccaatgataaaagcgagttcagaaatacaatactttaatgtagcaacgagtaatatcatcttcggtatgattatctttactggaataataggacttactttatgtacgatatacatgcttcatatggtacttttagttacttttccaatgagtattactattttattatttttaatcactatctttgttaatatggattatattattttatttgattccgtggggctaggtatattgtgttatatattttggggaatatatttaaaagaaggtatgtatcaatacaacaacggacaatgg |
510. | atgacaaatcaaaaaactgtgggtctagtcgtcgctccaggtgttactgaacgccttgcagaaaatctcatacaagaaatgcctaaaatgttatctacacattatgatcatcagcaagaatggatttttgatttagttacggatccgcttactggttttgctgaatctgtagatgaaatttttgggaaagtagccgattatcacgataagagacaatgggattatgtgatagcaattacagatttaccgatgtttgcggacaagcaagtgatggcattagatattaatatggaaaatggtgcagctatattctcatatccggcatttggctggcgtccagttaaaaaacgtttcaagcatgcgatttataatattattcaagaattaaatgaagctgaacaagaaagtcgtaattatgataataataagcaaatagaaaattcagtaaaaaaacaatttccgctctctaaaatagataaagaaacaatatatatgaaagaaacagactcttatcacttaagatatttatcaagttcacgttctagaggcatgtttcgccttgttagtggaatgacctttgcgaataatccattaaatatgatggcaagtttaagtaatatagtagctattgcatttactacaggtgcatttggacttgtatttacaacgatgtggcaaatggcttataacttttcaatgtggcgcttatttggaatttcaattattgcgattattggaatgctaatatggataatgatgtcacatgatttatgggagccagttaataaaagcaaccataagcatattacttggttatacaatcttacaacaataatgacattgatttttgccattataatttattatattattctttatttactattcttaattgctgaaatcgtattattgccatcaggattcttaggtcagcaagttggattgaaaggtcctgcaggcattgatttgtatttaagtattccatggtttgcagcttcaatttctacagttgcaggtgcaataggtgctggtttacttaatgatgaactcattaaagaaagcacatatggatatcgtcagcgtgtaagatacgaagaacaacgtcga |
511. | atgaaattctgccctcattgtggaaatccgataaaaaaggaacagtcattttgtaataaatgtggaaaacatttaaagacatcgacacaaagaaaaagtgaaaatcaaattgaacatatgcgtgaacagcaatcgtatatttctcgtgaggaaagacaacatcatgattcaacattttataaagaacaaaaacatactggttggctaattgtattatcaattatatttgtcttgttgatagcagcgctattgtatggtgcgtactatgcttacaatcattatattagtgatgagcaaagtcaccaaacaacagagtctcagcaatcaaatgaaagtgatcaaaatagggaccaatccactggtccaagcattgatgtttttagtgatgactttgatcaaggttatatgaagtcagcttcaacaagtggatatagaggtgtttataatggaatgacacgtgaagaagttgaagataaatttggaacatccaatggttctgtgaaagtttgaagtggagttacgaaaacatatggtgatttagctgtagcctacgatgataatgaagttgttagcgtaggtgtagcacctaatcatatttcagaagatcaatttttaagtatgtataatgaaccggatgatagaaattcaagccaactcatttatgatagtaacaaagataatgacttctctgtgttagctaatgttaaaaatggagatgttactgtcattgaaaatgtaaatcaaatt |
512. | atgttattgtttatcatagaaatcataatcatgattctagcgatattattaggattaagaactgctggtgcactgggatgtggcatctttgctatagtagcgcagcttatcatgatatttggattccagttacctccaggttcagcaccagtgacggcagtgttaatcatattatctattggtatagcaggtggtacgttacaagccactggtggtattgactatttagtatacattgcatcacgtgtgattgaacgctttccaaaatcaattatatttatagcgccaatgattgtctttgtctttgtttttggaattggtactgcaaatatagctctttcacttgaacctatcatagcgaaaactgcacaaaaagcacgaattcagcctaaacgcgcattaactgcttcggtacttacagccaatttagccttactttgtagcccggcagcttctgctacagcttatattatttctgtattagcagggtatgaaatatcgatgggcaagtatttaagtattgttttacctacagctttaattagtatgttaatgcttagtacattttgtacatttgtaggacgaaaagaacacgtgcgtgatgagtcagaacgtttagttcagatgccagaagtcgaaatcaaaaatgacttttcattaaaagtaaaaataggtgttatctcattcctattatgtgtcatgggtattttaacgtttggcatatttcctaatctcatgccgcaattcaatgtgaatggagatgtagttaaagttgagatgactgaaattgttcagttctttatgtatctcagcgctacaatcaatttattattaataaaaatcaatacttctgatattctgtcatcgaatattacacaatctgcaatgggagcactttttgcagttcttggcccaggttggttaggtgcaacaatatttaatgctccacataacttaaaaatattgaaaaatgatattgggtcaattattagtgaagtaccttggcttgttatcatacttgtttctgtagttgcaatgattgtcatttctcaaacagctacagcatcaattatggtgccgatagttatgagtttaggtatacctcccatctattttgttgcgatggtacaaacattaaatgtgaatttcgttattccagctcaaccgacactattatttgctgtagaactagatgaaacaggtagaacaagacctacgagctttatgataccaggattttttgttataacagtatccgtcattacaggatttgttattaaaaccattttaggatat |
513. | atgggaagtttttttaatcggatgactcgaaaagagaatcctactatttatcaaaataaagatgggcatcttaagcgcacgttacgtgtacgtgactttcttgcactaggtgttggtacaattgtctctacatctatcttcactttaccaggtgttgtcgcggctgagcatgccggacctgctgtggcattatcattcttattagctgccattgttgcaggtcttgtagcctttacttatgcagaaatggcatctacaatgccttttgctggatcagcttattcatggattaatgtactttttggtgaattattcggatgggttgccggttgggcgcttttagcagaatactttattgctgttgctttcgttgcttcaggcttttctgctaacttaagaggtcttattgcaccattaggcatttctttacctaaatcattatctaatccatttggaagtaacggtggtgtcattgatatcattgctgctgtagtgattattttaactgcattactattatcacgcggaatgaacgaagccgctcgtatggaaaatgtattggttatattaaaggtgttagccatcattttatttgtgattgttgggctaactgcgattaatttcagtaactatataccatttattccagaacataaggttactgaaactggcgactttggaggttggcaaggtatttatgctggagtttcaatgattttcttagcttatattggttttgactctattgctgctaattcagctgaagcgattaatccacagaagacaatgcctagaggaattttagggtcactcatagtagcaattgtattgtttgtggccgtagcacttgttcttgttggcatgttccactactctcaatacgctgataatgcagagccagtaggttgggcattacgagaaagtggtcatggtattattgctgcaattgttcaagcaatttctgtcatcggtatgttcactgcattaatcggtatgatgcttgcaggttcacgtctattatattcatttggacgagatggtttactcccttcttggttaagtcaattgaatcacaaacatttacctaatcgagcacttgtcatacttacaatcattggcgtagttatcggatcaatgttcccgtttgctttcttagcacaattgatttccgcaggtacccttgttgcattcatgtttgtgtcactagcaatgtatcgattaagaaaacgtgaagggaaagatttacctaagccagagtttaaattacctttatatcctattttgcctgcaattacatttatattagtattgctagtattttggggattaagttttgaagctaagttgtatacactgatatggtttattgtaggtataattatttatttaatttatggaattagacattccaaaaagaatgatgaagaagcgtatcaagtacctagagaa |
514. | atgacaaagaaaaaacgtttatcgcctagtgagtggttgcttaaacaatctaaaagacataaaaggaaaaatacactttacacggcaattgtacttttagtagcgttagttctactcatatttgctgttaaatcaatacaagtagaacctgtaaaaagtgatacgagagacaaagatagcattcgtatcacctatttaggtaacgtcactttaaataaacatattcgacaaactaacttgaatgatgtttttaaaggtattcaagatactttagatcatagtgatttttcaacaggttcattaatagtaaatgatttttcaagaaatcaaaaagataacataaataaaaatattgaaaatatcatgtttctacgcaagcataatgttaaaagtgttaacttaatcaacgaatctatggataatattcaagcgacagcaatgatgagaaaaatagattcccaagcaggttataattttttaacaggtaatggttcaaatccaattaatagtaaaactgtacaacaagacattaaaggtaaaaaaatagctaatgtttcatttaccgatatcgaatctaaactatactactctttaaaaaacacgacgtcaattagtttagatccagctatattttatcctttaataaaaaaattaaaggaaaataatgattacgtcgtagtcaatgtagattgggggatacctaatgaacgaaatgtgactacacgtcaaaaagaatatgcacatgcgttagcgaatgctggtgcagatgtcattattggtcataatacagttattcaaaaagttgaaaattataagcgaacgcctattttttatagtttaggtaacacacgtctgataacttcttatcaaaaaaatcagaaaggaatgattgtacaacaagactggaaaggttcgcataatcagttccatatcacaccaattcaatcaaaagatggaaaaatctctaaagataatatgaataaaatggatcatattcgattcaaaaataacattaaagataaatcaattgatttaaaatctgatcaaaatggaggttatacttttgaatat |
515. | atgattgaacatttaggaattaatacaccttattttgggatattagtatcattaataccatttgtcatagcgacttatttttataaaaaaacgaatggtttctttttactagcacctttattcgtaagtatggttgcaggtattgcttttttgaaattgacaggaattagttatgagaattataaaatcggtggcgacattattaatttcttcctagaaccagctacaatatgctttgcgattcctttatatcgcaagcgcgaagtattaaaaaaatattggttacaaatatttggtggtatagctgttggtacaattattgccttgttattaatttatcttgttgcaataacattccaatttggcaatcaaattatagcatctatgctacctcaagctgcaacgacagcaattgcattacctgtatctgacggtatcggtggtgtcaaagaattaacctcactcgcagttattttaaatgcagttgtcatttctgctttaggtgctaaaatagttaaattatttaaaatatctaaccctattgccagaggacttgcactagggacaagtggacacactttaggtgtcgcggcagctaaagaattgggtgagactgaagaatcaatgggaagtattgcagttgtcatcgttggcgttattgttgtagcagtagttcctatacttgctccaatcttatta |
516. | atgaaaagaacagataaatatagagattcatacaaatatgatgaccaatatcaaaatcatcgtaaacgttcagaagaagatatgtatcgacaacatcaagagtcccaacagagagcaaattcaaatcgtgcaacacaaagtgaaaatgatagagagtatgaaaatcatcctgaacgttattacaatggaagagactatcgacgtgagcagcaattggaagaagaaaatgaaaaatcaagcaaaactaaaaaatggctgattgcaatcatagttattttactcattattgtagctatctttatcacgcgtgcaattatcaatcataataatgataaagtaagtaatgaccctaacgtttcacaaaactataaaaaggaagttgaaaatcaaaacgacgacattaatcgacaagttgattcagccaaaagcgatataaaaaataaaaaggacacccaatcccaaattgataaactacaaaatcaaattgatcaattaaaacaaaatgaagaaactaatgcggattctaaattcacaaaattttatcaaaaccaaatcgacaaactgaaaaatgcaaataacgctcaacttaataacgaaaatcaaagtaaagttaacaacatgcttgaagacatcaatacaaaatttgatagtattaaagctaaactagaaaatatcttgaatggatcaaattcaggaaac |
517. | atgaacatgaaaaagggtgtttctcagcttacgttacagacattgagtttggtcgcaggctttatggcatggagtatcatttctccattaatgccatttatttcacaagatgttgatatttctccaggacaaatatctgtcattttagctattcctgttattttaggttctgtactacgtgtaccatttgggtacttaactaacattgtaggagcgaaatgggtgtttttctggagttttattgtactattacttccaatttttcttttaggtcaagctcaatcacccggtatgctaatgttatcaggattctttctaggaattggtggcgcaattttttcagtaggtgttacttcagtacctaaatacttttcaaaagacaaagttggtttagcaaatggtatatatggtgtaggtaatattggtactgcagtttcatcattttgtgccccagtgttagcaggtgcaattggctggcaaaatacagttcgtagttatttaattattctaagtatatttgcaattttaatgttttttttaggagataaaaatgagccgaaagtgaagattcctttgatggctcaagtcaaagacctatctaagaattataagttgtattatttaagtttgtggtattttattacttttggagcttttgtggcttttgggatttttttaccgaactttctagttgatcattttagtattgataaagtggatgcaggtattcgttcaggtatatttatagcactagcgacgttcttaagaccggttggtggtgttataggtgataaatttaatgcagtacaagcgcttatcatcgacttcgtgataatgattattggtgcgcttatattaagcttatctagtcatattgttctgtttacgataggctgtttagcaattagtatctgtgcaggtataggtaatggtttaatatttaaattagcaccttcatacttttctaaagaagcaggttcagcgaatggtattgtatccatgatgggaggactaggcggtttcttcccaccactggtgattacttttgtaacgagtatcactggttcaagtcatctcgctttcttcttcttggctatatttggtgtaattgctcttattacaatgattcatttaaataaaaaagagaaagctattcgtata |
518. | atgaaaaataaaaaaggattaggcataggtcttatcacaattatgattatcgtttgtattgtactagtaatcatgatgttcgtgggtggtaagaaagaatcatactacggtattatgaaagatagcacgactattgataaaatgataaatactaaaaatgaaaaaattgaaaaaaacgtagaattacctaaagatgctaatgtatcagttaaaaaagaagattttgtgatgctctttaaagatgaaaaaactggaaaaattactaaagttaagaaagttaatcacgatgacgtacctcatggtttaatgtcaaaaatccatgatatgggtaatatgaaacacggaatg |
519. | atggctatgtcattactcgtgagtcttgtggtttatatgatgacactcacatctgatatattagaagatattctatcatttaaattagaagtgataatgcaatttccgtatatattaagctctatttcactaatcattttgtttatacttttcattttaaaagatatggaaaaaatatggtactggctcatttcaatagttatgattgctgtgataagtatgtctggacacgtgtggtcacaacaagtgccattatggtcaattatcataagaacaattcatcttatagggctaacgttatggttaggttcactcgtttatctcatttgttatgctattaaagtgaaaattaatcagttgacgagtgtaagacgtatgcttttaaaagttaatatcattgctgtgattatgctcgtttttacagggattttaatggctattgatgaaacgaatactttaacactttggaataatgtgagcgcttggtctatttatcttgtcataaaaatggcaggaattattgctatgatgctattaggtttctatcaaacgatgcgtgctttgagacaacgacaacaggtccatcgttttgcactgatgactgaattgttaattggtatgatattaattttgcaggtatca |
520. | atgaaaaactctagattttctgggttccaatgggctatgatggtctttgtatttttcgttatcacaatggcattgtccgtgatactcagagattttcaagcgactatcggagtgaaacgttttgtctttagtattaaagatttagctcctttcatagctgcaattgtgtgcatattagtatttaagcacagaaaagaacaattagcaggattgaaattttctatcagtttaaaagtgattgagcgtctacttttagcactcattctaccacttatcattttaatgattggcttgtttagctttaatacttatgctgatagtttcatcctattacaaacttcagatttatcagtatcattattaactatattaattggtcatattttaatggcttttgtagtggagtttggtttccgttcttacttacaaaatattcttgaaacaagaatgaacacattttttgcgagtattgtcgttggtcttatttattcagtatttacagctaacacgacatatggtgtagaatacgccggataccatttcttatatacattcatgttttcaatgattattggtgaattaattagagctactaatggtcgtacaatttatattgcaactgcttttcacgcatccatgacttttgctctcgtctttttatttagtgaagaaacaggcgaccttttctcaatgaaagtcatcgcactttctacaacaattgtgggtgtttcatttattattattagtctaatcattcgtgctattgtttataaaacgacgaaacaaagtttagacgaagttgatcctaataattatttatctcatattcaagatgaagaaccaagtcaagaagacgcctcttcaacttcaaatcatgatgtatcatctaaagatgaaacaaagcaacaagatattgataatgacaaacatcaatcaaagaaacctaataagagtgacgatgcacttactacttctaattataaagaagacgcctcttcagttaataaagaaacggatacaactcacaatgataacattaaagatcattcaacttataccgaagatagacactcatctgttgtcaacgatgttaaagatgaaattcacgaagttgaagatcataaagccgacacagataaatcacat |
521. | atggaaaataatgagttgcaaaggggattgaatgcacgtcagatgcagatgattgctcttggtggaacaattggtgttggtctttttatgggagcaacaagcacaattaagtggacaggtccatcagttattcttgcatatttaattgctggtatttttttatttttaatcatgagagccatgggtgaaatgatatatattaatccaaccactggttcttttgcgacgtttgctagtgactatattcatccagcagctggctacatgactgcttggagcaatgtatttcaatgggttgtcgtcggcatgagtgaagtgattgcagtaggagaatatatgaactactggttcccaagccttcctaattggataccaggagtgatagcagttctctttttgatggctgctaacctagtttcagtaaaagcgtttggagagtttgaattttggtttgccttaattaaagttgtaactattgtattaatgattattgcaggattaggattaattttatttggtataggcaatggagggaatccaatagggatttctaacttatggtcacatggtggatttatgccaaatggattcattggatttttctttgctttatctattgtgattggatcataccaaggtgttgaattgattggcatctcagcaggtgaaaccaaaaatcctcaaacaaatattgtaaaggcagtcaacggagtgatatggagaattttaattttctatattggtgcaatttttgtcattgtatcagtatatccttggaaccaattaggtagtattggtagtccttttgttgcaacgtttgctaaagtgggcattacgtttgctgctggtttaataaactttgtagtcttaacagcagcattgtctggttgtaattcaggtatttttagtgcaagtcgaatgatttatactttggcaaaaaaaggacaaatgcctaaagtatttactaaagtaatgaaaaatggcgtacctttctacactgtatttgcagtatctatgggaatattaattggtgctttattaaatgttatacttccattaattattgatggagctgatagtatctttgtatatgtatatagtgcctctattttaccgggaatgataccttggtttatgattttatttagtcatctaagatttagaaggttacatcctgaaaaggttcacaatcatccttttaaaatgccgggaggggcaattgccaattatttaactatcatgtttttactcctagtattagtcggtatgttacttaacaaagaaactgtagtatcggttgttattggtatcgtgtttttaacagctgtgacactttattatcttattagatatcacaaaaaggaacgacaaata |
522. | gtgaaaagacttaagaattttattctcggcttactcattgtggctatagttggcttcctattatttatgtatatagatgatagtcgcattcaaagttatcaagactacttcttacaatttaattggttccaaccactattgattgggcttgcaggattacttatattaatcggacttatattagtacttagtatttttaaacctacgcatcgcaaacctggactttataaaaactttgatgatggacatatttacgtatcacgtaaagctgttgaaaaaacaatttacgatacaatcgctaaatatgatcaagttagacaaccaaatgttgtaagtaagctttataacaaaaagaataaatcatttattgacatcaaagcagatttcttcgtaccaaaccatgttcaagttaagagtttaacagagagtatccgtgctgatatcaaaagtaatgttgaacactttactgaaattcctgttagaaaattagaagttaacgtacgtgatcagaaaacatctggtccacgtgtattg |
523. | ttgcaagattttgataacttaattcctggctggtttaaaacatttgttcaagtcgggaatgacttaatttggtctcaatatcttattggattattattaacagcaggttttttctttacaattagttctaaatttattcaactcagaatgttaccagagatgtttagagcattaactgaaaagccagaaactttaagtagtggtgagaagggtatttgaccatttcaagcttttgcgattagtgctgggtcaagagtaggaactggaaatattgccggtgttgcaactgctattgttcttggtggccccggtgcagtcttctggatgtggattattgcttttattggtgcagctagtgcatttatggaagcaacgcttgctcaagtttataaggtacatgacaaagaaggtggattccgtggcggaccagcctattacataacaaaagggctaaaccaaaaatggcttggaattgtatttgctgttttaattacagttacatttgcttttgtatttaatactgttcaagcgaatacaattgctgaatcattaaatacacaatacaatattagcccggtaattactggaatagtacttgcagttattacaggtattatcatctttggtggtgttcgtagcatagctacactatcttcacttattgtgcctattatggctattgtttatataggtatggttttaatcattttattactcaatatagatcaaattgtacctatgattggcactattattaaaagtgcattcggagttcagcaggttactggtggtgctgtaggagctgctattcttcaaggtattaaacgtggtttattctcaaacgaagctggtatgggatctgcacctaatgctgctgctacatctgctgtgccccatcccgttaaacaaggtttaattcaatcattaggtgtattctttgacactatgcttgtttgtacagctacagcaattatgattttattatattctggtttgcaatttggtgatagcgcgcctcaaggtgtagcagttacgcaatcagcgttgaacgaacatttaggttcagcaggaggtattttcttaactgtagcagttaccttatttgcattttcatctgttgtaggtaactattactatggacaatccaatattgaatttttatctaacaataagatgatattatttatttttagatgttttgtagtacttttagtatttgtaggtgctgttgctaaaacagaaacagtttggagtactgccgatttatttatgggtcttatggcaatagtaaatatcatatcaattataggtttgtcgaatattgcgtttgcagtgatgaaagattatcaaagacagcgtaaagaaggtaagagacctgtgtttaaacccgaaaacttagaaataaatttatttggcattgagacttggggacaacatgcaaaaatgccaaaaaaa |
524. | ttgaaaaaagaaattttagagtggattgttgccatagccgttgccattgcacttattgccataatcactaaatttgtcggaaaatcatattctattaaaggtgattcaatggatcctacattaaaagatggggagcgtgtagtggtaaatattattggctataaattaggtggcgttgaaaaaggaaatgtcattgtatttcatgctaataaaaaagatgattatgttaaaagagttattggaactccaggagatagtgttgaatataaaaatgatacactctatgttaatggtaaaaagcaatcagaaccatacttgaactataatgaaaaacgtaagcaaactgagtatatcacaggtagtttcaaaacaaaaaatttaccaaatgctaatcctcaatctaatgttattcctaaaggtaaatatttagttttgggggataaccgtgaggtaagtaaagatagtcgttcattcggtttaattgacaaagaccaaattgttggaaaggtatcgctcagatattggcctttcagtgaatttaaatctaactttaatccaaataacactaaaaat |
525. | atgttcaataaggtttggtttagaacaggaatattttttattatgctgttcatactcatcaaactatttatggaagtgcatgaagtatttgctccaatagctactatcattggttcagtcttccttccatttttaattagtggatttctcttttacatatgtttaccttttcaaaacatattagaaaagtggggctttccacgttgggctagtataacaacaatattcataggattaatagctatcatcgctattgtggtatcatttatagcacctatcattatttccaatattaataacttaattaaacaaacaccatcattacaaaaagaagccgaacaattaattaatttctcgttaagacaaatggataaattaccagatgatgtcacacatcgtattaataaagcggttaaatccatgggagatggcgcaacgtctattttatctaattcagtgtcatatattacgtctttcatctcaactgtatttttattaataatggtgcctttcttcctgatatatatgctaaaagatcatgaaaaatttatcccagcaatcggtaaatttttcaaaggagaacgtaaagtttttgttgtagatttattaaaagacttaaacttcactttaaaatcatatattcaaggtcaagtgacagttagtatcatcttaggtattattttatatataggttatacgattataggattaccatatacacctttattagtattattcgccggcgtagctaacttaataccatttttaggtccatggttatcttttgcaccggcagcgatactaggtattattgatggcccttcaacttttatttgggtatgtgtcgtaacattaatcgcacaacaacttgaaggtaacgtgataactcctaacgtaatgggtaaatcattaagcattcatccattaactattattgttgtcatacttgcagctggagatttgggtggtttcacactcattcttgttgcagttccattatacgctgtaatcaaaacattagtgagcaacatttttaaatatcgtcaacgtattgtcgataaagcaaatagtaatgttaaagat |
526. | atgaatacaatcgtaaaacatacagtaggttttattgcttctatcgtactaacgcttttagcagtttttgtaactctatacactaatatgacattccatgctaaggtaactatcatctttggttttgctttcattcaagctgcccttcaattattaatgttcatgcatttaactgaaggtaaagatggacgtttacaatcgttcaaagttatctttgcaattatcattactttagtaactgttatcggaacatactgggtaatgcaaggtggacactcttctcactta |
527. | atgtcttttcttaggaaacacaccgaaattatatttagttatatcatcggtatcgtttcactttttacaggtctcattatttttattaacttacctttaatcaaacaatttaaaggtgacaaaaaggttgatacgcatgtgcataacgtatgggaattcctaaatgccttttttgccgagattataaaagtgatgagtaaatttattggtggctttccaattacaagtgccatagtaatcatcgtatttggtattctagtgatgctgttaggtcacactttatttagaactattaaatacgattatgacatttcaattttctttttagttattggcattatgtactttatcattacattattgctaatgacacaagtgtatggcttttttgctatcgtctttattattccttttacagttcatattggttacatagtttataaagatgagttgaaccaagacaatcgaaagaaccattatatgtggattattgtaacttatggaatgagttatcttattacccaaatttcgctatatggacgtattgacgcaaatgaaattgaatcaattgatattttaagtgtaaatacattcttcattattatgtggttattaggtcagatggctatatggaatttcttattcctaagacgttcattaccactcactaaagaagaattaggcgaagaggaacctgaactttcaagaactaataaaggcaatgtatctaatcaaactaaagttcacttaaaacaactacaaaataagacaaccgagtatgcacgtaagactagaagaagtgttgatttagataaaattagagccaaaagggacaaatttaagcaaaaaattaacagcatagtagatatacaagaggacgatattccaaattggatgaaaaaacctaaatgggttaaacctatgtatgttcaattgttttgtggtgtaattattctgttttttgcttttctagaatttaataatagaaacgcattattcttaactggtgaatgggagttatcacaaacgcaatatgtagttgagtgggtaacattattattgctacttttcattattattatttatattgcaactacattaacttattatttaagggataaatattattatttacaactctttatgggcagtattttattctttaaatttcttacagaatttatcaatattatggtacatggattattattatcaattttcattacgccaatcttattattaatgcttattgcaatgattgttgcttattctttacagttgagagaaaaa |
528. | atgttaggagagcaatatacacaaattaagcgtccagcaaatcggctaactgaaaaaatattaggttggtttagttgggtattcttactcatattaactattgtttcaatgtttattgcgctcgtatcttttagtaatgatacgtcaattgccaatttagaaaacacacttaataataatgaactcgtacaacaaattttagccaataatgatttaagtacaactcaatttgtgatttggttacaaaatggagtttgggcaattattgtttattttattgtttgtttgctcatctcgtttttagcgttaatttctatgaatataagaattttgtctggtttactttttttaatagctgctatagtcacaattccgcttgtattgttgattgtaactctaatcattcctatcttattctttatcattgcaatgatgatgtttgctagaagagagtagaatagaaacagtgcatcttattataatgaatatgatcaaccatactatgatgagagaggtttttatgaaccagagtcaagaaatgaacatggatataatgatgatgtgtatgaacctatgcatactaaaaaggaagatagaaatacaagacgtcaattcaatagaaatgctcagcaacaagattcctataatggtataactgataatcaacccgatgaagatacatcttccgatcaactttattcagacgaatatgtagataatgaagataaatattctcaatttccaaaaagagcagttgaaagtgaatatgcatctcaacaaactgaagatgaaccaacagtcatgtcaagacaagctaagtacaataaaaaatctaaaaatacggattttgaagatgcgcaacaggaacatatggaaggtaatcaatttgatgacgtaggagttgttgaaccacaaattgatcctaaagaactaaaagcgcaaagaaaaagagaaaaagcagaaatacgtgctaagaaaaaagaaaagagaaaagcatataataaacgtatgaaagaacgaagaaaaaaccagccaagtgctgttaaccaacgacgtatgaattatgaagaacgtcgacaaatgattaataatgaacaagaagatacagataataacttaaatcaacaggaagattcaaaaaaagaaaat |
529. | atggaagagaataaaaatcaacctaataatgagaatatgtcgaataaagacgataatacaatccatttgaatgatagtcaaagtaatgaagacttagagctttttagacggaataaaaacgctcgccaacgcagaagacgtcgcatagataaccaaagtaaagaaaaagatgctacgtctacacaatcacagttagaaactaaaccaatggataaatttattgataatcacaagtcgcataatcaagataaagaaataaaaagtgatttaattgaggataatgttaatgatgaagatgacaatcaaaaatataataatgataaattaaatgatcgtagtgttcaacaaacaagcgaaacgcgtcaaagtaatgaagacgaagaggaatttctaactgatcatcagagcgaaaaacaaactaaagactctcgtcattctaaaaaacataaattactaagtaaatttacttctaaaaaagaaaaggaaacatttacatcgttcaatagtaatgagaaggtaactcaaattaaaccgcttagtttagaagaaaaaagagccataagacgtaaaaagcaaaaaagaatccaatatacaattatcacactactcattcttatcattgttctcattttactctatatgtttacaccactaagtaaaatatcaaatgtaaatattaaaggtaataacaacgtaagtacgagtaaaataaagaaagaacttaacgttacttcacgttcacgaatgtatacttttagtaaaaataaagcgattaggaacttaaaacagaatcctttaatcaaagaggttgatattcataaacaattaccaaacacgttaactgttaacgtgactgagtaccaaattgttggtttagaaaaaaataaagataaatatgtgccaattatagaagatggtaaagaattaacagaatacaaagatgaagtttcacatgatggacctatcattgatgggttcaaaggagacaaaaaaacacgaattataaaagctttacctgaaatgtcacctaaagtgagaaacttaatagcagaggtgagttacgcaccaactaaaaataaacaaagtcgcataaagatttttaccaaagataatatgcaagtcattggtgacattacaacgattgcagacaaaatgcaatattatcctcaaatgtcacaatcattaagcagagatgattctggcgaacttaagacaaatgggtatattgatttatcggttggagcgtcatttattccttatcaaggttcatcaactgttcaatcgggtactgaacaaaatgtaaccaagtcaacacaagaagaaaatgatgcaaaagaagaacttcaaaatgtgttgaataaaattaataaacaatctaaagaaaataat |
530. | atgaagtgtttgttcaaaatgctatcaatcataataataatgttaagtactttcaccttattcatcagtccgagtacatatgcaaatgaagatgaaaattggactaaaataaaaaatcgaggagaactaagagttggattgtcagctgattatgcacctttagaatttgaaaagacgatacatggtaaaactgaatatgcgggtgtagatatagaattagctaaaaagattgcgaaagataatcatctaaagctaaaaattgtaaacatgcaatttgatagcttattaggtgcacttaagaccggtaaaatcgatattattatctccggtatgacaacaactcccgaacgaaaaaaagaagtggattttacaaaaccttacatgattacaaataatgtgatgatgattaaaaaagatgatgcaaaacgttatcaaaacatcaaagattttgaaggcaaaaaaattgctgcgcaaaaagggacagatcaagaaaaaattgcacaaactgagattgaagatagtaaaatttcttcactcaatagattacctgaagctatattatctttaaaaagtggaaaagtagcaggtgtagttgttgaaaaaccagtaggtgaggcatatttaaaacaaaattcagaactaacattttcaaagattaaatttaatgaagaaaagaaacaaacatgtatagctgttcctaagaactctcctgtacttttagataagctaaatcaaacgattgataatgtaaaagaaaaaaatttaattgatcaatacatgacaaaagcagccgaagatatgcaagatgatggaaattttatttctaaatatggcagttttttcattaaaggaattaaaaatactattttgatttcattagtaggtgtggtattggggtctattttaggctcttttatagctttattaaaaataagtaaaattagaccattacaatggatagcaagtatatacatagaatttttaagaggtactcctatgcttgtgcaagtgtttattgtattttttgggactactgcagctttggggttagatatttcagctttaatttgtggtactattgcgcttgttataaattcttcagcctacattgccgagattattagagctggtattaatgctgtagataaaggacaaactgaagctgctagaagtttaggattgaattatagacagactatgcaatcagtagttatgccacaggcaattaagaaaattttacctgcattaggtaatgaatttgtaaccttgattaaagaatcgtctatagtttccacaattggagtgagtgaaatcatgtttaatgcacaagttgtacaagggatatcttttgatcctttcacaccattgttagttgcagcattactatatttcttacttacatttgcacttacacgtgttatgaattttattgaagggagaatgagtgccagtgat |
531. | atgcaacaagaaacgacatcatggtacaaacaagaatggtttatagttttatcacttttattcatttttccactaggtttatttctcatgtggaaatttagcaagtggccatctattgcaagaacaatcattactgttgcaatttcagttatcgtattagcaagcattacctattatggtaatctacaaatgattgtaccagcaacatcaaattcaaataacgaaactaaagaaactacagagaataatgtaaatgataaagacgagcgaaatcataaaactgcagtagaagaaacaaaaactaattatgactccaccaaagaaaatactaaagaacctggaaaagaaaatgaatctgcaacacgattggagaactctgcgcttgaaaaggcaaagtcatattatgatgattttcacatgtctaaactaggaatttatgatattttaacatctgaatatggagaaaaatttgataaagaagatgcacaatatgctatagatcatctagaggctgattatgaaaagaatgcacttgagaaagcaaaatcatatgccaaagatatgcatatgtctaatgactcaatttacgatcttttggtgtctaactacggtgaaaaatttacagaatcagaagcaaaatatgctattgagcatttggataat |
532. | atgagtcataagatattagtatcagacccaatttctgaggatggtttacaaagtattttaaaacatccagaatttgacgtagatatacaaacagatttatctgaaaatgatttagtaaatatgatttcaacttatgatgctcttatcgtacgaagtcaaacccaagtaacagagcgaattattaatgctgcaacaaatttgaaggtcattgcaagagctggtgtaggtgtggataatattaatatagaagcagcgactttaaaaggtattttagtaattaatgctcctgatggtaatacaatttctgctacagaacattcagtagctatgttgcttgcaatggcacgaaatattcctcaagcacaccaatctttacgtaacaaagaatggaatcgtaaagcatttagaggggttgaactttatggcaaaaccttaggtgttatcggtgctggtaggattggtttgggcgtcgctaaacgtgcgcagagtttcggtatgaaaattttagcgttcgatccttatttaacagaagataaagcgaagtcattagatattcaaattgcaactgttgatgaaattgccgaaaaatccgactttgtaacagttcacacaccattaacacctaaaactcgaggaattgttggttcatctttctttaacaaagctaaacaaaacttacaaatcataaatgttgccagagggggtattatagatgaaactgcacttattgaagcattagataataacttaatagatcgtgcagctattgacgtatttgaacatgaacctcctactgattcccctctcattcaacatgataaaattattgtcacaccacatcttggcgcctctactgtagaagcgcaagagaaggttgcagtctctgtatctgaagaaataattgaaattctaactaaagggaatgttgagcatgctgtgaatgctccaaaaatggatttaagcaaagttgataaaacaactcaaagctttataggtttaagtacaactattggtgagtttgctattcagcttctcgatggtgctccgagtgaaattaaagttaaatatgctggtgacttagcgcaaaatgacactagtttaattacaagaacaattataacgaacatcttgaaagaagatttaggtaatgaagtcaatattattaatgcattagcaatacttaaccaacaaggtgtcacgtataatatagaaaacaaaagaacacattctggctttagtagttacattgagctagaactagttaatgatcaagataaaatcaaaattggcgcaacggtattcgcaggttttggcccaagaatagtacgtattaatgattactcacttgattttaaacctaaccaatatcaattagtaacatgtcataaagataaacctggtatagtaggacaaacaggcaacctattgggaagtcacggaattaatattgcgtcaatgactttaggacgtaacgatgctggtggagatgctttaatgattctttctattgatcaacaagcaagtgaggaagttataaaaattttaaatgaaacaagcggattcaacaaaattattagcactaagttaacaatt |
533. | ttgaagcggaattttattaataatttaatcatattattaattgctattatgttaagtctgttattaaaaatgttacatgtgattttgccatttatgtttggaccaatattagcggcgttattatgtgtaaaagtattaaaattaaaaatacgatggccattttggttgagtcaaattggtttaatactacttggagttcaaattggctctaccttcacacacaaagtgattaaagacataagtaaaaattggctaactatcgtttttgtcactatcctactaattttattagctttgataattgcattcttttttaagaaaattgcacaagtaaatttagaaactgcaattttaagtgttataccaggtgcgctaagccaaatgttagtgatggcagaagaaaataagaaagcaaatatattagttgtgagtttaacacagacatcacgtgtaatatttgttgttattttagtaccacttatttcgtatttttttcaggataaccatcatgaaatgaatcatactacaatggaagtacccacactttctcagactttaaatatatggcaaataatcatcttattctcaatggtgggaatcatctatataggaatgtcaaaaattaacttccccactaaacaattattagcacctataatagttttaattatatggaatatgacaacacatttaacattttcactagatcattggttgttagccacagcgcaacttatttatatgatacgtattggattacagattgccaacttaatgagtgatttaaagggaagaattgcaatagcaatagcctttcaaaatataatgctcatagtcacaacgtttataatgataataggaatacatttgattactaatgaatccatcaatgaattgtttttaggagcagcaccaggaggtatgagtcaaatagttttagtggctatggctactggagctgatgtagcgatgatttcaagctatcacatttttagaatattttttatattatttgtcattgcgccactaattggttattttattaatgttaaattaaataataaa |
534. | gtgaagaaaacgagtagaataattgcattcatactcctcatagctctactattcacaggaatgggtatgacgtataagaatgtagttaaaaatgttaatttaggtctagatttgcaaggtggttttgaagtcctcttccaagtagatcctttaaataaaggagataaaattgataaaaaagcacttcaagctacatctcaaacattagaaaatcgtgtaaatgttctaggtgtatcagaaccgaaaatacaaatcgaaagatcaaatcgaattcgtgtacaattagcaggtatcaaggatcaagcacaagcgcgtaaattattatcgacacaagctaatttaacaattagagatgctgaagatcatgttttaatgtctggttcagacattaaacaaggctctgctaaacaagaatttaaacaagaaactaatcaaccaacagttacatttaaagtaaaaagtaaagataaatttaagaaagtaactgaaaagatttctaaaaaacgtgacaatgtcatggtagtttggttagatttcgaaaaaggcgatagttacaagaaagaagctaaaaagcaacaagaaggtaaaaagcctaaatttatatctgcagcgagtgtagaccaacctattaattctagtagtgttgaaatttcaggtggcttcaatgggaaaaaaaggtgttgugaagcgaaacaaatagctgagttattaaatgccggctcattaccagttgatttaaaagaaatttactctaactctgttggtgcacaatttggtcaagatgctcttgataagaccatgtttgcatcaattgtaggtatagcattaatttatttatttatgcttggtttctatcgtttgcctggtttagttgcaatcattgccttaaccacttatatttatttaactttagtcgcattcaatttcatatcaggtgtattaactctacctggattggcggcattagttttaggtgtaggtatggctgtcgatgccaatatcataatgtatgaacgtattaaagatgaactaagaattggacgcacgcttaaacaagcgtattcaaaagcaaataaaagttcattcttaactatatttgattccaacttaacaactgtcatcgctgcagctgtgcttttcttctttggagaaagttcagtcaaaggcttcgcaaccatgttactcttaggtattttaatgatatttgtaaccgcagtattcttatcaagagggttgttatcattactggtatcttcaaacttctttaaaaaacaatactggttatttggtgttaagaagaaggatagacatgatattaatgaaggtaaagatgtacatgatttaaaaacatcatatgaaaggttaaactttgttaaattagctaagccacttatttcacttagtattttaattgtaattattggtttgattatcatttcaatatttaaattaaacttaggtattgatttctcatccggaacaagagcagatattcaatctaaaaatgctataacacaagcacaggttgagaaaactgtaaaatcagttggattggaaccagatcaaatacagattaatggtagtggaaataaaaatgccacagttcagtttaaaaaagatttatcacgtgaggaagacaataaattaagtgctaaggtgaaatctgaatttggagataatccacaaattaataccgtttcacctctcataggccaagagctagctaaaaatgctgtaactgcattaatacttgcttctataggcattattatctatgtttcactaagatttgaatggcgtatgggtctatcttctgtacttgcattattacatgacgtatttatcatcattgcaatctttagtttgtttagattagaagtagatttaacatttattgcagcagtattaactatcgttggttattcaatcaatgatacaatcgtaactttcgaccgtgttcgagaaaatctgcataaagttaaagtaattacgcatactgatcaaattgatgatatagtcaaccgctctattagacaaactatgacacgttctattaatacagtgttgactgtagttgtagttgtagttgcaatattaatattaggtgcaccaacaatatttaatttctctttagcattactaattggattattatctggtgtattctcgtcaattttcattgctgtaccattatggggcatgcttaagaaacgacagtttaaaaagacaaaaaataataaattagtagtacacaaagagaagaaatctaacgatgaaaaaatcttagtt |
535. | atgggggaaaatacaaaacaagatttcaatcaaaaaggacaaaattttaaattcacaaaaaaacatagacgattattatatggttcagtttttttaatggctacatcagctattggtccagcatttctgactcaaactgcagtgtttactgcacaattttatgctagttttgcatttgcaatattaatttctattattatagatataggcgctcaaataaatatttggagaatattagtggtaactggattacgtggacaagaaatatctaataaagtattacctggacttggtactattatctccatactaattgcatttggtggtctcgcatttaacataggtaatattgctggtgcaggtttaggtttaaatgcaatgtttggtcttgatgtaaaatggggtgctgcaataacagctatttttgcgatacttatctttgttagtagaagtggtcagaaaataatggatgttattagtatgattctaggtatcgtaatgattttagtagtcgcttatgtcatggttgtttcaaatcccccttatggagatgcattagtacatacatttgcacctgaacatcctttcaaacttatattacctataattacattagttggtggtacagtagggggttatattacttttgcaggtgcacatagaattctagattctggtataaaaggtaagtcataccttcctttcgtaaatcgatctgctgtagcaggtattttaacaactggtgtcatgcgcaccttattgtttttagctgtactaggtgttgttgtaactggcgttacgcttagttcagaaaatccaccagcatcagttttccaacatgcattaggtcctataggtaaaaatatttttggcgtagtaatatttgcagcagcaatgtcctcagtaattggttctgcatatacaagcgcaacatttttaaaaacactacacaaatcgttactcaataaaaataatcttatcgttattacatttattgtaatttcaacttttgttttcttatttattggtaaaccggtgagtttacttataatagctggtgcgattaatggttggattctaccaatcacattaggtgcaattctcattgcaagtaggaaaaaatctatcgttggtaattaccaacacccaacatggatgcttgtttttggtattatagccgtaattgtcacaataatgactggtatcttttcattacaagatttagcaagtctttggaaaggt |
536. | gtgtctaataataattttaaagatgatttcgaaaagaatcgtcaatctattaatccagacgaacatcaaacagaattaaaagaagatgataaaacaaatgaaaataaaaaagaagctgactctcaaaacagtttatctaataactcaaatcaacaatttcctccgagaaatgcccaacgacgaaaaagacgcagagagacagcaactaatcaaagcaaacaacaagacgacaaacatcaaaaaaatagtgacgctaaaactacagaaggttcattagatgaccgttatgacgaagcacagttacagcaacaacatgataaatcgcaacaacaaaataaaactgaaaaacaatcacaagataatagaatgaaagatggaaaagatgcagctattgtaaatggaacatctgagtcaccagaacataaatcaaaatcaacacaaaatagacccggccctaaagctcaacaacaaaagcgtaaatcagaaagtacgcaatcaaaaccgtcaacaaacaaagataaaaaagcagctacaggtgctggaatagctggtgcagctggtgttgctggtgcagcagaaacatccaaacgtcatcataataaaaaagataaacaagattctaaacactcaaaccatgagaatgacgaaaaatctgttaaaaatgatgaccaaaagcaatctaaaaaaggcaaaaaagcagcagtcggtgctggcgcagctgcaggagttggtgcggctggtgttgcgcatcataataatcaaaataaacatcataatgaggaaaaaaattctaatcaaaacaatcagtacaatgaccaatcagaaggtaagaaaaaaggtggtttcatgaaaatcttgttaccacttatagcagccattcttattctaggtgcaatagcaatattcggtggtatggctctaaataatcacaacgatagtaaaagtgatgaccaaaaaatagcgaatcaaagtaagaaagactcagataaaaaagatggtgcgcaatccgaagataacaaagacaaaaaatctgatagtaacaaagacaaaaaatctgattctgataagaacgcagatgatgactctgataatagttcctcaaatcctaacgctacttcaactaataataacgataatgtagccaataataactcaaattatacaaaccaaaatcaacaagataatgcaaaccaaaatagcaataatcaacaggcaactcaaggtcaacaatcacatacagtatacggtcaagaaaacttatatcgtatcgccatacaatattatggagaaggaactcaagctaacgtagataaaattaaacgtgcgaatggattaagcagtaataatattcataatggtcaaacattagttattcctcaa |
537.. | atggctaaaggggaccaatatcaagctcatactgaaaaatatcatgataaaaagtctaaaaaaagttataaacctgtgtggattatcattagttttattattttaattacaatcttgttattacccacaccagcaggattacctgtaatggctaaagcagcactagctattttagctttcgctgtagttatgtgggttacagaagcagttacttatccagtttctgcaacattaattttaggattaatgatacttttactaggtttaagtccagttcaagatttatccgaaaaacttggaaaccctaaaagtggcgacataatactaaaaggtagcgatattttaggaacgaataacgcgcttagtcacgcttttagtggtttttcaacctcagccgtagcacttgtagctgcagcattatttttagcagtagctatgcaggaaaccaatttacataaacgacttgcattacttgtgctatcaattgttggaaataaaactagaaatatagtcattggtgctattttagtatctattgttctagcattctttgtaccatcagctacagcacgtgctggtgcagttgtcccaatattactgggaatgattgctgcatttaatgtgagtaaggatagtagacttgcttcattattaattattactgctgtacaagcagtttcgatatggaatataggtattaaaacggctgcagcacaaaatattgtagccatcaattttattaaccaaaatttaggacatgatgtatcatggggagagtggtttttatatgctgcgccgtggtcaatcattatgtctatagctctttattttataatgattaagtttatgccacctgaacatgatgcaattgaaggtggaaaagagttaattaaaaaggaacttaataaattaggaccagtcagtcatagagaatggcgactaattgtgatttcagtgcttttattattcttctggtcgactgagaaagtattgcatccgattgattcagcttcgattacactagttgctctaggtattatactaatgccaaagattggtgttattacttggaaaggtgttgaaaagaagattccttgggggacgattatagtatttggtgtaggaatctcacttggtaatgtattacttaaaacaggagccgctcaatggttaagtgatcaaacatttggtttgatgggtcttaaacatttaccgatcatagcaactattgcgttaattaccttatttaatatattaatacatttaggttttgcaagtgcaacgagcttagcctctgcgttaatacctgtgtttatttctttgacttcaacgctaaatttaggtgatcatgctattggttttatattaatacaacaatttgtgattagttttggtttcctactacctgtcagtgcaccacaaaatatgcttgcatatggtactgggacttttaccgtaaaggattttttaaagacaggtatacctttaacgatagtaggttatattttagttatcgtatttagtttgacgtattggaaatggcttggtttagtg |
538. | atgttagatttcattaaccatttgcttagttatcaatttttaaatcgtgcattaatcacatctattttagttgggattgtatgtggaacgatgggtagcattattgttttacgtggtctttctttaatgggtgatgccatgagtcatgctgttttaccaggtgttgctttatctttcttatttaatattccaatgtttatcggggcacttgtaacgggaatgcttgcaagtttgtttattggttttattacttcaaacagtaaaacaaaaccagatgctgcaataggaataagtttcactgcattcctagcatctggcgtcataattattagtttaatcaatagtacaacagatttatatcacattttatttggcaatttattagcaattacacatcaatcattttggacaacaattgtcattactgtactggttattttacttattattatcttttatagacctttaatgatttcaacatttgatgcaacttttagtcgtatgagcgggctgaacacaacattaattcactactttgtcatgttattactcgcacttgtaactgttgcgagcatacaaacagttggaattatccttgtagttgctttactaatcactccagcttctacagcttttttaatcagtaaacaactttatgccatgatggtaattgcaagcataatcagcgtgataagttcgattatcggtctatattttagttatatatataatattccaagtggagcaactattgtaatctgtacctttatgatttatattgtaacgctatcaattactagaattaaaaataaacaaaaaaggagcgctttaacg |
539. | ttggcaaagctattatacaaactaggaaaatttatagctaagaacaaatggctaagtgttataggatggcttgttatactaggtgttattatcacgccattaatgataaactcaccgaagtttgacagtgacatcactatgaacggccttaagtcattagacacaaacgataaaatcagtaaagaatttcatcaggacagtgagaaagcctcgatgaaaatagtcttccattctaataagaatgatggactcaataataaagatacgaagaaagatattgaagatgctttagacaatatcagacaaaatgatgattatatccaaaatatctctaatccatatgacagtggacaagttaatgatgaaggcgatactgctatcgctaacgtaagttatgtagttccacaaactggattaaaagattcttctaaacatatcatcgacaaagaattaaaagatgtaactgacaaccataatgtgcaaattgaaaaaactcaaggtggcgctatgaattccgaacctggtggtacatcagaaattgtcggtatcatcgtagcattcgtaatcttacttattacctttggttcacttatcgcagctggtatgccaattattagtgcaatcatcggtttaggttcaagtgttggtatcatcgcattattaacatatatctttgatattccaaacttcactcttacactagctgtaatgataggtttagctgttggtattgactactcactctttattctatttagatttaaagaacttaagaaaaaaggtgtcgatactgtagaagctattgcaacagcagtgggtacagcaggcagtgctgtaatattcgctggtcttacagttatgattgctgtttgtggtttatcacttgtaggaatcgacttcttagcggttatgggattcgcttcagcgattagtgtgttatttgcagtattagcagcattaacactattacctgccctaatcagtatcttccataaaagtattaaaattaaagataaaccaactaaaagtaaagaccctaaagatcattcttgggcaaaatttattgttggtaagccagttatcgctgttattgtaagtttaattattttaattttagctgctataccagtcagtggcatgcgtttaggtattccagatgatagtttaaaaccaactgactcatcagaatacaaagcctataaattaatctcagataattttggcgaaggttataacggacaaattgtcatgttagtaaatacaaaagatggtggaagtaaaagcactatcgaacgtgatttaaataatatgcgtagtgatttagaagacattgataatgttgatacagtttcaaaagcacaactaactgacaacaacaattacgcattattcacaatcattcctgaaaaaggaccgaactcacagtcaacagaaaatctagtatatgatttacgtgattatcatagccaagcgcaagaaaaatatgactatggcactgaaatttcaggacaaagtgttattaacatcgatatgtcagaaaaactaaacaacgctattccagtatttgcaggcgttattgttgtattagcattcttcttattaatgattgtgttccgttcgatcttagttccattaaaagcagtactaggctttatcctttcattaatggctacattaggtttcacaacattagtcattcaacatggctttatgggtagcttatttggtattgaaaacacaggaccattacttgcattccttccagtaatcacaattggattgttattcggacttgccatcgactacgagctcttcttaatgacacgtgtacatgaagaatacagtaagactggcgataatgatcattcaatccgtgtaggtatcaaagaaagtggacctgttatcgtagctgctgcacttattatgttcagtgtattcatcgcattcgtcttccaagatgacagtgcaattaagtcaatgggtatcgcattaggtttcggtgtgttattcgacgcattcgtcgtacgtatgacattaattccagcattgacgaaactctttggtaaagcttcatggtaccttcctaaatggttaggtgcagtattgccaaacgttgacgttgaaggtaaagctttagaagaagataatcatcacgacacatcttctgaaaaaggtcatgtcaacgataaaaatagtgaatactctagacaagacaaagataactatgtttatcaaaatgacaaacgtaactacaatcgcaattataatgacgaagattataaccgttctgtgcatttaaataatcatcatgaccagcatcatcgccaacatcaatatgataatcaacgtgatgatatcgactatgaatcactttatactcaagatggcgaccatactcatcatgatgaacgtaattataatgatcgacactatcaagacaattacgatagaaatgatgattatcgtcacaacaatcatgatcatcaaaatgataaccatgattatcatgattcaaattttgataaaacaacaaacttatacaaagaattaactgatagcaatattgatcaagatgtattattcaaagcattaatgttatacgctcgtgaaaacaacaaaggtgtttacgatagatataaccgatcatctcaacatcgtcatgatgacgaacttagagac |
540. | atgaataaaaaagtagaacatatcggtaaccaatatacgtcacaagaaaataagaaaaaacaacgacaaaaaatgaaaatgcgtgttgtacgtagacgtattgctttattcggaggtattcttttagcgattatcctcattctacttgtattgcttgtcattcaaagacataataacgatcaagatgcagttgaaaggaaagagaaagaaactgagtttcaaaaacaacaagatgaagaaattgctttaaaagagaaacttaataatttaaatgataaagactatatcgagaaaatagcgagagacgattattatttaagtaataaaggtgaagtcatttttagattacctgatgataaaaaatcctctcagtcaaagacttcaaacgaaaaaggcaat |
541. | atgaagatacgtttaacatttattatcttagcaatactatccaccatcggcttagtacttgttttagcaaaatatccaacaggcccacacacaatcaactataacgaaccttatacagtactcatagccattacgacaatagttataatggctttaccagcactcatattaggtatatttaatcatcttgcatgtagaatcatatcggcgatattacaaataagtgcactgatgatgtgggggtttttagtaatcattagcttaattatgggacaaattgtcattatgcttatggcttccttaacgatacttgcattacttgttagttctattgtcacactttcagtgcacccatctacttcagataaaataaat |
542. | atgaataagaaactattgtggagcatcattggtattgtaattattgtcgtattaatcattgctgcttttatattaaaacaagttaatggttcaggtagtaaagatagtaatgcttacgatacatatacagtaagaaaagaaacacctattagtttagaaggcaaagcgtctccagaatctgtgaaaacttataacaataatcaatctgtgggtaacttcttaagtgtttcagtacaagatggtcaaacagttaaacaaggtgaacgtatcatcaattatgatacaaatgggaataaacgccaacaactattgaacaaagtgaatcaagcacaatctcaagttaatgatgattatcaaaaagtaaatcaaagtcctaacaatcatcaattacaagttaaattgactcaagatcaaagtgctttaaatgaagctcagcagtcattgtcacaatatgacagacaactcaatgacagcatgaatgcatcatttgatggtaaaattaacattaaaaatgattcagatgtaggcgaagggcaacctattttgcaattaatttcttcaaatcctcaaattaacgcaactattacagagtttgatattaataaaattaaagaaggcgatgaagtaaatgtcactgtaaatagcacaggtaaaaaaggaaaaggaaaaattcttaaaatagatgaacttcctacaagctatgatacaagtgacgatagtacagcatcatcggcacaagcaggggcacaaggtgatagtgaagaaggaactgaaatgacgacatctaatcctacaattaatcagccaacaggtggtaaaagtggcgaaacatcaaaatataaagttatcattggtgatttagatatacccgtgagatcaggcttctctatggatgctaaaatccctcttaaaactaaaaagctaccaaataacgtgttaacaaaagataataacgtatttgtcgttgataaaaataataaagttcacaaacgtgaaattaaaattgaacgtaataatggtgaaatcattgtgaaaaaaggattgaaatctggcgataaagtccttaaaagtccaaaaggtaatttaaatgatggagaaaaagtagaggtgtcatca |
543. | atggctgaaactactaaaatatttgaatcacatttggtcaaacaggctctaaaagacagtgtattgaagctctatcctgtttatatgattaaaaatccgattatgtttgttgtagaagtgggcatgctgcttgccttaggattaaccatttatccggatttatttcaccaagaaagtgtatcacggctatatgtgttcagtatctttatcatattattactgacacttgtctttgcgaacttctctgaagcattagctgaaggtcgcggtaaagcacaagccaacgctttacgccaaacacaaactgaaatgaaggcacgtcgtattaaacaagacggcagttatgaaatgattgacgctagtgacctgaaaaaaggacatatcgtacgtgtcgcgacaggtgaacaaatcccaaatgacggtaaagttattaagggcctcgcaacagtggatgaatctgcgattacaggtgaatctgcacctgtaatcaaagaaagcggtggagatttcgataatgtaattggaggaacttctgtagcttcagactggttagaagttgagattacttcagaaccaggtcattcatttttagataaaatgattggtttggttgaaggggctacaagaaagaaaacacctaatgaaattgcgttatttactttattgatgacattaacgattatcttcttggtcgttattttaacgatgtatccattggcgaaattcctgaatttcaatttatccattgcgatgctgattgctttggctgtgtgtttaattccaacaaccattgggggattattatcggctatagggattgcagggatggatcgtgtgacacagtttaatatcttggctaaaagcggacgttctgtagagacttgtggtgatgtgaatgtcttgattttagataaaacaggtaccattacctacggcaaccgtatggcagatgcgtttattccggtgaaatcatcaagctttgaacgtttagttaaagcggcctatgaaagttctatcgcagatgacacaccagagggacgtagtattgtgaaattagcttataaacaacatatcgacttaccgcaagaggtcggagaatatattccgtttactgctgaaacacgtatgagcggtgtgaaatttacgacacgtgaagtatataaaggtgcaccgaatagtatggttaagcgtgtgaaagaagcagggggacatattccagttgatttagacgctcttgtcaaaggggtgtctaaaaaaggtggcacaccgctggttgtgcttgaagataatgagattttaggtgttatttatttgaaagatgtcattaaagatggactcgtagaacgtttccgtgaattacgtgagatggggattgaaacggtgatgtgtacaggagataacgaattgacagctgcgacaatagcgaaagaagcgggtgtggatcgctttgtggcagagtgtaaacctgaagataaaatcaatgtgattagagaagaacaagcgaaaggtcatattgttgcgatgacgggtgacggtacgaatgacgcgccagctttagcagaagctaatgtaggtttggcaatgaactcaggaaccatgagtgccaaagaagcggcgaatttaattgatttagattctaatccaaccaaactgatggaagtcgttctaattgggaaacaattattaatgacacgtggctcactcactacatttagtattgcgaatgacattgcgaaatactttgcgattttaccagccatgtttatggcggctatgcctgcgatgaatcatttgaatattatgcatctgcattcacctgaatcagcagtattatctgcgttaatctttaatgcgttgattattgtattattgattccgattgcgatgaaaggcgtgaaatttaaaggtgcctcaacgcaaaccatattgatgaaaaatatgttagtttacggcttaggcggtatgatcgtgccatttatcggcattaagctcattgatctcatcatccaactctttgtc |
544. | atgattgtgttacgtcgtctatttcaagatagaggtgccatatttgctatagctattattacaatctacgtagtgcttggagttttagctcctttaattacattctatgaaccgaatcacattgatacagcaaataaatttgctggtataagttggtctcactggttgggaacagaccatttaggtcgagatgtattaacacggataatatacgccataagacctagtttgttatatgtatttgtcgcattgattatttccgttgtgataggagcgatacttgggtttatttcaggttatttcccaggttatatcgatgcaataattatgcgtatatgcgatgtgatgttagcttttccaagctatgtggtcacattggcattgattacgttgtttggcatgggtgtagaaaatattattattgcatttatattgactcgatgggcgtggttttgtcgcgtgattcgaaccagtgtaatgcaatatattgaagctgatcatgtaaaatttgccaaagtaattggtatgaatgatttaacaatcattcgcaaacatattttgccactaacctttactgacatagcgattattgctagtagttcgatgtgttcaatgatattacaaatgtcaggattctcattccttggattaggtgttaaggcacctacagccgaatgggggatgatgcttaatgaagcacgaaaagtaatgttcacacatcctggaatgatgatgacaacaggtgtggctatcgtcataattgtgatggcgtttaactttttatcagatgctttacaaatggcgattgatcctcgtatgtccgctaaagaaaaacgactggctctgaagaaaggtgtgaaagcacgtgacactgct |
545. | atgaaaggtgccatgtcttggccttttttaagattatatattttaacattgatgttttttagtgcgaatgccatactcaatgttttcatacctctaagaggacatgacttgggggcgacgaatactgtaattggaattgtaatgggagcttatatgctaacggcaatgctatgtcgcccctgggctggtcaaattattgcacgtattggtccgattaaagtattgcgtattatattattgattaatgctatggcactggtattatatgggtttacaggacttgaaggttatttgattgcacgtatcatgcaaggtgtgtgtacggcattcttctcaatgtctttacaattgggtattatagatgctttacctgagaaatatcgttcagaaggtgtatctctctattcattattttcaacgattcccaatttattaggaccattaattgcagttgggatttggcacgtggaaaatatgtccatatttgctattgttatgatttttattgcagtaacaacaaccttatttggttatagaactacttttgcaaatacacaaaaagaggtatcaccaaaagacgaagtcttgccttttaatgcaatgactgtatatgtccaattttttaaaaataaagcactcttctgcagtggtatgattatgatcttgtcatctatcgtgtttggtgcgatgagtacttttataccattatatacggttagggaaggtttcgcgaatgcaggtattttcctcacaattcaagccattacagtagtgatagctagattttatttacgtaagtatgtaccatctgatggtttatggcatcaccgttttatgatgattgtcttaacgttactgatggttgcttcagtcattgtagcttttggaccacatatagtgagtatatttgtatatataagtgcaatctttatcggaataacacaagcgctcgtttatcctacattgacaacgtatttaagttttgtcttaccaaagataggacgtaatatgtysttaggattgtttatagcatgtgcagatttagggatttcactaggaggtgtgctaatggggccaatatcagatacggtaggatttaaatggatgtatattttatgcgctttattggttactattgcaatgacactaagtaaaattagacaaagacaaagtgtttcaaaagcctca |
546. | gtgggaagtactgttaaatatcgtaagtttattctacctattgtcgttggtttaattatctgggcattgacgcctattaaaccagatgccttaaatgatcaagcttggtttatgtttgctatttttgtgtcaaccatcattgcttgtattacccaacctatgactataggtgcagtatcaatcattggttttacaatcatgattttggttggaattgttgatacaaaaactgccgttcaaggcttcggtaatagtagtatttggcttattgcaatggcctttttcatttcaagaggatttgtaaaaacagggctaggtcgacgtattgctctgcaattcgttaaattatttggaaagaaaacgcttggtttggcttattcacttgttggtgttgatcttatcttagctcctgctacgccaagtaatacagcacgtgctggtggtattatgtttccaatcattaagtccttgtcagagtcatttggttcatcgccgagagatggttctgagagaaaaatgggtgcgtttttaatctttactgagttccaaggtaatttaattacttcagctatgtttttaacagctatggccggtaaccctatagcgcaaagtttagctgaaaaaacggcacacgttcaaattacatggatgaattggtttgttgctgctattatacccggattgatttctctcatcgttgtccctttcattatttataaattatacccaccaactgttaaagaaacgcctaacgctaaaaaatgggctactgaacaactagaagaaatgggacatatgtctatagccgaaaaattgatggttggtatctttatcatagcattggctttgtgggtattaggaagcttcattaatgttgatgccacgctcactgcatttattgctttagcattgttactattaacaggtgtattagcgtggtcagatattttaaatgaaacaggcgcatggaatacactcgtttggttctcagttcttgtattaatggcagaacaattaaacaagttaggctttatcccatggttaagcaaactcattgctcaaggtttaaatggctttagttggcctatcgttttagttttactcatcttgttttatttctactcacattatttattcgcaagtgcaacagcacatgtcagcgccatgtacgccgcgttactcggtgttgcagtcgcttcgggtgcaccgccattattcagtgcattaatgttagggttctttggtaacttactggcatcaacaacacactatagtagtggaccagcgcccatattatacgcagctggctatgttacacaaaagcgctggtggactatgaatattgtacttggtatagtctattttattatttggattggtgtaggttcactatggatgaaactcataggtatgatg |
547. | atgaaagataataaaatgttgttcattatttttatgataggaacatttacagtaggaatggctgaatatgtagtgacaggattacttacacaaatcgctgacgatatgaaggtttctatttcgagtgcaggtttattaattagtgtttatgctattagtgttgcattgatagggcctttaatgcgaatcataacattgaaagttcacgcccaccgtctgttaccgattttagtagcgatttttataataagtaatttagtgggaatgttagcaccgaattttaatgtattgttattatcaagactcatgtctgcggcaatgcatgcgccattcttcggtgtgtgtatgagtgttgctgcgacagtcgcacctcctgctaaaaaaacacaggccattgcacttgttcaggcaggtttaactattgctgtaatgttaggtgtaccattcggatcatttttaggtggctttgcaaattggagagttgtttttggatttatgattgtgttggcaatcattactatgttaggaatgattaaatttgttccaaatgtttctttaagtgcagaagcaaatattagcaaagaattaacagtgtttaagaatccacacattttaattgtgattgcaattattgtgtttggttactctggtgtgtttactacttatacatttatggagccaatgatacgagatttttctccatttaaaattgtaggtttaactgtttgtttatttatgtttggtctaggcggtgtgatagggaatttaattactggtaatgtaccggaagataaattaacaaaaaatttataccttacatttcttttactatttgtaacaatcatactatttgttactgttattcaaaattcaatattagcattaatcatttgcttcttattcggttttggtacatttggtacaaccccgttacttaatagcaaaattatcttaagtggaaaagaagcaccacttcttgcaagtacgttagcagcttctattttcaatgttgctaattttcttggtgcaataattggatctatattattatcaatagggttaccttacattcaaattactttgatatctggtggaattatagtgttgggtatgcttcttaatcttgttaatcaactttatgaaaagaaacatatcacatttaatgaatattca |
548. | qvlkmlqnilllmllllmlkikvliylimtllnqfrdmvlklrfinnkslwaien |
549. | krlvmqqhlqfnlpkiillnaltkrflsllvtqlvmvfilvvsllkvpvqlq |
550. | lrlrqfqllctlvllmlvalfihaflrylmtk |
551. | rlrtsyiiklaatdafklltcptigili |
552. | ssvfairltitfsrfsnvgckkhikgaiimkkeiiewivaiivaivivtlvgkflfasvtvkgasnviyn |
553. | rsyphivvltmriiasvllvivgfslsvsca |
554. | tanniisfiitltniyktklmgvffniielrnkfirrcwailfiaiihfisecflphiptncyvsrrdfldsaknmsyktlnticrnsrrlvhkliv |
555. | ffcrltqlnwlkylsvrmlymyfmifsimnhivstic |
556. | ifistcgcsttsawkaevlplrvrfpspapf |
557. | lknilrivfiagltvffsgpgqtysnaafideyiqtfwsrtev |
558. | rnsnqmyqtftadivlifmiivlgglyyqvpmpilagimvmvsetiyclhl |
559. | nqrleetissphhssal |
560. | mkqflnitqrkfiewliilsifivsipnkwtlmisialsllllkrgalgvvqliilymlrsqiytpydtqemahyivsmkyiliyvigvfflfkyvkhwirnemilrfikstmilmllyiimslvvsndpiesilkllnffiplilivmyvslikkiknlinwinqfitlviaftflfiviapksylideeslrsvfkdahsfavilamglvlymvtiikqqdydvfnllllnigmielylsnsrhifisvilclmlllplshikkrikhpiigamilmaiaiinqpyiyhlfiklilkgknsqevfmpsdmnikaidyaltehpflgsgfgipmikasseiqyfnvatsniifgmiiftgiigltlctiymlhmvllvtfpmsitillflitifvnmdyiilfdsvglgilcyifwgiylkegmyqynngqw |
561. | mtngktvglvvapgvterlaenliqempkmlsthydhqqewifdlvtdpltgfaesvdeifgkvadyhdkrqwdyviaitdlpmfadkqvmaldinmebgaaifsypafgwrpvkkrfkhaiyniiqelneaeqesrnydnnkqiensvkkqfplskidketiymketdsyhlrylsssrsrgmfrlvsgmtfannplnmmaslsnivaiafttgafglvfttmwqmaynfsmwrlfgisiiaiigmliwimmshdlwepvnksnhkhitwlynlttimtlifaiiiyyiilyllfliaeivllpsgflgqqvglkgpagidlylsipwfaasistvagaigagllndelikestygyrqrvryeeqrr |
562. | mkfcphcgnpikkeqsfcnkcgkhlktstqrksenqiehmreqgsyisreerqhhdstfykeqkntqwllvlsllrvlliaallvgavvavnhvisdegshgttesqgsnesdgnrgqstgpsldvrsaaraqgymksastsgyrgvyngmtreevedktgtsngsveslkwsyetygalavayddneyysvgvapnnisedqtlsmynepddrnssqllydsnkdndtsvlanvkngavtvienvnqi |
563. | mllfiieiiimilaillglrtagalgcgifaivaqlimifgfqlppgsapvtavliilsigiaggtlqatggidylvyiasrvierfpksiifiapmivfvfvfgigtanialslepiiaktaqkariqpkraltasvltanlallcspaasatayiisvlagyeismgkylsivlptalismlmlstfctfvgrkehvrdeserlvqmpeveikndfslkykigvisfllcvmgiltfgifpnlmpqfnvngdvvkvemteivqffmylsatinlllikintsdilssnitqsamgalfavlgpgwlgatifnaphnlkiikndigsiisevpwlviilvsvvamivisqtatasimvpivmslgippiyfvamvqtlnvnfvipaqptllfaveldetgrtrptsfmigpffvitvsvitgrviktiigy |
564. | mgsffnrmtrkenptiyqnkdghlkrtlrvrdflalgvgtivstsiftlpgvvaaejagpavalsfllaaivaglvaftyaemastmpfagsayswinvlfgelfgwvagwallaeyfiavafvasgfsanlrgliaplgislpkslsnpfgsnggvidiiaavviiltalllsrgmneaarmanvlvilkvlaiilfvivgltainfsnyipfipehkvtetgdfggwqgiyagvsmiflayigfdsiaansaeainpqktmprgilgslivaivlfvavalvlvgmfhysqyadnaepvgwalresghgiiaaivqaisvigmftalignmlagsrllysfgrdgllpswlsqlnhkhlpnralviltiigvvigsmfpfaflaqlisagtlvafmfvslamyrlrkregkdlpkpefklplypilpaitfilvllvfwglsfeaklytliwfivgiiiyliygirhskkndeeayqvpre |
565. | mtkkkrlspsewllkqskrhkrkntlytaivllvalvllifavksiqvepvksdtrdkdsiritylgnvtlnkhirqtnlndvfkgiqdtldhsdfstgslivndfsrnqkdninknienimflrkhnvksvnlinesmdniqatammrkidsqagynfltgngsnpinsktvqqdikgkkianvsftdiesnytnslknttsisldpaifyplikklkenndyvvvnvdwgipnernvttrqkeyabalanagadviighntviqkveykxtpifyslgnttsdnflsknqkgmivqqdwkgshngnitpiqskdgkiskdnmnkmdhirfknnikdksidlksdgnggytfey |
566. | miehlgintpyfgilvslipfviatyfykktngffllaplfvsmvagiaflkltgisyenvkiggdiinfflepaticfaiplvrkrevlkkywldifggiavgtiiallliylvaitfgfgnqiiasmlpqaattaialpvsdgiggvkeltslavilnavvisalgakivklfkisnpiarglalgtsghtlgvaaakelgeteesmgsiavvivgvivvavvpilapill |
567. | mkrtdkyrdsykyddqyqnhrkrseedmyrqhqesqqransnratqsendreyenhperyyngrdyrreqqleeenekssktkkwllallvllllivairitrailnnnndkvsndpnvsqnykkevenqnddlnrqvdsaksdiknkkdtqsqidklqnqidqlkqneetnadskftkfyqnqldklknannaqlnnenqskvnnmledintkfaslkaklenilngsnsgn |
568. | mknkkglgiglitimiivcivlvimmfvggkkesvvgimkdsttidkmintknekieknvelpkdanvsvkkedfvmlfkdektgkitkvkkvnhdduphglmskihdmgnmkhgm |
569. | mamsllvslvvymmtltsdiledilsfklevimqfpyilssisliilfilfilkdmekiwvwllsivmiavismsgnvwsqqvplwsiiirtihligltlwlgslvviicyaikvklngltsvrrmllkvniiavimlvftqilmaidetntltlwnnvsawsiylvikiagiiammllgfyqtmralrqrqqvhrfalmtelligmililqvs |
570. | mknsrfsgfdwammvfvffvitmalsvilrdfgatigvkrfvfsikdlapfiaaivcilvfkhrkeqlaglkfsislkvierlllalilpliilmiglfsfntyadsfillqtsdlsvslltilighilmafvvefgfrsylqniletrmntffasivvgliysvftanttygveyagyhrlytrmfsmllgellratngrtlylatarnasmtralvrlrseetgdlrsmkvialsttlvgvsfiiisliiralvykttkqsldevdpnnylshiqdeepsqedasstsnhdvsskdetkqqdidndkhqskkpnksddalttsnykedassvnketdtthndnikdhstytedrnssvvndvkdelnevednkadtdksn |
571. | mennelqrglnarqmqmialggtigvglfmgatstikwtgpsvilayliagiflflimramgemiyinpttgsfatfasdyihpaagymtawsnvfqwvvvgmseviavgeymnywfpslpnwipgviavlflmaanlvsvkafgefefwfalikvvtivlmiiaglglilfgignggnpigisnlwshggfmpngfigfffalsivigsyqgveligisagetknpqtnivkavngvlwrilifyigaifvivsvypwnqlgsigspfvatfakvgitfaaglinfvvltaalsgcnsgifsasrmiytlakkgqmpkvftkvmkngvpfytvfavsmgiligallnvilpliidgadsifvyvysasilpgmipwfmilfshlrfrrlhpekvhnhpfkmpggaianyltimflllvlvgmllnketvvsvvigivfltavtlyyliryhkkefqi |
572. | lqdfdnlipgwfktfvqvgndliwsqyligllltagffftisskfiqlrmlpemfraltekpetlssgekgispfqafaisagsrvgtgniagvataivlggpgavfnmwiiafigaasafmeatlaqvykvhdkeggfrggpayyitkglnqkwlgivfavlitvtfafvfmtvqantiaeslntqynispvitgivlavitgiiifggvrsiatlsslivpimaivyigmvliilllnidqivpmigtiiksafgvqqvtggavgaailqgikrglfsneagmgsapnaaatsavphpvkqgliqslgvffdtmlvctataimillysglqfgdsapqgvavtqsalnehlgsaggifltvavtlfafssvvgnyyygqsnieflsnnkmilfifrcfvvllvfvgavaktetvwstadlfmglmaivniisiiglsniafavmkdyqrqrkegkrpvfqpenleinlfgietwgqhakmpkk |
573. | lkkeilewivaiavaialiaiitkfvgksysikgdsmdptlkdgervvvniigyklggvekgnvivfhankkddyvkrvigtpgdsveykndtlyvngkkqsepylnynekrkqteyitgsfktknlpnanpqsnvlpkgkylvlgdnrevskdsrsrglldkdqlvgkvslrywprserksnfnpnntkn |
574. | mfnkvwfrtgiffimlfiliklfmevhevfapiatiigsvflpflisgflfyiclpfqnilekwgfprwasittifigliaiiaivvsfiapiiisninnlikqtpslqkeaeqlinfslrqmdklpddvthrinkavksmgdgatsilsnsvsyitsfistvfllimvpffliymlkdhekfipaigkffkgerkvfvvdllkdlnftlksyiqgqvtvsiilgiilyigytiiglpytpllvlfagvanlipflgpwlsfapaailgiidgpstfiwvcvvtliaqqlegnvitpnvmgkslsihpltiivvilaagdlggftlilvavplyaviktlvsnifkyrqrivdkansnvkd |
575. | mntivkhtvgfiasivltllavfvtlytnmtfhakvtiifgfafigaalqllmfmhltegkdgrlqsfkvifaiiitlvtvigtywvmqgghsshl |
576 | mlgeqytqikrpanrltekilgwfswvflliltivsmfialvsfsndtsianlentlnnnelvqqilanndlsttqfviwlqngvwaiivyfivcllisflalismnirilsgllfliaaivtiplvllivtliipilffiiammmfarrdrietvpsyyneydqpyydergfyepesrnehgynddvyepmhtkkedrntrrqfnrnaqqqdsyngitdnqpdedtssdqlysdeyvdnedkysqfpkraveseyasqqtedeptvmsrqakynkkskntdfedaqqehmegnqfddvgvvepqidpkelkaqrkrekaeirakkkekrkaynkrmkerrknqpsavnqrrmnyeerrqminneqedtdnnlnqqedskken |
577. | meenknqpnnenmsnkddntihlndsqsnedlelfrrnknarqrrrrridnqskekdatstqsqletkpmdkfidnhkshnqdkeiksdliednvndeddnqkynndklndrsvqqtsetrqsnedeeefltdhqsekqtkdsrhskkhkllskftskkeketftsfnsnekvtqikplsleekrairrkkqkriqytiitlliliivlillymftplskisnvnikgnnnvstskikkelnvtsrsrmytfsknkairnlkqnplikevdihkqlpntltvnvteyqivgleknkdkyvpiiedgkelteykdevshdgpiidgfkgdkktriikalsemspkvrnliaevsyaptknkqsrikiftkdnmqvigdittiadkmqyypqmsqslsrddsgelktngyidlsvgasfipyqgsstvqsgteqnvtkstqeendakeelqnvlnkinkqskenn |
578. | mkclfkmlsiiiimlstftlfispstyanedenwtkiknrgelrvglsadyaplefektihgkteyagvdielakkiakdnhlklkivnmqfdsllgalktgkidiiisgmtttperkkevdftkpymitnnvmmikkddakryqnikdfegkkiaaqkgtdqekiaqteiedskisslnrlpeallslksgkvagvvvekpvgeaylkqnseltfskikfneekkqtciavpknspvlldklnqtidnvkeknlidqymtkaaedmqddgnfiskygsffikgikntilislvgvvlgsilgsfiallkiskirplqwiasiyieflrgtpmlvqvfivffgttaalgldisalicgtialvinssayiaeiiraginavdkgqteaarslglnyrqtmqsvvmpqaikkiipa;gnefvtlikessivstigvseimfnaqvvqgisfdpftpllvaallyflltfaltrvmnfiegrmsasd |
579. | mshkilvsdpisedglqsilkhpefdvdiqtdlsendlvnmistydalivrsqtqvteriinaatnlkviaragvgvdninieaatlkgilvinapdgntisatehsvamllamarnipqahqslrnkewnrkafrgvelygktlgvigagriglgvakraqsfgmkilafdpyltedkaksldiqiatvdeiaeksdfvtvhtpltpktrgivgssffnkakqnlqiinvarggiidetaliealdnnlidraaidvfehepptdspliqhdkiivtphlgastveaqekvavsvseeiieiltkgnvehavnapkmdlskvdkttqsfiglsttigefaiqlldgapseikvkyagdlaqndtslitrtiitnilkedlgnevniinalailnqqgvtyniekqkkhsgfssyielelvndqdkikigatvfagfgprivrindysldfkpnqyqlvtchkdkpgivgqtgnllgshginimtlgrndaggdalmilsidqqaseevikilnetsgfnkiistklti |
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581. | vkktsriiafilliallftgmgmtyknvvknvnlgldlqggfevlfqvdplnkgdkidkkalqatsqtlenrvnvlgvsepkiqiedpnrirvqlagikdqaqarkllstqanltirdaedhvlmsgsdikqqgsakqefkqetnqptvtfkvkskdkfkkvtekiskkrdnmvvwldfekgdsykkeakkqqegkkpkfisaasvdqpinsssveisggfngkkgveeakqiaellnagslpvdlkeiysnsvgaqfgqdaldktmfasivgialiylfmlgfyrlpglvaiialttyiyltlvafnfisgvltlpglaalvlgvgmavdaniimyerikdelrigrtlkqayskankssfltifdsnlttviaaavlfffgessvkgfatmlllgilmifvtavflsrgllsllvasnffkkqywlfgvkkkdrhdinegkdvhdlktsyerlnfvklakplislsiliviigliiisifklnlgidfssgtradiqsknaitqaqvektvksvglepdqiqingsgnknatvqfkkdlsreednklsakvksefgdnpqintvspligqelaknavtalilasigiiiyvslrfewrmglssvlallhdvfiiiaifslfrlevdltfiaavltivgysindtivtfdrvrenlhkvkvithtdqiddivnrsirqtmtrsintvltvvvvvvaililgadtifnfslalligllsgvfssifiavplwgmlkkrgfkktknnklvvhkekksndekilv |
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584. | makgdqyqahtekyhdkkskksykpvwiiisfiilitilllptpaglpvmakaalailafavvmwvteavtypvsatlilglmilllglspvqdlseklgmpksgdiilkgsdilgtnnalshafsgfstsavalvaaalflavamqetnlhkrlallvlsivgnktrnivigailvsivlaffvpsataragavvpillgmiaafnvskdsrlaslliitavqavsiwnigiktaaaqnivainfinqnlghdvswgewflyaapwsiimsialyfimikfmppehdaieggkelikkelnklgpvshrewrlivisvlllffwstekvlhpidsasitlvalgiilmpkigvitwkgvekkipwgtiivfgvgislgnvllktgaaqwlsdqtfglmglkhlpiiatialitlfnilihlgfasatslasalipvfisltstlnlgdhaigfvliqqfvisfgfllpvsapqnmlaygtgtftvkdflktgipltivgyilvivfsltywkwlglv |
585. | mldfinhllsyqflnralitsilvgivcgtmgsiivlrglslmgdamshavlpgvelsflfnipmfigalvtgmlaslfigfitsnsktkpdaaigisftaflasgviiislinsttdlyhilfgnllaithqsfwttivitvlvilliiifyrplmistfdatfsrmsglnttlihyfvmlllalvtvasiqtvgiilwallitpastafliskqlyananviasiisvissiiglyfsyiynipsgativictfmiyivtlsitriknkqkrsalt |
586. | lakllyklgkfiaknkwlsvigwlvilgviitplminspkfdsditmnglksldtndkiskefhqdsekasmkivfhsnkndglnnkdtkkdiedaldnirqnddyiqnisnpydsgqvndegdtaianvsyvvpqtglkdsskhiidkelkdvtdnhnvqiektqggamnsepggtseivgiivafvillitfgsliaagmpiisaiiglgssvgiialltyifdipnftltlavmiglavgidyslfilfrfkelkkkgvdtveaiatavgtagsavifagltvmiavcglslvgidflavmgfasaisvlfavlaaltllpalisifhksikikdkptkskdpkdhswakfivgkpviavivsliililaaipvsgmrlgipddslkptdsseykayklisdnfgegyngqivmlvntkdggskstierdlnnmrsdledidnvdtvskaqltdnnnyalftiipekgpnsqstenlvydlrdyhsqaqekydygteisgqsvinidmseklnnaipvfagvivvlaffllmivfrsilvplkavlgfilslmatlgfttlviqhgfmgslfgientgpllaflpvitigllfglaidyelflmtrvheeysktgdndhsirvgikesgpvivaaalimfavfiafvfqddsaiksmgialgfgvlfdafvvrmtlipaltklfgkaswylpkwlgavlpnvdvegkaleednhhdtssekghvndknseysrqdkdnyvyqndkrnynrnyndedynrsvhlnnhhdqhhrqhqydnqrddidyeslytqdqdhthhdernyndrhyqdnydrnddyrhnnhdhqndnhdyndsnfdkttnlykeltdsnidqdvlfkalmlyarennkgvygrynrssqhrhddelrd |
587. | makkvehignqytsqenkkkqrqkmkmrvvrrrialfggillaiilillvllviqrhnndqdaverkeketefqkqqeialkeklnnlnndkdyiekiarlddyylsnkgevifrlpddkkssqsktsnekgn |
588. | mkirltfiilailstiglvlvlakyptgphtinynepytvliaittivimalpalilgifnhlacriisailqlsalmmwgflviislimgqivimlmasltilallvssivtlsvhpstsdkin |
589. | mnkkllwsiigiviivvliiaafilkqvngsgskdsnaydtytvrketpislegkaspesvktynnnqsvgnflsvsvqdgqtvkqgeriinydtngnkrqqllnkvnqaqsqvnddyqkvnqspnnhqlqvkltqdqsalneaqslsqydrqlndsmnasfdgkinifkndsdvgegqpilqlissnpqinatitefdinkikegdevnvtvnstgkkgkgkilkidelptsydtsddstassaqagaqgdseegtemttsnptinqptggksgetskykviigdldipvrsgfsmdakiplktkklpnvlttkdnnvfvvdknnkvhkreikiernngeiivkkglksgdkvlkspkgnlndgekvevss |
590. | maettkifeshlvkqalkdsvlklypvymiknpimfvvevgmllalgltiypdlfhqesvsrlyvfsifiillltlvfanfsealaegrgkaqanalrqtqtemkarrikqdgsyemidasdlkkghivrvatgeqipndgkvikglatvdesaitgesapvikesggdfdnviggtsvasdwleveitsepghsfldkmiglvegatrkktpneialftllmtltiiflvviltmyplakflnfnlsiamlialavclipttiggllsaigiagmdrvtqfnilaksgrsvetcgdvnvlildktgtitygnrmadafipvksssferlvkaayessiaddtpegrsivklaykqhidlpqevgeyipftaetrmsgvkfttrevykgapnsmvkrvkeagghipvdldalvkgvskkggtplvvledneilgviylkdvikdglverfrelremgietvmctgdneltaatiakeagvdrfvaeckpedkinvireegakghivamtgdgtndapalaeanvglamnsgtmsakeaanlidldsnptklmevvligkqllmtrgslttfsiandiakyfailpamfmaampamnhlnimhlhspesavlsalifnaliivllipiamkgvkfkgastqtilmknmlvyglggmivpfigiklidliiqlfv |
591. | mivlrrlfqdrgaifaiaiitiyvvlgvlaplitfvennhidtankfagiswshwlgtdhlgrdvltriiyairpsllyvfvaliisvvigailgfisgyfpgyidaiimricdvmlafpsyvvtlalitlfgmgveniiiafiltrwawfcrvirtsvmqyieadhvkfakvigmnaltiirkhilpltftdiaiiasssmcsmilqmsgfsflglgvkaptaewgmmlnearkvmfthpgmmmttgvalviivmarnflsdalqmaidprmsakekrlalkkgvkardta |
592. | mkgamswpflrlyiltlmffsanailnvfiplrghdlgatntvigivmgaymltamlcrpwagqiiarigpikvlriillinamalvlygftglegyliarimqgvctaffsmslqlgiidalpekyrsegvslyslfstipnllgpliavgiwhvenmsifaivmifiavtttlfgyrttfantqkevspkdevlpfnamtvyvqffknkalfcsgmimilssivfgamstfiplytvregfanagifltiqaitvviarfylrkyvpsdglwhhrfmmivltllmvasvivafgphivsifvyisaifigitqalvyptlttylsfvlpkigrnmllglfiacadlgislggvlmgpisdtvgfkwmyilcallvtiamtlskirqrqsvskas |
593. | vgstvkyrkfilpivvgliiwaltpikpdalndqawfmfaifvstiiacitqpmtigavsiigftimilvgivdtktavqgfgnssiwliamaffisrgfvktglgrrialqfvklfgkktlglayslvgvdlilapatpsntaraggimfpiikslsesfgssprdgserkmgafliftefqgnlitsamfltamagnpiaqslaektahvqitwmnwfvaaiipglislivvpfiiyklypptvketpnakkwateqleemghmsiaeklmvgifiialalwvlgsfinvdatltafialalllltgvlawadilnetgawntlvwfsvlvlmaeqlnklgfipwlskliaqglngfswpivlvllilfyfyshylfasatahvsamyaallgvavasgapplfsalmlgffgnllastthyssgpapilyaagyvtdkrwwtmnivlgivyfiiwigvgslwmkligmm |
594. | mkdnkmlfiifmigtftvgmaeyvvtglltqiaddmkvsissagllisvyaisvaligplmriitlkyhahrllpilvaifiisnlvgmlapnfnvlllsrlmsaamhapffgvcmsvaatvappakktqaialvqagltiavmlgvpfgsflggfanwrvvfgfmivlaiitmlgmikfvpnvslsaeaniskeltvfknphiliviaiivfgysgvfttytfmepmirdfspfkivgltvclfmfglggvignlitgnvpedkltknlyltflllfvtiilfvtviqnsilaliicflfgfgtfgttpllnskiilsgkeapllastlaasifnvanflgaiigsillsiglpyiqitlisggiivlgmllnlvnqlyekkhitfneys |
595. | MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGALLVLISAPATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK |
596. | vkrlknfilgllivaivgfllfmviddsriqsyqdyflqfnwfqplliglaglliliglilvlsifkpthrkpglyknfddghiyvsrkavektiydtiakydgvrqpnvvsklynkknksfidikadrfvpnhvqvksltesiradiksnvehfteipvrklevnvrdqktsgpryl |
597. | msflrkhteiifsyiigivslftgliifinlplikqfkgdkkvdthvhnvweflnaffaeiikvmskfiggfpitsaiviivfgilvmllghtlfrtikydydisifflvigimyfiitlllmtqvygffaivfiipftvhigyivykdelnqdnrknhymwiivtygmsylitqislygridaneiesidilsvntffiimwllgqmaiwnflflrrslpltkeelgeeepelsrtnkgnvsnqtkvhlkqlqnktteyarktrrsvdldkirakrdkfkqkinsivdiqeddipnwmkkpkwvkpmyvqlfcgviilffaflefrmrnalfltgewelsqtqyvvewvtlllllfiiiiyiattltyylrdkyyylqlfmgsilffkfltefinimvhglllsifitpilllmliamivayslqlrek |
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Claims (34)
1.鉴定,分离和制备超免疫血清反应性抗原的方法,该抗原源自特异性病原体、肿瘤、倾向于引起自身免疫反应的变态反应原或组织、或宿主,这种抗原适用于给定种类的动物或人类的疫苗,该方法的特征为以下步骤:
-提供来自该给定动物的血浆库或来自人类血浆库或个体的血清的抗体制备物,其中含有针对所述特异性病原体、肿瘤、或倾向于引起自身免疫反应的变态反应原、或组织、或宿主的抗体,
-提供至少一种上述特异性病原体、肿瘤、或倾向于引起自身免疫反应的变态反应原、或组织、或宿主的表达文库,
-用上述抗体制备物筛选上述至少一种表达文库,
-鉴定在该筛选中与该抗体制备物中的抗体相结合的抗原,
-使用来自个体的个体血清的个体抗体制备物筛选所鉴定的抗原,该个体含有针对特异性病原体、肿瘤、或倾向于引起自身免疫反应的变态反应原、或组织、或宿主的抗体,
-鉴定所述已鉴定出的抗原的超免疫血清反应性抗原部分,且该超免疫血清反应性抗原结合源自该个体血清的个体抗体制备物的相关部分;以及
-可选分离所述超免疫血清反应性抗原,并通过化学或重组方法生产所述超免疫血清反应性抗原。
2.鉴定,分离和制备几乎全套特异病原体的超免疫血清反应性抗原的方法,这种抗原适用于给定种类的动物及人类的疫苗,该方法的特征为以下步骤:
-提供来自所述给定类型的动物血浆库或来自人类的血浆库,或个体血清的抗体制备物,其中含有针对所述特异性病原体的抗体,
-提供至少三种该特异性病原体的表达文库,
-用所述抗体制备物筛选所述至少三种不同的表达文库,
-鉴定在所述至少三次筛选中与该抗体制备物中的抗体相结合的抗原,
-使用来自个体的个体血清的个体抗体制备物筛选所鉴定的抗原,该个体含有针对所述特异性病原体的抗体。
-鉴定所述已鉴定出的抗原的超免疫血清反应性抗原部分,且该超免疫血清反应性抗原结合源自个体血清的个体抗体制备物的相关部分,
-重复所述筛选和鉴定步骤至少一次,
-比较在初始筛选和鉴定步骤中鉴定的超免疫血清反应性抗原和在重复的筛选及鉴定步骤中鉴定的超免疫血清反应性抗原,
-如果仅在重复的筛选及鉴别步骤中就鉴别出大于5%的超免疫血清反应性抗原,则继续重复筛选及鉴别步骤直到仅在重复的筛选及鉴别步骤中鉴别出的超免疫血清反应性抗原小于5%为止,这样得到针对某种病原体的全套超免疫血清反应性抗原;以及
-可选分离所述超免疫血清反应性抗原,并通过化学或重组方法生产所述超免疫血清反应性抗原。
3.根据权利要求1或2的方法,其特征在于至少一种所述表达文库选自核糖体展示文库、菌体表面展示文库和蛋白质组。
4.根据权利要求2的方法,其特征在于至少3种不同的表达文库是至少核糖体展示文库、菌体表面展示文库和蛋白质组。
5.根据权利要求1-4中任意一项的方法,其特征在于所述血浆库为人血浆库,取自经历过或正在经历所述病原体感染的个体。
6.根据权利要求1-5中任意一项的方法,其特征在于所述表达文库为所述病原体的基因表组达文库。
7.根据权利要求1-6中任意一项的方法,其特征在于所述表达文库为完全的基因组表达文库,优选具有至少2倍的冗余度,更优选至少5倍,尤其是至少10倍。
8.根据权利要求1-7中任意一项的方法,其特征在于其步骤包含用所述抗体制备物筛选核糖体展示文库、菌体表面展示文库和蛋白质组并鉴定其中在至少二个或全部筛选中与所述抗体制备物中的抗体结合的抗原。
9.根据权利要求1-8中任意一项的方法,其特征在于所述病原体选自细菌、病毒、真菌、原生动物病原体。
10.根据权利要求1-9中任意一项的方法,其特征在于所述病原体选自人免疫妥协病毒、甲肝病毒、乙肝病毒、丙肝病毒、劳氏肉瘤病毒、非洲淋巴细胞瘤病毒、流感病毒、轮状病毒、金黄色葡萄球菌、表皮葡萄球菌、衣原体肺炎、衣原体沙眼、肺结核分支杆菌、麻风分支杆菌、肺炎链球菌、酿脓链球菌、无乳链球菌、粪肠球菌、炭疽芽孢杆菌、霍乱弧菌、布氏疏螺旋体、疟原虫属、曲霉菌属、白色假丝酵母。
11.根据权利要求1-10中任意一项的方法,其特征在于至少一种所述表达文库是核糖体展示文库或菌体表面展示文库,且所述超免疫血清反应性抗原由所述文库中包含的所述超免疫血清反应性抗原的编码序列表达生成。
12.根据权利要求1-11中任意一项的方法,其特征在于所述生产的超免疫血清反应性抗原最终制成药物制剂,可选加入药学可接受的载体和/或赋形剂。
13.根据权利要求12的方法,其特征在于所述药物制剂是疫苗。
14.根据权利要求12或13的方法,其特征在于那些药学可接受的载体和赋形剂是免疫刺激性化合物。
15.根据权利要求14的方法,其特征在于所述免疫刺激性化合物选自聚阳离子物质,特别是聚阳离子多肽、免疫刺激性脱氧核苷酸、明矾(alumn)、弗氏完全或不完全佐剂、刺激神经组织的化合物,特别是人生长因子,或其组合。
16.根据权利要求1-15中任意一项的方法,其特征在于所述个体抗体制备物源自由所述病原体急性感染的患者,特别是源自那些具有针对该病原的抗体效价高于80%,优选高于90%、尤其高于95%所测试的患者或携带者血清的患者。
17.根据权利要求1-16中任意一项的方法,其特征在于使用至少10种、优选至少30种、尤其是至少50种个体抗体制备物来鉴定所述超免疫血清反应性抗原。
18.根据权利要求1-17中任意一项的方法,其特征在于来自个体血清的所述个体抗体制备物的相关部分是至少10种、优选至少30种、甚至至少50种抗体制备物,和/或在所述筛选中使用的所有抗体制备物的至少20%、优选至少30%、尤其是至少40%。
19.根据权利要求1-18中任意一项的方法,其特征在于所述个体血清通过具有抗特定病原体的溶菌液、细胞壁组分或重组蛋白的IgA效价高于4000U,尤其是高于6000U,和/或IgG效价高于10000U、优选高于12000U而选择。
20.根据权利要求1-19中任意一项的方法,其特征在于所述抗原为葡萄球菌抗原,尤其是金黄色葡萄球菌和表皮葡萄球菌的抗原。
21.超免疫血清反应性抗原,选自表2a,2b,2c,2d,3,4和5任一中所列的序列,特别选自以下序列及其超免疫片段:Seq.IDNo.56,57,59,60,67,70,72,73,74,75,76,77,78,79,80,81,82,85,87,88,89,90,92,95,96,97,99,100,101,102,103,104,106,108,110,112,114,116,118,120,122,126,128,130,132,134,138,140,142,151,152,154,155。
22.根据权利要求1-20任一的方法得到的超免疫血清反应性抗原,且选自表2a,2b,2c,2d,3,4和5任一中所列的序列,特别选自以下序列及其超免疫片段:Seq.ID No.56,57,59,60,67,70,72,73,74,75,76,77,78,79,80,81,82,85,87,88,89,90,92,95,96,97,99,100,101,102,103,104,106,108,110,112,114,116,118,120,122,126,128,130,132,134,138,140,142,151,152,154,155。
23.超免疫血清反应性抗原用于生产药物制剂,特别是生产抗葡萄球菌感染或菌落化,尤其是抗金黄色葡萄球菌或表皮葡萄球菌的疫苗中的用途,该超免疫血清反应性抗原选自表2a,2b,2c,2d,3,4和5任一中所列序列,特别选自以下序列和其超免疫片段:Seq.IDNo.55,56,57,58,59,60,62,66,67,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,87,88,89,90,92,94,95,96,97,99,100,101,102,103,104,106,108,110,112,114,116,118,120,122,126,128,130,132,134,138,140,142,151,152,154,155,158。
24.超免疫血清反应性抗原的超免疫片段,该抗原选自包含表2a,2b,2c,和2d的“预测的免疫原性氨基酸”、“鉴定的免疫原性区域的位置”、“同相关区域的血清反应性”栏中的氨基酸序列和表4和5的“推定的抗原性表面区域”栏中的氨基酸序列的肽,特别是包含下列氨基酸序列的肽,及其描述于表2和表4的片段和包含所述序列至少6个,优选大于8个,尤其大于10个氨基酸的片段:
No.aa 12-29,34-40,63-71,101-110,114-122,130-138,140-195,197-209,215-229,239-253,255-274和39-94在Seq.ID No.55,中
aa 5-39,111-117,125-132,134-141,167-191,196-202,214-232,236-241,244-249,292-297,319-328,336-341,365-380,385-391,407-416,420-429,435-441,452-461,477-488,491-498,518-532,545-556,569-576,581-587,595-602,604-609,617-640,643-651,702-715,723-731,786-793,805-811,826-839,874-889,37-49,63-77和274-334,在Seq.ID No.56,中
aa 28-55,82-100,105-111,125-131,137-143,1-49,在Seq.ID No.57,中
aa 33-43,45-51,57-63,65-72,80-96,99-110,123-129,161-171,173-179,185-191,193-200,208-224,227-246,252-258,294-308,321-329,344-352,691-707,358-411和588-606,在Seq.ID No.58,中
aa 16-38,71-77,87-94,105-112,124-144,158-164,169-177,180-186,194-204,221-228,236-245,250-267,336-343,363-378,385-394,406-412,423-440,443-449,401-494,在Seq.ID No.59,中
aa 18-23,42-55,69-77,85-98,129-136,182-188,214-220,229-235,242-248,251-258,281-292,309-316,333-343,348-354,361-367,393-407,441-447,481-488,493-505,510-515,517-527,530-535,540-549,564-583,593-599,608-621,636-645,656-670,674-687,697-708,726-734,755-760,765-772,785-792,798-815,819-824,826-838,846-852, 889-904,907-913,932-939,956-964,982-1000,1008-1015,1017-1024,1028-1034,1059-1065,1078-1084,1122-1129,1134-1143,1180-1186,1188-1194,1205-1215,1224-1230,1276-1283,1333-1339,1377-1382,1415-1421,1448-1459,1467-1472,1537-1545,1556-1566,1647-1654,1666-1675,1683-1689,1722-1737,1740-1754,1756-1762,1764-1773,1775-1783,1800-1809,1811-1819,1839-1851,1859-1866,1876-1882,1930-1939,1947-1954,1978-1985,1999-2007,2015-2029,2080-2086,2094-2100,2112-2118,2196-2205,2232-2243,198-258,646-727和2104-2206,在Seq.ID No.60,中aa 10-29,46-56,63-74,83-105,107-114,138-145,170-184,186-193,216-221,242-248,277-289,303-311,346-360,379-389,422-428,446-453,459-469,479-489,496-501,83-156,在Seq.ID No.62,中
aa 14-22,32-40,52-58,61-77,81-93,111-117,124-138,151-190,193-214,224-244,253-277,287-295,307-324,326-332,348-355,357-362,384-394,397-434,437-460,489-496,503-510,516-522,528-539,541-547,552-558,563-573,589-595,602-624,626-632,651-667,673-689,694-706,712-739,756-790,403-462,在Seq.IDNo.66,中
aa 49-56,62-68,83-89,92-98,109-115,124-131,142-159,161-167,169-175,177-188,196-224,230-243,246-252,34-46,在Seq.ID No.67,中
aa 11-20,26-47,69-75,84-92,102-109,119-136,139-147,160-170,178-185,190-196,208-215,225-233,245-250,265-272,277-284,300-306,346-357,373-379,384-390,429-435,471-481,502-507,536-561,663-688,791-816,905-910,919-933,977-985,1001-1010,1052-1057,1070-1077,1082-1087,1094-1112,493-587,633-715和704-760,在Seq.ID No.70,中
aa.6-20,53-63,83-90,135-146,195-208,244-259,263-314,319-327,337-349,353-362,365-374,380-390,397-405,407-415,208-287和286-314,在Seq.ID No.71,中
aa 10-26,31-43,46-58,61-66,69-79,85-92,100-115,120-126,128-135,149-155,167-173,178-187,189-196,202-222,225-231,233-240,245-251,257-263,271-292,314-322,325-334,339-345,59-74,在Seq.ID No.72,中
aa 4-9,15-26,65-76,108-115,119-128,144-153,38-52和66-114,在Seq.ID No.73,中
aa 5-22,42-50,74-81,139-145,167-178,220-230,246-253,255-264,137-237和250-267,在Seq.ID No.74,中
aa 10-26,31-44,60-66,99-104,146-153,163-169,197-205,216-223,226-238,241-258,271-280,295-315,346-351,371-385,396-407,440-446,452-457,460-466,492-510,537-543,546-551,565-582,590-595,635-650,672-678,686-701,705-712,714-721,725-731,762-768,800-805,672-727,在Seq.ID No.75,中
aa 5-32,35-48,55-76,在Seq.ID No.76,中
aa 7-35,54-59,247-261,263-272,302-320,330-339,368-374,382-411,126-143和168-186,在Seq.ID No.77,中
aa 5-24,88-94,102-113,132-143,163-173,216-224,254-269,273-278,305-313,321-327,334-341,31-61和58-74,在Seq.ID No.78,中
aa 16-24,32-39,43-49,64-71,93-99,126-141,144-156,210-218,226-233,265-273,276-284,158-220,在Seq.ID No.79,中
aa 49-72,76-83,95-105,135-146,148-164,183-205,57-128,在Seq.ID No.80,中
aa 6-15,22-32,58-73,82-88,97-109,120-131,134-140,151-163,179-185,219-230,242-255,271-277,288-293,305-319,345-356,368-381,397-406,408-420,427-437,448-454,473-482,498-505,529-535,550-563,573-580,582-590,600-605,618-627,677-685,718-725,729-735,744-759,773-784,789-794,820-837,902-908,916-921,929-935,949-955,1001-1008,1026-1032,1074-1083,1088-1094,1108-1117,1137-1142,1159-1177,1183-1194,1214-1220,1236-1252,1261-1269,1289-1294,1311-1329,1336-1341,1406-1413,1419-1432,1437-1457,1464-1503,1519-1525,1531-1537,1539-1557,1560-1567,1611-1618,1620-1629,1697-1704,1712-1719,1726-1736,1781-1786,1797-1817,1848-1854,1879-1890,1919-1925,1946-1953,1974-1979,5 to 134,在Seq.ID No.81,中
aa 6-33,40-46,51-59,61-77,84-104,112-118,124-187,194-248,252-296,308-325,327-361,367-393,396-437,452-479,484-520,535-545,558-574,582-614,627-633,656-663,671-678,698-704,713-722,725-742,744-755,770-784,786-800,816-822,827-837,483-511,在Seq.ID No.82,中
aa 4-19,57-70,79-88,126-132,144-159,161-167,180-198,200-212,233-240,248-255,276-286,298-304,309-323,332-346,357-366,374-391,394-406,450-456,466-473,479-487,498-505,507-519,521-530,532-540,555-565,571-581,600-611,619-625,634-642,650-656,658-665,676-682,690-699,724-733,740-771,774-784,791-797,808-815,821-828,832-838,876-881,893-906,922-929,938-943,948-953,969-976,1002-1008,1015-1035,1056-1069,1105-1116,1124-1135,1144-1151,1173-1181,1186-1191,1206-1215,1225-1230,1235-1242,6-66,65-124和590-604,在Seq.ID No.83,中
aa 5-32,66-72,87-98,104-112,116-124,128-137,162-168,174-183,248-254,261-266,289-303,312-331,174-249,在Seq.ID No.84,中
aa 4-21,28-40,45-52,59-71,92-107,123-137,159-174,190-202,220-229,232-241,282-296,302-308,312-331,21-118,在Seq.IDNo.85,中
aa 9-28,43-48,56-75,109-126,128-141,143-162,164-195,197-216,234-242,244-251,168-181,在Seq.ID No.87,中
aa 4-10,20-42,50-86,88-98,102-171,176-182,189-221,223-244,246-268,276-284,296-329,112-188,在Seq.ID No.88,中aa 4-9,13-24,26-34,37-43,45-51,59-73,90-96,99-113,160-173,178-184,218-228,233-238,255-262,45-105,103-166和66-153,在Seq.ID No.89,中
aa 13-27,42-63,107-191,198-215,218-225,233-250,474-367,在Seq.ID No.90,中
aa 26-53,95-123,164-176,189-199,8-48,在Seq.ID No.92,中aa 7-13,15-23,26-33,68-81,84-90,106-117,129-137,140-159,165-172,177-230,234-240,258-278,295-319,22-56,23-99,97-115,233-250和245-265,在Seq.ID No.94,中
aa 13-36,40-49,111-118,134-140,159-164,173-183,208-220,232-241,245-254,262-271,280-286,295-301,303-310,319-324,332-339,1-85,54-121和103-185,在Seq.ID No.95,中
aa 39-44,46-80,92-98,105-113,118-123,133-165,176-208,226-238,240-255,279-285,298-330,338-345,350-357,365-372,397-402,409-415,465-473,488-515,517-535,542-550,554-590,593-601,603-620,627-653,660-665,674-687,698-718,726-739,386-402,在Seq.ID No.96,中
aa 5-32,34-49,1-43,在Seq.ID No.97,中
aa 10-27,37-56,64-99,106-119,121-136,139-145,148-178,190-216,225-249,251-276,292-297,312-321,332-399,403-458,183-200,在Seq.ID No.99,中
aa 5-12,15-20,43-49,94-106,110-116,119-128,153-163,175-180,185-191,198-209,244-252,254-264,266-273,280-288,290-297,63-126,在Seq.ID No.100,中
aa 5-44,47-55,62-68,70-78,93-100,128-151,166-171,176-308,1-59,在Seq.ID No.101,中
aa 18-28,36-49,56-62,67-84,86-95,102-153,180-195,198-218,254-280,284-296,301-325,327-348,353-390,397-402,407-414,431-455,328-394,在Seq.ID No.102,中
aa 7-37,56-71,74-150,155-162,183-203,211-222,224-234,242-272,77-128,在Seq.ID No.103,中
aa 34-58,63-69,74-86,92-101,130-138,142-150,158-191,199-207,210-221,234-249,252-271,5-48,在Seq.ID No.104,中
aa 12-36,43-50,58-65,73-78,80-87,108-139,147-153,159-172,190-203,211-216,224-232,234-246,256-261,273-279,286-293,299-306,340-346,354-366,167-181,在Seq.ID No.106,中
aa 61-75,82-87,97-104,113-123,128-133,203-216,224-229,236-246,251-258,271-286,288-294,301-310,316-329,337-346,348-371,394-406,418-435,440-452在Seq.ID No.112,中
aa 30-37,44-55,83-91,101-118,121-128,136-149,175-183,185-193,206-212,222-229,235-242在Seq.ID No.114,中
aa 28-38,76-91,102-109,118-141,146-153,155-161,165-179,186-202,215-221,234-249,262-269,276-282,289-302,306-314,321-326,338-345,360-369,385-391在Seq.ID No.116,中
aa 9-33,56-62,75-84,99-105,122-127,163-180,186-192,206-228,233-240,254-262,275-283,289-296,322-330,348-355,416-424,426-438,441-452,484-491,522-528,541-549,563-569,578-584,624-641,527-544,在Seq.ID No.142,中
aa 37-42,57-62,121-135,139-145,183-190,204-212,220-227,242-248,278-288,295-30,304-309,335-341,396-404,412-433,443-449,497-503,505-513,539-545,552-558,601-617,629-649,702-711,736-745,793-804,814-829,843-858,864-885,889-895,905-913,919-929,937-943,957-965,970-986,990-1030,1038-1049,1063-1072,1080-1091,1093-1116,1126-1136,1145-1157,1163-1171,1177-1183,1189-1196,1211-1218,1225-1235,1242-1256,1261-1269,624-684,在Seq.ID No.151,中
aa 8-23,31-38,42-49,61-77,83-90,99-108,110-119,140-147,149-155,159-171,180-185,189-209,228-234,245-262,264-275,280-302,304-330,343-360,391-409,432-437,454-463,467-474,478-485,515-528,532-539,553-567,569-581,586-592,605-612,627-635,639-656,671-682,700-714,731-747,754-770,775-791,797-834,838-848,872-891,927-933,935-942,948-968,976-986,1000-1007,1029-1037,630-700,在Seq.ID No.152,中
aa 17-25,27-55,84-90,95-101,115-121,55-101,在Seq.ID No.154,中
aa 13-28,40-46,69-75,86-92,114-120,126-137,155-172,182-193,199-206,213-221,232-238,243-253,270-276,284-290,22-100,在Seq.ID No.155中和
aa 7-19,46-57,85-91,110-117,125-133,140-149,156-163,198-204,236-251,269-275,283-290,318-323,347-363,9-42和158-174,在Seq.ID No.158,中
aa 7-14,21-30,34-50,52-63,65-72,77-84,109-124,129-152,158-163,175-190,193-216,219-234在Seq.ID.No.168,中
aa 5-24,38-44,100-106,118-130,144-154,204-210,218-223,228-243,257-264,266-286,292-299在Seq.ID.No.174,中
aa 29-44,74-83,105-113,119-125,130-148,155-175,182-190,198-211,238-245在Seq.ID.No.176,中和
25.如权利要求21-24任一项所限定的抗原或片段的辅助抗原决定部位,特别是肽含有的片段选自表4和5的“推定的抗原表面区域”栏中提到的肽和选自下列氨基酸序列或其作为T细胞抗原决定部位的片段:Seq.ID No.56的氨基酸6-40,583-598,620-646及871-896,Seq.ID No.70的氨基酸24-53,Seq.ID No.74的氨基酸240-260,Seq.ID No.81的氨基酸1660-1682,和1746-1790,Seq.ID No.83的氨基酸1-29,680-709,和878-902,Seq.ID No.89的氨基酸96-136,Seq.ID No.94的氨基酸1-29,226-269,和275-326,Seq.ID No.114的氨基酸23-47和107-156,和Seq.ID No.142的氨基酸24-53。
26.含有如权利要求21-25任一项所限定的超免疫血清反应性抗原或其片段的疫苗。
27.根据权利要求26的疫苗,其特征在于该疫苗进一步包含免疫刺激性化合物,优选选自聚阳离子聚合物,特别是聚阳离子肽、免疫刺激性脱氧核苷酸(ODN)、刺激神经组织的化合物,特别是人生长因子,明矾、弗氏完全佐剂或不完全佐剂或其组合。
28.包含抗至少一种如权利要求21-25任一项所限定的抗原或其片段的抗体的制剂。
29.根据权利要求27的制剂,其特征在于所述抗体为单克隆抗体。
30.生产根据权利要求28的制剂的方法,其特征在于下列步骤:
-通过对非人属动物施用如权利要求21-25任一项所限定的抗原或其片段在所述动物中引起免疫反应,
-从所述动物取出脾或脾细胞,
-生产该脾或脾细胞的杂交瘤细胞,
-筛选并克隆对所述抗原特异的杂交瘤细胞,以及
-通过培养所述克隆的杂交瘤和可选进一步纯化来制备该抗体制备物。
31.根据权利要求29的方法,其特征在于摘取脾或脾细胞与杀死该动物相关。
32.生产根据权利要求27的制剂的方法,其特征在于下列步骤:
-通过对非人属动物施用如权利要求21-25任一项所限定的抗原或其片段在所述动物中引起免疫反应,
-从所述动物中取出含有抗体的体液,
-将含有抗体的体液进一步纯化,产生该抗体制备物。
33.根据权利要求27或28的制剂在生产用于治疗或预防葡萄球菌感染或菌落化的药物中的用途,特别针对金黄色葡萄球菌或表皮葡萄球菌。
34.评价至少一种如在权利要求21-25任一中所限定的抗原或其片段的功能性抑制的效果的筛选方法。
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ATA130/2001 | 2001-01-26 | ||
AT0013001A AT410798B (de) | 2001-01-26 | 2001-01-26 | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
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KR (4) | KR20080107477A (zh) |
CN (2) | CN101492496A (zh) |
AT (2) | AT410798B (zh) |
AU (3) | AU2002247641B8 (zh) |
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