KR20080107477A - 특이적 병원균에 대한 항원을 동정하고 분리하여 생산하는 방법 - Google Patents
특이적 병원균에 대한 항원을 동정하고 분리하여 생산하는 방법 Download PDFInfo
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- KR20080107477A KR20080107477A KR1020087026439A KR20087026439A KR20080107477A KR 20080107477 A KR20080107477 A KR 20080107477A KR 1020087026439 A KR1020087026439 A KR 1020087026439A KR 20087026439 A KR20087026439 A KR 20087026439A KR 20080107477 A KR20080107477 A KR 20080107477A
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Abstract
본원 발명에서는 특정 병원균, 종양, 알레르겐, 또는 자가 면역성을 가지기 쉬운 조직이나 숙주로부터 과다면역 혈청-반응성 항원을 동정하고 분리하여 생산하는 방법을 기술하는데, 상기 항원은 인간 또는 일정한 동물에서 백신으로 사용하기에 적합하고, 상기 방법은 아래의 단계로 특성화된다:
- 특정 병원균, 종양, 알레르겐, 또는 자가 면역성을 가지기 쉬운 조직이나 숙주에 대한 항체를 포함하는 동물 혈장액, 또는 인간 혈장액 또는 개별 혈청으로부터 항체 조제물을 제공하는 단계;
- 특정 병원균, 종양, 알레르겐, 또는 자가 면역성을 가지기 쉬운 조직이나 숙주의 최소한 1가지 발현 라이브러리를 제공하는 단계;
- 항체 조제물을 이용하여 최소한 1가지 발현 라이브러리를 선별하는 단계;
- 선별 과정에서 항체 조제물 내에 항체에 결합하는 항원을 확인하는 단계;
- 확인된 항원을 특정 병원균, 종양, 알레르겐, 또는 자가 면역성을 가지기 쉬운 조직이나 숙주에 대한 항체를 포함하는 개체의 개별 혈청으로부터 유래된 개별 항체 조제물로 선별하는 단계;
- 확인된 항원의 과다면역 혈청-반응성 항원 부분을 확인하고, 이때 과다면역 혈청-반응성 항원은 개별 혈청으로부터 유래된 개별 항체 조제물의 관련 부분에 결합하는 단계;
- 과다면역 혈청-반응성 항원을 선택적으로 분리하고, 화학적 또는 재조합 방법을 이용하여 과다면역 혈청-반응성 항원을 생산하는 단계.
과다면역 혈청-반응성 항원
Description
본원 발명은 특이적 병원균에 대한 항원을 동정하고 분리하여 생산하는 방법 및 일정한 동물이나 인체에서 백신으로 사용하는데 적합한 신규한 항원에 관한다.
백신은 어떤 다른 의학적 개입보다 더 많은 생명(및 자원)을 구할 수 있다. 세계적인 백신 프로그램으로 인하여 많은 치명적 질환의 발병률이 현저하게 감소하였다. 이런 견해는 광범위한 질환, 예를 들면, 디프테리아, 백일해, 홍역, 파상풍에도 적용되지만, HIV, HCV, CMV 등과 같은 대부분의 바이러스 감염을 비롯한 다수의 감염성 질환에 대한 효과적인 백신은 존재하지 않는다. 말라리아 또는 암을 비롯한 연간 수백만명의 생명을 앗아가는 다른 감염성 또는 비-감염성 질환에 대한 효과적인 백신 역시 존재하지 않고 있다. 이에 더하여, 항생제-저항성 박테리아와 미생물의 급격한 출현은 백신이 논리적으로 선택되는 대안적 치료법을 요구하고 있다. 최종적으로, 백신에 대한 필요성은 심혈관 질환, 암 또는 외상보다는 감염성 질환이 여전히 전세계적으로 사망과 장애의 최대 원인이라는 사실에 의해서도 뒷받 침된다.
몇몇 기존 백신은 살아있는 약독화된 미생물로 구성되는데, 이런 경우에 유독성의 야생형 균주로 반전될 위험이 존재한다. 특히, 면역약화된 숙주에서 이는 생명을 위협할 수도 있다. 대안으로, 백신은 병원균-유래된 항원 및 이들 항원에 대한 면역 반응을 유도 또는 강화하는 화합물(이들 화합물은 일반적으로 어쥬번트라고 한다)과의 조합으로 투여되는데, 그 이유는 이들 아단위 백신이 단독으로는 효과적이지 못하기 때문이다.
의심할 여지없이 상기 백신들이 귀중한 치료 방법이긴 하지만, 이들의 복합성으로 인하여, 예방접종된 개체의 세포에 의해 발현되는 분자와 교차-반응성을 보이는 백신에 포함되는 항원에 대한 부작용이 초래될 수 있다. 이에 더하여, 백신 조성물의 정확한 규격 및 면역 도입 기전에 대한 통제 당국, 예를 들면, 세계 보건 기구(WHO), 식품의약국(FDA), 이들에 대응하는 유럽 기구의 요구사항은 충족하기 쉽지 않다.
광범위하게 사용되는 백신은 전체 세포-백신, 예를 들면, 약독화된 박테리아나 바이러스(예, Bacille Calmette-Guerin(BCG)(결핵), 홍역, 이하선염, 풍진, 경구 폴리오 백신(Sabin)), 사멸된 박테리아나 바이러스(예, 백일해, 불활화된 폴리오 백신(Salk)), 아단위-백신(예, 변성 독소(디프테리아, 파상풍)), 협막 폴리사카라이드(H. 인플루엔자 B형), 효모 재조합 아단위(B형 간염 표면 단백질)이다.
백신은 전혀 상이한 항원을 함유할 수 있다. 항원의 예는 완전히 죽은 생물, 예를 들면, 불활화된 바이러스나 박테리아, 곰팡이, 원생동물 또는 암세포이다. 항 원은 이들 생물/조직 또는 단백질(또는 가장 단순한 형태의 단백질) 소분획물(subfraction)로 구성될 수도 있다. 항원은 당화된 단백질 또는 펩티드 형태로 면역계에 의해 인식될 수 있고 폴리사카라이드 또는 지질 자체이거나 이들을 보유할 수도 있다. 예로써, 세포독성 T 세포(CTL)가 주조직접합성 복합체(MHC)와 결합된 일반적으로 짧은 8-11 아미노산 길이의 펩티드를 인식한다는 점에서 짧은 펩티드를 사용할 수 있다. B 세포는 4-5개 아미노산의 짧은 선형 에피토프 및 3차원적 구조(입체형태적 에피토프)를 인식할 수 있다. 지속적인 항원-특이적 면역 반응을 얻기 위하여, 필요한 면역계의 모든 세포가 포함되는 면역 캐스케이드를 유인하는 데에는 어쥬번트가 효과적이다. 기본적으로, 어쥬번트는 항원 제시 세포(APC)에 작용한다. 이들 세포는 먼저 항원과 직면하고, 이후 가공된 또는 변형된 항원을 면역 주효체에 제시한다. 중간단계 세포형이 참여할 수도 있다. 적절한 특이성을 갖는 주효체 세포만이 생산적 면역 반응에서 활성화된다. 어쥬번트는 또한 항원과 동시-주입된 다른 인자를 국소적으로 보유할 수도 있다. 이에 더하여, 어쥬번트는 다른 면역세포에 대한 유인물질로 작용하거나 또는 면역계에 대한 촉진물질로서 국소적으로 및/또는 전신적으로 작용할 수 있다.
항원 제시 세포는 선천성 면역계(innate immune system)에 속하는데, 이는 미생물에 대한 노출직후에 감염을 제한하는 제 1 숙주 방어선으로 진화하였다. 선천성 면역계 세포는 적응성 면역계(adaptive immune system)에 의해 인식되는 더욱 정교하고 특이적인 구조보다는 오히려 표적에서 발현되는 패턴 또는 상대적으로 비-특이적인 구조를 인식한다. 선천성 면역계 세포의 예는 대식세포, 수상돌기 세포, 과립백혈구(예, 호중구), 고유 살해 세포 등이다. 대조적으로, 적응성 면역계 세포는 T 세포의 경우에 펩티드를 비롯한 특이적인 항원 구조 및 B 세포의 경우에 펩티드와 3차원 구조를 인식한다. 적응성 면역계는 선천성 면역계보다 훨씬 더 특이적이고 정교하며, 임의의 병원균/항원에 반복적으로 노출될 때에 증대된다. 계통발생학적으로, 선천성 면역계는 훨씬 오래되었고 매우 원시적인 생물에서도 발견할 수 있다. 그럼에도 불구하고, 선천성 면역계는 초기 단계의 항원 노출동안 중요한데, 그 이유는 병원균의 억제이외에 선천성 면역계 세포(즉, APC)가 적응성 면역계 세포를 기폭하고 침입자의 제거로 귀결되는 특이적인 면역 반응을 유인하기 때문이다. 요약하면, 선천성 면역계 세포 및 특히 APC는 a) 원시적인 패턴 인식 시스템으로 감염을 억제하고 b) 적응성 면역계 세포를 기폭하여 침입 병원균 또는 다른 표적의 소거를 결과하는 특이적 면역 반응과 기억을 유도함으로써 초기 단계 면역 반응 동안 중요한 역할을 수행한다(Roitt et al., 1998). 이들 기전은 종양 세포를 소거 또는 억제하는 데에도 중요하다.
이런 백신에 사용되는 항원은 무작위 또는 입수가능성의 용이함으로 종종 선택된다. 일정한 병원균에 효과적인 항원 또는 바람직하게는, 실질적으로(임상적으로) 적합한 병원균의 거의 모든 항원 세트를 확인하는 것이 요구된다. 이런 항원은 백신에 바람직한 항원 후보일 수 있다.
따라서, 본원 발명의 목적은 이들 요구를 충족시키고, 이런 항원을 제공하고 예로써, 일정한 병원균의 실질적으로 모든 항원 세트를 일정한 혈청을 항체원으로 하여 확인할 수 있는 방법을 제시하는 것이다. 이런 방법은 일반적인 약물이나 백신에 대한 저항성을 신속하게 발전시키는 급속하게 변하는 병원균에도 적합할 수 있다. 상기 방법은 종양 항원, 알레르겐, 또는 자가면역 항원을 확인하는데 이용될 수 있다.
따라서, 본원 발명은 특정 병원균, 종양, 알레르겐, 또는 자가 면역성을 가지기 쉬운 조직이나 숙주, 특히, 특정 병원균으로부터 과다면역 혈청-반응성 항원을 동정하고 분리하여 생산하는 방법을 제시하는데, 상기 항원은 특정한 동물이나 인간에서 백신으로 사용하는데 적합하고, 상기 방법은 다음의 단계로 특성화된다:
- 특정 병원균, 종양, 알레르겐, 또는 자가 면역성을 가지기 쉬운 조직이나 숙주에 대한 항체를 포함하는 동물 혈장액, 또는 인간 혈장액 또는 개별 혈청으로부터 항체 조제물을 제공하는 단계;
- 특정 병원균, 종양, 알레르겐, 또는 자가 면역성을 가지기 쉬운 조직이나 숙주의 최소한 1가지 발현 라이브러리를 제공하는 단계;
- 항체 조제물을 이용하여 최소한 1가지 발현 라이브러리를 선별하는 단계;
- 선별 과정에서 항체 조제물 내에 항체에 결합하는 항원을 확인하는 단계;
- 확인된 항원을 특정 병원균, 종양, 알레르겐, 또는 자가 면역성을 가지기 쉬운 조직이나 숙주에 대한 항체를 포함하는 개체의 개별 혈청으로부터 유래된 개별 항체 조제물로 선별하는 단계;
- 확인된 항원의 과다면역 혈청-반응성 항원 부분을 확인하고, 이때 과다면역 혈청-반응성 항원은 개별 혈청으로부터 유래된 개별 항체 조제물의 관련 부분에 결합하는 단계;
- 과다면역 혈청-반응성 항원을 선택적으로 분리하고, 화학적 또는 재조합 방법을 이용하여 과다면역 혈청-반응성 항원을 생산하는 단계.
상기 방법은 최소한 3가지의 상이한 발현 라이브러리가 본원 발명에 따른 방법을 이용한 병원균/항원 동정 프로그램으로 선별되면, 일정한 혈청을 항체원으로 하여 실질적으로 완전한 세트의 과다면역 혈청-반응성 항원을 확인하는 데에도 적합하다. 따라서, 본원 발명은 특정 병원균의 실질적으로 완전한 세트의 과다면역 혈청-반응성 항원을 동정하고 분리하여 생산하는 방법에 관하는데, 상기 항원은 특정한 동물이나 인간에서 백신으로 사용하기에 적합하고, 상기 방법은 다음의 단계로 특성화된다:
- 특정 병원균에 대한 항체를 포함하는 동물 혈장액, 또는 인간 혈장액 또는 개별 혈청으로부터 항체 조제물을 제공하는 단계;
- 특정 병원균의 최소한 3가지 상이한 발현 라이브러리를 제공하는 단계;
- 항체 조제물을 이용하여 최소한 3가지 상이한 발현 라이브러리를 선별하는 단계;
- 최소한 3가지 선별 과정 중에서 적어도 하나에서, 항체 조제물 내에 항체 에 결합하는 항원을 확인하는 단계;
- 확인된 항원을 특정 병원균에 대한 항체를 포함하는 개체로부터 개별 혈청으로부터 유래된 개별 항체 조제물로 선별하는 단계;
- 확인된 항원의 과다면역 혈청-반응성 항원 부분을 확인하고, 이때 과다면역 혈청-반응성 항원은 개별 혈청으로부터 유래된 개별 항체 조제물의 관련 부분에 결합하는 단계;
- 최소한 한번은 선별과 확인 단계를 반복하는 단계;
- 반복된 선별과 확인 단계에서 확인된 과다면역 혈청 반응성 항원과 최초 선별과 확인 단계에서 확인된 과다면역 혈청-반응성 항원을 비교하는 단계;
- 반복된 선별과 확인 단계에서 최소한 5%의 과다면역 혈청-반응성 항원이 확인되면, 추가의 반복 단계에서 5% 미만의 과다면역 혈청-반응성 항원이 확인될 때까지 선별과 확인 단계를 더욱 반복하여 특정 병원균의 과다면역 혈청-반응성 항원의 완전한 세트를 수득하는 단계;
- 과다면역 혈청-반응성 항원을 선택적으로 분리하고, 화학적 또는 재조합 방법을 이용하여 과다면역 혈청-반응성 항원을 생산하는 단계.
본원 발명에 따른 방법은 3가지 필수 단계, 다시 말하면, 1. 일정한 병원균에 특이적인 항원을 포함하는 과다면역 혈청원의 확인; 2. 후보 항원(또는 이런 항원의 항원성 단편)이 선별되는 적절한 항체 조제물로 적합한 발현 라이브러리의 선별; 3. 개인 항체로부터 유래된 개별 항체 조제물 일부에 결합하는 능력으로 과다면역 혈청-반응성 항원을 확인하는 2차 선별, 여기서 이들 항원은 실질적으로 유관 하고 과다면역 혈청-반응성뿐만 아니라 광범위한 면역원성(즉, 다수의 개별 항체가 항원과 반응한다)을 나타낸다. 본원 발명의 방법으로, 선택된 병원 및 선택된 혈청과 실질적으로 경쟁하는 병원균의 일단의 항원을 제시하는 것이 가능하다. 따라서, 본원 발명에서는 병원균의 “잘못된” 항원 후보 또는 불완전한 일단의 항원과 관련된 선입견이 배제된다.
본원 발명에서 병원균의 항원 세트의 완전성은 라이브러리의 대표성 및 발현 시스템의 유용성과 관련하여, 본원 발명에 이용되는 발현 라이브러리의 완전성 및 검사된 혈청 수집물(다수의 개별 혈장/혈청)의 품질과 크기에 좌우된다. 따라서, 본원 방법의 적절한 구체예에서 상기 발현 라이브러리중 적어도 한 가지는 리보솜 전시 라이브러리, 박테리아 표면 라이브러리, 프로테옴에서 선택된다.
본원 발명에 사용되는 혈청 수집물은 일정한 병원균의 공지된 항원성 화합물 패널, 예를 들면, 세포벽, 세포막, 세포질의 폴리사카라이드, 지질, 단백질성 구성요소 및 분비된 산물에 대하여 검사한다. 적절하게는, 3가지의 상이한 혈청 수집물이 이용된다: 1. 매우 안정한 항체 레퍼토리: 급성 질환이나 증상 없이 일정한 병원균의 사전 조우 또는 현재의 보균을 극복하는 정상적인 성인, 임상적으로 건강한 사람; 2. 병원성 미생물의 존재에 의해 실제로 유도된 항체: 상이한 증상의 급성 질환을 보이는 환자; 3. 특이적인 항체 없음(네거티브 대조): 출생 5-6개월후 모체로부터 전달된 면역글로불린을 상실한 5-8개월된 아기. 혈청은 일정한 병원균(박테리아, 진균, 기생충 등) 및 본원 발명에 다른 선별 방법에 적합한 병원균에 대한 과다면역을 고려하기 위하여 다중의 병원균-특이적 항원과 반응해야 한다.
본원 발명에 따른 완전한 항원 세트를 확인하기 위한 항원 동정 프로그램에서, 적어도 3가지의 상이한 발현 라이브러리는 적어도 한가지의 리보솜 전시 라이브러리, 박테리아 표면 라이브러리, 프로테옴이어야 한다. 모든 발현 라이브러리가 완전할 수 있지만, 상이한 발현 라이브러리 각각의 선택적 발현 특성으로 인하여 항원 동정 프로그램에서 한두 개의 발현 라이브러리가 완전한 항원 세트를 결과할 수는 없다. 따라서, 한두 개의 상이한 발현 라이브러리로 과다면역 혈청-반응성항원을 수득하는 것이 가능하긴 하지만, 이는 많은 경우에 완전한 세트의 과다면역 혈청-반응성 항원의 동정을 결과하지 못한다. 본원 발명에서 “완전한”은 이론적 최대치가 아닌 실질적인 완전성, 다시 말하면, 병원균의 실질적으로 적절한 항원이나 항원 결정기중 적어도 95%가 확인된다는 것을 의미한다. 따라서, 실질적인 적절성(relevance)은 환자 개체군에서 일정한 병원균에 대한 항체의 발생으로 정의된다.
본원 발명에서, 혈청액이나 혈청 분취물 또는 체액을 함유하는 다른 공동 항체는“혈장액”이라 한다.
본원 발명에 사용되는 발현 라이브러리는 모든 잠재적 항원, 예를 들면, 일정한 병원균의 모든 표면 단백질의 발현을 적어도 가능하게 한다. 본원 발명에 따른 발현 라이브러리로 일정한 병원균의 적어도 한가지 세트의 잠재적 항원을 제시하는데, 상기 세트는 바람직하게는, 병원균 게놈(즉, 실시예 2에서 밝힌 게놈 라이브러리)에 의해 인코드되는 (폴리-)펩티드의 완전한 이론적 보체이고 재조합 숙주 (실시예 3) 또는 시험관내(실시예 4)에서 발현된다. 세포외 병원균의 경우에 이런 잠재적 항원 세트는 단백질 조제물, 바람직하게는, 규정된 생리 조건하에서 배양된 병원균으로부터 얻은 상기 병원균의 표면 단백질을 함유하는 단백질 조제물일 수도 있다(실시예 5). 게놈 접근방식이 완전한 세트의 항원을 포함하는 잠재력을 갖고 있긴 하지만, 후자 방식은 자연 상태에서 이들 단백질을 포함하는, 다시 말하면, 예로써, DNA 서열로부터 자명하지 않은 이들 단백질의 번역후 수식 또는 가공된 형태를 포함하는 이점이 있다. 병원균, 종양, 알레르겐, 또는 자가 면역성을 가지기 쉬운 조직이나 숙주로부터 유래된 이들이나 임의의 다른 세트의 잠재적 항원은 이후 “발현 라이브러리”라고 한다. 다양한 종류의 발현 라이브러리가 본원 발명의 과정에 이용될 수 있다. 바람직한 실례는 Ausubel et al., 1994에 제시한다. 특히 바람직하게는, 재조합 형태로 병원균의 유전자 세트의 전시를 대표하는 발현 라이브러리, 예를 들면, 시험관내 번역 기술(예, 리보솜 전시), 원핵 발현 시스템(예, 박테리아 표면 라이브러리) 또는 일정한 생리 상태에서 일정한 병원균의 특이적인 생리 발현 상태를 모방하는 라이브러리이다.
리보솜 전시는 재조합 DNA 기술에서 확립된 방법인데, 상기 방법은 본원 발명의 각 특정 병원균에 적용가능하다(Schaffitzed et al, 1999). 박테리아 표면 전시 라이브러리는 일정한 병원균의 일단(전체)의 발현된 펩티드 서열, 예를 들면, 박테리아 숙주 막에서 선택된 외부막 단백질을 전시하는 박테리아 숙주의 재조합 라이브러리에 의해 대표된다(Georgiou et al., 1997). 외부막 단백질에서 펩티드 또는 단백질 서열의 전시이외에, 다른 박테리아 전시 기술, 예를 들면, 박테리오파 아지 전시 기술 및 외부로 전달된 단백질을 통한 발현 역시 박테리아 표면 발현 라이브러리로 바람직하다(Forrer et al., 1999; Rodi and Makowski, 1993; Georgiou et al., 1997).
본원 발명에 따른 방법에서 1차 선별을 위한 항원 조제물은 일정한 병원균에 대한 항체를 보유하는 임의의 출처로부터 유래될 수 있다. 적절하게는, 혈장액이 항체 조제물의 출처로 사용되면 주어지 병원균으로 감염을 경험했거나 또는 경험하고 있는 공여물질을 포함하는 인간 혈장액이 선별된다. 혈장이나 혈장액의 이런 선별이 예로써, 과다면역글로불린 조제물질의 생산에서 원칙적인 표준 기술이긴 하지만, 놀랍게도 이런 기술은 본원 발명의 적절한 구체예에 도시된 효과를 보인다.
적절하게는, 발현 라이브러리는 일정한 병원균의 게놈 발현 라이브러리, 또는 대안으로 mRNA 라이브러리이다. 이들 게놈이나 mRNA 라이브러리는 바람직하게는, 완전한 게놈이나 mRNA 발현 라이브러리인데, 이런 사실은 이들이 일정한 병원균의 적어도 한가지의 모든 가능한 발현가능 단백질, 펩티드 또는 펩티드 단편을 포함한다는 것을 의미한다. 게놈 발현 라이브러리는 바람직하게는, 적어도 2x, 더욱 바람직하게는, 적어도 5x, 가장 바람직하게는, 적어도 10x의 과잉을 보인다.
적절하게는, 본원 발명에 따른 방법은 항체 조제물로 적어도 한가지 리보솜 전시 라이브러리, 박테리아 표면 전시 라이브러리, 프로테옴을 선별하고, 적어도 2개, 바람직하게는, 전체 선별에서 상기 항체 조제물에서 항체에 결합하는 항원을 확인하는 단계로 구성된다. 이후, 이런 항체는 발현의 방식에 상관없이 과다면역 항원으로 매우 적합한 것으로 간주될 수 있다. 적절하게는, 적어도 2개의 선별은 프로테옴을 적어도 포함하여야 하는데, 그 이유는 프로테옴이 DNA 서열로부터 자명하지 않은 번역후 수식, 가공 등을 포함하는 자연적으로 발현된 단백질로서 항원을 항상 대표하기 때문이다.
본원 발명에 따른 방법은 임의의 일정한 병원균에 적용될 수 있다. 따라서, 바람직한 병원균은 박테리아, 바이러스, 진균, 원생동물 병원균에서 선택된다. 본원 발명에 따른 방법은 암, 다시 말하면, 종양-관련된 항원의 동정 및 자가-면역 질환에 관여하는 알레르겐이나 항원의 동정에도 적용가능하다. 특히, 재조합 방법은 작은 게놈이나 상대적으로 적은 수의 발현된 단백질을 갖는 병원균(예, 박테리아 또는 바이러스 병원균)에서는 상당히 간단하고 대량의 게놈을 갖는 복잡한(진핵) 생물에서는 더욱 복잡하다. 하지만, 고등 생물 병원균의 이런 대규모 게놈 라이브러리는 본원 발명에 따라 적합한 항원을 확인하는 공지된 방법에서보다 더욱 신속하고 신뢰할 수 있는 방식으로 분석될 수 있다.
분석하거나 또는 항원이 추출되는 바람직한 병원균에는 인간 면역결핍 바이러스(HIV), A형 간염 바이러스(HAV), B형 간염 바이러스(HBV), C형 간염 바이러스(HCV), 라우스 육종 바이러스(RSV), 엡스테인 바르 바이러스(EBV), 인플루엔자 바이러스(IV), 로타바이러스(RV), 스타필로코커스 아우레우스(Staphylococcus aureus), 스타필로코커스 에피데르미디스(Staphylococcus epidermidis), 클라미디아 뉴모니아(Chlamydia pneumoniae), 클라미디아 트라코마티스(Chlamydia trachomatis), 미코박테리움 튜베르쿨로시스(Mycobacterium tuberculosis), 미코박테리움 레프라(Mycobacterium leprae), 스트렙토코커스 뉴모니아(Streptococcus pneumoniae), 스트렙토코커스 피오젠(Streptococcus pyogenes), 스트렙토코커스 아갈락티아(Streptococcus agalactiae), 엔테로코커스 페칼리스(Enterococcus faecalis), 바실러스 안트라시스(Bacillus anthracis), 비브리오 콜레라(Vibrio cholerae), 보렐리아 부르그도르페리(Borrelia burgdorferi), 말라리아 종(Plasmodium sp .), 진균 질환(예, 뉴모시스티스 카리니(Pneumocystis carinii)), 아스페르길루스 종(Aspergillus sp .), 크립토코커스 종(Cryptococcus sp .), 칸디다 알비칸스(Candida albicans), 또는 기생충 감염(예, 회충증(Ascaris lumbricoides)과 조충증(Taenia saginata))이 포함된다. 본원 발명에 따른 방법은 박테리아, 기생충 또는 칸디다균에 가장 적합하다.
본원 출원의 모델 미생물로서 스타필로코커스 아우레우스(Staphylococcus aureus)는 본원 발명에 따른 방법의 응용성 및 효율을 입증하기 위하여 선택되었다. 특히 실시예와 관련하여 본원 발명이 모든 잠재적 병원균, 특히 전술한 병원균에 쉽게 적용될 수 있음은 분명하다.
놀랍게도, 본원 발명에 따른 방법은 병원균이 효율적으로 퇴치될 수 있는 상황에서도 환자 항체 레퍼토리의 극히 일부만 일정한 병원균을 지향한다는 사실에 비추어, 일정한 병원균의 효율적이고 신속한 선별을 가능하게 한다. 본원 발명의 과정에서, 특히 스타필로코커스 아우레우스(S. aureus)의 실행동안 스타필로코커스 아우레우스(S. aureus)에 높은 역가를 갖는 환자의 항체 레퍼토리 중에서 단지 1-2%만 실제로 스타필로코커스 아우레우스(S. aureus)에 대한 항체인 것으로 확인되었다. 게다가, 이런 특이적 1% 부분의 70% 이상은 비-단백질 항원, 예를 들면, 테 이코산(teichoic acid)을 지향하기 때문에, 항체 중에서 단지 0.1% 이하만이 단백질성 항원을 지향한다.
재조합 발현 라이브러리, 특히 리보솜 전시 라이브러리와 박테리아 표면 전시 라이브러리를 이용하는 이점중의 하나는 확인된 과다면역 혈청-반응성 항원이 추가적인 재조합 DNA 기술 또는 클로닝 단계없이 과다면역 혈청-반응성 항원을 발현하는 선별되고 선택된 클론의 코딩 서열의 발현으로 즉시 생성될 수 있다는 점이다.
따라서, 본원 발명에 따른 방법으로 수득되는 과다면역 혈청-반응성 항원은 예로써, 발현 라이브러리 플랫폼으로부터 발현으로, 생산 직후(2차 선별 단계 과정동안) 제약학적으로 수용가능한 담체 및/또는 부형제를 첨가하여 제약학적 조성물로 마감될 수 있다.
적절하게는, 과다면역 혈청-반응성 항원을 함유하는 제약학적 조성물은 항원이 선별된 특정 병원균의 감염을 예방 또는 치료하는 백신이다.
이런 제약학적 조성물은 적절한 보조 물질, 예를 들면, 완충물질, 안정제 또는 다른 활성 성분, 특히 백신 생산에 공지된 성분을 함유할 수 있다.
본원 발명에 따른 과다면역 혈청-반응성 항원에 적합한 담체 및/또는 부형제는 일정한 과다면역 혈청-반응성 항원에 대한 면역 반응을 더욱 촉진하는 면역촉진 화합물이다. 적절하게는, 본원 발명에 따른 제약학적 조성물에서 면역조절 화합물은 다가양이온 물질, 특히 다가양이온성 펩티드, 면역촉진 데옥시뉴클레오티드, 알루멘, 프레운드 완전 어쥬번트, 프레운드 불완전 어쥬번트, 신경활성 화합물, 특히 인간 성장 호르몬, 또는 이들의 혼합물에서 선택된다.
본원 발명에 사용되는 다가양이온성 화합물은 WO 97/30721에 따른 특징적인 효과를 보이는 임의의 다가양이온성 화합물일 수 있다. 바람직한 다가양이온성 화합물은 염기성 폴리펩티드, 유기 다가양이온, 염기성 폴리아미노산 또는 이들의 혼합물에서 선택된다. 이들 폴리아미노산은 적어도 4개 아미노산 잔기의 사슬 길이를 갖는다(Goldman et al., (1983)에서 Tuftsin). 특히 폴리리신, 폴리아르기닌 및 8개 이상, 적절하게는, 20개 이상의 아미노산 잔기 범위에서 20% 이상, 적절하게는, 50% 이상의 염기성 아미노산을 보유하는 폴리펩티드 또는 이들의 혼합물과 같은 물질이 바람직하다. 다른 바람직한 다가양이온과 이들의 제약학적 조성물은 WO97/30721(예, 폴리에틸렌이민) 및 WO99/38528에 기술되어 있다. 적절하게는, 이들 조성물은 20 내지 500개 아미노산 잔기, 바람직하게는, 30 내지 200개 잔기를 보유한다.
이들 다가양이온성 화합물은 화학적으로 혹은 재조합으로 생산되거나, 또는 천연 공급원으로 유도될 수 있다.
양이온성(폴리) 펩티드는 또한 Ganz and Lehrer, 1999에서 검증된 특성을 갖는 항균 펩티드일 수도 있다. 이들 (폴리)펩티드는 원핵생물, 동물 또는 식물로부터 기원하거나, 또는 화학적으로 혹은 재조합으로 생산될 수 있다(Andreu and Rivas, 1998; Ganz and Lehrer, 1990; Simmaco et al., 1998). 펩티드는 디펜신(defensin) 군에 속할 수도 있다(Ganz, 1999; Ganz and Lehrer, 1999). 이런 펩티드의 서열은 예로써, 다음과 같은 인터넷 주소하의 항균 서열 데이터에서 찾을 수 있다: http://www.bbcm.univ.trieste.it/~tossi/pag1.html.
이런 숙주 방어 펩티드 또는 방어물질 역시 본원 발명에 따른 다가양이온 중합체의 적합한 형태이다. 일반적으로, 최종 산물로서 APC(수상돌기 세포 포함)에 의해 매개되는 적응성 면역계의 최종 산물 활성화(또는 하향-조절)를 가능하게 하는 화합물이 다가양이온성 중합체로 사용된다.
카텔리시딘 유도된 항균펩티드 또는 이들의 유도체(PCT/EP01/09529), 특히 포유동물 카텔리시딘, 적절하게는, 사람, 소 또는 생쥐로부터 유래된 항균 펩티드가 본원 발명에 따른 다가양이온 물질로 적합하다.
천연 공급원으로부터 유래된 다가양이온성 화합물에는 HIV-REV 또는 HIV-TAT [유도된 양이온성 펩티드, 안테나페디아(antennapedia) 펩티드, 키토산 또는 키틴의 다른 유도체] 또는 생화학적 혹은 재조합적 생산으로 이들 펩티드나 단백질로부터 유도된 다른 펩티드가 포함된다. 다른 바람직한 다가양이온성 화합물은 카텔린 또는 카텔린과 관련되거나 이로부터 유래된 물질이다. 가령, 생쥐 카텔린은 아미노산 서열 NH2-RLAGLLRKGGEKIGEKLKKIGOKIKNFFQKLVPQPE-COOH을 보유하는 펩티드이다. 관련되거나 유래된 카텔린 물질은 적어도 15-20개 아미노산 잔기를 보유하는 카텔린 서열의 전체 또는 일부를 포함한다. 유도에는 고유 아미노산의 20개 표준 아미노산을 제외한 다른 아미노산의 치환 또는 변경이 포함될 수 있다. 게다가, 추가적인 양이온성 잔기가 이런 카텔린 분자에 도입될 수 있다. 적절하게는, 이들 카텔린 분자는 항원과 결합된다. 놀랍게도, 이들 카텔린 분자는 추가적인 어쥬번트의 첨가 없이 항원에 대한 어쥬번트로서 효과적인 것으로 확인되었다. 따라서, 추가적인 면역활성 물질과 함께 또는 이런 면역활성 물질없이 백신 제형에 효과적인 어쥬번트로 이런 카텔린을 사용하는 것이 가능하다.
본원 발명에 사용되는 다른 적절한 다가양이온 물질은 3 내지 7개의 소수성 아미노산의 링커에 의해 분리되는 적어도 2개의 KLK-모티프를 보유하는 합성 펩티드이다(PCT/EP01/12041).
면역촉진 데옥시뉴클레오티드 자연이나 인공 CpG를 포함하는 DNA, 비-척추동물로부터 유래된 짧은 DNA 스트레치, 특정 염기 환경에 비-메틸화된 시토신-구아닌 이중-뉴클레오티드(CpG)를 포함하는 짧은 올리고뉴클레오티드(ODN)(Krieg et al., 1995) 또는 이노신을 포함하는 ODN(I-ODN)(WO 01/93905)이다.
예로써, 다가양이온성 물질과 결합된 신경활성 화합물은 WO 01/24822에서 기술한다.
적절한 구체예에 따라, 2차 선별을 위한 개별 항체 조제물은 일정한 병원균으로 급성 감염된 환자, 특히 일정한 병원균에 대한 특정 수준이상의 항체 역가, 예를 들면, 검사된 인체(환자 또는 보균자) 혈청의 80 백분위수 이상, 더욱 바람직하게는, 90 백분위수 이상, 가장 바람직하게는, 95 백분위수 이상의 항체 역가를 보이는 환자로부터 유래된다. 2차 선별에 이런 높은 역가 개별 항체 조제물을 이용하는 것은 일정한 병원균에 대한 과다면역 혈청-반응성 항원의 매우 선택적인 동정을 가능하게 한다.
개별 항체 조제물(또는 선택된 혈청)을 이용한 2차 선별로 1차 선별의 모든 유망한 후보로부터 과다면역 혈청-반응성 항원을 선별적으로 확인하는 것이 중요하다. 따라서, 적어도 10개의 개별 항체 조제물(즉, 선택된 병원균에 감염된 적어도 10명의 개체로부터 유래된 항체 조제물(예, 혈청))이 2차 선별에서 이들 항원을 확인하는데 사용되어야 한다. 물론, 10개 이하의 개별 조제물을 사용하는 것도 가능하긴 하지만, 이 단계의 선별감도가 적은 수의 개별 항체 조제물에서 최적화되지 않을 수 있다. 다른 한편, 과다면역 혈청-반응성 항원(또는 이의 항원성 단편)이 적어도 10개, 바람직하게는, 적어도 30개, 더욱 바람직하게는, 적어도 50개의 개별 항체 조제물에서 인식된다면, 과다면역 혈청-반응성 항원의 동정 역시 적절한 동정이 가능할 만큼 충분히 선별적이다. 과다면역 혈청-반응성은 가능한 많은 개별 조제물(예, 100개 또는 1000개 이상)로 검사할 수도 있다.
따라서, 본원 발명의 방법에 따른 과다면역 혈청-반응성 항체 조제물의 적절한 부분은 바람직하게는, 적어도 10개, 더욱 바람직하게는, 적어도 30개, 가장 바람직하게는, 적어도 50개의 개별 항체 조제물이다. 대안으로, 과다면역 혈청-반응성 항원은 2차 선별에 사용되는 모든 개별 항체 조제물의 적어도 20%, 바람직하게는, 적어도 30%, 더욱 바람직하게는, 적어도 40%로 확인될 수도 있다.
본원 발명의 적절한 구체예에 따라, 2차 선별을 위한 개별 항체 조제물이 만들어지는(또는 항체 조제물로 사용되는) 혈청은 특정 병원균(예, 용해질, 세포벽, 재조합 단백질과 같은 이런 병원균의 조제물)에 대한 역가로 선택된다. 적절하게는, 전체 미생물(전체 용해질 또는 전체 세포)이 ELISA에서 항원으로 이용되는 경우에 일부는 4000 U이상, 특히 6000 U이상의 IgA 역가 및/또는 10,000 U이상, 특히 12,000 U이상의 IgG 역가(U= 단위, 일정한 희석도에서 OD405nm 판독으로 계산)로 선택된다. 800-1000 U이상의 Ig 역가를 갖는 개별 단백질은 전체 역가만으로 본원 발명에 다른 과다면역 혈청-반응성 항원을 선별하는데 특히 적합하다. 개별 단백질에 대한 설명은 도 9로부터 도출할 수 있다.
본원 발명의 적절한 구체예에서, 일정한 병원균은 스타필로코커스(Staphylococcus) 병원균, 특히 스타필로코커스 아우레우스(Staphylococcus aureus)와 스타필로코커스 에피데르미디스(Staphylococcus epidermidis)이다. 스타필로코커스(Staphylococcus)는 가벼운 감염에서 치명적인 질환까지 유발할 수 있는 기회적 병원균이다. 많은 스타필로코커스(Staphylococcus)중에서, 적어도 3가지가 인간 질환과 연관한다: 스타필로코커스 아우레우스(S. aureus), 스타필로코커스 에피데르미디스(S. epidermidis), 드물지만 스타필로코커스 사프로피티쿠스(S. saprophyticus)(Crossley and Archer, 1997). 스타필로코커스 아우레우스(S. aureus)는 본원 발명에서 본원 발명이 작동하는 방식을 설명하는 전형으로 사용되었다. 이는 인체에 대한 심각한 병원성 효과의 측면에서도 중요한 미생물이다. 스타필로코커스(Staphylococcus) 감염은 전세계 병원에 점점 더 많은 위협을 강요하고 있다. 스타필로코커스(Staphylococcus)의 출현과 질병 유발 능력은 다중-약물 저항성을 유도하고 지속시키는 항생제의 광범위한 사용과 연관한다. 이런 이유로, 스타필로코커스(Staphylococcus) 감염에 대한 의학적 치료는 더 이상 항생제에 의존할 수 없다. 따라서, 이들 질환의 치료에서 감염을 예방하기 위한 전술적 변화가 절실히 요구되고 있다. 예방접종에 의한 옵소닉(opsonic)과 중화 유형의 높은 친화성 항체를 유도하는 것은 선천성 면역계가 박테리아와 독소를 제거하는데 효과적이다. 이로 인해 본원 발명에 따른 방법은 스타필로코커스(Staphylococcus) 항원성 단백질 동정에 최적의 도구이다.
모든 사람에서 스타필로코커스 에피데르미디스(S. epidermidis)가 상재한다. 스타필로코커스 에피데르미디스(S. epidermidis)의 정상적인 번식지는 피부와 점막이다. 가장 병원성이 강한 종인 스타필로코커스 아우레우스(S. aureus)의 주요 번식지는 외비공(anteriornare)과 회음이다. 일부 개체는 동일한 균주를 갖는 영구적인 스타필로코커스 아우레우스(S. aureus) 보균자가 된다. 보균자 단계는 수술동안 보균자가 비-보균자보다 더욱 쉽게 감염되기 때문에 임상적으로 중요하다. 일반적으로, 코의 확립된 균총은 새로운 균주의 획득을 예방한다. 하지만, 항생제 치료로 민감한 보균자 균주가 제거되면 다른 균주의 상재화(colonization)가 진행될 수 있다. 이런 상황이 병원에서 발생하고 있기 때문에, 환자에 저항성의 병원성 스타필로코커스(Staphylococcus)의 상재화가 진행될 수 있다. 이들 박테리아는 항균제의 광범위하고 부적절한 사용으로 보조되는 선천적 적응성을 갖는다. 따라서, 병원은 약물 저항성이 발생하는데 풍부한 환경을 제공한다(병든 환자간 접촉, 항균제의 광범위한 사용, 병원성 감염). 스타필로코커스 아우레우스(S. aureus)와 스타필로코커스 에피데르미디스(S. epidermidis)는 많은 통상적으로 사용되는 항생제, 특히 메티실린(MRSA)과 반코마이신(VISA)에 저항성을 보이고 있다. 약물 저항성은 공중 보건에 점점 더 위협이 되고 있으며, 조만간 스타필로코커스(Staphylococcus)에 의 해 유발된 감염이 항생제에 의해 통제되지 않을 수 있다. 공중 보건에 대한 부작용이외에, 저항성 감염을 치료하는데 독성이 더욱 강하고 가격이 더욱 비싼 약물이 사용되어야 하고 감염된 환자가 더욱 오랜 기간동안 병원에 입원해야 한다는 점에서, 항균제 저항성은 더 높아진 건강 관리 비용의 원인이 되고 있다. 게다가, 효과적인 항생제의 도움에도 불구하고 가장 심각한 스타필로코커스(Staphylococcus) 감염은 30-50% 치사율을 갖는다.
스타필로코커스(Staphylococcus)는 자연 장벽(피부, 점막)이 파괴될 때, 미생물과 면역계간 자연적 균형이 교란되는 즉시 강력한 병원균으로 변모한다. 코아굴라제(coagulase)-양성 스타필로코커스(Staphylococcus)는 외과 의사들이 오랜 기간동안 우려해온 가장 강력한 병원성 스타필로코커스(Staphylococcus) 종이다. 이는 빈번하게 수술 상처 감염을 유발하고 농양 형성을 유도한다. 이런 국소적 감염은 전신적으로 확대되어 균혈증과 패혈증을 유발할 수 있다. 특히 바이러스 감염이후와 노년기에 이는 중증 폐렴을 유발할 수 있다. 스타필로코커스 아우레우스(S. aureus)는 또한, 의료 장치, 예를 들면, 혈관내와 경피 카테터(심장 내막염, 패혈증, 복막염), 보철 장치(패혈성 관절염, 골수염)와 관련된 감염의 주요 원인이다. 스타필로코커스 에피데르미디스(S. epidermidis)는 주로 외래 물체의 존재 및 장치의 사용과 관련된 질환, 예를 들면, 카테터 관련된 감염, 척수액 문합 감염, 투석 환자에서 복막염(주로 CAPD), 인공 판막을 가진 개체에서 심장 내막염을 유발한다. 이는 혈관내 장치의 이용과 관련하여 코아굴라제-음성 스타필로코커스(Staphylococcus) 감염이 빈번하게 발생하는 종양 환자 및 조산아와 같은 면역약 화된 개체에서 예증된다. 발병률 증가는 이들 장치의 증가된 이용 및 면역약화된 환자 수의 증가와 연관한다.
다른 덜 알려진 코아굴라제-음성 스타필로코커스(Staphylococcus)인 스타필로코커스 사프로피티쿠스(S. saprophyticus)는 건강한 사람에서 급성 요로 감염을 유발한다. 일부 사례를 제외하고 이들은 16-25세의 여성이다.
스타필로코커스(Staphylococcus)의 병인은 다인적이다. 감염을 개시하기 위하여, 병원균은 부착할 수 있는 숙주의 세포와 조직에 접근해야 한다. 스타필로코커스 아우레우스(S. aureus)는 라미닌, 피브로넥틴, 엘라스틴, 비트로넥틴, 피브리노겐 및 세포외 매트릭스의 일부를 형성하는 많은 다른 분자(세포외 매트릭스 결합 단백질, ECMBP)와 같은 숙주 단백질에 부착을 촉진하는 표면 단백질을 발현한다. 스타필로코커스 에피데르미디스(S. epidermidis)는 외래 물질에 부착을 촉진하는 세포 표면 분자를 구비하고, 이런 기전을 통하여 숙주에 감염을 확립한다. 스타필로코커스(Staphylococcus)가 사용하는 다른 강력한 무기는 분비된 단백질, 예를 들면, 내독소, 외독소, 조직 손상 효소이다. 독소는 숙주 방어에 중요한 면역세포를 죽이거나 오도한다. 여러 상이한 유형의 독소가 감염동안 나타나는 대부분 증상의 원인이 된다.
스타필로코커스 아우레우스(S. aureus)에 대한 숙주 방어는 선천성 면역 기전에 주로 의존한다. 피부와 점막은 스타필로코커스(Staphylococcus) 침입에 대한 강력한 장벽이다. 하지만, 피부 또는 점막이 일단 파괴되면(상처, 경피 카테터 등), 제 1 선의 비적응성 세포 방어는 보체와 식세포, 특히 다형핵 백혈구(PMN)를 통 하여 공동 작용을 시작한다. 이들 세포는 침입 박테리아를 제거하는데 시금석으로 간주할 수 있다. 스타필로코커스(Staphylococcus)는 주로 세포외 병원균이기 때문에, 주요 항-스타필로코커스(Staphylococcus) 적응성 반응은 면역계의 체액 계통으로부터 유래되고 3가지 주요 기전에 의해 매개된다: 옵소닌화(opsonization)의 촉진, 독소 중화, 부착 저해. 옵소닌화가 특히 중요한 것으로 생각되는데, 그 이유는 옵소닌화가 효과적인 식세포작용에 필요하기 때문이다. 효과적인 옵소닌화를 위하여, 미생물 표면은 IgG 분자의 Fc 단편 또는 활성화된 C3b에 대한 수용체를 통하여 PMN에 의해 인식되는 항체와 보체 인자로 피복되어야 한다. 옵소닌화이후, 스타필로코커스(Staphylococcus)는 식세포작용으로 사멸된다. 더욱이, 스타필로코커스 아우레우스(S. aureus)는 내피 세포에 의해 부착하고 식세포작용-유사 과정에 의해 내재화될 수 있다. 박테리아의 세포 표면에서 특정 항원에 결합하는 항체는 PMN에 부착을 위한 리간드로 작용하고 식세포작용을 촉진한다. 부착성분(adhesin)에 결합된 거의 동일한 항체 및 다른 세포 표면 단백질은 부착을 중화시키고 상재화를 예방할 것으로 기대된다.
세포 매개된 면역이 스타필로코커스(Staphylococcus)에 대한 방어에 현저하게 기여한다는 임상적 증거는 없으며, 이 문제는 아직 해결되지 않고 있다. 하지만, 스타필로코커스 아우레우스(S. aureus)가 초항원이라고 하는 폴리펩티드를 분리함으로써 감염된 숙주의 방어 미세환경을 조작하는 광범위한 분자 대항 수단을 이용하는 것으로 알려져 있는데, 상기 초항원은 병원균-특이적 면역 제거를 개시하는데 필수적인 T-세포와 항원-제시 세포간 다중수용체 신호전달을 표적으로 한다. 초항원은 독성 쇼크 증후군과 식중독에서 핵심적인 역할을 하지만, 통상적인 감염에서 이들의 역할은 아직 확실하지 않다. 게다가, T-세포의 참여 없이는 장기간 지속하는 항체(기억) 반응을 기대할 수 없다. 항-스타필로코커스(Staphylococcus) 항체의 대부분은 기억 능력없이 T-세포 독립된 항원(협막 폴리사카라이드, 리포테이코산, 펩티도글리칸)을 지향하는 것으로 알려져 있다. T-세포 의존한 단백질성 항원은 장기간 보호 항체 반응을 유도할 수 있다. 이들 스타필로코커스(Staphylococcus) 단백질과 펩티드는 아직 확인되지 않았다.
전술한 이유로, 스타필로코커스(Staphylococcus) 감염과의 전쟁에서 전술적 변화가 시급히 필요하다. 감염을 억제하는 한가지 방법은 활성 면역화로 이들을 예방하는 것이다. 스타필로코커스 아우레우스(S. aureus)에 대한 백신 개발은 여러 연구 그룹과 전세계 국립 기관에 의해 시작되었지만, 지금까지 승인을 받은 효과적인 백신은 없다. 항체 결핍 상태가 스타필로코커스(Staphylococcus) 지속의 원인인 것으로 밝혀졌는데, 이는 항-스타필로코커스(Staphylococcus) 항체가 숙주 방어에 중요하다는 것을 암시한다. 표면 구성요소를 지향하는 항체(수동 면역으로 추가되거나 또는 활성 예방접종으로 유도된)는 박테리아 부착을 예방하고 독소를 중화시키며 식세포를 촉진할 수 있다. 피브로넥틴 결합 단백질에 기초한 백신은 소에서 유선염(mastitis)에 대한 보호 면역을 유도하는데, 이런 사실은 이런 접근방식이 사람에서도 유효하다는 것을 암시한다. 이를 종합하면, 효과적인 백신은 모든 균주에 의해 발현되고 스타필로코커스 아우레우스(S. aureus)의 세포 표면 구성요소에 대한 풍부한 높은 친화성 항체를 유도할 수 있는 단백질이나 폴리펩티드로 구성되 어야 한다는 것을 알 수 있다. 항체는 옵소닌화를 위해서는 IgG1 및/또는 IgG3이어야 하고, 부착과 독소 작용의 중화를 위해서는 IgG 아형과 IgA이어야 한다. 화학적으로 규정된 백신은 전체 세포 백신(약독화 또는 사멸된)과 비교하여 명확하게 우월한데, 그 이유는 TH 세포를 마비시키거나(초항원) 옵소닌화를 저해하는(단백질 A) 스타필로코커스 아우레우스(S. aureus)의 구성요소가 제거될 수 있고 보호 항체를 유도하는 개별 단백질이 선택될 수 있기 때문이다. 적절한 항원의 동정은 효과적인 수동 면역(인화 단클론 항체 요법)을 결과하는데, 이는 위험한 부작용을 유발하는 인간 면역글로불린 투여를 대체할 수 있다. 신생아 스타필로코커스(Staphylococcus) 감염, 중증 균혈증, 다른 생명-위협 급성 질환이 수동 면역의 일차 표적이다. 효과적인 백신은 일반적인 선택적 수술을 받는 환자 및 특히 혈관내막 장치를 집어넣은 환자에게 상당한 가능성을 제공한다. 게다가, 면역 반응을 감소시키거나 지속적인 보행성 복막 투석을 받은 만성 질환 환자 역시 이런 백신으로부터 혜택을 얻을 수 있다.
스타필로코커스 아우레우스(S. aureus)와 관련된 전형에서, 3가지 별개의 접근방식이 동시에 이용되었다. 이들 3가지 방법은 본원 발명에 따른 방법으로 스타필로코커스(Staphylococcus) 단백질이나 펩티드와 인간 혈청에 존재하는 항체의 상호작용에 기초한다. 이런 상호작용은 짧은 펩티드(선형 에피토프) 또는 폴리펩티드 도메인(구조 에피토프)이 되는 단백질내 에피토프의 인식에 의존한다. 항원성 단백질은 사전-선택된 혈청의 풀(pool)을 이용한 여러 가지 방법 및 개별 선택된 항원(2차 선별에서)에 의해 확인된다.
고성능 선별이후, 선택된 항원성 단백질은 재조합 단백질 또는 시험관내 번역된 산물(원핵 발현 시스템에서 발견될 수 없는 경우에)로 발현되는데, 대량의 인간 혈청 수집물(>100 감염되지 않은 혈청, >50 환자 혈청)로 면역성의 평가를 위한 일련의 ELISA와 웨스턴 블랏팅 분석으로 검사한다. 바람직한 항원은 세포 표면에 위치하거나 분리된다, 다시 말하면, 세포외적으로 접근가능하다. 세포벽 단백질(예, 세포외 매트릭스 결합 단백질)에 대한 항체는 이중 목적: 부착 저해와 식세포작용 촉진을 달성할 것으로 기대된다. 분비된 단백질에 대한 항체는 독소 중화에 유효하다. 박테리아는 분비된 단백질을 통하여 서로 신호를 전달하는 것으로 알려져 있다. 이들 단백질에 대한 중화 항체는 스타필로코커스(Staphylococcus) 종간이나 이들 종내에서 성장 촉진 세포내 연결망(cross-talk)을 교란시킨다. 생물정보학(신호, 서열, 세포벽 국소화 신호, 막통 도메인)은 세포 표면 국지화 또는 분비를 평가하는데 매우 유용한 것으로 입증되었다. 이런 실험 접근방식은 인간 혈청으로부터 상응하는 에피토프와 단백질로 항체를 분리하고 다음의 분석에 이들을 시약으로 사용하는 단계로 구성된다: 상이한 조건하에 배양된 스타필로코커스(Staphylococcus)의 세포 표면 염색(FACS, 현미경), 중화 능력의 측정(독소, 부착), 옵소닌화와 식세포작용의 촉진(시험관내 식세포작용 분석).
항체에 의한 선형 에피토프의 인식은 4-5개 aa의 짧은 서열에 기초할 수 있다. 하지만, 이들 짧은 펩티드가 생체내에서 항체를 반드시 유도할 수 있는 것은 아니다. 이런 이유로, 규정된 에피토프, 폴리펩티드, 단백질은 선별된 단백질에 대한 항체를 생체내에서 유도하는 능력을 동물(주로 쥐)에서 추가로 검사할 수 있다. 항체를 유도하는 능력이 입증된 항원은 감염을 예방하는 능력을 동물 모델에서 검사한다.
인간 면역계에 의해 생산되고 인간 혈청에 존재하는 스타필로코커스(Staphylococcus)에 대한 항체는 항원성 단백질의 생체내 발현 및 이들의 면역원성을 지시한다.
따라서, 스타필로코커스 아우레우스(S. aureus)와 스타필로코커스 에피데르미디스(S. epidermidis)로부터 유래된 신규한 과다면역 혈청-반응성 항원은 본원 발명에 따른 방법으로 제조되었다. 본원 발명의 다른 측면에서, 본원 발명은 다음의 표 2a, 2b, 2c, 2d, 3, 4, 5에 기재된 서열, 특히 Seq. ID No. 56, 57, 59, 60, 67, 70, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 85, 87, 88, 89, 90, 92, 95, 96, 97, 99, 100, 101, 102, 103, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 126, 128, 132, 134, 138, 140, 142, 151, 152, 154, 155, 이들의 과다면역 단편에서 선택되는 과다면역 혈청-반응성 항원에 관한다. 또한, 본원 발명은 본원 발명에 따른 방법으로 수득가능하고, 다음의 표 2a, 2b, 2c, 2d, 3, 4, 5에 기재된 서열, 특히 Seq. ID No. 56, 57, 59, 60, 67, 70, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 85, 87, 88, 89, 90, 92, 95, 96, 97, 99, 100, 101, 102, 103, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 126, 128, 132, 134, 138, 140, 142, 151, 152, 154, 155, 이들의 과다면역 단편에서 선택되는 과다면역 혈청-반응성 항원에 관한다.
스타필로코커스 아우레우스(S. aureus)와 스타필로코커스 에피데르미디스(S. epidermidis)로부터 유래된 항원은 본원 발명에 따른 방법으로 추출되었는데, 이들 항원은 제약학적 조성물, 특히 스타필로코커스 아우레우스(S. aureus)와 스타필로코커스 에피데르미디스(S. epidermidis) 감염에 대한 백신의 제조에 사용될 수 있다. 제약학적 조성물의 제조, 특히 스타필로코커스 아우레우스(S. aureus)와 스타필로코커스 에피데르미디스(S. epidermidis) 감염에 대한 백신의 제조에 사용되는 스타필로코커스 아우레우스(S. aureus)와 스타필로코커스 에피데르미디스(S. epidermidis)의 이런 과다면역 혈청-반응성 항원의 예는 표 2a, 2b, 2c, 2d, 3, 4, 5에 기재된 서열, 특히 Seq. ID No. 56, 57, 58, 59, 60, 62, 66, 67, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 87, 88, 89, 90, 92, 94, 95, 96, 97, 99, 100, 101, 102, 103, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 126, 128, 130, 132, 134, 138, 140, 142, 151, 152, 154, 155, 158, 이들의 과다면역 단편에서 선택된다.
과다면역 단편은 자체로써 항원성이거나 합텐으로 제공되면 항원성을 나타낼 수 있는 동정된 항원의 단편으로 정의된다. 따라서, 한 개 또는 여러 개의 아미노산 치환을 갖는 항원이나 항원성 단편 역시 이런 단편의 항원성 능력이 치환으로 심각하게 저하되지 않는 조건하에, 다시 말하면, 이런 항원으로 예방접종된 개체에서 적절한 면역 반응을 유도하는데 적합하고 개별 혈청으로부터 유래된 개별 항체 조제물에 의해 확인되는 조건하에 본원 발명에 유효하다.
과다면역 혈청-반응성 항원의 이런 과다면역 단편의 바람직한 예는 표 2a, 2b, 2c, 2d의 “예상 면역원성 aa”, “동정된 면역원성 영역의 위치”, “관련된 영역과의 혈청 반응성” 칼럼의 아미노산 서열 및 표 4와 5의 “추정 항원성 표면 영역”의 아미노산 서열, 특히, 다음의 아미노산 서열 및 상기 서열의 적어도 6개, 바람직하게는, 적어도 8개, 더욱 바람직하게는, 적어도 10개 aa 단편을 포함하는 펩티드에서 선택된다:
서열 번호 55의 아미노산(aa) 12-29, 34-40, 63-71, 101-110, 114-122, 130-138, 140-195, 197-209, 215-229, 239-253, 255-274, 39-94;
서열 번호 56의 aa 5-39, 111-117, 125-132, 134-141, 167-191, 196-202, 214-232, 236-241, 244-249, 292-297, 319-328, 336-341, 365-380, 385-391, 407-416, 420-429, 435-441, 452-461, 477-488, 491-498, 518-532, 545-556, 569-576, 581-587, 595-602, 604-609, 617-640, 643-651, 702-715, 723-731, 786-793, 805-811, 826-839, 874-889, 37-49, 63-77, 274-334;
서열 번호 57의 aa 28-55, 82-100, 105-111, 125-131, 137-143, 1-49;
서열 번호 58의 aa 33-43, 45-51, 57-63, 65-72, 80-96, 99-110, 123-129, 161-171, 173-179, 185-191, 193-200, 208-224, 227-246, 252-258, 294-308, 321-329, 344-352, 691-707, 358-411, 588-606;
서열 번호 59의 aa 16-38, 71-77, 87-94, 105-112, 124-144, 158-164, 169-177, 180-186, 194-204, 221-228, 236-245, 250-267, 336-343, 363-378, 385-394, 406-412, 423-440, 443-449, 401-494;
서열 번호 60의 aa 18-23, 42-55, 69-77, 85-98, 129-136, 182-188, 214-220, 229-235, 242-248, 251-258, 281-292, 309-316, 333-343, 348-354, 361-367, 393-407, 441-447, 481-488, 493-505, 510-515, 517-527, 530-535, 540-549, 564-583, 593-599, 608-621, 636-645, 656-670, 674-687, 697-708, 726-734, 755-760, 765-772, 785-792, 798-815, 819-824, 826-838, 846-852, 889-904, 907-913, 932-939, 956-964, 982-1000, 1008-1015, 1017-1024, 1028-1034, 1059-1065, 1078-1084, 1122-1129, 1134-1143, 1180-1186, 1188-1194, 1205-1215, 1224-1230, 1276-1283, 1333-1339, 1377-1382, 1415-1421, 1448-1459, 1467-1472, 1537-1545, 1556-1566, 1647-1654, 1666-1675, 1683-1689, 1722-1737, 1740-1754, 1756-1762, 1764-1773, 1775-1783, 1800-1809, 1811-1819, 1839-1851, 1859-1866, 1876-1882, 1930-1939, 1947-1954, 1978-1985, 1999-2007, 2015-2029, 2080-2086, 2094-2100, 2112-2118, 2196-2205, 2232-2243, 198-258, 646-727, 2104-2206;
서열 번호 62의 aa 10-29, 46-56, 63-74, 83-105, 107-114, 138-145, 170-184, 186-193, 216-221, 242-248, 277-289, 303-311, 346-360, 379-389, 422-428, 446-453, 459-469, 479-489, 496-501, 83-156;
서열 번호 66의 aa 14-22, 32-40, 52-58, 61-77, 81-93, 111-117, 124-138, 151-190, 193-214, 224-244, 253-277, 287-295, 307-324, 326-332, 348-355, 357-362, 384-394, 397-434, 437-460, 489-496, 503-510, 516-522, 528-539, 541-547, 552-558, 563-573, 589-595, 602-624, 626-632, 651-667, 673-689, 694-706, 712-739, 756-790, 403-462;
서열 번호 67의 aa 49-56, 62-68, 83-89, 92-98, 109-115, 124-131, 142-159, 161-167, 169-175, 177-188, 196-224, 230-243, 246-252, 34-46;
서열 번호 70의 aa 11-20, 26-47, 69-75, 84-92, 102-109, 119-136, 139-147, 160-170, 178-185, 190-196, 208-215, 225-233, 245-250, 265-272, 277-284, 300-306, 346-357, 373-379, 384-390, 429-435, 471-481, 502-507, 536-561, 663-688, 791-816, 905-910, 919-933, 977-985, 1001-1010, 1052-1057, 1070-1077, 1082-1087, 1094-1112, 493-587, 633-715, 704-760;
서열 번호 71의 aa.6-20, 53-63, 83-90, 135-146, 195-208, 244-259, 263-314, 319-327, 337-349, 353-362, 365-374, 380-390, 397-405, 407-415, 208-287, 286-314;
서열 번호 72의 aa 10-26, 31-43, 46-58, 61-66, 69-79, 85-92, 100-115, 120-126, 128-135, 149-155, 167-173, 178-187, 189-196, 202-222, 225-231, 233-240, 245-251, 257-263, 271-292, 314-322, 325-334, 339-345, 59-74;
서열 번호 73의 aa 4-9, 15-26, 65-76, 108-115, 119-128, 144-153, 38-52, 66-114,
서열 번호 74의 aa 5-22, 42-50, 74-81, 139-145, 167-178, 220-230, 246-253, 255-264, 137-237, 250-267;
서열 번호 75의 aa 10-26, 31-44, 60-66, 99-104, 146-153, 163-169, 197-205, 216-223, 226-238, 241-258, 271-280, 295-315, 346-351, 371-385, 396-407, 440-446, 452-457, 460-466, 492-510, 537-543, 546-551, 565-582, 590-595, 635-650, 672-678, 686-701, 705-712, 714-721, 725-731, 762-768, 800-805, 672-727;
서열 번호 76의 aa 5-32, 35-48, 55-76;
서열 번호 77의 aa 7-35, 54-59, 247-261, 263-272, 302-320, 330-339, 368-374, 382-411, 126-143, 168-186;
서열 번호 78의 aa 5-24, 88-94, 102-113, 132-143, 163-173, 216-224, 254-269, 273-278, 305-313, 321-327, 334-341, 31-61, 58-74;
서열 번호 79의 aa 16-24, 32-39, 43-49, 64-71, 93-99, 126-141, 144-156, 210-218, 226-233, 265-273, 276-284, 158-220;
서열 번호 80의 aa 49-72, 76-83, 95-105, 135-146, 148-164, 183-205, 57-128;
서열 번호 81의 aa 6-15, 22-32, 58-73, 82-88, 97-109, 120-131, 134-140, 151-163, 179-185, 219-230, 242-255, 271-277, 288-293, 305-319, 345-356, 368-381, 397-406, 408-420, 427-437, 448-454, 473-482, 498-505, 529-535, 550-563, 573-580, 582-590, 600-605, 618-627, 677-685, 718-725, 729-735, 744-759, 773-784, 789-794, 820-837, 902-908, 916-921, 929-935, 949-955, 1001-1008, 1026-1032, 1074-1083, 1088-1094, 1108-1117, 1137-1142, 1159-1177, 1183-1194, 1214-1220, 1236-1252, 1261-1269, 1289-1294, 1311-1329, 1336-1341, 1406-1413, 1419-1432, 1437-1457, 1464-1503, 1519-1525, 1531-1537, 1539-1557, 1560-1567, 1611-1618, 1620-1629, 1697-1704, 1712-1719, 1726-1736, 1781-1786, 1797-1817, 1848-1854, 1879-1890, 1919-1925, 1946-1953, 1974-1979, 5-134;
서열 번호 82의 aa 6-33, 40-46, 51-59, 61-77, 84-104, 112-118, 124-187, 194-248, 252-296, 308-325, 327-361, 367-393, 396-437, 452-479, 484-520, 535- 545, 558-574, 582-614, 627-633, 656-663, 671-678, 698-704, 713-722, 725-742, 744-755, 770-784, 786-800, 816-822, 827-837, 483-511,
서열 번호 83의 aa 4-19, 57-70, 79-88, 126-132, 144-159, 161-167, 180-198, 200-212, 233-240, 248-255, 276-286, 298-304, 309-323, 332-346, 357-366, 374-391, 394-406, 450-456, 466-473, 479-487, 498-505, 507-519, 521-530, 532-540, 555-565, 571-581, 600-611, 619-625, 634-642, 650-656, 658-665, 676-682, 690-699, 724-733, 740-771, 774-784, 791-797, 808-815, 821-828, 832-838, 876-881, 893-906, 922-929, 938-943, 948-953, 969-976, 1002-1008, 1015-1035, 1056-1069, 1105-1116, 1124-1135, 1144-1151, 1173-1181, 1186-1191, 1206-1215, 1225-1230, 1235-1242, 6-66, 65-124, 590-604;
서열 번호 84의 aa 5-32, 66-72, 87-98, 104-112, 116-124, 128-137, 162-168, 174-183, 248-254, 261-266, 289-303, 312-331, 174-249;
서열 번호 85의 aa 4-21, 28-40, 45-52, 59-71, 92-107, 123-137, 159-174, 190-202, 220-229, 232-241, 282-296, 302-308, 312-331, 21-118,
서열 번호 87의 aa 9-28, 43-48, 56-75, 109-126, 128-141, 143-162, 164-195, 197-216, 234-242, 244-251, 168-181;
서열 번호 88의 aa 4-10, 20-42, 50-86, 88-98, 102-171, 176-182, 189-221, 223-244, 246-268, 276-284, 296-329, 112-188;
서열 번호 89의 aa 4-9, 13-24, 26-34, 37-43, 45-51, 59-73, 90-96, 99-113, 160-173, 178-184, 218-228, 233-238, 255-262, 45-105, 103-166, 66-153;
서열 번호 90의 aa 13-27, 42-63, 107-191, 198-215, 218-225, 233-250, 474-367;
서열 번호 92의 aa 26-53, 95-123, 164-176, 189-199, 8-48;
*서열 번호 94의 aa 7-13, 15-23, 26-33, 68-81, 84-90, 106-117, 129-137, 140-159, 165-172, 177-230, 234-240, 258-278, 295-319, 22-56, 23-99, 97-115, 233-250, 245-265;
서열 번호 95의 aa 13-36, 40-49, 111-118, 134-140, 159-164, 173-183, 208-220, 232-241, 245-254, 262-271, 280-286, 295-301, 303-310, 319-324, 332-339, 1-85, 54-121, 103-185;
서열 번호 96의 aa 39-44, 46-80, 92-98, 105-113, 118-123, 133-165, 176-208, 226-238, 240-255, 279-285, 298-330, 338-345, 350-357, 365-372, 397-402, 409-415, 465-473, 488-515, 517-535, 542-550, 554-590, 593-601, 603-620, 627-653, 660-665, 674-687, 698-718, 726-739, 386-402;
서열 번호 97의 aa 5-32, 34-49, 1-43;
서열 번호 99의 aa 10-27, 37-56, 64-99, 106-119, 121-136, 139-145, 148-178, 190-216, 225-249, 251-276, 292-297, 312-321, 332-399, 403-458, 183-200;
서열 번호 100의 aa 5-12, 15-20, 43-49, 94-106, 110-116, 119-128, 153-163, 175-180, 185-191, 198-209, 244-252, 254-264, 266-273, 280-288, 290-297, 63-126;
서열 번호 101의 aa 5-44, 47-55, 62-68, 70-78, 93-100, 128-151, 166-171, 176-308, 1-59;
서열 번호 102의 aa 18-28, 36-49, 56-62, 67-84, 86-95, 102-153, 180-195, 198-218, 254-280, 284-296, 301-325, 327-348, 353-390, 397-402, 407-414, 431-455, 328-394;
서열 번호 103의 aa 7-37, 56-71, 74-150, 155-162, 183-203, 211-222, 224-234, 242-272, 77-128;
서열 번호 104의 aa 34-58, 63-69, 74-86, 92-101, 130-138, 142-150, 158-191, 199-207, 210-221, 234-249, 252-271, 5-48;
서열 번호 106의 aa 12-36, 43-50, 58-65, 73-78, 80-87, 108-139, 147-153, 159-172, 190-203, 211-216, 224-232, 234-246, 256-261, 273-279, 286-293, 299-306, 340-346, 354-366, 167-181;
서열 번호 112의 aa 61-75, 82-87, 97-104, 113-123, 128-133, 203-216, 224-229, 236-246, 251-258, 271-286, 288-294, 301-310, 316-329, 337-346, 348-371, 394-406, 418-435, 440-452;
서열 번호 114의 aa 30-37, 44-55, 83-91, 101-118, 121-128, 136-149, 175-183, 185-193, 206-212, 222-229, 235-242;
서열 번호 116의 aa 28-38, 76-91, 102-109, 118-141, 146-153, 155-161, 165-179, 186-202, 215-221, 234-249, 262-269, 276-282, 289-302, 306-314, 321-326, 338-345, 360-369, 385-391;
서열 번호 142의 aa 9-33, 56-62,75-84, 99-105, 122-127, 163-180, 186-192, 206-228, 233-240, 254-262, 275-283, 289-296, 322-330, 348-355, 416-424, 426-438, 441-452, 484-491, 522-528, 541-549, 563-569, 578-584, 624-641, 527-544;
서열 번호 151의 aa 37-42, 57-62, 121-135, 139-145, 183-190, 204-212, 220-227, 242-248, 278-288, 295-30, 304-309, 335-341, 396-404, 412-433, 443-449, 497-503, 505-513, 539-545, 552-558, 601-617, 629-649, 702-711, 736-745, 793-804, 814-829, 843-858, 864-885, 889-895, 905-913, 919-929, 937-943, 957-965, 970-986, 990-1030, 1038-1049, 1063-1072, 1080-1091, 1093-1116, 1126-1136, 1145-1157, 1163-1171, 1177-1183, 1189-1196, 1211-1218, 1225-1235, 1242-1256, 1261-1269, 624-684;
서열 번호 152의 aa 8-23, 31-38, 42-49, 61-77, 83-90, 99-108, 110-119, 140-147, 149-155, 159-171, 180-185, 189-209, 228-234, 245-262, 264-275, 280-302, 304-330, 343-360, 391-409, 432-437, 454-463, 467-474, 478-485, 515-528, 532-539, 553-567, 569-581, 586-592, 605-612, 627-635, 639-656, 671-682, 700-714, 731-747, 754-770, 775-791, 797-834, 838-848, 872-891, 927-933, 935-942, 948-968, 976-986, 1000-1007, 1029-1037, 630-700;
서열 번호 154의 aa 17-25, 27-55, 84-90, 95-101, 115-121, 55-101;
서열 번호 155의 aa 13-28, 40-46, 69-75, 86-92, 114-120, 126-137, 155-172, 182-193, 199-206, 213-221, 232-238, 243-253, 270-276, 284-290, 22-100;
서열 번호 158의 aa 7-19, 46-57, 85-91, 110-117, 125-133, 140-149, 156-163, 198-204, 236-251, 269-275, 283-290, 318-323, 347-363, 9-42, 158-174;
서열 번호 168의 aa 7-14, 21-30, 34-50, 52-63, 65-72, 77-84, 109-124, 129-152, 158-163, 175-190, 193-216, 219-234;
서열 번호 174의 aa 5-24, 38-44, 100-106, 118-130, 144-154, 204-210, 218-223, 228-243, 257-264, 266-286, 292-299;
서열 번호 176의 aa 29-44, 74-83, 105-113, 119-125, 130-148, 155-175, 182-190, 198-211, 238-245;
이들 단편 각각은 서로 독립적으로 본원 발명의 바람직한 측면을 형성한다.
이에 더하여, 특히 적합한 보조 에피토프가 이들 항원으로부터 유도될 수 있다. 특히 바람직한 보조 에피토프는 표 4와 5에서 “추정 항원성 표면 영역”에 언급된 펩티드 및 T-세포 에피토프인 Seq. ID No. 56의 6-40, 583-598, 620-646, 871-896, Seq ID No. 70의 aa 24-53, Seq. ID No. 74의 aa 240-260, Seq. ID No. 81의 aa 1660-1682, 1746-1790, Seq. ID No. 83의 aa 1-29, 680-709, 878-902, Seq. ID No. 89의 aa 96-136, Seq. ID No. 94의 aa 1-29, 226-269, 275-326, Seq. ID No. 114의 aa 23-47, 107-156, Seq. ID No. 142의 aa 24-53, 이들의 단편에서 선택되는 단편을 포함하는 펩티드이다.
다른 측면에서, 본원 발명은 스타필로코커스 아우레우스(S. aureus)와 스타필로코커스 에피데르미디스(S. epidermidis)에 대한 상기에 동정된 과다면역 혈청-반응성 항원 또는 이의 단편을 포함하는 백신에 관한다. 이런 백신은 스타필로코커 스 아우레우스(S. aureus) 또는 스타필로코커스 에피데르미디스(S. epidermidis)에 대한 한가지이상의 항원을 포함할 수 있다. 선택적으로, 이런 스타필로코커스 아우레우스(S. aureus) 또는 스타필로코커스 에피데르미디스(S. epidermidis) 항원은 복합 백신으로 다른 병원균에 대한 항원과도 결합될 수 있다. 적절하게는, 이런 백신은 면역촉진 물질, 적절하게는, 다가양이온 중합체, 특히 다가양이온성 펩티드, 면역촉진 데옥시뉴클레오티드(ODN), 신경활성 화합물, 특히 인간 성장 호르몬, 알루멘, 프레운드 완전 어쥬번트, 프레운드 불완전 어쥬번트, 또는 이들의 혼합물에서 선택된다. 이런 백신은 유전자조작된 미생물, 예를 들면, 대장균(E. coli)의 표면에서 표면 전시 단백질 플랫폼에 전시되는 항원을 포함할 수도 있다.
다른 측면에서, 본원 발명은 상기 규정된 스타필로코커스 아우레우스(S. aureus)와 스타필로코커스 에피데르미디스(S. epidermidis) 항원 및 이들의 항원 단편중 적어도 한가지에 대한 항체를 포함하는 특이적인 조성물에 관한다. 이들 항체는 바람직하게는, 단클론항체이다.
이런 항체 조성물(다클론 또는 단클론)을 생산하는 방법은 당업자에게 공지된 것이다. 이런 단클론 항체 조성물을 생산하는데 적합한 방법은 다음의 단계로 특성화된다:
- 상기 규정된 스타필로코커스(Staphylococcus) 항원 또는 이의 단편을 사람아닌 동물에 투여하여 상기 동물에서 면역반응을 유도하고,
- 상기 동물로부터 비장 또는 비장 세포를 떼어내고,
- 상기 비장 또는 비장 세포의 하이브리도마 세포를 만들고,
- 상기 항원에 특이적인 하이브리도마 세포를 선별 및 클론하고,
- 상기 클론된 하이브리도마 세포의 배양 및 선택적인 정제 단계로 항체 조성물을 생산한다.
적절하게는, 비장 또는 비장 세포를 떼어내는 단계는 동물을 죽이는 단계와 연계시킨다.
단클론 항체 또는 이의 단편은 키메라 또는 인화시켜(Graziano et al. 1995) 반복된 투여를 가능하게 할 수 있다. 대안으로, 인간 단클론 항체와 이의 단편은 파아지-전시 라이브러리(McGuinnes et al., 1996) 또는 외래유전자도입 동물(Bruggemann et al., 1996)로부터 수득할 수 있다.
본원 발명으로 동정된 스타필로코커스 아우레우스(S. aureus) 또는 스타필로코커스 에피데르미디스(S. epidermidis) 항원에 대한 다클론 항체 조성물을 생산하는데 적합한 방법은 다음의 단계로 특성화된다:
- 상기 규정된 스타필로코커스(Staphylococcus) 항원 또는 이의 단편을 사람아닌 동물에 투여하여 상기 동물에서 면역반응을 유도하고,
- 상기 동물로부터 항체 함유 체액을 이전하고,
- 상기 항체 함유 체액을 추가로 정제하여 항체 조성물을 생산한다.
이들 단클론이나 다클론항체 조성물은 스타필로코커스(Staphylococcus) 감염으로 인한 질환을 치료 또는 예방하는 약물의 제조에 사용될 수 있다. 또한, 이들은 진단과 화상 진단 목적으로 사용될 수도 있다.
신규한 스타필로코커스 아우레우스(Staphylococcus aureus) 항원의 발견
실시예
1: 인간 혈청으로부터 항체의 준비
인간 면역계에 의해 생산되고 인간 혈청에 존재하는 스타필로코커스(Staphylococcus)에 대한 항체는 항원성 단백질의 생체내 발현 및 이들의 면역원성을 지시한다. 이들 분자는 특정 항-스타필로코커스(Staphylococcus) 항체와 상응하는 스타필로코커스 아우레우스(Staphylococcus . aureus) 펩티드나 단백질의 상호작용에 기초하는 본원 발명과 같은 방식에서 개별 항원의 동정에 필수적이다. 적절한 항체 레퍼토리에 접근하기 위하여, 인간 혈청이 I. 급성 스타필로코커스 아우레우스(Staphylococcus . aureus) 감염, 예를 들면, 균혈증, 패혈증, 혈관내와 경피 카테터와 장치의 감염, 상처 감염, 표면과 심부 연조직 감염 환자로부터 수집되었다. 스타필로코커스 아우레우스(Staphylococcus. aureus)는 의학적 미생물학 검사에 의해 원인 물질로 밝혀졌다. Ⅱ. 감염되지 않은 성인으로부터 얻은 혈청 시료 수집물도 본 분석에 포함되었는데, 그 이유는 스타필로코커스(Staphylococcus) 감염이 일반적이고 항체가 피부와 연조직 감염(절창병, 상처 감염, 치주염 등)에서 스타필로코커스(Staphylococcus)와의 사전 조우로부터 자연 면역의 결과로 존재하기 때문이다.
혈청은 일련의 ELISA 분석으로 스타필로코커스 아우레우스(Staphylococcus . aureus) 항체에 대하여 특성화시켰다. 측정된 역가가 교차-반응성 항체의 합의 결과가 아님을 입증하기 위하여 여러 스타필로코커스(Staphylococcus) 항원을 사용되 었다. 이를 위하여, 전체 세포 스타필로코커스 아우레우스(Staphylococcus . aureus)(단백질 A 결핍) 추출물(상이한 조건에서 배양) 또는 전체 박테리아뿐만 아니라, 개별 세포 웰 구성요소, 예를 들면, 스타필로코커스 아우레우스(Staphylococcus. aureus)로부터 분리된 리포테이코산과 펩티도글리칸이 ELISA 분석에 사용되었다. 더욱 중요하게는, 본원에 따른 인간 혈청 수집물의 더욱 바람직한 특성화를 위하여, 공지된 스타필로코커스(Staphylococcus) 세포 표면 단백질을 대표하는 재조합 단백질 수집물이 확립되었다.
최근에, IgG뿐만 아니라 IgA 혈청 항체가 PMN의 FcRⅢ 수용체에 의해 인식될 수 있고 옵소닌화를 촉진할 수 있는 것으로 보고되었다(Phillips-Quagliata et al., 2000; shibuya et al., 2000). IgA 항체의 일차적인 역할은 주로 점막 표면에서 중화이다. 혈청 IgA 수준은 이합성 분비 IgA의 품질, 분량, 특이성을 반영한다. 이런 이유로, 혈청 수집물은 항-스타필로코커스(Staphylococcus) IgG 뿐만 아니라 IgA 수준에 대해서도 분석되었다. ELISA 분석에서 높은 친화성 유형의 항체, 예를 들면, IgG와 IgA를 검출하고 IgM을 회피하는데 매우 특이적인 이차 시약이 사용되었다. IgM 항체의 생산은 일차 적응성 체액 반응 동안 생성되고 낮은 친화성 항체를 결과하는 반면, IgG와 IgA 항체는 친화성 성숙을 이미 거쳤기 때문에 병을 억제하고 예방하는데 더욱 귀중하다.
실험 과정
효소-흡착성 면역 분석(ELISA). ELISA 평판은 코팅 완충액(탄산나트륨 pH 9.2)에서 2-10 ㎍/㎖ 상이한 항원으로 코팅하였다. 혈청의 연속 희석(100-100,000) 은 TBS-BSA에서 달성하였다. 매우 특이적인(교차-흡수된) HRP(양고충냉이 과산화효소)-표지된 항-인간 IgG 또는 항-인간 IgA 이차 항체(Southern Biotech)는 제조업자의 권고에 따라 사용하였다(~2,000x). 항원-항체 복합체는 자동화 ELISA 판독기(Wallace Victor 1420)에서 OD405nm 판독에 기초하여 기질(ABT)의 유색 산물로의 전환을 측정함으로써 정량하였다. 역가는 일정한 희석도에서 비교하였는데, 희석 반응은 선형이었다(표 1). ~100 혈청은 다중 스타필로코커스(Staphylococcus) 구성요소에 대한 반응성에 기초하여 분류하였는데, 최대 혈청(90 백분위수 이상)은 항원 동정에서 추가 분석을 위하여 선택되었다. 중요하게는, 임상적으로 건강한 개체의 혈청으로부터 유래된 항-스타필로코커스(Staphylococcus) 항체는 매우 안정한 것으로 확인되었고 3, 6, 9개월후 모든 스타필로코커스(Staphylococcus) 항원에 대하여 동일하게 높은 ELISA 역가를 제공하였다. 대조적으로, 환자에서 항-스타필로코커스 아우레우스(Staphylococcus . aureus) 항체는 감소하고, 이후 감염 수주후에 소멸되었다(Coloque-Navarro et al, 1998). 하지만, 환자로부터 얻은 항체는 매우 중요한데, 그 이유는 이들이 본원 발명에 따른 선별동안 ELISA로 검사되거나 또는 면역성으로 확인된 박테리아 항원의 생체내 발현의 직접적인 증거이기 때문이다.
항체 특성화동안 추구되는 이런 포괄적인 접근방식은 독특하고 항-스타필로코커스(Staphylococcus) 과다면역 혈청의 명확한 동정을 결과한다.
게놈 선별을 위한 항체의 정제. 환자 및 감염되지 않은 개체군으로부터 얻은 5개의 혈청은 전체적인 스타필로코커스(Staphylococcus) 역가에 기초하여 선택되었 다. 대장균(E. coli)에 대한 항체는 전체 세포 대장균(E. coli)(DH5a, pHIE11로 형질전환, 박테리아 전시에 이용된 조건과 동일한 조건에서 배양)과 함께 열 불활화된 혈청을 배양하거나 또는 대장균(E. coli) 용해질 친화성 크로마토그래피로 제거하였다. 모아진 고갈된 혈청으로부터 매우 진한 IgG 조제물은 제조업자(UltraLink Immobilized Protein G. Pierce)의 권고에 따른 단백질 G 친화성 크로마토그래피로 만들었다. IgA 항체 역시 스트렙타비딘-아가로즈(GIBCO BRL)에 고착된 비오틴-표지된 항-인간 IgA(Southern Biotech)을 사용한 친화성 크로마토그래피로 정제하였다. 고갈과 정제의 효율은 SDS-PAGE, 웨스턴 블랏팅, ELISA, 단백질 농도 측정으로 검사하였다. 프로테오믹스에서는 IgG과 IgA 조제물의 고갈이 필요하지 않은데, 그 이유는 2차 시약이 특이성을 담보하기 때문이다.
실시예 2: 스타필로코커스 아우레우스( Staphylococcus. aureus )의 고도 무작위 프레임-선택된 소형-단편 게놈 DNA 라이브러리의 산출
실험 과정
스타필로코커스(Staphylococcus) 게놈 DNA의 준비. 이 방법은 2가지의 이미 공개된 프로토콜(Sohail, 1998, Betley et al, 1984)의 변형으로 개발되었는데, 높은 품질과 대규모로 게놈 DNA를 얻기 위하여 메티실린 저항성 스타필로코커스 아우레우스(Staphylococcus . aureus) 균주 COL에 맞게 특이적으로 수정되었다. 5 ㎍/㎖ 테트라사이클린으로 보충된 500 ㎖ BHI(Brian Heart Infusion) 배지는 동결된 스탭(stab)의 박테리아를 접종하고 통기하면서 배양하고 37℃에서 18시간동안 교반하였다. 이후, 배양액은 2개의 각 250 ㎖ 부분시료에 수집하고 15분 동안 1600 x g로 원심분리하며, 상층액은 제거하였다. 박테리아 펠릿은 26 ㎖의 0.1 mM Tris-HCl, pH 7.6에 조심스럽게 재-현탁시키고 15분 동안 1600 x g로 한번 더 원심분리하였다. 펠릿은 20 ㎖의 1 mM Tris-HCl, pH 7.6, 0.1 mM EDTA에 재-현탁시키고 무균 50 ㎖ 폴리프로필렌 튜브로 옮겼다. 1 ㎖의 10 ㎎/㎖ 열 처리된 RNase A와 200 U RNase T1을 각 튜브에 첨가하고, 용액은 조심스럽게 혼합하였다. 이후, 250 ㎕ 리소스타핀(lysostaphin)(10 ㎎/㎖ 원료, ddH2O에 새로이 준비)을 튜브에 첨가하고 완전히 혼합하고 지속적인 교반하에 진탕 수조에서 40℃에서 10분 동안 배양하였다. 1 ㎖의 10% SDS, 40 ㎕ 프로테이나제 K(25 ㎎/㎖ 원료)와 100 ㎕ 프로나제(10 ㎎/㎖)의 첨가후, 튜브는 수회 뒤집고 40℃, 진탕 수조에서 5분 동안 배양하였다. 이후, 3.75 ㎖의 5M NaCl과 2.5 ㎖ 세틸 트리메틸-암모늄 불화물 용액(CTAB)(10% w/v. 4% w/v NaCl)을 첨가하고, 튜브는 65℃, 진탕 수조에서 추가로 10분 동안 배양하였다. 시료는 실온으로 냉각시키고 PhOH/CHCl3/IAA(25:24:1)와 CHCl3/IAA(24:1)로 추출하였다. 수상은 조심스럽게 수집하고 새로운 무균 50-㎖ 튜브로 옮겼다. 각 튜브에 1.5 ㎖ StraracleanTM 수지를 첨가하고 부드럽지만 완전하게 혼합하며 실온에서 1분 동안 배양하였다. 시료는 원심분리하고, DNA를 함유하는 상층은 깨끗한 50 ㎖-튜브로 수집하였다. DNA는 0.6 x 부피의 이소프로판올을 첨가하여 실온에서 침전시키고 무균 Pasteur 피펫으로 상기 용액으로부터 스풀(spool)하며 80% 차가운 에탄올을 함유하는 튜브로 옮겼다. DNA는 10-12,000 x g로 침전물을 원심분리하여 수집하고, 이후 대기 건조시키고 ddH2O에 용해시켰다.
소규모 게놈 DNA 단편의 준비. 게놈 DNA 단편은 컵-호른(cup-horn) 초음파처리장치(BB5 컵 호른이 구비된 Bandelin Sonoplus UV 2200 초음파처리장치, 100% 파워 출력에서 10 sec. 펄스)로 150 내지 300 bp 크기의 단편으로 또는 적절한 DNase I 처리(Novagen)로 50 내지 70 bp 크기의 단편으로 기계적으로 전단하였다. 초음파처리는 DNA를 150-300 bp 크기의 단편으로 깨뜨릴 때 훨씬 밀집된 단편 크기 분포를 산출하는 것으로 확인되었다. 하지만, 초음파-유도된 유체역학적 전단력에 대한 DNA의 광범위한 노출에도 불구하고, 단편 크기에서 후속적인 감소가 효율적이고 재현적으로 달성되지 않았다. 따라서, Novagen의 샷건 절단 키트를 이용한 적절한 DNase I 처리로 50 내지 70 bp 크기의 단편을 얻었다. 이런 키트에 제공되는 1:20 희석된 DNase I을 준비하고, 60 ㎕ 부피의 MnCl2 존재하에 20℃에서 5분 동안 절단을 실시하여 효소에 의한 이중-가닥 절단을 담보하였다. 반응은 2 ㎕의 0.5M EDTA로 중단시키고, 단편 효율은 2% TAE-아가로즈 겔에서 평가하였다. 이런 처리는 게놈 DNA의 거의 50-70 bp 단편으로의 전체적인 단편화를 결과하였다. 이후, 단편은 각 100 μM dNTP의 존재하에 T4 DNA 중합효소로 2회 평활-말단화시켜 말단의 효율적인 수세(flushing)를 담보한다. 단편은 결찰 반응에 즉시 사용하거나 또는 후속 사용을 위하여 -20℃로 동결하였다.
벡터의 설명. 벡터 pMAL4.1은 카나마이신 저항성 유전자를 보유하는 pEH1 골격(Hashemzadeyh-Bonehi et al., 1998)에 작제하였다. 게다가, 상기 벡터는 다중 클로닝 부위에 클론된 b-락타마제(bla) 유전자를 보유한다. 세포질 막에서 효과적 인 분비를 담보하기 위하여, bla 유전자의 앞에 ompA 리더 펩티드 서열을 위치시킨다. Sma I 제한 부위는 라이브러리 삽입에 적합하다. Sma I 부위의 측면에는 상류의 FesI 부위와 하류의 NotI 부위가 위치하는데, 이들은 선별된 단편의 회수에 이용된다. ompA 리더 서열이후에 3개의 제한 부위를 삽입하여, bla 유전자가 -1 개방 해독틀에서 전사되면 NotI 부위이후 15 bp에 종결 코돈이 생성되도록 한다. +1 bp 삽입은 bla ORF를 복구시켜, 앰플리신 저항성의 결과적 획득으로 b-락타마제 단백질이 생성되도록 한다.
벡터 pMAL4.31은 b-락타마제 유전자가 카나마이신 저항성 유전자로 치환된 pASK-IBA 골격(Skerra, 1994)에 작제하였다. 게다가, 상기 벡터는 다중 클로닝 부위에 클론된 b-락타마제(bla) 유전자를 보유한다. 세포질 막에서 효과적인 분비를 담보하기 위하여, 성숙 b-락타마제를 인코드하는 서열의 앞에 ompA 리더 펩티드 서열을 위치시킨다. 더욱이, 성숙 b-락타마제의 첫 12개 아미노산을 인코드하는 서열(스페이서 서열)은 ompA 리더 펩티드 서열을 후행하여 리더 펩티드 절단 부위 직후에 서열의 융합을 회피하는데, 그 이유는 이 영역에서 양성 아미노산의 클러스트가 세포질 막을 통한 이동을 감소 또는 제거하기 때문이다(Kajava et al., 2000). A Sma I 제한 부위는 라이브러리 삽입에 적합하다. Sma I 부위의 측면에는 상류의 FesI 부위와 하류의 NotI 부위가 위치하는데, 이들은 선별된 단편의 회수에 이용된다. 12개의 아미노산 스페이서 서열을 인코드하는 서열이후에 3개의 제한 부위를 삽입하여, bla 유전자가 -1 개방 해독틀에서 전사되면 NotI 부위이후 15 bp에 종결 코돈이 생성되도록 한다. +1 bp 삽입은 bla ORF를 복구시켜, 앰플리신 저항성의 결 과적 획득으로 b-락타마제 단백질이 생성되도록 한다.
벡터 pMAL9.1은 lamB 유전자를 pEH1의 다중 클로닝 부위에 클론시켜 작제하였다. 후속으로, 제한 부위 FseI, SmaI, NotI을 포함하는 서열을 lamB에서 154번 아미노산 뒤에 삽입하였다. 이런 삽입을 위한 개방 해독틀은 플라스미드 pMAL4.1 또는 pMAL4.31에서 플라스미드 pMAL9.1까지 FseI과 NotI 절단에 의해 절제되는 프레임-선별된 DNA 단편의 이동이 lamB와 개별 삽입체의 지속적인 개방 해독틀을 산출하도록 하는 방식으로 선택되었다.
벡터 pHIE11은 fhuA 유전자를 pEH1의 다중 클로닝 부위에 클론시켜 작제하였다. 후속으로, 제한 부위 FseI, Xbal, NotI을 포함하는 서열을 fhuA에서 405번 아미노산 뒤에 삽입하였다. 이런 삽입을 위한 개방 해독틀은 플라스미드 pMAL4.1 또는 pMAL4.31에서 플라스미드 pHIE11까지 FseI과 NotI 절단에 의해 절제되는 프레임-선별된 DNA 단편의 이동이 fhuA와 개별 삽입체의 지속적인 개방 해독틀을 산출하도록 하는 방식으로 선택되었다.
프레임 선별을 위한 라이브러리의 클로닝과 평가. 게놈 스타필로코커스 아우레우스(Staphylococcus . aureus) DNA 단편은 벡터 pMAL4.1 또는 pMAL4.31의 SamI 부위에 결찰시켰다. 재조합 DNA는 DH10B 전기콤피던트(electrocompetent) 대장균(E. coli) 세포(GIBCO BRL)로 전기천공(electroporation)시키고, 형질전환체는 카나마이신(50㎍/㎖)과 앰피실린(50㎍/㎖)으로 보충된 LB-아가에 도말하였다. 평판은 37℃에서 하룻밤동안 배양하고, 콜로니는 대규모 DNA 추출을 위하여 수집하였다. 대표 평판은 콜로니 PCR 분석과 대규모 서열분석을 위한 콜로니를 수집하기 위 하여 안전하게 보관한다. 간단한 콜로니 PCR 분석을 이용하여 대략적인 단편 크기 분포 및 삽입 효율을 처음에 측정하였다. 서열분석 데이터로부터 정확한 단편 크기, 삽입 부위에서 접합 무손상, 프레임 선별 정확도(3n+1 규칙)를 평가하였다.
박테리아 표면 전시를 위한 라이브러리의 클로닝과 평가. 게놈 DNA 단편은 제한 효소 FseI과 NotI으로 스타필로코커스 아우레우스(Staphylococcus . aureus) 라이브러리를 보유하는 벡터 pMAL4.1 또는 pMAL4.31로부터 절단하였다. 이후, 단편의 전체 집합은 제한 효소 FseI과 NotI으로 절단된 플라스미드 pMAL9.1(LamB) 또는 pHIE11(FhuA)에 이전하였다. 8 bp GC 풍부한 서열을 인식하는 이들 2가지 제한 효소를 사용하여, 벡터 pMAL4.1 또는 pMAL4.31에서 선택된 개방 해독틀은 각 플랫폼 벡터에 유지시킨다. 이후, 플라스미드 라이브러리는 전기천공으로 대장균(E. coli) DH5a 세포에 형질전환시켰다. 세포는 50 ㎍/㎖ 카나마이신으로 보충된 대형 LB-아가 평판에 도말하고 분명하게 나타나는 단일 콜로니를 산출하는 밀도로 37℃에서 하룻밤동안 배양하였다. 이후, 세포는 이들 평판의 표면으로부터 긁어모으고 새로운 LB 배지로 세척하며 라이브러리 선별을 위한 부분시료로 -80℃에 보관하였다.
결과
프레임 선별을 위한 라이브러리. 2가지 라이브러리(LSA50/6와 LSA250/1)는 각각 대략 50과 250 bp 크기의 pMAL4.1 벡터에서 발생되었다. 양 라이브러리에서, 대략 1 ㎍ pMAL4.1 플라스미드 DNA와 50 ng 단편화된 게놈 스타필로코커스 아우레우스(Staphylococcus . aureus) DNA를 사용하여 프레임 선별후 총 1-2x106개의 클론 이 달성되었다. LSA50/6 라이브러리의 임의성(randomness)을 평가하기 위하여, 672개의 무작위로 선택된 클론을 서열분석하였다. 생물정보학적 분석에서 이들 클론중에서 1회 이상 나타나는 클론은 없는 것으로 밝혀졌다. 또한, 이들 클론의 90%가 19 내지 70 bp의 크기 범위(25 bp의 평균 크기)에 포함되는 것으로 밝혀졌다(도 2). 672개 서열 모두 3n+1 규칙을 따랐는데, 이는 모든 클론이 적절하게 프레임 선별되었음을 암시한다.
박테리아 표면 전시 라이브러리. 대장균(E. coli)의 표면에서 펩티드의 전시는 프레임 선별 벡터 pMAL4.1에서 전시 플라스미드 pMAL9.1(LamB) 또는 pHIE11(FhuA)까지 LSA50/6 라이브러리로부터 삽입체의 전달을 필요로 하였다. 게놈 DNA 단편은 FseI와 NotI 제한으로 절단하고, 0.1 ㎍ 플라스미드 DNA를 갖는 5 ng 삽입체의 결찰은 2-5x106 클론을 결과하였다. 상기 클론은 LB 평판에서 긁어모으고 추가 증폭없이 동결시켰다.
실시예 3: 박테리아 표면 전시된 게놈 라이브러리와 인간 혈청을 이용하여 스타필로코커스 아우레우스(Staphylococcus. aureus)로부터 고도 면역성 펩티드 서열의 동정
실험 과정
MACS 선별. 일정한 라이브러리로부터 대략 2.5x108 세포는 50 ㎍/㎖ 카나마이신으로 보충된 5 ㎖ LB-배지에 37℃에서 2시간동안 배양하였다. 발현은 30분 동안 1 mM IPTG를 첨가하여 유도하였다. 세포는 새로운 LB 배지로 2회 세척하고, 대 략 2x107 세포는 100 ㎕ LB 배지에 재-현탁시키고 Eppendorf 튜브로 옮겼다.
10 ㎍ 비오틴화된 인간 혈청을 세포에 첨가하고, 현탁액은 부드럽게 교반하면서 4℃에서 하룻밤동안 배양하였다. 900 ㎕ LB 배지를 첨가하고, 현탁액은 혼합하고, 이후 4℃에서 10분 동안 6000 rpm으로 원심분리하였다. 세포는 1 ㎖ LB로 한번 더 세척하고, 이후 100 ㎕ LB 배지에 재-현탁시켰다. 스트렙타비딘에 결합된 10 ㎕ MACS 마이크로비드(Miltenyi Biotech, Germany)를 첨가하고, MACS 마이크로비드 세포 현탁액은 자석에 고정된 평형화 MS 칼럼(Miltenyi Biotech, Germany)에 적하하였다(MS 칼럼은 1 ㎖ 70% EtOH로 1회, 2 ㎖ LB 배지로 2회 세척하여 평형화시켰다)
이후, 칼럼은 3 ㎖ LB 배지로 3회 세척하였다. 용리는 자석을 제거하고 2 ㎖ LB 배지로 세척하여 실시하였다. 3 ㎖ LB 배지로 칼럼을 세척한 이후, 2 ㎖ 용출액은 동일 칼럼에 2차 적하하고, 세척과 용리 과정을 반복하였다. 적하, 세척, 용리 과정은 3차로 실시하여, 2 ㎖ 최종 용출액을 결과하였다.
2차 선별은 다음과 같이 실시하였다. 최종 용출액의 세포는 원심분리로 수집하고 50 ㎍/㎖ 카나마이신으로 보충된 1 ㎖ LB 배지에 재-현탁시켰다. 배양액은 37℃에서 90분 동안 배양하고, 이후 1 mM IPTG로 30분 동안 유도하였다. 후속으로, 세포는 수집하고 1 ㎖ LB 배지로 1회 세척하며 10 ㎕ LB 배지에 현탁시켰다. 부피가 감소하기 때문에 1 ㎍의 비오틴화된 인간 혈청을 첨가하고, 현탁액은 부드럽게 교반하면서 4℃에서 하룻밤동안 배양하였다. 모든 다른 단계는 1차 선별에서와 동 일하였다. 2차 선별후 선별된 세포는 50 ㎍/㎖ 카나마이신으로 보충된 LB-아가 평판에 도말하고 37℃에서 하룻밤동안 배양시켰다.
서열분석 및 웨스턴 블랏 분석에 의한 선별된 클론의 평가. 선별된 클론은 50 ㎍/㎖ 카나마이신으로 보충된 3 ㎖ LB 배지에서 37℃에 하룻밤동안 배양하여 표준 과정으로 플라스미드 DNA를 준비하였다. 서열분석은 MWG(Germany)에서 또는 TIGR(U.S.A)와 협력하여 실시하였다.
웨스턴 블랏 분석을 위하여 대략 10 내지 20 ㎍ 세포 단백질은 10% SDS-PAGE로 분리하고 HybondC 막(Amersham Pharmacia Biotech, England)에 블랏하였다. LamB 또는 FhuA 융합단백질은 1:5000 희석된 인간 혈청을 일차 항체로, 1:5000 희석되고 HRP에 결합된 항-인간 IgG 항체를 이차 항체로 하여 검출하였다. 검출은 ECL 검출 키트(Amersham Pharmacia Biotech, England)로 실시하였다. 대안으로, 토끼 항-FhuA 또는 생쥐 항-LamB 항체가 융합단백질의 검출을 위한 HRP에 결합된 개별 이차 항체와 함께 일차 항체로 사용되었다.
결과
비오틴화된 인간 혈청을 이용하여 자성 활성화된 세포 분류(MACS)에 의해 세균 표면 전시 라이브러리의 서열화를 하였다. pMAL9.1에 있는 LSA50/6과 pHIE11에 있는 LSA250/1은 비오틴화된 인간 환자 혈청액으로 선별하였다(실시예 1: 인간 혈청으로부터 항체 준비 참고). 선별과정은 실험 과정에서 설명하는 것과 같이 실행하였다. 기준으로는 스타필로코커스 아우레우스(S. aureus)로 대부분 감염이 안된 유아들의 혈청액을 이용하였다. 설명한 조건하에서, 유아 혈청과 비교하여 환자에 서 10 내지 50배 더 많은 세포를 지속적으로 선별하였다(도 3). 선별 효능을 평가하기 위해, 약 100개의 선별된 클론을 무작위로 선택하여, 동일한 환자 혈청으로 웨스턴 블랏 분석을 하였다. 이 분석으로 선택된 클론의 30 내지 50%에서 환자 혈청에 있는 항체에 반응성을 보인 반면에 스타필로코커스 아우레우스(S. aureus) 특정 삽입체가 없는 LamB 또는 FhuA을 발현시키는 기준 균주는 동일한 혈청과 반응을 하지 않았다. 콜로니 PCR 검사에서도 모든 선택된 클론에는 예상 크기 범위의 삽입체를 포함하였다.
무작위로 선택된 클론(스크린당 500 내지 800개) 대다수를 서열화하면 선별에 이용된 인간 환자 혈청에 의해 특이적으로 인지되는 유전자, 이에 상응하는 펩티드 또는 단백질 서열을 확인하였다. 선택된 특정 클론의 반도는 이들 클론에 의해 나타나는 에피토프를 선별하고 인지하는데 이용된 혈청내에 특정 항체의 풍부함 및 친화성을 어느 정도 나타낸다. 이에 대해, 일부 클론(ORF2264, ORF1951, ORF0222, 리파제 및 IsaA)은 90배까지 선택되는데, 이는 이들의 높은 면역원성을 나타낸다. 표 2에 제시한 모든 클론은 단일 클론의 전체 세포 추출물을 이용한 웨스턴 블랏 분석으로 증명되어, 스크린에 이용된 인간 혈청액의 지적한 반응성을 나타낸다. 추가 주목할 것은 스타필로코커스 아우레우스(S. aureus)의 표면에 부착된 또는 분비되는 단백질을 세균성 표면 전시 스크린에 의해 확인되는 유전자 대부분이 인코드한다는 것이다. 이는 스타필로코커스 아우레우스(S. aureus)의 독성에 표면 부착된 또는 분비된 단백질의 예상 역할에 따른다.
상이한 인간 혈청으로 면역원성이 높은 펩티드 서열의 반응성 평가. 10 내지 30개의 다른 인간 환자 혈청은 본원 발명에 따른 스크린에서 발견된 선별된 면역원성 펩티드 서열에 대한 항체가 존재하는지를 평가하였다. 대장균에 의해 발현되는 단백질과의 교차 반응 가능성을 배제하기 위해, 모든 혈청은 FhuA 단백질을 발현하는 대장균 DHa 세포의 전체 세포 용해물질에 선-흡착시켰다.
이와 같은 분석은 표 2에 요약하였고, 도 4에서 볼 수 있으며, 현재 스크린의 유효성을 나타내는 것이다. 짧은 선택된 에피토프는 대다수 환자에서 항체 생산을 유도한다는 것을 볼 수 있다(ORF1618, ORF1632, IsaA, Empbh, 단백질 A). 더 큰 환자의 혈청 세트에 의해 인지되지 않는 이들 펩티드 서열은 매우 면역원성이 큰 단백질 부분일수는 있지만, 재조합 단백질 자체는 각 개별 경우에 대해 그 목적에 따라 시험을 한다.
실시예 4: 리보솜 전시 및 인간 혈청을 이용하여 스타필로코커스 아우레우스(S. aureus)로부터 게놈 단편의 매우 면역원성이 큰 펩티드 서열 동정
실험 과정
리보솜 전시 선별: 상기에서 설명한 것과 같이, pMAL4.1에 있는 스타필로코커스 아우레우스(S. aureus) LSA250/1로부터 게놈 라이브러리 2.4ng을 올리고 ICC277 및 ICC202로 PCR 증폭시켜, 리보솜 전시에 이용한다. 올리고 ICC277 (CGAATAATACGACTCACTATAGGGAGACCACAACGGTTTCCCACTAGTAATAATTTTGTTTAACTTTAAGAAGGAGATATATCCATGCAGaCCTTGGCCGGCCTCCC); 그리고 ICC202 (GGCCCACCCGTGAAGGTGAGCCGGCGTAAGATGCTTTTCTGTGACTGG)는 각각 플라스미드 pMAL4.1의 5' 및 3' Fse I-Not I 삽입 부분에 혼성화시킨다. ICC277을 T7 파아지 RNA 중합 효소 프로모터, 팔린드롬 서열에 도입시키면, RNA 수준에서 ATG 시작 코돈을 포함하는 T7 파아지의 유전자 10의 해독 개시와 리보솜 결합 부위(RBS)에 줄기형 루프 구조가 형성된다.
올리고 ICC202는 β-락타마제 개방 해독틀의 뉴클레오티드 위치 668에 혼성화시키고, 또한 생성된 RNA의 3' 말단에 줄기형 루프 구조를 도입시킨다. PCR은 50℃ 혼성화 반응 온도에서, 25회 동안 충실성이 높은 PCR 키트(Roche Diagnostic)를 이용하여 실행하고, 다른 조건은 표준 조건에 준한다.
생성된 PCR 라이브러리는 기존에 보고된 것(Hanes et al., 1997)과 유사한 방식으로 단, 하기에서 기재된 정도의 변형을 하여 리보솜 전시에 의해 5회 연속 선별 및 증폭에 이용하였다.
리보솜 전시의 1라운드는 다음의 단계를 포함한다:
2㎍ PCR 생성물을 RiboMax kit(Promega)로 시험관내 전사시키면 ca. 50㎍ A가 생성된다. 시험관내 전사는 4.4㎕ Premix Z(250mM 트리스-아세테이트 pH7.5, 각 아미노산 1.75mM, 10mM ATP, 2.5 mM GTP, 5 mM CAMP, 150mM 아세틸포스페이트, 2.5㎎/㎖ 대장균(E. coli) tRNA, 0.1㎎/㎖ 폴린산, 7.5% PEG 8000, 200mM 글루타메이트 칼슘, 13.8 mM Mg(Ac)2, 8㎕ S30 추출물(x ㎎/㎖), 용액 내에서 시험관내 전사된 RNA 약 2㎍) 약 22㎕로 37℃에서 9분간 실시하였다. S30 추출물은 Chen et al., 1983에서 설명하는 것과 같이 준비하였다. 그 다음, 샘플을 얼음으로 냉각시킨 튜브로 옮기는데, 튜브에는 35.2㎕ 10% 우유-WBT(TRIS-아세테이트 pH 7.5, 150mM NaCl, 50mM Mg(Ac)2, 0.1% Tween-20, 10% 우유 분말) 및 52.8㎕ WBTH(상기 설명된 것에 추가로 2.5㎎/㎖ 헤파린포함)을 포함하고 있다. 연속하여, 10㎍ 정제된 IgG를 추가하고, 얼음위에서 90분 동안 놓아둔 후에, 30㎕ MAGmol 단백질 G 비드(Milenyi Biotec, 90분간 얼음위에)를 첨가하여, 면역 침전시킨다. 시료는 사전-균질화시킨후 얼음으로 냉각시킨 WBT 완충액으로 5회 씻어낸 μ 칼럼(Miltenyi Biotec)에 얹는다. 그 다음, 20㎕ EB20 용출 완충액(50mM TRIS-아세테이트, 150mM NaCl, 20mM EDTA, 50㎍/㎖ 사카로마이세스 세르비시아(S. cerevisiae) RNA)을 칼럼에 넣고, 4℃에서 5분간 둔다. 2 x 50 ㎕ EB20을 첨가하여 용출을 완료시킨다. 용출 시료에서 얻은 mRNA는 고순도 RNS 분리 키트(Rochen Diagnostics)를 이용하여 정제시킨다. 역전사를 제조업자의 지시에 따라 Superscript II 역 전사 키트에서(Rochen Diagnostics) 50℃에서 1시간동안 50㎕ 용적에서 60pmol 올리고 ICC202와 함께 역전사를 실시하였다. 이 혼합물 5㎕를 이용하여 상기에서 설명하는 것과 같이 프라이머 ICC202 및 ICC277로 다음과 같이 PCR을 한다.
리보솜 전시 3라운드를 실시하였고, 생성된 선택된 PCR 용액은 제한효소 NotI 및 FseI를 이용하여 절단함으로써 pHIE11(상기에서 설명)로 클론시킨다.
서열화 및 펩티드-ELISA 분석으로 선택된 클론의 평가: 선택된 클론은 37℃에서 3㎖ LB 배지(50㎍/㎖ 카나마이신이 보충됨)상에서 생장시켜, 표준과정에 따라 플라스미드 DNA를 준비하였다. 서열화 과정은 MWG(Germany) 또는 Institute of Genomic Research(TIGR; Rockville, MD, U.S.A)에서 실시하였다. 삽입체에 상응하 는 펩티드를 합성하고, 96 웰 미소적정판(Nunc)상에 10mM NaHCO3 pH 9.3으로 10㎍/㎖(50㎍)농도로 피복시킨다. 1% BSA/PBS를 이용하여, 37℃에서 차단시킨 후에, 언급한 혈청은 1:200 및 1:1000 희석비로 1% BSA/PBS를 이용하여 희석시키고, 웰에 넣는다. PBS/0.1% Tween-20으로 씻어낸 후에, 비오틴-표지된 항-인간 IgG 2차 항체(SBA)를 첨가하고, 표준과정에 따라 양고추냉이 과산화효소-결합된 스트렙타비딘을 첨가하여 감지할 수 있다.
결과
상기에서 설명한 것과 같은 250-bp 게놈 라이브러리(LSA250/1)를 이용하여 선별한다. 상기에서 설명한 것과 같이, 감염은 되지 않았지만 스타필로코커스 아우레우스(S. aureus)에 대해 높은 역가를 가지는 정제된 IgGs를 이용하여 항원성 펩티드를 선별하였다.
실험과정에 따라 리보솜 전시 선별 및 증폭 3라운드를 실행하였다; 생성된 PCR 용액을 클로닝하고 서열화시켜 완료한다.
다수(700개)의 무작위로 선별된 클론의 서열 분석으로 선별에 이용된 고역가 혈청에 의해 특이적으로 인지되는 유전자 및 이에 상응하는 펩티드 또는 단백질 서열을 확인하였다. 선택된 특정 클론의 빈도는 이들 클론에 의해 제시되는 에피토프 선택 및 인지에 이용된 혈청내에 특정 항체의 일부 빈도 및 친화성을 반영한다. 놀라운 것은, 일부 클론(ORF)은 50배까지 선별되었고, 이는 이들의 높은 면역원성 성질을 나타내는 것이다. 표 2는 ORF 이름, 서열 번호, 본원 발명의 스크린에 의해 확인된 횟수를 나타낸다.
다수의 면역-선별된 ORF를 위해, 확인된 면역원성 부분에 상응하는 펩티드를 합성하고, 확인된 혈청 용액 및 스타필로코커스 아우레우스(S. aureus)에 감염되어 고통을 받는 환자로부터 얻은 다수의 추가 혈청에 대해 이들의 반응성은 펩티드-ELISA에서 검사하였다. 도 5에 있는 그래프의 2개 시료에서는 아우레오리신 및 Pls에서 펩티드 값을 나타낸다. 이들은 고역가 혈청액에 대해 과다면역 반응성을 가질 뿐만 아니라 개별 환자의 혈청에 대해서도 과다면역 반응성을 나타낸다. 선택된 면역원성 부분에 상응하는 합성된 모든 펩티드는 고역가 혈청액에 대해 반응성을 보이고, 표 2에서는 상기에서 설명한 것과 같이, 개별 환자 혈청에 대해 반응성을 보이는 횟수를 나타낸 것이다.
또한, 상기에서 설명한 것과 같이 세균성 표면 전시에 의해서도 확인된 이들 ORF의 경우에는 ORF 내에 실제 면역원성 부분이 리보솜 전시에 의해 확인되는 것과 동일하거나 겹쳐진다는 것이 놀라운 일이다. 표 2에서는 이를 비교하였다.
실시예 5: 혈청학적 프로테옴 분석을 이용한 스타필로코커스 아우레우스( S. aureus)에서 매우 높은 면역원성 항원의 동정
매우 면역원성이 높은 항원 스타필로코커스 아우레우스(S. aureus) 균주 COL(Shafer and Iandolo, 1979) 및 아가-(Recsei et al., 1986)를 포함하는 스타필로코커스 아우레우스(S. aureus)로부터 얻은 표면 단백질 준비물은 -80℃에 글리세롤 원액에 또는 4℃ BHI (DIFCO) 평판 상에 보관한다. 단일 클론을 이용하여 BHI(“표준 조건”) 또는 RPMI 1640(GibcoBRL)에서 하룻밤 배양 접종물에 이용하 고, o/n과 이미노디아세트산(Sigma)으로 처리함으로써 철(“스트레스 조건”)로 방혈시킨다. 새로운 배지에 그 다음날 1:100으로 접종시키고, 세균은 O.D.600에서 0.3 내지 0.7이 되도록 생장시킨다. 세균은 원심분리를 이용하여 수득하고, 얼음으로 냉각된 PBS로 세척하였다. 표면 단백질은 리소스타핀으로 등장성 조건(Lim et al. 1998)하에서 처리하여 준비하였다. 간략하게 설명하면, ~3x109개 세균(O.D.600 =1은 약 5x107개 세균)을 35% 라피노즈(Aldrich Chemical Company), 프로테아제 저해물질(Roche), 5U 라이소스타핀(Sigma)을 포함하는 1㎖ 절단 완충액에 재현탁시킨다. 37℃에서 30분간 배양시킨 후에, 원형질은 저속 원심분리를 이용하여 조심스럽게 침강시킨다. 이와 같은 처리를 함으로써 상층액에 펩티도글리칸 세포벽의 펜타글리신 다리에 공유결합된 표면 단백질을 유리시킬 수 있다(Crossley, 1997). 세포 표면 단백질은 메탄올/클로로포름(Wessel, 1984)으로 침전시키거나 원심분리성 필터-튜브(Millipore)로 농축시킨다. 단백질 시료는 냉동시키고, -80℃에 보관하거나 시료 완충액에 용해시키고, 등전성 포커스(IEF)에 바로 사용한다(Pasquali et al. 1997).
스타필로코커스 아우레우스(S. aureus)에서 준비된 표면 단백질 조제물의 혈청학적 프로테옴 분석. 시료는 a) “스트레스 조건”하에서 생장된 스타필로코커스 아우레우스(S. aureus)/agr; b) “표준 조건”하에서 생장된 스타필로코커스 아우레우스(S. aureus)/COL; c) “스트레스 조건”하에서 스타필로코커스 아우레우 스(S. aureus)/COL로부터 획득하였다. “in-gel-reswelling 과정”(Pasquali et al., 1997)을 이용하여, 고정된 pH 농도차(pH 4-7, BioRad)를 포함하는 17㎝ 스트립 상에 로딩하였다. 블랏팅을 위한 겔에 100-800㎍ 단백질을 로딩하고, 예비 겔에는 400-1,000㎍ 단백질을 로딩한다. 등전성 포커싱 및 SDS-PAGE(9-16% 농도차 겔)는 Pasquali et al., 1997에서 설명하는 것과 같이 실행하였다. 웨스턴 블랏팅을 위해, 단백질은 반-건조 블랏팅을 이용하여 PVDF-막(BioRad)으로 옮긴다. 차단 후에(PBS/0.1% Tween 20, 10 건유, 4℃, 16h) 블랏은 혈청(1:2,500-1:100,000으로 차단용액으로 희석함, 표 3참고)과 함께 2시간 동안 배양한다. 세척후에, 혈청 IgG의 특정 결합은 2차 항체로 염소-항-사람-IgG/과산화효소 결합물(1:25,000, Southern Biotech)을 이용하면 눈으로 확인할 수 있고, 화학적발광 기질을 이용하여 현상할 수 있다(ECLTM, Amersham). 도 6에서 대표적인 결과를 확인할 수 있다. 30분간 50-65℃에서 2% β-ME/Laemmli 완충액으로 처리하면, 막을 벗길 수 있고, 바로 다른 혈청으로 다시 프로브시키고, 상기에서 설명하는 것과 같이 현상시킨다. 이와 같은 과정을 5회 반복하였다. 환자 또는 건강한 기증자 혈청에서는 신호가 나타나지만 유아 혈청액에서는 나타나지 않는데, 이는 코마시(BioRad)로 착색된 예비 겔(도 7에 샘플을 나타냄)과 일치한다. 스타필로코커스 아우레우스(S. aureus)의 표면 단백질 준비물의 이와 같은 혈청학적 프로테움 분석 결과를 표 3에서 요약하였다.
펩티드-핑거프린트 MALSI-TOF-MS 및 무작위 MS/MS에 의한 단백질 반점의 서열화. 겔 조각들을 번갈아 10㎕ 절단 완충액(10mM NH4HCO3/CAN, 1:1)으로 3회 세척 한다. 그 다음, 겔 조각은 10㎕ ACN으로 쪼그라들게 한 후, 2㎕ 프로테아제 용액(0.5㎍/㎕ 트립신, Promega, Madison, USA)으로 재팽창시킨다. 37℃에서 10-12시간동안 절단시킨다. MALDI-TOF-MS를 위해서, 겔 조각으로부터 10㎕ 절단 완충액을 이용하여 단백질을 추출하였다. 상청액은 ZipTipTM(Millipore, Bedford, USA)으로 농축시키고, 펩티드는 0.5㎕ 추출 완충액(0.1% TFA/CAN, 1:1)을 이용하여 MALDI 표적상에 용출시킨 다음, 0.5㎕ 매트릭스 용액(HCCA in ACN/0.1% TFA, 1:1)을 첨가하였다. SCOUT384 이온 소스가 갖추어진 REFLEX Ⅲ(Bruker Daltonik, Bremen, Germany)를 이용하여, MALDI-TOF-MS를 실시한다. 가속 볼트는 25kV로 설정하고, 투영 볼트는 28.7kV로 설정하였다. 질량 범위는 700Da 내지 4000Da으로 정한다. 데이터는 SUN Ultra상에서 XACQ 소프트웨어, version 4.0으로 인식하였다. 데이터 분석 과정은 XMASS 소프트웨어, version 4.02(Bruker Daltonik, Bremen, Germany)를 이용하여 실시하였다. 그 결과는 표 3과 4에 요약하였다.
실시예 6. 스타필로코커스 아우레우스( S. aureus )에서 면역원성이 높은 단백질의 특징
미리 선별된 혈청으로부터 IgG 및 IgA 조제물을 이용하여, 여러 가지 다른 선별 방법으로 확인된 항원은 다음과 같은 방법으로 추가 특징을 조사하였다;
1. 단백질을 정제하는데, 대장균 또는 Gram + 발현 시스템 또는 시험관내 해독 시스템에서 발현되는 재조합 단백질이 가장 적절하고, 인간 일련의 혈청으로 항원성을 평가하였다. 단백질은 생체 정보 분석을 기초하여 변형시키는데, 예를 들 면, 신호 펩티드를 나타내는 N-말단 서열을 제거하고; 세포 벽 고정을 하는 C-말단 하류도 제거하고, 정제를 용이하게 하기 위해 태그로 작용하는 여분의 아미노산을 첨가한다(Strep-tagⅡ, His-tag등). 상당수의 혈청을 ELISA에 이용하여, 일정한 단백질에 대해 특정 항체를 포함하는 인간 혈청 부분을 평가하였다(도 9, 실시예). 선택된 항원중 하나는 895aa의 긴 단백질로써, LPXTGV라고 칭하였는데(표 2, 4), 이렇게 명명한 이유는 Gram + 세포 벽 고정 서열 LPXTG을 포함하기 때문이다. 이와 같은 표시는 프로테오글리칸 세포벽에 대해 단백질을 포함하는 LPXTG 모티프를 공유적으로 연결시키는, 솔타제, 트란스-펩티다제에 대한 절단 부위로 작용한다(도 8). LPXTGV는 또한 전형적인 신호 펩티드를 갖고 있다(도 8). Strep-태그된 재조합 단백질로 이와 같은 단백질을 이용한 ELISA 데이터는 이와 같은 단백질은 다량의 혈청에서 매우 면역원성이 크다는 것을 설명한다(다른 재조합 단백질에 대해 높은 역가).(도 9). 중요한 것은 급성 스타필로코커스 아우레우스(S. aureus)에 감염된 환자는 건강한 사람보다 이들 항-LPXTGV 항체 더 많이 생산하고, 이는 단백질이 생체내 감염동안에 발현된다는 것을 나타낸다. 개별 항원성 단백질의 전체적인 ELISA 역가를 비교하였고, 대부분 개체에서 가장 높은 항체 수준을(가장 면역원성이 큰) 나타내는 것이 적당하다(생체내에서 대부분의 균주에 의해 단백질이 발현된다). 개별 환자에서 생산되는 스타필로코커스 아우레우스(S. aureus)에 대한 항체의 항원 특이성과 질(종류, 타입, 기능, 비기능)은 감염 부위, 수반되는 만성 질환(당뇨병), 장기적인 상태(가령, 맥관내 장치), 개체의 면역 반응 등에 따라 다양하기 때문에, 각 혈청에 속하는 의료기록을 이용하여, 상이한 환자군에서 감지되는 차이점에 주의한다. 또한, 각 환자 혈청은 혈청 샘플링 시기에 환자에서 분리한 병인 균주와 같이 수반된다.
2. 특이적인 항체는 추가 특징을 조사하기 위해 정제하였다. 재조합 단백질의 순도 및 완전성을 점검하였다(SDS-PAGE상에서 실버 착색과 비교하여 웨스턴 블랏 분석으로 N-말단 Strep-tag 감지). 항원은 태그를 통하여 고정시켜, 친화성 매트릭스를 만들고, 매우 반응성이 큰 혈청을 이용하여 특정 항체의 정제에 이용한다. 캡쳐 항원으로 예를 들면, Strep-태그된 LPXTGV를 이용하여, IgG 125㎎으로부터 20㎍의 항체를 정제하였다. ELISA 데이터를 기초하여, 항-LTA 및 항-펩티도글리칸활성(분절안된 IgG에 많은)을 가지고 있지 않은 순수한 정제물을 얻는다. 이들 항체를 이용하여, FACS 및 형광 현미경으로 세포 표면 위치를 확인한다(도 10).
3. 임상 분리물 내에서 유전자 발생
이상적인 백신 항원은 백신이 제공되는 표적 유기체의 모든 또는 대부분의 주요 균주에 존재하는 항원이 될 수 있을 것이다. 확인된 스타필로코커스 아우레우스(Staphylococcus aureus) 항원을 인코드하는 유전자가 스타필로코커스 아우레우스(S. aureus) 균주에 산재되어 발생하는지를 확인하기 위해, 관심의 대상이 되는 유전자에 특이적인 프라이머와 독립적인 스타필로코커스 아우레우스(S. aureus) 분리체상에서 PCR을 실행하였다. 스타필로코커스 아우레우스(S. aureus) 분리체는 다양한 스타필로코커스 아우레우스(S. aureus)에 감염된 환자로부터 수득하였다. 또한, 건강한 운반자 및 여러 가지 lab 균주에서 분리한 몇 가지 비강 분리체를 수득하고, 분석하였다. spa 및 coa 유전자(Goh et al. 1992, Frenay et al., 1994, vanden Bergh et al. 1999)의 제한효소 단편 길이 다양성(RFLP)에 따라 균주를 분류하였다. 이들 결과로부터 30가지 상이한 균주-24개 환자 분리체, 3개 비강 분리체, 3개 lab 균주-가 확인되었다. 선택된 항원의 유전자 분포를 확인하기 위해, 이들 30개 균주의 게놈 DNA를 선택된 에피토프에 인접한 유전자 특이적 프라이머로 PCR 시킨다(ORF1361: 서열번호 187 및 188; ORF2268: 서열 번호 193 및 194; ORF1951: 서열 번호 195 및 196; ORF1632: 서열 번호 181 및 182; ORF0766: 서열 번호 183 및 184; ORF0576: 서열 번호 185 및 186; ORF0222: 서열 번호 189 및 190; ORF0360: 서열 번호 191 및 192). PCR 생성물을 겔 전기영동을 이용하여 분석함으로써 정확하게 예상된 크기의 생성물을 확인할 수 있다. ORF 1361, 2268, 1951, 1632, 0766, 0222는 테스트한 균주 모두(100%)에 존재하였고, ORF0576는 97%에 존재하였다. 하지만, ORF0360은 균주의 71%에만 존재하였다. 따라서, ORF 1361, 2268, 1951, 1632 0766, 0576, 0222 각각은 각각 스타필로코커스 아우레우스(S. aureus) 분리물간에 요구되는 산재성을 가진다.
이들 항원(또는 이들 항원성 단편 특히 확인된 단편)은 스타필로코커스 아우레우스(S. aureus)에 대한 백신 프로젝트에 사용하기에 적합하다.
4. 선택된 항원의 ORF내에 무차별적인 HLA-클래스 II 보조 에피토프의 동정
사람의 혈청에 있는 항체에 의해 인지되는 것을 바탕으로 확인된 항원에 상응하는 ORF는 대부분이 선형 T-세포 에피토프를 포함하였다. 특히 본원 발명에서 놀라운 발견은 심지어 건강한 감염안된 그리고 콜로니가 형성안된 개체도 상당히 높은 역가를 나타내었는데(일부 항원의 경우에는 >100,000, 실시예 5 참고), 이는 1년 이상 안정하였다. 이는 CD4+ 보조-T-세포에 의해 대부분이 중개되는 T-세포 의존성 메모리가 존재한다는 것을 의미하는 것이다. 상응하는 HLA 클래스 II 보조-에피토프의 분자 정의는 면역학적 메모리를 유도할 수 있는 합성 항-스타필로코커스 백신을 고안하는데 유용하다. 이와 같은 시나리오에서, 스타필로코커스 항원에서 유도된 보조-에피토프는 “이들 항원 또는 이 항원의 단편에 대해 B-세포 반응에 ”동종과 같은 도움“을 제공한다. 또한, 이와 같은 보조-에피토프를 이용하면 탄수화물과 같은 T-독립 항원(공액체 백신)에 대한 메모리를 유도할 수 있다. 한편, 세포내에서 발생하는 스타필로코커스는 HLA 클래스 I 제한된 에피토프를 인지하는 CD8+ 세포독성 T-세포를 이용하면 제거할 수 있다.
다양한 각종 도메인에 있는 연산으로 T-세포 에피토프를 예상할 수 있다http://bimas.dcrt.nih.gov/molbio/hla bind/(Parker et al. 1994) http://134.2.96.221/scripts MHCServer.dll/home.htm(Rammensee at al. 1999), http://mypage.ihost.com/usinet.hammen76/(Sturniolo et al. 1999). 후자의 예상 연산으로 혼잡한 보조-에피토프 즉, 여러 가지 HLA 클래스 II 분자에 결합하는 펩티드와 같은 에피토프를 확인할 수 있는 가능성을 제공한다. 스타필로코커스 항원내에 매우 혼잡한 보조-에피토프를 확인하기 위해, 서열 번호 64(IsaA), 서열 번호 114(POV2), 서열 번호 89(ORF0222), 서열 번호 70(LPXTGIV), 서열 번호 56(LPXTGV), 서열 번호 142(LPXTGVI), 서열 번호 81(ORF3200), 서열 번호 74(ORF1951), 서열 번호 94(Empbp), 서열 번호 83(Autolysin), 서열 번호 58(ORF2498)에 상응하는 ORF를 TEPITOPE 패키 지(http://mypage.ihost.com/usinet.hamme76/(Sturniolo et al. 1999))를 이용하여 분석하였다. 25개의 흔한 DR-대립형질에 대해 분석하였고, 펩티드는 a)적어도 10/25개 대립형질에 대해 강한 결합물질(1%선) 또는 b) 적어도 17/25 대립형질에 대해 중간정도의 결합물질인 것으로 예상된다면 선별하였다.
다음은 한가지 또는 여러 가지 혼잡한 보조-에피토프를 포함하는 펩티드를 선별한 것이다;
서열 번호 56: pos. 6-40, 583-598, 620-646, 871-896
서열 번호 58: 선별 기준에 맞는 펩티드 없음.
서열 번호 64: 선별 기준에 맞는 펩티드 없음.
서열 번호 70: pos. 24-53
서열 번호 74: pos. 240-260
서열 번호 81: pos. 1660-1682, 1746-1790
서열 번호 83: pos. 1-29, 680-709, 878-902
서열 번호 89: pos. 96-136
서열 번호 94: pos. 1-29, 226-269, 275-326
서열 번호 114: pos. 23-47, 107-156
서열 번호 142: pos. 24-53
상응하는 펩티드 또는 이의 단편(예를 들면, 겹쳐지는 15-mer)을 합성하고, 시험관내에서 다양한 HLA 분자에 결합하는 능력에 대해 테스트하였다. 이들의 면역 원성은 펩티드(항원)-유도된 증식(BrdU 또는 3H-티미딘 결합) 또는 시험관내에서 T-세포의 사이토킨(ELIspot, intracellular cytokine staining) 분비를 평가함으로써 테스트할 수 있다(Mayer et al. 1996, Schmittel et al. 2000, Sester et al. 2000). 이에 대해, 최근에 감염되거나 콜로니 형성이 전혀 없었던 건강한 개체에 대해 상이한 스타필로코커스 감염 또는 콜로니가 형성된 환자군에서 선별된 혼잡한 펩티드 또는 이의 단편 또는 스타필로코커스 항원에 T 세포 반응성을 정량 및 정성 분석하는 것이 흥미롭다. 또한, 이와 같은 집단에서 관찰된 T-세포 반응의 양과 질, 항체 역가간에 상관관계를 예측할 수 있다. 또는, 예상된 펩티드의 면역원성은 HLA-유전자전이된 쥐에서 테스트하였다
스타필로코커스 항원내에 HLA 클래스 I 제한된 에피토프를 확인하는 데에도 비슷한 방법이 이용될 수 있다.
스타필로코커스 아우레우스( S. aureus )로부터 하나 또는 복수의 불규칙한 T-보조 에피토프를 나타내는 합성 펩티드
서열 번호 56(LPXTGV), 서열 번호 70(LPXTGIV), 서열 번호 74(ORF1hom1), 서열 번호 81(EM_BP), 서열 번호 83(Autolysin), 서열 번호 89(ORF1hom2), 서열 번호 94(EMPBP), 서열 번호 114(PVO2), 서열 번호 142(LPXTGVI)의 지정된 부분에 있는 부분적으로 겹쳐지는 펩티드를 합성하였다. 개별 펩티드 서열은 표 5에 제공하였다. 모든 펩티드는 Fmoc 화학을 이용하여 합성하고, HPLC 정제시키고, 질량 스펙트럼을 이용하여 분석하였다. 냉동건조된 펩티드를 DMSO에 용해시키고, -20℃에 5- 10mM 농도로 저장하였다.
시험관내에서 HLA 분자에 불규칙한 T-보조- 에피토프를 나타내는 합성 펩티드의 결합
항원을 제공하는 세포의 표면에 HLA 분자에 펩티드 결합은 T 세포 활성을 위한 필수조건이다. 결합은 HLA 클래스 II 분자의 재조합 가용성 부분을 이용하여, 시험관내에서 두 가지 독립적인 생화학적인 검사를 이용하여 평가하였다. 한 방법은 테스트되는 펩티드에 의해 라벨된 기준 펩티드가 농도 의존성 경쟁적인 치환을 측정하는 것이다. 두 번째 검사는 친화성이 높은 또는 중간정도의 리간드의 결합에서 SDS-안정한 복합체 형성에 기초한 것이다. 이 두 가지 검사에서 얻은 결과는 표 5에 제공하였다.
가용성 HLA 분자(DRA1*0101.DRB1*0101 및 DRA1*0101/DRB1*0401)는 SC-2 세포에서 발현되고, Aichinger et al., 1997에서 설명하는 것과 같이 정제하였다. 경쟁적인 검사(Hammer et al. 1995)를 하기 위해서는, HLA 분자를 50 내지 200ng/웰 농도로 제공하였다. DRB1*0101의 경우에는 비오틴화된 지시물질 펩티드 HA(PKYVKQNTLKLAT, Valli et al. 1993)를 0.008μM 농도로 이용하였다. DRB1*0401의 경우에, 비오틴화된 지시물질 펩티드 UD4(YPKFVKQNTLKAA, Valli et al. 1993)를 0.03 내지 0.06μM농도로 이용하였다. 테스트 펩티드는 0.02nM 내지 200μM 농도로 희석하여 이용하였다. 분자, 지시물질, 테스트 펩티드를 37℃, pH7에서 하룻밤동안 배양시켰다. 테스트 및 기준 펩티드(공지의 높은 친화성 결합물질 HA 및 UD4를 포지티브 기준으로 이용하였다)를 연속하여 희석시킴으로써 수득한 HLA:펩티드 복합 체를 항체 L243(이형이량체와 정확하게 연합되어 형성된 경우에만 적합한 에피토프를 인지하는 것으로 알려진)이 피복된 ELISA 플레이트에 포획시켰다. 결합된 비오틴은 기질로 NBT/BCIP 정제(Sigma)와 스트렙타비딘-알칼린 포스포타제 공액물(Dako)을 이용하여 표준 발색 감지를 이용하여 결합된 비오틴을 측정하고, Victor 판독기(Wallac)상에서 OD 값을 판독한다.
IFNg
ELIsot
분석으로 평가된 혼잡한 T 보조에 대한 T 세포 반응
항원 자극시에 T 세포는 증식을 시작하고, 인터페론 감마(IFNg)와 같은 사이포킨을 분비하기 시작한다. 스타필로코커스 아우레우스(S. aureus)내에 에피토프를 특이적으로 인지하는 인간 T 세포는 IFNg-ELIspot(Schmittel et al. 2000)에 의해 감지된다. 강력한 항-스타필로코커스 아우레우스 IgG 반응을 가지는 건강한 개체로부터 PBMC는 Ficoll 밀도차 원심분리를 이용하여 정맥혈로부터 50-200㎖를 분리하였고, 이는 냉동 및 해동 후에 이용하였다. 세포는 96-웰 플레이트 상에 200,000/웰 농도로 접종한다. 펩티드는 개별 항원에 상응하는 혼합물로 첨가되는데, 각 경우에 농도는 10㎍/㎖로 한다. 콘카나발린 A(Amersham), PPD(튜베르큘린 정제된 단백질 유도체, Statens Serum Institute)는 검사의 포지티브 기준으로 사용하고, 펩티드가 전혀 존재하지 않는 검사 배지는 네거티브 기준으로 이용한다. 항-인간 IFNg 단클론항체 B140(Bender Med Systems)으로 피복시킨 Multi Screen 96웰 여과 플레이트(Millipore)로 하룻밤동안 배양시킨 후에, ELIspot는 비오틴화된 항-인간 IFNg 단클론 항체 B308-BT2(Bender Med Systm), 스트렙타비딘-알칼리 포스포타제(DAKO), BCIP/NBT 알칼리 포스포타제 기질(SIGMA)을 이용하여 발생시킨다. 플레 이트 자동 판독기(Bioreader 2000, BIO-SYS)를 이용하여 반점을 헤아린다. 검사 배지(네거티브 기준, 일반적으로 100,000 세포당 10개미만의 반점)만으로 자극을 한 세포와 웰에 있는 카운트된 반점은 배경으로 간주하고, 펩티드와 웰에서 카운트된 반점을 뺀다.
[표 5]
스타필로코커스 아우레우스(S. aureus) 항원에 포함된 불규칙한 T 보조 에피토프
1) 가용성 DRA1*0101/DRB1*0401 분자에 결합은 경쟁 검사로 결정한다(+, ++: 결합; -: 200μM 테스트 펩티드까지 경쟁 없음: nd: 실시하지 않음)
2) 강력한 항-스타필로코커스 아우레우스 IgG 반응을 보이는 5명의 건강한 개체에서 얻은 결과.
5. 항원을 생쥐에 투여하고-이들 단백질에 대한 항체를 측정할 수 있다.
6. 동물 모델에서 예방접종을 통하여 항원에 의해 유도된 항체의 보호 능력을 평가하였다.
5와 6은 당 기술 분야에 지식을 가진 자가 흔히 이용할 수 있는 방법이다.
실시예
7: 응용
A) 효과적인 백신은 일반적으로 선택적 외과술을 받는 환자, 특히 맥관내 장치를 수용해야할 환자에게 상당한 잠재성을 제공한다. 면역 반응이 감소된 만성질환으로 고통을 받는 환자 또는 지속적인 보행 투석을 받는 환자는 본원 발명에 따른 면역원성 혈청-반응성 항원으로 스타필로코커스 아우레우스(S. aureus) 백신으로 이익을 얻을 수 있다. 관련 항원의 동정은 효과적인 수동 면역화(인화 단클론 항체 치료법)를 생성하는데 도움이 될 것이고, 이는 위험한 부작용이 수반되는 인간 면역글로불린 투여에 대체 요법이 될 수 있다. 따라서, 효과적인 백신은 일반적으로 선택적 외과술을 받는 환자, 특히 맥관내 장치를 수용해야할 환자에게 상당한 잠재성을 제공한다.
스타필로코커스 아우레우스(S. aureus)는 많은 상이한 질환을 유발시킬 수 있다.
1. 폐혈증, 박테리아혈증
2. 혈액투석된 환자 - 박테리아 혈증, 폐혈증
3. 복막 투석 혼자 - 복막염
4. 맥관내 장치를 한 환자(심장 수술) 심장내막염, 박테리아혈증, 폐혈증
5. 보철 장치를 한 정형외과 환자 -폐혈증 관절염
6. 일반적인 예방 백신
B) 수동성 및 능동성 백신, 두 가지 경우 모두 특별한 주의를 요하는데, T 세포의 경우에는 후자에 주의를 요한다; 면역접종 과정동안에 강력한 T 보조 반응을 유도하여, 효과적인 체액 반응 및 면역학적 메모리를 얻을 수 있다. 지금까지, T-세포가 스타필로코커스 아우레우스(S. aureus) 감염을 제거하는데 중요한 역할을 할 것이라고 보여주는 직접적인 증거는 없었고, 적절하게 제기된 적도 없다. 단백질성 항원에 대한 효과적인 체액 반응은 T 보조가 연관이 되었을 것이고, 메모리를 개발하는 것이 필수적일 것이다. 고유 CD4+ 세포는 Th1 또는 Th2 세포로 분화할 수 있다. 고유 면역학적 반응(사이토킨)이 이와 같은 결정에 영향을 줄 수 있기 때문에, T-세포와의 연관성은 자연적인 감염 과정동안에 면역 반응을 손상시키는 성분을 포함하지 않은 백신 소단위로 건강한 개체를 면역화시키는 것에 관련된 급성, 연속 감염과는 다를 것이다. Th1 또는 Th2 반응을 유도한 결과는 상당한 것이다. Th1 세포는 세포-주액된 면역원성을 유도하고, Th2 세포는 체액 면역원성을 제공한다.
C) 예방과 치료 백신
예방: 감염 전에 위험이 높은 군의 사람에게 활성이 있는 백신 주사/수동적 인 면역화
치료: 이미 병든 환자 군에게 수동적인 백신제공
비강을 통한 운반을 없애기 위한 활성 예방접종
*구체적인 응용 사례
MRSA
보균의 제거 및 의료 인원의
상재화
예방
외래환자의 콧구멍에 스타필로코커스 아우레우스(S. aureus)의 운반 비율은 10 내지 40%이다. 입원 환자나 구성원들은 더 높은 보균율을 가진다. 혈액 투석을 하는 환자, 당뇨, 약물 중독, 다양한 상태의 피부병이 있는 환자에는 그 비율이 특히 높다. MRSA 감염 위험이 가장 높은 혼자는 3차-치료 병원에 있는 환자, 특히, 노인, 중환자실에 있는 면역약화된 혼자, 화상 환자, 외과적인 상처가 있는 환자 및 정맥내 카테터를 가진 환자 등이다.
ELISA 데이터는 스타필로코커스 아우레우스(S. aureus)에 대한 뚜렷한 IgA 반응이 존재한다는 것을 강력하게 제시하는데, 이는 기존 문헌에서는 분명하지 않거나 공지되지 않은 사실이다. 주요 점막 면역 반응이 중화 활성을 갖는 IgA의 생산이기 때문에, 고순도 IgA 조제물로 동정된 스타필로코커스 에피토프 및 항원이 효과적인 점막 백신을 유도한다는 것은 명백하다.
● 명백한 징후: 수술을 실시하는 부서(특히, 정형외과, 외상, gen. 외과술)의 모든 사람에게 위험.
● 예방접종에 익숙한 집단(의사 및 간호사)
● 스타필로코커스 아우레우스(S. aureus)의 균주를 비강내 운반자로 확인된 건강센터 직원은 세균이 제거될 때까지 뮤피로신 및 리팜피신 치료를 받는다. 일부의 경우에는 효과가 없고 시간이 소요된다.
● 이용할 수 있는 동물 모델: 비강 운반용 생쥐 모델이 있다.
[표 1]
감염안된 개체로부터 혈청의 다중 스타필로코커스 단백질에 대한 ELISA 역가
표 1. 감염안된 개체로부터 혈청의 다중 스타필로코커스 단백질에 대한 ELISA 역가
항-스타필로코커스 항체 수준을 표준 ELISA로 개별적으로 측정하는데, 이때, BHI 배지(BHI), 리포테이코산(LTA), 펩티도글리칸(PG), 13개의 재조합 단백질을 제시하는 세포 표면 및 클럼핑 인자 A, B(Clfa, ClfB)와 같은 분비된 단백질, 피브로넥틴 결합 단백질(FnBPA), SD-반복 단백질(SdrC, sdrE), MHC 클래스 II 유사성 단백질(map-w), 엘라스틴-결합 단백질(EBP), 에노라제(세포 표면에 위치하고, 면역원성으로 알려짐), 철 운반 리포프로테인(LP3019, LP342), 솔타제(srtA), 코아굴라제(coa), 세포외 피브리노겐-결합 단백질(fib)에서 생장시킨 스타필로코커스 아우레우스(S. aureus)에서 준비된 전체 용해질을 이용한다. FnBPA으로부터 5개의 면역우성 D 반복 도메인중 2개를 나타내는 두 개의 짧은 합성 펩티드(D1+D3)가 항원으로 포함된다. 개별 혈청은 IgG 역가에 기초하여 순서를 정하고, 1-9까지 순서를 부여한다. 숫자 1은 가장 높은 역가에 부여하고, 숫자 8 또는 9는 일정한 항원에 대해 테스트된 모든 혈청에서 8번째나 9번째가 되는 혈청에 부여된다. 이는 혈청의 상위 20%(8-9/40) 분석 결과이다. 항-스타필로코커스 항체에 대해 가장 높은 반응성이 있다는 것을 의미하는 다섯 개 “베스트 혈청”은 숫자 1-8을 기초하여 선별한다. ***의미는 특정 항원에 대한 항체 반응성이 예외적으로 높다는 것을 의미한다(en 번째 반응성 혈청에 대한 >2x ELISA 유닛).
표 2a: 세균성 표면 및 리보솜 전시에 의해 확인된 면역원성 단백질: 스타필로코커스 아우레우스(S. aureus)
세균성 표면 전시: 환자 혈청 1(655)의 fhuA 내에 A, LSA250/1 라이브러리; B, lamB 내에 LSA50/6 라이브러리, 환자 혈청 1(484); C, fhuA 내에 LSA250/1 라이브러리, IC 혈청 1(571); E, lamB 내에 LSA50/6 라이브러리, IC 혈청 2(454); F, lamB 내에 LSA50/6 라이브러리, 환자 혈청 P1(1105); G, lamB 내에 LSA50/6 라이브러리, IC 혈청 1(471); H, fhuA 내에 LSA250/1 라이브러리, 환자 혈청 1(IgA, 708); 리보솜 전시: D, LSA250/1 라이브러리, IC 혈청(1686). *는 조사된 33개 중에서 18회 확인됨; 따라서 스크린 C에서 제거됨. **, 5개 이상 아미노산보다 더 긴 항원 서열 예측은 프로그램 ANTIGENIC(Kolaskar and Tongaonkar, 1990)을 이용하여 실행하였고; #, ORF에 2개씩 존재하는 동일한 서열; ##, 데이터베이스에 없는 서열(TIGR에 의해 서열화되지 않음).
[표 2a]
표 2b: 세균성 표면 및 리보솜 전시에 의해 확인된 추가 면역원성 단백질: 스타필로코커스 아우레우스(S. aureus)
세균성 표면 전시: 환자 혈청 1(655)의 fhuA 내에 A, LSA250/1 라이브러리; B, lamB 내에 LSA50/6 라이브러리, 환자 혈청 1(484); C, fhuA 내에 LSA250/1 라이브러리, IC 혈청 1(571); E, lamB 내에 LSA50/6 라이브러리, IC 혈청 2(454); F, lamB 내에 LSA50/6 라이브러리, 환자 혈청 P1(1105); G, lamB 내에 LSA50/6 라이브러리, IC 혈청 1(471); H, fhuA 내에 LSA250/1 라이브러리, 환자 혈청 1(IgA, 708); 리보솜 전시: D, LSA250/1 라이브러리, IC 혈청(1686). **, 5개 이상 아미노산보다 더 긴 항원 서열 예측은 프로그램 ANTIGENIC(Kolaskar and Tongaonkar, 1990)을 이용하여 실행하였다. ORF: 개방 해독틀; CRF, 상보서열의 해독틀; ARF, 또 다른 방식으로 판독되는 프레임.
[표 2b]
표 2c: 세균성 표면 및 리보솜 전시에 의해 확인된 면역원성 단백질: 스타필로코커스 에피데르미디스(S. epidermidis)
세균성 표면 전시: 환자 혈청 1(957)의 fhuA 내에 A, LSE150 라이브러리; B, lamB 내에 LSE70 라이브러리, 환자 혈청 2(1420); C, lamB 내에 LSE70 라이브러리, 환자 혈청 1(551); 리보솜 전시: D, pMAL4.31과 P2(1235)에 LSE150. **, 5개 이상 아미노산보다 더 긴 항원 서열 예측은 프로그램 ANTIGENIC(Kolaskar and Tongaonkar, 1990)을 이용하여 실행하였다. ORF: 개방 해독틀; CRF, 상보서열의 해 독틀; ARF, 또 다른 방식으로 판독되는 프레임; ORF: 개방 해독틀; CRF 상보 가닥상의 해독틀.
[표 2c]
표 2d: 세균성 표면 및 리보솜 전시에 의해 확인된 면역원성 단백질: 스타필로코커스 아우레우스(S. aureus)(새로운 주석)
세균성 표면 전시: 환자 혈청 1(655)의 fhuA 내에 A, LSA250/1 라이브러리; B, lamB 내에 LSA50/6 라이브러리, 환자 혈청 1(484); C, fhuA 내에 LSA250/1 라이브러리, IC 혈청 1(571); E, lamB 내에 LSA50/6 라이브러리, IC 혈청 2(454); F, lamB 내에 LSA50/6 라이브러리, 환자 혈청 P1(1105); G, lamB 내에 LSA50/6 라이브러리, IC 혈청 1(471); 리보솜 전시: D, LSA250/1 라이브러리, IC 혈청(1686). **, 5개 이상 아미노산보다 더 긴 항원 서열 예측은 프로그램 ANTIGENIC(Kolaskar and Tongaonkar, 1990)을 이용하여 실행하였다. #, ORF에서 2개씩 존재하는 동일한 서열.
[표 2d]
[표 3a]
인간 혈청을 이용한 스타필로코커스 아우레우스(S. aureus) 표면 단백질의 혈청학적 프로테옴 분석
a) 스타필로코커스 아우레우스(S. aureus)/agr “스트레스 조건”
[표 3b]
스타필로코커스 아우레우스(S. aureus)/COL “표준 조건”
[표 3c]
스타필로코커스 아우레우스(S. aureus)/COL “스트레스 조건”
[표 4]
MALDI-TOF-MS 서열화에 의해 확인된 스타필로코커스 아우레우스(S. aureus) 항원(굵게 표시된 ORF는 세균성 표면 전시에 의해 확인되었다). 인간 혈청을 이용한 혈청학적 프로테옴 분석에 의해 확인된 선별된 항원에서 항원성 부분 예측.
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도 1은 ELISA로 측정된 항-스타필로코커스(Staphylococcus) 항체 역가에 기초한 혈청의 사전-선별을 도시한다.
도 2는 pMAL4.1에서 LSA50/6 라이브러리 DNA 단편의 크기 분포를 보여준다.
도 3은 비오틴화된 사람혈청으로 MACS 선별을 도시한다. pMAL9.1에서 LSA50/6 라이브러리는 1차 선별(A)에서 10 ㎍ 비오틴화된 인간 혈청으로, 2차 선별(B)에서 1 ㎍ 비오틴화된 인간 혈청으로 선별한다. P.혈청, 환자 혈청; B.혈청, 유아 혈청. 2nd와 3rd 용리후 선별된 세포 수를 각 선별 라운드에 도시한다.
도 4는 1:5000으로 희석된 환자 혈청의 웨스턴 블랏 분석에서 박테리아 표면 전시로 분리된 특정 클론과의 혈청 반응성을 도시한다.
도 5는 리보솜 전시로 동정된 에피토프를 갖는 환자와 건강한 개체로부터 얻은 혈청을 이용한 펩티드 ELISA를 도시한다.
도 6은 인간 혈청으로 검출된 스타필로코커스 아우레우스(S. aureus) 표면 단백질의 대표적인 2D 면역블랏을 도시한다. BHI에서 배양된 스타필로코커스 아우레우스(S. aureus)/COL로부터 얻은 800 ㎍ 단백질은 IEF(pI 4-7)와 SDS-PAGE(9-16%)로 용해시키고, 이후 PDF 막으로 옮겼다. 차단후, 상기 막은 혈청 IC35(1:20,000)와 함께 배양하였다. 혈청 IgG의 결합은 항-인간 IgG/HRPO 공액체 및 ECL 발생으로 시각화시켰다.
도 7은 Coomassie Blue로 염색된 스타필로코커스 아우레우스(S. aureus) 표 면 단백질의 대표적인 2D 겔을 도시한다. 스타필로코커스 아우레우스(S. aureus)/COL로부터 얻은 1 ㎎ 단백질은 IEF(pI 4-7)와 SDS-PAGE(9-16%)로 용해시켰다. 혈청학적 프로테옴 분석이후 서열분석을 위하여 선택된 반점(spot)은 표시한다.
도 8A와 8B는 LPXTG 세포벽 단백질의 구조를 도시한다.
도 9는 본원 발명의 박테리아 표면 전시와 프로테오믹스 방식으로 발견된 스타필로코커스 아우레우스(S. aureus)의 신규한 항원이며 가능 표면 부착요소인 LPXTGV에 감염되지 않은 군(N,C)과 감염된 환자(P)에서 IgG 반응을 도시한다.
도 10은 정제된 항-LPXTGV IgG로 스타필로코커스 아우레우스(S. aureus)의 표면 염색을 도시한다.
도 11은 스타필로코커스 아우레우스(S. aureus) 표면 단백질이 Coomassie Blue에 의해 염색되는 2D 겔을 보여준다(좌측). 초기 로그상까지 배양된 스타필로코커스 아우레우스(S. aureus)/agr의 1 ㎎ 단백질은 IEF(pI 6-11)와 SDS-PAGE(9-16%)에 용해시켰다. 혈청학적 프로테옴 분석이후 서열분석을 위하여 선택된 반점은 표시한다. 상응하는 2D-면역블랏(우측). 동일 조제물의 800 ㎍ 단백질은 2DE로 동시에 용해시키고, 이후 PVDF 막으로 옮겼다. 차단후, 상기 막은 P-풀(1:10,000)과 함께 배양하였다. 혈청 IgG의 결합은 항-인간 IgG/HRPO 공액체 및 ECL 발달로 시각화시켰다.
SEQUENCE LISTING
Intercell Biomedizinische Forschungs- und Entwicklungs AG
Cistem Biotechnologies GmbH
R 39035
Priority: Austrian Patent Application No. A 130/2001 of 26.01.2001
Seq.ID Nos. 1-598
Organisms: S.aureus; S.epidermidis
1.
atgaacaaacagcaaaaagaatttaaatcattttattcaattagaaagtcatcactaggc
gttgcatctgtagcaattagtacacttttattattaatgtcaaatggcgaagcacaagca
gcagctgaagaaacaggtggtacaaatacagaagcacaaccaaaaactgaagcagttgca
agtccaacaacaacatctgaaaaagctccagaaactaaaccagtagctaatgctgtctca
gtatctaataaagaagttgaggcccctacttctgaaacaaaagaagctaaagaagttaaa
gaagttaaagcccctaaggaaacaaaagaagttaaaccagcagcaaaagccactaacaat
acatatcctattttgaatcaggaacttagagaagcgattaaaaaccctgccataaaagac
aaagatcatagcgcaccaaactctcgtccaattgattttgaaatgaaaaagaaagatgga
actcaacagttttatcattatgcaagttctgttaaacctgctagagttattttcactgat
tcaaaaccagaaattgaattaggattacaatcaggtcaattttggagaaaatttgaagtt
tatgaaggtgacaaaaagttgccaattaaattagtatcatacgatactgttaaagattat
gcttacattcgcttctctgtatcaaacggaacaaaagctgttaaaattgttagttcaaca
cacttcaataacaaagaagaaaaatacgattacacattaatggaattcgcacaaccaatt
tataacagtgcagataaattcaaaactgaagaagattataaagctgaaaaattattagcg
ccatataaaaaagcgaaaacactagaaagacaagtttatgaattaaataaaattcaagat
aaacttcctgaaaaattaaaggctgagtacaagaagaaattagaggatacaaagaaagct
ttagatgagcaagtgaaatcagctattactgaattccaaaatgtacaaccaacaaatgaa
aaaatgactgatttacaagatacaaaatatgttgtttatgaaagtgttgagaataacgaa
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tatatggtcatggaaactactaatgacgattactggaaagatttcatggttgaaggtcaa
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gatggacaataccatgtcagaatcgttgataaagaagcatttacaaaagccaataccgat
aaatctaacaaaaaagaacaacaagataactcagctaagaaggaagctactccagctacg
cctagcaaaccaacaccatcacctgttgaaaaagaatcacaaaaacaagacagccaaaaa
gatgacaataaacaattaccaagtgttgaaaaagaaaatgacgcatctagtgagtcaggt
aaaggcgtaacgcttgctacaaaaccaactaaaggtgaagtagaatcaagtagtacaact
ccaactaaggtagtatctacgactcaaaatgttgcaaaaccaacaactggttcatcaaaa
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ttacaaaaagcaaacattaaacacacaaatgatggacacactcaaagccaaaacaataaa
aatacacaagaaaataaagcaaaatcattaccacaaactggtgaagaatcaaataaagat
atgacattaccattaatggcattattagctttaagtagcatcgttgcattcgtattacct
agaaaacgtaaaaactaa
2.
atgagaaatatagagaatctaaatcccggagattcagttgatcactttttcttagtgcat
aaagctacacagggtgtaacagcacaaggtaaagattatatgacattacatttgcaagat
aaaagtggtgaaattgaagcgaaattttggacggctacaaaaaatgatatggcaacaatc
aagcctgaagaaattgtacatgttaaaggtgacatcataaactatcgcggaaataaacag
atgaaagtcaaccaaattagactagcgacaactgaagatcaattaaaaacagaacaattt
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cgattttacacatatccagctgctagttctcatcatcataactttgcgagtggcttaagc
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aacaaaagtttgttatatagtggtattattttgcatgatattggtaaagttagagaattg
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ttgttaagacatatgattttatctcatcatggtaagttagagtatggttctccaaaactg
ccatacttaaaagaagcagaaattttatgctatatcgataatatcgatgctagaatgaat
atgtttgaaaaggcatataaaaaaactgacaagggtcagtttacagataaaatatttggt
cttgaaaatcgtagattctacaatcctgaatcactcgat
3.
atgaacaaacatcacccaaaattaaggtctttctattctattagaaaatcaactctaggc
gttgcatcggtcattgtcagtacactatttttaattacttctcaacatcaagcacaagca
gcagaaaatacaaatacttcagataaaatctcggaaaatcaaaataataatgcaactaca
actcagccacctaaggatacaaatcaaacacaacctgctacgcaaccagcaaacactgcg
aaaaactatcctgcagcggatgaatcacttaaagatgcaattaaagatcctgcattagaa
aataaagaacatgatataggtccaagagaacaagtcaatttccagttattagataaaaac
aatgaaacgcagtactatcactttttcagcatcaaagatccagcagatgtgtattacact
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gtctatgaaaacaatcaaaaattgccagtgagacttgtatcatatagtcctgtaccagaa
gaccatgcctatattcgattcccagtttcagatggcacacaagaattgaaaattgtttct
tcgactcaaattgatgatggagaagaaacaaattatgattatactaaattagtatttgct
aaacctatttataacgatccttcacttgtaaaatcagatacaaatgatgcagtagtaacg
aatgatcaatcaagttcagtcgcaagtaatcaaacaaacacgaatacatctaatcaaaat
acatcaacgatcaacaatgctaataatcaaccgcaggcaacgaccaatatgagtcaacct
gcacaaccaaaatcgtcaacgaatgcagatcaagcgtcaagccaaccagctcatgaaaca
aattctaatggtaatactaacgataaaacgaatgagtcaagtaatcagtcggatgttaat
caacagtatccaccagcagatgaatcactacaagatgcaattaaaaacccggctatcatc
gataaagaacatacagctgataattggcgaccaattgattttcaaatgaaaaatgataaa
ggtgaaagacagttctatcattatgctagtactgttgaaccagcaactgtcatttttaca
aaaacaggaccaataattgaattaggtttaaagacagcttcaacatggaagaaatttgaa
gtttatgaaggtgacaaaaagttaccagtcgaattagtatcatatgattctgataaagat
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attgaatatggtgagaacatccatgaagactatgattatacgctaatggtctttgcacag
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ttagctccgtatcacaaagctaaaacgttagaaagacaagtttatgaattagaaaaatta
caagagaaattgccagaaaaatataaggcggaatataaaaagaaattagatcaaactaga
gtagagttagctgatcaagttaaatcagcagtgacggaatttgaaaatgttacacctaca
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caaaaatatgtagtgatgaaaacaaaggatgacagttactggaaagatttaattgtagaa
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gatacatcacaaaataacacgagtgaaccgctaaatgtacaaacaggacaagaaggtaag
gttgctgatacagatgtagctgaaaatagcagcactgcaacaaatcctaaagatgcgtct
gataaagcagatgtgatagaaccagagtctgacgtggttaaagatgctgataataatatt
gataaagatgtgcaacatgatgttgatcatttatccgatatgtcggataataatcacttc
gataaatatgatttaaaagaaatggatactcaaattgccaaagatactgatagaaatgtg
gataaagatgccgataatagcgttggtatgtcatctaatgtcgatactgataaagactct
aataaaaataaagacaaagtcatacagctgaatcatattgccgataaaaataatcatact
ggaaaagcagcaaagcttgacgtagtgaaacaaaattataataatacagacaaagttact
gacaaaaaaacaactgaacatctgccgagtgatattcataaaactgtagataaaacagtg
aaaacaaaagaaaaagccggcacaccatcgaaagaaaacaaacttagtcaatctaaaatg
ctaccaaaaactggagaaacaacttcaagccaatcatggtggggcttatatgcgttatta
ggtatgttagctttattcattcctaaattcagaaaagaatctaaa
4.
Atgtcagattttaatcatacagatcattctacaacaaaccatagccaaacacctagatac
Agaagacctaaatttccatggtttaaaacagtcatcgttgcattgattgctggaattatt
Ggtgcacttctagtacttggtataggcaaagtattaaatagtacaattttaaataaagat
Ggttcaactgttcagacaacaaataataaaggtggcaatcaattagacggtcaaagcaag
Aaattcggtaccgttcatgaaatgataaaatctgtctcccctacaattgttggagttatt
Aacatgcaaaaagcatcaagtgtagacgacttattaaaaggcaaatcatctaaaccatct
Gaagctggagtaggttcaggtgttatctatcaaataaacaacaattcagcttatatcgtt
Acaaacaatcatgttattgatggcgcaaatgaaattagagtccaattacataataaaaaa
Caagttaaagcgaaattagttggtaaagatgcagtaactgatattgctgtacttaaaatt
Gaaaatacaaaaggtattaaagcgattcaatttgccaactcttcaaaagtacaaactggc
Gatagcgtattcgcaatgggtaacccattaggattacaatttgctaactctgtaacatct
Ggtatcatttcagcaagcgaacgtacgattgacgctgagacaactggtggcaatacaaaa
Gttagcgttcttcaaacagatgctgctattaacccaggtaactcaggtggcgcattagta
Gatattaatggtaatttagttggtattaactcaatgaaaattgctgcgacacaagttgaa
Ggtatcgggtttgctattccaagtaatgaagttaaagtaacaattgaacaacttgtaaaa
Catggtaaaattgaccgcccttcgattggtattggtttaattaatttgaaagatattcct
Gaagaagagcgcgagcaacttcatactgatagagaagacggtatttatgtcgccaaagct
Gatagtgatattgatcttaaaaaaggtgatattattacagaaattgatggcaagaaaatt
Aaagatgatgttgatttaagaagctatttatatgaaaataaaaaacctggtgaatcagtc
Actgttaccgttatccgtgatggtaaaacaaaagaagttaaagtgaaattaaaacaacaa
Aaagaacaaccaaaacgtcaaagccgatcagaacgtcaatcacctggccaaggcgataga
gatttctttaga
5.
ttgatgattaatgaaagagaagtgtttattttgatatatctagataatgcggcamcgacg
aaagcatttgaagaagtgttagatacttatttaaaagtaaatcaatcaatgtattataat
ccgaatagtccgcataaagctggtttgcaggcaaatcaattactacaacaagcaaaaacc
caaattaatgcaatgattaattcaaaaacaaattatgatgttgtattcactagtggtgca
actgaatccaataatcttgctttaaaaggtattgcctatcgtaaatttgatacagcgaag
gaaataattacatccgtgttagagcatccgtccgtattagaggttgtaagatatttggaa
gcacacgaaggatttaaagttaaatatgttgatgtaaagaaagatggcagtattaactta
gaacacttcaaagaattaatgtcagacaaagtcggtttagtaacatgtatgtatgtaaat
aatgtaactggacaaatacagcctattccacaaatggctaaagttataaaaaattatcct
aaggcacattttcatgtagatgcggttcaagcattcggcaaaatttcaatggatctcaat
aacatagatagtattagtttaagtggacacaagtttaatggtttaaaaggacaaggcgtc
ttacttgtaaatcacattcaaaatgttgaaccaactgtccatggtggtggtcaagaatat
ggcgttagaagtggaacagttaatttgccaaatgatattgcaatggttaaagcgatgaag
atagctaatgaaaactttgaagcattgaatgcatttgttactgagttaaataatgacgtc
cgtcaatttttaaataaatatcatggagtttatattaattcttcaacttcaggttcacca
ttcgttttaaatattagttttcctggcgtaaaaggtgaagtattagttaatgctttttca
aaatatgacattatgatatctacgacaagtgcttgttcatctaaacgtaataaattaaat
gaagtattggctgcaatgggattatcagacaaatctattgaaggtagtataagattatca
tttggggctactacaactaaagaagatatagcgaggtttaaagaaatatttatcatcatt
tatgaggaaattaaggagttgctaaaa
6.
gtgaaccaacaacaggagaaaacaacaacaacgccaacaacaattaatccattaacggga
gaaaaagtaggcgaaggtgaaccaacaacagaagtaacaaaagaaccagtagatgaaatc
acacaattcggtggagaagaagtaccacaaggtcataaagatgagttcgatccaaactta
ccaattgacggtacagaagaagtaccaggtaaaccaggcatcaagaatcctgaaacaggt
gaagtagtaacacctccggttgacgatgtcacaaaacatggtccaaaagcaggcgaacca
gaggttactaaagaagaaataccattcgagaaaaaacgtgagttcaatccagacttaaaa
ccaggtgaagagaaagtaacgcaagaaggacaaactggagagaaaacaacaacaacgcca
acaacaattaatccattaacgggagaaaaagtaggcgaaggtgaaccaacaacagaagta
acaaaagaaccagtagatgaaatcacacaattcggtggagaagaagtaccacaaggtcat
aaagatgagttcgatccaaacttaccaattgacggtacagaagaagtaccaggtaaacca
ggcatcaagaatcctgaaacaggtgaagtagtaacaccaccagtagacgatgtcacaaaa
catggtccaaaagcaggcgaaccagaggttactaaagaagaaattccatatgaaactaaa
cgcgtattagatccaacaatggaaccaggtagtcctgataaagtagctcaaaaaggtgaa
aatggtgaaaaaacaacaacaacaccaactacaattaatccattaacgggagaaaaagta
ggcgaaggcgaaccaacaacggaagtaacgaaagaaccaatagacgaaattgttaactat
gcacctgaaattattcctcatggtacacgtgaagaaattgatccaaacttaccagaaggt
gaaactaaagttatcccaggtaaagatggcttgaaagatcctgaaactggagaaatcatt
gaagaaccacaagatgaagtaatcatccatggtgctaaagatgattcagatgcggacagc
gattcagacgcagatagcgattctgatgcagacagcgactcagacgcagatagcgactct
gatgcggacagcgattcagacagcgatagcgattcagattcagatagcgactctgatgcg
gacagcgattcagacgcagatagcgattcagattcagatagtgactctgatgcggacagc
gactcagacgcagatagcgactctgatgcggacagcgactcagacgcagatagcgattct
gattcagacagcgactcagacgcagatagcgactcagattcagacagcgattcagacgca
gatagcgactcagacgcagatagcgattcagacgcagatagcgactcagacgcagatagc
gattcagattcagatagcgactctgatgcggacagcgatagcgattcagattcagacagc
gactcagacgcagatagcgattcagacagcgattcagacgcagatagcgactctgatgcg
gacagcgactcagacgcagatagcgactcagacgcagatagcgattcagattcagacagc
gactcagattcagacagcgatagcgattcagattcagacagagactcagacgcagatagc
gactcagacgcagatagcgactcagattcagacagcgattcagacgcagatagcgattca
gattcagatagtgactctgatgcggacagcgattcagacgcagatagcgactcagattca
gacgcagatagcgattctgattcagacagcgactcagacgcagatagcgactctgatgcg
gacagcgactcagacgcagatagcgattctgatgcagacagcgactcagacagcgatagc
gattctgattcagacagcgattcagacgcagatagcgactctgatgcggacagcgattca
gacgcagatagagatcataatgacaaaacagataaaccaaataataaagagttaccagat
actggtaatgatgctcaaaataatggcacattatttggttcactattcgctgcgcttgga
ggattattcttagttggcagacgtcgtaaaaacaaaaataatgaagaaaaa
7.
gtgaagtcattgaagacggtgattgggatgaataataaggagcatattaaatctgtcatt
ttagcactactcgtcttgatgagtgtcgtattgacatatatggtatggaacttttctcct
gatattgcaaatgtcgacaatacagatagtaagaagagtgaaacgaaacctttaacgaca
cctatgacagccaaaatggatacaactattacgccatttcagattattcattcgaaaaat
gatcatccagaaggaacgattgcgacggtatctaatgtgaataaactgacgaaacctttg
aaaaataaagaagtgaagtccgtggaacatgttcgtcgtgatcataacttgatgattcct
gatttgaacagtgattttatattattcgattttacgtatgatttaccgttatcaacatat
cttggtcaagtactgaacatgaatgcgaaagtaccaaatcatttcaatttcaatcgtttg
gtcatagatcatgatgctgatgataatatcgtgctttatgctataagcaaagatcgccac
gattacgtaaaattaacaactacaacgaaaaatgatcattttttagatgcattagcagca
gtgaaaaaagatatgcaaccatacacagatatcatcacaaacaaagatacaattgatcgt
acgacgcatgtttttgcaccaagtaaacctgaaaagttaaaaacatatcgcatggtattt
aacacgattagtgttgagaaaatgaatgctatactatttgacgattcaaccatcgttcgt
agttcaaagagtggtgttacaacctacaacaataatacaggtgtcgcaaactataacgat
aaaaatgaaaaatatcattataaaaacctgtccgaagatgaagcgagttccagcaaaatg
gaagaaacgattccaggaacctttgattttattaatggtcatggtggtttcttaaacgaa
gactttagattgtttagtacgaataatcagtcaggcgagttaacatatcaacgtttcctt
aatggttatccaacgtttaataaagaaggttctaatcaaattcaagtcacttggggtgaa
aaaggcgtctttgactatcgtcgttcgttattacgcaccgacgttgttttaaatagtgag
gataataaatcgttgccgaaattagagtctgtacgttcaagcttagcgaacaatagtgat
attaattttgaaaaagtaacaaacatcgctatcggttacgaaatgcaggataattcagat
cataatcacattgaagtgcagattaacagtgaactcgtaccgcgttggtatgtagaatat
gatggcgaatggtatgtttataacgatgggaggcttgaa
8.
atgagtaaaagacagaaagcatttcatgacagcttagcaaacgaaaaaacaagagtaaga
ctttataaatctggaaaaaattgggtaaaatccggaattaaagaaatagaaatgttcaaa
attatggggctaccatttattagtcatagtttagtgagtcaagataatcaaagcattagt
aaaaaaatgacgggatacggactgaaaactacggcggttattggtggtgcattcacggta
aatatgttgcatgaccagcaagcttttgcggcttctgatgcaccattaacttctgaatta
aacacacaaagtgaaacagtaggtaatcaaaactcaacgacaatcgaagcatcaacatca
acagccgattccacaagtgtaacgaaaaatagtagttcggtacaaacatcaaatagtgac
acagtctcaagtgaaaagtctgaaaaggtcacttcgacaactaatagtacaagcaatcaa
caagagaaattgacatctacatcagaatcaacatcctcaaagaatactacatcaagttct
gatactaaatctgtagcttcaacttcaagtacagaacaaccaattaatacatcaacaaat
caaagtactgcatcaaataacacttcacaaagcacaacgccatcttcggtcaacttaaac
aaaactagcacaacgtcaactagcaccgcaccagtaaaacttcgaactttcagtcgctta
gctatgtcaacatttgcgtcagcagcgacgacaaccgcagtaactgctaatacaattaca
gttaataaagataacttaaaacaatatatgacaacgtcaggtaatgctacctatgatcaa
agtaccggtattgtgacgttaacacaggatgcatacagccaaaaaggtgctattacatta
ggaacacgtattgactctaataagagttttcatttttctggaaaagtaaatttaggtaac
aaatatgaagggcatggaaatggtggagatggtatcggttttgccttttcaccaggtgta
ttaggtgaaacagggttaaacggtgccgcagtaggtattggtggcttaagtaacgcattt
ggcttcaaattggatacgtatcacaatacatctaaaccaaattcagctgcaaaggcgaat
gctgacccatctaatgtagctggtggaggtgcgtttggtgcatttgtaacaacagatagt
tatggtgttgcgacaacgtatacatcaagttcaacagctgataatgctgcgaagttaaat
gttcaacctacaaataacacgttccaagattttgatattaactataatggtgatacaaag
gttatgactgtcaaatatgcaggtcaaacatggacacgtaatatttcagattggattgcg
aaaagtggtacgaccaacttttcattatcaatgacagcctcaacaggtggcgcgacaaat
ttacaacaagtacaatttggaacattcgaatatacagagtctgctgttacacaagtgaga
tacgttgatgtaacaacaggtaaagatattattccaccaaaaacatattcaggaaatgtt
gatcaagtcgtgacaatcgataatcagcaatctgcattgactgctaaaggatataactac
acgtccgtcgatagttcatatgcgtcaacttataatgatacaaataaaactgtaaaaatg
acgaatgctggacaatcagtgacatattattttactgatgtaaaagcaccaactgtaact
gtaggcaatcaaaccatagaagtgggtaaaacaatgaatcctattgtattgactacaacg
gataatggtactgggactgtgacaaatacagttacaggattaccaagcggattaagttac
gatagtgcaacgaattcaatcattgggacaccaacaaaaattggtcaatcaacagtgaca
gttgtgtctactgaccaagcaaataacaaatcgacgacaacttttacaataaatgttgtg
gatacgacagcaccaacagtgacaccaataggagatcaatcatcagaagtgtattcacca
atatccccgattaaaattgctacgcaagataacagtggaaatgcggtgacgaatacagtg
actggattgccatccggactaacatttgatagtacaaataatactattagtggtacacca
acaaacattggtacaagtactatatcaatcgtttctacagatgcgagcggtaacaaaacg
acgacaacttttaaatatgaagtaacaagaaatagcatgagtgattccgtatcaacatca
ggaagtacacaacaatctcaaagtgtgtcaacaagtaaagctgactcacaaagtgcatca
acgagtacatcaggatcgattgtggtatctacatcagctagtacctcgaaatcgacaagt
gtaagcctatctgattctgtgagtgcatctaagtcattaagcacatctgaaagtaatagt
gtatcaagctcaacaagcacaagtttagtgaattcacaaagtgtatcatcaagcatgtcg
gattcagctagtaaatcaacatcattaagcgattctatttcaaactctagcagtactgaa
aaatccgaaagtctatcaacaagtacatctgattcattgcgtacatcaacatcactcagt
gactcattaagtatgagtacatcaggaagcttgtctaagtcacaaagcttatcaacgagt
atatcagggtcgtctagtacatcagcatcattaagtgacagtacatcgaatgcaattagt
acatcaacatcattgagcgagtcagctagcacctcggactctatcagtatttcaaatagc
atagccaactctcaaagtgcgtcaacaagcaaatcagattcacaaagtacatcaatatca
ttaagtacaagtgattcaaaatcgatgagtacatcagaatcattgagcgattcgacgagc
acaagtggttctgtttctggatcactaagcatagcagcatcacaaagtgtctcaacaagt
acatcagactcgatgagtacttcagagatagtaagtgactctatcagtacaagtgggtca
ttatctgcatcagacagtaaatcaatgtccgtaagtagttcaatgagcacgtctcagtca
ggtagtacatcagaatcattaagtgattcacaaagtacatctgattctgatagtaagtca
ttatcacaaagtactagtcaatcaggttcaacaagtacatcaacgtcgacaagtgcttca
gtacgtacttcggaatcacaaagtacgtctggttcaatgagtgcaagtcaatccgattca
atgagcatatcaacgtcgtttagtgattcaacgagtgatagcaaatcagcatcaactgca
tcaagtgaatcaatatcacaaagtgcttctacgagcacatctggttcggtaagtacttcg
acatcgttaagtacaagtaattcagaacgtacatcaacatctatgagtgattccacaagc
ttaagtacatcagagtctgattcaataagtgaatcaacgtcaacgagcgactctataagt
gaagcaatatctgcttcagagagcacgtttatatcattaagtgaatcaaatagtactagc
gattcagaatcacaaagtgcatctgcctttttaagtgaatcattaagtgaaagtacgtct
gaatcaacatcagagtcagtgagtagttcgacaagtgagagtacgtcattatcagacagt
acatcagaatctggtagcacatcaacatcattaagtaattcaacaagtggtagtacgtcc
atttcaacatcgacaagtatcagtgaatcaacgtcaacgtttaagagcgagagtgtttca
acatcactgagtatgtcaacgagtacaagtttgtctgactctacaagtttgtcaacatca
ttaagtgattccacaagtgatagtaagtctgattcattaagtacatcaatgtcgacaagt
gattcaatcagtacaagtaaatctgattccattagtacatccacatcattaagtggttct
acaagtgaaagtaaatccgattcaacatcaatgagcataagtatgtctcaatcaacatca
ggaagtacaagtacgtcaacgagtacaagtttgtctgactcaacgagtacatcattgtca
ctaagtgcctcaatgaatcaaagcggagtagactcaaactcagcaagccaaagtgcctca
aactcaacaagtacaagcacgagcgaatccgattcacaaagcacatcatcatatacaagt
cagtcaacaagccaaagtgaatccacatcgacatcaacgtcactaagcgattcaacaagt
atatctaaaagtacgagtcaatcaggttcggtaagcacatcagcgtcattaagtggttca
gagagtgaatctgattcacaaagtatctcaacaagtgcaagtgagtcaacatcagaaagt
gcgtcaacatcactcagtgactcaacaagtacaagtaactcaggatcagcaagtacgtca
acatcgctcagtaactcagcaagcgcaagtgaatccgatttgtcgtcaacatctttaagt
gattcaacatctgcgtcaatgcaaagcagtgaatccgattcacaaagcacatcagcatca
ttaagtgattcgctaagtacatcaacttcaaaccgcatgtcgaccattgcaagtttatct
acatcggtaagtacatcagagtctggctcaacatcagaaagtacaagtgaatccgattca
acatcaacatcattaagcgattcacaaagcacatcaagaagtacaagtgcatcaggatca
gcaagtacatcaacatcaacaagtgactctcgtagtacatcagcttcaactagtacttcg
atgcgtacaagtactagtgattcacaaagtatgtcgctttcgacaagtacatcaacaagt
atgagtgattcaacgtcattatctgatagtgttagtgattcaacatcagactcaacaagt
gcgagtacatctggttcgatgagtgtgtctatatcgttaagtgattcgacaagtacatca
acatcggctagtgaagtaatgagcgcaagcatatctgattcacaaagtatgtcagaatct
gtaaatgattcagaaagtgtaagtgaatctaattctgaaagtgactctaaatcgatgagt
ggctcaacaagtgtcagtgattctggctcattgagcgtctcaacgtcattaagaaaatca
gaaagtgtaagcgagtcaagttcattgagttgctcacaatcgatgagcgattcagtaagc
acaagcgattcgtcatcattaagtgtatcgacgtcactaagaagttcagaaagcgtgagt
gaatctgattcattaagtgattcaaaatcaacaagtggttcgacttcaacaagtacatct
ggttcattgagtacctcaacatcattaagtggttcagaaagcgtaagcgagtctacctcg
ctaagtgattcaatatcaatgagtgattctactagtacaagtgactccgactcattaagt
ggatcaatatctttaagtggttccacaagtcttagcacttcggattcattaagtgattca
aaatcattgagtagctcgcaaagtatgagtggatcagaatcaacgtcaacaagtgtgagc
gattcgcagtcaagctcaacaagtaatagtcaatttgactctatgagcatcagtgcatca
gaaagcgactcaatgtctacaagtgattcgtctagcatcagtggatcaaattcaacgagt
acatcactttcaacatctgactcaatgagcggaagcgtatcagtttcaacatcgacaagt
ttaagtgactcaatatcaggttcaacaagtgtaagtgactcgagctcaacaagcacatct
acatcattaagtgattcaatgtcacaaagccagtcaacaagtacaagtgcatctggttcc
ttaagtacatcgatatcaacatcaatgtcaatgagtgctagtacatcgtcatcacaaagc
acatcggtgtcgacatcattatcaacatcagacagtatcagtgattctacttcaataagt
atcagtggttcacaaagtacagtagaatcagaatctacaagtgattcaacttctatcagt
gactcagaatcattgagtacatcagattcagactcgacatcgacaagtacatcggactca
acaagtggttcaacttcaacaagcatatctgaatcattaagtacgtctggttcaggttca
acgagcgtatctgactcaacatcaatgagtgaatctaattcatcgagtgtttcaatgtca
caagacaaatccgactcaacatcaattagtgactcagaatcagtgtcaacaagcacatca
acgtcattgagcacatccgattcgacaagcacatccgaatcactgagtacatctatgtct
ggttcacaaagcatttctgactcaacatcaacaagtatgtccggctcaacaagtacatct
gaatctaactcaatgcatccgtcagactcaatgagtatgcatcatactcacagcacgagc
acatctcgcttatcaagtgaagcaacaacgagcacgagtgaatctcagtctacattaagt
gcaacatctgaagtgactaaacataatggcacaccagcacaaagtgaaaaaagattgcca
gatacaggtgactcaataaaacaaaatggattactaggtggcgttatgacattattagtt
ggtttaggtttaatgaagagaaagaaaaagaaagatgaaaatgatcaagatgattctcaa
gca
9.
atgcctaaaaataaaattttaatttatttgctatcaactacgctcgtattacctacttta
gtttcacctaccgcttatgctgatacacctcaaaaagatactacagctaagacaacatct
catgattcaaaaaaatctaatgacgatgaaacttctaaggatactacaagtaaagatatt
gataaagcagacaaaaataatacaagtaaccaagacaataacgacaaaaaatttaaaact
atagacgacagcacttcagactctaacaatatcattgattttatttataagaatttacca
caaaccaatataaaccaattgctaaccaaaaataaatacgatgataattactcattaaca
actttaatccaaaacttattcaatttaaattcggatatttctgattacgaacaacctcgt
aatggcgaaaagtcaacaaatgattcgaataaaaacagtgacaatagcatcaaaaatgac
actgatacgcaatcatctaaacaagataaagcagacaatcaaaaagcacctaaatcaaac
aatacaaaaccaagtacatctaataagcaaccaaattcgccaaagccaacacaacctaat
caatcaaatagtcaaccagcaagtgacgataaagcaaatcaaaaatcttcatcgaaagat
aatcaatcaatgtcagattcggctttagactctattttggatcaatacagtgaagatgca
aagaaaacacaaaaagattatgcatctcaatctaaaaaagacaaaaatgaaaaatctaat
acaaagaatccacagttaccaacacaagatgaattgaaacataaatctaaacctgctcaa
tcattcaataacgatgttaatcaaaaggatacacgtgcaacatcattattcgaaacagat
cctagtatatctaacaatgatgatagcggacaatttaacgttgttgactcaaaagataca
cgtcaatttgtcaaatcaattgctaaagatgcacatcgcattggtcaagataacgatatt
tatgcgtctgtcatgattgcccaagcaatcttagaatctgactcaggtcgtagtgcttta
gctaagtcaccaaaccataatttattcggtatcaaaggtgcttttgaagggaattctgtt
ccttttaacacattagaagctgatggtaatcaattgtatagtattaatgctggattccga
aaatatccaagcacgaaagaatcactaaaagattactctgaccttattaaaaatggtatt
gatggcaatcgaacaatttataaaccaacatggaaatcggaagccgattcttataaagat
gcaacatcacacttatctaaaacatatgctacagatccaaactatgctaagaaattaaac
agtattattaaacactatcaattaactcagtttgacgatgaacgcatgccagatttagat
aaatatgaacgttctatcaaggattatgatgattcatcagatgaattcaaacctttccgt
gaggtatctgatagtatgccatatccacatggccaatgtacttggtacgtatataaccgt
atgaaacaatttggtacatctatctcaggtgatttaggtgatgcacataattggaataat
cgagctcaataccgtgattatcaagtaagtcatacaccaaaacgtcatgctgctgttgta
tttgaggctggacaatttggtgcagatcaacattacggtcatgtagcatttgttgaaaaa
gttaacagtgatggttctatcgttatttcagaatccaatgttaaaggattaggtatcatt
tctcatagaactatcaacgcagctgccgctgaagaattatcatatattacaggtaaa
10.
gtgaggaaattttcaagatatgcatttacaagtatggcagcattaaccttgttgagcact
ttatcaccagcagcattagcgattgattcaaaaaataaaccagctaattctgatattaaa
tttgaggtgactcaaaagagtgatgcggtcaaagcattaaaagaattgcctaaatccgaa
aatgtaaaaaatatttatcaagattacgctgttactgatgtaaaaactgataaaaaagga
tttacgcattatacattgcaaccgagtgttgatggtgttcatgcacctgacaaagaagtg
aaagtacacgcagacaaatcaggaaaagtcgttttaatcaatggggatactgatgcgaag
aaagtaaagccaacgaataaagtgacattaagtaaagatgacgcagccgacaaagcattt
aaagcagttaagattgataagaataaagcgaaaaatcttaaagataaagtcattaaagaa
aacaaagttgaaatcgatggtgacagtaataaatacgtttataatgttgagttaattaca
gtgacaccagaaatttcacattggaaagttaaaattgatgctcaaactggcgaaatttta
gaaaaaatgaacttagttaaagaagctgcagaaactggtaaaggaaaaggtgtacttggc
gatacaaaagatatcaatatcaatagtattgacggtggatttagcctagaagatttaacg
catcaaggtaaattatcagcatttagctttaatgatcaaacaggtcaagcaacattgatt
actaatgaagatgaaaacttcgtaaaagatgagcaacgtgctggcgtagatgcaaattat
tacgctaaacaaacatatgattattacaaagacacatttggtcgtgaatcatatgacaac
caaggtagtccaattgtttcattaacgcatgttaataactacggtggtcaagataacaga
aataatgccgcatggatcggtgacaaaatgatctatggtgatggtgatggtcgcacattc
acaagtttatcgggtgcaaatgacgtagtagcacacgaattaacacacggtgtgacacaa
gagacagcgaacttagaatataaggaccagtcaggcgctctaaatgaaagcttttcagat
gtttttggatactttgtagatgacgaggatttcttaatgggtgaagatgtctacacacct
ggaaaagagggagacgctttacgcagcatgtcaaacccagaacaatttggtcaaccagct
catatgaaagactatgtattcactgaaaaagataatggtggcgtacatacgaattctgga
attccaaataaagcagcttataacgtgattcaagcaatagggaaatctaaatcagaacaa
atttactaccgagcattaacggaatacttaacaagtaattcaaacttcaaagattgtaaa
gatgcattataccaagcggctaaagatttatatgacgagcaaacagctgaacaggtgtat
gaagcatggaatgaagtaggcgtggag
11.
ttgaaaaaaagaattgattatttgtcgaataagcagaataagtattcgattagacgtttt
acagtaggtaccacatcagtaatagtaggggcaactatactatttgggataggcaatcat
caagcacaagcttcagaacaatcgaacgatacaacgcaatcttcgaaaaataatgcaagt
gcagattccgaaaaaaacaatatgatagaaacacctcaattaaatacaacggctaatgat
acatctgatattagtgcaaacacaaacagtgcgaatgtagatagcacaacaaaaccaatg
tctacacaaacgagcaataccactacaacagagccagcttcaacaaatgaaacacctcaa
ccgacggcaattaaaaatcaagcaactgctgcaaaaatgcaagatcaaactgttcctcaa
gaagcaaattctcaagtagataataaaacaacgaatgatgctaatagcatagcaacaaac
agtgagcttaaaaattctcaaacattagatttaccacaatcatcaccacaaacgatttcc
aatgcgcaaggaactagtaaaccaagtgttagaacgagagctgtacgtagtttagctgtt
gctgaaccggtagtaaatgctgctgatgctaaaggtacaaatgtaaatgataaagttacg
gcaagtaatttcaagttagaaaagactacatttgaccctaatcaaagtggtaacacattt
atggcggcaaattttacagtgacagataaagtgaaatcaggggattattttacagcgaag
ttaccagatagtttaactggtaatggagacgtggattattctaattcaaataatacgatg
ccaattgcagacattaaaagtacgaatggcgatgttgtagctaaagcaacatatgatatc
ttgactaagacgtatacatttgtctttacagattatgtaaataataaagaaaatattaac
ggacaattttcattacctttatttacagaccgagcaaaggcacctaaatcaggaacatat
gatgcgaatattaatattgcggatgaaatgtttaataataaaattacttataactatagt
tcgccaattgcaggaattgataaaccaaatggcgcgaacatttcttctcaaattattggt
gtagatacagcttcaggtcaaaacacatacaagcaaacagtatttgttaaccctaagcaa
cgagttttaggtaatacgtgggtgtatattaaaggctaccaagataaaatcgaagaaagt
agcggtaaagtaagtgctacagatacaaaactgagaatttttgaagtgaatgatacatct
aaattatcagatagctactatgcagatccaaatgactctaaccttaaagaagtaacagac
caatttaaaaatagaatctattatgagcatccaaatgtagctagtattaaatttggtgat
attactaaaacatatgtagtattagtagaagggcattacgacaatacaggtaagaactta
aaaactcaggttattcaagaaaatgttgatcctgtaacaaatagagactacagtattttc
ggttggaataatgagaatgttgtacgttatggtggtggaagtgctgatggtgattcagca
gtaaatccgaaagacccaactccagggccgccggttgacccagaaccaagtccagaccca
gaaccagaaccaacgccagatccagaaccaagtccagacccagaaccggaaccaagccca
gacccggatccggattcggattcagacagtgactcaggctcagacagcgactcaggttca
gatagcgactcagaatcagatagcgattcggattcagacagtgattcagattcagacagc
gactcagaatcagatagcgattcagaatcagatagcgactcagattcagatagcgattca
gattcagatagcgattcagattcagatagcgattcggattcagacagtgattcagattca
gacagcgactcagaatcagatagcgactcagaatcagatagtgagtcagattcagacagt
gactcggactcagacagtgattcagactcagatagcgattcagactcagatagcgattca
gattcagacagcgactcagattcagacagcgactcagactcagatagcgactcagactca
gacagcgactcagattcagatagcgattcagactcagacagcgactcagactcagacagc
gactcagactcagatagcgactcagattcagatagcgattcagactcagacagcgactca
gattcagatagcgattcggactcagacagcgattcagattcagacagcgactcagactcg
gatagcgattcagattcagatagcgattcggattcagacagtgattcagattcagacagc
gactcagactcggatagcgactcagactcagacagcgattcagactcagatagcgactca
gactcggatagcgactcggattcagatagcgactcagactcagatagtgactccgattca
agagttacaccaccaaataatgaacagaaagcaccatcaaatcctaaaggtgaagtaaac
cattctaataaggtatcaaaacaacacaaaactgatgctttaccagaaacaggagataag
agcgaaaacacaaatgcaactttatttggtgcaatgatggcattattaggatcattacta
ttgtttagaaaacgcaagcaagatcataaagaaaaagcg
12.
atgaaaaagacaattatggcatcatcattagcagtggcattaggtgtaacaggttacgca
gcaggtacaggacatcaagcacacgctgctgaagtaaacgttgatcaagcacacttagtt
gacttagcgcataatcaccaagatcaattaaatgcagctccaatcaaagatggtgcatat
gacatccactttgtaaaagatggtttccaatataacttcacttcaaatggtactacatgg
tcatggagctatgaagcagctaatggtcaaactgctggtttctcaaacgttgcaggtgca
gactacactacttcatacaaccaaggttcaaatgtacaatcagtaagctacaatgcacaa
tcaagtaactcaaacgttgaagctgtttcagctccaacttaccataactacagcacttca
actacttcaagttcagtgagattaagcaatggtaatactgcaggtgctactggttcatca
gcagctcaaatcatggctcaacgtactggtgtttcagcttctacatgggctgcaatcatc
gctcgtgaatcaaatggtcaagtaaatgcttacaacccatcaggtgcttcaggtttattc
caaactatgccaggttggggtccaacaaacactgttgaccaacaaatcaacgcagctgtt
aaagcatacaaagcacaaggtttaggtgcttggggattc
13.
ttgggaggatatttaattatgaaaaaaatcgttacagctacaatcgctacagcaggactt
gccactatcgcatttgcaggacatgatgcacaagccgcagaacaaaataacaatggatat
aattctaatgacgctcaatcatacagctatacgtatacaattgatgcacaaggtaattat
cattacacttggacaggaaattggaatccaagtcaattaacgcaaaacaacacatactac
tacaacaactacaatacttatagttataacaatgcatcttacaataactactataatcat
tcatatcaatacaataactatacaaacaatagtcaaacagcaacaaataactattatact
ggtggttcaggtgcaagttatagcacaacaagtaataatgttcatgtgactacaactgca
gcgccatcttcaaatggtcgttcaatttctaatggttatgcatcaggaagtaacttatat
acttcaggacaatgtacttattatgtatttgatcgtgttggtgggaaaattggttcaaca
tggggtaacgcaagtaattgggctaacgcagctgcatcatctggctatacagtgaacaat
acaccaaaagttggtgctatcatgcaaacaacacaaggctattacggtcatgttgcttac
gttgaaggcgttaacagcaacggttctgttcgtgtttcagaaatgaactatggacatggt
gctggtgtggttacgtctcgtacaatttcagcaaaccaagcaggttcatataatttcatt
cat
14.
gtggctaatacgaaaaaaacaacattagatatcactggtatgacttgtgccgcatgttca
aatcgtatcgaaaagaaactgaataaacttgatgacgttaatgcccaagtgaatttaact
acagagaaagcaactgttgagtataaccctgatcaacatgatgtccaagaatttattaat
acgattcaacatttaggttacggtgtcgctgtagaaactgtcgaattagacattacaggt
atgacttgtgctgcatgctcaagccgtattgaaaaagtgttaaataaaatggacggcgtt
caaaatgcaacggtcaatttaacaacagagcaagctaaagttgactattatcctgaagaa
acagatgctgataaacttgtcactcgcattcaaaaattaggttatgacgcgtctattaaa
gataacaataaagatcaaacgtcacgcaaagctgaagcgctacaacataaattgattaag
cttatcatatcagcagtattatctttaccactattaatgttaatgtttgtacatcttttc
aatatgcatataccagcactatttacgaatccatggttccaatttattttagctacacct
gtacaatttattattggatggcaattttatgtaggtgcttataaaaacttaagaaatggt
ggcgccaatatggatgtacttgttgctgttggtacaagtgcagcatatttttacagtatt
tatgaaatggttcgttggctaaatggctcaacaacgcaaccgcatttatactttgaaaca
agcgccgtactaattaccttaatcttattcggtaagtatttagaagctagagcgaagtct
caaacaaccaatgcgcttggcgaattattaagtttacaagctaaagaagcacgcatttta
aaagatggtaatgaagtgatgattcctctaaatgaagtacatgttggagatacacttatc
gttaaaccaggtgaaaagatacctgttgatggcaaaattattaaaggtatgactgccatc
gacgaatctatgttaacaggtgaatctatccctgttgagaagaatgttgatgatactgta
attggttcaacgatgaacaaaaacggtactattactatgacagcaacaaaagttggcggg
gacaccgcgttggcaaatattattaaagttgtcgaagaagctcaaagttctaaagcgccg
attcaacgattggcagatattatttctggttatttcgttcctatcgttgttggtatcgca
ctattaacatttatcgtgtggattactttagttacaccaggtacatttgaacctgcactt
gttgcgagtatttccgttctcgtcattgcttgtccatgcgcattgggacttgctacacca
acttctattatggtaggtactggtcgcgctgctgaaaatggtattttatttaaaggtggc
gagtttgttgaacgcacacatcaaattgataccatcgttttagataagacgggtaccatt
acaaatggtcgtccagtcgtgacagattatcatggtgacaatcaaacgctacaactactt
gctactgctgaaaaagattctgaacacccattggcagaagccattgtcaattatgcaaaa
gaaaagcaattaatattaactgagacaacaacatttaaagcagtacctggccatggtatt
gaagcaacgattgatcatcaccatatattggttggtaaccgtaaattaatggctgacaat
gatattagcttgcctaagcatatttctgatgatttaacacattatgaacgagatggtaaa
actgctatgctcattgctgttaattattcattaactggtatcatcgcagtggcagatact
gtcaaagatcatgccaaagatgctataaaacaattgcatgatatgggcattgaagttgcc
atgttaactggcgataataaaaacactgctcaagccattgcaaaacaagtaggcatagat
actgttattgcagatattttaccagaagaaaaagctgcacaaattgcgaaactacagcaa
caaggtaagaaggttgcgatggttggtgacggtgtaaatgatgcacctgcattagttaaa
gctgatatcggtatcgccattggtacaggtacagaagttgccattgaagcagctgatatt
actattcttggtggcgacttgatgcttattcctaaagccatttatgcaagtaaagcaacc
attcgtaatattcgtcaaaatctattttgggcattcggctataatattgccggtatccct
atagctgcattgggcttacttgcgccatgggttgctggtgctgcaatggcactaagttca
gtaagtgttgtcacaaacgcacttagattgaaaaagatgcgattagaaccacgccgtaaa
gatgcc
15.
atgtttgattcaattagagagactatagattatgccgtagaaaataatatgtcatttgcg
gatatcatggttaaagaagaaatggaattaagcggtaaatcacgtgatgaagtgcgagcg
caaatgaaacaaaatttagatgtcatgcgagacgcagtaatcaaagggacgacaggtgat
ggggttgaaagtgtaacgggctacactggtcatgatgctgctaaactacgtgattataat
gaaacacatcatgctttgtctggatatgaaatgattgacgcagtcaaaggtgccattgca
acaaatgaagtcaatgctgcgatgggtattatttgtgcaacgccaacagctggttcctcg
ggtaccattcccggtgcactttttaaattagaaaaaacacatgatttaacagaagagcaa
atgattgatttcttattcacttcagcattgtttgggcgtgtcgtagcaaacaatgcaagt
gtagctggtgcaacaggtggctgccaagctgaagttggttcagcatctgcaatggccgca
gctgcagcagtagctatattcggaggatcaccagaagcatccgggcacgctatggcatta
gcgataagtaatttattaggtttagtttgtgatccagtagccggacttgttgaaattcct
tgtgttatgagaaatgcaattggttcgggtaacgctttaatttcagcagatttagcatta
gcaggtattgaaagtagaatccctgttgatgaagttattgaagcaatggataaggttggt
cgtaaccttcctgcatcattacgtgaaactggattgggtggactagcaggcacaccaact
ggcgaagcaattaaacgtaaaatctttggcacagctgaagatatggttaaaaataat
16.
gtgaaaaacaatcttaggtacggcattagaaaacataaattgggagcagcatcagtattc
ttaggaacaatgatcgttgttgggatgggacaagacaaagaagctgcagcatcagaacaa
aagacaactacagtagaagaaaatgggaattcagctactgataataaaacaagtgaaaca
caaacaactgcaactaacgttaatcatatagaagaaactcaatcatataacgcaacagta
acagaacaaccgtcaaacgcaacacaagtaacaactgaagaagcaccaaaagcagtacaa
gcaccacaaactgcacaaccagcaaatatagaaacagttaaagaagaggtagttaaggaa
gaagcgaaacctcaagttaaggaaacaacacaatctcaagacaatagcggagatcaaaga
caagtagatttaacacctaaaaaggctacacaaaatcaagtcgcagaaacacaagttgaa
gtggcacagccaagaacggcatcagaaagtaagccacgtgtgacaagatcagcagatgta
gcggaagctaaggaagctagtaacgcgaaagtggaaacgggtacagatgtaacaagtaaa
gttacagtagaaattggttctattgaggggcataacaatacaaataaagtagaacctcat
gcaggacaacgagcggtactaaaatataagttgaaatttgagaatggtttacatcaaggt
gactactttgactttactttatcaaataatgtaaatacgcatggcgtatcaactgctaga
aaagtaccagaaattaaaaatggttcagtcgtaatggcgacaggtgaagttttagaaggt
ggaaagattagatatacatttacaaatgatattgaagataaggttgatgtaacggctgaa
ctagaaattaatttatttattgatcctaaaactgtacaaactaatggaaatcaaactata
acttcaacactaaatgaagaacaaacttcaaaggaattagatgttaaatataaagatggt
attgggaattattatgccaatttaaatggatcgattgagacatttaataaagcgaataat
agattttcgcatgttgcatttattaaacctaataatggtaaaacgacaagtgtgactgtt
actggaactttaatgaaaggtagtaatcagaatggaaatcaaccaaaagttaggatattt
gaatacttgggtaataatgaagacatagcgaagagtgtatatgcaaatacgacagatact
tctaaatttaaagaagtcacaagtaatatgagtgggaatttgaatttacaaaataatgga
agctattcattgaatatagaaaatctagataaaacttatgttgttcactatgatggagag
tatttaaatggtactgatgaagttgattttagaacacaaatggtaggacatccagagcaa
ctttataagtattattatgatagaggatataccttaacttgggataatggtttagtttta
tacagtaataaagcgaacggaaatgggaaaaatggtccgattattcaaaataataaattt
gaatataaagaagatacaattaaagaaactcttacaggtcaatatgataagaatttagta
actactgttgaagaggaatatgattcatcaactcttgacattgattaccacacagctata
gatggtggaggtggatatgttgatggatacattgaaacaatagaagaaacggattcatca
gctattgatatcgattaccatactgctgtggatagcgaagcaggtcacgttggaggatac
actgagtcctctgaggaatcaaatccaattgactttgaagaatctacacatgaaaattca
aaacatcacgctgatgttgttgaatatgaagaagatacaaacccaggtggtggtcaggtt
actactgagtctaacttagttgaatttgacgaagagtctacaaaaggtattgtaactggc
gcagtgagcgatcatacaacagttgaagatacgaaagaatatacaactgaaagtaatctg
attgaattagtggatgaattacctgaagagcatggtcaagcacaaggaccagtcgaggaa
attactgaaaacaatcatcatatttctcattctggtttaggaactgaaaatggtcacggg
aattatgacgtgattgaagaaatcgaagaaaatagccacgttgatattaagagtgaatta
ggttatgaaggtggccaaaatagcggtaaccagtcattcgaggaagacacagaagaagac
aaacctaaatatgaacaaggtggcaatatcgtagatatcgattttgatagtgtacctcaa
attcatggtcaaaataaaggtaatcagtcattcgaggaagatacagaaaaagacaaacct
aagtatgaacatggcggtaacatcattgatatcgacttcgacagtgtgccacatattcac
ggattcaataagcacactgaaattattgaagaagatacaaataaagataaaccaagttat
caattcggtggacacaatagtgttgactttgaagaagatacacttccaaaagtaagcggc
caaaatgaaggtcaacaaacgattgaagaagatacaacacctccaatcgtgccaccaacg
ccaccgacaccagaagtaccaagtgagccggaaacaccaacgccaccaacaccagaagta
ccaagtgagccggaaacaccaacaccaccgacaccagaagtgccgagtgagccagaaact
ccaacaccgccaacaccagaggtaccagctgaacctggtaaaccagtaccacctgccaaa
gaagaacctaaaaagccttctaaaccagtggaacaaggtaaagtagtaacacctgttatt
gaaatcaatgaaaaggttaaagcagtggcaccaactaaaaaaccacaatctaagaaatct
gaactacctgaaacaggtggagaagaatcaacaaacaaaggtatgttgttcggcggatta
ttcagcattctaggtttagcattattacgcagaaataaaaagaatcacaaagca
17.
ttgcatttaagggagaatattatagtgaaaagcaatcttagatacggcataagaaaacac
aaattgggagcggcctcagtattcttaggaacaatgatcgttgttggaatgggacaagaa
aaagaagctgcagcatcggaacaaaacaatactacagtagaggaaagtgggagttcagct
actgaaagtaaagcaagcgaaacacaaacaactacaaataacgttaatacaatagatgaa
acacaatcatacagcgcgacatcaactgagcaaccatcacaatcaacacaagtaacaaca
gaagaagcaccgaaaactgtgcaagcaccaaaagtagaaacttcgcgagttgatttgcca
tcggaaaaagttgctgataaggaaactacaggaactcaagttgacatagctcaaccaagt
aacgtctcagaaattaaaccaagaatgaaaagatcaactgacgttacagcagttgcagag
aaagaagtagtggaagaaactaaagcgacaggtacagatgtaacaaataaagtggaagta
gaagaaggtagtgaaattgtaggacataaacaagatacgaatgttgtaaatcctcataac
gcagaaagagtaaccttgaaatataaatggaaatttggagaaggaattaaggcgggagat
tattttgatttcacattaagcgataatgttgaaactcatggtatctcaacactgcgtaaa
gttccggagataaaaagtacagatggtcaagttatggcgacaggagaaataattggagaa
agaaaagttagatatacgtttaaagaatatgtacaagaaaagaaagatttaactgctgaa
ttatctttaaatctatttattgatcctacaacagtgacgcaaaaaggtaaccaaaatgtt
gaagttaaattgggtgagactacggttagcaaaatatttaatattcaatatttaggtgga
gttagagataattggggagtaacagctaatggtcgaattgatactttaaataaagtagat
gggaaatttagtcattttgcgtacatgaaacctaacaaccagtcgttaagctctgtgaca
gtaactggtcaagtaactaaaggaaataaaccaggggttaataatccaacagttaaggta
tataaacacattggttcagacgatttagctgaaagcgtatatgcaaagcttgatgatgtc
agcaaatttgaagatgtgactgataatatgagtttagattttgatactaatggtggttat
tctttaaactttaataatttagaccaaagtaaaaattatgtaataaaatatgaagggtat
tatgattcaaatgctagcaacttagaatttcaaacacacctttttggatattataactat
tattatacaagtaatttaacttggaaaaatggcgttgcattttactctaataacgctcaa
ggcgacggcaaagataaactaaaggaacctattatagaacatagtactcctatcgaactt
gaatttaaatcagagccgccagtggagaagcatgaattgactggtacaatcgaagaaagt
aatgattctaagccaattgattttgaatatcatacagctgttgaaggtgcagaaggtcat
gcagaaggtaccattgaaactgaagaagattctattcatgtagactttgaagaatcgaca
catgaaaattcaaaacatcatgctgatgttgttgaatatgaagaagatacaaacccaggt
ggtggtcaggttactactgagtctaacctagttgaatttgacgaagattctacaaaaggt
attgtaactggtgctgttagcgatcatacaacaattgaagatacgaaagaatatacgact
gaaagtaatctgattgaactagtagatgaactacctgaagaacatggtcaagcgcaagga
ccaatcgaggaaattactgaaaacaatcatcatatttctcattctggtttaggaactgaa
aatggtcacggtaattatggcgtgattgaagaaatcgaagaaaatagccacgtggatatt
aagagtgaattaggttacgaaggtggccaaaatagcggtaatcagtcatttgaggaagac
acagaagaagataaaccgaaatatgaacaaggtggcaatatcgtagatatcgatttcgat
agtgtacctcaaattcatggtcaaaataatggtaaccaatcattcgaagaagatacagag
aaagacaaacctaagtatgaacaaggtggtaatatcattgatatcgacttcgacagtgtg
ccacatattcacggattcaataagcacactgaaattattgaagaagatacaaataaagat
aaaccaaattatcaattcggtggacacaatagtgttgactttgaagaagatacacttcca
caagtaagtggtcataatgaaggtcaacaaacgattgaagaagatacaacacctccaatc
gtgccaccaacgccaccgacaccagaagtaccaagcgagccggaaacaccaacaccaccg
acaccagaagtaccaagcgagccggaaacaccaacaccgccaacgccagaggtaccaact
gaacctggtaaaccaataccacctgctaaagaagaacctaaaaaaccttctaaaccagtg
gaacaaggtaaagtagtaacacctgttattgaaatcaatgaaaaggttaaagcagtggta
ccaactaaaaaagcacaatctaagaaatctgaactacctgaaacaggtggagaagaatca
acaaacaacggcatgttgttcggcggattatttagcattttaggtttagcgttattacgc
agaaataaaaagaatcacaaagca
18.
atgcaaatgagagataagaaaggaccggtaaataaaagagtagattttctatcaaataaa
ttgaataaatattcaataagaaaatttacagttggaacagcatctattttaattggctca
ctaatgtatttgggaactcaacaagaggcagaagcagctgaaaacaatattgagaatcca
actacattaaaagataatgtccaatcaaaagaagtgaagattgaagaagtaacaaacaaa
gacactgcaccacagggtgtagaagctaaatctgaagtaacttcaaacaaagacacaatc
gaacatgaaccatcagtaaaagctgaagatatatcaaaaaaggaggatacaccaaaagaa
gtagctgatgttgctgaagttcagccgaaatcgtcagtcactcataacgcagagacacct
aaggttagaaaagctcgttctgttgatgaaggctcttttgatattacaagagattctaaa
aatgtagttgaatctaccccaattacaattcaaggtaaagaacattttgaaggttacgga
agtgttgatatacaaaaaaaaccaacagatttaggggtatcagaggtaaccaggtttaat
gttggtaatgaaagtaatggtttgataggagctttacaattaaaaaataaaatagatttt
agtaaggatttcaattttaaagttagagtggcaaataaccatcaatcaaataccacaggt
gctgatggttgggggttcttatttagtaaaggaaatgcagaagaatatttaactaatggt
ggaatccttggggataaaggtctggtaaattcaggcggatttaaaattgatactggatac
atttatacaagttccatggacaaaactgaaaagcaagctggacaaggttatagaggatac
ggagcttttgtgaaaaatgacagttctggtaattcacaaatggttggagaaaatattgat
aaatcaaaaactaattttttaaactatgcggacaattcaactaatacatcagatggaaag
tttcatgggcaacgtttaaatgatgtcatcttaacttatgttgcttcaactggtaaaatg
agagcagaatatgctggtaaaacttgggagacttcaataacagatttaggtttatctaaa
aatcaggcatataatttcttaattacatctagtcaaagatggggccttaatcaagggata
aatgcaaatggctggatgagaactgacttgaaaggttcagagtttacttttacaccagaa
gcgccaaaaacaataacagaattagaaaaaaaagttgaagagattccattcaagaaagaa
cgtaaatttaatccggatttagcaccagggacagaaaaagtaacaagagaaggacaaaaa
ggtgagaagacaataacgacaccaacactaaaaaatccattaactggagtaattattagt
aaaggtgaaccaaaagaagagattacaaaagatccgattaatgaattaacagaatacgga
cctgaaacaatagcgccaggtcatcgagacgaatttgatccgaagttaccaacaggagag
aaagaggaagttccaggtaaaccaggaattaagaatccagaaacaggagacgtagttaga
ccgccggtcgatagcgtaacaaaatatggacctgtaaaaggagactcgattgtagaaaaa
gaagarattccattcragaaagaacgtaaatttaatccggatttagcaccagggacagaa
aaagtaacaagagaaggacaaaaaggtgagaagacaataacgacgccaacactaaaaaat
ccattaactggagaaattattagtaaaggtgaatcgaaagaagaaatcacaaaagatccg
attaatgaattaacagaatacggaccagaaacgataacaccaggtcatcgagacgaattt
gatccgaagttaccaacaggagagaaagaggaagttccaggtaaaccaggaattaagaat
ccagaaacaggagacgtagttagaccaccggtcgatagcgtaacaaaatatggacctgta
aaaggagactcgattgtagaaaaagaagaaattccattcaagaaagaacgtaaatttaat
cctgatttagcaccagggacagaaaaagtaacaagagaaggacaaaaaggtgagaagaca
ataacgacgccaacactaaaaaatccattaactggagaaattattagtaaaggtgaatcg
aaagaagaaatcacaaaagatccgattaatgaattaacagaatacggaccagaaacgata
acaccaggtcatcgagacgaatttgatccgaagttaccaacaggagagaaagaggaagtt
ccaggtaaaccaggaattaagaatccagaaacaggagatgtagttagaccaccggtcgat
agcgtaacaaaatatggacctgtaaaaggagactcgattgtagaaaaagaagaaattcca
ttcgagaaagaacgtaaatttaatcctgatttagcaccagggacagaaaaagtaacaaga
gaaggacaaaaaggtgagaagacaataacgacgccaacactaaaaaatccattaactgga
gaaattattagtaaaggtgaatcgaaagaagaaatcacaaaagatccagttaatgaatta
acagaattcggtggcgagaaaataccgcaaggtcataaagatatctttgatccaaactta
ccaacagatcaaacggaaaaagtaccaggtaaaccaggaatcaagaatccagacacagga
aaagtgatcgaagagccagtggatgatgtgattaaacacggaccaaaaacgggtacacca
gaaacaaaaacagtagagataccgtttgaaacaaaacgtgagtttaatccaaaattacaa
cctggtgaagagcgagtgaaacaagaaggacaaccaggaagtaagacaatcacaacacca
atcacagtgaacccattaacaggtgaaaaagttggcgagggtcaaccaacagaagagatc
acaaaacaaccagtagataagattgtagagttcggtggagagaaaccaaaagatccaaaa
ggacctgaaaacccagagaagccgagcagaccaactcatccaagtggcccagtaaatcct
aacaatccaggattatcgaaagacagagcaaaaccaaatggcccagttcattcaatggat
aaaaatgataaagttaaaaaatctaaaattgctaaagaatcagtagctaatcaagagaaa
aaacgagcagaattaccaaaaacaggtttagaaagcacgcaaaaaggtttgatctttagt
agtataattggaattgctggattaatgttattggctcgtagaagaaagaat
19.
atgaaaaataaatatatctcgaagttgctagttggggcagcaacaattacgttagctaca
atgatttcaaatggggaagcaaaagcgagtgaaaacacgcaacaaacttcaactaagcac
caaacaactcaaaacaactacgtaacagatcaacaaaaagctttttatcaagtattacat
ctaaaaggtatcacagaagaacaacgtaaccaatacatcaaaacattacgcgaacaccca
gaacgtgcacaagaagtattctctgaatcacttaaagacagcaagaacccagaccgacgt
gttgcacaacaaaacgctttttacaatgttcttaaaaatgataacttaactgaacaagaa
aaaaataattacattgcacaaattaaagaaaaccctgatagaagccaacaagtttgggta
gaatcagtacaatcttctaaagctaaagaacgtcaaaatattgaaaatgcggataaagca
attaaagatttccaagataacaaagcaccacacgataaatcagcagcatatgaagctaac
tcaaaattacctaaagatttacgtgataaaaacaaccgctttgtagaaaaagtttcaatt
gaaaaagcaatcgttcgtcatgatgagcgtgtgaaatcagcaaatgatgcaatctcaaaa
ttaaatgaaaaagattcaattgaaaacagacgtttagcacaacgtgaagttaacaaagca
cctatggatgtaaaagagcatttacagaaacaattagacgcattagttgctcaaaaagat
gctgaaaagaaagtggcgccaaaagttgaggctcctcaaattcaatcaccacaaattgaa
aaacctaaagtagaatcaccaaaagttgaagtccctcaaattcaatcaccaaaagttgag
gttcctcaatctaaattattaggttactaccaatcattaaaagattcatttaactatggt
tacaagtatttaacagatacttataaaagctataaagaaaaatatgatacagcaaagtac
tactataatacgtactataaatacaaaggtgcgattgatcaaacagtattaacagtacta
ggtagtggttctaaatcttacatccaaccattgaaagttgatgataaaaacggctactta
gctaaatcatatgcacaagtaagaaactatgtaactgagtcaatcaatactggtaaagta
ttatatactttctaccaaaacccaacattagtaaaaacagctattaaagctcaagaaact
gcatcatcaatcaaaaatacattaagtaatttattatcattctggaaa
20.
atggccgtattttcaaaagagaaaaagagaggatgtatcgttgtgatagaaacatttaaa
gcgtttgtaattgataaagatgagagtggtaaagtgacaccaactttcaaacaattatcg
cctactgatttacctaaaggagatgtgctgattaaagtacattactctggtataaattat
aaagatgctttagcgactcaagaccataatgcagtcgtaaaatcgtatcctatgattcca
ggaatagatttagctggaacaattgttgaatccgaagcaccaggctttgaaaaaggagaa
caagtaattgtaacgagttatgacctaggtgtcagccattatggcggttttagtgaatat
gcgcgtgtaaaatcagaatggattatcaagcttcctgatactttaacattagaagaatca
atgatatatggcacagctggttatactgccggtttagcaattgaaagacttgaaaaagtt
ggaatgaatattgaagatggtcctgtactcgttcgcggtgcttcaggtggtgtcggtact
ttagcagtactcatgcttaatgaacttggttataaagttatcgcaagtacaggtaaacaa
gatgttagcgatcaattacttgaacttggtgccaaagaagttatcgatcgacttcctgtt
gaagatgatcataaaaagccactcgcatcatcaacttggcaagcttgtgtagaccctgtt
ggtggcgaaggtattaattatgttacaaagcgtttaaatcatagtgggtcaattgcagtt
attggtatgactgccggtaatacttatactaattctgtattccctcacattttaagaggt
gtaaacattttaggaattgactcggtatttactgctatgaaattaagacagcgcgtttgg
cgtcgtctcgcaaaagatttaatgcctgaaaatttacatgagatcaagcaagttattaca
tttgatgaacttccagaacaacttaacaaagtaattaaacatgaaaataaagggcgcatt
gttatcgatttcggtgtagataaa
21.
atgaaaaaattagtaacagcaactacgttaacagcaggaatcggcacagcattagtaggt
caagcatatcatgcagatgctgctgaaaattatacaaattacaacaactataactacaac
acgactcaaactacaacgactacgacaactacgacaactacatcatcaatttcacattct
ggtaacttatacactgcaggacaatgtacttggtatgtatatgataaagttggcggagaa
atcggttctacttggggaaatgctaataattgggctgctgctgcacaaggtgctggattc
acagtaaatcatacaccttctaaaggcgctatcctacaatcttctgaaggaccatttggt
cacgttgcatatgtagaaagtgtaaacagtgatggttcagttacaatttcagaaatgaat
tatagtggcggacctttctcagtaagttctagaactatttctgcaagtgaagcaggtaac
tacaactacatccatatt
22.
atgaagaaaatcgctacagctactatcgcaactgcaggattcgctacaatcgcaattgca
tcaggaaatcaagctcatgcttctgagcaagataactacggttataatccaaacgaccca
acatcatatagctatacttacactattgatgcacaaggtaactaccattacacatggaaa
ggtaactggcatccaagtcaattaaaccaagataatggctactacagctattactactac
aatggttacaataactataacaattacaacaacggttatagctacaataactacagccgt
tacaacaactactcaaataataatcaatcatataactacaataactataatagttacaac
acaaacagctaccgtactggtggtttaggtgcaagctacagcacttcaagcaacaatgtt
caagtaactacaactatggctccatcatcaaatggccgttcaatctcaagtggttatact
tcaggacgtaacttatacacttctggtcaatgtacatactacgtatttgatcgtgtaggt
ggtaaaatcggttcaacttggggcaatgcaagtaactgggctaacgcagctgcaagagct
ggttacacagtgaacaatacaccaaaagctggtgcaattatgcaaacaactcaaggtgca
tacggtcacgttgcatacgttgaaagtgttaacagcaatggttcagtaagagtttcagaa
atgaactatggttatggcccaggtgttgtaacttcacgtacaatctcagctagccaagct
gctggttataacttcattcac
23.
atgtcaatgacatatagaataaagaaatggcaaaaattatccaccattacgttattaatg
gctggtgtgattactttgaatggtggtgaattcagaagtgttgataaacatcaaatcgct
gtggctgatacgaatgttcaaacgccagattatgaaaaattgaggaacacatggctggac
gttaactatggttatgataagtatgatgagaataatccagatatgaagaagaagtttgat
gctacagagaaagaggcgacgaatttactcaaggaaatgaaaactgaaagtggtaggaaa
tacttgtggtcaggagcggaaacccttgaaactaattcttctcatatgactcgtacctat
cgtaatattgagaaaatcgcagaagcgatgaggaatcctaaaaccactttaaatactgac
gaaaataagaagaaagtgaaagatgcccttgagtggctgcataaaaatgcatatggaaaa
gaaccagataaaaaagtaaaagaattaagtgagaattttactaaaacaactggcaagaat
accaacttaaattggtgggattatgaaattggaacacctaaatcattaacaaatacgctt
atattgctgaatgatcaattttcaaatgaagaaaagaaaaaattcactgcccctattaaa
actttcgccccagatagtgacaaaatattatcttctgtaggaaaagctgaacttgctaaa
ggcggaaatctagtagacatttctaaggtgaaacttttagaatgtattatcgaagaagat
aaagatatgatgaaaaagtctatagattcatttaataaagtcttcactwacgttcaagat
tctgccactggtaaagaacgtaatggattttataaagatggctcttacattgatcatcaa
gacgttccatacactggtgcttatggcgttgtactcttagaggggatttctcaaatgatg
ccgatgataaaagaaacaccttttaatgataaaacccaaaatgatacaaccttaaagtca
tggattgacgacggatttatgccactcatttataaaggtgaaatgatggatttatcacga
ggtagagctatcagtcgtgaaaatgaaaccagtcactcagcatctgcaacagtaatgaaa
tcattgttgagattaagtgatgccatggatgattcaacaaaagctaagtataaaaagatt
gtcaaatcttcagtagagtcagattcaagttataaacaaaatgattatttaaattcatat
tcggacatagataaaatgaagtctttaatgacagataacagtatttctaaaaacggatta
acacaacaacttaaaatatataatgacatggatcgtgtcacctatcataacaaagactta
gactttgcatttggtttaagtatgacgtcgaaaaacgtagcacgctatgaaagtatcaac
ggagagaatttaaaaggttggcacactggtgctggaatgtcttatttatataacagcgat
gtcaaacactatcatgataacttctgggtgacagccgatatgaaacgtttatcaggtaca
acaactttagacaatgaaatattaaaagatacggatgataaaaagtcgagtaaaactttt
gttggcggaacaaaagttgatgaccaacatgctagtatcggaatggattttgaaaatcag
gacaaaactttaactgccaaaaaatcatatttcatattaaacgataaaattgtcttctta
ggaactggcattaaaagtactgattcatcaaagaatccagttacaacgattgaaaatcgc
aaagcgaatgggtatacgttatatacagacgataaacaaacaaccaattctgataatcag
gaaaacaattcagtctttttagagtccacagataccaaaaagaacatcggttatcatttt
ttaaacaaaccgaaaataactgtaaaaaaagaaagtcatactggtaagtggaaagaaata
aataaaagtcaaaaggatacacaaaaaactgatgagtattatgaagtaactcaaaagcat
tctaattctgacaataaatatggatatgtgttgtatccaggcttatctaaagatgtcttt
aagacaaaaaaagatgaagtaactgtcgttaagcaagaagatgacttccacgttgtgaaa
gataatgaatcggtttgggctggtgttaattatagtaatagcactcaaacttttgacatt
aacaacactaaagtcgaagttaaagccaaaggtatgtttatacttaaaaagaaagatgat
aacacttatgaatgtagcttctataatcctgaatctacaaattccgcttcagatattgaa
tctaaaatttcaatgaccggttactctattacaaacaaaaatacgtcgacttctaatgaa
tccggcgtgcactttgaattaactaaa
24.
gtgaatgatttgaagcaatttctatatattgcgttagtatgtggtgtgatagcaggtctt
ggtgctttcttacatataccgcagtatccgagcatgacaattccacgtatagtagctatt
ttaggaattatcagtgctatgttgacttttaaagacaagcaaatcagcgcctcattaaag
tttagcgcattgttaattaatgtgctgccattatgcggtacctttgtagcttcaaat
25.
gtgtctcgtgaaatgtcatatcattggtttaagaaaatgttactttcaacaagtatttta
attttaagtagtagtagtttagggcttgcaacgcacacagttgaagcaaaggataactta
aatggagaaaaaccaactactaatttgaatcataatataacttcaccatcagtaaatagt
gaaatgaataataatgagactgggacacctcacgaatcaaatcaaacgggtaatgaagga
acaggttcgaatagtcgtgatgctaatcctgattcgaataatgtgaagccagactcaaac
aaccaaaacccaagtacagattcaaaaccagacccaaataaccaaaacccaagtccgaat
cctaaaccagatccagataacccgaaaccaaaaccggatccaaaaccagacccagataaa
ccaaagccaaatccggatccaaaaccagatccagataacccgaaaccaaatccagatcca
aaaccagacccagataaaccaaagccaaatccggatccaaaaccagatccagataaacca
aagccaaatccgaatccaaaaccagaccctaataagccaaatcctaacccgtcaccagat
cccgatcaacctggggattccaatcattctggtggctcgaaaaatggggggacatggaac
ccaaatgcttcagatggatctaatcaaggtcaatggcaaccaaatgggaatcaaggaaac
tcacaaaatcctactggtaatgattttgtatcccaacgatttttagccttggcaaatggg
gcttacaagtataatccgtatattttaaatcaaattaataagttgggcaaagattatgga
gaagttactgatgaagacatttataatattattcgaaaacaaaatttcagcggaaatgca
tatttaaatggattacaacagcaatcgaattactttagattccaatatttcaatccattg
aaatcagaaaggtactatcgtaatttagatgaacaagtactcgcattaattactggtgaa
attggatcaatgccagatttgaaaaagcccgaagataagccggattcaaaacaacgctca
tttgaaccgcatgaaaaagacgattttacagtagttaaaaaacaagaagataataagaaa
agtgcgtcaactgcatatagtaaaagttggctagcaattgtatgttctatgatggtggta
ttttcaatcatgctattcttatttgtaaagcgaaataaaaagaaaaataaaaacgaatca
cagcgacga
26.
atgaaaaataaaaaacgtgttttaatagcgtcatcattatcatgtgcaattttattgtta
tcagcagcaacgactcaagcaaattcagctcataaagactctcaagaccaaaataagaaa
gaacatgttgataagtctcaacaaaaagacaaacgtaatgttactaataaagataaaaat
tcaacagcaccggatgatattgggaaaaacggtaaaatcacaaaacgaactgaaacagta
tatgatgagaaaacaaatatactccaaaatttacaattcgactttatcgatgatccaact
tatgacaagaatgtattacttgttaaaaaacaaggctcaattcattcaaatttaaagttt
gaatctcataaagaagaaaaaaattcaaattggttaaagtatccaagtgagtaccatgta
gattttcaagtaaaaagaaatcgtaaaactgaaatattagaccaattgccgaaaaataaa
atttcaactgcaaaagtagacagtacattttcatatagctcaggtggtaaattcgattca
acaaaaggtattggacgaacttcatcaaatagctactccaaaacgattagttataatcag
caaaattatgacacaattgccagcggtaaaaataataactggcatgtacactggtcagtt
attgcgaatgacttgaagtatggtggagaagtgaaaaatagaaatgatgaattattattc
tatagaaatacgagaattgctactgtagaaaaccctgaactaagctttgcttcaaaatat
agatacccagcattagtaagaagtggctttaatccagaatttttaacttatttatctaat
gaaaagtcaaatgagaaaacgcaatttgaagtaacatacacacgaaatcaagatattttg
aaaaacagacctggaatacattatgcacctccaattttagaaaaaaataaagatggtcaa
agattaattgtcacttatgaagttgattggaaaaataaaacagttaaagtcgttgataaa
tattctgatgacaataaaccttataaagaagga
27.
atgtatacacgtacagctacaacaagtgatagtcaaaaaaatattactcaaagcttacaa
tttaatttcttaactgaacctaattatgataaagaaacagtatttattaaagcaaaaggt
acaattggtagtggtttgagaattttagacccaaatggttattggaatagtacattaaga
tggcctggatcttattcagtttcaattcaaaatgttgatgacaacaacaatacaaatgtg
actgactttgcaccaaaaaatcaggatgaatcaagagaagttaaatatacgtatggttat
aaaacaggtggagatttttcgattaatcgtggaggcttaactggaaatattacaaaagag
agtaattattcagagacgattagttatcaacaaccatcatatcgtacattacttgatcaa
tctacgtcacataaaggtgtaggttggaaagtagaagcacatttgataaataatatggga
catgaccatacgagacaattaactaatgatagtgataatagaactaaaagtgaaattttt
tctttaacacgaaatggaaatttatgggcgaaagataatttcacacctaaagacaaaatg
cctgtaactgtgtctgaagggtttaatccagaatttttagctgttatgtcacatgataaa
aaagacaaaggtaaatcacaatttgttgttcattataaaagatcaatggatgagtttaaa
atagattggaatcgccatggtttctggggctattggtctggtgaaaaccatgtagataaa
aaagaagaaaaattatcagcattatatgaagttgattggaagacacataatgtgaagttt
gtaaaagtacttaatgataatgaaaagaaa
28.
gtggtgaaatttatgaattatccaaatggtaaaccatatcgtaaaaatagtgctatagac
ggagggaaaaagaccgctgcctttagtaatattgagtatggtggacgtggtatgtcactt
gaaaaagatatcgaacattcaaatacgttttatcttaaaagcgacattgcagttattcac
aaaaagcctacgccagtacaaatagttaatgtcaactatcctaagcggagtaaagctgtg
attaacgaagcttattttcgtacaccttcaacaactgattacaacggcgtttatcaaggt
tattatattgattttgaagcaaaggaaactaaaaacaagacgtcctttcctttaaataat
attcatgaccatcaagtcgaacatatgaaaaatgcatatcaacaaaaaggtattgtgttt
ttaatgattcgttttaaaacgctagatgaagtttatcttttaccctattcaaaattcgaa
gtattttggaagagatataaagataatattaaaragtctataacagttgatgaaatacga
aaaaatggttaccatattccttatcagtatcaaccaagattagactatctaaaagcagtt
gataagttgatattagatgaaagtgaggaccgcgta
29.
gtgaatacaacgaaagcagcattacatggtgatgtgaagttacaaaatgataaagatcat
gctaagcaaacggttagtcaattagcacatctaaacaatgcacaaaaacatatggaagat
acgttaattgatagtgaaacaactagaacagcagttaagcaagatttgactgaagcacaa
gcattagatcaacttatggatgcattacaacaaagtattgctgacaaagatgcaacacgt
gcgagcagtgcatatgtcaatgcagaaccgaataaaaaacaatcctatgatgaagcagtt
caaaatgctgagtctatcattgcaggattaaataatccaactatcaataaaggtaatgta
tcaagtgcgactcaagcagtaatatcatctaaaaatgcattagatggtgttgaacgatta
gctcaagataagcaaactgctggaaattctctaaatcatttagatcaattaacaccagct
caacaacaagcgctagaaaatcaaattaataatgcaacaactcgtggcgaagtagcacaa
aaattaactgaagcacaagcacttaaccaagcaatggaagctttacgtaatagcattcaa
gatcaacagcaaacggaagcgggtagcaagtttatcaatgaagataaaccacaaaaagat
gcttaccaagcagcagttcaaaatgcaaaagatttaattaatcaaactaacaatccaacg
cttgataaagcacaagttgaacaattgacacaagctgttaaccaagctaaagataaccta
cacggtgatcaaaaacttgcagacgataaacaacatgcggttactgatttaaatcaatta
aatggtttgaataatccgcaacgtcaagcacttgaaagccaaataaacaacgcagcaact
cgtggcgaagtagcacaaaaattagctgaagcaaaagcgcttgatcaagcaatgcaagca
ttacgtaatagtattcaagatcaacaacaaacagaatctggtagcaagtttatcaatgaa
gataaaccgcaaaaagatgcttaccaagcagcagttcaaaatgcaaaagatttaattaac
caaacaggtaatccaacactcgacaaatcacaagtagaacaattgacacaagcagtaaca
actgcaaaagataatctacatggtgatcaaaaacttgctcgtgatcaacaacaagcagta
acaactgtaaatgcattgccaaacttaaatcatgcacaacaacaagcattaactgatgct
ataaatgcagcgcctacaagaacagaggttgcacaacatgttcaaactgctactgaactt
gatcacgcgatggaaacattgaaaaataaagttgatcaagtgaatacagataaggctcaa
ccaaattacactgaagcgtcaactgataaaaaagaagcagtagatcaagcgttacaagct
gcagaaagcattacagatccaactaatggttcaaatgcgaataaagacgctgtagaccaa
gtattaactaagcttcaagaaaaagaaaatgagttaaatggtaatgagagagtcgctgaa
gctaaaacacaagcgaaacaaactattgaccaattaacacatttaaatgctgatcaaatt
gcaactgctaaacaaaacattgatcaagcgacgaaacttcaaccaattgctgaattagta
gatcaagcaacgcaattgaatcaatctatggatcaattacaacaagcagttaatgaacat
gctaacgttgagcaaactgtagattacacacaagcagattcagataaacaaaatgcttat
aaacaagctattgctgatgctgaaaatgtattgaaacaaaatgcgaataagcaacaagtg
gatcaagcacttcaaaatattttaaatgcaaaacaagcattaaatggtgatgaacgtgta
gcacttgctaaaacaaatggtaaacatgacatcgaccaattgaatgcattaaacaatgct
caacaagatggatttaaaggtcgcatcgatcaatcaaacgatttaaatcaaatccaacaa
attgtagatgaggctaaggcacttaatcgtgcaatggatcaattgtcacaagaaatcact
gacaatgaaggacgcacgaaaggtagcacgaactatgtcaatgcagatacacaagtcaaa
caagtatatgatgaaacggttgataaagcgaaacaagcacttgataaatcgactggtcaa
aacttaactgcaaaacaagttatcaaattaaatgatgcagtcactgcagctaagaaagca
ttaaatggtgaagaaagacttaataatcgtaaagctgaagcattacaaagattggatcaa
ttaacacatctaaacaatgctcaaagacaattagcaatccaacaaattaataatgctgaa
acgctaaataaagcatctcgagcaattaatagagcaactaaattagataatgcaatgggt
gcagtacaacaatatattgacgaacagcaccttggtgttatcagcagcacaaattacatc
aatgcagatgacaatttgaaagcaaattatgataatgcaattgcgaatgcagcacatgag
ttagataaagtgcaaggtaatgcaattgcaaaagctgaagcagagcaattgaaacaaaat
attatcgatgctcaaaatgcattaaatggagaccaaaaccttgcaaatgccaaagataaa
gcaaatgcgtttgttaattcgttaaatggattaaatcaacagcaacaagatcttgcacat
aaagcaattaacaatgccgatactgtatcagatgtaacagatattgttaataatcaaatt
gacttaaatgatgcaatggaaacattgaaacatttagttgacaatgaaattccaaatgca
gagcaaactgtcaattaccaaaacgctgacgataatgctaaaacaaacttcgatgatgcc
aaacgtctagcaaatacattgctaaatagtgataacacaaatgtgaatgatatcaatggc
gcaatccaagcagtcaatgatgcaatccataatcttaatggtgatcaacgactacaagat
gctaaagacaaggcaattcaatctattaatcaagctttagctaataagctaaaagaaatc
gaagcttcaaatgcgacggatcaagacaagcttattgcgaaaaataaagcagaagaattg
gcaaacagcatcatcaacaacattaataaagcaacaagtaatcaggctgtatctcaagtt
caaacagcaggcaaccacgcgattgaacaagtgcatgccaatgaaataccaaaagcaaaa
attgatgccaataaagacgttgataagcaagttcaagcattaattgacgaaattgatcga
aatccaaatctaacagataaggaaaaacaagcacttaaagatcgtattaatcaaatactt
caacaaggtcataacggcattaacaatgcgatgactaaagaagaaattgaacaagccaaa
gcacaacttgcgcaagcattacaagacatcaaagatttagtgaaagctaaagaagatgcg
aaacaagatgttgataaacaagttcaagctttaattgacgaaatcgatcaaaatccaaat
ctaacagataaggaaaaacaagcacttaaagatcgtattaatcaaatacttcaacaaggt
catarcgacattamcaatgcgatgacaaaagaagcaattgaacaagcaaaagaacgttta
gcgcaagcattgcaagacatcaaagatttagtgaaagctaaagaagatgcgaaaaatgat
attgataaacgtgtacaagctttaattgacgaaatcgatcaaaatccaaatctaacagat
aaggaaaaacaagcacttaaagatcgaattaatcaaatacttcaacaaggtcataacgac
attaacaatgcgctgactaaagaagaaattgagcaggcaaaagcacaacttgcacaagca
ttgcaagacatcaaagatttagtgaaagctaaagaagatgcgaaaaatgcaataaaagcc
ttagctaatgcgaagcgtgatcaaatcaattcaaatccagatttaacacctgagcaaaaa
gcaaaagcgctcaaagaaattgacgaagctgaaaaacgagcactacaaaacgttgagaat
gctcaaactatagatcaattaaatcgaggattaaacttaggtttagatgacattagaaat
acacatgtatgggaggttgatgaacaacctgctgtaaatgaaatttttgaagcaacacct
gagcaaatcctagttaatggtgaactcattgtacatcgtgatgacatcattacagaacaa
gatattcttgcacacataaacttaattgatcagctttcagcagaagtcatcgatacacca
tcaactgcaacgatttctgatagcttaacagcaaaagttgaagttacattgcttgatgga
tcaaaagtgattgttaatgttcctgtaaaagttgtagaaaaagaattgtcagtagtcaaa
caacaggcaattgaatcaatcgaaaatgcggcacaacaaaagattaatgaaatcaataat
agtgtgacattaacactggaacaaaaagaagctgcaattgcagaagttaataagcttaaa
caacaagcaattgatcatgttaacaatgcacctgatgttcattcagttgaagaaattcaa
caacaagaacaagcgcatattgaacaatttaatccagaacaatttacgattgaacaagca
aaatcaaatgcaattaaatcgattgaagatgcaattcaacatatgattgatgaaatcaaa
gctcgtactgatctaacagataaagagaagcaagaagctattgctaagttaaatcaatta
aaagaacaagcaattcaagcgattcaacgtgcgcaaagcatcgatgaaataagtgagcaa
ttggaacaatttaaagctcaaatgaaagcagctaatccaacagcaaaagaactagctaaa
cgcaagcaagaagctattagtagaattaaagacttttcaaatgaaaaaataaatagtatt
cgaaatagtgaaattggcacagctgatgaaaaacaagcagcaatgaatcaaattaacgaa
attgtgcttgaaacaattagagatattaataatgcgcatacattacagcaagttgaggct
gcattgaacaatggtattgctcgaatttcagcagtacaaattgtaacatctgatcgtgct
aaacaatcgtcaagtactggaaatgaatctaatagccatttaacaattggttatggaact
gcaaatcatccatttaacagttcgactattggacataaaaagaaacttgatgaagatgat
gacattgatccacttcatatgcgtcactttagtaataatttcggtaatgttattaaaaac
gctattggtgtggtgggtatctctggtttactagctagtttctggttcttcattgccaaa
cgtcgtcgtaaagaagatgaagaggaagaattagaaataagagataataataaagattca
ataaaagagactttagacgatacaaaacatttaccacttttatttgcgaaacgtcgcaga
aaagaagatgaagaagatgttactgttgaagaaaaagattcgctaaataatggcgagtca
ctcgataaagttaaacatacgccgttcttcttaccaaaacgtcgtcgtaaagaagatgaa
gaagatgtggaagttacaaatgaaaacacagatgaaaaagtgttgaaagataacgaacat
tcaccactcttattcgcaaaacgacgcaaagataaagaggaagatgttgaaacaacaact
agtattgaatctaaagatgaggacgttcctttattattggctaaaaagaaaaatcaaaaa
gataaccaatccaaagacaaaaagtcagcatcaaaaaatacttctaaaaaggtagcagct
aaaaagaagaaaaagaaagctaagaaaaataaaaaa
30.
atgaatcaggaagttaaaaacaaaatattttcaatcttaaaaattacgtttgctacagct
ttatttatttttgtagcaatcacattgtatcgggagttatctggtattaactttaaagat
acgttggttgaatttagtaagattaaccgtatgtccttagtgttactatttattggtggt
ggggcatcgcttgttattctatcaatgtatgatgtgattttatctagagctttaaaaatg
gatatatccttaggcaaagttttaagagtaagttatatcatcaatgcattgaatgcgatt
gtaggtttcggtggctttattggtgcaggcgttagagcaatggtttataaaaactatacg
catgataaaaagaaattagttcactttatatccttaatacttatttcaatgttgacaggt
ttaagcttattatcattgctaattgtattccatgttttcgatgcatctttaatcttagat
aagattacatgggtaagatgggtattatatgtagtgtcatttttcttaccattattcatt
atttattcaatggttagaccacccgataaaaacaatcgttttgtaggattgtactgcact
ttagtgtcgtgtgttgaatggttagcagctgcagttgtattatatttctgtggtgtaatt
gttgacgctcatgtatcattcatgtcctttattgcaatatttatcattgctgcattatca
ggtttagtcagctttattcctggtggtttcggcgctttcgatttagttgtattactagga
tttaaaactttaggtgtccctgaggaaaaagtattattaatgctacttctatatcgtttt
gcgtactattttgtaccggtaattattgcattaattttatcatcatttgaatttggtaca
tcagctaagaagtacattgagggatctaaatactttattcctgctaaagatgttacgtca
tttttaatgtcttatcaaaaggatattattgctaaaattccatcattatcattagcaatt
ttagtattctttacaagtatgatcttttttgtaaataacttaacgattgtttacgatgct
ttatatgatggaaatcacttaacgtattatattctattggcaattcatactagtgcttgt
ttattacttttactgaatgtagttggtatttataagcaaagtagacgtgccattatcttt
gctatgatttcaattttattaatcacagtggcgacattcttcacttacgcttcatatatt
ttaataacatggttagctattatttttgttctgcttattgtagctttccgtagagcacgt
aggttgaaacgcccagtaagaatgagaaatatagttgcaatgcttttattcagtttattt
attttatatgttaaccatatatttattgctggaacgttatatgcattagatatttatacg
attgaaatgcatacatctgtattgcgctattacttctggcttacgattttaatcatcgct
atcatcataggtatgattgcatggttgtttgattatcaatttagcaaagtacgtatttct
tctaaaattgaagattgcgaggagattattaatcagtacggcggtaattatttgagtcac
ttgatatatagtggtgacaagcagtttttcactaatgaaaataaaacagcatttttaatg
tatcgttataaagcaagttcattagtggttcttggagatccgttaggtgatgaaaatgcc
tttgatgaattgttagaagcattctataattacgctgagtatttaggctatgatgttata
ttctatcaagttacagatcaacacatgcctttatatcataatttcggtaaccaatttttc
aaattaggtgaagaagcaattattgatttaacgcaattttcaacttcaggtaaaaaacgc
cgtggatttagagcgactttaaataaattcgatgaacttaatatttcgttcgaaattatt
gaaccaccgttttcaactgaatttataaatgaacttcaacatgtaagtgatttatggcta
gataatcgtcaggaaatgcatttctctgttggtgaatttaatgaagaatacttatctaaa
gcgccaattggtgtaatgcgaaatgaagaaaatgaagtaattgcattttgtagtttaatg
ccaacatactttaatgatgccatttcagtcgatttaattagatggttgccagagttagat
ttaccattaatggatggtctatacttgcatatgttactttggagtaaagaacaaggttat
acaaaatttaatatgggtatggcaacgttatcgaacgttggtcaattgcattattcatat
ttaagagaacgacttgcaggccgtgtctttgaacatttcaacggtctatatcgtttccaa
ggattacgtcgttataaatctaaatataatccgaattgggaaccacgctttttagtttat
cgtaaagataattcgctttgggaatcactttctaaagtaatgcgtgtaatacgtcacaaa
31.
atggttgcattaacgcttgtaggttcagcagtcactgcacatcaagttcaagcagctgag
acgacacaagatcaaactactaataaaaacgttttagatagtaataaagttaaagcaact
actgaacaagcaaaagctgaggtaaaaaatccaacgcaaaacatttctggcactcaagta
tatcaagaccctgctattgtccaaccaaaaacagcaaataacaaaacaggcaatgctcaa
gtaagtcaaaaagttgatactgcacaagtaaatggtgacactcgtgctaatcaatcagcg
actacaaataatacgcagcctgttgcaaagtcaacaagcactacagcacctaaaactaac
actaatgttacaaatgctggttatagtttagttgatgatgaagatgataattcagaaaat
caaattaatccagaattaattaaatcagctgctaaacctgcagctcttgaaacgcaatat
aaaaccgcagcacctaaagctgcaactacatcagcacctaaagctaaaactgaagcgaca
cctaaagtaactacttttagcgcttcagcacaaccaagatcagttgctgcaacaccaaaa
acgagtttgccaaaatataaaccacaagtaaactcttcaattaacgattacattcgtaaa
aataacttaaaagcacctaaaattgaagaagattatacatcttacttccctaaatacgca
taccgtaacggcgtaggtcgtcctgaaggtatcgtagttcatgatacagctaatgatcgt
tcgacgataaatggtgaaattagttatatgaaaaataactatcaaaacgcattcgtacat
gcatttgttgatggggatcgtataatcgaaacagcaccaacggattacttatcttggggt
gtcggtgcagtcggtaaccctagattcatcaatgttgaaatcgtacacacacacgactat
gcttcatttgcacgttcaatgaataactatgctgactatgcagctacacaattacaatat
tatggtttaaaaccagacagtgctgagtatgatggaaatggtacagtatggactcactac
gctgtaagtaaatatttaggtggtactgaccatgccgatccacatggatatttaagaagt
cataattatagttatgatcaattatatgacttaattaatgaaaaatatttaataaaaatg
ggtaaagtggcgccatggggtacgcaatctacaactacccctactacaccatcaaaacca
acaacaccgtcgaaaccatcaactggtaaattaacagttgctgcaaacaatggtgtcgca
caaatcaaaccaacaaatagtggtttatatactactgtatacgacaaaactggtaaagca
actaatgaagttcaaaaaacatttgctgtatctaaaacagctacattaggtaatcaaaaa
ttctatcttgttcaagattacaattctggtaataaatttggttgggttaaagaaggcgat
gtggtttacaacacagctaaatcacctgtaaatgtaaatcaatcatattcaatcaaacct
ggtacgaaactttatacagtaccttggggtacatctaaacaagttgctggtagtgtgtct
ggctctggaaaccaaacatttaaggcttcaaagcaacaacaaattgataaatcaatttat
ttatatggctctgtgaatggtaaatctggttgggtaagtaaagcatatttagttgatact
gctaaacctacgcctacaccaacacctaagccatcaacacctacaacaaataataaatta
acagtttcatcattaaacggtgttgctcaaattaatgctaaaaacaatggcttattcact
acagtttatgacaaaactggtaagccaacgaaagaagttcaaaaaacatttgctgtaaca
aaagaagcaagtttaggtggaaacaaattctacttagttaaagattacaatagtccaact
ttaattggttgggttaaacaaggtgacgttatttataacaatgcaaaatcacctgtaaat
gtaatgcaaacatatacagtaaaaccaggcactaaattatattcagtaccttggggcact
tataaacaagaagctggtgcagtttctggtacaggtaaccaaacttttaaagcgactaag
caacaacaaattgataaatctatctatttatttggaactgtaaatggtaaatctggttgg
gtaagtaaagcatatttagctgtacctgctgcacctaaaaaagcagtagcacaaccaaaa
acagctgtaaaagcttatactgttactaaaccacaaacgactcaaacagttagcaagatt
gctcaagttaaaccaaacaacactggtattcgtgcttctgtttatgaaaaaacagcgaaa
aacggtgcgaaatatgcagaccgtacgttctatgtaacaaaagagcgtgctcatggtaat
gaaacgtatgtattattaaacaatacaagccataacatcccattaggttggttcaatgta
aaagacttaaatgttcaaaacttaggcaaagaagttaaaacgactcaaaaatatactgtt
aataaatcaaataacggcttatcaatggttccttggggtactaaaaaccaagtcatttta
acaggcaataacattgctcaaggtacatttaatgcaacgaaacaagtatctgtaggcaaa
gatgtttatttatacggtactattaataaccgcactggttgggtaaatgcaaaagattta
actgcaccaactgctgtgaaaccaactacatcagctgccaaagattataactacacttat
gtaattaaaaatggtaatggttattactatgtaacaccaaattctgatacagctaaatac
tcattaaaagcatttaatgaacaaccattcgcagttgttaaagaacaagtcattaatgga
caaacttggtactatggtaaattatctaacggtaaattagcatggattaaatcaactgat
ttagctaaagaattaattaagtataatcaaacaggtatggcattaaaccaagttgctcaa
atacaagctggtttacaatataaaccacaagtacaacgtgtaccaggtaagtggacaggt
gctaactttaatgatgttaagcatgcaatggatacgaagcgtttagctcaagatccagca
ttaaaatatcaattcttacgcttagaccaaccacaaaatatttctattgataaaattaat
caattcttaaaaggtaaaggtgtattagaaaaccaaggtgctgcatttaacaaagctgct
caaatgtatggcattaatgaagtttatcttatctcacatgccctattagaaacaggtaac
ggtacttctcaattagcgaaaggtgcagatgtagtgaacaacaaagttgtaactaactca
aacacgaaataccataacgtatttggtattgctgcatatgataacgatcctttacgtgaa
ggtattaaatatgctaaacaagctggttgggacacagtatcaaaagcaatcgttggtggt
gctaaattcatcggcaactcatatgtaaaagctggtcaaaatacactttacaaaatgaga
tggaatcctgcacatccaggaacacaccaatatgctacagatgtagattgggctaacatc
aatgctaaaatcatcaaaggctactatgataaaattggcgaagtcggcaaatacttcgac
atcccacaatataaa
32.
atgaaaggtaaatttttaaaagttagttctttattcgttgcaactttgacaacagcgaca
cttgtgagttctccagcagcaaacgcgttatcttcaaaggctatggacaatcatccacaa
caaacgcagtcaagcaaacagcaaacacctaagattcaaaaaggcggtaaccttaaacca
ttagaacaacgtgaacacgcaaatgttatattaccaaataacgatcgtcaccaaatcaca
gatacaacgaatggtcattatgcacccgtaacttatattcaagttgaagcacctactggt
acatttattgcttccggtgtagttgtaggtaaagatactcttttaacraataaacacgtc
gtagatgctacgcacggtgatcctcatgctttaaaagcattcccttctgcaattaaccaa
gacaattatccaaatggtggtttcactgctgaacaaatcactaaatattcagacgaaggt
gatttagcaatagttaaattctcccctaatgagcaacacaaacatattggtgaagtagtt
aaaccagcaacaatgagtaataatgctgacactcaagttaaccaaaatattactgtaaca
ggatatcctggtgataaacctgtagcaacaatgtgggaaagtaaaggaaaaatcacttac
ctcaaaggcgaagctatgcaatatgatttaagtacaactggtggtaattcaggttcacct
gtatttaatgaaaaaaatgaagtgatcggaattcattgggncggtgtaccaaatgaattt
aatggtgcggtatttattaatgaaaatgtacgcaacttcttaaaacaaaatattgaagat
atccattttgccacgatgaccaacctaataacccagataatcctgataaccctaacaatc
ctgataaccctaacaacccagatgaaccaaataaccctgacaaccctaacaaccctgata
atccagacaatggcgatamcaataattcagacaatccagatgcagcttaat
33.
gtgcaaaaaaaagtaattgcagctattattgggacaagcgcgattagcgctgttgcggca
actcaagcaaatgcggctacaactcacacagtaaaaccgggtgaatcagtgtgggcaatt
tcaaataagtatgggatttcgattgctaaattaaagtcattaaacaatttaacatctaat
ctaattttcccaaaccaagtactaaaagtatctggctcaagtaattctacgagtaatagt
agccgtccatcaacgaactcaggtggcggatcatactacacagtacaagcaggcgactca
ttatcattaatcgcatcaaaatatggtacaacttaccaaaacattatgcgacttaatggt
ttaaataatttctttatttatccaggtcaaaaattaaaagtatcaggtactgctagctca
agtaacgctgcgagcaatagtagccgtccatcaacgaactcaggtggcggatcatactat
acagtacaagcaggtgactcattgtcattaattgcatcaaaatatggtacaacttatcaa
aaaattatgagcttaaatggcttaaataatttctttatatatccgggtcaaaaattgaaa
gtaactggtaatgcatctacgaactcaggatctgcaacaacgacaaatagaggttacaat
acaccagtattcagtcaccaaaacttatatacatggggtcaatgtacatatcatgtattt
aatcgtcgtgctgaaattggtaaaggtattagtacttattggtggaatgctaataactgg
gataacgcagcggcagcagatggttacactatcgacaatagacctactgtaggttctatc
gctcaaacagatgtaggttactatggtcatgttatgtttgtagaacgtgtaaataacgat
ggtagtattttagtttcagaaatgaactattcagctgcaccaggtattttaacttacaga
acggtaccagcttaccaagtaaataattatagatatattcac
34.
atgaataataaaaagacagcaacaaatagaaaaggcatgataccaaatcgattaaacaaa
ttttcgataagaaagtattctgtaggtactgcttcaattttagtagggacaacattgatt
tttgggttaagtggtcatgaagctaaagcggcagaacatacgaatggagaattaaatcaa
tcaaaaaatgaaacgacagccccaagtgagaataaaacaactaaaaaagttgatagtcgt
caactaaaagacaatacgcaaactgcaactgcagatcagcctaaagtgacaatgagtgat
agtgcaacagttaaagaaactagtagtaacatgcaatcaccacaaaacgctacagctaat
caatctactacaaaaactagcaatgtaacaacaaatgataaatcatcaactacatatagt
aatgaaactgataaaagtaatttaacacaagcaaaagatgtttcaactacacctaaaaca
acgactattaaaccaagaactttaaatcgcatggcagtgaatactgttgcagctccacaa
caaggaacaaatgttaatgataaagtacatttttcaaatattgacattgcgattgataaa
ggacatgttaatcagactactggtaaaactgaattttgggcaacttcaagtgatgtttta
aaattaaaagcaaattacacaatcgatgattctgttaaagagggcgatacatttactttt
aaatatggtcaatatttccgtccaggatcagtaagattaccttcacaaactcaaaattta
tataatgcccaaggtaatattattgcaaaaggtatttatgatagtacaacaaacacaaca
acatatacttttacgaactatgtagatcaatatacaaatgttagaggtagctttgaacaa
gttgcatttgcgaaacgtaaaaatgcaacaactgataaaacagcttataaaatggaagta
actttaggtaatgatacatatagcgaagaaatcattgtcgattatggtaataaaaaagca
caaccgcttatttcaagtacaaactatattaacaatgaagatttatcgcgtaatatgact
gcatatgtaaatcaacctaaaaatacatatactaaacaaacgtttgttactaatttaact
ggatataaatttaatccaaatgcaaaaaacttcaaaatttacgaagtgacagatcaaaat
caatttgtggatagtttcacccctgatacttcaaaacttaaagatgttactgatcaattc
gatgttatttatagtaatgataataaaacagctacagtcgatttaatgaaaggccaaaca
agcagcaataaacaatacatcattcaacaagttgcttatccagataatagttcaacagat
aatggaaaaattgattatactttagacactgacaaaactaaatatagttggtcaaatagt
tattcaaatgtgaatggctcatcaactgctaatggcgaccaaaagaaatataatctaggt
gactatgtatgggaagatacaaataaagatggtaaacaagatgccaatgaaaaagggatt
aaaggtgtttatgtcattcttaaagatagtaacggtaaagaattagatcgtacgacaaca
gatgaaaatggtaaatatcagttcactggtttaagcaatggaacttatagtgtagagttt
tcaacaccagccggttatacaccgacaactgcaaatgtaggtacagatgatgctgtagat
tctgatggactaactacaacaggtgtcattaaagacgctgacaacatgacattagatagt
ggattctacaaaacaccaaaatatagtttaggtgattatgtttggtacgacagtaataaa
gatggtaaacaagattcgactgaaaaaggaattaaaggtgttaaagttactttgcaaaac
gaaaaaggcgaagtaattggtacaactgaaacagatgaaaatggtaaataccgctttgat
aatttagatagtggtaaatacaaagttatctttgaaaaacctgctggcttaactcaaaca
ggtacaaatacaactgaagatgataaagatgccgatggtggcgaagttgatgtaacaatt
acggatcatgatgatttcacacttgataatggctactacgaagaagaaacatcagatagc
gactcagattctgacagcgattcagactcagatagcgactcagattcagatagcgactca
gattcagacagcgattcagacagcgactcagactcagatagcgattcagattcagacagc
gactcagactcagacagcgattcagactcggatagcgactcagactcagatagcgactca
gattcggatagcgactcagactcagatagcgattcagattcagatagcgattcggactca
gacagtgattcagattcagactcagatagcgactcagattctgacagcgattcagactca
gacagcgactcagactcagacagtgattcagattcagacagcgactcagattcagatagc
gactcagactcagatagcgactcagactcagatagcgactcagactcggatagcgattca
gattcagacagcgactcagattcagatagcgattcggactcagacaacgactcagattca
gatagcgattcagattcagatgcaggtaaacatactccggctaaaccaatgagtacggtt
aaagatcagcataaaacagctaaagcattaccagaaacaggtagtgaaaataataattca
aataatggcacattattcggtggattattcgcggcattaggatcattattgttattcggt
cgtcgtaaaaaacaaaataaa
35.
atggacataaattcagaagaatacaaacaagaggtacttatcaaagacgttgtcatgctt
gctgctcgcatactattagaatctggtgcagaaggtacgcgtgtagaagataccatgaca
cgtattgcaaaaaaacttggttacagtgaaagtaacagctttgttacaaacactgtcatc
cagtttacgttacattcggaatcgtttcctagaatatttagaattacctctcgagataca
aacttaataaaaatttctcaagctaataaaatttcgcgtcaaattacaaacaatgaaatt
tctttagccgaagcaaaaacgcaacttgaaaaaatatatgttgctaagcgtgacagcagt
cttccctttaaaggttttgctgcagcaatgattgcaatgagtttcttatatttacaaggt
ggtagattgattgatgttttaactgcgatattagcaggtagtctaggatacctagtcact
gagattttagatcgtaagttacacgcacagtttatcccagaattcattggttcattagtt
attgggattatcgccgttattggacatacacttattccaacaggtgacttggcaactatt
atcattgcggcagtcatgcctattgttcctggtgtattaataacaaacgcaatacaagat
ttatttggtggacacatgttgatgttcacaacgaaatcattagaagcattggttactgcg
tttggcatcggtgctggcgttggtagcgtattaattttagta
36.
gtgattgctataatgaatgtaattatcgatgaaagaaaagagaatgctatgacatttaat
aaagtattattgagctggatagtcatattgattataacaactagcatatatctattttgg
cagttgggcgatatcaatgatgtatttaaccagtctattttaatcaatgttagattaccg
agattattagaagcattgttgacaggtatgatattaactgttgcaggccttatatttcaa
acagttttaaataatgcattggcagatagctttacattaggattggcaagcggcgctaca
tttggttcaggattagcattatttttaggtttaacaacgttatggattcctgtattttca
ataacatttagtttgataacattaataactgtattagtcattacgtcggtattgagccaa
ggctatccagttagaatcttaatattaagtggtttaatgattggtgcgttattcaattca
cttctatattttttgattttattaaaacctcgcaaattaaatacaattgccaattatctg
tttggtggttttggtgatgcagaatactcaaatgtatctataatagcaatcacatttatc
attgcattgtttggtatatttatcattcttaatcaactaaagttattgcaattaggagaa
ctaaaaagtcagtcactaggcttaaatgttcaattgattacatatatcgcgttatgtata
gcttctatgataacggcgataaatgtcgcatatgttggcatcattggattcattggtatg
gtgataccgcaactcattagaaaatggcagtggaaacaatcattaggaagacaattggct
ttaaatattgtaactggaggacaaataatggttatggcagattttattggtagccatata
ttgtcaccagtacaaataccggcaagtattatcattgcattaattggtataccagtgtta
ttttacatgctaatatctcagtcgaaacggttacac
37.
ttgaaaaaattagcatttgcaataacagcaacatctggtgcagctgcatttttaacgcat
catgatgcacaagcttctacacaacatacagtacaatctggtgaatcattatggagtatt
gctcaaaaatacaacacttcagtagagagtattaaacaaaataaccaattagataacaac
ttggtattccctggtcaagttatctcagtaggtggaagtgatgcacaaaatacgtcaaac
acttctccacaagctggttcagcatcatctcatactgtacaagctggtgaatcattaaat
atcattgctagcagatatggtgtttcagttgatcaattaatggcagccaataacttacgt
ggttatttaattatgcctaaccaaacattacaaattcctaatggtggatcaggtggtaca
acaccaacagctacaacaggtagcaatggcaatgcatcatcttttaatcaccaaaattta
tacactgctggtcaatgtacatggtacgtatttgaccgtcgtgctcaagctggtagtcca
attagcacatattggtcagacgctaagtattgggctggtaacgcagctaatgatggttac
caagtaaacaacacaccatcagttggttcaattatgcaaagcacacctggtccatatggt
catgttgcttatgttgaacgtgtcaatggtgatggtagtatcttgatttctgaaatgaat
tacacatatggtccatacaatatgaactaccgtacaattccagcttcagaagtttctagc
tatgcattcatccat
38.
atgccagattcaatcacaattatagatgaaaacaaagtgattgatgttgtattaattgca
ggtagaattttacttgaatcaggtgctgaaacatatcgagttgaagatacaatgaaccgt
atcgcacatagttatggtcttcataatacatatagttttgtcagttcaactgcaattatt
ttttcattaaacgatcgaacaagtacaagattaattcgtgtacaagagcgtacaacagat
ttagagaaaatcgctttaacgaatagtctttcacgtaaaatatcaaataaagaactcaca
attgatgaagctaaatctgaatttattcatttacagcatgcatcattacaatattctttt
ttaacgaatttctttgcagctgccattgcatgtggcttcttcctatttatgtttggtggt
gtcgcatcagattgttggattgcagtcattgctggcggatccgcatttttaacattcagc
tttgtgcaacgctatatacaaattaaatttttctcagagtttgttgcagccgctgtggtc
atatccattgcagccacatttactaaattaggcattgcaaccaatcaagatatcattact
atagccagtgtcatgccacttgtccctggtatattaattaccaatgccattcgagattta
ttagcgggtgaattacttgcaggtatgtctcgcggtgttgaagctgcattaacagcattc
gcaatcggtgctggtgtcgcaatcgttttattaatcatt
39.
atgggatttttatcaaaaattcttgatggcaataataaagaaattaaacagttaggtaaa
cttgctgataaagtaatcgctttagaagaaaaaacggcaattttaactgatgaagaaatt
cgtaataaaacgaaacaattccaaacagaattagctgacattgataatgtcaaaaagcaa
aatgattatttagataaaattttaccagaagcatatgcacttgttagagaaggctctaaa
cgtgtattcaatatgacaccatataaagttcaaattatgggtggtattgcaattcataaa
ggtgatatcgctgagatgagaacaggtgaaggtaaaacattaacagcgacaatgccaaca
tacttaaatgcattagctggtagaggtgttcacgttattacagtcaatgaatacttatca
agtgttcaaagtgaagaaatggctgagttatataacttcttaggtttgactgtcggatta
aacttaaacagtaagacgacagaagaaaaacgtgaagcatacgcacaagacattacttac
agtactaataatgagctaggttttgattacttacgagataacatggtgaattattctgaa
gatagagtaatgcgtccattacattttgcaatcattgatgaggttgactcaattttaatc
gacgaggcacgtacgccattaattatttctggtgaagctgaaaagtcaacgtcactttat
acacaagcaaatgtttttgcgaaaatgttaaaacaggacgaagattataaatacgatgaa
aaaacgaaagctgtacatttaacagaacaaggtgcggataaagctgaacgtatgttcaaa
gttgaaaacttatatgatgtacaaaatgttgatgttattagtcatatcaacacagcttta
cgtgcgcacgttacattacaacgtgacgtagactatatggttgttgatggcgaagtatta
attgtcgatcaatttacaggacgtacaatgccaggccgtcgtttctcggaaggtttacac
caagctattgaagcgaaggaaggcgttcaaattcaaaatgaatctaaaactatggcgtct
attacattccaaaactatttcagaatgtacaataaacttgcgggtatgacaggtacagct
aaaactgaagaagaagaatttagaaatatttataacatgacagtaactcaaattccgaca
aataaacctgtgcaacgtaacgataagtctgatttaatttacattagccaaaaaggtaaa
tttgatgcagtagtagaagatgttgttgaaaaacacaaggcagggcaaccagtgctatta
ggtactgttgcagttgagacttctgaatatatttcaaatttacttaaaaaacgtggtatc
cgtcatgatgtgttaaatgcgaaaaatcatgaacgtgaagctgaaattgttgcaggcgct
ggacaaaaaggtgccgttactattgccactaacatggctggtcgtggtacagatatcaaa
ttaggtgaaggcgtagaggaattaggcggtttagcagtaataggtacagagcgacatgaa
tctcgtcgtattgatgaccagttacgtggtcgttctggacgtcaaggtgataaaggggat
agtcgcttctatttatcattacaagatgaattaatgattcgttttggttctgaacgttta
cagaaaatgatgagccgactaggtttagatgactctacaccaattgaatcaaaaatggta
tcaagagctgtagaatcagcacaaaaacgtgtagaaggtaataacttcgacgcgcgtaaa
cgtatcttagaatacgatgaagtattacgtaaacaacgtgaaattatctataacgaaaga
aatagtattattgatgaagaagacagctctcaagttgtagatgcaatgctacgttcaacg
ttacaacgtagtatcaattactatattaatacagcagatgacgagcctgaatatcaacca
ttcatcgactacattaatgacatcttcttacaagaaggtgacattacagaggatgatatc
aaaggtaaagatgctgaagatattttcgaagtcgtttgggctaagattgaagcagcatat
caaagtcaaaaagatatcttagaagaacaaatgaatgagtttgagcgtatgattttactt
cgttctattgatagccattggactgatcatatcgacacaatggatcaattacgtcaaggt
attcacttacgttcttatgcacaacaaaatccattacgtgactatcaaaatgaaggtcat
gaattatttgatatcatgatgcaaaatattgaagaagatacttgtaaattcattttaaaa
tctgtagtacaagttgaagataatattgaacgtgaaaaaacaacagagtttggtgaagcg
aagcacgtttcagctgaagatggtaaagaaaaagtgaaaccgaaaccaatcgttaaaggc
gatcaagttggtcgtaacgatgattgtccatgtggtagtggtaaaaaattcaaaaattgc
catggaaaa
40.
gtgagggagagtatgtcgaatcaaaattacgactacaataaaaatgaagatggaagtaag
aagaaaatgagtacaacagcgaaagtagttagcattgcgacggtattgctattactcgga
ggattagtatttgcaatttttgcatatgtagatcattcgaataaagctaaagaacgtatg
ttgaacgaacaaaagcaggaacaaaaagaaaagcgtcaaaaagaaaatgcagaaaaagag
agaaagaaaaagcaacaagaggaaaaagagcagaatgagctagattcacaagcaaaccaa
tatcagcaattgccacagcagaatcaatatcaatatgtgccacctcagcaacaagcacct
acaaagcaacgtcctgctaaagaagagaatgatgataaagcatcaaaggatgagtcgaaa
gataaggatgacaaagcatctcaagataaatcagatgataatcagaagaaaactgatgat
aataaacaaccagctcagcctaaaccacagccgcaacaaccaacaccaaagccaaataat
aatcaacaaaacaatcaatcaaatcagcaagcaaaaccacaagcaccacaacaaaatagc
caatcaacaacaaataaacaaaataatgctaatgataag
41.
atgaatatgaagaaaaaagaaaaacacgcaattcggaaaaaatcgattggcgtggcttca
gtgcttgtaggtacgttaatcggttttggactactcagcagtaaagaagcagatgcaagt
gaaaatagtgttacgcaatctgatagcgcaagtaacgaaagcaaaagtaatgattcaagt
agcgttagtgctgcacctaaaacagacgacacaaacgtgagtgatactaaaacatcgtca
aacactaataatggcgaaacgagtgtggcgcaaaatccagcacaacaggaaacgacacaa
tcatcatcaacaaatgcaactacggaagaaacgccggtaactggtgaagctactactacg
acaacgaatcaagctaatacaccggcaacaactcaatcaagcaatacaaatgcggaggaa
ttagtgaatcaaacaagtaatgaaacgacttctaatgatactaatacagtatcatctgta
aattcacctcaaaattctacaaatgcggaaaatgtttcaacaacgcaagatacttcaact
gaagcaacaccttcaaacaatgaatcagctccacagagtacagatgcaagtaataaagat
gtagttaatcaagcggttaatacaagtgcgcctagaatgagagcatttagtttagcggca
gtagctgcagatgcaccggcagctggcacagatattacgaatcagttgacgaatgtgaca
gttggtattgactctggtacgactgtgtatccgcaccaagcaggttatgtcaaactgaat
tatggtttttcagtgcctaattctgctgttaaaggtgacacattcaaaataactgtacct
aaagaattaaacttaaatggtgtaacttcaactgctaaagtgccaccaattatggctgga
gatcaagtattggcaaatggtgtaatcgatagtgatggtaatgttatttatacatttaca
gactatgtaaatactaaagatgatgtaaaagcaactttgaccatgcccgcttatattgac
cctgaaaatgttaaaaagacaggtaatgtgacattggctactggcataggtagtacaaca
gcaaacaaaacagtattagtagattatgaaaaatatggtaagttttataacttatctatt
aaaggtacaattgaccaaatcgataaaacaaataatacgtatcgtcagacaatttatgtc
aatccaagtggagataacgttattgcgccggttttaacaggtaatttaaaaccaaatacg
gatagtaatgcattaatagatcagcaaaatacaagtattaaagtatataaagtagataat
gcagctgatttatctgaaagttactttgtgaatccagaaaactttgaggatgtcactaat
agtgtgaatattacattcccaaatccaaatcaatataaagtagagtttaatacgcctgat
gatcaaattacaacaccgtatatagtagttgttaatggtcatattgatccgaatagcaaa
ggtgatttagctttacgttcaactttatatgggtataactcgaatataatttggcgctct
atgtcatgggacaacgaagtagcatttaataacggatcaggttctggtgacggtatcgat
aaaccagttgttcctgaacaacctgatgagcctggtgaaattgaaccaattccagaggat
tcagattctgacccaggttcagattctggcagcgattctaattcagatagcggttcagat
tcgggtagtgattctacatcagatagtggttcagattcagcgagtgattcagattcagca
agtgattcagactcagcgagtgattcagattcagcaagcgattccgactcagcgagcgat
tccgactcagacaatgactcggattcagatagcgattctgactcagacagtgactcagat
tccgacagtgactcagattcagatagcgattctgactcagacagtgactcagattcagat
agcgattcagattcagatagcgattcagattccgacagtgattccgactcagacagcgat
tctgactccgacagtgattccgactcagacagcgattcagattccgacagtgattccgac
tcagatagcgattccgactcagatagcgactcagattcagacagcgattcagattcagac
agcgattcagattcagatagcgattcagattccgacagtgactcagattccgacagtgac
tcggattcagatagcgattcagattccgacagtgactcagattccgacagtgactcagac
tcagacagtgattcggattcagcgagtgattcggattcagatagtgattccgactccgac
agtgactcggattcagatagcgactcagactcggatagcgactcggattcagatagcgat
tcggactcagatagcgattcagaatcagacagcgattcagaatcagacagcgattcagat
tcagacagcgactcagacagtgactcagattcagatagtgactcggattcagcgagtgat
tcagactcaggtagtgactccgattcatcaagtgattccgactcagaaagtgattcaaat
agcgattccgagtcaggttctaacaataatgtagttccgcctaattcacctaaaaatggt
actaatgcttctaataaaaatgaggctaaagatagtaaagaaccattaccagatacaggt
tctgaagatgaagcaaatacgtcactaatttggggattattagcatcaataggttcatta
ctacttttcagaagaaaaaaagaaaataaagataagaaa
42.
atgaattcaaatcacgctaaagcatcagtgacagagagtgttgacaaaaaatttgtagtt
ccagaatcaggaattaataaaattattccagcttacgatgaatttaagaattcgccaaaa
gtaaatgttagtaatttaactgacaataaaaactttgtagcttctgaagataaattgaat
aagattgcagattcatcggcagctagtaaaattgtagataaaaactttgtcgtaccagaa
tcaaagttaggaaacattgtgccagagtacaaagaaatcaataatcgcgtgaatgtagca
acaaacaatccagcttcacaacaagttgataagcattttgttgctaaaggcccagaagta
aatagatttattacgcaaaacaaagtaaaccaccacttcattactacgcaaacccactac
aagaaagttattacttcatacaaatcaacacatgtacataaacatgtaaatcatgcaaag
gattctattaataaacactttattgttaaaccatcagaatcgcctagatatacacatcca
tctcaatctttaattatcaagcatcattttgcagttcctggatatcacgcgcataaattt
gttacaccagggcatgctagcattaaaattaatcacttttgtgttgtgccacaaataaat
agtttcaaggtaattccaccatatggtcacaattcacatcgtatgcatgtaccaagtttc
caaaataacacaacagcaacacatcaaaatgctaaagtaaataaagcatatgactataaa
tacttctattcttataaagtagttaaaggtgtgaagaaatatttctcattttcacaatca
aatggttataaaattgggaaaccatcattaaatatcaaaaatgtaaattatcaatatgct
gttccaagttatagccctacacactacgttcctgaatttaagggtagcttaccagcacca
cgagta
43.
ttggagcatacaattatgaaaatgagaacaattgctaaaaccagtttagcactagggctt
ttaacaacaggcgcaattacagtaacgacgcaatcggtcaaagcagaaaaaatacaatca
actaaagttgacaaagtaccaacgcttaaagcagagcgattagcaatgataaacataaca
gcaggtgcaaattcagcgacaacacaagcagctaacacaagacaagaacgcacgcctaaa
ctcgaaaaggcaccaaatactaatgaggaaaaaacctcagcttccaaaatagaaaaaata
tcacaacctaaacaagaagagcagaaaacgcttaatatatcagcaacgccagcgcctaaa
caagaacaatcacaaacgacaaccgaatccacaacgccgaaaactaaagtgacaacacct
ccatcaacaaacacgccacaaccaatgcaatctactaaatcagacacaccacaatctcca
accataaaacaagcacaaacagatatgactcctaaatatgaagatttaagagcgtattat
acaaaaccgagttttgaatttgaaaagcagtttggatttatgctcaaaccatggacgacg
gttaggtttatgaatgttattccaaataggttcatctataaaatagctttagttggaaaa
gatgagaaaaaatataaagatggaccttacgataatatcgatgtatttatcgttttagaa
gacaataaatatcaattgaaaaaatattctgtcggtggcatcacgaagactaatagtaaa
aaagttaatcacaaagtagaattaagcattactaaaaaagataatcaaggtatgatttca
cgcgatgtttcagaatacatgattactaaggaagagatttccttgaaagagcttgatttt
aaattgagaaaacaacttattgaaaaacataatctttacggtaacatgggttcaggaaca
atcgttattaaaatgaaaaacggtgggaaatatacgtttgaattacacaaaaaactgcaa
gagcatcgtatggcaggcactaatattgataacattgaagtgaatataaaa
44.
atgacaacaattaaaacatcaaacttaggattcccaagattaggtagaaaaagagaatgg
aaaaaagccatcgaaagttattgggcaaagaagatttctaaagaagaattagatcaaaca
ttaactgatctacataaagaaaatttattattacaaaagtactatcacttagatagcatc
ccagttggtgatttctctttatatgaccatatattagatacgtcattattattcaacatc
atccctgaacgtttccaaggaagaactattgatgatgatttattatttgatattgctcgc
ggtaataaagaccatgttgcaagtgcacttataaaatggtttaacactaactatcattac
atcgtacctgaatgggacaatgttgagcctaaagtgagtcgcaatgtattattagatcgc
tttaaatatgcccaatctttaaacgttaacgctcaccctgtcattgttggtccgattact
tttgttaaattatcaaaaggcggtcaccaaacttttgaagaaaaagttaaaacgttatta
ccactttataaagaagtgtttgaatcattaattgatgcaggtgctgagtacattcaagtt
gatgagccaatcttagttacagacgacagcgaaagctatgaaaatattacacgtgaagct
tatgactatttcgaaaaagctggtgttgctaaaaaattagtcattcaaacatactttgaa
cgtgcacatcttaaattcttaagttctttacctgttggtggtataggtttagactttgtc
catgataatggctataaccttaaacaaattgaagctggagattttgataaatcaaaaaca
ttatacgctggaattattgatggtcgtaatgtatgggcaagtgacattgaagctaaaaaa
gtcttaatcgataaattgttagcacacactaatgaacttgtcattcaaccatcatcttca
ttattacatgttccagtatctttagatgatgaaacattagatacaagtgttggagaaggc
ttaagctttgcaactgaaaaattagacgaattagatgcattgcgtcgcctatttaatcaa
aacgatagtgttaaatatgataaattaaaagcacgttatgagcgtttccaaaatcaatca
ttcaaaaacttagattatgatttcgaaagcgtgcgtacttcaagacaatcaccattcgcg
caacgtattgaacaacaacaaaaacgtttgaacttaccggatttaccaacaacaactatt
ggatcattcccacaaagccgagaagttcgaaaataccgtgcagattggaagaacaaacgc
attacagacgaagcatatgaaacattcttaaaaaatgaaattgctcgatggattaaaatt
caagaagacattggcttagatgtattagttcacggtgaatttgaacgtaatgacatggtt
gaattcttcggagaaaaattacaaggtttcttagtaactaaattcggttgggtgcaatca
tatggttcacgtgccgtaaaaccaccaatcatttatggtgatgtaaaatggacagcgcct
ttaactgttgatgaaacagtttatgcacaaagcttaacagataaaccagttaaaggtatg
ttaactggacctgtaacaattctaaactggtcatttgaacgtgttgatttaccacgtaaa
gtcgttcaagatcaaattgctttagcaatcaacgaagaagtattagcacttgaagctgca
ggaatcaaagttatccaagttgacgaacctgcattacgtgaaggcttaccattacgctct
gaatatcacgaacaatatcttaaagatgctgttttatcatttaaacttgcaacgtcttca
gttcgtgatgaaactcaaatccatacacatatgtgttattctcaattcggtcaaatcatt
catgctattcatgacttagatgctgatgttatttcaattgaaacatctcgtagccatggt
gatttaattaaagactttgaagatattaattatgatttaggtattggtctaggtgtatat
gatattcatagtccacgtattccaacaaaagaagaaattactacagcaatcaatcgttca
ctacaacaaatcgaccgctcattattctgggtaaaccctgactgtggtttaaaaacgcga
aaagaagaagaagttaaagatgcattgactgtgcttgtgaatgctgttaaagctaaacgc
caagaa
45.
atgagcgacacatataaaagctacctagtagcagtactatgcttcacagtcttagcaatt
gtacttatgccgtttctatacttcactacagcatggtcaattgcgggattcgcaagtatc
gcaacattcatattttataaagaatacttttatgaagaa
46.
atgttaagaggacaagaagaaagaaagtatagtattagaaagtattcaataggcgtggtg
tcagtgttagcggctacaatgtttgttgtgtcatcacatgaagcacaagcctcggaaaaa
acatcaactaatgcagcggcacaaaaagaaacactaaatcaaccgggagaacaagggaat
gcgataacgtcacatcaaatgcagtcaggaaagcaattagacgatatgcataaagagaat
ggtaaaagtggaacagtgacagaaggtaaagatacgcttcaatcatcgaagcatcaatca
acacaaaatagtaaaacaatcagaacgcaaaatgataatcaagtaaagcaagattctgaa
cgacaaggttctaaacagtcacaccaaaataatgcgactaataatactgaacgtcaaaat
gatcaggttcaaaatacccatcatgctgaacgtaatggatcacaatcgacaacgtcacaa
tcgaatgatgttgataaatcacaaccatccattccggcacaaaaggtaatacccaatcat
gataaagcagcaccaacttcaactacacccccgtctaatgataaaactgcacctaaatca
acaaaagcacaagatgcaaccacggacaaacatccaaatcaacaagatacacatcaacct
gcgcatcaaatcatagatgcaaagcaagatgatactgttcgccaaagtgaacagaaacca
caagttggcgatttaagtaaacatatcgatggtcaaaattccccagagaaaccgacagat
aaaaatactgataataaacaactaatcaaagatgcgcttcaagcgcctaaaacacgttcg
actacaaatgcagcagcagatgctaaaaaggttcgaccacttaaagcgaatcaagtacaa
ccacttaacaaatatccagttgtttttgtacatggatttttaggattagtaggcgataat
gcacctgctttatatccaaattattggggtggaaataaatttaaagttatcgaagaattg
agaaagcaaggctataatgtacatcaagcaagtgtaagtgcatttggtagtaactatgat
cgcgctgtagaactttattattacattaaaggtggtcgcgtagattatggcgcagcacat
gcagctaaatacggacatgagcgctatggtaagacttataaaggaatcatgcctaattgg
gaacctggtaaaaaggtacatcttgtagggcatagtatgggtggtcaaacaattcgttta
atggaagagtttttaagaaatggtaacaaagaagaaattgcctatcataaagcgcatggt
ggagaaatatcaccattattcactggtggtcataacaatatggttgcatcaatcacaaca
ttagcaacaccacataatggttcacaagcagctgataagtttggaaatacagaagctgtt
agaaaaatcatgttcgctttaaatcgatttatgggtaacaagtattcgaatatcgattta
ggattaacgcaatggggctttaaacaattaccaaatgagagttacattgactatataaaa
cgcgttagtaaaagcaaaatttggacatcagacgacaatgctgcctatgatttaacgtta
gatggctctgcaaaattgaacaacatgacaagtatgaatcctaatattacgtatacgact
tatacaggtgtatcatctcatactggtccattaggttatgaaaatcctgatttaggtaca
tttttcttaatggctacaacgagtagaattattggtcatgatgcaagagaagaatggcgt
aaaaatgatggtgtcgtaccagtgatttcgtcattacatccgtccaatcaaccatttgtt
aatgttacgaatgatgaacctgccacacgcagaggtatctggcaagttaaaccaatcata
caaggatgggat
47.
atgattcatctcattaaggggaagatgcatcatacagttttgtgtattcatttaaacaaa
ggggttgctttaatgaatcaatatcattctaatgcacaacaaccaagtgcatggcgtttt
tttgtctatagtttagtgggcatactatgtttctttattccttttacgattaatggtaac
aacactattttcgtcgatcatgttcatctagccattcgctcaatcataggtccacttatg
ccctatgttgcactgattatgattttaattggtacagcgttaccaatagtgagacgtact
tttatgacttcaatcacaaacttggtcattacattatttaaagttgcaggtgcaatgatc
ggtataatgtatgtatttaaaatcggtccatcaatactatttaaagctaactatggtccg
tttttgtttgaaaaattaatgatgccattaagtatcttaattccagtaggtgcaattgcg
ctttctttattagtgggctatggcttattagaatttgtcggtgtttatatggagcctatt
atgagacctatttttaaaacaccaggaaaatccgctgtcgatgcagtggcttcgtttgtc
ggcagttattccttaggattattgattactaatcgtgtctataagcaagggatgtacaac
aaacgagaagccacgattattgcgactggcttttcaacagtttcagcaacttttatgatt
atcgttgctaaaactttaggattaatgccgcattggaatttatacttttggataacttta
gtcatcacatttgtcgtgactgcaattactgcatggctaccgccaatcagcaatgaatca
acagaatattataacggacaagaaggagaacaagaagttgctattgaaggaagcagactg
aaaactgcatatgcagaggcgatgaaacaaaatgcattaacaccatctctcgtgaagaac
gtttgggacaatttgaaagacggtttagaaatgactgttggtattttaccttctatatta
tcgattggttttttaggactgattgtagcgaactatacaccattcattgattggcttggc
tatatcttctatccatttatttatattttcccaattgctgatcaggctttactagcaaaa
gcgtcagcgatttctattgtagagatgtttctaccatctttgttagtaactaaagctgca
atgagtactaaatttgtcgtcggtgtagtaagcgtatcagccattatctttttctcagca
ttagtgccatgtatactagcaactgaaattaaaatacctgtctggaaactcatcatcatt
tggtttttacgcgtggcgttgtcgctattaatcaccatccccgtcgctttacttattttt
gga
48.
atggttattatgaagaaaacaattttactgacgatgacaactcttactttatttagtatg
tcgcctaactcggctcaagcatatacgaatgatagcaaaacattagaagaagcaaagaaa
gcacacccaaacgcacagttcaaagtgaataaagacaccggcgcgtatacttatacatat
gacaaaaacaacacgccaaacaacaatcatcaaaaccagtcacgtacaaacgacaatcat
caacacgcaaatcaacgtgatcttaacaacaatcagtaccattcttcattaagtggtcag
tatacgcacattaatgacgcaattgattcacacacaccgcctcaaacgtcaccaagcaat
cctttgacaccagcaataccgaatgtcgaagacaatgacgatgaattaaataacgctttt
tcaaaagataacaaagggcttattacaggcatcgatttagacgaattgtatgacgaatta
caaatcgccgaatttaatgacaaagcaaagaccgctgacggtaaacctttagcattaggt
aacggtaaaatcattgatcagcctcttatcacaagtaagaacaacttatatactgctgga
caatgtacatggtatgtctttgataaacgtgccaaagatggacacacgattagtacattt
tggggagatgctaaaaactgggcaggccaagcttcaagcaatggcttcaaagtagataga
cacccaacacgaggatcaattttacaaacagtaaatggtccatttggtcatgtagcctac
gttgaaaaagttaatattgatggaagtattctaatttcagaaatgaactggattggtgaa
tatatcgtttcatcaagaaccatctctgcttcagaagtttcatcatataattacatccat
49.
ttggaggtatcgtcaatgaagccttatatacaacttgttgtgttcaagcaatggttacaa
tacatcttgctcgtaacaaccattgtcatcgcactcgtacttattggtatcggttaccgt
gtagcacatgacaacttcaaaataccgattaccattcaagatttagaccaaaccactgca
tcaaaatcattcgtcaataaaattaaacaatctgactatgtaactattaaaaaagtcgat
gaagatgaaagctatattgaagatgatgttactaaaaaggaagctattttaagtatgcaa
attcctaaaggtttctctcaaaaattaaaagagaaccgtttaaaagaaacgatacagtta
tatggtagagatgactttataggtggtattgctgtagaaattgttagtagttcattatat
gagcagcaaattcctaacattatttatgaacaccttgaggatatgaaacagcatcaatcc
atcgatgctatcaacaagtcctatcataaacatacacctgaatctaaaatcaaatttgtg
tcgcttactaaacaagcacaacactctatttcaattagcttaatctttgcggtgatttta
tttgttagcgctgttcaagtagtacttcattatcgtttaaaccaacaagcagcattgcaa
cgattatcacaatatcatttaagccgtttcaaactatatagtacttatgtaatgacacat
acgattttgttattgttggtactattggcagttagtctatatttgtctcaaccactcagc
ttaatattttacttaaaatcactgttacttatattgatttatgagataggtatcgtcttt
atcttattccatattcaaacaataagtcatcgattattcatgacatttatatatgcactt
gctatgggtatcgtatacttgattattttcatg
50.
atgattgaggtgacagagatgaacttttttgatatccataagattccgaacaaaggcatt
ccattatcggtacaacgtaaattatggcttagaaacttcatgcaagctttcttcgtagtg
ttctttgtttatatggctatgtatttaattcgaaacaactttaaggcggcacaaccgttt
ttaaaagaggaaattggattatctacattagaacttggttatatcggattagcatttagt
atcacgtacggtttaggaaaaacattacttggatattttgtcgatggacgtaacacaaaa
cgtattatctcgttcttacttatcttatctgcgattacagttttaattatgggatttgtt
ttaagttactttggttctgtaatgggattattaattgtactttggggacttaacggggtg
ttccaatcagttggtggacctgcaagttattcaacgatttcaagatgggcgccaagaacg
aaacgtggccgatacttaggattctggaatacatcacataatatcggtggtgccatagca
ggtggtgttgcactttggggtgctaatgtattcttccatggaaatgttatagggatgttc
attttcccatcggtgattgcattacttattggtatcgcaacattatttatcggaaaagat
gatccggaagaattaggatggaatcgtgctgaagaaatttgggaagagccggtcgataaa
gaaaatattgattctcaaggtatgacgaaatgggagatctttaaaaaatatatcctggga
aatcctgttatatggattctatgtgtttcaaacgtctttgtatacattgtacgaatcggt
attgataactgggcaccgttatatgtgtcagagcatttacactttagtaaaggcgatgca
gttaatacgatattctactttgaaattggtgcattagttgcaagtttattatggggctac
gtatcagacttattaaaaggtcgtcgtgcaattgtagctattggctgtatgtttatgatt
acatttgttgtcttattctacacaaatgctacaagtgtcatgatggttaacatttcattg
tttgcattaggtgcgttaatctttggtccgcaattattaattggtgtatcattgactggt
tttgttcctaaaaatgccatcagtgtagcaaacggaatgacaggttcattcgcgtatcta
ttcggtgactcaatggcgaaagttggtttggcggctattgctgatccaacacgtaacggt
ttaaacatctttggatatacattaagtggatggacagatgttttcatcgtcttctatgtt
gcattattcctaggcatgattctattaggaatcgttgctttctatgaagaaaagaaaatt
agaagtttaaaaatt
51.
atgacaaagaagaaaaacatattaaaagcaatcggtatttacagttttatagcgatgatg
tttgtcatcattttatatccactactgtggacatttggcatttcccttaatccaggtacg
aacttgtatggtgccaaaatgataccagacaatgcaacatttaaaaattatgcattctta
ctattcgatgacagtagtcaatacctgacttggtataaaaatacgcttatcgtagcatct
gcaaatgcactgtttagtgtgatatttgtcacgttaacagcatatgctttttctagatat
cgctttgttggtcgtaaatacgggctgattacatttttgattttacaaatgttccctgta
ttaatggcaatggtcgcaatctatattttgctaaatacaattggattattagattcttta
tttggactaacactggtatatattggtggatcaataccgatgaatgcctttttagtgaaa
ggttacttcgatacgattccaaaagaacttgatgaatctgccaaaattgatggtgcaggg
catatgcgtattttcttacaaattatgcttccattagctaagccgattttagcagttgtt
gctttgttcaattttatggggccatttatggactttatattacctaaaatactattaaga
agtcctgaaaaattcacattagcagttggattgttcaactttattaatgataagtatgca
aataatttcacagtgtttgcagcaggggcaattatgattgcagtacctatagcaatcgta
ttcttgttcttgcaacgctatttagtatcaggtttaacaacaggtgcgacaaaaggt
52.
gtgatggaaaatagtacgaccgaagcgcgtaatgaagcgacgatgcatcttgatgaaatg
actgtggaagaggctttaattacgatgaataaagaagatcagcaagtcccgttagcagtt
cgaaaggcaataccacaattgacaaaagtaattaaaaaaacaattgcacagtataaaaag
ggtggacgattgatttatatcggtgcaggtacaagtggaaggttgggtgtcttagatgca
gcggagtgtgtacctacattcaatactgaccctcatgaaattataggtattattgctggt
ggacaacatgctatgacgatggctgtagaaggtgcggaagatcacaaaaaattagcggaa
gaagatttgaaaaatatagatttaacatcaaaagatgtcgttataggaattgccgcgagt
ggcaaaacgccatatgttataggcggtttaacatttgctaacacaatcggtgctacaaca
gtatctatttcatgcaatgaacatgcagttataagtgaaattgcgcagtatccagtagaa
gttaaagttggtccagaagtattaactggttcaacacgtttaaagtctggtacagcacaa
aagttaattttaaatatgatttcaaccatcacaatggttggtgtcggaaaagtttacgat
aacctcatgattgatgttaaagcaaccaatcaaaaactgatcgaccgttcagtgcgtatt
attcaagaaatatgtgctatcacatatgatgaagcaatggcgttatatcaggtatctgag
catgatgtgaaagttgcgacagttatgggtatgtgtggcatttctaaggaagaagcaaca
agacggttattaaacaatggtgacattgttaaacgagcaatcagagatagacaacct
53.
ttgcaatacataattcgttatattatgatgactttacaaatacatacagggggtattaat
ttgaaaaagaaaaacatttattcaattcgtaaactaggtgtaggtattgcatctgtaact
ttaggtacattacttatatctggtggcgtaacacctgctgcaaatgctgcgcaacacgat
gaagctcaacaaaatgctttttatcaagtcttaaatatgcctaacttaaatgctgatcaa
cgcaatggttttatccaaagccttaaagatgatccaagccaaagtgctaacgttttaggt
gaagctcaaaaacttaatgactctcaagctccaaaagctgatgcgcaacaaaataacttc
aacaaagatcaacaaagcgccttctatgaaatcttgaacatgcctaacttaaacgaagcg
caacgtaacggcttcattcaaagtcttaaagacgacccaagccaaagcactaacgtttta
ggtgaagctaaaaaattaaacgaatctcaagcaccgaaagctgataacaatttcaacaaa
gaacaacaaaatgctttctatgaaatcttgaatatgcctaacttaaacgaagaacaacgc
aatggtttcatccaaagcttaaaagatgacccaagccaaagtgctaacctattgtcagaa
gctaaaaagttaaatgaatctcaagcaccgaaagcggataacaaattcaacaaagaacaa
caaaatgctttctatgaaatcttacatttacctaacttaaacgaagaacaacgcaatggt
ttcatccaaagcctaaaagatgacccaagccaaagcgctaaccttttagcagaagctaaa
aagctaaatgatgctcaagcaccaaaagctgacaacaaattcaacaaagaacaacaaaat
gctttctatgaaattttacatttacctaacttaactgaagaacaacgtaacggcttcatc
caaagccttaaagacgatccttcagtgagcaaagaaattttagcagaagctaaaaagcta
aacgatgctcaagcaccaaaagaggaagacaataacaagcctggcaaagaagacaataac
aagcctggcaaagaagacaacaacaagcctggtaaagaagacaacaacaagcctggcaaa
gaagacggcaacaagcctggtaaagaagacaacaaaaaacctggtaaagaagatggcaac
aagcctggtaaagaagacaacaaaaaacctggtaaagaagacggcaacaagcctggcaaa
gaagatggcaacaaacctggtaaagaagatggtaacggagtacatgtcgttaaacctggt
gatacagtaaatgacattgcaaaagcaaacggcactactgctgacaaaattgctgcagat
aacaaattagctgataaaaacatgatcaaacctggtcaagaacttgttgttgataagaag
caaccagcaaaccatgcagatgctaacaaagctcaagcattaccagaaactggtgaagaa
aatccattcatcggtacaactgtatttggtggattatcattagccttaggtgcagcgtta
ttagctggacgtcgtcgcgaacta
54.
ttggataaaaagtctgagaagcggggcattaaaatgacggtacaaagtgcatatatacat
attccattttgtgtaagaatatgtacatattgtgatttcaataaatattttatacagaat
caacctgtagatgagtacttagatgcactaatcacagaaatgtctacagcaaaatatagg
atcttaaagaccatgtatgtaggtggcggcacaccaacggccctttctattaatcagttg
gaaagattacttaaagcaatacgtgatacgtttacaatcacaggcgagtatacatttgaa
gcaaatcctgatgagttaactaaagagaaagtccaactattagagaaatatggagtaaaa
aggatttcaatgggcgttcaaacattcaagccggagttattgtctgttttaggtagaacg
cacaatactgaagatatttacacttcggtgttaaatgctaaaaacgcaggtattaaatca
atcagtttagatttaatgtatcatttaccgaaacagacgattgaagattttgaacaaagt
ttagatctagctttagatatggatattcaacatatttcgagttacggcttaatacttgaa
cctaaaacccaattttataatatgtatagaaaaggcttgctcaaacttcctaatgaggat
ttaggtgctgacatgtatcagttgctgatgtctaagatagaacaatctcctttccatcaa
tacgaaatatctaattttgcattagatggccatgaatcagaacataataaggtttactgg
tttaatgaggaatattatggatttggagcaggtgcaagtggttatgtagatggtgtgcgt
tatacgaatatcaatccagtgaatcattatatcaaagctataaataaagaaagtaaagca
attttagtatcaaataaaccttctttgactgagagaatggaagaagaaatgtttcttggg
ttgcgtttaaatgaaggtgtgagtagtagtaggttcaaaaagaagtttgaccaatctatt
gaaagtgtctttggtcaaacaataaataatttaaaagagaaggaattaattgtagaaaag
aacgatgtgattgcacttacaaatagagggaaagtcataggtaatgaggtttttgaagct
ttcctaataaatgat
55.
MRNIENLNPGDSVDHFFLVHKATQGVTAQGKDYMTLHLQDKSGEIEAKFWTATKNDMATI
KPEEIVHVKGDIINYRGNKQMKVNQIRLATTEDQLKTEQFVDGAPLSPAEIQEEISHYLL
DIENANLQRITRHLLKKYQERFYTYPAASSHHHNFASGLSYHVLTMLRIAKSICDIYPLL
NKSLLYSGIILHDIGKVRELSGPVATSYTVEGNLLGHISIASDEVVEAARELNIEGEEIM
LLRHMILSHHGKLEYGSPKLPYLKEAEILCYIDNIDARMNMFEKAYKKTDKGQFTDKIFG
LENRRFYNPESLD
56.
MNKHHPKLRSFYSIRKSTLGVASVIVSTLFLITSQHQAQAAENTNTSDKISENQNNNATT
TQPPKDTNQTQPATQPANTAKNYPAADESLKDAIKDPALENKEHDIGPREQVNFQLLDKN
NETQYYHFFSIKDPADVYYTKKKAEVELDINTASTWKKFEVYENNQKLPVRLVSYSPVPE
DHAYIRFPVSDGTQELKIVSSTQIDDGEETNYDYTKLVFAKPIYNDPSLVKSDTNDAVVT
NDQSSSVASNQTNTNTSNQNTSTINNANNQPQATTNMSQPAQPKSSTNADQASSQPAHET
NSNGNTNDKTNESSNQSDVNQQYPPADESLQDAIKNPAIIDKEHTADNWRPIDFQMKNDK
GERQFYHYASTVEPATVIFTKTGPIIELGLKTASTWKKFEVYEGDKKLPVELVSYDSDKD
YAYIRFPVSNGTREVKIVSSIEYGENIHEDYDYTLMVFAQPITNNPDDYVDEETYNLQKL
LAPYHKAKTLERQVYELEKLQEKLPEKYKAEYKKKLDQTRVELADQVKSAVTEFENVTPT
NDQLTDLQEAHFVVFESEENSESVMDGFVEHPFYTATLNGQKYVVMKTKDDSYWKDLIVE
GKRVTTVSKDPKNNSRTLIFPYIPDKAVYNAIVKVVVANIGYEGQYHVRIINQDINTKDD
DTSQNNTSEPLNVQTGQEGKVADTDVAENSSTATNPKDASDKADVIEPESDVVKDADNNI
DKDVQHDVDHLSDMSDNNHFDKYDLKEMDTQIAKDTDRNVDKDADNSVGMSSNVDTDKDS
NKNKDKVIQLNHIADKNNHTGKAAKLDVVKQNYNNTDKVTDKKTTEHLPSDIHKTVDKTV
KTKEKAGTPSKENKLSQSKMLPKTGETTSSQSWWGLYALLGMLALFIPKFRKESK
57.
Msdfnhtdhsttnhsqtpryrrpkfpwfktvivaliagiigallvlgigkvlnstilnkd
Gstvqttnnkggnqldgqskkfgtvhemiksvsptivgvinmqkassvddllkgksskps
Eagvgsgviyqinnnsayivtnnhvidganeirvqlhnkkqvkaklvgkdavtdiavlki
Entkgikaiqfansskvqtgdsvfamgnplglqfansvtsgiisasertidaettggntk
Vsvlqtdaainpgnsggalvdingnlvginsmkiaatqvegigfaipsnevkvtieqlvk
Hgkidrpsigiglinlkdipeeereqlhtdredgiyvakadsdidlkkgdiiteidgkki
Kddvdlrsylyenkkpgesvtvtvirdgktkevkvklkqqkeqpkrqsrserqspgqgdr
dffr
58.
VNQQQEKTTTTPTTINPLTGEKVGEGEPTTEVTKEPVDEITQFGGEEVPQGHKDEFDPNL
PIDGTEEVPGKPGIKNPETGEVVTPPVDDVTKHGPKAGEPEVTKEEIPFEKKREFNPDLK
PGEEKVTQEGQTGEKTTTTPTTINPLTGEKVGEGEPTTEVTKEPVDEITQFGGEEVPQGH
KDEFDPNLPIDGTEEVPGKPGIKNPETGEVVTPPVDDVTKHGPKAGEPEVTKEEIPYETK
RVLDPTMEPGSPDKVAQKGENGEKTTTTPTTINPLTGEKVGEGEPTTEVTKEPIDEIVNY
APEIIPHGTREEIDPNLPEGETKVIPGKDGLKDPETGEIIEEPQDEVIIHGAKDDSDADS
DSDADSDSDADSDSDADSDSDADSDSDSDSDSDSDSDSDADSDSDADSDSDSDSDSDADS
DSDADSDSDADSDSDADSDSDSDSDSDADSDSDSDSDSDADSDSDADSDSDADSDSDADS
DSDSDSDSDADSDSDSDSDSDSDADSDSDSDSDADSDSDADSDSDADSDSDADSDSDSDS
DSDSDSDSDSDSDRDSDADSDSDADSDSDSDSDSDADSDSDSDSDSDADSDSDADSDSDS
DADSDSDSDSDSDADSDSDADSDSDADSDSDADSDSDSDSDSDSDSDSDADSDSDADSDS
DADRDHNDKTDKPNNKELPDTGNDAQNNGTLFGSLFAALGGLFLVGRRRKNKNNEEK
59.
MKSLKTVIGMNNKEHIKSVILALLVLMSVVLTYMVWNFSPDIANVDNTDSKKSETKPLTT
PMTAKMDTTITPFQIIHSKNDHPEGTIATVSNVNKLTKPLKNKEVKSVEHVRRDHNLMIP
DLNSDFILFDFTYDLPLSTYLGQVLNMNAKVPNHFNFNRLVIDHDADDNIVLYAISKDRH
DYVKLTTTTKNDHFLDALAAVKKDMQPYTDIITNKDTIDRTTHVFAPSKPEKLKTYRMVF
NTISVEKMNAILFDDSTIVRSSKSGVTTYNNNTGVANYNDKNEKYHYKNLSEDEASSSKM
EETIPGTFDFINGHGGFLNEDFRLFSTNNQSGELTYQRFLNGYPTFNKEGSNQIQVTWGE
KGVFDYRRSLLRTDVVLNSEDNKSLPKLESVRSSLANNSDINFEKVTNIAIGYEMQDNSD
HNHIEVQINSELVPRWYVEYDGEWYVYNDGRLE
60.
MSKRQKAFHDSLANEKTRVRLYKSGKNWVKSGIKEIEMFKIMGLPFISHSLVSQDNQSIS
KKMTGYGLKTTAVIGGAFTVNMLHDQQAFAASDAPLTSELNTQSETVGNQNSTTIEASTS
TADSTSVTKNSSSVQTSNSDTVSSEKSEKVTSTTNSTSNQQEKLTSTSESTSSKNTTSSS
DTKSVASTSSTEQPINTSTNQSTASNNTSQSTTPSSVNLNKTSTTSTSTAPVKLRTFSRL
AMSTFASAATTTAVTANTITVNKDNLKQYMTTSGNATYDQSTGIVTLTQDAYSQKGAITL
GTRIDSNKSFHFSGKVNLGNKYEGHGNGGDGIGFAFSPGVLGETGLNGAAVGIGGLSNAF
GFKLDTYHNTSKPNSAAKANADPSNVAGGGAFGAFVTTDSYGVATTYTSSSTADNAAKLN
VQPTNNTFQDFDINYNGDTKVMTVKYAGQTWTRNISDWIAKSGTTNFSLSMTASTGGATN
LQQVQFGTFEYTESAVTQVRYVDVTTGKDIIPPKTYSGNVDQVVTIDNQQSALTAKGYNY
TSVDSSYASTYNDTNKTVKMTNAGQSVTYYFTDVKAPTVTVGNQTIEVGKTMNPIVLTTT
DNGTGTVTNTVTGLPSGLSYDSATNSIIGTPTKIGQSTVTVVSTDQANNKSTTTFTINVV
DTTAPTVTPIGDQSSEVYSPISPIKIATQDNSGNAVTNTVTGLPSGLTFDSTNNTISGTP
TNIGTSTISIVSTDASGNKTTTTFKYEVTRNSMSDSVSTSGSTQQSQSVSTSKADSQSAS
TSTSGSIVVSTSASTSKSTSVSLSDSVSASKSLSTSESNSVSSSTSTSLVNSQSVSSSMS
DSASKSTSLSDSISNSSSTEKSESLSTSTSDSLRTSTSLSDSLSMSTSGSLSKSQSLSTS
ISGSSSTSASLSDSTSNAISTSTSLSESASTSDSISISNSIANSQSASTSKSDSQSTSIS
LSTSDSKSMSTSESLSDSTSTSGSVSGSLSIAASQSVSTSTSDSMSTSEIVSDSISTSGS
LSASDSKSMSVSSSMSTSQSGSTSESLSDSQSTSDSDSKSLSQSTSQSGSTSTSTSTSAS
VRTSESQSTSGSMSASQSDSMSISTSFSDSTSDSKSASTASSESISQSASTSTSGSVSTS
TSLSTSNSERTSTSMSDSTSLSTSESDSISESTSTSDSISEAISASESTFISLSESNSTS
DSESQSASAFLSESLSESTSESTSESVSSSTSESTSLSDSTSESGSTSTSLSNSTSGSTS
ISTSTSISESTSTFKSESVSTSLSMSTSTSLSDSTSLSTSLSDSTSDSKSDSLSTSMSTS
DSISTSKSDSISTSTSLSGSTSESKSDSTSMSISMSQSTSGSTSTSTSTSLSDSTSTSLS
LSASMNQSGVDSNSASQSASNSTSTSTSESDSQSTSSYTSQSTSQSESTSTSTSLSDSTS
ISKSTSQSGSVSTSASLSGSESESDSQSISTSASESTSESASTSLSDSTSTSNSGSASTS
TSLSNSASASESDLSSTSLSDSTSASMQSSESDSQSTSASLSDSLSTSTSNRMSTIASLS
TSVSTSESGSTSESTSESDSTSTSLSDSQSTSRSTSASGSASTSTSTSDSRSTSASTSTS
MRTSTSDSQSMSLSTSTSTSMSDSTSLSDSVSDSTSDSTSASTSGSMSVSISLSDSTSTS
TSASEVMSASISDSQSMSESVNDSESVSESNSESDSKSMSGSTSVSDSGSLSVSTSLRKS
ESVSESSSLSCSQSMSDSVSTSDSSSLSVSTSLRSSESVSESDSLSDSKSTSGSTSTSTS
GSLSTSTSLSGSESVSESTSLSDSISMSDSTSTSDSDSLSGSISLSGSTSLSTSDSLSDS
KSLSSSQSMSGSESTSTSVSDSQSSSTSNSQFDSMSISASESDSMSTSDSSSISGSNSTS
TSLSTSDSMSGSVSVSTSTSLSDSISGSTSVSDSSSTSTSTSLSDSMSQSQSTSTSASGS
LSTSISTSMSMSASTSSSQSTSVSTSLSTSDSISDSTSISISGSQSTVESESTSDSTSIS
DSESLSTSDSDSTSTSTSDSTSGSTSTSISESLSTSGSGSTSVSDSTSMSESNSSSVSMS
QDKSDSTSISDSESVSTSTSTSLSTSDSTSTSESLSTSMSGSQSISDSTSTSMSGSTSTS
ESNSMHPSDSMSMHHTHSTSTSRLSSEATTSTSESQSTLSATSEVTKHNGTPAQSEKRLP
DTGDSIKQNGLLGGVMTLLVGLGLMKRKKKKDENDQDDSQA
61.
MPKNKILIYLLSTTLVLPTLVSPTAYADTPQKDTTAKTTSHDSKKSNDDETSKDTTSKDI
DKADKNNTSNQDNNDKKFKTIDDSTSDSNNIIDFIYKNLPQTNINQLLTKNKYDDNYSLT
TLIQNLFNLNSDISDYEQPRNGEKSTNDSNKNSDNSIKNDTDTQSSKQDKADNQKAPKSN
NTKPSTSNKQPNSPKPTQPNQSNSQPASDDKANQKSSSKDNQSMSDSALDSILDQYSEDA
KKTQKDYASQSKKDKNEKSNTKNPQLPTQDELKHKSKPAQSFNNDVNQKDTRATSLFETD
PSISNNDDSGQFNVVDSKDTRQFVKSIAKDAHRIGQDNDIYASVMIAQAILESDSGRSAL
AKSPNHNLFGIKGAFEGNSVPFNTLEADGNQLYSINAGFRKYPSTKESLKDYSDLIKNGI
DGNRTIYKPTWKSEADSYKDATSHLSKTYATDPNYAKKLNSIIKHYQLTQFDDERMPDLD
KYERSIKDYDDSSDEFKPFREVSDSMPYPHGQCTWYVYNRMKQFGTSISGDLGDAHNWNN
RAQYRDYQVSHTPKRHAAVVFEAGQFGADQHYGHVAFVEKVNSDGSIVISESNVKGLGII
SHRTINAAAAEELSYITGK
62.
MRKFSRYAFTSMAALTLLSTLSPAALAIDSKNKPANSDIKFEVTQKSDAVKALKELPKSE
NVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAK
KVKPTNKVTLSKDDAADKAFKAVKIDKNKAKNLKDKVIKENKVEIDGDSNKYVYNVELIT
VTPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT
HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDN
QGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTFTSLSGANDVVAHELTHGVTQ
ETANLEYKDQSGALNESFSDVFGYFVDDEDFLMGEDVYTPGKEGDALRSMSNPEQFGQPA
HMKDYVFTEKDNGGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCK
DALYQAAKDLYDEQTAEQVYEAWNEVGVE
63.
MKKRIDYLSNKQNKYSIRRFTVGTTSVIVGATILFGIGNHQAQASEQSNDTTQSSKNNAS
ADSEKNNMIETPQLNTTANDTSDISANTNSANVDSTTKPMSTQTSNTTTTEPASTNETPQ
PTAIKNQATAAKMQDQTVPQEANSQVDNKTTNDANSIATNSELKNSQTLDLPQSSPQTIS
NAQGTSKPSVRTRAVRSLAVAEPVVNAADAKGTNVNDKVTASNFKLEKTTFDPNQSGNTF
MAANFTVTDKVKSGDYFTAKLPDSLTGNGDVDYSNSNNTMPIADIKSTNGDVVAKATYDI
LTKTYTFVFTDYVNNKENINGQFSLPLFTDRAKAPKSGTYDANINIADEMFNNKITYNYS
SPIAGIDKPNGANISSQIIGVDTASGQNTYKQTVFVNPKQRVLGNTWVYIKGYQDKIEES
SGKVSATDTKLRIFEVNDTSKLSDSYYADPNDSNLKEVTDQFKNRIYYEHPNVASIKFGD
ITKTYVVLVEGHYDNTGKNLKTQVIQENVDPVTNRDYSIFGWNNENVVRYGGGSADGDSA
VNPKDPTPGPPVDPEPSPDPEPEPTPDPEPSPDPEPEPSPDPDPDSDSDSDSGSDSDSGS
DSDSESDSDSDSDSDSDSDSDSESDSDSESDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS
DSDSESDSDSESDSESDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS
DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS
DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS
RVTPPNNEQKAPSNPKGEVNHSNKVSKQHKTDALPETGDKSENTNATLFGAMMALLGSLL
LFRKRKQDHKEKA
64.
MKKTIMASSLAVALGVTGYAAGTGHQAHAAEVNVDQAHLVDLAHNHQDQLNAAPIKDGAY
DIHFVKDGFQYNFTSNGTTWSWSYEAANGQTAGFSNVAGADYTTSYNQGSNVQSVSYNAQ
SSNSNVEAVSAPTYHNYSTSTTSSSVRLSNGNTAGATGSSAAQIMAQRTGVSASTWAAII
ARESNGQVNAYNPSGASGLFQTMPGWGPTNTVDQQINAAVKAYKAQGLGAWGF
65.
MGGYLIMKKIVTATIATAGLATIAFAGHDAQAAEQNNNGYNSNDAQSYSYTYTIDAQGNY
HYTWTGNWNPSQLTQNNTYYYNNYNTYSYNNASYNNYYNHSYQYNNYTNNSQTATNNYYT
GGSGASYSTTSNNVHVTTTAAPSSNGRSISNGYASGSNLYTSGQCTYYVFDRVGGKIGST
WGNASNWANAAASSGYTVNNTPKVGAIMQTTQGYYGHVAYVEGVNSNGSVRVSEMNYGHG
AGVVTSRTISANQAGSYNFIH
66.
MANTKKTTLDITGMTCAACSNRIEKKLNKLDDVNAQVNLTTEKATVEYNPDQHDVQEFIN
TIQHLGYGVAVETVELDITGMTCAACSSRIEKVLNKMDGVQNATVNLTTEQAKVDYYPEE
TDADKLVTRIQKLGYDASIKDNNKDQTSRKAEALQHKLIKLIISAVLSLPLLMLMFVHLF
NMHIPALFTNPWFQFILATPVQFIIGWQFYVGAYKNLRNGGANMDVLVAVGTSAAYFYSI
YEMVRWLNGSTTQPHLYFETSAVLITLILFGKYLEARAKSQTTNALGELLSLQAKEARIL
KDGNEVMIPLNEVHVGDTLIVKPGEKIPVDGKIIKGMTAIDESMLTGESIPVEKNVDDTV
IGSTMNKNGTITMTATKVGGDTALANIIKVVEEAQSSKAPIQRLADIISGYFVPIVVGIA
LLTFIVWITLVTPGTFEPALVASISVLVIACPCALGLATPTSIMVGTGRAAENGILFKGG
EFVERTHQIDTIVLDKTGTITNGRPVVTDYHGDNQTLQLLATAEKDSEHPLAEAIVNYAK
EKQLILTETTTFKAVPGHGIEATIDHHHILVGNRKLMADNDISLPKHISDDLTHYERDGK
TAMLIAVNYSLTGIIAVADTVKDHAKDAIKQLHDMGIEVAMLTGDNKNTAQAIAKQVGID
TVIADILPEEKAAQIAKLQQQGKKVAMVGDGVNDAPALVKADIGIAIGTGTEVAIEAADI
TILGGDLMLIPKAIYASKATIRNIRQNLFWAFGYNIAGIPIAALGLLAPWVAGAAMALSS
VSVVTNALRLKKMRLEPRRKDA
67.
MFDSIRETIDYAVENNMSFADIMVKEEMELSGKSRDEVRAQMKQNLDVMRDAVIKGTTGD
GVESVTGYTGHDAAKLRDYNETHHALSGYEMIDAVKGAIATNEVNAAMGIICATPTAGSS
GTIPGALFKLEKTHDLTEEQMIDFLFTSALFGRVVANNASVAGATGGCQAEVGSASAMAA
AAAVAIFGGSPEASGHAMALAISNLLGLVCDPVAGLVEIPCVMRNAIGSGNALISADLAL
AGIESRIPVDEVIEAMDKVGRNLPASLRETGLGGLAGTPTGEAIKRKIFGTAEDMVKNN
68.
MKNNLRYGIRKHKLGAASVFLGTMIVVGMGQDKEAAASEQKTTTVEENGNSATDNKTSET
QTTATNVNHIEETQSYNATVTEQPSNATQVTTEEAPKAVQAPQTAQPANIETVKEEVVKE
EAKPQVKETTQSQDNSGDQRQVDLTPKKATQNQVAETQVEVAQPRTASESKPRVTRSADV
AEAKEASNAKVETGTDVTSKVTVEIGSIEGHNNTNKVEPHAGQRAVLKYKLKFENGLHQG
DYFDFTLSNNVNTHGVSTARKVPEIKNGSVVMATGEVLEGGKIRYTFTNDIEDKVDVTAE
LEINLFIDPKTVQTNGNQTITSTLNEEQTSKELDVKYKDGIGNYYANLNGSIETFNKANN
RFSHVAFIKPNNGKTTSVTVTGTLMKGSNQNGNQPKVRIFEYLGNNEDIAKSVYANTTDT
SKFKEVTSNMSGNLNLQNNGSYSLNIENLDKTYVVHYDGEYLNGTDEVDFRTQMVGHPEQ
LYKYYYDRGYTLTWDNGLVLYSNKANGNGKNGPIIQNNKFEYKEDTIKETLTGQYDKNLV
TTVEEEYDSSTLDIDYHTAIDGGGGYVDGYIETIEETDSSAIDIDYHTAVDSEAGHVGGY
TESSEESNPIDFEESTHENSKHHADVVEYEEDTNPGGGQVTTESNLVEFDEESTKGIVTG
AVSDHTTVEDTKEYTTESNLIELVDELPEEHGQAQGPVEEITENNHHISHSGLGTENGHG
NYDVIEEIEENSHVDIKSELGYEGGQNSGNQSFEEDTEEDKPKYEQGGNIVDIDFDSVPQ
IHGQNKGNQSFEEDTEKDKPKYEHGGNIIDIDFDSVPHIHGFNKHTEIIEEDTNKDKPSY
QFGGHNSVDFEEDTLPKVSGQNEGQQTIEEDTTPPIVPPTPPTPEVPSEPETPTPPTPEV
PSEPETPTPPTPEVPSEPETPTPPTPEVPAEPGKPVPPAKEEPKKPSKPVEQGKVVTPVI
EINEKVKAVAPTKKPQSKKSELPETGGEESTNKGMLFGGLFSILGLALLRRNKKNHKA
69.
LHLRENIIVKSNLRYGIRKHKLGAASVFLGTMIVVGMGQEKEAAASEQNNTTVEESGSSA
TESKASETQTTTNNVNTIDETQSYSATSTEQPSQSTQVTTEEAPKTVQAPKVETSRVDLP
SEKVADKETTGTQVDIAQPSNVSEIKPRMKRSTDVTAVAEKEVVEETKATGTDVTNKVEV
EEGSEIVGHKQDTNVVNPHNAERVTLKYKWKFGEGIKAGDYFDFTLSDNVETHGISTLRK
VPEIKSTDGQVMATGEIIGERKVRYTFKEYVQEKKDLTAELSLNLFIDPTTVTQKGNQNV
EVKLGETTVSKIFNIQYLGGVRDNWGVTANGRIDTLNKVDGKFSHFAYMKPNNQSLSSVT
VTGQVTKGNKPGVNNPTVKVYKHIGSDDLAESVYAKLDDVSKFEDVTDNMSLDFDTNGGY
SLNFNNLDQSKNYVIKYEGYYDSNASNLEFQTHLFGYYNYYYTSNLTWKNGVAFYSNNAQ
GDGKDKLKEPIIEHSTPIELEFKSEPPVEKHELTGTIEESNDSKPIDFEYHTAVEGAEGH
AEGTIETEEDSIHVDFEESTHENSKHHADVVEYEEDTNPGGGQVTTESNLVEFDEDSTKG
IVTGAVSDHTTIEDTKEYTTESNLIELVDELPEEHGQAQGPIEEITENNHHISHSGLGTE
NGHGNYGVIEEIEENSHVDIKSELGYEGGQNSGNQSFEEDTEEDKPKYEQGGNIVDIDFD
SVPQIHGQNNGNQSFEEDTEKDKPKYEQGGNIIDIDFDSVPHIHGFNKHTEIIEEDTNKD
KPNYQFGGHNSVDFEEDTLPQVSGHNEGQQTIEEDTTPPIVPPTPPTPEVPSEPETPTPP
TPEVPSEPETPTPPTPEVPTEPGKPIPPAKEEPKKPSKPVEQGKVVTPVIEINEKVKAVV
PTKKAQSKKSELPETGGEESTNNGMLFGGLFSILGLALLRRNKKNHKA
70.
MQMRDKKGPVNKRVDFLSNKLNKYSIRKFTVGTASILIGSLMYLGTQQEAEAAENNIENP
TTLKDNVQSKEVKIEEVTNKDTAPQGVEAKSEVTSNKDTIEHEPSVKAEDISKKEDTPKE
VADVAEVQPKSSVTHNAETPKVRKARSVDEGSFDITRDSKNVVESTPITIQGKEHFEGYG
SVDIQKKPTDLGVSEVTRFNVGNESNGLIGALQLKNKIDFSKDFNFKVRVANNHQSNTTG
ADGWGFLFSKGNAEEYLTNGGILGDKGLVNSGGFKIDTGYIYTSSMDKTEKQAGQGYRGY
GAFVKNDSSGNSQMVGENIDKSKTNFLNYADNSTNTSDGKFHGQRLNDVILTYVASTGKM
RAEYAGKTWETSITDLGLSKNQAYNFLITSSQRWGLNQGINANGWMRTDLKGSEFTFTPE
APKTITELEKKVEEIPFKKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGVIIS
KGEPKEEITKDPINELTEYGPETIAPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVR
PPVDSVTKYGPVKGDSIVEKEEIPFXKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKN
PLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKN
PETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFKKERKFNPDLAPGTEKVTREGQKGEKT
ITTPTLKNPLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEV
PGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFEKERKFNPDLAPGTEKVTR
EGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPVNELTEFGGEKIPQGHKDIFDPNL
PTDQTEKVPGKPGIKNPDTGKVIEEPVDDVIKHGPKTGTPETKTVEIPFETKREFNPKLQ
PGEERVKQEGQPGSKTITTPITVNPLTGEKVGEGQPTEEITKQPVDKIVEFGGEKPKDPK
GPENPEKPSRPTHPSGPVNPNNPGLSKDRAKPNGPVHSMDKNDKVKKSKIAKESVANQEK
KRAELPKTGLESTQKGLIFSSIIGIAGLMLLARRRKN
71.
MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLH
LKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQE
KNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEAN
SKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKA
PMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKVESPKVEVPQIQSPKVE
VPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYYNTYYKYKGAIDQTVLTVL
GSGSKSYIQPLKVDDKNGYLAKSYAQVRNYVTESINTGKVLYTFYQNPTLVKTAIKAQET
ASSIKNTLSNLLSFWK
72.
MAVFSKEKKRGCIVVIETFKAFVIDKDESGKVTPTFKQLSPTDLPKGDVLIKVHYSGINY
KDALATQDHNAVVKSYPMIPGIDLAGTIVESEAPGFEKGEQVIVTSYDLGVSHYGGFSEY
ARVKSEWIIKLPDTLTLEESMIYGTAGYTAGLAIERLEKVGMNIEDGPVLVRGASGGVGT
LAVLMLNELGYKVIASTGKQDVSDQLLELGAKEVIDRLPVEDDHKKPLASSTWQACVDPV
GGEGINYVTKRLNHSGSIAVIGMTAGNTYTNSVFPHILRGVNILGIDSVFTAMKLRQRVW
RRLAKDLMPENLHEIKQVITFDELPEQLNKVIKHENKGRIVIDFGVDK
73.
MKKLVTATTLTAGIGTALVGQAYHADAAENYTNYNNYNYNTTQTTTTTTTTTTTSSISHS
GNLYTAGQCTWYVYDKVGGEIGSTWGNANNWAAAAQGAGFTVNHTPSKGAILQSSEGPFG
HVAYVESVNSDGSVTISEMNYSGGPFSVSSRTISASEAGNYNYIHI
74.
MKKIATATIATAGFATIAIASGNQAHASEQDNYGYNPNDPTSYSYTYTIDAQGNYHYTWK
GNWHPSQLNQDNGYYSYYYYNGYNNYNNYNNGYSYNNYSRYNNYSNNNQSYNYNNYNSYN
TNSYRTGGLGASYSTSSNNVQVTTTMAPSSNGRSISSGYTSGRNLYTSGQCTYYVFDRVG
GKIGSTWGNASNWANAAARAGYTVNNTPKAGAIMQTTQGAYGHVAYVESVNSNGSVRVSE
MNYGYGPGVVTSRTISASQAAGYNFIH
75.
MSMTYRIKKWQKLSTITLLMAGVITLNGGEFRSVDKHQIAVADTNVQTPDYEKLRNTWLD
VNYGYDKYDENNPDMKKKFDATEKEATNLLKEMKTESGRKYLWSGAETLETNSSHMTRTY
RNIEKIAEAMRNPKTTLNTDENKKKVKDALEWLHKNAYGKEPDKKVKELSENFTKTTGKN
TNLNWWDYEIGTPKSLTNTLILLNDQFSNEEKKKFTAPIKTFAPDSDKILSSVGKAELAK
GGNLVDISKVKLLECIIEEDKDMMKKSIDSFNKVFTXVQDSATGKERNGFYKDGSYIDHQ
DVPYTGAYGVVLLEGISQMMPMIKETPFNDKTQNDTTLKSWIDDGFMPLIYKGEMMDLSR
GRAISRENETSHSASATVMKSLLRLSDAMDDSTKAKYKKIVKSSVESDSSYKQNDYLNSY
SDIDKMKSLMTDNSISKNGLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNVARYESIN
GENLKGWHTGAGMSYLYNSDVKHYHDNFWVTADMKRLSGTTTLDNEILKDTDDKKSSKTF
VGGTKVDDQHASIGMDFENQDKTLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENR
KANGYTLYTDDKQTTNSDNQENNSVFLESTDTKKNIGYHFLNKPKITVKKESHTGKWKEI
NKSQKDTQKTDEYYEVTQKHSNSDNKYGYVLYPGLSKDVFKTKKDEVTVVKQEDDFHVVK
DNESVWAGVNYSNSTQTFDINNTKVEVKAKGMFILKKKDDNTYECSFYNPESTNSASDIE
SKISMTGYSITNKNTSTSNESGVHFELTK
76.
MNDLKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLK
FSALLINVLPLCGTFVASN
77.
VSREMSYHWFKKMLLSTSILILSSSSLGLATHTVEAKDNLNGEKPTTNLNHNITSPSVNS
EMNNNETGTPHESNQTGNEGTGSNSRDANPDSNNVKPDSNNQNPSTDSKPDPNNQNPSPN
PKPDPDNPKPKPDPKPDPDKPKPNPDPKPDPDNPKPNPDPKPDPDKPKPNPDPKPDPDKP
KPNPNPKPDPNKPNPNPSPDPDQPGDSNHSGGSKNGGTWNPNASDGSNQGQWQPNGNQGN
SQNPTGNDFVSQRFLALANGAYKYNPYILNQINKLGKDYGEVTDEDIYNIIRKQNFSGNA
YLNGLQQQSNYFRFQYFNPLKSERYYRNLDEQVLALITGEIGSMPDLKKPEDKPDSKQRS
FEPHEKDDFTVVKKQEDNKKSASTAYSKSWLAIVCSMMVVFSIMLFLFVKRNKKKNKNES
QRR
78.
MKNKKRVLIASSLSCAILLLSAATTQANSAHKDSQDQNKKEHVDKSQQKDKRNVTNKDKN
STAPDDIGKNGKITKRTETVYDEKTNILQNLQFDFIDDPTYDKNVLLVKKQGSIHSNLKF
ESHKEEKNSNWLKYPSEYHVDFQVKRNRKTEILDQLPKNKISTAKVDSTFSYSSGGKFDS
TKGIGRTSSNSYSKTISYNQQNYDTIASGKNNNWHVHWSVIANDLKYGGEVKNRNDELLF
YRNTRIATVENPELSFASKYRYPALVRSGFNPEFLTYLSNEKSNEKTQFEVTYTRNQDIL
KNRPGIHYAPPILEKNKDGQRLIVTYEVDWKNKTVKVVDKYSDDNKPYKEG
79.
MYTRTATTSDSQKNITQSLQFNFLTEPNYDKETVFIKAKGTIGSGLRILDPNGYWNSTLR
WPGSYSVSIQNVDDNNNTNVTDFAPKNQDESREVKYTYGYKTGGDFSINRGGLTGNITKE
SNYSETISYQQPSYRTLLDQSTSHKGVGWKVEAHLINNMGHDHTRQLTNDSDNRTKSEIF
SLTRNGNLWAKDNFTPKDKMPVTVSEGFNPEFLAVMSHDKKDKGKSQFVVHYKRSMDEFK
IDWNRHGFWGYWSGENHVDKKEEKLSALYEVDWKTHNVKFVKVLNDNEKK
80.
VVKFMNYPNGKPYRKNSAIDGGKKTAAFSNIEYGGRGMSLEKDIEHSNTFYLKSDIAVIH
KKPTPVQIVNVNYPKRSKAVINEAYFRTPSTTDYNGVYQGYYIDFEAKETKNKTSFPLNN
IHDHQVEHMKNAYQQKGIVFLMIRFKTLDEVYLLPYSKFEVFWKRYKDNIKXSITVDEIR
KNGYHIPYQYQPRLDYLKAVDKLILDESEDRV
81.
VNTTKAALHGDVKLQNDKDHAKQTVSQLAHLNNAQKHMEDTLIDSETTRTAVKQDLTEAQ
ALDQLMDALQQSIADKDATRASSAYVNAEPNKKQSYDEAVQNAESIIAGLNNPTINKGNV
SSATQAVISSKNALDGVERLAQDKQTAGNSLNHLDQLTPAQQQALENQINNATTRGEVAQ
KLTEAQALNQAMEALRNSIQDQQQTEAGSKFINEDKPQKDAYQAAVQNAKDLINQTNNPT
LDKAQVEQLTQAVNQAKDNLHGDQKLADDKQHAVTDLNQLNGLNNPQRQALESQINNAAT
RGEVAQKLAEAKALDQAMQALRNSIQDQQQTESGSKFINEDKPQKDAYQAAVQNAKDLIN
QTGNPTLDKSQVEQLTQAVTTAKDNLHGDQKLARDQQQAVTTVNALPNLNHAQQQALTDA
INAAPTRTEVAQHVQTATELDHAMETLKNKVDQVNTDKAQPNYTEASTDKKEAVDQALQA
AESITDPTNGSNANKDAVDQVLTKLQEKENELNGNERVAEAKTQAKQTIDQLTHLNADQI
ATAKQNIDQATKLQPIAELVDQATQLNQSMDQLQQAVNEHANVEQTVDYTQADSDKQNAY
KQAIADAENVLKQNANKQQVDQALQNILNAKQALNGDERVALAKTNGKHDIDQLNALNNA
QQDGFKGRIDQSNDLNQIQQIVDEAKALNRAMDQLSQEITDNEGRTKGSTNYVNADTQVK
QVYDETVDKAKQALDKSTGQNLTAKQVIKLNDAVTAAKKALNGEERLNNRKAEALQRLDQ
LTHLNNAQRQLAIQQINNAETLNKASRAINRATKLDNAMGAVQQYIDEQHLGVISSTNYI
NADDNLKANYDNAIANAAHELDKVQGNAIAKAEAEQLKQNIIDAQNALNGDQNLANAKDK
ANAFVNSLNGLNQQQQDLAHKAINNADTVSDVTDIVNNQIDLNDAMETLKHLVDNEIPNA
EQTVNYQNADDNAKTNFDDAKRLANTLLNSDNTNVNDINGAIQAVNDAIHNLNGDQRLQD
AKDKAIQSINQALANKLKEIEASNATDQDKLIAKNKAEELANSIINNINKATSNQAVSQV
QTAGNHAIEQVHANEIPKAKIDANKDVDKQVQALIDEIDRNPNLTDKEKQALKDRINQIL
QQGHNGINNAMTKEEIEQAKAQLAQALQDIKDLVKAKEDAKQDVDKQVQALIDEIDQNPN
LTDKEKQALKDRINQILQQGHXDIXNAMTKEAIEQAKERLAQALQDIKDLVKAKEDAKND
IDKRVQALIDEIDQNPNLTDKEKQALKDRINQILQQGHNDINNALTKEEIEQAKAQLAQA
LQDIKDLVKAKEDAKNAIKALANAKRDQINSNPDLTPEQKAKALKEIDEAEKRALQNVEN
AQTIDQLNRGLNLGLDDIRNTHVWEVDEQPAVNEIFEATPEQILVNGELIVHRDDIITEQ
DILAHINLIDQLSAEVIDTPSTATISDSLTAKVEVTLLDGSKVIVNVPVKVVEKELSVVK
QQAIESIENAAQQKINEINNSVTLTLEQKEAAIAEVNKLKQQAIDHVNNAPDVHSVEEIQ
QQEQAHIEQFNPEQFTIEQAKSNAIKSIEDAIQHMIDEIKARTDLTDKEKQEAIAKLNQL
KEQAIQAIQRAQSIDEISEQLEQFKAQMKAANPTAKELAKRKQEAISRIKDFSNEKINSI
RNSEIGTADEKQAAMNQINEIVLETIRDINNAHTLQQVEAALNNGIARISAVQIVTSDRA
KQSSSTGNESNSHLTIGYGTANHPFNSSTIGHKKKLDEDDDIDPLHMRHFSNNFGNVIKN
AIGVVGISGLLASFWFFIAKRRRKEDEEEELEIRDNNKDSIKETLDDTKHLPLLFAKRRR
KEDEEDVTVEEKDSLNNGESLDKVKHTPFFLPKRRRKEDEEDVEVTNENTDEKVLKDNEH
SPLLFAKRRKDKEEDVETTTSIESKDEDVPLLLAKKKNQKDNQSKDKKSASKNTSKKVAA
KKKKKKAKKNKK
82.
MNQEVKNKIFSILKITFATALFIFVAITLYRELSGINFKDTLVEFSKINRMSLVLLFIGG
GASLVILSMYDVILSRALKMDISLGKVLRVSYIINALNAIVGFGGFIGAGVRAMVYKNYT
HDKKKLVHFISLILISMLTGLSLLSLLIVFHVFDASLILDKITWVRWVLYVVSFFLPLFI
IYSMVRPPDKNNRFVGLYCTLVSCVEWLAAAVVLYFCGVIVDAHVSFMSFIAIFIIAALS
GLVSFIPGGFGAFDLVVLLGFKTLGVPEEKVLLMLLLYRFAYYFVPVIIALILSSFEFGT
SAKKYIEGSKYFIPAKDVTSFLMSYQKDIIAKIPSLSLAILVFFTSMIFFVNNLTIVYDA
LYDGNHLTYYILLAIHTSACLLLLLNVVGIYKQSRRAIIFAMISILLITVATFFTYASYI
LITWLAIIFVLLIVAFRRARRLKRPVRMRNIVAMLLFSLFILYVNHIFIAGTLYALDIYT
IEMHTSVLRYYFWLTILIIAIIIGMIAWLFDYQFSKVRISSKIEDCEEIINQYGGNYLSH
LIYSGDKQFFTNENKTAFLMYRYKASSLVVLGDPLGDENAFDELLEAFYNYAEYLGYDVI
FYQVTDQHMPLYHNFGNQFFKLGEEAIIDLTQFSTSGKKRRGFRATLNKFDELNISFEII
EPPFSTEFINELQHVSDLWLDNRQEMHFSVGEFNEEYLSKAPIGVMRNEENEVIAFCSLM
PTYFNDAISVDLIRWLPELDLPLMDGLYLHMLLWSKEQGYTKFNMGMATLSNVGQLHYSY
LRERLAGRVFEHFNGLYRFQGLRRYKSKYNPNWEPRFLVYRKDNSLWESLSKVMRVIRHK
83.
MVALTLVGSAVTAHQVQAAETTQDQTTNKNVLDSNKVKATTEQAKAEVKNPTQNISGTQV
YQDPAIVQPKTANNKTGNAQVSQKVDTAQVNGDTRANQSATTNNTQPVAKSTSTTAPKTN
TNVTNAGYSLVDDEDDNSENQINPELIKSAAKPAALETQYKTAAPKAATTSAPKAKTEAT
PKVTTFSASAQPRSVAATPKTSLPKYKPQVNSSINDYIRKNNLKAPKIEEDYTSYFPKYA
YRNGVGRPEGIVVHDTANDRSTINGEISYMKNNYQNAFVHAFVDGDRIIETAPTDYLSWG
VGAVGNPRFINVEIVHTHDYASFARSMNNYADYAATQLQYYGLKPDSAEYDGNGTVWTHY
AVSKYLGGTDHADPHGYLRSHNYSYDQLYDLINEKYLIKMGKVAPWGTQSTTTPTTPSKP
TTPSKPSTGKLTVAANNGVAQIKPTNSGLYTTVYDKTGKATNEVQKTFAVSKTATLGNQK
FYLVQDYNSGNKFGWVKEGDVVYNTAKSPVNVNQSYSIKPGTKLYTVPWGTSKQVAGSVS
GSGNQTFKASKQQQIDKSIYLYGSVNGKSGWVSKAYLVDTAKPTPTPTPKPSTPTTNNKL
TVSSLNGVAQINAKNNGLFTTVYDKTGKPTKEVQKTFAVTKEASLGGNKFYLVKDYNSPT
LIGWVKQGDVIYNNAKSPVNVMQTYTVKPGTKLYSVPWGTYKQEAGAVSGTGNQTFKATK
QQQIDKSIYLFGTVNGKSGWVSKAYLAVPAAPKKAVAQPKTAVKAYTVTKPQTTQTVSKI
AQVKPNNTGIRASVYEKTAKNGAKYADRTFYVTKERAHGNETYVLLNNTSHNIPLGWFNV
KDLNVQNLGKEVKTTQKYTVNKSNNGLSMVPWGTKNQVILTGNNIAQGTFNATKQVSVGK
DVYLYGTINNRTGWVNAKDLTAPTAVKPTTSAAKDYNYTYVIKNGNGYYYVTPNSDTAKY
SLKAFNEQPFAVVKEQVINGQTWYYGKLSNGKLAWIKSTDLAKELIKYNQTGMALNQVAQ
IQAGLQYKPQVQRVPGKWTGANFNDVKHAMDTKRLAQDPALKYQFLRLDQPQNISIDKIN
QFLKGKGVLENQGAAFNKAAQMYGINEVYLISHALLETGNGTSQLAKGADVVNNKVVTNS
NTKYHNVFGIAAYDNDPLREGIKYAKQAGWDTVSKAIVGGAKFIGNSYVKAGQNTLYKMR
WNPAHPGTHQYATDVDWANINAKIIKGYYDKIGEVGKYFDIPQYK
84.
MKGKFLKVSSLFVATLTTATLVSSPAANALSSKAMDNHPQQTQSSKQQTPKIQKGGNLKP
LEQREHANVILPNNDRHQITDTTNGHYAPVTYIQVEAPTGTFIASGVVVGKDTLLTNKHV
VDATHGDPHALKAFPSAINQDNYPNGGFTAEQITKYSDEGDLAIVKFSPNEQHKHIGEVV
KPATMSNNADTQVNQNITVTGYPGDKPVATMWESKGKITYLKGEAMQYDLSTTGGNSGSP
VFNEKNEVIGIHWXGVPNEFNGAVFINENVRNFLKQNIEDIHFATMTNLITQIILITLTI
LITLTTQMNQITLTTLTTLIIQTMAIXIIQTIQMQLN
85.
MQKKVIAAIIGTSAISAVAATQANAATTHTVKPGESVWAISNKYGISIAKLKSLNNLTSN
LIFPNQVLKVSGSSNSTSNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQNIMRLNG
LNNFFIYPGQKLKVSGTASSSNAASNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQ
KIMSLNGLNNFFIYPGQKLKVTGNASTNSGSATTTNRGYNTPVFSHQNLYTWGQCTYHVF
NRRAEIGKGISTYWWNANNWDNAAAADGYTIDNRPTVGSIAQTDVGYYGHVMFVERVNND
GSILVSEMNYSAAPGILTYRTVPAYQVNNYRYIH
86.
MNNKKTATNRKGMIPNRLNKFSIRKYSVGTASILVGTTLIFGLSGHEAKAAEHTNGELNQ
SKNETTAPSENKTTKKVDSRQLKDNTQTATADQPKVTMSDSATVKETSSNMQSPQNATAN
QSTTKTSNVTTNDKSSTTYSNETDKSNLTQAKDVSTTPKTTTIKPRTLNRMAVNTVAAPQ
QGTNVNDKVHFSNIDIAIDKGHVNQTTGKTEFWATSSDVLKLKANYTIDDSVKEGDTFTF
KYGQYFRPGSVRLPSQTQNLYNAQGNIIAKGIYDSTTNTTTYTFTNYVDQYTNVRGSFEQ
VAFAKRKNATTDKTAYKMEVTLGNDTYSEEIIVDYGNKKAQPLISSTNYINNEDLSRNMT
AYVNQPKNTYTKQTFVTNLTGYKFNPNAKNFKIYEVTDQNQFVDSFTPDTSKLKDVTDQF
DVIYSNDNKTATVDLMKGQTSSNKQYIIQQVAYPDNSSTDNGKIDYTLDTDKTKYSWSNS
YSNVNGSSTANGDQKKYNLGDYVWEDTNKDGKQDANEKGIKGVYVILKDSNGKELDRTTT
DENGKYQFTGLSNGTYSVEFSTPAGYTPTTANVGTDDAVDSDGLTTTGVIKDADNMTLDS
GFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKGVKVTLQNEKGEVIGTTETDENGKYRFD
NLDSGKYKVIFEKPAGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYEEETSDS
DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS
DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS
DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDNDSDSDSDSDSDAGKHTPAKPMSTV
KDQHKTAKALPETGSENNNSNNGTLFGGLFAALGSLLLFGRRKKQNK
87.
MDINSEEYKQEVLIKDVVMLAARILLESGAEGTRVEDTMTRIAKKLGYSESNSFVTNTVI
QFTLHSESFPRIFRITSRDTNLIKISQANKISRQITNNEISLAEAKTQLEKIYVAKRDSS
LPFKGFAAAMIAMSFLYLQGGRLIDVLTAILAGSLGYLVTEILDRKLHAQFIPEFIGSLV
IGIIAVIGHTLIPTGDLATIIIAAVMPIVPGVLITNAIQDLFGGHMLMFTTKSLEALVTA
FGIGAGVGSVLILV
88.
VIAIMNVIIDERKENAMTFNKVLLSWIVILIITTSIYLFWQLGDINDVFNQSILINVRLP
RLLEALLTGMILTVAGLIFQTVLNNALADSFTLGLASGATFGSGLALFLGLTTLWIPVFS
ITFSLITLITVLVITSVLSQGYPVRILILSGLMIGALFNSLLYFLILLKPRKLNTIANYL
FGGFGDAEYSNVSIIAITFIIALFGIFIILNQLKLLQLGELKSQSLGLNVQLITYIALCI
ASMITAINVAYVGIIGFIGMVIPQLIRKWQWKQSLGRQLALNIVTGGQIMVMADFIGSHI
LSPVQIPASIIIALIGIPVLFYMLISQSKRLH
89.
MKKLAFAITATSGAAAFLTHHDAQASTQHTVQSGESLWSIAQKYNTSVESIKQNNQLDNN
LVFPGQVISVGGSDAQNTSNTSPQAGSASSHTVQAGESLNIIASRYGVSVDQLMAANNLR
GYLIMPNQTLQIPNGGSGGTTPTATTGSNGNASSFNHQNLYTAGQCTWYVFDRRAQAGSP
ISTYWSDAKYWAGNAANDGYQVNNTPSVGSIMQSTPGPYGHVAYVERVNGDGSILISEMN
YTYGPYNMNYRTIPASEVSSYAFIH
90.
MPDSITIIDENKVIDVVLIAGRILLESGAETYRVEDTMNRIAHSYGLHNTYSFVSSTAII
FSLNDRTSTRLIRVQERTTDLEKIALTNSLSRKISNKELTIDEAKSEFIHLQHASLQYSF
LTNFFAAAIACGFFLFMFGGVASDCWIAVIAGGSAFLTFSFVQRYIQIKFFSEFVAAAVV
ISIAATFTKLGIATNQDIITIASVMPLVPGILITNAIRDLLAGELLAGMSRGVEAALTAF
AIGAGVAIVLLII
91.
MGFLSKILDGNNKEIKQLGKLADKVIALEEKTAILTDEEIRNKTKQFQTELADIDNVKKQ
NDYLDKILPEAYALVREGSKRVFNMTPYKVQIMGGIAIHKGDIAEMRTGEGKTLTATMPT
YLNALAGRGVHVITVNEYLSSVQSEEMAELYNFLGLTVGLNLNSKTTEEKREAYAQDITY
STNNELGFDYLRDNMVNYSEDRVMRPLHFAIIDEVDSILIDEARTPLIISGEAEKSTSLY
TQANVFAKMLKQDEDYKYDEKTKAVHLTEQGADKAERMFKVENLYDVQNVDVISHINTAL
RAHVTLQRDVDYMVVDGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVQIQNESKTMAS
ITFQNYFRMYNKLAGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRNDKSDLIYISQKGK
FDAVVEDVVEKHKAGQPVLLGTVAVETSEYISNLLKKRGIRHDVLNAKNHEREAEIVAGA
GQKGAVTIATNMAGRGTDIKLGEGVEELGGLAVIGTERHESRRIDDQLRGRSGRQGDKGD
SRFYLSLQDELMIRFGSERLQKMMSRLGLDDSTPIESKMVSRAVESAQKRVEGNNFDARK
RILEYDEVLRKQREIIYNERNSIIDEEDSSQVVDAMLRSTLQRSINYYINTADDEPEYQP
FIDYINDIFLQEGDITEDDIKGKDAEDIFEVVWAKIEAAYQSQKDILEEQMNEFERMILL
RSIDSHWTDHIDTMDQLRQGIHLRSYAQQNPLRDYQNEGHELFDIMMQNIEEDTCKFILK
SVVQVEDNIEREKTTEFGEAKHVSAEDGKEKVKPKPIVKGDQVGRNDDCPCGSGKKFKNC
HGK
92.
MRESMSNQNYDYNKNEDGSKKKMSTTAKVVSIATVLLLLGGLVFAIFAYVDHSNKAKERM
LNEQKQEQKEKRQKENAEKERKKKQQEEKEQNELDSQANQYQQLPQQNQYQYVPPQQQAP
TKQRPAKEENDDKASKDESKDKDDKASQDKSDDNQKKTDDNKQPAQPKPQPQQPTPKPNN
NQQNNQSNQQAKPQAPQQNSQSTTNKQNNANDK
93.
MNMKKKEKHAIRKKSIGVASVLVGTLIGFGLLSSKEADASENSVTQSDSASNESKSNDSS
SVSAAPKTDDTNVSDTKTSSNTNNGETSVAQNPAQQETTQSSSTNATTEETPVTGEATTT
TTNQANTPATTQSSNTNAEELVNQTSNETTSNDTNTVSSVNSPQNSTNAENVSTTQDTST
EATPSNNESAPQSTDASNKDVVNQAVNTSAPRMRAFSLAAVAADAPAAGTDITNQLTNVT
VGIDSGTTVYPHQAGYVKLNYGFSVPNSAVKGDTFKITVPKELNLNGVTSTAKVPPIMAG
DQVLANGVIDSDGNVIYTFTDYVNTKDDVKATLTMPAYIDPENVKKTGNVTLATGIGSTT
ANKTVLVDYEKYGKFYNLSIKGTIDQIDKTNNTYRQTIYVNPSGDNVIAPVLTGNLKPNT
DSNALIDQQNTSIKVYKVDNAADLSESYFVNPENFEDVTNSVNITFPNPNQYKVEFNTPD
DQITTPYIVVVNGHIDPNSKGDLALRSTLYGYNSNIIWRSMSWDNEVAFNNGSGSGDGID
KPVVPEQPDEPGEIEPIPEDSDSDPGSDSGSDSNSDSGSDSGSDSTSDSGSDSASDSDSA
SDSDSASDSDSASDSDSASDSDSDNDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD
SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD
SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSASDSDSDSDSDSD
SDSDSDSDSDSDSDSDSDSDSDSDSDSESDSDSESDSDSDSDSDSDSDSDSDSDSDSASD
SDSGSDSDSSSDSDSESDSNSDSESGSNNNVVPPNSPKNGTNASNKNEAKDSKEPLPDTG
SEDEANTSLIWGLLASIGSLLLFRRKKENKDKK
94.
MNSNHAKASVTESVDKKFVVPESGINKIIPAYDEFKNSPKVNVSNLTDNKNFVASEDKLN
KIADSSAASKIVDKNFVVPESKLGNIVPEYKEINNRVNVATNNPASQQVDKHFVAKGPEV
NRFITQNKVNHHFITTQTHYKKVITSYKSTHVHKHVNHAKDSINKHFIVKPSESPRYTHP
SQSLIIKHHFAVPGYHAHKFVTPGHASIKINHFCVVPQINSFKVIPPYGHNSHRMHVPSF
QNNTTATHQNAKVNKAYDYKYFYSYKVVKGVKKYFSFSQSNGYKIGKPSLNIKNVNYQYA
VPSYSPTHYVPEFKGSLPAPRV
95.
LEHTIMKMRTIAKTSLALGLLTTGAITVTTQSVKAEKIQSTKVDKVPTLKAERLAMINIT
AGANSATTQAANTRQERTPKLEKAPNTNEEKTSASKIEKISQPKQEEQKTLNISATPAPK
QEQSQTTTESTTPKTKVTTPPSTNTPQPMQSTKSDTPQSPTIKQAQTDMTPKYEDLRAYY
TKPSFEFEKQFGFMLKPWTTVRFMNVIPNRFIYKIALVGKDEKKYKDGPYDNIDVFIVLE
DNKYQLKKYSVGGITKTNSKKVNHKVELSITKKDNQGMISRDVSEYMITKEEISLKELDF
KLRKQLIEKHNLYGNMGSGTIVIKMKNGGKYTFELHKKLQEHRMAGTNIDNIEVNIK
96.
MTTIKTSNLGFPRLGRKREWKKAIESYWAKKISKEELDQTLTDLHKENLLLQKYYHLDSI
PVGDFSLYDHILDTSLLFNIIPERFQGRTIDDDLLFDIARGNKDHVASALIKWFNTNYHY
IVPEWDNVEPKVSRNVLLDRFKYAQSLNVNAHPVIVGPITFVKLSKGGHQTFEEKVKTLL
PLYKEVFESLIDAGAEYIQVDEPILVTDDSESYENITREAYDYFEKAGVAKKLVIQTYFE
RAHLKFLSSLPVGGIGLDFVHDNGYNLKQIEAGDFDKSKTLYAGIIDGRNVWASDIEAKK
VLIDKLLAHTNELVIQPSSSLLHVPVSLDDETLDTSVGEGLSFATEKLDELDALRRLFNQ
NDSVKYDKLKARYERFQNQSFKNLDYDFESVRTSRQSPFAQRIEQQQKRLNLPDLPTTTI
GSFPQSREVRKYRADWKNKRITDEAYETFLKNEIARWIKIQEDIGLDVLVHGEFERNDMV
EFFGEKLQGFLVTKFGWVQSYGSRAVKPPIIYGDVKWTAPLTVDETVYAQSLTDKPVKGM
LTGPVTILNWSFERVDLPRKVVQDQIALAINEEVLALEAAGIKVIQVDEPALREGLPLRS
EYHEQYLKDAVLSFKLATSSVRDETQIHTHMCYSQFGQIIHAIHDLDADVISIETSRSHG
DLIKDFEDINYDLGIGLGVYDIHSPRIPTKEEITTAINRSLQQIDRSLFWVNPDCGLKTR
KEEEVKDALTVLVNAVKAKRQE
97.
MSDTYKSYLVAVLCFTVLAIVLMPFLYFTTAWSIAGFASIATFIFYKEYFYEE
98.
MLRGQEERKYSIRKYSIGVVSVLAATMFVVSSHEAQASEKTSTNAAAQKETLNQPGEQGN
AITSHQMQSGKQLDDMHKENGKSGTVTEGKDTLQSSKHQSTQNSKTIRTQNDNQVKQDSE
RQGSKQSHQNNATNNTERQNDQVQNTHHAERNGSQSTTSQSNDVDKSQPSIPAQKVIPNH
DKAAPTSTTPPSNDKTAPKSTKAQDATTDKHPNQQDTHQPAHQIIDAKQDDTVRQSEQKP
QVGDLSKHIDGQNSPEKPTDKNTDNKQLIKDALQAPKTRSTTNAAADAKKVRPLKANQVQ
PLNKYPVVFVHGFLGLVGDNAPALYPNYWGGNKFKVIEELRKQGYNVHQASVSAFGSNYD
RAVELYYYIKGGRVDYGAAHAAKYGHERYGKTYKGIMPNWEPGKKVHLVGHSMGGQTIRL
MEEFLRNGNKEEIAYHKAHGGEISPLFTGGHNNMVASITTLATPHNGSQAADKFGNTEAV
RKIMFALNRFMGNKYSNIDLGLTQWGFKQLPNESYIDYIKRVSKSKIWTSDDNAAYDLTL
DGSAKLNNMTSMNPNITYTTYTGVSSHTGPLGYENPDLGTFFLMATTSRIIGHDAREEWR
KNDGVVPVISSLHPSNQPFVNVTNDEPATRRGIWQVKPIIQGWD
99.
MIHLIKGKMHHTVLCIHLNKGVALMNQYHSNAQQPSAWRFFVYSLVGILCFFIPFTINGN
NTIFVDHVHLAIRSIIGPLMPYVALIMILIGTALPIVRRTFMTSITNLVITLFKVAGAMI
GIMYVFKIGPSILFKANYGPFLFEKLMMPLSILIPVGAIALSLLVGYGLLEFVGVYMEPI
MRPIFKTPGKSAVDAVASFVGSYSLGLLITNRVYKQGMYNKREATIIATGFSTVSATFMI
IVAKTLGLMPHWNLYFWITLVITFVVTAITAWLPPISNESTEYYNGQEGEQEVAIEGSRL
KTAYAEAMKQNALTPSLVKNVWDNLKDGLEMTVGILPSILSIGFLGLIVANYTPFIDWLG
YIFYPFIYIFPIADQALLAKASAISIVEMFLPSLLVTKAAMSTKFVVGVVSVSAIIFFSA
LVPCILATEIKIPVWKLIIIWFLRVALSLLITIPVALLIFG
100.
MVIMKKTILLTMTTLTLFSMSPNSAQAYTNDSKTLEEAKKAHPNAQFKVNKDTGAYTYTY
DKNNTPNNNHQNQSRTNDNHQHANQRDLNNNQYHSSLSGQYTHINDAIDSHTPPQTSPSN
PLTPAIPNVEDNDDELNNAFSKDNKGLITGIDLDELYDELQIAEFNDKAKTADGKPLALG
NGKIIDQPLITSKNNLYTAGQCTWYVFDKRAKDGHTISTFWGDAKNWAGQASSNGFKVDR
HPTRGSILQTVNGPFGHVAYVEKVNIDGSILISEMNWIGEYIVSSRTISASEVSSYNYIH
101.
MEVSSMKPYIQLVVFKQWLQYILLVTTIVIALVLIGIGYRVAHDNFKIPITIQDLDQTTA
SKSFVNKIKQSDYVTIKKVDEDESYIEDDVTKKEAILSMQIPKGFSQKLKENRLKETIQL
YGRDDFIGGIAVEIVSSSLYEQQIPNIIYEHLEDMKQHQSIDAINKSYHKHTPESKIKFV
SLTKQAQHSISISLIFAVILFVSAVQVVLHYRLNQQAALQRLSQYHLSRFKLYSTYVMTH
TILLLLVLLAVSLYLSQPLSLIFYLKSLLLILIYEIGIVFILFHIQTISHRLFMTFIYAL
AMGIVYLIIFM
102.
MIEVTEMNFFDIHKIPNKGIPLSVQRKLWLRNFMQAFFVVFFVYMAMYLIRNNFKAAQPF
LKEEIGLSTLELGYIGLAFSITYGLGKTLLGYFVDGRNTKRIISFLLILSAITVLIMGFV
LSYFGSVMGLLIVLWGLNGVFQSVGGPASYSTISRWAPRTKRGRYLGFWNTSHNIGGAIA
GGVALWGANVFFHGNVIGMFIFPSVIALLIGIATLFIGKDDPEELGWNRAEEIWEEPVDK
ENIDSQGMTKWEIFKKYILGNPVIWILCVSNVFVYIVRIGIDNWAPLYVSEHLHFSKGDA
VNTIFYFEIGALVASLLWGYVSDLLKGRRAIVAIGCMFMITFVVLFYTNATSVMMVNISL
FALGALIFGPQLLIGVSLTGFVPKNAISVANGMTGSFAYLFGDSMAKVGLAAIADPTRNG
LNIFGYTLSGWTDVFIVFYVALFLGMILLGIVAFYEEKKIRSLKI
103.
MTKKKNILKAIGIYSFIAMMFVIILYPLLWTFGISLNPGTNLYGAKMIPDNATFKNYAFL
LFDDSSQYLTWYKNTLIVASANALFSVIFVTLTAYAFSRYRFVGRKYGLITFLILQMFPV
LMAMVAIYILLNTIGLLDSLFGLTLVYIGGSIPMNAFLVKGYFDTIPKELDESAKIDGAG
HMRIFLQIMLPLAKPILAVVALFNFMGPFMDFILPKILLRSPEKFTLAVGLFNFINDKYA
NNFTVFAAGAIMIAVPIAIVFLFLQRYLVSGLTTGATKG
104.
MMENSTTEARNEATMHLDEMTVEEALITMNKEDQQVPLAVRKAIPQLTKVIKKTIAQYKK
GGRLIYIGAGTSGRLGVLDAAECVPTFNTDPHEIIGIIAGGQHAMTMAVEGAEDHKKLAE
EDLKNIDLTSKDVVIGIAASGKTPYVIGGLTFANTIGATTVSISCNEHAVISEIAQYPVE
VKVGPEVLTGSTRLKSGTAQKLILNMISTITMVGVGKVYDNLMIDVKATNQKLIDRSVRI
IQEICAITYDEAMALYQVSEHDVKVATVMGMCGISKEEATRRLLNNGDIVKRAIRDRQP
105.
LQYIIRYIMMTLQIHTGGINLKKKNIYSIRKLGVGIASVTLGTLLISGGVTPAANAAQHD
EAQQNAFYQVLNMPNLNADQRNGFIQSLKDDPSQSANVLGEAQKLNDSQAPKADAQQNNF
NKDQQSAFYEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNESQAPKADNNFNK
EQQNAFYEILNMPNLNEEQRNGFIQSLKDDPSQSANLLSEAKKLNESQAPKADNKFNKEQ
QNAFYEILHLPNLNEEQRNGFIQSLKDDPSQSANLLAEAKKLNDAQAPKADNKFNKEQQN
AFYEILHLPNLTEEQRNGFIQSLKDDPSVSKEILAEAKKLNDAQAPKEEDNNKPGKEDNN
KPGKEDNNKPGKEDNNKPGKEDGNKPGKEDNKKPGKEDGNKPGKEDNKKPGKEDGNKPGK
EDGNKPGKEDGNGVHVVKPGDTVNDIAKANGTTADKIAADNKLADKNMIKPGQELVVDKK
QPANHADANKAQALPETGEENPFIGTTVFGGLSLALGAALLAGRRREL
106.
MDKKSEKRGIKMTVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYR
ILKTMYVGGGTPTALSINQLERLLKAIRDTFTITGEYTFEANPDELTKEKVQLLEKYGVK
RISMGVQTFKPELLSVLGRTHNTEDIYTSVLNAKNAGIKSISLDLMYHLPKQTIEDFEQS
LDLALDMDIQHISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQ
YEISNFALDGHESEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKA
ILVSNKPSLTERMEEEMFLGLRLNEGVSSSRFKKKFDQSIESVFGQTINNLKEKELIVEK
NDVIALTNRGKVIGNEVFEAFLIND
107.
atgaatgtattagtaattggtgctggtggacgagaacatgcacttgcatataaacttaat
caatcgaatctagttaaacaagtgtttgtcattccaggtaatgaggcaatgacacctata
gctgaagtacacactgaaatttcagaacctgatcatcaagcgatactagattttgctaaa
cggcaaaatgttgattgggtagttataggtccagaacagccgctaattgatggattagca
gacattttacgagcgaatggtttcaaagtgtttggtccaaataagcaagcagctcaaatc
gaaggctcaaaattatttgctaaaaagataatggaaaaatataatattccaactgctgat
tataaagaagttgagcgaaaaaaggatgctttaacatatattgaaaactgtgaattgccc
gttgttgtcaagaaagatgggttagctgctgggaaaggcgttattattgcagatactatt
gaagcagccagaagtgctattgagattatgtatggtgatgaagaagaaggtactgttgta
tttgaaacgtttttagaaggtgaagagttctcgctaatgacatttgttaatggtgattta
gcagtacctttcgactgtattgcacaagatcataaacgcgcatttgatcatgatgaagga
ccaaatactggtggtatgggggcttattgtccagtaccacatattagtgacgatgtttta
aaacttacaaatgaaacaattgcacaacccattgcaaaggcaatgcttaatgaaggttat
caattcttcggtgtattatacattggtgctattttaactaaagatggtccaaaagtaata
gaatttaatgcccgttttggtgatcctgaagctcaagtattattaagtcgcatggaaagt
gatttaatgcagcatattattgatttagatgaaggaaaacgtactgaattcaaatggaaa
aatgaatctattgtaggggtcatgttggcatcaaaaggatatcctgatgcatatgaaaaa
gggcataaagtaagtggctttgatttaaatgaaaactattttgttagtggattaaagaag
caaggtgatacctttgttacttcaggtggtagagttatacttgccatcggaaaaggtgac
aatgtacaagatgcacagcgagacgcatacaaaaaagtatcacaaatacaaagtgaccat
ttattctatcgtcatgacattgcgaataaagcactacaacttaaa
108.
MNVLVIGAGGREHALAYKLNQSNLVKQVFVIPGNEAMTPIAEVHTEISEPDHQAILDFAK
RQNVDWVVIGPEQPLIDGLADILRANGFKVFGPNKQAAQIEGSKLFAKKIMEKYNIPTAD
YKEVERKKDALTYIENCELPVVVKKDGLAAGKGVIIADTIEAARSAIEIMYGDEEEGTVV
FETFLEGEEFSLMTFVNGDLAVPFDCIAQDHKRAFDHDEGPNTGGMGAYCPVPHISDDVL
KLTNETIAQPIAKAMLNEGYQFFGVLYIGAILTKDGPKVIEFNARFGDPEAQVLLSRMES
DLMQHIIDLDEGKRTEFKWKNESIVGVMLASKGYPDAYEKGHKVSGFDLNENYFVSGLKK
QGDTFVTSGGRVILAIGKGDNVQDAQRDAYKKVSQIQSDHLFYRHDIANKALQLK
109.
atgcaaccacatttaatatgtctagacttagacggaacattattaaacgataacaaagaa
atttcatcatatactaaacaagtattaaatgaattacaacaacgtggacaccaaattatg
attgcgactggcagaccttatcgtgcaagtcaaatgtattatcatgaattaaatttaacg
acaccaattgttaattttaatggcgcttacgtacatcaccctaaagataaaaacttcaaa
acttgccatgaaattttagatttaggcatcgcacaaaacattattcaaggattacaacaa
tatcaagtatcgaatattatagcagaagtgaaagattatgttttcattaacaatcatgat
ccaagattatttgaaggtttttcaatgggtaatccaagaattcaaactggtaatttactt
gtccacttgaaagaatcccctacctcaattttaattgaagccgaagaaagtaaaatacct
gaaatcaaaaatatgcttactcatttttatgccgatcatattgagcatcgacgctggggc
gcaccattccctgtcattgaaattgtaaaacttggtattaataaagcaagaggcattgag
caagttagacaatttttaaatattgaccgaaataatattattgcattcggtgatgaagat
aatgatattgaaatgattgagtacgcgcgtcacggtgttgctatggaaaatggtttgcaa
gaacttaaagatgtagcgaacaatattacattcaacaataatgaagatggcattggtcga
tatttgaatgatttctttaatttaaatattagatattactgt
110.
MQPHLICLDLDGTLLNDNKEISSYTKQVLNELQQRGHQIMIATGRPYRASQMYYHELNLT
TPIVNFNGAYVHHPKDKNFKTCHEILDLGIAQNIIQGLQQYQVSNIIAEVKDYVFINNHD
PRLFEGFSMGNPRIQTGNLLVHLKESPTSILIEAEESKIPEIKNMLTHFYADHIEHRRWG
APFPVIEIVKLGINKARGIEQVRQFLNIDRNNIIAFGDEDNDIEMIEYARHGVAMENGLQ
ELKDVANNITFNNNEDGIGRYLNDFFNLNIRYYC
111.
gtgaaaccaatggctaagtctaatagtaaagacatcgttttaattggagccggtgtactt
agcacaacatttggttcaatgttaaaagaaattgagccagactggaatatccacgtttac
gaacgcttggatcgtcctgcaatcgaaagttcaaacgaaagaaataatgctggtacgggt
catgcagcattatgtgagttgaactacacagttttacaacctgatggttctatcgacatc
gaaaaagcgaaagtgattaacgaagagtttgagatttcaaaacaattctggggtcactta
gtgaaaagcggtagcatcgagaacccaagagaatttatcaatccattaccacacatcagt
tatgttagaggtaaaaacaatgttaaattcttaaaagatcgttacgaagcgatgaaagct
ttccctatgttcgataatatcgaatatactgaagacatcgaagtaatgaaaaaatggatt
ccattgatgatgaaaggccgtgaagataaccctggtatcatggcggcaagtaaaattgac
gaaggtacagatgtaaacttcggtgaattaacacgtaaaatggctaaaagcattgaagca
catccaaatgctacagtgcaatttaaccatgaagttgttgattttgaacaattatcaaat
ggtcaatgggaagttactgttaaaaatcgcctaactggtgagaaattcaaacaagtaact
gactacgtattcatcggtgctggcggtggagcaattccattattacaaaaaacaggtatc
cctgaaagtaaacatttgggtggattccctatcagtggtcaattcttagcttgtacaaac
ccacaagttattgaacaacacgatgccaaagtttatggtaaagagccacctggtacacca
ccaatgactgtacctcatttagatacgcgttacattgatggtcaaagaacattattattt
ggaccatttgctaatgttggacctaaattcttgaaaaatggttctaacttagatttattc
aagtctgttaaaacatacaacattacaactttattagcagcagcagttaaaaacttacct
ttaattaaatactcatttgaccaagtaattatgacaaaagaaggttgtatgaaccactta
cgtactttctatccagaagcacgtaatgaagattggcaattatacactgctggtaaacgt
gtacaagttatcaaagatacacctgaacacggtaaaggattcatccaattcggtacagaa
gtggttaactcacaagaccacactgtaattgcattattaggtgaatcaccaggggcttca
acttcagtttcagttgcgttagaagtattagaacgtaacttccctgaatacaaaactgaa
tgggcacctaaaattaagaaaatgattccatcatacggtgaatcattaattgaagacgaa
aaattaatgagaaaaatccgtaaacaaacttcaaaagacttagaattaggttactacgaa
aac
112.
MKPMAKSNSKDIVLIGAGVLSTTFGSMLKEIEPDWNIHVYERLDRPAIESSNERNNAGTG
HAALCELNYTVLQPDGSIDIEKAKVINEEFEISKQFWGHLVKSGSIENPREFINPLPHIS
YVRGKNNVKFLKDRYEAMKAFPMFDNIEYTEDIEVMKKWIPLMMKGREDNPGIMAASKID
EGTDVNFGELTRKMAKSIEAHPNATVQFNHEVVDFEQLSNGQWEVTVKNRLTGEKFKQVT
DYVFIGAGGGAIPLLQKTGIPESKHLGGFPISGQFLACTNPQVIEQHDAKVYGKEPPGTP
PMTVPHLDTRYIDGQRTLLFGPFANVGPKFLKNGSNLDLFKSVKTYNITTLLAAAVKNLP
LIKYSFDQVIMTKEGCMNHLRTFYPEARNEDWQLYTAGKRVQVIKDTPEHGKGFIQFGTE
VVNSQDHTVIALLGESPGASTSVSVALEVLERNFPEYKTEWAPKIKKMIPSYGESLIEDE
KLMRKIRKQTSKDLELGYYEN
113.
atgctagaggcacaattttttactgatactggacaacatagagataagaatgaagatgcg
ggtggtattttttataatcaaactaatcaacaacttttagttctgtgtgatggtatgggt
ggccataaagcaggagaagttgcaagtaaatttgttacagatgagttgaaatcccgtttt
gaagcggaaaatcttatagaacaacatcaagctgaaaattggttgcgtaataatataaaa
gatataaattttcagttatatcactatgcacaagaaaatgcagaatataaaggtatgggt
acaacatgtgtttgtgcacttgtttttgaaaaatcagttgtgatagcaaatgtcggtgat
tctagagcctatgttattaatagtcgacaaattgaacaaattactagtgatcactcattt
gttaatcatcttgttttaacgggtcaaattacgccggaagaagcatttacacatccacaa
cgtaatattattacgaaggtgatgggcacagataaacgtgtgagtccagatttgtttatt
aagcgattaaatttttatgattatttattattaaattcagatggattaactgattatgtt
aaagacaatgaaattaagcgtttgttagtaaaagaaggtacaatagaagatcatggtgat
caattaatgcaattggcattagataaccattcgaaagataacgttactttcatactcgcg
gctattgaaggtgataaagta
114.
matdtghrdkndaggyntnvcdgmgghkagvaskvtdksranhanwrnnkdnyhyanayk
gmgttcvcavksvvanvgdsrayvnsrtsdhsvnhvtgtathrntkvmgtdkrvsdkrny
dynsdgtdyvkdnkrvkgtdhgdmadnhskdnvtaagdkv
115.
atggcaaaagaaaaattcgatcgttctaaagaacatgccaatatcggtactatcggtcac
gttgaccatggtaaaacaacattaacagcagcaatcgctactgtattagcaaaaaatggt
gactcagttgcacaatcatatgacatgattgacaacgctccagaagaaaaagaacgtggt
atcacaatcaatacttctcacattgagtaccaaactgacaaacgtcactacgctcacgtt
gactgcccaggacacgctgactacgttaaaaacatgatcactggtgctgctcaaatggac
ggcggtatcttagtagtatctgctgctgacggtccaatgccacaaactcgtgaacacatt
cttttatcacgtaacgttggtgtaccagcattagtagtattcttaaacaaagttgacatg
gttgacgatgaagaattattagaattagtagaaatggaagttcgtgacttattaagcgaa
tatgacttcccaggtgacgatgtacctgtaatcgctggttcagcattaaaagctttagaa
ggcgatgctcaatacgaagaaaaaatcttagaattaatggaagctgtagatacttacatt
ccaactccagaacgtgattctgacaaaccattcatgatgccagttgaggacgtattctca
atcactggtcgtggtactgttgctacaggccgtgttgaacgtggtcaaatcaaagttggt
gaagaagttgaaatcatcggtttacatgacacatctaaaacaactgttacaggtgttgaa
atgttccgtaaattattagactacgctgaagctggtgacaacattggtgcattattacgt
ggtgttgctcgtgaagacgtacaacgtggtcaagtattagctgctcctggttcaattaca
ccacatactgaattcaaagcagaagtatacgtattatcaaaagacgaaggtggacgtcac
actccattcttctcaaactatcgtccacaattctatttccgtactactgacgtaactggt
gttgttcacttaccagaaggtactgaaatggtaatgcctggtgataacgttgaaatgaca
gtagaattaatcgctccaatcgcgattgaagacggtactcgtttctcaatccgtgaaggt
ggacgtactgtaggatcaggcgttgttactgaaatcattaaa
116.
MAKEKFDRSKEHANIGTIGHVDHGKTTLTAAIATVLAKNGDSVAQSYDMIDNAPEEKERG
ITINTSHIEYQTDKRHYAHVDCPGHADYVKNMITGAAQMDGGILVVSAADGPMPQTREHI
LLSRNVGVPALVVFLNKVDMVDDEELLELVEMEVRDLLSEYDFPGDDVPVIAGSALKALE
GDAQYEEKILELMEAVDTYIPTPERDSDKPFMMPVEDVFSITGRGTVATGRVERGQIKVG
EEVEIIGLHDTSKTTVTGVEMFRKLLDYAEAGDNIGALLRGVAREEIQRGQVLAAPGSIT
PHTEFKAEVYVLSKDEGGRHTPFFSNYRPQFYFRTTDVTGVVHLPEGTEMVMPGDNVEMT
VELIAPIAIDEGTRFSIREGGRTVGSGVVTEITE
117.
atgactaagagtgctttagtaacaggtgcatcaagaggaattggacgtagtattgcgtta
caattagcagaagaaggatataatgtagcagtaaactatgcaggcagcaaagagaaagct
gaagcagtagtcgaagaaatcaaagctaaaggtgttgaaagttttgcgattcaagcaaat
gttgccgatgcatgaaaatgactaagagtgctttagtaacaggtgcatcaagaggaattg
gacgtagtattgcgttacaattagcagaagaaggatataatgtagcagtaaactatgcag
gcagcaaagagaaagctgaagcagtagtcgaagaaatcaaagctaaaggtgttgaaagtt
ttgcgattcaagcaaatgttgccgatgctgatgaagttaaagcaatgattaaagaagtag
ttagccaatttggttctttagatgttttagtaaataatgcaggtattactcgcgataatt
tattaatgcgtatgaaagaacaagagtgggatgatgttattgacacaaacttaaaaggtg
tatttaactgtatccaaaaagcaacaccacaaatgttaagacaacgtagtggtgctatca
tcaatttatcaagtgttgttggagcagtaggtaatccgggacaagcaaactatgttgcaa
caaaagcaggtgttattggtttaactaaatctgcggcgcgtgaattagcatctcgtggta
tcactgtaaatgcagttgcacctggttttattgtttctgatatgacagatgctttaagtg
atgagcttaaagaacaaatgttgactcaaattccgttagcacgttttggtcaagacacag
atattgctaatacagtagcgttcttagcatcagacaaagcaaaatatattacaggtcaaa
caatccatgtaaatggtggaatgtacatg
118.
MTKSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVESFAIQAN
VADADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKGVFNCIQ
KATPQMLRQRSGAIINLSSVVGAVGNPGQANYVATKAGVIGLTKSAARELASRGITVNAV
APGFIVSDMTDALSDELKEQMLTQIPLARFGQDTDIANTVAFLASDKAKYITGQTIHVNG
GMYM
119.
atgaaaatttctactaaagggagatatggacttacattgatgatttctcttgctaaaaaa
gaggggcaaggatgtatatcattaaagtcaattgctgaagaaaataatttgagtgattta
tatttagaacagcttgtaggtcctttaagaaatgcggggttaattcgaagtgtacgcggt
gctaaaggtggataccaattaagagtgccagcggaagaaatctcagcaggggatattata
agactgttagaaggtccaattacatttgttgaaagtattgaatcagaaccacctgcgcaa
aaacaactatggattcgcatgagagatgcagtgagagatgttttagataatacaacattg
aaatatttagcggaatatgtagatacaagtgaagatttagacggatacatgttttatatt
120.
MLKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQLVSPLRNAGLVKSIR
GAYGGYVLGSEPDAITAGDIIRVLEGPISLLKCWKMRSLPSVSSGFASGML
121.
gtggcatttgaatttagattacccgatatcggggaaggtatccacgaaggtgaaattgta
aaatggtttgttaaagctggagatactattgaagaagacgatgttttagctgaggtacaa
aacgataaatcagtagtagaaatcccatcaccagtatctggtactgtagaagaagttatg
gtagaagaaggtacagtagctgtagttggtgacgttattgttaaaatcgatgcacctgat
gcagaagatatgcaatttaaaggtcatgatgatgattcatcatctaaagaagaacctgcg
aaagaggaagcgccagcagagcaagcacctgtagctactcaaactgaagaagtagatgaa
aacagaactgttaaagcaatgccttcagtacgtaaatacgcacgtgaaaaaggtgttaac
attaaagcagtttctggatctggtaaaaatggtcgtattacaaaagaagatgtagatgca
tacttaaatggtggtgcaccaacagcttcaaatgaatcagctgcttcagctacaagtgaa
gaagttgctgaaactcctgcagcacctgcagcagtaacattagaaggcgacttcccagaa
acaactgaaaaaatccctgctatgcgtagagcaattgcgaaagcaatggttaactctaag
catactgcacctcatgtaacattaatggatgaaattgatgttcaagcattatgggatcac
cgtaagaaatttaaagaaatcgcagctgaacaaggtactaagttaacattcttaccttat
gttgttaaagcacttgtttctgcattgaaaaaatacccagcacttaacacttcattcaat
gaagaagctggtgaaatcgttcataaacattactggaatatcggtattgcagcagacact
gatagaggattattagtacctgttgttaaacatgctgatcgtaagtctattttccaaatt
tcagatgaaattaatgaattagctgttaaagcacgtgatggtaaattaacagccgatgaa
atgaaaggtgctacatgcacaatcagtaatatcggttcagctggtggacaatggttcact
ccagttatcaatcacccagaagtagcaatcttaggaattggccgtattgctcaaaaacct
atcgttaaagatggagaaattgttgcagcaccagtattagcattatcattaagctttgac
cacagacaaattgatggtgcaactggccaaaatgcaatgaatcacattaaacgtttatta
aataatccagaattattattaatggagggg
122.
MAFEFRLPDIGEGIHEGEIVKWFVKAGDTIEEDDVLAEVQNDKSVVEIPSPVSGTVEEVM
VEEGTVAVVGDVIVKIDAPDAEDMQFKGHDDDSSSKEEPAKEEAPAEQAPVATQTEEVDE
NRTVKAMPSVRKYAREKGVNIKAVSGSGKNGRITKEDVDAYLNGGAPTASNESAASATSE
EVAETPAAPAAVTLEGDFPETTEKIPAMRRAIAKAMVNSKHTAPHVTLMDEIDVQALWDH
RKKFKEIAAEQGTKLTFLPYVVKALVSALKKYPALNTSFNEEAGEIVHKHYWNIGIAADT
DRGLLVPVVKHADRKSIFQISDEINELAVKARDGKLTADEMKGATCTISNIGSAGGQWFT
PVINHPEVAILGIGRIAQKPIVKDGEIVAAPVLALSLSFDHRQIDGATGQNAMNHIKRLL
123.
atgctaaacagagaaaataaaacggcaataacaaggaaaggcatggtatccaatcgatta
aataaattttcgattagaaagtacacagtgggaacagcatcaattttagtaggtacaaca
ttaatttttggtctggggaaccaagaagcaaaggctgcagaaagtactaataaagaattg
aacgaagcgacaacttcagcaagtgataatcaatcgagtgataaagttgatatgcagcaa
ctaaatcaagaagacaatactaaaaatgataatcaaaaagaaatggtatcatctcaaggt
aatgaaacgacttcaaatgggaataaattaatagaaaaagaaagtgtacaatctaccact
ggaaataaagttgaagtttcaactgccaaatcagatgagcaagcttcaccaaaatctacg
aatgaagatttaaacactaaacaaactataagtaatcaagaagcgttacaacctgatttg
caagagaataaatcagtggtaaatgttcaaccaactaatgaggaaaacaaaaaggtagat
gccaaaactgaatcaactacattaaatgttaaaagtgatgctatcaagagtaatgatgaa
actcttgttgataacaatagtaattcaaataatgaaaataatgcagatatcattttgcca
aaaagtacagcacctaaacgtttgaatacaagaatgcgtatagcagcagtacagccatca
tcaacagaggctaaaaatgttaatgatttaatcacatcaaatacaacattaactgtcgtt
gatgcagataaaaacaataaaatcgtaccagcccaagattatttatcattaaaatcacaa
attacagttgatgacaaagttaaatcaggtgattatttcacaattaaatactcagataca
gtacaagtatatggattgaatccggaagatattaaaaatattggtgatattaaagatcca
aataatggtgaaacaattgcgactgcaaaacatgatactgcaaataatttaattacatat
acatttacagattatgttgatcgatttaattctgtacaaatgggaattaattattcaatt
tatatggatgctgatacaattcctgttagtaaaaacgatgttgagtttaatgttacgata
ggtaatactacaacaaaaacaactgctaacattcaatatccagattatgttgtaaatgag
aaaaattcaattggatcagcgttcactgaaacagtttcacatgttggaaataaagaaaat
ccagggtactataaacaaacgatttatgtaaatccatcggaaaattctttaacaaatgcc
aaactaaaagttcaagcttaccactcaagttatcctaataatatcgggcaaataaataaa
gatgtaacagatataaaaatatatcaagttcctaaaggttatacattaaataaaggatac
gatgtgaatactaaagagcttacagatgtaacaaatcaatacttgcagaaaattacatat
ggcgacaacaatagcgctgttattgattttggaaatgcagattctgcttatgttgtaatg
gttaatacaaaattccaatatacaaatagcgaaagcccaacacttgttcaaatggctact
ttatcttcaacaggtaataaatccgtttctactggcaatgctttaggatttactaataac
caaagtggcggagctggtcaagaagtatataaaattggtaactacgtatgggaagatact
aataaaaacggtgttcaagaattaggagaaaaaggcgttggcaatgtaactgtaactgta
tttgataataatacaaatacaaaagtaggagaagcagttactaaagaagatgggtcatac
ttgattccaaacttacctaatggagattaccgtgtagaattttcaaacttaccaaaaggt
tatgaagtaaccccttcaaaacaaggtaataacgaagaattagattcaaacggcttatct
tcagttattacagttaatggcaaagataacttatctgcagacttaggtatttacaaacct
aaatacaacttaggtgactatgtctgggaagatacaaataaaaatggtatccaagaccaa
gatgaaaaaggtatatctggcgtaacggtaacattaaaagatgaaaacggtaacgtgtta
aaaacagttacaacagacgctgatggcaaatataaatttactgatttagataatggtaat
tataaagttgaatttactacaccagaaggctatacaccgactacagtaacatctggtagc
gacattgaaaaagactctaatggtttaacaacaacaggtgttattaatggtgctgataac
atgacattagatagtggattctacaaaacaccaaaatataatttaggtaattatgtatgg
gaagatacaaataaagatggtaagcaggattcaactgaaaaaggtatttcaggcgtaaca
gttacattgaaaaatgaaaacggtgaagttttacaaacaactaaaacagataaagatggt
aaatatcaatttactggattagaaaatggaacttataaagttgaattcgaaacaccatca
ggttacacaccaacacaagtaggttcaggaactgatgaaggtatagattcaaatggtaca
tcaacaacaggtgtcattaaagataaagataacgatactattgactctggtttctacaaa
ccgacttacaacttaggtgactatgtatgggaagatacaaataaaaacggtgttcaagat
aaagatgaaaagggcatttcaggtgtaacagttacgttaaaagatgaaaacgacaaagtt
ttaaaaacagttacaacagatgaaaatggtaaatatcaattcactgatttaaacaatgga
acttataaagttgaattcgagacaccatcaggttatacaccaacttcagtaacttctgga
aatgatactgaaaaagattctaatggtttaacaacaacaggtgtcattaaagatgcagat
aacatgacattagacagtggtttctataaaacaccaaaatatagtttaggtgattatgtt
tggtacgacagtaataaagacggcaaacaagattcaactgaaaaaggtatcaaagatgtt
aaagttactttattaaatgaaaaaggcgaagtaattggaacaactaaaacagatgaaaat
ggtaaatactgctttgataatttagatagcggtaaatacaaagttatttttgaaaagcct
gctggcttaacacaaacaggtacaaatacaactgaagatgataaagatgcagatggtggc
gaagttgacgtaacaattacggatcatgatgatttcacacttgataatggctactacgaa
gaagaaacatcagatagcgactcagattcggacagcgactcagattcagacagagactca
gactcagatagtgattcagactcggatagcgattcagattcagacagcgattcagattca
gatagcgattcagattcagacagagactcagatagtgattcagactcagatagcgactca
gattcagacagcgactcagattcagacagcgactcagactcagatagtgattcagactca
gatagcgactcagattcagacagcgactcagactcagacagcgactcagactcagatagt
gactcagattcagatagcgactcagattcggacagcgattcagactcagatagcgactca
gattcagatagcgattcggactcagatagcgactcagattcagatagtgattcagactca
gatagcgactcagattcagacagcgactcagattcggatagcgactcagattcagacagc
gactcagactcggatagtgattcagactcagatagcgactcagactcagatagcgattca
gattcagatagcgactcagactcagacagcgattcagactcagacagcgactcagactca
gatgcaggtaagcacacacctgttaaaccaatgagtactactaaagaccatcacaataaa
gcaaaagcattaccagaaacaggtaatgaaaatagcggctcaaataacgcaacgttattt
ggcggattattcgcagcattaggatcattattgttattcggtcgtcgtaaaaaacaaaat
aaa
124.
MLNRENKTAITRKGMVSNRLNKFSIRKYTVGTASILVGTTLIFGLGNQEAKAAESTNKEL
NEATTSASDNQSSDKVDMQQLNQEDNTKNDNQKEMVSSQGNETTSNGNKLIEKESVQSTT
GNKVEVSTAKSDEQASPKSTNEDLNTKQTISNQEALQPDLQENKSVVNVQPTNEENKKVD
AKTESTTLNVKSDAIKSNDETLVDNNSNSNNENNADIILPKSTAPKRLNTRMRIAAVQPS
STEAKNVNDLITSNTTLTVVDADKNNKIVPAQDYLSLKSQITVDDKVKSGDYFTIKYSDT
VQVYGLNPEDIKNIGDIKDPNNGETIATAKHDTANNLITYTFTDYVDRFNSVQMGINYSI
YMDADTIPVSKNDVEFNVTIGNTTTKTTANIQYPDYVVNEKNSIGSAFTETVSHVGNKEN
PGYYKQTIYVNPSENSLTNAKLKVQAYHSSYPNNIGQINKDVTDIKIYQVPKGYTLNKGY
DVNTKELTDVTNQYLQKITYGDNNSAVIDFGNADSAYVVMVNTKFQYTNSESPTLVQMAT
LSSTGNKSVSTGNALGFTNNQSGGAGQEVYKIGNYVWEDTNKNGVQELGEKGVGNVTVTV
FDNNTNTKVGEAVTKEDGSYLIPNLPNGDYRVEFSNLPKGYEVTPSKQGNNEELDSNGLS
SVITVNGKDNLSADLGIYKPKYNLGDYVWEDTNKNGIQDQDEKGISGVTVTLKDENGNVL
KTVTTDADGKYKFTDLDNGNYKVEFTTPEGYTPTTVTSGSDIEKDSNGLTTTGVINGADN
MTLDSGFYKTPKYNLGNYVWEDTNKDGKQDSTEKGISGVTVTLKNENGEVLQTTKTDKDG
KYQFTGLENGTYKVEFETPSGYTPTQVGSGTDEGIDSNGTSTTGVIKDKDNDTIDSGFYK
PTYNLGDYVWEDTNKNGVQDKDEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNG
TYKVEFETPSGYTPTSVTSGNDTEKDSNGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYV
WYDSNKDGKQDSTEKGIKDVKVTLLNEKGEVIGTTKTDENGKYCFDNLDSGKYKVIFEKP
AGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYEEETSDSDSDSDSDSDSDRDS
DSDSDSDSDSDSDSDSDSDSDSDSDSDRDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS
DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHT
PVKPMSTTKDHHNKAKALPETGNENSGSNNATLFGGLFAALGSLLLFGRRKKQNK
125.
ttggcaggtcaagttgtccaatatggaagacatcgtaaacgtagaaactacgcgagaatt
tcagaagtattagaattaccaaacttaatagaaattcaaactaaatcttacgagtggttc
ctaagagaaggtttaatcgaaatgtttagagacatttctccaattgaagattttactggt
aatttgtcattagagtttgtggattaccgtttaggagaaccaaaatatgatttagaagaa
tctaaaaaccgtgacgctacttatgctgcacctcttcgtgtaaaagtgcgtctaatcatt
aaagaaacaggagaagttaaagaacaagaagtctttatgggtgatttcccattaatgact
gatacaggtacgttcgttatcaatggtgcagaacgtgtaatcgtatctcaattagttcgt
tcaccatccgtttatttcaatgaaaaaatcgacaaaaatggtcgtgaaaactatgatgca
acaattattccaaaccgtggtgcatggttagaatatgaaacagatgctaaagatgttgta
tacgtacgtattgatagaacacgtaaactaccattaacagtattgttacgtgcattaggt
ttctcaagcgaccaagaaattgttgaccttttaggtgacaatgaatatttacgtaatact
ttagagaaagacggcactgaaaacactgaacaagcgttattagaaatctatgaacgttta
cgtccaggtgaaccaccaactgttgaaaatgctaaaagtctattgtattcacgtttcttt
gatccaaaacgctatgacttagcaagcgtgggtcgttataaaacaaacaaaaaattacat
ttaaaacatcgtttatttaatcaaaaattagctgagccaattgtaaatactgaaactggt
gaaattgtagttgaagaaggtacagtgcttgatcgtcgtaaaatcgacgaaatcatggat
gtacttgaatcaaatgcaaacagcgaagtgtttgaattgcatggtagcgttatagacgag
ccagtagaaattcaatcaattaaagtatatgttcctaacgatgatgaaggtcgtacgaca
actgtaattggtaatgctttccctgactcagaagttaaatgcattacaccagcagatatc
attgcttcaatgagttacttctttaacttattaagcggtattggatatacagatgatatt
gaccatttaggtaaccgtcgtttacgttctgtaggtgaattactacaaaaccaattccgt
atcggtttatcaagaatggaaagagttgtacgtgaaagaatgtcaattcaagatactgag
tctatcacacctcaacaattaattaatattcgacctgttattgcatctattaaagaattc
tttggtagctctcaattatcacaattcatggaccaagcaaacccattagctgagttaacg
cataaacgtcgtctatcagcattaggacctggtggtttaacacgtgaacgtgctcaaatg
gaagtacgtgacgttcactactctcactatggccgtatgtgtccaattgaaacacctgag
ggaccaaacattggattgattaactcattatcaagttatgcacgtgtaaatgaattcggc
tttattgaaacaccatatcgtaaagttgatttagatacacatgctatcactgatcaaatt
gactatttaacagctgacgaagaagatagctatgttgtagcacaagcaaactctaaatta
gatgaaaatggtcgtttcatggatgatgaagttgtatgtcgtttccgtggtaacaataca
gttatggctaaagaaaaaatggattatatggatgtatcgccgaagcaagttgtttcagca
gcgacagcatgtattccattcttagaaaatgatgactcaaaccgtgcattgatgggtgcg
aacatgcaacgtcaagcagtgcctttgatgaatccagaagcaccatttgttggtacaggt
atggaacacgttgcagcacgtgattctggtgcggctattacagctaagcacagaggtcgt
gttgaacatgttgaatctaatgaaattcttgttcgtcgtctagttgaagagaacggcgtt
gagcatgaaggtgaattagatcgctatccattagctaaatttaaacgttcaaactcaggt
acatgttacaaccaacgtccaatcgttgcagttggagatgttgttgagtataacgagatt
ttagcagatggaccatctatggaattaggagaaatggcattaggtagaaacgtagtagtt
ggtttcatgacttgggacggttacaactatgaggatgccgttatcatgagtgaaagactt
gtgaaagatgacgtgtatacttctattcatattgaagagtatgaatcagaagtacgtgat
actaagttaggacctgaagaaatcacaagagatattcctaatgtttctgaaagtgcactt
aagaacttagacgatcgtggtatcgtttatattggtgcagaagtaaaagatggagatatt
ttagttggtaaagtaacgcctaaaggtgtaactgagttaactgccgaagaaagattgtta
catgcaatctttggtgaaaaagcacgtgaagttagagatactttattacgtgtacctcac
ggcgctggcggtatcgttcttgatgtaaaagtattcaatcgtgaagaaggcgacgataca
ttatcacctggtgtaaaccaattagtacgtgtatatatcgttcaaaaacgtaaaattcat
gttggtgataagatgtgtggtcgacatggtaacaaaggtgtcatttctaagattgttcct
gaagaagatatgccttacttaccagatggacgtccgatcgatatcatgttaaatcctctt
ggtgtaccatctcgtatgaacatcggacaagtattagagctacacttaggtatggctgct
aaaaatcttggtattcacgttgcatcaccagtatttgacggtgcaaacgatgacgatgta
tggtcaacaattgaagaagctggtatggctcgtgatggtaaaactgtactttatgatgga
cgtacaggtgaaccattcgataaccgtatttcagtaggtgtaatgtacatgttgaaactt
gcgcacatggttgatgataaattacatgcgcgttcaacaggaccatattcacttgttaca
caacaaccacttggcggtaaagcgcaattcggtggacaacgttttggtgagatggaggta
tgggcacttgaagcatatggtgctgcatacacattacaagaaatcttaacttacaaatcc
gatgatacagtaggacgtgtgaaaacatacgaggctattgttaaaggtgaaaacatctct
agaccaagtgttccagaatcattccgagtattgatgaaagaattacaaagtttaggttta
gatgtaaaagttatggatgagcaagataatgaaatcgaaatgacagacgttgatgacgat
gatgttgtagaacgcaaagtagatttacaacaaaatgatgctcctgaaacacaaaaagaa
gttactgat
126.
MAGQVVQYGRHRKRRNYARISEVLELPNLIEIQTKSYEWFLREGLIEMFRDISPIEDFTG
NLSLEFVDYRLGEPKYDLEESKNRDATYAAPLRVKVRLIIKETGEVKEQEVFMGDFPLMT
DTGTFVINGAERVIVSQLVRSPSVYFNEKIDKNGRENYDATIIPNRGAWLEYETDAKDVV
YVRIDRTRKLPLTVLLRALGFSSDQEIVDLLGDNEYLRNTLEKDGTENTEQALLEIYERL
RPGEPPTVENAKSLLYSRFFDPKRYDLASVGRYKTNKKLHLKHRLFNQKLAEPIVNTETG
EIVVEEGTVLDRRKIDEIMDVLESNANSEVFELHGSVIDEPVEIQSIKVYVPNDDEGRTT
TVIGNAFPDSEVKCITPADIIASMSYFFNLLSGIGYTDDIDHLGNRRLRSVGELLQNQFR
IGLSRMERVVRERMSIQDTESITPQQLINIRPVIASIKEFFGSSQLSQFMDQANPLAELT
HKRRLSALGPGGLTRERAQMEVRDVHYSHYGRMCPIETPEGPNIGLINSLSSYARVNEFG
FIETPYRKVDLDTHAITDQIDYLTADEEDSYVVAQANSKLDENGRFMDDEVVCRFRGNNT
VMAKEKMDYMDVSPKQVVSAATACIPFLENDDSNRALMGANMQRQAVPLMNPEAPFVGTG
MEHVAARDSGAAITAKHRGRVEHVESNEILVRRLVEENGVEHEGELDRYPLAKFKRSNSG
TCYNQRPIVAVGDVVEYNEILADGPSMELGEMALGRNVVVGFMTWDGYNYEDAVIMSERL
VKDDVYTSIHIEEYESRRQRDTKLGPEEITRDIPNVSESALKNLDDRGIVYIGAEVKDGD
ILVGKVTPKGVTELTAEERLLHAIFGEKAREVRDTSLRVPHGAGGIVLDVKVFNREEGDD
TLSPGVNQLVRVYIVQKRKIHVGDKMCGRHGNKGVISKIVPEEDMPYLPDGRPIDIMLNP
LGVPSRMNIGQVLELHLGMAAKNLGIHVASPVFDGANDDDVWSTIEEAGMARDGKTVLYD
GRTGEPFDNRISVGVMYMLKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEME
VWALEAYGAAYTLQEILTYKSDDTVGRVKTYEAIVKGENISRPSVPESFRVLMKELQSLG
LDVKVMDEQDNEIEMTDVDDDDVVERKVDLQQNDAPETQKSY
127.
atgcttagggcatcgccatatctatcgtatttattcagtaatataaactggaaggagaaa
aaatacatggctagagaattttcattagaaaaaactcgtaatatcggtatcatggctcac
attgatgctggtaaaacgactacgactgaacgtattctttattacactggccgtatccac
aaaattggtgaaacacacgaaggtgcttcacaaatggactggatggagcaagaacaagac
cgtggtattactatcacatctgctgcaacaacagcagcttgggaaggtcaccgtgtaaac
attatcgatacacctggacacgtagacttcactgtagaagttgaacgttcattacgtgta
cttgacggagcagttacagtacttgatgcacaatcaggtgttgaacctcaaactgaaaca
gtttggcgtcaggctacaacttatggtgttccacgtatcgtatttgtaaacaaaatggac
aaattaggtgctaacttcgaatactctgtaagtacattacatgatcgtttacaagctaac
gctgctccaatccaattaccaattggtgcggaagacgaattcgaagcaatcattgactta
gttgaaatgaaatgtttcaaatatacaaatgatttaggtactgaaattgaagaaattgaa
attcctgaagaccacttagatagagctgaagaagctcgtgctagcttaatcgaagcagtt
gcagaaactagcgacgaattaatggaaaaatatcttggtgacgaagaaatttcagtttct
gaattaaaagaagctatccgccaagctactactaacgtagaattctacccagtactttgt
ggtacagctttcaaaaacaaaggtgttcaattaatgcttgacgctgtaattgattactta
ccttcaccactagacgttaaaccaattattggtcaccgtgctagcaaccctgaagaagaa
gtaatcgcgaaagcagacgattcagctgaattcgctgcattagcgttcaaagttatgact
gacccttatgttggtaaattaacattcttccgtgtgtattcaggtacaatgacatctggt
tcatacgttaagaactctactaaaggtaaacgtgaacgtgtaggtcgtttattacaaatg
cacgctaactcacgtcaagaaatcgatactgtatactctggagatatcgctgctgcggta
ggtcttaaagatacaggtactggtgatactttatgtggtgagaaaaatgacattatcttg
gaatcaatggaattcccagagccagttattcacttatcagtagagccaaaatctaaagct
gaccaagataaaatgactcaagctttagttaaattacaagaagaagacccaacattccat
gcacacactgacgaagaaactggacaagttatcatcggtggtatgggtgagcttcactta
gacatcttagtagaccgtatgaagaaagaattcaacgttgaatgtaacgtaggtgctcca
atggtttcatatcgtgaaacattcaaatcatctgcacaagttcaaggtaaattctctcgt
caatctggtggtcgtggtcaatacggtgatgttcacattgaattcacaccaaacgaaaca
ggcgcaggtttcgaattcgaaaacgctatcgttggtggtgtagttcctcgtgaatacatt
ccatcagtagaagctggtcttaaagatgctatggaaaatggtgttttagcaggttatcct
ttaattgatgttaaagctaaattatatgatggttcataccatgatgtcgattcatctgaa
atggccttcaaaattgctgcatcattagcacttaaagaagctgctaaaaaatgtgatcct
gtaatcttagaaccaatgatgaaagtaactattgaaatgcctgaagagtacatgggtgat
atcatgggtgacgtaacatctcgtcgtggacgtgttgatggtatggaacctcgtggtaat
gcacaagttgttaatgcttatgtaccactttcagaaatgttcggttatgcaacatcatta
cgttcaaacactcaaggtcgcggtacttacactatgtacttcgatcactatgctgaagtt
ccaaaatcaatcgctgaagatattatcaagaaaaataaaggtgaa
128.
MAREFSLEKTRNIGIMAHIDAGKTTTTERILYYTGRIHKIGETHEGASQMDWMEQEQDRG
ITITSAATTAAWEGHRVNIIDTPGHVDFTVEVERSLRVLDGAVTVLDAQSGVEPQTETVW
RQATTYGVPRIVFVNKMDKLGANFEYSVSTLHDRLQANAAPIQLPIGAEDEFEAIIDLVE
MKCFKYTNDLGTEIEEIEIPEDHLDRAEEARASLIEAVAETSDELMEKYLGDEEISVSEL
KEAIRQATTNVEFYPVLCGTAFKNKGVQLMLDAVIDYLPSPLDVKPIIGHRASNPEEEVI
AKADDSAEFAALAFKVMTDPYVGKLTFFRVYSGTMTSGSYVKNSTKGKRERVGRLLQMHA
NSRQEIDTVYSGDIAAAVGLKDTGTGDTLCGEKNDIILESMEFPEPVIHLSVEPKSKADQ
DKMTQALVKLQEEDPTFHAHTDEETGQVIIGGMGELHLDILVDRMKKEFNVECNVGAPMV
SYRETFKSSAQVQGKFSRQSGGRGQYGDVHIEFTPNETGAGFEFENAIVGGVVPREYIPS
VEAGLKDAMENGVLAGYPLIDVKAKLYDGSYHDVDSSEMAFKIAASLALKEAAKKCDPVI
LEPMMKVTIEMPEEYMGDIMGDVTSRRGRVDGMEPRGNAQVVNAYVPLSEMFGYATSLRS
NTQGRGTYTMYFDHYAEVPKSIAEDIIKKNKGE
129.
atgactaaaaaagtagcaattattctagcaaacgaatttgaagatatagaatattcaagc
cctaaagaggcattagagaatgcaggctttaatactgtagtgattggagatactgcaaat
agtgaagttgttggtaaacacggtgaaaaagttactgtcgatgtaggcattgcagaagct
aaaccagaagattatgatgcattattaattcctggaggattttcaccagatcatttacgt
ggagatacagaaggtcgatatggcacatttgctaaatactttactaaaaatgatgtacca
acatttgccatttgtcatgggccacaaatactaatagatacagacgatttaaaaggtcgt
acgttaacagcagtattaaatgtacgcaaagatttatcaaatgcaggcgcacatgtagtt
gatgagtcagtagttgtagacaacaatattgtaacaagtcgagtaccagacgatttagat
gattttaatcgagaaatcgttaaacaattacaa
130.
MTKKVAIILANEFEDIEYSSPKEALENAGFNTVVIGDTANSEVVGKHGEKVTVDVGIAEA
KPEDYDALLIPGGFSPDHLRGDTEGRYGTFAKYFTKNDVPTFAICHGPQILIDTDDLKGR
TLTAVLNVRKDLSNAGAHVVDESVVVDNNIVTSRVPDDLDDFNREIVKQLQ
131.
atggctaatcatgaacaaatcattgaagcgattaaagaaatgtcagtattagaattaaac
gacttagtaaaagcaattgaagaagaatttggtgtaactgcagctgctccagtagcagta
gcaggtgcagctggtggcgctgacgctgcagcagaaaaaactgaatttgacgttgagtta
acttcagctggttcatctaaaatcaaagttgttaaagctgttaaagaagcaactggttta
ggattaaaagatgctaaagaattagtagacggagctcctaaagtaatcaaagaagcttta
cctaaagaagaagctgaaaaacttaaagaacaattagaagaagttggagctactgtagaa
ttaaaa
132.
MANHEQIIEAIKEMSVLELNDLVKAIEEEFGVTAAAPVAVAGAAGGADAAAEKTEFDVEL
TSAGSSKIKVVKAVKEATGLGLKDAKELVDGAPKVIKEALPKEEAEKLKEQLEEVGATVE
LK
133.
gtggaattacaattagcaattgatttattaaacaaagaagacgcggctgagttagcaaat
aaagtaaaagattatgtagatatcgtagaaatcggtacgccaatcatttacaacgaaggt
ttaccagcagttaaacatatggcagacaacattagtaatgtaaaagtattagcagacatg
aaaattatggatgcagctgattatgaagttagccaagcaattaaatttggcgcggatgta
attacaatactaggtgttgcagaagatgcatcaattaaagcagctattgaagaagctcat
aaaaataataaacaattactagttgatatgattgctgttcaagatttagaaaaacgtgca
aaagaactagatgaaatgggtgctgattatattgcagtacacactggttatgatttacaa
gcagaagggcaatcaccattagaaagtttaagaaccgttaaatctgttattaaaaattct
aaagttgcagtagcaggtggaattaaaccagatacaattaaagatattgtcgctgaaagt
cctgatcttgttattgttggtggcggaatcgcaaatgcagatgatccagtagaagctgca
aaacaatgtcgcgctgcaatcgaaggtaag
134.
MELQLAIDLLNKEDAAELANKVKDYVDIVEIGTPIIYNEGLPAVKHMADNISNVKVLADM
KIMDAADYEVSQAIKFGADVITILGVAEDASIKAAIEEAHKNNKQLLVDMIAVQDLEKRA
KELDEMGADYIAVHTGYDLQAEGQSPLESLRTVKSVIKNSKVAVAGGIKPDTIKDIVAES
PDLVIVGGGIANADDPVEAAKQCRAAIEGK
135.
atgaaaaaattagtacctttattattagccttattacttctagttgctgcatgtggtact
ggtggtaaacaaagcagtgataagtcaaatggcaaattaaaagtagtaacgacgaattca
attttatatgatatggctaaaaatgttggtggagacaacgtcgatattcatagtattgta
cctgttggtcaagatcctcatgaatatgaagttaaacctaaagatattaaaaagttaact
gacgctgacgttattttatacaacggattaaatttagagactggtaacggttggtttgaa
aaagccttagaacaggctggtaaatcattaaaagataaaaaagttatcgcagtatcaaaa
gatgttaaacctatctatttaaacggtgaagaaggcaacaaagataaacaagatccacac
gcatggttaagtttagataacggtattaaatacgtaaaaacaattcaacaaacatttatc
gataacgacaaaaaacataaagcagattatgaaaagcaaggtaacaaatacattgctcaa
ttggaaaaattaaataatgacagtaaagacaaatttaatgacattccaaaagaacaacgt
gccatgattacaagtgaaggtgccttcaagtacttctcaaaacaatacggtattacacca
ggttatatttgggaaattaacactgaaaaacaaggtacacctgaacaaatgagacaagct
attgagtttgttaaaaagcacaaattaaaacacttattagtagaaacaagtgttgataag
aaagcaatggaaagtttatctgaagaaacgaagaaagatatctttggtgaagtgtacaca
gattcaatcggtaaagaaggcactaaaggtgactcttactacaaaatgatgaaatcaaat
attgaaactgtacacggaagcatgaaa
136.
MKKLVPLLLALLLLVAACGTGGKQSSDKSNGKLKVVTTNSILYDMAKNVGGDNVDIHSIV
PVGQDPHEYEVKPKDIKKLTDADVILYNGLNLETGNGWFEKALEQAGKSLKDKKVIAVSK
DVKPIYLNGEEGNKDKQDPHAWLSLDNGIKYVKTIQQTFIDNDKKHKADYEKQGNKYIAQ
LEKLNNDSKDKFNDIPKEQRAMITSEGAFKYFSKQYGITPGYIWEINTEKQGTPEQMRQA
IEFVKKHKLKHLLVETSVDKKAMESLSEETKKDIFGEVYTDSIGKEGTKGDSYYKMMKSN
IETVHGSMK
137.
atgacaactgatattttgaacatttctgaagaacaacttgttgattattctaaagcccac
aatgaaccttcttggatgacagaattacgtaaaaaagctttgaaattaacagaaacttta
gaaatgccaaaacctgataaaacaaaattaagaaaatgggattttgattcttttaaacaa
cacgatgtaaaaggtgatgtttatcaatctttatcacaattacctgagtcagtaagagaa
attattgacgtagatcattctaaaaacttagtaattcaacataataatacgattgcgtac
acacaagttgatgataatgcatcgaaagatggcgttatcgttgaaggtttagcagacgct
cttatgaaccatagtgatttagtacaaaagtactttatgaaagatgcagtaacagtagat
gaacatcgtatcacagcgctacacacggcattagttaatggtggcgtatttgtttatgtt
cctaaaaatgtagttgtagaacatccagtacaatacgttgtgttgcacgacgacgaaaat
gcaagcttttataaccatgttatcatcgttactgaagaaagcgccgaagtcacatatgtt
gaaaattacttatcaaatgcatctggtgaaggaaatcaattaaatattatttctgaagtg
attgctggtgcaaattcaaatatcacatatggctcagtggactatatggataaaggcttt
acaggtcatatcattcgacgtggtattactgaagcggatgcctcaattaattgggcacta
ggtttaatgaatgagggtagccaaattattgataatacaacaaatttatttggtgatcgt
tcaacaagttcacttaaatcagtagttgtaggtacaggcgaacaaaaaattaatctaaca
tctaaaatcgtacaatatggtaaagaaacagatggttatatccttaaacatggtgttatg
aaagaacatgcatcgtctgtatttaatggtatcggctacattaagcatggtggaactaaa
tcaattgctaatcaggaatcacgtgtattaatgttatctgaacatgctcgtggtgacgcg
aatcctattttattaattgatgaagatgatgtacaagctggtcatgctgcatcagtaggt
cgtgttgatccagatcaactttactatttaatgagtcgtggtatttctcaaagagaagcg
gaacgtcttgttatacatggtttcttagatccagtagtacgtgaattacctatcgaagac
gttaaacgtcaattgagagaagtaattgaacgcaaagtttctaaa
138.
MTTDILNISEEQLVDYSKAHNEPSWMTELRKKALKLTETLEMPKPDKTKLRKWDFDSFKQ
HDVKGDVYQSLSQLPESVREIIDVDHSKNLVIQHNNTIAYTQVDDNASKDGVIVEGLADA
LMNHSDLVQKYFMKDAVTVDEHRITALHTALVNGGVFVYVPKNVVVEHPVQYVVLHDDEN
ASFYNHVIIVTEESAEVTYVENYLSNASGEGNQLNIISEVIAGANSNITYGSVDYMDKGF
TGHIIRRGITEADASINWALGLMNEGSQIIDNTTNLFGDRSTSSLKSVVVGTGEQKINLT
SKIVQYGKETDGYILKHGVMKEHASSVFNGIGYIKHGGTKSIANQESRVLMLSEHARGDA
NPILLIDEDDVQAGHAASVGRVDPDQLYYLMSRGISQREAERLVIHGFLDPVVRELPIED
VKRQLREVIERKVSK
139.
gtggttcaagaatatgatgtaatcgttataggtgcgggacatgcaggtgtagaagcaggt
ttagcatctgcaagacgtggtgctaaaacattaatgctaacaataaatttagataatatt
gcatttatgccatgtaacccatctgtaggtggaccagctaaaggtatcgttgttcgtgaa
attgatgctttaggtggacaaatggcaaaaacaatcgataaaacacacattcaaatgaga
atgttaaatacaggtaaaggacctgctgtaagagcactaagagcgcaagcagataaagta
ctttatcaacaagaaatgaaacgcgtgattgaagatgaagaaaatttgcatataatgcaa
ggtatggtagacgaacttattatagaagataatgaagttaaaggtgtacgtacaaatatt
ggtacagagtatttatctaaagcagtaattattacaacgggaacatttttacgtggtgaa
atcattttaggtaatatgaagtattcaagtggaccaaatcaccaattaccatcaatcaca
ttatcagacaatttaagagaacttggttttgatattgttcgttttaaaacaggtacacca
ccgcgtgtaaattcaaaaacaattgactattcgaagactgaaatacaaccaggtgacgat
gtaggtcgtgcattcagctttgaaacaacagaatatatattagatcaattgccatgttgg
ctaacgtatactaatgctgaaacacacaaagttatcgatgataatttacatctatctgca
atgtattcagggatgattaaaggaaccgggccacgttattgcccttcaattgaagataaa
tttgttcgatttaatgataagccgcgacatcaacttttcttagagcctgaaggtcgtaat
acaaatgaagtatatgtgcaaggattgtctacaagtcttcctgaacatgtgcaacgtcaa
atgttagagacgataccaggtcttgaaaaagcagatatgatgcgtgccggctacgcaatt
gaatatgatgcgattgtgccaacgcagttatggcctacacttgaaacgaaaatgattaaa
aacttatatactgcaggtcaaattaatggtacatctggttatgaagaagcagcaggacaa
ggattgatggcaggtattaacgctgcaggtaaagtgttaaacacaggcgaaaagatatta
agtcgttcagatgcatatattggtgtcttaatcgatgatcttgtaactaaaggtactaat
gaaccttatcgtttactaacatcacgtgcagaatatcgtttgttactacgtcatgataat
gctgatttgagattgacggatatgggatatgaacttggtatgatttctgaagaaagatat
gcacgttttaatgaaaaacgtcagcaaattgatgcggaaattaagcgtttatcagatatt
cgtattaaaccaaacgaacatacgcaagcgattattgaacaacatggtggttctcgctta
aaagatggtattttagctatcgatttattacgcagacctgaaatgacttacgatataatt
ttagaacttttagaagaagaacatcaattgaatgcagatgttgaagaacaagtagaaata
caaacaaaatatgaaggttatatcaataaatcactacaacaagttgagaaagttaagcgt
atggaagagaagaaaattccagaagacttagattatagtaagattgatagtttggcgact
gaagcgcgagaaaaattatcagaagtaaaacctttaaatattgcacaagcttctagaata
tcaggggtaaatccagcagacatatctatattattgatttacttagaacaaggtaaactc
caaagggtgagtgac
140.
MVQEYDVIVIGAGHAGVEAGLASARRGAKTLMLTINLDNIAFMPCNPSVGGPAKGIVVRE
IDALGGQMAKTIDKTHIQMRMLNTGKGPAVRALRAQADKVLYQQEMKRVIEDEENLHIMQ
GMVDELIIEDNEVKGVRTNIGTEYLSKAVIITTGTFLRGEIILGNMKYSSGPNHQLPSIT
LSDNLRELGFDIVRFKTGTPPRVNSKTIDYSKTEIQPGDDVGRAFSFETTEYILDQLPCW
LTYTNAETHKVIDDNLHLSAMYSGMIKGTGPRYCPSIEDKFVRFNDKPRHQLFLEPEGRN
TNEVYVQGLSTSLPEHVQRQMLETIPGLEKADMMRAGYAIEYDAIVPTQLWPTLETKMIK
NLYTAGQINGTSGYEEAAGQGLMAGINAAGKVLNTGEKILSRSDAYIGVLIDDLVTKGTN
EPYRLLTSRAEYRLLLRHDNADLRLTDMGYELGMISEERYARFNEKRQQIDAEIKRLSDI
RIKPNEHTQAIIEQHGGSRLKDGILAIDLLRRPEMTYDIILELLEEEHQLNADVEEQVEI
QTKYEGYINKSLQQVEKVKRMEEKKIPEDLDYSKIDSLATEAREKLSEVKPLNIAQASRI
SGVNPADISILLIYLEQGKLQRVSD
141.
LMINEREVFILIYLDNAAXTKAFEEVLDTYLKVNQSMYYNPNSPHKAGLQANQLLQQAKT
QINAMINSKTNYDVVFTSGATESNNLALKGIAYRKFDTAKEIITSVLEHPSVLEVVRYLE
AHEGFKVKYVDVKKDGSINLEHFKELMSDKVGLVTCMYVNNVTGQIQPIPQMAKVIKNYP
KAHFHVDAVQAFGKISMDLNNIDSISLSGHKFNGLKGQGVLLVNHIQNVEPTVHGGGQEY
GVRSGTVNLPNDIAMVKAMKIANENFEALNAFVTELNNDVRQFLNKYHGVYINSSTSGSP
FVLNISFPGVKGEVLVNAFSKYDIMISTTSACSSKRNKLNEVLAAMGLSDKSIEGSIRLS
FGATTTKEDIARFKEIFIIIYEEIKELLK
142.
MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAAEETGGTNTEAQPKTEAVA
SPTTTSEKAPETKPVANAVSVSNKEVEAPTSETKEAKEVKEVKAPKETKEVKPAAKATNN
TYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKKDGTQQFYHYASSVKPARVIFTD
SKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSST
HFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQD
KLPEKLKAEYKKKLEDTKKALDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNE
SMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPY
VEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANTDKSNKKEQQDNSAKKEATPAT
PSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKGVTLATKPTKGEVESSSTT
PTKVVSTTQNVAKPTTGSSKTTKDVVQTSAGSSEAKDSAPLQKANIKHTNDGHTQSQNNK
NTQENKAKSLPQTGEESNKDMTLPLMALLALSSIVAFVLPRKRKN
143.
atgagctggtttgataaattattcggcgaagataatgattcaaatgatgacttgattcat
agaaagaaaaaaagacgtcaagaatcacaaaatatagataacgatcatgactcattactg
cctcaaaataatgatatttatagtcgtccgaggggaaaattccgttttcctatgagcgta
gcttatgaaaatgaaaatgttgaacaatctgcagatactatttcagatgaaaaagaacaa
taccatcgagactatcgcaaacaaagccacgattctcgttcacaaaaacgacatcgccgt
agaagaaatcaaacaactgaagaacaaaattatagtgaacaacgtgggaattctaaaata
tcacagcaaagtataaaatataaagatcattcacattaccatacgaataagccaggtaca
tatgtttctgcaattaatggtattgagaaggaaacgcacaagccaaaaacacataatatg
tattctaataatacaaatcatcgtgctaaagattcaactccagattatcacaaagaaagt
ttcaagacttcagaggtaccgtcagctatttttggcacaatgaaacctaaaaagttagaa
aatggtcgtatccctgtaagtaaaccttcagaaaaagttgagtcagataaacaaaaatat
gataaatatgtagctaagacgcaaacgtctcaaaataaacaattagaacaagaaaaacaa
aatgatagtgttgtcaaacaaggaactgcatctaaatcatctgatgaaaatgtatcatca
acaacaaaatcaatgcctaattattcaaaagttgataatactatcaaaattgaaaatatt
tatgcttcacaaattgttgaagaaattagacgtgaacgagaacgtaaagtgcttcaaaag
cgtcgatttaaaaaagcgttgcaacaaaagcgtgaagaacataaaaacgaagagcaagat
gcaatacaacgtgcaattgatgaaatgtatgctaaacaagcggaacgctatgttggtgat
agttcattaaatgatgatagtgacttaacagataatagtacagatgctagtcagcttcat
acaaatggcatagagaatgaaactgtatcaaatgatgaaaataaacaagcgtcaatacaa
aatgaagacactaatgacactcatgtagatgaaagtccatacaattatgaggaagttagt
ttgaatcaagtatcgacaacaaaacaattgtcagatgatgaagttacggtttcgaatgta
acgtctcaacatcaatcagcactacaacataacgttgaagtaaatgataaagatgaacta
aaaaatcaatccagattaattgctgattcagaagaagatggagcaacgaataaagaagaa
tattcaggaagtcaaatcgatgatgcagaattttatgaattaaatgatacagaagtagat
gaggatactacttcaaatatcgaagataataccaatagaaacgcgtctgaaatgcatgta
gacgctcctaaaacgcaagagtacgcagtaactgaatctcaagtaaataatatcgataaa
acggttgataatgaaattgaattagcaccgcgtcataaaaaagatgaccaaacaaactta
agtgtcaactcattgaaaacgaatgatgtgaatgataatcatgttgtggaagattcaagc
atgaatgaaatagaaaagaataacgcagaaattacagaaaatgtgcaaaacgaagcagct
gaaagtgaacaaaatgtcgaagagaaaactattgaaaacgtaaatccaaagaaacagact
gaaaaggtttcaactttaagtaaaagaccatttaatgttgtcatgacgccatctgataaa
aagcgtatgatggatcgtaaaaagcattcaaaagtcaatgtgcctgaattaaagcctgta
caaagtaagcaagctgtgagtgaaagaatgcctgcgagtcaagccacaccatcatcaaga
tctgattcacaagagtcaaatacaaatgcatataaaacaaataatatgacatcaaacaat
gttgagaacaatcaacttattggtcatgcagaaacagaaaatgattatcaaaatgcacaa
caatattcagagcagaaaccttctgttgattcaactcaaacggaaatatttgaagaaagt
caagatgataatcaattggaaaatgagcaagttgatcaatcaacttcgtcttcagtttca
gaagtaagcgacataactgaagaaagcgaagaaacaacacatccaaacaatactagtgga
caacaagataatgatgatcaacaaaaagatttacagtcatcattttcaaataaaaatgaa
gatacagctaatgaaaatagacctcggacgaaccaacaagatgttgcaacaaatcaagct
gtacaaacatctaagccgatgattcgtaaaggcccaaatattaaattgccaagtgtttca
ttactagaagaaccacaagttattgagtcggacgaggactggattacagataaaaagaaa
gaactgaatgacgcattattttactttaatgtacctgcagaagtacaagatgtaactgaa
ggtccaagtgttacaagatttgaattatcagttgaaaaaggtgttaaagtttcaagaatt
acggcattacaagatgacattaaaatggcattggcagcgaaagatattcgtatagaagcg
cctattccaggaactagtcgtgttggtattgaagttccgaaccaaaatccaacgacagtc
aacttacgttctattattgaatctccaagttttaaaaatgctgaatctaaattaacagtt
gcgatggggtatagaattaataatgaaccattacttatggatattgctaaaacgccacac
gcactaattgcaggtgcaactggatcagggaaatcagtttgtatcaatagtattttgatg
tctttactatataaaaatcatcctgaggaattaagattattacttatcgatccaaaaatg
gttgaattagctccttataatggtttgccacatttagttgcaccggtaattacagatgtc
aaagcagctacacagagtttaaaatgggccgtagaagaaatggaacgacgttataagtta
tttgcacattaccatgtacgtaatataacagcatttaacaaaaaagcaccatatgatgaa
agaatgccaaaaattgtcattgtaattgatgagttggctgatttaatgatgatggctccg
caagaagttgaacagtctattgctagaattgctcaaaaagcgagagcatgtggtattcat
atgttagtagctacgcaaagaccatctgtcaatgtaattacaggtttaattaaagccaac
ataccaacaagaattgcatttatggtatcatcaagtgtagattcgagaacgatattagac
agtggtggagcagaacgcttgttaggatatggcgatatgttatatcttggtagcggtatg
aataaaccgattagagttcaaggtacatttgtttctgatgacgaaattgatgatgttgtt
gattttatcaaacaacaaagagaaccggactatctatttgaagaaaaagaattgttgaaa
aaaacacaaacacaatcacaagatgaattatttgatgatgtttgtgcatttatggttaat
gaaggacatatttcaacatcattaatccaaagacatttccaaattggctataatagagca
gcaagaattatcgatcaattagagcaactcggttatgtttcgagtgctaatggttcaaaa
ccaagggatgtttatgttacggaagcagatttaaataaagaa
144.
atgcctaaacgtaatgatatcaaaacaattttagtaatagggtctgggccaattatcata
ggtcaagcagctgaatttgattatgctggaacacaagcatgtctagctttaaaagaagag
ggatatcgagttattcttgtaaattcaaatccagcgacaatcatgactgataaggaaatt
gcggataaagtatatatcgaaccgttaactcatgattttatagcgcgaattatacgtaaa
gagcaacctgacgctttacttccaactttaggtggtcaaacaggtttaaacatggcgatt
caactacacgaaagtggtgtgcttcaagataataacgtccaattattaggaactgagcta
acatcaattcaacaagcagaagaccgtgaaatgtttagaacattaatgaatgatttaaac
gttcctgtaccagagagtgacattgtaaatacagtagagcaagcctttaaattcaaagag
caagtgggatacccgctaattgttagaccggcatttacgatgggtggtaccggaggcggt
atttgtcataatgatgaagaattacatgaaatcgtctcaaatggtcttcattatagtcca
gcaacgcaatgtttattagaaaaatctatcgcaggttttaaagaaatcgaatacgaagta
atgcgtgataaaaacgataatgccatcgttgtatgtaacatggaaaatattgatccagtt
ggtattcatacaggcgattcaattgttgtggctcctagtcaaacattatcagatgttgag
tatcaaatgttacgtgatgtttcattaaaagttattcgagctttaggtatcgaaggtggt
tgtaatgttcaattagcattagatccccattcattcgattattatattatagaagtaaat
ccgcgtgtatcacgttcatcagcgttagcttcaaaagcaacaggatatcctattgcaaaa
ttagctgctaaaatcgcggttggtctaacattagatgaaatgttaaatccaattacagga
acatcttatgcagcgtttgaaccaactttagactatgtgatttcaaaaataccaagattt
ccttttgataaatttgaaaaaggagaacgagagcttggcacacaaatgaaagcaacaggt
gaagttatggccattggtcgaacttacgaagaatcattgttaaaagcaattcgatcactt
gagtatggtgtgcatcacttaggattaccaaatggtgaaagcttcgatcttgattatatt
aaagaacgtatttcacaccaagatgatgaacgattatttttcatcggcgaagcaattaga
agaggcacaacattagaagaaattcataatatgactcagattgattacttcttcttacac
aagttccaaaacattattgatattgagcatcaattaaaagagcatcaaggtgatttagaa
tatcttaaatatgcaaaagattatggatttagtgataaaacaatagcgcatcgctttaat
atgacggaagaagaagtatatcaattgcgtatggaaaatgatattaaacctgtttacaag
atggttgatacttgcgcagctgaatttgaatcttcaacaccatattattatggtacatac
gaaactgaaaatgaatccatagttactgacaaagaaaaaatcttagtattaggctctgga
ccaattcgaatcggccaaggtgtagaatttgactatgcgacagttcatgccgtttgggca
attcaaaaagcagggtacgaagcgataattgtgaataacaatccagaaacagtttcaaca
gacttctcaatttctgacaaattatactttgaacctttaactgaagaagatgtgatgaat
atcattaatttagaaaaacctaaaggtgtcgttgtacaatttggaggacaaacagcgatt
aatttagcagacaaattggctaaacatggtgttaaaatacttggtacttcactagaaaat
ctaaatcgtgctgaagatagaaaagaatttgaagcactattaagaaaaattaacgtgcca
cagccacaagggaaaacagctacatcacctgaggaagcattagcgaatgctgcagaaatc
ggatatccggttgtagtaagaccttcttatgtattaggtggtcgcgcaatggaaattgta
gacaatgacaaagagttagaaaactatatgacccaggctgtaaaagcgagtccggaacat
ccggtactagtcgatagatatttaactggtaaagaaattgaagttgatgcgatttgtgat
ggagaaacggtcattattccaggaatcatggaacatattgaacgtgctggtgtgcatagt
ggtgactcaatcgctgtatatccaccacaaactttgacagaagacgagttagcaacactt
gaggactatactataaaattagctaaaggtttaaacatcattggcttaatcaacattcaa
ttcgttatagctcacgatggtgtgtatgttttagaagtaaatccacgttctagtagaacg
gtaccattcttaagtaaaattactgatattccaatggcacaattagctatgcgagcaatc
attggggaaaaactaacagatatgggttatcaagaaggggttcaaccatatgctgagggt
gtctttgtgaaagcaccagtatttagttttaataaattgaaaaatgttgatattacttta
ggacctgaaatgaagtcaacaggtgaagtgatggggaaagatactacattagaaaaggcg
ttattcaaagggttaacaggtagtggcgttgaagttaaagatcacggtacagtattaatg
accgtcagtgacaaagataaagaggaagttgttaaattggcacaacgcttaaatgaagtt
ggctataaaattttagcaacgtctggaacagctaataaattagctgagtatgacatacct
gcagaagtagtaggcaaaattggtggcgaaaatgatttattaacacgtattcaaaatggt
gatgttcaaatcgttataaatacaatgactaaaggtaaagaagtagaaagggatggcttc
caaattagacgtactacagttgaaaatggtattccatgtttgacatctttagatacagct
aatgccttaacgaatgtaattgaaagtatgacatttacaatgcgtcaaatg
145.
atgattaacagggataataaaaaggcaataacaaaaaagggtatgatttcaaatcgctta
aacaaattttcgattagaaagtatactgtaggaactgcatcgattttagtaggtacgaca
ttgatttttggtctagggaaccaagaagctaaagctgctgaaaacactagtacagaaaat
gcaaaacaagatgatgcaacgactagtgataataaagaagtagtgtcggaaactgaaaat
aattcgacaacagaaaataattcaacaaatccaattaagaaagaaacaaatactgattca
caaccagaagctaaaaaagaatcaacttcatcaagtactcaaaaacagcaaaataacgtt
acagctacaactgaaactaagcctcaaaacattgaaaaagaaaatgttaaaccttcaact
gataaaactgcgacagaagatacatctgttattttagaagagaagaaagcaccaaataat
acaaataacgatgtaactacaaaaccatctacaagtgaaccatctacaagtgaaattcaa
acaaaaccaactacacctcaagaatctacaaatattgaaaattcacaaccgcaaccaacg
ccttcaaaagtagacaatcaagttacagatgcaactaatccaaaagaaccagtaaatgtg
tcaaaagaagaacttaaaaaaaatcctgagaaattaaaagaattggttagaaatgatagc
aatacagatcattcaactaaaccagttgctacagctccaacaagtgttgcaccaaaacgt
gtaaacgcaaaaatgcgctttgcagttgcacaaccagcagcagttgcttcaaacaatgta
aatgatttaattaaagtgacgaagcaaacaatcaaagttggcgatggtaaagataatgtg
gcagcagcgcatgacggtaaagatattgaatatgatacagagtttacaattgacaataaa
gtcaaaaaaggcgatacaatgacgattaattatgataagaatgtaattccttcggattta
acagataaaaatgatcctatcgatattactgatccatcaggagaggtcattgctaaagga
acatttgataaagcaactaagcaaatcacatatacatttacagactatgtagataaatat
gaagatataaaatcacgcttaactctatattcgtatattgataaaaaaacagttccaaat
gagacaagtttgaatttaacatttgctacagcaggtaaagaaacaagccaaaatgtcact
gttgattatcaagatccaatggtccatggtgattcaaacattcaatctatctttacaaaa
ttagatgaagataagcaaactattgaacaacaaatttatgttaacccattgaaaaaatca
gcaaccaacactaaagttgatatagctggtagtcaagtagatgattatggaaatattaaa
ctaggaaatggtagcaccattattgaccaaaatacagaaataaaggtttataaagttaac
tctgatcaacaattgcctcaaagtaatagaatctatgattttagtcaatacgaagatgta
acaagtcaatttgataataaaaaatcatttagtaataatgtagcaacattggattttggt
gatattaattcagcctatattatcaaagttgttagtaaatatacacctacatcagatggc
gaactagatattgcccaaggtactagtatgagaacaactgataaatatggttattataat
tatgcaggatattcaaacttcatcgtaacttctaatgacactggcggtggcgacggtact
gttaaacctgaagaaaagttatacaaaattggtgactatgtatgggaagacgttgataaa
gacggtgttcaaggtacagattcaaaagaaaaaccaatggcaaacgttttagttacatta
acttacccggacggtactacaaaatcagtaagaacagatgctaatggtcattatgaattc
ggtggtttgaaagacggagaaacttatacagttaaattcgaaacgccaactggatatctt
ccaacaaaagtaaatggaacaactgatggtgaaaaagactcaaatggtagttcggttact
gttaaaattaatggtaaagatgatatgtctttagatactggtttttacaaagaacctaaa
tacaacttaggtgactatgtatgggaagatactaataaagatggtatccaagatgcaaat
gagccaggaatcaaagatgttaaggttacattaaaagatagtactggaaaagttattggt
acaactactactgatgcctcgggtaaatataaatttacagatttagataatggtaactat
acagtagaatttgaaacaccagcaggttacacgccaacggttaaaaatactacagctgat
gataaagattctaatggtttaacaacaacaggtgtcattaaagatgcagataatatgaca
ttagacaggggtttctataaaacaccaaaatacagtttaggtgattatgtttggtacgac
agtaataaagacggcaaacaagattcaactgaaaaaggtatcaaagatgtgacagttaca
ttgcaaaacgaaaaaggcgaagtaattggaacaactaaaacagatgaaaatggtaaatat
cgtttcgataatttagatagcggtaaatacaaagttatttttgaaaagcctgctggctta
acacaaacagttacaaatacaactgaagatgataaagatgcagatggtggcgaagttgac
gtaacaattacggatcatgatgatttcacacttgataacggatacttcgaagaagataca
tcagacagcgattcagactcagatagtgactcagacagcgactcagactcagacagcgac
tcagactcagacagtgattcagattcagacagcgactcagattcagatagcgactcagat
tcggacagcgattcagactcagatagcgactcagattcagatagcgattcagactcagac
agcgactcagattcagatagcgattcggactcagacagcgattcagactcagatagcgac
tcagactcagacagcgactcagattcagatagcgattcggactcagatagcgactcagat
tcagacagcgattcagactcagatagcgactcagattcagacagcgattcagactcagat
agcgactcagactcagacagtgattcagattcagacagcgactcagactcagatagcgac
tcagattcggacagcgactcagactcagatagcgactcagactcagacagtgattcagac
agcgattcagactcggatgcaggaaaacatacacctgttaaaccaatgagtactactaaa
gaccatcacaataaagcaaaagcattaccagaaacaggtagtgaaaataacggctcaaat
aacgcaacgttatttggtggattatttgcagcattaggttcattattgttattcggtcgt
cgcaaaaaacaaaacaaa
146.
atgactcatttattagagacatttgagatgtcaatagatcaccaggaagatggtttagtt
gttatttctatgcctgttactgataaagtaaaacaaccatttggatatttacatggtggg
gcttcgattgctttaggtgaaacagcatgttcattaggatctgctaatttaattgataca
accaaatttattccattaggtttagagatgaatgctaaccatattcattctgctaaagat
ggtcgtgttactgcgacagctgaaattattcatcgaggtaagtcgacacatgtatgggat
ataaaaattaagaatgacaaagaacaattaattacagttatgcgtggtacagttgctatt
aaacctttaaaa
147.
atggagcatacaactatgaaaataacaacgattgctaaaacaagtttagcactaggcctt
ttaacaacaggtgtaatcacaacgacaacgcaagcagcaaacgcgacaacaccatcttcc
actaaagtggaagcaccacaatcaacaccgccctcaactaaaatagaagcaccgcaatca
aaaccaaacgcgacaacaccgccctcaactaaagtagaagcaccgcaacaaacagcaaat
gcgacaacaccgccttcaactaaagtgacaacacctccatcaacaaacacgccacaacca
atgcaatctactaaatcagacacaccacaatcgccaaccacaaaacaagtaccaacagaa
ataaatcctaaatttaaagatttaagagcgtattatacgaaaccaagtttagaatttaaa
aatgagattggtattattttaaaaaaatggacgacaataagatttatgaatgttgtccca
gattatttcatatataaaattgctttagttggtaaagatgataaaaaatatggtgaagga
gtacataggaatgtcgatgtatttgtcgttttagaagaaaataattacaatctggaaaaa
tattctgtcggtggtatcacaaagagtaatagtaaaaaagttgatcacaaagcaggagta
agaattactaaggaagataataaaggtacaatctctcatgatgtttcagaattcaagatt
actaaagaacagatttccttgaaagaacttgattttaaattgagaaaacaacttattgaa
aaaaataatctgtacggtaacgttggttcaggtaaaattgttattaaaatgaaaaacggt
ggaaagtacacgtttgaattgcacaaaaaattacaagaaaatcgcatggcagatgtcatt
aatagtgaacaaattaaaaacatcgaagtgaatttgaaa
148.
atgaaaaagcaaataatttcgctaggcgcattagcagttgcatctagcttatttacatgg
gataacaaagcagatgcgatagtaacaaaggattatagtgggaaatcacaagttaatgct
gggagtaaaaatgggacattaatagatagcagatatttaaattcagctctatattatttg
gaagactatataatttatgctataggattaactaataaatatgaatatggagataatatt
tataaagaagctaaagataggttgttggaaaaggtattaagggaagatcaatatcttttg
gagagaaagaaatctcaatatgaagattataaacaatggtatgcaaattataaaaaagaa
aatcctcgtacagatttaaaaatggctaattttcataaatataatttagaagaactttcg
atgaaagaatacaatgaactacaggatgcattaaagagagcactggatgattttcacaga
gaagttaaagatattaaggataagaattcagacttgaaaacttttaatgcagcagaagaa
gataaagcaactaaggaagtatacgatctcgtatctgaaattgatacattagttgtatca
tattatggtgataaggattatggggagcacgcgaaagagttacgagcaaaactggactta
atccttggagatacagacaatccacataaaattacaaatgaacgtattaaaaaagaaatg
attgatgacttaaattcaattattgatgatttctttatggaaactaaacaaaatagaccg
aaatctataacgaaatataatcctacaacacataactataaaacaaatagtgataataaa
cctaattttgataaattagttgaagaaacgaaaaaagcagttaaagaagcagatgattct
tggaaaaagaaaactgtcaaaaaatacggagaaactgaaacaaaatcgccagtagtaaaa
gaagagaagaaagttgaagaacctcaagcacctaaagttgataaccaacaagaggttaaa
actacggctggtaaagctgaagaaacaacacaaccagttgcacaaccattagttaaaatt
ccacagggcacaattacaggtgaaattgtaaaaggtccggaatatccaacgatggaaaat
aaaacggtacaaggtgaaatcgttcaaggtcccgattttctaacaatggaacaaagcggc
ccatcattaagcaataattatacaaacccaccgttaacgaaccctattttagaaggtctt
gaaggtagctcatctaaacttgaaataaaaccacaaggtactgaatcaacgttaaaaggt
actcaaggagaatcaagtgatattgaagttaaacctcaagcaactgaaacaacagaagct
tctcaatatggtccgagaccgcaatttaacaaaacacctaaatatgttaaatatagagat
gctggtacaggtatccgtgaatacaacgatggaacatttggatatgaagcgagaccaaga
ttcaataagccatcagaaacaaatgcatataacgtaacaacacatgcaaatggtcaagta
tcatacggagctcgtccgacatacaagaagccaagcgaaacgaatgcatacaatgtaaca
acacatgcaaacggccaagtatcatacggagctcgtccgacacaaaacaagccaagcaaa
acaaacgcatataacgtaacaacacatggaaacggccaagtatcatatggcgctcgccca
acacaaaacaagccaagcaaaacaaatgcatacaacgtaacaacacatgcaaacggtcaa
gtgtcatacggagctcgcccgacatacaagaagccaagtaaaacaaatgcatacaatgta
acaacacatgcagatggtactgcgacatatgggcctagagtaacaaaa
149.
atgaaaaaattagcaacagtaggttctttaattgtaacaagcactttagtattctcaagt
atgccttttcaaaatgcgcatgccgacacaacttcaatgaatgtgtcgaataaacaaagc
caaaatgtacaaaatcatcgtccttatggcggagtagtaccacaaggaatgacgcaagca
caatatactgaattagagaaagctttaccccaattaagcgctggcagtaatatgcaagac
tataatatgaaattgtatgatgcgacgcaaaatattgctgataaatacaatgtgataatt
acaactaatgtaggggtatttaaaccacatgctgttagagatatgaatggccatgcgtta
cctttaacaaaagatggcaatttttatcaaacgaatgtagatgcaaatggtgttaatcat
ggtggtagtgaaatggtgcaaaataaaacaggtcatatgagtcaacaaggccatatgaat
cagaacacacacatgaaccaacagccacacatgcaacaaggtcatatgcaatcatcaaac
catcaaatgatgagtccaaaagcaaatatgcattcatcaaatcatcaaatgaaccaaagt
aacaaaaaagttttaccagctgctggtgaaagtatgacatcaagtattcttactgcaagt
attgccgcactactattagtatctgggttattcttagcatttagacgacgttcaacaaat
aaa
150.
gtgcttaggagtgatttttatatgtcttattccattgttagagtttcaaaagttaaatct
ggaacaaatacaacgggcatacaaaaacatgttcaaagagaaaataataattatgaaaat
gaagatatagaccatagtaaaacttacttaaattatgatttggtaaatgctaataaacag
aattttaataacttgattgatgaaaaaatcgaacagaattatacaggcaaaagaaaaatt
agaacagacgcgattaaacacattgatggtttaattacatcagacaatgatttctttgat
aatcaaacgccagaagatacaaagcagttttttgaatatgctaaagagtttttagaacaa
gaatacggtaaagataatttattatatgcaacagttcacatggacgaaaaaacaccacat
atgcattatggcgttgttccaataactgatgatggtcgtttaagtgctaaagaagttgta
ggtaataaaaaagctttaacagcgtttcaagatagatttaatgagcatgttaaacaacga
ggatatgatttagaacgtgggcaatcaagacaagtaacaaatgctaaacatgagcaaata
agtcagtataaacaaaaaacagaatatcataagcaagaatatgaacgtgagagccaaaaa
acagaccatataaagcaaaagaacgataaattaatgcaagagtaccaaaaatcgttaaat
acgcttaaaaagcctataaatgttccgtatgagcaagaaactgaaaaagtaggtggttta
tttagcaaagaaatacaagaaactggaaatgttgtaataagccaaaaagatttcaatgaa
tttcagaaacagataaaagctgctcaagatatttcggaagattacgagtatataaagtct
ggtagagccttagatgataaagataaggaaatacgagagaaagatgatttattaaataaa
gcagttgagcgtattgaaaacgcagacgataattttaaccaactttacgaaaatgcaaag
ccacttaaagagaatatagaaatagcgttaaagcttttaaaaatcttactaaaagagtta
gaacgagttttaggaagaaatacctttgcggaaagagttaataagttaacagaagatgaa
cctatggca
151.
MSWFDKLFGEDNDSNDDLIHRKKKRRQESQNIDNDHDSLLPQNNDIYSRPRGKFRFPMSV
AYENENVEQSADTISDEKEQYHRDYRKQSHDSRSQKRHRRRRNQTTEEQNYSEQRGNSKI
SQQSIKYKDHSHYHTNKPGTYVSAINGIEKETHKPKTHNMYSNNTNHRAKDSTPDYHKES
FKTSEVPSAIFGTMKPKKLENGRIPVSKPSEKVESDKQKYDKYVAKTQTSQNKQLEQEKQ
NDSVVKQGTASKSSDENVSSTTKSMPNYSKVDNTIKIENIYASQIVEEIRRERERKVLQK
RRFKKALQQKREEHKNEEQDAIQRAIDEMYAKQAERYVGDSSLNDDSDLTDNSTDASQLH
TNGIENETVSNDENKQASIQNEDTNDTHVDESPYNYEEVSLNQVSTTKQLSDDEVTVSNV
TSQHQSALQHNVEVNDKDELKNQSRLIADSEEDGATNKEEYSGSQIDDAEFYELNDTEVD
EDTTSNIEDNTNRNASEMHVDAPKTQEYAVTESQVNNIDKTVDNEIELAPRHKKDDQTNL
SVNSLKTNDVNDNHVVEDSSMNEIEKNNAEITENVQNEAAESEQNVEEKTIENVNPKKQT
EKVSTLSKRPFNVVMTPSDKKRMMDRKKHSKVNVPELKPVQSKQAVSERMPASQATPSSR
SDSQESNTNAYKTNNMTSNNVENNQLIGHAETENDYQNAQQYSEQKPSVDSTQTEIFEES
QDDNQLENEQVDQSTSSSVSEVSDITEESEETTHPNNTSGQQDNDDQQKDLQSSFSNKNE
DTANENRPRTNQQDVATNQAVQTSKPMIRKGPNIKLPSVSLLEEPQVIESDEDWITDKKK
ELNDALFYFNVPAEVQDVTEGPSVTRFELSVEKGVKVSRITALQDDIKMALAAKDIRIEA
PIPGTSRVGIEVPNQNPTTVNLRSIIESPSFKNAESKLTVAMGYRINNEPLLMDIAKTPH
ALIAGATGSGKSVCINSILMSLLYKNHPEELRLLLIDPKMVELAPYNGLPHLVAPVITDV
KAATQSLKWAVEEMERRYKLFAHYHVRNITAFNKKAPYDERMPKIVIVIDELADLMMMAP
QEVEQSIARIAQKARACGIHMLVATQRPSVNVITGLIKANIPTRIAFMVSSSVDSRTILD
SGGAERLLGYGDMLYLGSGMNKPIRVQGTFVSDDEIDDVVDFIKQQREPDYLFEEKELLK
KTQTQSQDELFDDVCAFMVNEGHISTSLIQRHFQIGYNRAARIIDQLEQLGYVSSANGSK
PRDVYVTEADLNKE
152.
MPKRNDIKTILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYRVILVNSNPATIMTDKEI
ADKVYIEPLTHDFIARIIRKEQPDALLPTLGGQTGLNMAIQLHESGVLQDNNVQLLGTEL
TSIQQAEDREMFRTLMNDLNVPVPESDIVNTVEQAFKFKEQVGYPLIVRPAFTMGGTGGG
ICHNDEELHEIVSNGLHYSPATQCLLEKSIAGFKEIEYEVMRDKNDNAIVVCNMENIDPV
GIHTGDSIVVAPSQTLSDVEYQMLRDVSLKVIRALGIEGGCNVQLALDPHSFDYYIIEVN
PRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMLNPITGTSYAAFEPTLDYVISKIPRF
PFDKFEKGERELGTQMKATGEVMAIGRTYEESLLKAIRSLEYGVHHLGLPNGESFDLDYI
KERISHQDDERLFFIGEAIRRGTTLEEIHNMTQIDYFFLHKFQNIIDIEHQLKEHQGDLE
YLKYAKDYGFSDKTIAHRFNMTEEEVYQLRMENDIKPVYKMVDTCAAEFESSTPYYYGTY
ETENESIVTDKEKILVLGSGPIRIGQGVEFDYATVHAVWAIQKAGYEAIIVNNNPETVST
DFSISDKLYFEPLTEEDVMNIINLEKPKGVVVQFGGQTAINLADKLAKHGVKILGTSLEN
LNRAEDRKEFEALLRKINVPQPQGKTATSPEEALANAAEIGYPVVVRPSYVLGGRAMEIV
DNDKELENYMTQAVKASPEHPVLVDRYLTGKEIEVDAICDGETVIIPGIMEHIERAGVHS
GDSIAVYPPQTLTEDELATLEDYTIKLAKGLNIIGLINIQFVIAHDGVYVLEVNPRSSRT
VPFLSKITDIPMAQLAMRAIIGEKLTDMGYQEGVQPYAEGVFVKAPVFSFNKLKNVDITL
GPEMKSTGEVMGKDTTLEKALFKGLTGSGVEVKDHGTVLMTVSDKDKEEVVKLAQRLNEV
GYKILATSGTANKLAEYDIPAEVVGKIGGENDLLTRIQNGDVQIVINTMTKGKEVERDGF
QIRRTTVENGIPCLTSLDTANALTNVIESMTFTMRQM
153.
MINRDNKKAITKKGMISNRLNKFSIRKYTVGTASILVGTTLIFGLGNQEAKAAENTSTEN
AKQDDATTSDNKEVVSETENNSTTENNSTNPIKKETNTDSQPEAKKESTSSSTQKQQNNV
TATTETKPQNIEKENVKPSTDKTATEDTSVILEEKKAPNNTNNDVTTKPSTSEPSTSEIQ
TKPTTPQESTNIENSQPQPTPSKVDNQVTDATNPKEPVNVSKEELKKNPEKLKELVRNDS
NTDHSTKPVATAPTSVAPKRVNAKMRFAVAQPAAVASNNVNDLIKVTKQTIKVGDGKDNV
AAAHDGKDIEYDTEFTIDNKVKKGDTMTINYDKNVIPSDLTDKNDPIDITDPSGEVIAKG
TFDKATKQITYTFTDYVDKYEDIKSRLTLYSYIDKKTVPNETSLNLTFATAGKETSQNVT
VDYQDPMVHGDSNIQSIFTKLDEDKQTIEQQIYVNPLKKSATNTKVDIAGSQVDDYGNIK
LGNGSTIIDQNTEIKVYKVNSDQQLPQSNRIYDFSQYEDVTSQFDNKKSFSNNVATLDFG
DINSAYIIKVVSKYTPTSDGELDIAQGTSMRTTDKYGYYNYAGYSNFIVTSNDTGGGDGT
VKPEEKLYKIGDYVWEDVDKDGVQGTDSKEKPMANVLVTLTYPDGTTKSVRTDANGHYEF
GGLKDGETYTVKFETPTGYLPTKVNGTTDGEKDSNGSSVTVKINGKDDMSLDTGFYKEPK
YNLGDYVWEDTNKDGIQDANEPGIKDVKVTLKDSTGKVIGTTTTDASGKYKFTDLDNGNY
TVEFETPAGYTPTVKNTTADDKDSNGLTTTGVIKDADNMTLDRGFYKTPKYSLGDYVWYD
SNKDGKQDSTEKGIKDVTVTLQNEKGEVIGTTKTDENGKYRFDNLDSGKYKVIFEKPAGL
TQTVTNTTEDDKDADGGEVDVTITDHDDFTLDNGYFEEDTSDSDSDSDSDSDSDSDSDSD
SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD
SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD
SDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGSENNGSN
NATLFGGLFAALGSLLLFGRRKKQNK
154.
MTHLLETFEMSIDHQEDGLVVISMPVTDKVKQPFGYLHGGASIALGETACSLGSANLIDT
TKFIPLGLEMNANHIHSAKDGRVTATAEIIHRGKSTHVWDIKIKNDKEQLITVMRGTVAI
KPLK
155.
MEHTTMKITTIAKTSLALGLLTTGVITTTTQAANATTPSSTKVEAPQSTPPSTKIEAPQS
KPNATTPPSTKVEAPQQTANATTPPSTKVTTPPSTNTPQPMQSTKSDTPQSPTTKQVPTE
INPKFKDLRAYYTKPSLEFKNEIGIILKKWTTIRFMNVVPDYFIYKIALVGKDDKKYGEG
VHRNVDVFVVLEENNYNLEKYSVGGITKSNSKKVDHKAGVRITKEDNKGTISHDVSEFKI
TKEQISLKELDFKLRKQLIEKNNLYGNVGSGKIVIKMKNGGKYTFELHKKLQENRMADVI
NSEQIKNIEVNLK
156.
MKKQIISLGALAVASSLFTWDNKADAIVTKDYSGKSQVNAGSKNGTLIDSRYLNSALYYL
EDYIIYAIGLTNKYEYGDNIYKEAKDRLLEKVLREDQYLLERKKSQYEDYKQWYANYKKE
NPRTDLKMANFHKYNLEELSMKEYNELQDALKRALDDFHREVKDIKDKNSDLKTFNAAEE
DKATKEVYDLVSEIDTLVVSYYGDKDYGEHAKELRAKLDLILGDTDNPHKITNERIKKEM
IDDLNSIIDDFFMETKQNRPKSITKYNPTTHNYKTNSDNKPNFDKLVEETKKAVKEADDS
WKKKTVKKYGETETKSPVVKEEKKVEEPQAPKVDNQQEVKTTAGKAEETTQPVAQPLVKI
PQGTITGEIVKGPEYPTMENKTVQGEIVQGPDFLTMEQSGPSLSNNYTNPPLTNPILEGL
EGSSSKLEIKPQGTESTLKGTQGESSDIEVKPQATETTEASQYGPRPQFNKTPKYVKYRD
AGTGIREYNDGTFGYEARPRFNKPSETNAYNVTTHANGQVSYGARPTYKKPSETNAYNVT
THANGQVSYGARPTQNKPSKTNAYNVTTHGNGQVSYGARPTQNKPSKTNAYNVTTHANGQ
VSYGARPTYKKPSKTNAYNVTTHADGTATYGPRVTK
157.
MKKLATVGSLIVTSTLVFSSMPFQNAHADTTSMNVSNKQSQNVQNHRPYGGVVPQGMTQA
QYTELEKALPQLSAGSNMQDYNMKLYDATQNIADKYNVIITTNVGVFKPHAVRDMNGHAL
PLTKDGNFYQTNVDANGVNHGGSEMVQNKTGHMSQQGHMNQNTHMNQQPHMQQGHMQSSN
HQMMSPKANMHSSNHQMNQSNKKVLPAAGESMTSSILTASIAALLLVSGLFLAFRRRSTNK
158.
VLRSDFYMSYSIVRVSKVKSGTNTTGIQKHVQRENNNYENEDIDHSKTYLNYDLVNANKQ
NFNNLIDEKIEQNYTGKRKIRTDAIKHIDGLITSDNDFFDNQTPEDTKQFFEYAKEFLEQ
EYGKDNLLYATVHMDEKTPHMHYGVVPITDDGRLSAKEVVGNKKALTAFQDRFNEHVKQR
GYDLERGQSRQVTNAKHEQISQYKQKTEYHKQEYERESQKTDHIKQKNDKLMQEYQKSLN
TLKKPINVPYEQETEKVGGLFSKEIQETGNVVISQKDFNEFQKQIKAAQDISEDYEYIKS
GRALDDKDKEIREKDDLLNKAVERIENADDNFNQLYENAKPLKENIEIALKLLKILLKEL
ERVLGRNTFAERVNKLTEDEPMA
159.
atgatgaaaaagttaaaagcgagtgaaattagacaaaaatatctagatttctttgttgaa
aaaggacatatggttgaaccttctgcaccattagtgccaattgatgatgatacattatta
tggattaattcaggtgtagcaacattaaagaaatattttgatggacgtgaaacacctaaa
aagccaagaattgtaaactctcaaaaagctattcgtacaaatgatattgaaaatgttggt
ttcacagcgcgtcaccatacattctttgaaatgttaggtaacttctcaattggtgattat
tttaaacaagaagcgattgaatttgcttgggaatttttaacgagtgataaatggatgggt
atggagccagataaattgtacgttacgattcatccggaagatatggaagcatacaacatt
tggcataaagatattgggcttgaagaaagtcgtattattcgcattgaaggtaacttctgg
gatattggtgaagggccttcaggaccgaacactgagattttctatgatcgcggagaagca
tatggacaagacgatccggcagaagaaatgtatccaggtggagaaaatgaacgctatctt
gaagtatggaacttagtatttagtgaattcaatcataataaagatcatagttacacacca
ttacctaataaaaatattgatactggcatggggcttgagcgtatggcctcagtttctcaa
aatgtacgtactaactatgaaacagatttatttatgcctataatgaatgaaatcgaaaaa
gtatcaggtaaacaatatttagtaaacaacgaacaagatgtggcatttaaagtaattgct
gaccacattcgtacgattgcatttgcaatttctgatggtgcattacctgccaatgaaggt
agagggtatgtattacgtcgattgttacgtcgtgccgttcgttttagtcaaacgttagga
atcaatgagccatttatgtacaaacttgttgatattgttgcagacattatggaaccatat
tatccaaatgttaaggaaaaagcagatttcattaagcgtgttataaagtctgaagaagaa
cgattccatgaaacattagaagatggtttagcgattttaaatgaattaattaaaaaagct
aaagcgacaacaaatgaaattaatgggaaagatgcatttaaattgtatgatacgtatggg
ttcccaattgaattaactgaagaaatagcagtgcaagcaggattgaaagttgatatgaca
acattcgagtcagaaatgcaacaacaacgtgatcgtgcacgtcaagcacgtcaaaattct
caatcaatgcaagttcaaagtgaagtattgaaaaatattacatctgcaagtacttttgtt
ggttatgatactgcgacagctcaaacaacactaacacacttgatatacaatggtgaagaa
gtttcacaagttgaagcgggtgaaacagtatacttcatgttaacggaaacaccattttat
gcaatcagtggtggacaagttgcggatacaggtattgtttataatgacaattttgaaatt
gctgttagtgaagtaaccaaagcaccaaatggtcaaaacttgcataaaggagtagtacaa
tttggccaagtaaatgttggcgctacagtgtctgctgaagtgaaccaaaatgatcgacgt
gacattcaaaagaaccatagtgcaacacatttattacatgcagcgttgaaatcagtactg
ggtgatcatgttaaccaagctggttcactagtagaagcagatcgtttacgttttgatttc
tctcattttggtccaatgactaatgatgaaattgatcaagttgaacgcttagtaaatgaa
gaaatttggaaaggtattgacgttaacattcaagaaatggatattgcttcagctaaagaa
atgggcgcaatggcattattcggtgaaaaatatggtgatgttgtgcgtgtagtaaatatg
gcaccattttcaattgaattatgtggtggtattcatgtccgcaatacttctgaaattggc
ttattcaaaatagtaagtgagtcaggtacaggagctggtgtgcgtcgtattgaagcatta
acaggtaaagcagctttcttatatttagaagatattcaagagaaatttaatacgatgaaa
tcacagctgaaagtgaaatctgatgatcaagtagtcgataagttaacacaattacaagat
gaagaaaaagcattattaaaacaattagagcaacgtgacaaagaaatcacatcacttaaa
atgggtaatattgaagatcaagttgaagaaatcaatggctataaagtattggttactgaa
gtggatgtaccaaatgcgaaagcaattcgctcgacaatggacgattttaaatctaaacta
caagatacaattatcattcttgcaagtaatgttgatgataaagtatcgatggttgcaact
gtccctaaatctttaacaaataacgttaaagccggtgatcttatcaaacaaatggcacca
atcgttggtggtaaaggtggcggtcgtccagatatggctcaaggtggcggtacacaacct
gaaaatatctcaaaatcattaagctttattaaagattacattaaaaatcta
160.
MMKKLKASEIRQKYLDFFVEKGHMVEPSAPLVPIDDDTLLWINSGVATLKKYFDGRETPK
KPRIVNSQKAIRTNDIENVGFTARHHTFFEMLGNFSIGDYFKQEAIEFAWEFLTSDKWMG
MEPDKLYVTIHPEDMEAYNIWHKDIGLEESRIIRIEGNFWDIGEGPSGPNTEIFYDRGEA
YGQDDPAEEMYPGGENERYLEVWNLVFSEFNHNKDHSYTPLPNKNIDTGMGLERMASVSQ
NVRTNYETDLFMPIMNEIEKVSGKQYLVNNEQDVAFKVIADHIRTIAFAISDGALPANEG
RGYVLRRLLRRAVRFSQTLGINEPFMYKLVDIVADIMEPYYPNVKEKADFIKRVIKSEEE
RFHETLEDGLAILNELIKKAKATTNEINGKDAFKLYDTYGFPIELTEEIAVQAGLKVDMT
TFESEMQQQRDRARQARQNSQSMQVQSEVLKNITSASTFVGYDTATAQTTLTHLIYNGEE
VSQVEAGETVYFMLTETPFYAISGGQVADTGIVYNDNFEIAVSEVTKAPNGQNLHKGVVQ
FGQVNVGATVSAEVNQNDRRDIQKNHSATHLLHAALKSVLGDHVNQAGSLVEADRLRFDF
SHFGPMTNDEIDQVERLVNEEIWKGIDVNIQEMDIASAKEMGAMALFGEKYGDVVRVVNM
APFSIELCGGIHVRNTSEIGLFKIVSESGTGAGVRRIEALTGKAAFLYLEDIQEKFNTMK
SQLKVKSDDQVVDKLTQLQDEEKALLKQLEQRDKEITSLKMGNIEDQVEEINGYKVLVTE
VDVPNAKAIRSTMDDFKSKLQDTIIILASNVDDKVSMVATVPKSLTNNVKAGDLIKQMAP
IVGGKGGGRPDMAQGGGTQPENISKSLSFIKDYIKNL
161.
atgaatagtgagtttatatatggacgggtaacaaatttaggaggtaagattttgagttta
ataaagaaaaagaataaagatattcgcattataccattaggcggtgttggcgaaattgct
aaaaatatgtatatcgttgaagtagacgatgaaatgtttatgttagatgctggacttatg
tttccagaagacgaaatgctaggtattgatattgttataccagacatttcatacgtactt
gaaaataaagataaattgaagggtatattccttacacacggacatgagcacgcgattggt
gcagtgagttatgttttagaacaattagatgcaccagtatatggatctaaattgacaata
gcgttaattaaagaaaatatgaaagcccgtaatattgataaaaaagttcgctactataca
gttaataatgattcaattatgagattcaaaaacgtgaatattagtttctttaatacgaca
cacagtattcctgatagtttaggtgtttgtattcacacttcatatggtgccattgtgtat
acaggtgaatttaagtttgaccaaagtttacatggacattatgcaccagatattaaacgt
atggcagagattggtgaagaaggcgtatttgtcttaatcagtgattctactgaggcagag
aaacctggatataatactccggaaaatgtgattgaacatcatatgtatgatgcttttgca
aaagtgcgaggtcgcttgatagtttcatgttatgcttcgaactttatacgtattcagcaa
gttttaaatattgctagcaagctaaatcgtaaagtgtcatttttaggaagatcacttgaa
agttcatttaatattgctcgtaaaatggggtatttcgacattcctaaagatttgctaatt
cctataacagaagttgataattatcctaaaaatgaagtgataattatagctactggtatg
caaggagaacctgtagaagccttaagtcaaatggcgcaacataagcataaaattatgaat
atcgaagaaggcgattctgtatttttagcaattacggcttctgctaatatggaagttatc
attgcgaatacattaaatgagcttgtacgtgctggcgcacatattattccaaataacaaa
aagattcatgcttcaagtcatggttgcatggaagaattaaaaatgatgattaatattatg
aaacctgaatactttattcctgtacaaggtgaatttaaaatgcagatagcacatgcgaag
ctagcagctgaagcaggtgttgcaccagaaaagattttccttgtggaaaaaggagatgtc
attaattacaacggtaaagatatgatattaaatgaaaaggtaaattcaggaaatatttta
atagatggcattggtattggggatgtaggaaatatcgtgttgagagaccgtcatctttta
gcagaagatggtatctttattgctgttgtaacgttagatcctaaaaatagacgtatagct
gcgggacctgaaattcaatctcgtgggtttgtatatgtacgtgaaagtgaagacttatta
cgtgaagcagaagagaaagtacgtgaaatagtagaggctggtttacaagaaaaacgcata
gaatggtctgaaattaaacaaaatatgcgtgatcaaattagtaaactattattcgaaagt
acaaaacgtcgtcctatgattattccagtaatttctgaaatt
162.
MNSEFIYGRVTNLGGKILSLIKKKNKDIRIIPLGGVGEIAKNMYIVEVDDEMFMLDAGLM
FPEDEMLGIDIVIPDISYVLENKDKLKGIFLTHGHEHAIGAVSYVLEQLDAPVYGSKLTI
ALIKENMKARNIDKKVRYYTVNNDSIMRFKNVNISFFNTTHSIPDSLGVCIHTSYGAIVY
TGEFKFDQSLHGHYAPDIKRMAEIGEEGVFVLISDSTEAEKPGYNTPENVIEHHMYDAFA
KVRGRLIVSCYASNFIRIQQVLNIASKLNRKVSFLGRSLESSFNIARKMGYFDIPKDLLI
PITEVDNYPKNEVIIIATGMQGEPVEALSQMAQHKHKIMNIEEGDSVFLAITASANMEVI
IANTLNELVRAGAHIIPNNKKIHASSHGCMEELKMMINIMKPEYFIPVQGEFKMQIAHAK
LAAEAGVAPEKIFLVEKGDVINYNGKDMILNEKVNSGNILIDGIGIGDVGNIVLRDRHLL
AEDGIFIAVVTLDPKNRRIAAGPEIQSRGFVYVRESEDLLREAEEKVREIVEAGLQEKRI
EWSEIKQNMRDQISKLLFESTKRRPMIIPVISEI
163.
atggaaataacaatgcctaagttaggtgagagtgttcatgaaggcaccattgaacaatgg
ttagtttctgttggtgatcatattgatgaatatgaaccattatgtgaagttattacagat
aaagtgacagctgaagtcccttccacgatatcaggaacaattacagaaattttagttgaa
gcggggcagacagtagctattgatacaattatctgtaaaattgaaactgctgatgaaaag
acaaatgaaacaactgaagagatacaagcaaaagtggatgagcatactcagaaatctact
aaaaaagctagtgcaacagtggaacagacatctactgctaaacaaaatcaaccacgtaat
aatggtcgcttttcacctgttgtatttaaactcgcttcagagcatgacattgatttatca
caagttgtaggtagtggatttgaaggtcgtgtaactaagaaggatataatgtcagttatt
gaaaatggtggtaccacagctcaatctgacaaacaagttcaaacaaaatcaacatcagta
gatacatcaagtaaccaatcatctgaagacaatagtgaaaacagcacaataccagtaaat
ggtgtgcgtaaagcaattgcgcaaaatatggttaatagtgtaacagagattccacatgca
tggatgatgattgaagtagatgctacaaatcttgtgaaaacgagaaatcattataaaaac
agctttaaaaataaagaaggatataatctaacgttctttgctttctttgtaaaagctgta
gcagatgctttaaaagcatatcctttattaaatagtagctggcaaggaaatgaaattgtc
ttacataaagacattaatatttcaattgctgttgctgatgaaaataaattatacgtacct
gtgattaagcatgcagacgaaaagtcaatcaaaggtatagctagagaaattaatacttta
gcaacgaaagcgcgtaataagcaattgacagctgaagatatgcagggcggtacatttacg
gtaaataatactggtacatttggttcagtatcatcaatgggtattataaatcatccacaa
gcagcgattttacaagtagaatcaatcgttaaaaagccagtagtaattaatgatatgatt
gcaattcgtaacatggttaatttatgtatttcaattgatcatcgtattttagatggttta
caaacaggtaaatttatgaatcatattaaacagcgtatcgaacagtatactttagaaaat
acaaatatatat
164.
MEITMPKLGESVHEGTIEQWLVSVGDHIDEYEPLCEVITDKVTAEVPSTISGTITEILVE
AGQTVAIDTIICKIETADEKTNETTEEIQAKVDEHTQKSTKKASATVEQTSTAKQNQPRN
NGRFSPVVFKLASEHDIDLSQVVGSGFEGRVTKKDIMSVIENGGTTAQSDKQVQTKSTSV
DTSSNQSSEDNSENSTIPVNGVRKAIAQNMVNSVTEIPHAWMMIEVDATNLVKTRNHYKN
SFKNKEGYNLTFFAFFVKAVADALKAYPLLNSSWQGNEIVLHKDINISIAVADENKLYVP
VIKHADEKSIKGIAREINTLATKARNKQLTAEDMQGGTFTVNNTGTFGSVSSMGIINHPQ
AAILQVESIVKKPVVINDMIAIRNMVNLCISIDHRILDGLQTGKFMNHIKQRIEQYTLEN
TNIY
165.
166.
167.
atggaggacaacatgatttatgcaggtattttagcaggaggtattggttcgagaatgggg
aacgtgccattaccaaaacaatttttagatattgataataaaccgattttaatccataca
attgagaagttcattttagtgagtgaatttaatgagattattatcgcaacgccagcacag
tggatttcccatacacaggatattttaaaaaaatataacattacagatcaacgtgtcaaa
gtagttgcaggtggtacggatcgaaatgaaacaattatgaacattatcgaccatattcgc
aatgtaaatggaattaataatgatgatgtgattgtaactcatgatgccgtaagaccattt
ttaactcaacgtattattaaagagaacattgaagtagcagcaaaatatggtgcagtagat
acagtcattgaagcaattgatacgattgtaatgtctaaagataaacagaacatacacagt
atccctgtaaggaatgaaatgtatcaaggccaaacaccacaatcatttaatattaaatta
ttacaagatagttatcgcgccttaagtagtgaacaaaaagaaatcttatcagatgcatgt
aaaatcattgtcgaatctggacatgcagttaaattggtacgtggagaactatacaacatt
aaagtgacaacaccgtatgatttaaaagtagcaaatgccattattcaaggtgatattgcc
gatgat
168.
MEDNMIYAGILAGGIGSRMGNVPLPKQFLDIDNKPILIHTIEKFILVSEFNEIIIATPAQ
WISHTQDILKKYNITDQRVKVVAGGTDRNETIMNIIDHIRNVNGINNDDVIVTHDAVRPF
LTQRIIKENIEVAAKYGAVDTVIEAIDTIVMSKDKQNIHSIPVRNEMYQGQTPQSFNIKL
LQDSYRALSSEQKEILSDACKIIVESGHAVKLVRGELYNIKVTTPYDLKVANAIIQGDIA
DD
169.
atgataatatattggtgtatgacagttaatggagggaacgaaatgaaagctttattactt
aaaacaagtgtatggctcgttttgctttttagtgtaatgggattatggcaagtctcgaac
gcggctgagcagcatacaccaatgaaagcacatgcagtaacaacgatagacaaagcaaca
acagataagcaacaagtaccgccaacaaaggaagcggctcatcattctggcaaagaagcg
gcaaccaacgtatcagcatcagcgcagggaacagctgatgatacaaacagcaaagtaaca
tccaacgcaccatctaacaaaccatctacagtagtttcaacaaaagtaaacgaaacacgc
gacgtagatacacaacaagcctcaacacaaaaaccaactcacacagcaacgttcaaatta
tcaaatgctaaaacagcatcactttcaccacgaatgtttgctgctaatgcaccacaaaca
acaacacataaaatattacatacaaatgatatccatggccgactagccgaagaaaaaggg
cgtgtcatcggtatggctaaattaaaaacagtaaaagaacaagaaaagcctgatttaatg
ttagacgcaggagacgccttccaaggtttaccactttcaaaccagtctaaaggtgaagaa
atggctaaagcaatgaatgcagtaggttatgatgctatggcagtcggtaaccatgaattt
gactttggatacgatcagttgaaaaagttagagggtatgttagacttcccgatgctaagt
actaacgtttataaagatggaaaacgcgcgtttaagccttcaacgattgtaacaaaaaat
ggtattcgttatggaattattggtgtaacgacaccagaaacaaagacgaaaacaagacct
gaaggcattaaaggcgttgaatttagagatccattacaaagtgtgacagcggaaatgatg
cgtatttataaagacgtagatacatttgttgttatatcacatttaggaattgatccttca
acacaagaaacatggcgtggtgattacttagtgaaacaattaagtcaaaatccacaattg
aagaaacgtattacagttattgatggtcattcacatacagtacttcaaaatggtcaaatt
tataacaatgatgcattggcacaaacaggtacagcacttgcgaatatcggtaagattaca
tttaattatcgcaatggagaggtatcgaatattaaaccgtcattgattaatgttaaagac
gttgaaaatgtaacaccgaacaaagcattagctgaacaaattaatcaagctgatcaaaca
tttagagcacaaactgcagaggtaattattccaaacaataccattgatttcaaaggagaa
agagatgacgttagaacgcgtgaaacaaatttaggaaacgcgattgcagatgctatggaa
gcgtatggcgttaagaatttctctaaaaagactgactttgccgtgacaaatggtggaggt
attcgtgcctctatcgcaaaaggtaaggtgacacgctatgatttaatctcagtattacca
tttggaaatacgattgcgcaaattgatgtaaaaggttcagacgtctggacggctttcgaa
catagtttaggcgcaccaacaacacaaaaggacggtaagacagtgttaacagcgaatggc
ggtttactacatatctctgattcaatccgtgtttactatgatataaataaaccgtctggc
aaacgaattaatgctattcaaattttaaataaagagacaggtaagtttgaaaatattgat
ttaaaacgtgtatatcacgtaacgatgaatgacttcacagcatcaggtggcgacggatat
agtatgttcggtggtcctagagaagaaggtatttcattagatcaagtactagcaagttat
ttaaaaacagctaacttagctaagtatgatacgacagaaccacaacgtatgttattaggt
aaaccagcagtaagtgaacaaccagctaaaggacaacaaggtagcaaaggtagtaagtct
ggtaaagatacacaaccaattggtgacgacaaagtgatggatccagcgaaaaaaccagct
ccaggtaaagttgtattgttgctagcgcatagaggaactgttagtagcggtacagaaggt
tctggtcgcacaatagaaggagctactgtatcaagcaagagtgggaaacaattggctaga
atgtcagtgcctaaaggtagcgcgcatgagaaacagttaccaaaaactggaactaatcaa
agttcaagcccagaagcgatgtttgtattattagcaggtataggtttaatcgcgactgta
cgacgtagaaaagctagc
170.
MIIYWCMTVNGGNEMKALLLKTSVWLVLLFSVMGLWQVSNAAEQHTPMKAHAVTTIDKAT
TDKQQVPPTKEAAHHSGKEAATNVSASAQGTADDTNSKVTSNAPSNKPSTVVSTKVNETR
DVDTQQASTQKPTHTATFKLSNAKTASLSPRMFAANAPQTTTHKILHTNDIHGRLAEEKG
RVIGMAKLKTVKEQEKPDLMLDAGDAFQGLPLSNQSKGEEMAKAMNAVGYDAMAVGNHEF
DFGYDQLKKLEGMLDFPMLSTNVYKDGKRAFKPSTIVTKNGIRYGIIGVTTPETKTKTRP
EGIKGVEFRDPLQSVTAEMMRIYKDVDTFVVISHLGIDPSTQETWRGDYLVKQLSQNPQL
KKRITVIDGHSHTVLQNGQIYNNDALAQTGTALANIGKITFNYRNGEVSNIKPSLINVKD
VENVTPNKALAEQINQADQTFRAQTAEVIIPNNTIDFKGERDDVRTRETNLGNAIADAME
AYGVKNFSKKTDFAVTNGGGIRASIAKGKVTRYDLISVLPFGNTIAQIDVKGSDVWTAFE
HSLGAPTTQKDGKTVLTANGGLLHISDSIRVYYDINKPSGKRINAIQILNKETGKFENID
LKRVYHVTMNDFTASGGDGYSMFGGPREEGISLDQVLASYLKTANLAKYDTTEPQRMLLG
KPAVSEQPAKGQQGSKGSKSGKDTQPIGDDKVMDPAKKPAPGKVVLLLAHRGTVSSGTEG
SGRTIEGATVSSKSGKQLARMSVPKGSAHEKQLPKTGTNQSSSPEAMFVLLAGIGLIATV
RRRKAS
171.
atgcaagagtaccaaaaatcgttaaatacgcttaaaaagcctataaatgttccgtatgag
caagaaactgaaaaagtaggtggtttatttagcaaagaaatacaagaaactggaaatgtt
gtaataagccaaaaagatttcaatgaatttcagaaacagataaaagctgctcaagatatt
tcggaagattacgagtatataaagtctggtagagccttagatgataaagataaggaaata
cgagagaaagatgatttattaaataaagcagttgagcgtattgaaaacgcagacgataat
tttaaccaactttacgaaaatgcaaagccacttaaagagaatatagaaatagcgttaaag
cttttaaaaatcttactaaaagagttagaacgagttttaggaagaaatacctttgcggaa
agagttaataagttaacagaagatgaaccaaaactaaatggtttagcaggaaacttagat
aaaaaaatgaatccagaattatattcagaacaggaacagcaacaagaacaacaaaagaat
caaaaacgagatagaggtatgcactta
172.
MQEYQKSLNTLKKPINVPYEQETEKVGGLFSKEIQETGNVVISQKDFNEFQKQIKAAQDI
SEDYEYIKSGRALDDKDKEIREKDDLLNKAVERIENADDNFNQLYENAKPLKENIEIALK
LLKILLKELERVLGRNTFAERVNKLTEDEPKLNGLAGNLDKKMNPELYSEQEQQQEQQKN
QKRDRGMHL
173.
atgaagatgataaacaaattaatcgttccggtaacagctagtgctttattattaggcgct
tgtggcgctagtgccacagactctaaagaaaatacattaatttcttctaaagctggagac
gtaacagttgcagatacaatgaaaaaaatcggtaaagatcaaattgcaaatgcatcattt
actgaaatgttaaataaaattttagctgataaatataaaaataaagttaatgataagaag
attgacgaacaaattgaaaaaatgcaaaagcaatacggcggtaaagataaatttgaaaag
gcccttcaacagcaaggtttaacagccgataaatataaagaaaatttacgtactgctgct
tatcataaagaattactatcagataaaattaaaatctctgattctgaaattaaagaagac
agcaagaaagcttcacacattttaattaaagttaaatctaagaaaagcgacaaagaaggc
ttagatgataaagaagcgaaacaaaaagctgaagaaattcaaaaagaagtttcaaaagat
ccaagtaaatttggtgaaatcgctaaaaaagaatcaatggatactggttcagctaaaaaa
gatggcgaattaggttatgttcttaaaggacaaactgataaagattttgaaaaagcacta
tttaagcttaaagatggtgaagtatcagaggttgttaaatcaagctttggatatcatatt
attaaagctgataaaccaacagactttaacagtgaaaaacaaagcctgaaagaaaaatta
gtcgatcagaaagtacaaaaaaatccaaaattattgactgatgcatacaaagatctatta
aaagaatacgatgttgactttaaagatcgtgatattaaatcagttgtcgaagataaaatc
ttaaaccctgaaaaacttaaacaaggtggcgcacaaggcggacaatccggcatgagccaa
174.
MKMINKLIVPVTASALLLGACGASATDSKENTLISSKAGDVTVADTMKKIGKDQIANASF
TEMLNKILADKYKNKVNDKKIDEQIEKMQKQYGGKDKFEKALQQQGLTADKYKENLRTAA
YHKELLSDKIKISDSEIKEDSKKASHILIKVKSKKSDKEGLDDKEAKQKAEEIQKEVSKD
PSKFGEIAKKESMDTGSAKKDGELGYVLKGQTDKDFEKALFKLKDGEVSEVVKSSFGYHI
IKADKPTDFNSEKQSLKEKLVDQKVQKNPKLLTDAYKDLLKEYDVDFKDRDIKSVVEDKI
LNPEKLKQGGAQGGQSGMSQ
175.
atgcttttagtattagctggttgctctaattctaacgataataatgaaagtaaaaaagat
gacgcagacaatggtaagaaacaagagattcaagttgcagcggcagcaagtttaacagat
gtaaccaagaaattagcttcagaatttaaaaaagagcataaaaatgctgatattaaattt
aactatggtggatcaggggcattaagaaaacaaattgaatcaggcgcacctgttgacgta
tttatgtctgcaaatactaaagatgtagatgcattaaaagacaagaataaagcgcatgat
acatataaatatgcgaaaaatagtctagtattaattggtgataaagattcaaattacact
tcagtaaaagacttaaaagacaatgataaattagcattaggtgaagtgaaaactgtacca
gcaggaaaatatgcgaaacagtatttagataacaataacttatttaaagaagtcgaaagt
aaaatcgtttatgctaaagatgtaaaacaagtattaaattatgttgaaaagggtaatgcg
aaacaaggttttgtgtataaaactgacttatataaacaaaataaaaaaattgatactgta
aaagtaattaaagaagtagaacttaagaagccaatcacatacgaagctggtgctacatca
gatagtaaattagcaaaagagtggatggaattcttaaaatcagataaagctaaagaaata
ctaaaagaataccactttgcagca
176.
MLLVLAGCSNSNDNNESKKDDADNGKKQEIQVAAAASLTDVTKKLASEFKKEHKNADIKF
NYGGSGALRKQIESGAPVDVFMSANTKDVDALKDKNKAHDTYKYAKNSLVLIGDKDSNYT
SVKDLKDNDKLALGEVKTVPAGKYAKQYLDNNNLFKEVESKIVYAKDVKQVLNYVEKGNA
KQGFVYKTDLYKQNKKIDTVKVIKEVELKKPITYEAGATSDSKLAKEWMEFLKSDKAKEI
LKEYHFAA
177.
ttggcatacacatacactttaaaagatattattgaaattacaggtgtaactaaaagaact
ttacattattacgatgaaataggattattagttccagataaaaatgataaaaattatcgc
gtttataaacagcaagacttagaaaaattacaaaagattttaatactcaagtcttttgat
tttgatatcgctaaaataaaacaatacatttcgtatgataatgaacaattgcgaaagtta
ttatcagagcaaataagcaagttagataaaaagatttctgacttacaattaattagacgc
tctgtatgtgaatttattaaaggactctctctaatagataccagcattttaaacaagaca
ctacagtcacaatatgataaagaagcatctataaaatatggtcatacgaaagcatatcaa
tcatttattagacgtaaagacagcttacaatcgcaggatatcagacataaattgacaact
atcttcaataaatttaatcatatgtctttgagtcattatccaatccaagattgtagtgat
ctcgtatttgagtggaaggcatttatgaacactatcgctgattttgatgatgaaacatta
tgctgtattgctaaaacatatgaagatgatacgcgtttcaaagattactttaattcatat
gataatcaaaatttagcatcatacatttcagaagctgttaattattttttgagcaatgtg
aataagagcgacaatttt
178.
MAYTYTLKDIIEITGVTKRTLHYYDEIGLLVPDKNDKNYRVYKQQDLEKLQKILILKSFD
FDIAKIKQYISYDNEQLRKLLSEQISKLDKKISDLQLIRRSVCEFIKGLSLIDTSILNKT
LQSQYDKEASIKYGHTKAYQSFIRRKDSLQSQDIRHKLTTIFNKFNHMSLSHYPIQDCSD
LVFEWKAFMNTIADFDDETLCCIAKTYEDDTRFKDYFNSYDNQNLASYISEAVNYFLSNV
NKSDNF
179.
atggcaaaaataaaagcaaatgaagcattagttaaagcattacaagcatgggatatagat
cacttgtatggtattccaggagactcaatcgacgcagtagtcgatagtttacgtacagtg
agagatcaatttaaattttatcatgtacgtcatgaagaagtagcaagcttagcggctgct
ggttacacaaaattaactggtaaaatcggtgtggcattaagtatcggtggccctggttta
attcatttattaaatggtatgtatgatgccaaaatggataatgtaccgcaattaatatta
tctggacaaacgaatagtacagcacttggaacgaaagcattccaagaaacaaatttacaa
aaattatgtgaagatgtagccgtttataatcaccaaattgaaaaaggtgacaatgtgttt
gaaatcgttaacgaagcaattcgtacggcatatgaacaaaaaggtgtagctgttgttatt
tgtcctaacgacttattaactgaaaaaattaaagatacaacgaataaaccagtagataca
tcaagaccaacagtagtatcaccaaaatataaagacatcaaaaaagcggttaaactaatt
aataaaagtaaaaagcctgtcatgttaattggtgtaggtgcgaaacatgcgaaagatgag
ctacgtgaatttattgaaatggctaaaattcctgtcattcattcattaccagctaaaaca
atcttgccggatgatcatccatatagtatcggtaacttaggtaaaatcggtaccaaaaca
tcttatcaaacaatgcaggaagcggatttattaattatggttggtacaaactatccatat
gtggattacttacctaagaaaaatattaaagccattcaaattgacacaaatcctaaaaat
atcggacatcgtttcaatattaatgtaggaattgttggagatagtaaaattgcgttgcat
cagttaactgaaaatattaaacatgttgctgaaagaccattcttaaacaaaacgttagaa
cgtaaagcggtttgggataaatggatggaacaagataaaaataataatagtaaaccatta
cgtccagaacgattaatggcatcaatcaataaatttattaaagatgatgcagtgatttca
gcagatgtaggtacagcaacagtttggtcaactcgatacttaaaccttggtgtaaataac
aagttcatcatttcaagttggttaggtacaatgggttgcggtcttccaggtgcaattgca
tcaaaaattgcatatccaaatagacaagccatcgcaattgctggtgacggtgcattccaa
atggtaatgcaagacttcgctacagcagtacaatatgatttacctttaactgtatttgta
cttaataacaaacagttagcatttattaaatatgaacaacaagcagctggtgaattagaa
tatgcagttgatttttctgatatggatcatgcaaaatttgctgaggcagcaggtggtaaa
ggttatacaattaagagtgctagcgaagtagatgctatagtcgaagaggcattagcacaa
gatgtaccaacgattgtagatgtatatgttgatcctaatgctgcgccattaccaggtaaa
attgtaaatgaagaagcgcttggttatggtaagtgggcatttagatcaattactgaagat
aaacatttagatttagatcaaattccaccaatttcagtggcagcaaaacgtttctta
180.
MAKIKANEALVKALQAWDIDHLYGIPGDSIDAVVDSLRTVRDQFKFYHVRHEEVASLAAA
GYTKLTGKIGVALSIGGPGLIHLLNGMYDAKMDNVPQLILSGQTNSTALGTKAFQETNLQ
KLCEDVAVYNHQIEKGDNVFEIVNEAIRTAYEQKGVAVVICPNDLLTEKIKDTTNKPVDT
SRPTVVSPKYKDIKKAVKLINKSKKPVMLIGVGAKHAKDELREFIEMAKIPVIHSLPAKT
ILPDDHPYSIGNLGKIGTKTSYQTMQEADLLIMVGTNYPYVDYLPKKNIKAIQIDTNPKN
IGHRFNINVGIVGDSKIALHQLTENIKHVAERPFLNKTLERKAVWDKWMEQDKNNNSKPL
RPERLMASINKFIKDDAVISADVGTATVWSTRYLNLGVNNKFIISSWLGTMGCGLPGAIA
SKIAYPNRQAIAIAGDGAFQMVMQDFATAVQYDLPLTVFVLNNKQLAFIKYEQQAAGELE
YAVDFSDMDHAKFAEAAGGKGYTIKSASEVDAIVEEALAQDVPTIVDVYVDPNAAPLPGK
IVNEEALGYGKWAFRSITEDKHLDLDQIPPISVAAKRFL
181.
gtagtagtttagggcttgcaacgcac
182.
caccatcatagaacatacaattgctagc
183.
ctgatactggacaacatagaga
184.
aagtaacgttatctttcgaatggt
185.
atttctggcactcaagtatatcaagac
186.
tggcttaggtgttggtgtaggc
187.
ataatgcaactacaactcagcc
188.
ttgatcgttgatgtattttgattagat
189.
ctacaataactacagccgttaca
190.
gtgaatgaagttataaccagcag
191.
cacgctaaagcatcagtgacaga
192.
agcattttgatgtgttgctgttgtgtt
193.
gaatccccaagcacctaaac
194.
gtaaacgttgatcaagcacact
195.
tttgcaataacagcaacatctggtgcag
196.
gaaacttctgaagctggaattgtacgg
197.
atgagaaaaactaaaattgtatgtacaattggaccagcttcagaatcagaagaaatgatt
gagaaattaatcaatgctggtatgaacgttgcacgattaaacttttcacatggtagtcat
gaagagcataaaggtagaattgatacaattcgtaaagtagctaaaagattagacaaaatt
gtagcaattttattagatacaaaaggtccagaaattcgtacgcataatatgaaagacggt
atcattgaacttgaacgtggcaacgaagttattgttagcatgaatgaagttgaaggaaca
cctgaaaagttctcagtaacatatgaaaacttaattaacgatgttcaagtaggttcatac
attttacttgatgatggcttaattgaattacaagttaaagatattgaccatgctaaaaaa
gaagttaaatgtgatattttaaactctggtgagcttaaaaacaaaaaaggtgttaactta
cctggcgtaagagtaagtttacctggtattacagaaaaagatgctgaagatatccgtttc
ggtattaaagaaaatgttgacttcattgcagcaagtttcgtacgtcgtcctagtgatgtt
ttagaaattcgtgaaattttagaagaacaaaaagctaacatttcagtattccctaaaatt
gaaaaccaagaaggtattgataatattgcggaaattcttgaagtgtctgatggtttaatg
gttgcacgtggtgacatgggtgttgaaattccacctgaaaaagtaccaatggttcaaaaa
gatttaatcagacaatgtaacaaattaggtaaaccagttattacagctacacaaatgtta
gattctatgcaacgtaacccacgtgctacacgtgcagaagctagtgacgttgccaacgca
atctatgatggtacagatgcagtaatgttatctggtgaaactgctgctggtttatatcct
gaagaagctgttaaaacaatgagaaatattgctgtatcagctgaagcagcccaagattac
aaaaagttattgtcagatcgtactaaattagttgaaacttcattagtgaatgctatcggt
atttcggttgcacatacagctttaaacttaaatgttaaagcaattgtagctgctactgaa
agtggttcaacggcacgtactatctccaaatatcgtccacattcagacattattgcggtg
actccaagtgaagaaactgcacgtcaatgttcaattgtttggggagttcaacctgtagtt
aaaaaaggacgtaagagtacagatgcattgttaaacaatgcagttgcaacagctgttgaa
actggtagagtatctaatggtgatttaatcattattactgctggtgtaccaactggtgaa
actggaactactaatatgatgaaaatccacctagttggtgacgaaattgctaatggtcaa
ggtattggacgtggatcagttgttggtactacgttagttgctgaaactgttaaagattta
gaaggtaaagatttatctgacaaagttatcgttactaactcaatcgatgaaacgtttgta
ccttatgtagaaaaagctttaggcttaattacagaagaaaatggtattacatcaccaagt
gcaattgttggtttagaaaaaggtattccaacagttgtaggtgtagaaaaagctgttaaa
aacataagcaataacatgttagttacgattgatgctgctcaaggtaaaatctttgaagga
tatgcaaacgtacta
198.
atgcaattcgataatattgacagtgctttaatggctttaaaaaatggagaaccaattatt
gtagtagatgatgagaatcgtgaaaatgaaggtgatttagtagcggttactgaatggatg
aacgataataccattaattttatggcgaaagaagcaaggggattaatatgcgcaccagtg
tctaaagatattgcacaacgtttggatttggtacaaatggttgatgataactccgacatc
tttggtacgcaatttacagtgagtattgatcatgtagatacaacaacaggaattagtgct
tatgaacgtacattgactgccaaaaagctcattgatcctagtagtgaagctaaagatttt
aatcgtcctggtcatttatttccattagtagcacaagataaaggcgtattagctagaaat
ggacacacagaagcggctgttgatttagctaaacttactggtgccaagcccgctggtgtc
atttgtgagattatgaatgatgacggcacgatggcgaaaggacaagatttacaaaagttt
aaagaaaaacatcaattaaagatgattacgattgatgatttaattgaatatcgtaaaaaa
ttagaaccagaaattgaatttaaggcaaaagtgaaaatgcctacagatttcggaacattt
gatatgtatggttttaaagcgacatacacagatgaagagatagttgtactgacaaaaggt
gcaattcgacaacatgaaaatgtacgcttacattctgcgtgccttacaggcgatattttc
catagtcaacgttgtgattgtggtgctcaacttgaatcgtctatgaagtatatcaatgaa
catggtggcatgattatttatctacctcaagaaggtcgtggcataggattgttaaacaaa
ttacgcgcatatgaattaattgagcaaggatatgatacagtaactgcaaatttagcatta
ggttttgatgaagatttgcgagattatcatattgctgcacagattttaaaatattttaac
atcgaacatatcaatttattaagtaataatccaagtaaatttgagggattaaaacaatat
ggcattgatattgcagaaagaattgaagttatcgtaccagaaacggtacataatcatgat
tatatggaaacgaaaaaaataaaaatgggtcatttaata
199.
atgaaaatgaaaaaattagtcaaatcatcagttgcttcatcaattgcactgcttttgcta
tcgaatacagttgatgcagctcaacatatcacacctgtaagcgagaaaaaagtagatgac
aaaatcactttatacaaaacaacagcaacatctgataatgataaattgaatatttctcaa
attttaacgtttaatttcattaaggataaaagttatgacaaagatacgttagtacttaag
gcagccggaaacattaattcaggttataaaaagcctaatccaaaagattacaattactca
cagttttattggggcggtaagtataatgtttcggttagttcagaatcaaatgatgctgta
aatgttgttgactatgcacctaaaaatcaaaatgaagaattccaagttcaacaaacatta
ggttattcttatggcggagatattaatatatctaatggcttatcaggtggattaaatgga
tcaaaatcattttcagaaacgataaattataaacaagaaagttacagaactacgattgat
agaaaaacaaatcataaatcaattggctggggtgttgaggcgcacaaaattatgaataat
ggttggggaccatatggtagagatagttatgacccaacatatggtaatgaactgttttta
ggcggtagacaaagtagttcaaatgctggtcaaaatttcttgccaacacatcaaatgcct
ttattggcgcgtggtaactttaacccagaatttataagcgtactttctcataaacaaaat
gatacaaaaaaatctaaaatcaaagtaacttaccaaagagaaatggatagatatactaat
caatggaatcgactacactgggttggtaataactacaaaaatcaaaatacagtaacgttt
acatctacttatgaagttgactggcaaaaccatactgttaaattaatcggtacggattct
aaagaaactaatcctggagta
200.
Atgaagaaaaaagcgttactaccattatttttaggtattatggtctttttggctggttgt
Gactattctaaacctgaaaaacgtagtgggtttttctacaatacattcgtagatccaatg
Aaaaatgtattggattggttgggaaataacttattaaacgacaattatggtttagctatt
Attatccttgtattggtaattcgtattattttattaccattcatgttgtcaaactataaa
Aatagtcatatgatgcgtcaaaaaatgaaagttgcaaagccagaagttgaaaaaattcaa
Gaaaaagtgaaacgtgcgcgtacacaagaagaaaaaatggctgcaaaccaagaattaatg
Caagtatataaaaagtatgacatgaacccgattaagagtatgttgggttgtttaccaatg
Ctaatccaattaccaatcatcatgggattatactttgtacttaaagaccaacttgtagat
Ggtttgtttaaatatccacacttcttatggttcgatttaggacgtcctgatatttggatt
Acaattattgccggtgttttatactttatccaagcatatgtatcaagtaaaacgatgcca
Gacgaacaacgtcaaatgggttacatgatgatggtcatttcaccaattatgattatctgg
Atttcattaagctcagcatcagcacttggtttgtactggtcagtcagtgcggcgttcctt
Gtagttcaaacacactttgcgaacatttattatgaaaaagtcgctaaaaaagaagtacaa
Cctttcattgaagcgtatgaaagagagcacaacggcggcagcaataaaaaaggcaaaaac
acacaagttgtgtctaaaaagaaaaagaaa
201.
atgaatttattcagacaacaaaaatttagtatcagaaaatttaatgtcggtattttttca
gctttaattgccactgttacttttatatctactaacccgacaacagcgtctgcagcagag
caaaatcagcctgcacaaaatcaaccagcacaaccagctgatgccaatacacagcctaac
gcaaatgctggtgctcaagctaatcctacagcacagccagctgcacctgccaaccaagga
caaccagcagtacaaccagcaaaccaaggtggacaggctaatccagcaggaggagcagca
caaccaaatacacaaccagctggacaaggtaatcaagctgatccgaataacgctgcacaa
gcacaacctggaaatcaagcaacaccggcaaaccaagcaggtcaaggaaataaccaagca
acacctaataataatgcaacaccggcaaatcaaacacagccagcgaatgctccagcagca
gcgcaaccagcagcacctgtagcagcaaacgcacaaactcaagatccaaatgctagcaat
actggtgaaggcagtattaatacgacattaacatttgatgatcctgccatatcaacagat
gagaatagacaggatccaactgtaactgttacagataaagtaaatggttattcattaatt
aacaacggtaagattggtttcgttaactcagaattaagacgaagcgatatgtttgataag
aataaccctcaaaactatcaagctaaaggaaacgtggctgcattaggtcgtgtgaatgca
aatgattctacagatcatggtaactttaacggtatttcaaaaactgtaaatgtaaaacca
gattcagaattaattattaactttactactatgcaaacgaatagtaagcaaggtgcaaca
aatttagttattaaagatgctaagaaaaatactgaattagcaactgtaaatgttgctaag
actggtactgcacatttatttaaagtaccaactgatgctgatcgtttagatttacaattt
attcctgacaatacagcagttgctgatgcttcaagaattacaacaaataaagatggttat
aaatactattcattcattgataatgtaggtctattctcaggatcacatttatatgtcaaa
aatagagatttagcaccgaaagcaactaacaataaagaatatactattaatactgaaatc
ggtaacaatggtaattttggtgcttcattaaaagcagatcaatttaaatatgaagtaaca
ttaccacaaggtgtaacttacgttaataattcattaactacaacattccctaatggtaat
gaagacagtacagtattgaaaaatatgactgttaattatgatcaaaatgcaaataaagtt
acatttacaagccaaggtgtgacaacggcacgtggtacacacactaaagaagttttattc
ccagataaatctttaaaattatcatataaagttaatgttgcgaatatcgatacacctaaa
aatattgattttaatgaaaaattaacatatcgtactgcttcagatgttgtaattaataat
gcgcaaccagaagttacactaactgcagatccattttcagtagcggttgaaatgaacaaa
gatgcgttgcaacaacaagtaaactcacaagttgataatagtcattacacaacagcatca
attgcagaatacaataaacttaaacaacaagcagatactattttaaatgaagatgcgaat
catgttaaaactgcaaatcgtgcatctcaagcggatattgatggtttagtaactaaatta
caagctgcattaattgataatcaagcagcaattgctgaattagatactaaagctcaagaa
aaggttacagcagcacaacaaagtaaaaaagttacgcaagatgaagttgcagcacttgta
actaaaattaacaatgataaaaataatgcaatcgcagaaattaataaacaaactacagca
caaggtgtcacaactgaaaaagataatggtatcgcagtgttagaacaagatgtgattaca
ccaacagttaaacctcaagcgaaacaagatattatccaagcagttacaactcgtaaacaa
caaattaaaaagtcaaatgcatcattacaagatgaaaaagatgtagcaaatgataaaatt
ggtaaaattgaaacaaaggcaattaaagatattgatgcagcaacaacaaatgcacaagta
gaagccattaaaacaaaagcaatcaatgatattaatcaaactacacctgctacaacagct
aaagcagcagctcttgaagaatttgacgaagttgttcaagcacaaattgatcaagcacct
ttaaatcctgatacaacaaatgaagaagtagcggaagctattgaacgtattaatgcagct
aaagtttctggtgttaaagcaattgaagcgacaacgactgcacaagatttagaaagagtt
aaaaacgaagaaatctcaaaaattgaaaatattactgactctacgcaaacaaaaatggat
gcctataatgaagttaaacaagctgcaacagctagaaaagctcaaaatgctacagtttca
aatgcaacaaatgaagaagtagcagaagctgatgcagcagtagatgcagctcaaaagcaa
ggtttacatgacatccaagttgttaaatcaaaacaggaagttgctgatacaaaatcaaaa
gtattagataaaatcaatgcaattcaaacacaagcaaaagttaaacctgcagctgatacg
gaagtagaaaacgcatataatacacgtaaacaagaaattcaaaatagcaatgcttcaact
acagaagaaaaacaagctgcatatacagaattagatactaaaaagcaagaagcaagaaca
aatcttgatgctgcaaatacaaacagtgatgtaacaacagctaaagacaatagtattgct
gcaattaatcaagttcaagctgccacaactaagaaatcggatgcaaaagcggaaatcgct
caaaaagcaagtgaacgtaaaacagcaattgaagcaatgaatgattcgactactgaagaa
caacaagcagcgaaagacaaagtggatcaagcagtagttactgcaaacgctgatatagat
aatgctgcagcaaacaatgatgtggataatgcaaaaactacaaatgaagctacaatcgca
gccattacacctgatgcaaatgttaaaccagcagcaaaacaagcaattgcagataaagta
caagctcaagaaacagcaattgatggaaataacggctcaacaactgaagaaaaagcagct
gctaaacaacaagttcaaactgaaaaaacaacagctgatgccgcaatagatgcagcacat
acaaatgcggaagttgaagcggctaaaaaagcagcaattgctaaaattgaagcgattcag
ccagcaacaacaactaaagataatgcgaaagaagcaattgctacgaaagcgaatgaacgt
aaaacagcaatcgctcaaacgcaagacattactgctgaagaaattgcagcggctaatgcg
gacgtagataatgctgtgacacaagcaaatagcaacattgaagctgctaatagtcaaaat
gatgtagaccaagcgaaaacgacaggtgaaaatagtattgatcaagtaacaccaacagtt
aataaaaaagcaactgcacgtaatgaaatcacagcaattttaaataacaaattgcaagag
attcaagctacgccagatgcaacagatgaagaaaaacaagcagctgatgctgaagcaaat
actgaaaatggtaaagcaaatcaagccatttcagcagcaactactaacgcacaagttgat
gaagctaaagcaaatgcagaagcagcgattaatgcggtaacaccaaaagttgtgaagaaa
caagcggctaaagatgaaattgatcaattacaagcaacgcaaacaaatgttatcaataat
gatcagaacgctacaacagaagaaaaagaagcagctattcaacaattagcaacagcagtt
acagacgcgaaaaataatattacagctgcaactgatgataatggtgtagatcaggcgaaa
gacgctggaaagaattcaattcaaagcacgcaaccagcaacagcggttaaatcaaatgct
aaaaatgatgttgatcaagctgtgacaactcaaaatcaagcaattgataatacaactggt
gctacaactgaagagaaaaatgcagcaaaagatttagttttaaaagctaaagaaaaagcg
tatcaagatatcttaaatgcacaaacaactaatgatgttacgcaaattaaagatcaagca
gttgctgatattcaaggtattactgcagatacaacaattaaagatgttgcgaaagatgaa
ttagcaacaaaagcaaacgaacaaaaagcgcttattgcacaaactgcagatgcgactact
gaagaaaaagaacaagcaaatcaacaagtagacgcacaattaacacaaggtaatcaaaat
attgaaaatgcacagtcaatcgatgatgtaaacactgcaaaagataatgcaattcaagca
attgacccaattcaagcatcaacagatgttaaaacgaatgcaagagcggaattgctaact
gaaatgcaaaataaaataactgaaatacttaataataatgagactactaatgaagaaaaa
ggtaacgatattggaccagttagagcagcatatgaagaaggtttaaataatattaatgca
gcaactactacaggtgatgtaactactgctaaagatacagcagtacaaaaagttcaacaa
cttcatgcaaatcctgttaagaaaccagcaggtaaaaaagaattagatcaagctgcagct
gataagaaaacacaaatagaacaaacaccaaatgcatcacaacaagaaattaatgatgca
aaacaagaagttgatactgaattaaatcaagcgaaaacaaatgtcgatcaatcatcaaca
aatgaatatgttgataatgcagttaaagaaggaaaagctaaaattaatgcagttaaaaca
tttagtgagtacaaaaaagatgctttagctaaaattgaagatgcatataatgctaaagta
aacgaagcggataactctaacgcatcgacttcaagtgaaattgctgaagcgaaacaaaaa
cttgctgaattaaaacaaactgcggatcaaaatgttaatcaagctacttctaaagatgac
attgaagttcaaattcataatgacttagataatattaacgattacacaattccaacaggt
aaaaaagaatcagctacaacagatttatatgcttatgcagatcagaagaaaaataatatt
tcagctgacactaatgcaacacaagatgaaaagcaacaagcaattaagcaagttgaccaa
aatgttcaaactgcattagaaagcattaataatggtgtggataatggtgacgttgatgat
gcattaacacaaggtaaagcagcaattgatgctattcaagtagatgctactgttaaacct
aaagcgaaccaagctattgaagttaaagcagaagatacgaaagaatctattgatcaaagt
gaccagttaactgctgaagaaaaaactgaagcattagcaatgattaaacaaattacagat
caagctaaacaaggtattactgatgcaacaacaactgctgaagttgaaaaagcgaaagct
caaggacttgaagcatttgataacattcaaatcgactcaacagaaaaacaaaaagctatc
gaagaattagaaactgcactagaccagattgaagcaggtgtaaatgtcaacgctgatgct
acaactgaagaaaaagaagcgtttacgaatgctttagaagacattttatcaaaagcaact
gaagatatttctgatcaaactacaaatgcagaaatcgctactgtcaaaaatagtgcgctt
gaacaacttaaagcacaacgtattaatcctgaagttaagaaaaatgctttggaagcaatc
agagaagtggttaacaagcaaatagaaataattaaaaatgcagatgcagatgcatcggcg
aaagaaattgcacgtacggatttaggtagatattttgacagatttgctgataaattagat
aaaacacaaacaaatgcagaagttgctgaattacaaaatgtaacgatacctgcaattgaa
gcgattgtgcctcagaatgatccagatgctaatgatactaataatggtatagataataat
gatgcaacagcaaattcaaatgctaatgcaacaccagaaaatactggacaacctaacgta
tctgagacgacagctaatggcaaagcagacgcttctccgacaacaccaaataatagtgat
gcggcaacaggtgaaacaacagcaacatcagcaactgatgatgcaaatgataaaccgcaa
gctaataacaattctagtgtagatgcatcaacaaacagtccgacaatggataacgatgta
actagtaaaccagaagtagaatcaactaataacggcacaactgataaacctgtaacagaa
actgataatgcaacgccagcagaaagcacaacaaataacaatagtacaactacagcaaca
aacgagaatgcaccaacaggatcaacagcaacggctccaacaactgcgagcacagaagca
gcatcatctgctgatagcaaagataatgcatctgtaaatgattcaaaacaaaatgctgaa
gtaaataatagtgctgaatctcaatcaactaatgacaaggttgcacaaccaaaatctgaa
aataaagctaaggcagaaaaagatggtagtgattcaacaaatcaaagtatggttgaatca
acaactgaaacattgccttcagcagacataacagaaccaaatgtaccttctaatacatca
aaagataaagaagaaagtacgacaaatcaaactgatgcaggacaacttaagtctgaaact
aacgttgcatctaacgaagcagataaatcgccaagcaaagctgatactgaagtttcgaat
aaaccatcaacatctgcatcttctgaagcaaaagaaaaaatgacttcaactaatcttagc
caaaaagatgatacggcaacagcagatactaatgatacgcaaaaatcagttggttcagct
gcaaacaataaagctacgcaaaacgacggtgccaatgcatctccagctacagtttcaaat
ggaagcaatagtgctaatcaagatatgcttaatgtaactaacactgacgaccaccaagct
aagacaaaatcagctcaacaaggaaaagttaataaagctaaacaacaagctaaaacttta
ccagatactggtatgtcacataatgacgatttaccatatgctgaattagctctaggtgca
ggtatggcattcttaattagaagattcactaagaaagaccaacaaactgaagaa
202.
atgaaactaaaatcatttgttactgccactttagcattgggattattatcaacggtcgga
gctgcattaccgagtcacgaagcatctgcagatagtaataacggctataaagaaatgact
gtggatggttatcacactgttccttacacaatttcagtagatggtattactgcattacat
cgaacttactttatcttcccagaaaataaaaatgttctttatcaagaaattgacagtaaa
gtaaaaaatgaattagcttctcaacgtggtgttacaacagaaaaaattaataatgcccaa
acagcaacttatacgcttactttgaatgatggtaataaaaaagtagtgaatctaaagaaa
aatgacgacgctaaaaattcaattgatccaagtacaatcaaacagatacaaattgtagtt
aaa
203.
atggctattaaaaagtataagccaataacaaatggtcgtcgtaatatgacttcgttagat
ttcgcagaaatcacgaaaactacacctgaaaagtcattattaaaaccgctaccgaaaaaa
gcgggacgtaacaaccaaggtaaattgactgtaagacaccatggtggtggacacaaacgt
caataccgtgttatcgatttcaaacgtaacaaagatggtatcaatgcaaaagttgattct
attcaatatgatccaaaccgctcagcaaacatcgctttagttgtatatgcagacggtgaa
aaacgatatatcattgctcctaaaggattagaagtaggtcaaatcgttgaaagtggtgct
gaagctgacatcaaagttggtaacgcattaccattacaaaacattccagttggtacagta
gtacacaacatcgagcttaaacctggtaaaggtggacaaatcgctcgttcagctggtgca
agtgctcaagtacttggtaaagaaggtaaatacgtattaatcagattaagatctggtgaa
gttcgtatgatcttatctacttgccgtgctacaatcggtcaagttggtaacctacaacac
gaattagttaacgttggtaaagccggacgttcaagatggaaaggtatccgtccaacagtt
cgtggttctgtaatgaaccctaacgatcacccacacggtggtggtgaaggtcgtgctcct
atcggtagaccatctccaatgtcaccatggggtaaacctacgcttggtaagaaaactcgt
cgtggtaaaaaatcatcagacaaacttatcgttcgtggacgtaagaaaaaa
204.
atgttagtaaatacgtttaacccatttgataatttattattatcgtctttaattgcagca
ataccgattgtactgtttttactatgtttaactgtttttaaaatgaaaggtatttatgca
gctattacaacacttgttgtaacattactaattgcaataccatttttcaaattgccagtt
ggtatcgcttctggtgcagtagtcgaaggtttcttccaaggtatcattccgattggctat
atcgttatgatggcagtattgttatacaaaattactgttgaatctggacaatttttaaca
attcaagatagtattacaaatatttcacaagaccaacgtattcaagttttacttattgga
tttgcattcaacgcatttttagaaggtgcagcaggatttggtgtaccaattgcaatttgt
gcacttttattaacacaattaggatttaatccattaaaagctgcgatgttatgtttagtc
gcaaatgcagcgtctggtgcttttggtgcgattggtatccctgtaggtgttgtagaaacg
ttgaaattacctggagatgtttcagtattaggtgtttctcaatcagcaactttaacattg
gcaatcataaatttcattattccattcttacttatctttattattgatggttttagaggt
gttaaagaaacattaccagcaattttagtagtttcaatcacttatacacttactcaagga
ttattaactgtattcagtggacctgaattagcagatattattccaccgttattaacaatg
ttagcattagcagtattttctaaaaaattccaaccaaaacacatttatcgtgttaataaa
gatgaagaaattgaacctgcaaaagcacattctgcaaaagcagtattacatgcatggagc
ccattcattgtattaacagtcattgtaatgatttggagtgcgccattctttaaaaactta
ttcttaccaaatggtgctttatcatcattagtatttaaattcaacttacctggaacaatc
agcgaagttacgcataaaccattagtattgactttaaatattattggacaaacaggtaca
gctattttattaactattattattacaattttaatgtctaaaaaggttaactttaaagat
gcaggtagattattcggcgttacatttaaagagttgtggttaccagttcttacaatttgt
ttcatcttagcaatttctaaaatcacaacttatggtggtttaagtgcagcaatgggtcaa
ggtattgctaaagcaggtaatgtcttcccagttctatcaccaattttaggttggataggt
gtgtttatgacaggatcagttgtaaataacaactcattatttgcaccaattcaagcttct
gttgcacaacaaattggaacaagtggttcacttcttgtatctgctaatacagttggtggt
gtagcggcaaaattgatttcaccacaatcaattgcaattgcaactgcagcagtaaaacaa
gttggtaaggaatcagaattattaaaaatgacattgaaatacagtgtatgtttactaata
ttcatctgtatttggactttcatcttgtcattatta
205.
atgcttaaaaataaaatattaactacaactttatctgtgagcttacttgcccctcttgcc
aatccgttattagaaaatgctaaagctgctaacgatactgaagacatcggtaaaggaagc
gatatagaaattatcaaaaggacagaagataaaacaagtaataaatggggcgtgactcaa
aatattcaatttgattttgtaaaggataaaaaatataacaaagatgctttgatattaaag
atgcaaggattcattagctctagaacaacatattacaactataaaaaaactaatcatgtt
aaagctatgcgatggccattccaatataatattggtttaaaaacaaatgataaatatgtt
tctttaattaattatttacctaaaaataaaattgaatctacaaacgtgagtcagatatta
ggatacaatatcggtggtaatttccaatcagccccatcactcggtggtaatggatcattt
aactattctaaatcgattagctatacacaacaaaattatgtaagtgaagtagaacaacaa
aactcaaaaagtgttttatggggcgtcaaagcgaattcattcgccactgaatcaggtcaa
aaatcagcctttgatagcgatttatttgtaggctacaaacctcatagtaaagatcctaga
gattatttcgttccagacagtgagttaccacctcttgtacaaagtggatttaacccttca
tttatcgccacagtatctcatgaaaaaggttcaagcgatacaagcgaatttgaaattact
tacggaagaaacatggatgtcactcatgccattaaaagatcaacgcattatggcaacagt
tatttagacggacatagagtccataatgcatttgtaaatagaaactatactgtgaaatac
gaggtcaattggaagactcatgaaatcaaggtgaaaggacagaat
206.
atgaaaatgaataaattagtcaaatcatccgttgctacatctatggcattattattactt
tctggtactgctaatgctgaaggtaaaataacaccagtcagcgtaaaaaaagtcgatgac
aaagttactttatacaaaacaacagccacagcagattctgataaatttaaaatttcacag
attttaacatttaatttcatcaaagataaaagttatgataaagatactttagtacttaaa
gctactgggaatattaactcaggctttgtgaaacctaatcctaatgactatgacttttca
aaattatattggggagctaaatacaatgtatctataagctcacaatctaatgattcagta
aacgtcgttgattatgcaccaaaaaatcaaaatgaagagtttcaagttcaaaatacttta
ggctatacatttggtggtgacattagtatctctaatggtttatctggtggacttaatgga
aatacagctttttctgaaacaattaattataaacaagaaagttacagaacaacattaagt
cgcaacacaaattataaaaatgttggctggggagttgaagcacataaaattatgaataat
ggttggggaccttatggaagagatagcttccacccaacatatggtaatgaactcttctta
gctggcagacaaagcagtgcatacgctggccaaaacttcatagcgcaacaccaaatgcca
ttattatctagaagtaacttcaatccagaatttttaagcgtactatcacacagacaagat
ggcgctaaaaaatctaaaattacagtaacttatcaacgtgaaatggatttataccaaatt
cgttggaatggcttctactgggcaggcgcaaattataaaaactttaaaactagaacattt
aaatcaacatatgaaattgattgggaaaatcacaaagtgaaattgttagatacaaaagaa
actgaaaacaataaa
207.
atgaatagagagatgttgtatttaaatagatcagatattgaacaagcgggaggtaatcat
tcacaagtttatgtggacgcattaacagaagcattaacagcccatgcgcacaatgatttt
gtacaaccgcttaagccgtatttaagacaggatcctgaaaatggacacatcgcagatcga
attattgcaatgccaagtcatatcggtggtgaacacgcaatttcaggtattaagtggata
ggtagtaagcacgacaatccatcgaaacgtaatatggagcgtgcaagtggcgtcattatt
ttgaatgatccagaaacgaattatccaattgcagttatggaagcaagtttaattagtagt
atgcgtactgcagcagtttcagtgattgcagcaaagcatttggctaaaaaaggatttaaa
gacttaacaatcattggatgcgggctaatcggagacaagcaattacaaagtatgttagag
caattcgatcatattgaacgcgtgtttgtttacgatcaattctctgaagcatgtgcacgc
tttgttgatagatggcaacaacagcgtccggaaattaattttattgcgacagaaaatgct
aaagaagcagtatcaaatggtgaagtagtcattacatgtaccgtaacggatcaaccatac
attgaatatgattggttacaaaagggtgcatttattagcaacatttctatcatggatgtg
cataaagaagtctttattaaagctgacaaagtcgtagtagatgactggtcacaatgtaat
cgagaaaagaaaactattaaccaattggtgttagaaggtaaattcagcaaagaagctctt
catgctgaactaggacaacttgtgacaggtgacataccaggacgtgaagacgatgatgag
atcatattacttaatccgatgggtatggctatcgaagatatttcaagtgcttattttatt
tatcaacaggcacaacaacaaaatattgggacaacattgaacctatat
208.
atgaaaaaaattatggttattttcggtacgagacccgaagcaataaaaatggcaccatta
gtaaaagaaattgatcataatgggaactttgaagcgaacattgtgattacagcacaacat
agagatatgttagatagtgtgttaagtatatttgatattcaagctgatcatgatttaaat
attatgcaagatcaacaaacattagcaggccttacggcgaatgcacttgctaaacttgat
agcatcattaatgaggaacaaccggatatgattttagtacatggtgatactacaacgact
tttgtaggaagtttggcagcattttatcatcaaattccggtcggacatgtagaagctgga
cttcgaacacatcagaaatactcaccatttcctgaagagttaaatcgagtcatggtaagt
aatattgctgaattgaattttgcgccaacagtaattgcagctaaaaatttactttttgaa
aacaaagacaaagagcgtatctttattactggaaatacagttattgacgcattgtcaaca
acagttcaaaatgattttgtttcaacgattattaataaacataaaggcaagaaagttgtt
ttactaacagcgcatcgtcgtgaaaatattggggaaccgatgcatcagatttttaaagca
gtaagagatttggcagatgaatataaagatgttgtcttcatttatccaatgcatcgtaat
ccaaaggtaagagcgattgccgaaaaatatttatctgggagaaatcggattgaattaatt
gagccattagatgcgattgagttccataattttacaaatcaatcgtacctcgtgctgaca
gattctggtggtattcaagaggaggctcctacatttggaaaacctgtgttggtattaagg
aatcatacagagcgtcccgaaggcgttgaggcgggaacatcgagagtaattggcacagat
tatgacaatattgttcgaaatgtgaaacaattgattgaggatgatgaagcgtatcaacgt
atgagtcaagcgaataatccatatggtgatggacaagcatcacgacgtatttgtgaagca
atagaatattattttggattgcgcacagacaagccggatgaattcgtacctttacgtcac
aaa
209.
atgattatgggtaatttgagatttcaacaggaatattttcgtatatacaaaaataataca
gaatcaacgacacaccgtaatgcgtattgggttaaactcgctaaaaatgttgaagctact
aaaatgatgtatgcattatcgacaattgtgcaacaacatgcatctataagacattttttt
gatgttactaccgatgacaatttaacaatgatacttcatgaatttctgccttttattgag
ataaaacaagttccatcttcttccgcaaactatgatttagaagctttttttaagcaagaa
ttaagtacttaccattttaatgattcacctttattcaaagttaaattgtttcagttcgct
gatgctgcatatatactattagattttcatgtgtccattttcgatgatagtcaaattgat
atttttcttgatgatttatgcaatgcatatcgtggcaatactgttattaacaatactcga
cagcatgcacatataaatagaaatgatgataaagacaatcaagatgcatcgcatatagca
ttagactcaaactattttcggttagagaataactctgacatccatattgatagttatttt
ccaattaagcatccatttgaacaagctttatatcaaacgtatttgattgatgatatgaca
tcaatagatatggcatcgttggctgttagtgtgtatttagctaatcatataatgagtcaa
caacatgatgtcacattaggtatacatgtaccatcacatttaccaaatgatttacacgga
aatattgtgccgttaacgttaacaatcgatgcaaaagatgtatgtcaacgttttacaaca
gattttaataaatgtgtgttgcaaaatatgtcgcaattacagtgcgcgaagtcttcgctt
tcactagagactatttttcattgttatcatcatatgatgtcttgttgtaatgatgttatt
gaggatgtacatcaaatacatgatgcacatacatctttagcggatattgaaatttttcca
catcaacacgggttcaaaattatatataacagtgcagcatatgatttgctctcaatcgag
acgctgagtgacttagttcgaaatatttatttgcaaattactgaagaaaatggaaataaa
cgaacaactgtagatgaacttaatttgatgacagaacgtgatattcaattatatgacgat
atcaatttaagtttgcctgagatagatgatgcgcaaacagttgttaccttatttgagcaa
caagttgaagcaacgccgaatcatgtcgctgtgcaatttgacggagtgtttataacatat
caaacattgaatgcacgcgcgaatgatttagcacaccgtttgagaaaccagtatggtgtt
gaacctaatgatcgtgtcgctgtcatagctgaaaaaagtattgagatgataatagcgatg
ataggtgtgttgaaagctggtggggcttacgtgccaattgatccgaactatccaagtgat
cgtcaggagtacattttaaaagatgtaacgcctaaagttgtaataacgtaccaagcttta
tatgaaaatggtaaacaaaatattaatcacattgatttgaataagatagcgtggaaaaat
attgataatctttctaaatgtaacacgttagaagatcatgcttatgttatttacacgtcg
gggacaactggtaaccctaaagggacactaattccgcaccgaggtattgttcgcttggtc
catcaaaatcattatgtaccattaaatgaagagacgacgattttgttatcaggaactata
gcctttgatgctgcaacatttgaaatatatggtgcattgctcaatggtggaaagctgatt
gttgctaaaaaagaacaattattaaatccaatagcggtagaacaattaatcaatgaaaat
gacgttaatactatgtggttaacctcctcattatttaatcagattgctagtgaacgaata
gaagtattggtatcgttaaagtatttattaattggtggagaagtattgaatgctaagtgg
gtggatttgcttaatcaaaaaccgaagcatcctcaaattattaatggttatggaccaact
gaaaatacaacatttacaacgacgtataatatacctaacaaagttccaaatcgtattcct
attggtaaaccgattctgggtactcatgtttatatcatgcaaggcgagcgtcggtgtggc
gttggtattcctggagaattatgtacaagtggctttgggttagctgcaggttatttaaat
cagccagaattgacagcagataaatttatcaaagattcaaatataaatcagctgatgtat
agaagtggtgatatcgttcgtttgttacccgatggcaacatagattatttatatcgaaag
gacaaacaagttaagattcgagggtttaggattgagttgtcagaggttgagcatgcgctc
gagcgtatacaaggtattaataaagcagttgttattgttcaaaatcatgatcaagatcag
tatatcgttgcttattatgaagcgatgcatacattatcacataataagattaaatcacaa
ttacgtatgaccttaccggagtacatgataccagttaatttcatgcatattgagcaaatt
cctattactattaatgggaaattagataagaaggcattgcctatcatggactatgtcgat
acggatgcctatgtagcaccgagtacagataccgaacacttgctatgccaaatttttgca
gatattttacatgtgaatcaagtaggtattcatgataatttctttgaattaggtggccat
tcattaaaagcaacgttagtggtgaatcggatagaggcatctactgggaaacgattacaa
attggtgatttattacaaaagccaactgtatttgaactagcacaagcgattgctaaggtt
caagaacaaaactatgaagtgattccagaaactatagttaaagatgattatgtgctgagc
tctgcacaaaagcgtatgtatttattatggaaatcaaaccataaagatacggtgtataac
gtaccttttttatggcggttatcatcagaacttaatgtagctcaattgcgacaagcagtg
cagcgtttgatagcgcgacatgagattttacgaacacaatatattgttgtagatgatgag
gttcgacaacgtattgtggcagatgttgcagttgactttgaagaagttaacacgcatttt
acggatgaacaagaaatcatgcgccaatttgtagcaccttttaatttggaaaagccaagt
caaattagagtgagatacattagaagtcccttacatgcatacctctttatagatacgcat
catatcattaatgacggtatgagtaatatacaattaatgaatgatcttaacgcactttat
caacataaattattgttaccacttaaattgcaatataaagactatagtgagtggatgtcg
catcgtgatatgacgaaacatagacaatattggttatctcaattcaaagatgaagtacct
attttaagcttaccgacagactatgttagaccaaatattaaaacgacaaatggagcaatg
atgtcatttacaatgaatcaacaaatgagacagctacttcaaaagtatgtagaaaagcat
caaattactgattttatgttctttatgagtgtggtcatgacgttgttaagtagatatgct
cgaaaagatgatgttgttgtcggtagtgtgatgagtgcgcgtatgcataaaggcacggag
caaatgctaggcatgtttgctaatacgttggtatatagagggcaaccgtcacctgataaa
atgtggacacagtttttacaagaggttaaggaaatgagtttggaggcatacgagcatcaa
gaatacccattcgaatgtttagtaaatgacttagatcaatcacatgatgcctcacggaat
ccattatttgatgtcatgttagtactacaaaacaatgaaacgaatcatgctcattttggg
catagtaaattaacacacattcaacccaaatcagtgacggcgaaatttgatttatctttc
atcattgaagaagatcgcgatgactatacaatcaatatcgagtataataccgatttatat
cactcagaaacagttcgtcacatgggtaatcaatgtatgattatgattgattatattttg
aagcatcaagatacactacaaatttgtgatataccaaacggcacggaggaacttctaaat
tgggtcaatacgcatgttaacgatcgaatgcttaatgtcccgggaaataaatctatcata
agttactttaatgaagttgtctcacgacaaggtaatcatgttgcgctagtcatgaatgat
ttgacaatgacgtatgaaacattacgcaactatgtggatgccattgcgcacatgctccta
tcaaatggtgtgggcaatggtcaacgggttgccttgtttacagaacgtagttttgaaatg
attgcggcgatgttggcgacagttaaagtaggtgcatcttatatacctatcgatattgat
tttccgaataaacgacaaggtgcaattttggaggatgctaaagtaactgcagtcatgtct
tacggcgttgaaattgaaacgacattaccagtcattcaattggaaaatgctaaaggcttt
gttgaatcaaaggaaaatgaacaatatgatgatttacatggcaatcaacttgaaaacaca
gcgatgttagataatgagatgtatgctatttacacatctggtacgaccgggatgcctaaa
ggggttgccatacgacaacgaaatttgttgaatttagtgcatgcatggtcaactgaattg
caattaggcgacaatgaagtatttttgcaacatgcaaatattgtttttgatgcatcagtt
atggagatttattgttgtttgttaaatggtcatacgcttgtgattccagatagagaggaa
cgtgttaatccagaacagttacaacaactcattaataagcatcgtgtgacggttgcgtcg
attccgttacagatgtgtagtgttatggaagacttttatattgaaaagttgattacaggc
ggggcaactagtacggcatcctttgttaaatatattgagaagcattgtggcacgtatttc
aatgcctatggaccatctgagtcaacagtcatcacatcgtattggtcacatcattgtggt
gatttgatacctgagacgattccaattggcaaacccttatctaacatccaagtgtatatt
atgtcagatggtttgttatgcggtattggtatgccaggcgagttgtgtattgcaggtgat
agtttagcgataggatatattaatcgtccagaattaatggctgataaatggcaaaataat
ccatttggtaaaggaaagttgtatcatagtggtgatttagcacgttatacatctgatggt
caaattgaatttttaggaagaatagataaacaagtgaaagttaacgggtaccgtattgaa
cttgatgaaattgaaaatgcaatattagctattcgtggtatatctgattgtgttgtaaca
gtaagtcactttgatacgcatgatatattgaatgcttattatgtcggagagcaacaagtg
gaacaggatttgaagcaatatttaaatgatcagctgcctaagtatatgattcctaagact
ataacgcatatcgattgtatgccattaaccacgaatgacaaggtggatactacgcgtttg
ccaaatccatcacctatacaacagtctaataaagtgtatagcgaaccctctaatgaaatt
gagcagacatttgttgatgtatttggagaggtattgaaacaaaatgatgtcggtgttgac
gatgatttctttgaacttggtggtaactcattagaggcgatgttagttgtctcgcattta
aaacgatttggccatcatatttcaatgcagacattataccaatataaaaccgtgcgacag
attgttaattatatgtaccaaaatcaacaatcattagttgcattaccggataatctttcg
gaattacaaaagattgttatgtctcgttataacttgggtattttagaggatagtctaagt
catcgacctctaggaaatacactattgactggcgcgacaggttttttaggtgcttatctg
attgaagtactacaaggatacagtcatcgcatttattgtttcatacgtgctgataatgag
gaaatagcatggtataagttgatgacgaatttaaatgattatttttcagaagagacggtt
gaaataatgttatcaaacattgaagtcattgttggtgatttcgagtgtatggatgatgtt
gttttaccagaaaacatggatacgattattcatgcaggtgctcgtacagatcactttggt
gatgatgatgaatttgaaaaagtaaatgttcaaggtactgttgatgtcatacgtttggca
caacaacatcatgcaaggttaatatatgtgtctacgataagtgtgggaacttattttgat
atagacacagaagatgtgacattttcagaagcggatgtctataaagggcaactactaaca
tcaccatatacacggagcaaattttatagtgaattaaaagtattagaagctgtaaataat
ggcttagatggtcggattgtacgtgttggtaatttgacgaatccttacaatggaagatgg
catatgagaaatataaagactaaccgtttttcaatggtaatgaatgatttgttacaactg
gattgtatcggggttagcatggctgaaatgcctgtagatttttcttttgtggatacgact
gcaagacaaattgtcgcattagcacaggtcaacacaccacaaatcatttaccatgtgcta
tcacctaataaaatgccggtgaaatctttgttagaatgcgttaagcgcaaagaaattgaa
ctcgtcagcgatgaatcatttaatgaaattttacagaaacaagacatgtacgaaacgatt
ggattaactagtgttgaccgtgaacaacaactagcaatgatagatacaacattaacatta
aaaataatgaatcacatcagtgaaaaatggccaacgataactaacaattggctgtatcat
tgggcacaatatatcaaaacaatattcaataag
210.
atgaccaaagaacaacaacttgcagaacgaattattgctgcagtaggtggtatggataat
atagatagtgtcatgaactgtatgacacgtgtgcgtattaaagtattagatgagaataaa
gtagatgaccaagaactaaggcatattgatggtgtcatgggtgttatacacgatgaacgc
attcaagttgtggttggacctggtacagtcaataaagtggctaatcatatggcggaatta
agtggtgttaaactaggtgacccaataccacaccatcacaatgatagtgaaaaaatggac
tataaatcatatgcagctgataaagcaaaggcgaataaggaagcgcataaagcaaaacaa
aagaatggtaagttgaataaagtattgaaatcaattgccaatatctttataccgttgatt
cctgcatttattggagctggattaattggtggtattgcagcagtactgagtaacttaatg
gtggcaggctatatttcaggtgcttggattacgcaacttataacagtatttaatgtcatt
aaagacggtatgttagcatacttagctattttcactggtattaatgcggctaaagaattt
ggtgcgacaccaggacttggtggcgtgattggtggtacaacgttattaacgggtattgct
ggtaaaaatattttaatgaatgtcttcactggagaaccattgcaacctggacaaggtggg
attattggcgttatttttgccgtttggattttaagtattgtcgaaaagagattacataaa
attgtgccaaatgcgattgatattattgtaacgccgactattgcattgttgattgtagga
ctattaactatctttatctttatgccattagcaggttttgtttcagacagtttagtttca
gtagttaacggaattattagtattggtggcgtatttagtggatttatcattggtgcaagc
ttcctaccgttagttatgttagggcttcatcatatttttacgccaattcatatagaaatg
attaaccaatcaggtgctacttacttattgccaattgcagcgatggctggtgctggacaa
gtaggtgccgcattagcactttgggtaagatgtaaacgcaacacaacattacgtaatact
ttaaaaggtgcattgccagttggtttcctaggtatcggagaaccattaatctatggtgtg
actttgccattaggtcgacctttcttaactgcttgtattggtggtggtattggtggcgct
gtaataggtggaattggacatattggtgccaaagcaataggcccaagtggtgtgtcacta
ttaccattaatctcagataatatgtatttaggttatattgcaggattacttgctgcgtat
gctggtggattcgtttgtacatatttatttggaacgacaaaggcgatgcgacagacagat
ttgttgggtgat
211.
atgtctaaaattttaaaatgtatcacgttagccgtggtaatgttattaatcgtaactgca
tgtggccctaatcgttcgaaagaagatattgataaagcattgaataaagataattctaaa
gacaagcctaaccaacttacgatgtgggtggatggcgacaagcaaatggcgttttataaa
aaaattacggatcaatatactaaaaaaactggcatcaaagtaaagcttgtaaatattggt
caaaatgatcaactagaaaatatttcgctagacgctcctgcaggaaaaggtccagatatc
tttttcttagcacatgataatactggaagtgcctatctacaaggcttagctgctgaaatc
aaattatcaaaagatgagttgaaaggtttcaataagcaagcacttaaagcgatgaattat
gacaataagcaactagcattgccagctatcgttgaaacaaccgcacttttttataataaa
aaattagtgaaaaatgcaccgcaaacgttagaagaagttgaagctaatgctgccaaacta
actgatagtaaaaagaaacaatacggtatgttatttgatgctaaaaatttctattttaat
tatccgtttttattcggcaatgatgattatattttcaagaaaaatggcagtgaatatgat
attcatcagctaggactaaattcaaaacatgtcgtcaagaatgctgaacgattacaaaaa
tggtacgacaaagggtatcttcctaaggcagcaacacatgatgtcatgattggtcttttt
aaagaaggaaaagtaggacaatttgtcactggaccgtggaacattaatgaatatcaagaa
acgtttggtaaagatttaggagtaacaacattacctacagatggtggcaaacctatgaaa
ccatttctaggtgtacgtggttggtatttatctgaatatagtaaacataagtattgggct
aaagatttaatgctgtatatcactagtaaagatacattacaaaaatatacagatgaaatg
agcgaaattactggacgtgttgacgtgaaatcatctaatccaaatttaaaagtgtttgaa
aagcaagcacgtcatgctgaaccgatgcctaatattcctgaaatgcgacaagtttgggaa
ccgatgggcaatgcaagcatatttatttcaaatggtaagaatcctaaacaagcgttagat
gaggcgacgaatgatataacgcaaaatattaagattcttcatccatcacaaaatgataag
aaaggagat
212.
gtgaaagcattgaaattatatggcgtggaagatttacggtatgaggataatgaaaagcca
gtcattgaaagtgcgaatgacgttattattaaagtacgagcgactggcatatgtggttca
gacacgtcacgatacaaaaaaatggggccatacattaaaggtatgccatttggtcatgaa
ttttcaggtgtagtagatgccattggaagtgatgttacgcatgttaatgtgggcgacaaa
gtgacaggttgcccagcaataccttgttatcaatgcgagtattgtttaaaaggtgaatat
gcacgatgtgaaaagttattcgtcattggctcatatgaacctggatcgttcgcggaatat
gtcaaattgccagcgcaaaatgttttaaaggttccagacaatgttgattacattgaagca
gcaatggttgagccatcagccgttgttgcgcatgggttttataaatcgaatatacaacct
ggtatgactgttgcagtaatggggtgtggcagtataggtttgttagctattcaatgggca
cgaatatttggtgctgcacatatcatcgctatagatatagatgcgcataaactagatatt
gcaacatcattgggcgcacatcaaacaatcaattcaaaagaagaaaatcttgagaaattc
atcgaaaatcattacgccaatcaaatcgatttagctatagaatcatcaggtgctaaagtt
acgattggtcaaatattgacgctacctaaaaaaggtggcgaggtggtattactcggaata
ccatatgatgatattgagattgatcgcgttcattttgaaaaaattctgcgtaacgagttg
acagtatgtggctcttggaactgtttgtccagtaattttccgggcaaagagtggacggca
accttacattatatgaagacgaaagatattaatgtaaagcctattatttctcatttttta
ccgttagaaaaaggcccggagacatttgataaattagttaacaagaaagaacgatttgat
aaagtcatgtttacgatttat
213.
atgcaagcattacaaacatttaattttaaagagctaccagtaagaacagtagaaattgaa
aacgaaccttattttgtaggaaaagatattgctgagattttaggatatgcaagatcagac
aatgccattagaaatcatgttgatagcgaggacaagctgacgcaccaatttagtgcatca
ggtcaaaacagaaatatgatcattatcaacgaatcaggattatacagtctaatcttcgat
gcttctaaacaaagcaaaaacgaaaaaatcagagaaaccgctcggaaattcaaacgatgg
gtaacatcagatgtcctaccagctattcgcaaacacggtatatacgcaacagacaatgta
attgaacaaacattaaaagatccagactacatcattacagtgttgactgagtataagaaa
gaaaaagagcaaaacttacttttacaacaagaaatcggagaactaaaacccaaagcagac
tatgtagatgaaatcttaaagtcaactggcacattagccacaactcaaatcgcggcagac
tacggtatatcagcacaaaagttaaacaaactactacacgaagctagactacaacgaaaa
gtaaataaacagtgggtgctttactcagaacacatgggcaagagttacacagaatcagac
actatagcaattgtacgctctgacggtagagaagacacagttttacaaactagatggaca
caaaaaggcagattgaaaatacatgaaatcatgactgaattcggttatgaagctaattta
gggggagcg
214.
atgaaattaaaatcattagcagtgttatcaatgtcagcggtggtgcttactgcatgtggc
aatgatactccaaaagatgaaacaaaatcaacagagtcaaatactaatcaagacactaat
acaacaaaagatgttattgctttaaaagatgttaaaacaagcccagaagatgctgtgaaa
aaagctgaagaaacttacaaaggccaaaagttgaaaggaatttcatttgaaaattctaat
ggtgaatgggcttataaagtgacgcaacaaaaatctggtgaagagtcagaagtacttgtt
gctgataaaaataaaaaagtgattaacaaaaagactgaaaaagaagatacaatgaatgaa
aatgataactttaaatatagcgatgctatagattacaaaaaagccattaaagaaggacaa
aaagaatttgatggtgatattaaagaatggtcacttgaaaaagatgatggcaaacttgtt
tacaatatcgatttgaaaaaaggtaataaaaaacaagaagttactgttgatgctaagaac
ggtaaagtattaaagagtgagcaagatcac
215.
atgaaaatgaaaaatattgcaaaaataagtttgttattaggaatattagcaacaggtgta
aacactacaacggaaaaaccagttcatgccgaaaagaaacctattgtaataagtgaaaat
agcaaaaaattaaaagcttattataatcaacctagtattgaatataaaaatgtgacaggt
tatatcagtttcattcaaccaagtattaaatttatgaatatcatagatggtaattctgtt
aataatattgctttaattggcaaagataagcaacattatcatacgggtgtacatcgtaat
cttaatatattttacgttaatgaggataagagatttgaaggtgcaaagtactctattggg
ggtatcacgagtgcaaacgataaagctgtcgacctaatagcagaagcaagagttattaaa
gaagatcatactggtgaatatgattatgactttttcccatttaaaatagataaagaagcg
atgtcattgaaagagattgattttaaattaagaaaataccttattgataattatggtctt
tacggtgaaatgagtacaggaaaaattacagtcaaaaagaaatactatggaaagtataca
tttgaattggataaaaagttacaagaagaccgtatgtccgatgttatcaatgtcacagat
attgatagaattgaaatcaaagttataaaagca
216.
mrktkivctigpaseseemieklinagmnvarlnfshgsheehkgridtirkvakrldki
vailldtkgpeirthnmkdgiielergnevivsmnevegtpekfsvtyenlindvqvgsy
illddglielqvkdidhakkevkcdilnsgelknkkgvnlpgvrvslpgitekdaedirf
gikenvdfiaasfvrrpsdvleireileeqkanisvfpkienqegidniaeilevsdglm
vargdmgveippekvpmvqkdlirqcnklgkpvitatqmldsmqrnpratraeasdvana
iydgtdavmlsgetaaglypeeavktmrniavsaeaaqdykkllsdrtklvetslvnaig
isvahtalnlnvkaivaatesgstartiskyrphsdiiavtpseetarqcsivwgvqpvv
kkgrkstdallnnavatavetgrvsngdliiitagvptgetgttnmmkihlvgdeiangq
gigrgsvvgttlvaetvkdlegkdlsdkvivtnsidetfvpyvekalgliteengitsps
aivglekgiptvvgvekavknisnnmlvtidaaqgkifegyanvl
217.
mqfdnidsalmalkngepiivvddenrenegdlvavtewmndntinfmakearglicapv
skdiaqrldlvqmvddnsdifgtqftvsidhvdtttgisayertltakklidpsseakdf
nrpghlfplvaqdkgvlarnghteaavdlakltgakpagviceimnddgtmakgqdlqkf
kekhqlkmitiddlieyrkklepeiefkakvkmptdfgtfdmygfkatytdeeivvltkg
airqhenvrlhsacltgdifhsqrcdcgaqlessmkyinehggmiiylpqegrgigllnk
lrayelieqgydtvtanlalgfdedlrdyhiaaqilkyfniehinllsnnpskfeglkqy
gidiaerievivpetvhnhdymetkkikmghli
218.
mkmkklvkssvassiallllsntvdaaqhitpvsekkvddkitlykttatsdndklnisq
iltfnfikdksydkdtlvlkaagninsgykkpnpkdynysqfywggkynvsvssesndav
nvvdyapknqneefqvqqtlgysyggdinisnglsgglngsksfsetinykqesyrttid
rktnhksigwgveahkimnngwgpygrdsydptygnelflggrqsssnagqnflpthqmp
llargnfnpefisvlshkqndtkkskikvtyqremdrytnqwnrlhwvgnnyknqntvtf
tstyevdwqnhtvkligtdsketnpgv
219.
mkkkallplflgimvflagcdyskpekrsgffyntfvdpmknvldwlgnnllndnyglai
iilvlviriillpfmlsnyknshmmrqkmkvakpevekiqekvkrartqeekmaanqelm
qvykkydmnpiksmlgclpmliqlpiimglyfvlkdqlvdglfkyphflwfdlgrpdiwi
tiiagvlyfiqayvssktmpdeqrqmgymmmvispimiiwislssasalglywsvsaafl
vvqthfaniyyekvakkevqpfieayerehnggsnkkgkntqvvskkkkk
220.
mnlfrqqkfsirkfnvgifsaliatvtfistnpttasaaeqnqpaqnqpaqpadantqpn
anagaqanptaqpaapanqgqpavqpanqggqanpaggaaqpntqpagqgnqadpnnaaq
aqpgnqatpanqagqgnnqatpnnnatpanqtqpanapaaaqpaapvaanaqtqdpnasn
tgegsinttltfddpaistdenrqdptvtvtdkvngyslinngkigfvnselrrsdmfdk
nnpqnyqakgnvaalgrvnandstdhgnfngisktvnvkpdseliinfttmqtnskqgat
nlvikdakkntelatvnvaktgtahlfkvptdadrldlqfipdntavadasrittnkdgy
kyysfidnvglfsgshlyvknrdlapkatnnkeytinteignngnfgaslkadqfkyevt
lpqgvtyvnnsltttfpngnedstvlknmtvnydqnankvtftsqgvttargthtkevlf
pdkslklsykvnvanidtpknidfnekltyrtasdvvinnaqpevtltadpfsvavemnk
dalqqqvnsqvdnshyttasiaeynklkqqadtilnedanhvktanrasqadidglvtkl
qaalidnqaaiaeldtkaqekvtaaqqskkvtqdevaalvtkinndknnaiaeinkqtta
qgvttekdngiavleqdvitptvkpqakqdiiqavttrkqqikksnaslqdekdvandki
gkietkaikdidaattnaqveaiktkaindinqttpattakaaaleefdevvqaqidqap
lnpdttneevaeaierinaakvsgvkaieatttaqdlervkneeiskienitdstqtkmd
aynevkqaatarkaqnatvsnatneevaeadaavdaaqkqglhdiqvvkskqevadtksk
vldkinaiqtqakvkpaadtevenayntrkqeiqnsnastteekqaayteldtkkqeart
nldaantnsdvttakdnsiaainqvqaattkksdakaeiaqkaserktaieamndsttee
qqaakdkvdqavvtanadidnaaanndvdnakttneatiaaitpdanvkpaakqaiadkv
qaqetaidgnngstteekaaakqqvqtekttadaaidaahtnaeveaakkaaiakieaiq
patttkdnakeaiatkanerktaiaqtqditaeeiaaanadvdnavtqansnieaansqn
dvdqakttgensidqvtptvnkkatarneitailnnklqeiqatpdatdeekqaadaean
tengkanqaisaattnaqvdeakanaeaainavtpkvvkkqaakdeidqlqatqtnvinn
dqnatteekeaaiqqlatavtdaknnitaatddngvdqakdagknsiqstqpatavksna
kndvdqavttqnqaidnttgatteeknaakdlvlkakekayqdilnaqttndvtqikdqa
vadiqgitadttikdvakdelatkaneqkaliaqtadatteekeqanqqvdaqltqgnqn
ienaqsiddvntakdnaiqaidpiqastdvktnaraelltemqnkiteilnnnettneek
gndigpvraayeeglnninaatttgdvttakdtavqkvqqlhanpvkkpagkkeldqaaa
dkktqieqtpnasqqeindakqevdtelnqaktnvdqsstneyvdnavkegkakinavkt
fseykkdalakiedaynakvneadnsnastsseiaeakqklaelkqtadqnvnqatskdd
ievqihndldnindytiptgkkesattdlyayadqkknnisadtnatqdekqqaikqvdq
nvqtalesinngvdngdvddaltqgkaaidaiqvdatvkpkanqaievkaedtkesidqs
dqltaeektealamikqitdqakqgitdatttaevekakaqgleafdniqidstekqkai
eeletaldqieagvnvnadatteekeaftnaledilskatedisdqttnaeiatvknsal
eqlkaqrinpevkknaleairevvnkqieiiknadadasakeiartdlgryfdrfadkld
ktqtnaevaelqnvtipaieaivpqndpdandtnngidnndatansnanatpentgqpnv
settangkadaspttpnnsdaatgettatsatddandkpqannnssvdastnsptmdndv
tskpevestnngttdkpvtetdnatpaesttnnnstttatnenaptgstatapttastea
assadskdnasvndskqnaevnnsaesqstndkvaqpksenkakaekdgsdstnqsmves
ttetlpsaditepnvpsntskdkeesttnqtdagqlksetnvasneadkspskadtevsn
kpstsasseakekmtstnlsqkddtatadtndtqksvgsaannkatqndganaspatvsn
gsnsanqdmlnvtntddhqaktksaqqgkvnkakqqaktlpdtgmshnddlpyaelalga
gmaflirrftkkdqqtee
221.
mklksfvtatlalgllstvgaalpsheasadsnngykemtvdgyhtvpytisvdgitalh
rtyfifpenknvlyqeidskvknelasqrgvttekinnaqtatytltlndgnkkvvnlkk
nddaknsidpstikqiqivvk
222.
maikkykpitngrrnmtsldfaeitkttpeksllkplpkkagrnnqgkltvrhhggghkr
qyrvidfkrnkdginakvdsiqydpnrsanialvvyadgekryiiapkglevgqivesga
eadikvgnalplqnipvgtvvhnielkpgkggqiarsagasaqvlgkegkyvlirlrsge
vrmilstcratigqvgnlqhelvnvgkagrsrwkgirptvrgsvmnpndhphgggegrap
igrpspmspwgkptlgkktrrgkkssdklivrgrkkk
223.
mlvntfnpfdnlllssliaaipivlfllcltvfkmkgiyaaittlvvtlliaipffklpv
giasgavvegffqgiipigyivmmavllykitvesgqfltiqdsitnisqdqriqvllig
fafnaflegaagfgvpiaicallltqlgfnplkaamlclvanaasgafgaigipvgvvet
lklpgdvsvlgvsqsatltlaiinfiipfllifiidgfrgvketlpailvvsitytltqg
lltvfsgpeladiipplltmlalavfskkfqpkhiyrvnkdeeiepakahsakavlhaws
pfivltvivmiwsapffknlflpngalsslvfkfnlpgtisevthkplvltlniigqtgt
ailltiiitilmskkvnfkdagrlfgvtfkelwlpvlticfilaiskittygglsaamgq
giakagnvfpvlspilgwigvfmtgsvvnnnslfapiqasvaqqigtsgsllvsantvgg
vaaklispqsiaiataavkqvgkesellkmtlkysvcllificiwtfilsll
224.
mlknkiltttlsvsllaplanpllenakaandtedigkgsdieiikrtedktsnkwgvtq
niqfdfvkdkkynkdalilkmqgfissrttyynykktnhvkamrwpfqyniglktndkyv
slinylpknkiestnvsqilgyniggnfqsapslggngsfnysksisytqqnyvseveqq
nsksvlwgvkansfatesgqksafdsdlfvgykphskdprdyfvpdselpplvqsgfnps
fiatvshekgssdtsefeitygrnmdvthaikrsthygnsyldghrvhnafvnrnytvky
evnwktheikvkgqn
225.
mkmnklvkssvatsmallllsgtanaegkitpvsvkkvddkvtlykttatadsdkfkisq
iltfnfikdksydkdtlvlkatgninsgfvkpnpndydfsklywgakynvsissqsndsv
nvvdyapknqneefqvqntlgytfggdisisnglsgglngntafsetinykqesyrttls
rntnyknvgwgveahkimnngwgpygrdsfhptygnelflagrqssayagqnfiaqhqmp
llsrsnfnpeflsvlshrqdgakkskitvtyqremdlyqirwngfywaganyknfktrtf
kstyeidwenhkvklldtketennk
226.
mnremlylnrsdieqaggnhsqvyvdaltealtahahndfvqplkpylrqdpenghiadr
iiampshiggehaisgikwigskhdnpskrnmerasgviilndpetnypiavmeasliss
mrtaavsviaakhlakkgfkdltiigcgligdkqlqsmleqfdhiervfvydqfseacar
fvdrwqqqrpeinfiatenakeavsngevvitctvtdqpyieydwlqkgafisnisimdv
hkevfikadkvvvddwsqcnrekktinqlvlegkfskealhaelgqlvtgdipgreddde
iillnpmgmaiedissayfiyqqaqqqnigttlnly
227.
mkkimvifgtrpeaikmaplvkeidhngnfeanivitaqhrdmldsvlsifdiqadhdln
imqdqqtlagltanalakldsiineeqpdmilvhgdttttfvgslaafyhqipvghveag
lrthqkyspfpeelnrvmvsniaelnfaptviaaknllfenkdkerifitgntvidalst
tvqndfvstiinkhkgkkvvlltahrrenigepmhqifkavrdladeykdvvfiypmhrn
pkvraiaekylsgrnrieliepldaiefhnftnqsylvltdsggiqeeaptfgkpvlvlr
nhterpegveagtsrvigtdydnivrnvkqlieddeayqrmsqannpygdgqasrricea
ieyyfglrtdkpdefvplrhk
228.
mimgnlrfqqeyfriyknntestthrnaywvklaknveatkmmyalstivqqhasirhff
dvttddnltmilheflpfieikqvpsssanydleaffkqelstyhfndsplfkvklfqfa
daayilldfhvsifddsqidiflddlcnayrgntvinntrqhahinrnddkdnqdashia
ldsnyfrlennsdihidsyfpikhpfeqalyqtyliddmtsidmaslavsvylanhimsq
qhdvtlgihvpshlpndlhgnivpltltidakdvcqrfttdfnkcvlqnmsqlqcakssl
sletifhcyhhmmsccndviedvhqihdahtsladieifphqhgfkiiynsaaydllsie
tlsdlvrniylqiteengnkrttvdelnlmterdiqlyddinlslpeiddaqtvvtlfeq
qveatpnhvavqfdgvfityqtlnarandlahrlrnqygvepndrvaviaeksiemiiam
igvlkaggayvpidpnypsdrqeyilkdvtpkvvityqalyengkqninhidlnkiawkn
idnlskcntledhayviytsgttgnpkgtliphrgivrlvhqnhyvplneettillsgti
afdaatfeiygallnggklivakkeqllnpiaveqlinendvntmwltsslfnqiaseri
evlvslkylliggevlnakwvdllnqkpkhpqiingygptenttftttynipnkvpnrip
igkpilgthvyimqgerrcgvgipgelctsgfglaagylnqpeltadkfikdsninqlmy
rsgdivrllpdgnidylyrkdkqvkirgfrielsevehaleriqginkavvivqnhdqdq
yivayyeamhtlshnkiksqlrmtlpeymipvnfmhieqipitingkldkkalpimdyvd
tdayvapstdtehllcqifadilhvnqvgihdnffelgghslkatlvvnrieastgkrlq
igdllqkptvfelaqaiakvqeqnyevipetivkddyvlssaqkrmyllwksnhkdtvyn
vpflwrlsselnvaqlrqavqrliarheilrtqyivvddevrqrivadvavdfeevnthf
tdeqeimrqfvapfnlekpsqirvryirsplhaylfidthhiindgmsniqlmndlnaly
qhklllplklqykdysewmshrdmtkhrqywlsqfkdevpilslptdyvrpnikttngam
msftmnqqmrqllqkyvekhqitdfmffmsvvmtllsryarkddvvvgsvmsarmhkgte
qmlgmfantlvyrgqpspdkmwtqflqevkemsleayehqeypfeclvndldqshdasrn
plfdvmlvlqnnetnhahfghsklthiqpksvtakfdlsfiieedrddytinieyntdly
hsetvrhmgnqcmimidyilkhqdtlqicdipngteellnwvnthvndrmlnvpgnksii
syfnevvsrqgnhvalvmndltmtyetlrnyvdaiahmllsngvgngqrvalftersfem
iaamlatvkvgasyipididfpnkrqgailedakvtavmsygveiettlpviqlenakgf
veskeneqyddlhgnqlentamldnemyaiytsgttgmpkgvairqrnllnlvhawstel
qlgdnevflqhanivfdasvmeiyccllnghtlvipdreervnpeqlqqlinkhrvtvas
iplqmcsvmedfyieklitggatstasfvkyiekhcgtyfnaygpsestvitsywshhcg
dlipetipigkplsniqvyimsdgllcgigmpgelciagdslaigyinrpelmadkwqnn
pfgkgklyhsgdlarytsdgqieflgridkqvkvngyrieldeienailairgisdcvvt
vshfdthdilnayyvgeqqveqdlkqylndqlpkymipktithidcmplttndkvdttrl
pnpspiqqsnkvysepsneieqtfvdvfgevlkqndvgvdddffelggnsleamlvvshl
krfghhismqtlyqyktvrqivnymyqnqqslvalpdnlselqkivmsrynlgiledsls
hrplgntlltgatgflgaylievlqgyshriycfiradneeiawyklmtnlndyfseetv
eimlsnievivgdfecmddvvlpenmdtiihagartdhfgdddefekvnvqgtvdvirla
qqhharliyvstisvgtyfdidtedvtfseadvykgqlltspytrskfyselkvleavnn
gldgrivrvgnltnpyngrwhmrniktnrfsmvmndllqldcigvsmaempvdfsfvdtt
arqivalaqvntpqiiyhvlspnkmpvksllecvkrkeielvsdesfneilqkqdmyeti
gltsvdreqqlamidttltlkimnhisekwptitnnwlyhwaqyiktifnk
229.
mtkeqqlaeriiaavggmdnidsvmncmtrvrikvldenkvddqelrhidgvmgvihder
iqvvvgpgtvnkvanhmaelsgvklgdpiphhhndsekmdyksyaadkakankeahkakq
kngklnkvlksianifiplipafigagliggiaavlsnlmvagyisgawitqlitvfnvi
kdgmlaylaiftginaakefgatpglggviggttlltgiagknilmnvftgeplqpgqgg
iigvifavwilsivekrlhkivpnaidiivtptiallivglltififmplagfvsdslvs
vvngiisiggvfsgfiigasflplvmlglhhiftpihieminqsgatyllpiaamagagq
vgaalalwvrckrnttlrntlkgalpvgflgigepliygvtlplgrpfltacigggigga
viggighigakaigpsgvsllplisdnmylgyiagllaayaggfvctylfgttkamrqtd
llgd
230.
mskilkcitlavvmllivtacgpnrskedidkalnkdnskdkpnqltmwvdgdkqmafyk
kitdqytkktgikvklvnigqndqlenisldapagkgpdifflahdntgsaylqglaaei
klskdelkgfnkqalkamnydnkqlalpaivettalfynkklvknapqtleeveanaakl
tdskkkqygmlfdaknfyfnypflfgnddyifkkngseydihqlglnskhvvknaerlqk
wydkgylpkaathdvmiglfkegkvgqfvtgpwnineyqetfgkdlgvttlptdggkpmk
pflgvrgwylseyskhkywakdlmlyitskdtlqkytdemseitgrvdvkssnpnlkvfe
kqarhaepmpnipemrqvwepmgnasifisngknpkqaldeatnditqnikilhpsqndk
kgd
231.
vkalklygvedlryednekpviesandviikvratgicgsdtsrykkmgpyikgmpfghe
fsgvvdaigsdvthvnvgdkvtgcpaipcyqceyclkgeyarceklfvigsyepgsfaey
vklpaqnvlkvpdnvdyieaamvepsavvahgfyksniqpgmtvavmgcgsigllaiqwa
rifgaahiiaididahkldiatslgahqtinskeenlekfienhyanqidlaiessgakv
tigqiltlpkkggevvllgipyddieidrvhfekilrneltvcgswnclssnfpgkewta
tlhymktkdinvkpiishflplekgpetfdklvnkkerfdkvmftiy
232.
mqalqtfnfkelpvrtveienepyfvgkdiaeilgyarsdnairnhvdsedklthqfsas
gqnrnmiiinesglyslifdaskqsknekiretarkfkrwvtsdvlpairkhgiyatdnv
ieqtlkdpdyiitvlteykkekeqnlllqqeigelkpkadyvdeilkstgtlattqiaad
ygisaqklnkllhearlqrkvnkqwvlysehmgksytesdtiaivrsdgredtvlqtrwt
qkgrlkiheimtefgyeanlgga
233.
mklkslavlsmsavvltacgndtpkdetkstesntnqdtnttkdvialkdvktspedavk
kaeetykgqklkgisfensngewaykvtqqksgeesevlvadknkkvinkktekedtmne
ndnfkysdaidykkaikegqkefdgdikewslekddgklvynidlkkgnkkqevtvdakn
gkvlkseqdh
234.
mkmkniakislllgilatgvntttekpvhaekkpivisenskklkayynqpsieyknvtg
yisfiqpsikfmniidgnsvnnialigkdkqhyhtgvhrnlnifyvnedkrfegakysig
gitsandkavdliaearvikedhtgeydydffpfkidkeamslkeidfklrkylidnygl
ygemstgkitvkkkyygkytfeldkklqedrmsdvinvtdidrieikvika
235.
Ttgaaaaatattttaaaagtttttaatacaacgattttagcgttaattatcatcatcgcg
Acattcagtaattctgcaaatgccgcagatagcggtactttgaattatgaggtttacaaa
Tacaataccaatgacacgtcaattgctaatgactattttaataaaccggcaaagtacatt
Aagaaaaatggtaaattgtatgttcaaataactgtcaaccacagtcattggattactgga
Atgagtatcgaaggacataaagaaaatattattagtaaaaacactgccaaagatgaacgc
Acttctgaatttgaagtaagtaagttgaacggtaaaatagatggaaaaattgacgtttat
Atcgatgaaaaagtaaatggaaagccattcaaatatgaccatcattacaacattacatat
Aaatttaatggaccaactgatgtagcaggtgctaatgcaccaggtaaagatgataaaaat
Tctgcttcaggtagtgacaaaggatctgatggaacgactactggtcaaagtgaatctaat
Agttcgaataaagacaaagtagaaaatccacaaacaaatgctggtacacctgcatatata
Tatacaataccagttgcatccttagcattattaatcgcaatcacattgtttgttagaaaa
aaatctaaaggcaatgtggaa
236.
atgacaaaacattatttaaacagtaagtatcaatcagaacaacgttcatcagctatgaaa
aagattacaatgggtacagcatctatcattttaggttcccttgtatacataggcgcagac
agccaacaagtcaatgcggcaacagaagctacgaacgcacctaataatcaaagcacacaa
gtttctcaagcaacatcacaaccaattaatttccaagtgcaaaaagatggctcttcagag
aagtcacacatggatgactatatgcaacaccctggtaaagtaattaaacaaaataataaa
tattatttccaaaccgtgttaaacaatgcatcattctggaaagaatacaaattttacaat
gcaaacaatcaagaattagcaacaactgttgttaacgataataaaaaagcggatactaga
acaatcaatgttgcagttgaacctggatataagagcttaactactaaagtacatattgtc
gtgccacaaattaattacaatcatagatatactacgcatttggaatttgaaaaagcaatt
cctacattagctgacgcagcaaaaccaaacaatgttaaaccggttcaaccaaaaccagct
caacctaaaacacctactgagcaaactaaaccagttcaacctaaagttgaaaaagttaaa
cctactgtaactacaacaagcaaagttgaagacaatcactctactaaagttgtaagtact
gacacaacaaaagatcaaactaaaacacaaactgctcatacagttaaaacagcacaaact
gctcaagaacaaaataaagttcaaacacctgttaaagatgttgcaacagcgaaatctgaa
agcaacaatcaagctgtaagtgataataaatcacaacaaactaacaaagttacaaaacat
aacgaaacgcctaaacaagcatctaaagctaaagaattaccaaaaactggtttaacttca
gttgataactttattagcacagttgccttcgcaacacttgcccttttaggttcattatct
ttattacttttcaaaagaaaagaatctaaa
237.
Lknilkvfnttilaliiiiatfsnsanaadsgtlnyevykyntndtsiandyfnkpakyi
Kkngklyvqitvnhshwitgmsieghkeniiskntakdertsefevsklngkidgkidvy
Idekvngkpfkydhhynitykfngptdvaganapgkddknsasgsdkgsdgtttgqsesn
ssnkdkvenpqtnagtpayiytipvaslalliaitlfvrkkskgnve
238.
mtkhylnskyqseqrssamkkitmgtasiilgslvyigadsqqvnaateatnapnnqstq
vsqatsqpinfqvqkdgssekshmddymqhpgkvikqnnkyyfqtvlnnasfwkeykfyn
annqelattvvndnkkadtrtinvavepgykslttkvhivvpqinynhrytthlefekai
ptladaakpnnvkpvqpkpaqpktpteqtkpvqpkvekvkptvtttskvednhstkvvst
dttkdqtktqtahtvktaqtaqeqnkvqtpvkdvataksesnnqavsdnksqqtnkvtkh
netpkqaskakelpktgltsvdnfistvafatlallgslslllfkrkesk
239.
atgacaaagaaagaaaaggattataaaaaaagtcttgagcaacaaaaaacacgggtaaaa
atatacaagtcaggaaaaagctgggtaaaagcaagtattaatgaaatagaattgttaaaa
acaatggggctaccatttttaagtaaaaacgaaatacaagaaaatgtgactgaaaagacg
aaaggtcataaattaaaaaaaagtgcagctaaaacaacagccctagttggtggagcattt
acatttaatatgttgaataatcatcaagcatttgctgcctcagaaacaccaatcacctct
gaaatttcatccaatagtgagacagtagccaatcaaaattcaactacgattaagaactca
caaaaagaaacagtcaattctacaagtttggaatctaaccattctaatagtacaaataag
caaatgtcttcagaagttacaaatacagctcaatccagtgaaaaagctggaattagtcaa
caaagtagtgaaacatcaaatcaatcatctaagttaaatacatatgcctccacagaccat
gtagagagtacaactattaacaatgataatactgcacaacaagatcaaaataagtcttcg
aatgtaacctctaagtcaacacaatcaaacacgtcatcctcagaaaagaacattagctcc
aatttaacccagtcaatcgaaacaaaagcaaccgattcattagcgactagtgaagcacgt
actagtacaaatcaaatatctaatctgacatcaacatctacttcgaatcaatcgagtcct
acttcctttgcaaatttaagaacatttagtagatttactgttttgaatacgatggcagca
ccgacaacaacatcaacgacaacaacttcaagtctgacatctaattctgttgtggtgaac
aaagataactttaatgaacatatgaatctatctggatctgcgacgtatgatcctaaaaca
ggtattgctaccttaacgccagacgcatatagtcaaaagggtgccatatctttaaacact
cgattagattcaaaccgtagcttccgttttataggtaaagttaaccttggtaatagatat
gaaggttattctcctgatggtgtagcaggtggagatggcattggctttgcattttcacca
ggccctttaggacagataggtaaagaaggggctgccgttggaataggcggtttgaataat
gcctttggttttaaattggatacgtatcataacacatcaactcctagatctgatgctaaa
gcaaaagcagatccacgtaatgttggtggtggtggtgcttttggtgccttcgtaagtaca
gatagaaatggtatggctaccactgaggaatcaactgcggctaaattaaatgtacaacct
actgacaattcattccaagattttgtcattgactataatggtgatacaaaagtgatgaca
gtgacgtacgctggacaaacctttacgagaaatcttacagattggataaaaaacagtggg
ggtacgacgttttctctatctatgactgcctcaactggtggcgcaaaaaatttacaacaa
gttcaatttggaacattcgagtatacagaatcagctgttgctaaagtacgctatgtagat
gcaaatactggtaaggatattatcccgcctaaaaccattgcaggtgaagttgacgggact
gtaaatatagataaacaattgaacaattttaaaaatttaggttacagttatgtggggaca
gatgccttaaaagcaccaaattatacagaaacgtcaggtacacctacacttaaattaact
aactcaagccaaacggtgatttataaattcaaagatgttcaaggtcctcaaattagtgtt
gatagtcaaactagagaagttggaaagaccattaatccaattacaattactacaactgac
aatagtaaagacgtattaactacaactgtgacaggtctaccttcagggttatcttttgat
caaacgactaatacaattattggcacgccaagtgaagtaggaactacaactgtgacagtt
aatactactgatgctactgggaacgtaacatctaagcaatttacaataacgattcaagat
acaatcagccctgttgtaaatgtgacgccaagtcaagcatcagaggttttcacgccgatt
aatccaattacgataactgctacagataatagtggcaaagtggtaacgcatacagtaact
ggattgccacaaggacttaaatttgatgcatctacgaattcaattgttggaactccaact
caaataggaacaaatacaatcacgattgagtcaacggatgcgagtggaaataaaactacg
actaaaattaattatgaagtaacgagaaatagcgcaagtgactctacttccactagcata
gtaaatagtgtttcaacaagtataagtaatagtacatcgctaagtgatagtgtaaaagcg
agtcaatcattatcaacaaaagaatcaacaagtaagagtctctcaggttcgttaagtgcg
tcaacgtcgaatagtgcatcaataaaagcgagtgaatcagcaagcacaagtaagaagtta
tcagaatcagcgagtacgtcgatgtctgatagcgcatcaataaaagcgagcgaatcagca
agtacaagtaagaagttatcagaatcagcgagtacgtcaacgtctgatagcgcatcaata
aaagcaagcgaatcagcaagtacaagtaagaagttatcagaatcagcgagtacgtcgatg
tctgatagcgtatcaataaaagcgagcgaatcagcgagtacaagtaagaagttatcagaa
tcagcgagtacgtcgacgtctgatagcgcatcaacccaagcaagcgaatcagcaagtaca
agtaaaaagttatcagaatcaacgagtacgtcgacttcagatagtgcatcaacatcaacg
agtgagagtgactcaacaagtgaaagtacatcgttaagtgactcgacaagtgcgagtctt
tcagaatcgacaagtacatcaacatccgacagtgcgtccacatcaacgagtgagagtgac
tcaaacagtacaagtacgtcattgagtgagtcgacaagcacaagtctttcagaatcaacg
agtacgtcaacatcagatagtgcgtcaacgtcagcaagtgtgagtgactccaatagcgca
agtacgtcattaagagaatcgacaagtacgagtctttcagactcaacaagtacatcgaca
tctgacagtgcgtcaacatcaacgagcgagagcgactccgatagcgcaagtacatcgttg
agtggctcatcaagtacaagcgtttcagattcaacaagcgcgtcaacatcagaaagtgca
tcaacgtcaacgagcataagtgactcaaacagtacaagtacgtcattaagtgaatcgaca
agtacgagtctttcagaatcaacgagtacgtctacatccgacagtgcatccacatcaatg
agtgtaagcgactcaaatagtgccagcatatctttaagtgagtcgacaagcacaagcgtt
tcagattcaacaagtacatcgacatcagaaagtgcatcaacgtcaacgagcgagagtgac
tccaatagcgcaagtacgtcattaagtgagtcgacaagcacaagcgtttcagattcaaca
agcacatcgacatcagacagtgcgtcaacatcaacgagcgtaagtgattccaatagcgca
agtacgtcattgagtgagtcgacaagcacaagcatctcagattcaacaagcacgtcgaca
tcagacagtgcgtcaacatcaacaagtgtgagtgagtcaagcagtacaagtaagaagtta
tcagaatcagcgagtacgtcgatgtctgatagcgcatctgcatcaacgagtgaatcaaac
agtacaagtacgtcattaagtggctcgacaagtacgagtctttcaggatcaacgagtaca
tcgacttcagaaagtgcgtcaacatcaacgagcgtaagtgactccaatagcgcaagtacg
tcattaagtgaatcgacaagtacgagtctttcagactcaacgagtacatcgacatcagat
agtacgtctgcatcaacaagtgagagtgactcaaacagtacaagcacatccatgagtgaa
tcattaagcacaagcgtttcagattcaacaagtacgtcaacgtcagacagtgcatcaacg
tcaacaagtgtgagtgactccaatagcgcaagtacgtcattaagtgattcaacaagtaca
agcatttcagactcaacgagtgcgtcgacatcagatagtgcgtcagagtcagcaagcgag
agtgaatcaacaagtgaaagtacatcggtaagtgaatcatcaagtacaagcgtttcagat
tcaacaagtacatcgacatcagaaagtgcatcaacgtcaacaagcgagagtgaatcaaca
agtgaaagtacatcggtaagtgaatcatcaagtacaagcgtttcagattcaacaagtaca
tcgacatcagaaagtgcatcaacgtcaacaagcgagagtgaatcaacaagtgaaagtacg
tcattaagtggatcatcaagtacaagcgtttcagattcaacaagtacgtcaacgtcagaa
agtgcatcaacgtcaacgagtgtgagcgactcaaatagtacaagtacgtcattaagtgaa
tcgacaagtacgagtctttcaaactcaacaagtacgtcaacatcagacagtgcatcaacg
tcaacgagtgtgagcgactccaatagcgcaagtacatcgttgagtggctcattaagcaca
aacgtttcagattcaacaagcacatcgacatcagacagtgcttcaacgtcaacaagcgag
agtgactcgaacagtgcaagcacatcgctaagtggatcattaagtacaagcatttcagac
tcaacgagtacgtcgacatcagacagtgcgtccacatccacatcagaaagtgcatccaca
tcaacgagtgtgagtgagtcagacagtgaaagtacatccatgagtgtgagtgactcgaat
agtacaagtacatcattgagtgactcgacaagtacgagcgtttcagactcaacaagaaca
tcaacatccgatagtgcatctacatcaaagagtgtaagtgagtcaaacagcgccagtaca
tcggtaagtggctcaacaagtacaagcatttcagattcatcaagcacgtccacatcaatg
agtacatctgaaactttcacttctcaatctcctataaatagtgaaagtcaatttattggt
gatagcttgtctgaagatacaatcgtgactcaatcaaaaaatacgaatatgcttaataaa
actggaaaagattatgatttacaagaacaaagaggttatactgattcagaacaacacaat
gaaacacaaagtaatcaagctgataatcactcaaacaacctcgatttacttcatcaaaat
cgtttacaagataaagtcgttaaacaaccgactaaaggagaagatggagttgtaagcaac
ggttttatagtagcagtagcaatagtattggctatcttcggtttggcaaaaaaatctaga
aaagacgatgatgatcaagatggtagtaaa
240.
atgaaaaaaacagttatcgcttctacattagcagtatctttaggaattgcaggttacggt
ttatcaggacatgaagcacacgcttcagaaactacaaacgttgataaagcacacttagta
gatttagcacaacataatcctgaagaattaaatgctaaaccagttcaagctggtgcttac
gatattcatttcgtagacaatggataccaatacaacttcacttcaaatggttctgaatgg
tcatggagctacgctgtagctggttcagatgctgattacacagaatcatcatcaaaccaa
gaagtaagtgcaaatacacaatctagtaacacaaatgtacaagctgtttcagctccaact
tcttcagaaagtcgtagctacagcacatcaactacttcatactcagcaccaagccataac
tacagctctcacagtagttcagtaagattatcaaatggtaatactgctggttctgtaggt
tcatatgctgctgctcaaatggctgcacgtactggtgtatctgcttcaacatgggaacac
atcattgctagagaatcaaatggtcaattacatgcacgtaatgcttcaggtgctgctgga
ttattccaaactatgccaggttggggttcaactggttcagtaaatgatcaaatcaatgcc
gcttataaagcatataaagcacaaggtttatctgcttggggtatgt
241.
atgaataaaaataaagtgattgtaattggatcaacaaatgtagataaatttcttaatgtt
aaaaggtttccaaaacccggtgagacattacatattaatcaagctcaaaaggagtttggt
gggggcaagggagccaatcaagccatagcagctagtagattagcagcagatacaacattt
atcagtaaagttggtaaagatggcaatgccaactttatattggaagatttcaaaaaagca
ggtattcatacacaatatattttaacttcagaaagtgaagaaactgggcaagcatttatc
actgttgatgaagcaggacaaaatacgattcttgtttacggtggtgcgaatatgacatta
agtgcaactgatgttgagatgagtgtggatgcgtttattggtgcagactttgttgtagcg
cagcttgaagttccatttgaggcgatagaacaagcatttaaaattgctcgtaaacaaaat
atcactactgtattaaatcctgcaccggcaattgaattgcctaagtcacttttagagtta
actgatataattattccaaacgaaacggaagcagaattattaacaggtatttcaatcaat
aatgaaagtgatatgaaagaaacagcaacatattttctcgatttaggtatatctgcagta
ttaattactttaggggagcaaggcacgtattgtgcatatcaagaacaatacaaaatgatt
cctgcgtgtaatgtaaaagcaatagatacgacagcagcaggagatacatttataggtgct
tttttaagtgagttaaataaagatttgagcaatttagaatcggctattcgacttgcaaat
caagcgtcgtctctaacggtacaacgaaaaggagcacaagcttctataccaacacgtaaa
gaagtagaggcagaatataat
242.
atggctcttaaaaaatataagccaattacaaatggtcgtcgtaatatgactactttagat
ttcgctgaaatcacaaaaacaacacctgaaaagtcattattacaaccgctaccgaaaaga
gcgggacgcaataaccaaggtaaattgactgttcgccatcatggtggtggacacaaacgt
caataccgtgttatcgattttaaacgtaacaaagatggaatcattgctaaagttgattca
attcaatatgatccaaaccgttcagcaaacattgcattgctagtttatgctgatggtgaa
aaaagatatatcatcgcacctaaaggattacaagtaggtcaaactgtcgaaagtggtgct
gaggcagatatcaaagttggtaatgctttaccattacaaaatattccagttgggacagta
attcataacatcgagttaaaacctggtaaaggtggacaacttgctcgttctgctggtgct
agctctcaagtattaggtaaagaaggtaaatatgtattaatcagattaagatctggtgaa
gtacgtatgattttatctacatgtcgtgcaacaattggtcaagttggcaacttacaacat
gaattagtaaatgttggtaaagcaggacgctctagatggaaaggcgttcgcccaactgta
cgtggttctgtaatgaaccctaatgatcacccacacggtggtggtgaaggtcgtgctcca
atcggtagaccatctccaatgtcaccatggggtaaacctacgcttggtaagaaaactcgt
cgtggtaaaaaatcttctgacaaacttatcgttcgtggacgtaagaaaaaa
243.
atgaagtcaaaattcacaattctattatttacaatcttttctacaacagtattagttttg
gttattatttataacaaaactcaatcccaatcatacatttcgactcactattctaataat
aaaataaaaacaacagcaacactttttttacatggttatggtggtagcgaacgctcagaa
acgtttatggtcaaacaagcgttaaataaaaatgtaaccaatgaggtgataaccgctaga
gtgagtagtgaaggaaaagtatattttgataaaaaattaagtgaagatgcagcaaaccct
attgtcaaagtagaatttaaagataataaaaatggaaattttaaagaaaatgcttattgg
attaaagaagttctatcacaactaaaaagtcaatttggaattcaacaatttaattttgta
ggacattcaatggggaacatgtcatttgctttttacatgaaaaattatggggacgatcga
catttgccacaacttaaaaaggaagttaatatagcgggagtttataacgggattttgaat
atgaatgagaacgtgaatgaaattatcgttgataaacaggggaaaccaagtagaatgaat
gccgcatatcggcaattgttatcactgcataagatttattgtggtaaggaaatagaagtt
ttaaatatctacggagatttagaagatggctcacattcagatggacgtgtgtcaaatagc
tcttctcaatcgcttcaatatttactaagaggtagcactaagtcttatcaagaaatgaaa
tttaaaggtgcaaaggcacaacatagtcaattacatgagaataaagatgttgcaaatgaa
atcatacaattcttatgggaaact
244.
atgaagattggaattgatgccggagggactttaattaaaattgtacaagagcatgacaat
cgtagatattacagaactgaattaacaactaatatccaaaaagtcatagattggcttaac
aatgaagaaatcgaaacattaaagcttacaggtggaaatgctggagtaatagcagatcaa
attcatcattcccctgaaatatttgtagagttcgatgcatcatcaaaaggtttagaaatt
ttattggatgaacaaggtcatcaaattgaacattacatttttgctaatgtaggtacaggt
acttctttccactattttgatggaaaagaccagcaacgtgttggaggtgtaggtaccgga
ggcgggatgatacaaggtttaggctatttattgtccaatataacagattataaagaatta
acgaatttagctcaaaatggagatcgtgatgccattgatttaaaagtaaaacatatttat
aaagatactgaaccaccaattcctggagatttaacagcagcaaattttggaaatgtatta
catcacttagataatcagtttacatcagctaacaaacttgcctctgcaattggcgtcgtt
ggtgaagttataacaactatggctattacattagcacgtgaatataagactaagcacgtt
gtatatatcggttcatcatttaataacaatcaattactacgtgaagttgttgaaaattac
actgttctaagaggatttaaaccgtactatattgagaatggtgctttttcaggcgcttta
ggagcactttacctc
245.
atgactttaaataaccattttgcatatacatttgaggagagacctaccccaaaattatgg
ctttgtaaaccagatggaactagaattgaaagaattgcagatttttcaaaacttggtgga
acattcaaattcactaatgtgaacactttacattttgatttgccattgcaagtatttagt
gaagatactaagcaaattgaaagaaataaagtagttgatttagtaaaaaataaatactta
attgattatagatataacggatatagagatatctttgtaattgatgatattaaaaaatct
gctaatgactctgattttattacattaaatttagactcaagagcgtctgaattaaataag
aaagctgcaaatgaaattgaattattaggttctactatccctcaaatgatgaacaaaatc
ttatcagtttatgctccactatggaaacttggacatgttgatggaaaaattattgatgtt
aaacgtgagttaactggttctaatacaactgttaacgctcttattgataatatttgttct
ctttttgacgcagttgctatttataacaacattaatagaacaataagcttctatcataaa
gacaatgttggtactaatcgtggtttaagagttagggaaaatagttatttaaaatcattt
gaagatcaatttgtatcaaaggatatcgttactagattatatccatttggtcaaagtggt
ttaacaattcaaagtgttaacccagctggctcttcttatattgaagacttctcttatttc
atgtcaccattcaaacgtgataataacagaaatgtattacaacatagtgattatatgtct
gatgaattatgtcacgctttgttagattatcaagagttttatgctagtaagaaggatcaa
gctggtgaattatctaaacaatatagtgcaattcttaaagagcattcacaagaagacttc
agattaaatcaattaagtgctacacttcaacgactaaatgagcgtgttgaattagttaaa
cctaaatcagaatatattgacttaggaacaaaggttaagaatttcaaaatcactgtacct
aaatcatcatattatttaatcatgattagaaatgatggtagtttcactagaattaaattc
aataataaacagtatgatattccaagtggtgagtggttgtatatcaaacttaaaactggt
aagtttaatgacgctactaagtttgagaaacaattagaataccctcttgaaatattaagt
gcaaacgctaatttaagagtggtatatactcgttcttctgaaggagattatgaagaagaa
gatactaagacaatcgaagaaaaatacaacttagaaaaatataaaattttagtaaaagat
caagaaaaagtagtcgcttcaatcgaaagacgattaaaagcttttgaagaccaaaaagca
agtgtaatacgttcaatgaatgcaaagaatttcttatctgaaaaactttataatgaacgt
gagttatatgtttttgagtctgtttggacggaagaaaatcatacagacgctcaagaatta
tatgatgacgctgtaaaacaaatgaaggaacaaaagaaaatcaatagaacgattacagtt
gatttagttaacttcattcaatcgcttgaccataaagatgattgggataaattaaatgtt
ggagataaagttgttttccaaaacaaaatcttcaatactaaaatcaaagcctatatcact
gaaatgcaattagatttccaaactaatcaagtaaaaattactattagtgatatttttgat
tacaaagatttagacacaatcatcgctgaaaaattagcccaaactacctctacttcttct
caagttgatttccataaacaacaaattagagagcaaaccggaagaattacagatatgact
cgtcttatcgaaggtgagtgggacgcaaataaaaagcgtgtgatggctggtaatgaaaca
gttgatattggttcacatggtgttaaagtcatttcaaaagagaaccctaacgaattcgta
atcatggttggtggcgtaattgctatgactcgtgataacggtgaaacatttaaaactggt
attacaccagaaggtatcaatgctgaaatgcttatcggtaagatgatcgttggtgaaact
ttaacttttgaaaatgagtctggtacagttaaattcgacaaagatggactttatgttaac
tctaaaaacttccatttagtttcaaatgatggagaagaagactacttcgataaattaaaa
cgtgaaatgtctgaaaacgctaaacaacaaacagacagaatgttagaagagtataaaaaa
gaagtttcacaaactatttctgaagctactgacgttagaaacattgttgataatgcagca
gatattcttcaagcagcttttgctgatggagttatcacagatgttgaaaaacgtttgatt
tctgaaactcttgctcaacttgaaaaagaaaatagagaattcgaagataaaattaactta
gctttaaaccacccttacatcactgaggaagatactattgagttaaataattctatcgtt
gaatatagctcaatgtatgaaacacttgttatttctattaatgaaagtgttagtgacaag
atgatcacacctcaagagtctgaagaaattaatcaaaatattataaacttcagagaagag
atcaaagacatcttatcattagtagaagaaattattgaacgaactaaaaatgctcaacta
caagctactttagaagaagcaaaagattatacaacaagagttcgtgacgatattaaagat
gaattaaaagacttaaataattcatttaaatctttaaatagtacagttgaagagtcatta
caagataatatttttgacgctgctgaattagaagctattaaaacagttgtattagtaact
aaatcagaatatcaagatattacaaatagatattcttcaatgtctgcaaatacagattta
aaatcggaaagtaaattagatttaacaaaatcttataaaactttagatactagctttaat
gactttgttaaatatattgacgaaatgacaatggatagaattgcagatgagactgagaaa
gttaattacaaaaagaaatatgatactttacaaaagaacttatcagattatatgaaaaaa
tatgataactgtattttggaaatatctaaaaagtattctaatgacgcagcagataaagtg
ttaggtgacttcacagctattgctactgaattacaaaatgatttccaagatgttaaagac
aattgggctgaattcaagcaaactactcttgagtcatttaaagatggtatagtaactgag
gcagaaaaagctcgactaagagtacaattagatatgcttgatcgtgaaagcatggatatt
gaagaacgatataaaagcttacttgctaaccaatatactaatactgatattaaaaatcgc
ttaactgcttcacgttctccttacttatcagttcatgctagtttaagaaaagtaattgaa
caaataattgctgacggaaaagttgatgaaagtgaaaaaacattagctaataattcactt
aatacatacaacacaacattaactgcttattctaaaacaattcaagaagctctaaataca
ttatcacaaatcatctcttctgatgtagcaagtaaaaaagttgaagaattcaatggtgta
ataactacaatttcttcagacgttgatacaatcaagaaacaaagagatggtgcagtaatc
acttattattatagcggtgtacctacattatctaacgatccagctaaaagttggacgact
aatgatttaaaagacttacatattaaagatatgtatttagacactaaatctggttatgca
tatactttcactaaatctggtactagttattcttggaaaccacttactgaccaagttatt
gttagctcattgaaacaagcaaaaaatgcacaagacacagcggacaataaacgtagagtt
tttgtaactcaacctattcctccttatgatcaaggagatatgtggactcaaggttcacaa
ggagatatttatgtctgtggaacttcgagagctactggctcattcgtaagtagcgactgg
gttaaagcgagcaaatacactgacgatacagtagctaaacaggcagcaaaagatttagaa
gattataaagtcaaaatgactaaagacttcaaagatttaaatgacggtgtatctactttt
aaaactgaagtggttaaagatttcaaagatggaattgtaactgaagctgagaaaactaga
ttacgtgttcaattagatatcttagatagagaaagtcaagatatcgaagaaagatataat
agtatctttaacagtcaatatgcagatactcaagttaaaacttctatttctaacgcacgc
tctacttataataactctcttactaagttaagaaacactattcaaaccgtgattgaagat
ggaaaagtaacgcctactgagaaaactactgctaatcaaactttaaccgcatataataat
gctttaacgagttattcagctgctatccaagaagcattaaatagcatgtcaaaagtaatt
gctcaaaaagaagctactagtcaagtaaatcaattcaatgaagttatcaaaaatataaat
acaaatattactgatattcaaaaacaagttgatggtgcaattgaaactttctattacagt
ggagtaccaacacttactaatatccccgcttcgtattggacaactgctagtaaacgtgaa
gctcatttaggtgatttatatttagacactgctactggtgttgcttatcgtttcttaaaa
aaaggaacaacttcccctacttactattggtctccaatttctgatcaaattattacagac
gcattgaatagagcaaaaacagctcaagacaccgccgatggaaaaagaagagtttttgta
aatacacctgttccaccatacgacactggtgacatgtggacgcaaggagctagtggtgac
atcttagtttgtaaaacacctaaagctaaaggtggtatttactcaataagcgactgggta
aaagctagtaagtatacagatgatacagtagcaaacagtgctgttcaacaattaaatgaa
tacaaacgcactaataatcttgatatcgcagacctaaagagaaaaactagtgacttcgaa
aaaacagttgtaaatgcatttgacgatagagtcattagtatttccgagtcttcatctatt
aaaggacaacttgctctacttaatcacgaaaaagatagattaactagacaatacgaaaat
ataatcagaaattctaatcttgttggagcagaaaaaactaaattatctactgcatattca
aatataaatactaagcttagtgatttaagtacaactattaatagtgcaattgttgataat
aaaattgttgacgctgaaagtaaatctgtaacttcaaaatttgaattgtataaagcttca
gttaatgaatatcaaatcgcttttgataatgctctaaactcaattattagagaaatcgct
tcttcccaagctaaagatagattagatgaatggaaacgtacagaatttagtacagactca
gacggtattattgaaagagtagctggtgctaagtttgactcaaaatggactgatacttgg
agaaatacagttaacccagctattcaacaagtgagtaatataacatatggaagtgaaaac
ctattacttaatagcgaaagtcgaagtgacggtgctaataccacgactcactcttttata
agatactacctgacacgccctttagaaacagggaaaacttatactttaaaagctagtgtt
ttaacaactgatgaaagacaaagtggacaaattagtgtttatccatactcccctaacgga
gcaagagagacagtaaatattaaagacggtaaaattacttatacatttactgcacaaact
gaaagtacacaatttcttatttataaagacgtggctggtcaatctgatgtagacttaaat
gtaacaatcgagaaggctattttagtcgaaggaaataaagttacagggtggtctccagca
ccagaggagacttcttctgctttacgagattataatactcgtatctcctcagcagaaaca
ttcattgagaaaaacaaagaaaagatttctcaaattgctactaaatctgatgttgacgct
tcacttagtaaagtagctacttatgaaactcaatataatgtttctagcggaactaactat
caaattcctcttcaagaatacaatggttcattctttaccgacaactacacttatgaagtt
gtagctaaaaataactctttaagttctaacaacgtagcaactgctatattcgtaagtaaa
ggttcaaacaatggttatgaattggttgaattagacaacatgtctaaaactggtgctaac
cctagatttgttttagacagtaaaggtagaccttctatctctactttctcccctcaatct
actactcaagatatttcagttatttacactaaatatttaggtagtgcttcagcaatcaat
acaactaaatcattgattgagcaaactgctagttctattgaattacaagttaagaaactt
actgctgagactgaatacaacaacatattattaaattcagacttctcttctggctgggaa
ggttggataaatgttgatcctcagtatagtattgttgataaaaatacttttggtatcact
cttcctgacgcaatcactaataaaaataagaaatataatacagttaaaatgacatacaat
aaaaatacaaattacccttctgtattttctaattttatttctgttggaaaaggtcaagag
gtagctattggtgaacatttaacactaacttgttatgcctatatcccttcttcatctaaa
ggtaaattaactggtaacatatatattgaattcgctggttactatgaaaaagaccaaaaa
tcaaacccaatgattgctagacatgaaatattacctaaagattttgaatataataaatgg
ttcagaatgacagctagtactgctattccttctactaactctgagggtaaaaaaatcaat
tatattagagcttgtttacgttatgacggtaaaaatcaaagcgtaaataatagtgctata
ttctattatgcgttacctcaattagagcgtggatcaaaaccaaccgagtggtcgttatca
agacttgacgtatttagcactgaacaattggcagctaagattgccttaaacccagagagt
gtggatattatcgcaagaaatattgatttcaatactgactcaatgaagatttataattct
aacggtacattaaacatttctggagatactttaacaattagtaacaacaatagttctaat
gaagtaattataaatccaaaaggttttacacttaaaaaagatggtgtagttaagtttaaa
aatggactagacacaagcgattatagtgtccaagcttatgaaccacagtttagttcatgg
aataatattaaagctactgatcccgctgctaagagtaagtataattacattcgacatatt
gagccggggatgaatggttattacactataaatactggtgtttacaattttgcagtacaa
cacaaacaactattagaggtaaataatacaaaaaatgcgagagttaacaggtatacatat
ctttacaacaaaaggtatttaaaaatacaaatgtctgcttcttctcgaggtaaaagtaag
ctttatataatattcaagacaaaaactggagatactacactccatcaagaaatagttagt
tctagttcaatggtatacccagatataacaattgacttacaggctaaattaggttatccg
cctaacaatttgccagacttttttgaattacaagctggtattgcctatggagaaaataat
tctattgatggtttctttagaattagacgtatggcaatgacagatacaccaaatgcggag
gtt
246.
atgtataacgtgacacagcatgcgacttataaaacaaaaaataaacgagaaactgctgta
ttaatcggtgtacatgctcaaacggatcgtcaatttaattttgaatctactatggaagag
ctcgatgctttatcacaaacttgccaacttaatgttaaaggacaaatcactcaaaataga
gagcaatttgaccataaatattatgttggaaaaggaaaaatcgatgaaataaaatctttc
atagaattccatgatatagatgttgtcgtaaccaacgatgaattaacgacggcacagtct
aaaacgttaaatgataatttgggcattaaaatcatcgatagaacccaattaattttagag
atattcgcgttgcgagcgagaagtagagagggaaagctacaagtagaacttgcacaactc
gattatttgttaccaagactacatggtcatggtaaaagcctgtctcgtcttggtggtggc
ataggaacaagaggcccaggtgaaacaaaattagaaatggatcgtcgccatattagaaca
cgtatgaatgagattaaacatcaattaaaaacggtcgtggatcatcgggaaagatataga
aataaacgtgaacaaaatcaagtttttcaaatcgctttagttggttatacaaatgcagga
aaatcgtcatggtttaatgttttagctaatgaggagacctatgaaaaaaatattttgttt
gcaacattagatcccaaaacacgacaaatacaagtgaatgaaggatttaatttaattatt
tctgatacggtaggatttattcagaaattaccaacgacattggtggctgcgtttaaatct
acactagaagaagctaaaggtgcagacgtacttatgcatgtcgtcgatgcaagtcattcg
gaataccgtactcaaattgacactgtaaatcaaattattaatgatttagatatggaccat
attccacaagtagttatttttaataaaaaagacttatgtaacgaacagatggatgtacct
gtatctaaatctgcgcatgtttttgtatctagtcgtgatgaaaatgataaacaaaaggtg
aaaaatttagtaattcaagaaataaaaaatagtctcagcccatacgaagaaattgtagat
agtgctgatgcagatagattatattttcttaaacaacacacgcttgttactgaattaata
tttgacgaaacacaagcatcttatcgtatcaaaggatttaaaaaatta
247.
atgatgatcatcgtcatgttaatcttgagttatctgattggtgcattcccaagcgggtta
attattggtaaattattttttaaaaaagatataagacaatacggtagtggaaatactgga
gcaactaacagttttcgtgttcttggaagaccagctggatttatagttacgtttttagat
attttcaagggatttattacagtcttttttccactatggttcccagttcatgcggatggt
gttataagcaccttctttacaaatggtttaatagtaggattgtttgcaatactcggtcac
gtgtatccaatatatctgaaatttaatggcggaaaagcagtagctaccagtgcaggagtt
gtattaggtgtcaatcctattttacttcttatcttggcaattatcttttttagtgtatta
aaaatctttaaatatgtttctttatcaagtatcattgcagcaattagttgtgtgattggt
tcaatcatcattcatgattatattttacttgctgttagcggaattgtttcaatcatatta
ataattcgacacaaatctaatatagttagaatttttaaaggagaagaacctaaaattaaa
tggatg
248.
atgatgaatcatagtgaagctttaactgaacaagtattttcatttgcttcagagctttat
gcttatggtgtaagagaagtagtaattagtccaggttcacgttcaacaccattagcactt
gttttcgaagcacatccaaatattaaaacatggattcaccctgatgagcgaagtgctgca
ttttttgctttaggtcttattaaaggtagcgaaaaacctgtagcaattctttgtacatct
ggaacagccgctgcgaactacacacccgctatagctgaaagtcaaattagtcgtttgcct
ctcgttgttttaacgagcgacagaccgcatgaactgcgcagtgtgggtgcacctcaagca
atcaatcaggtaaatatgtttagtaattatgtgaactttcaatttgatttgccgattgct
gatggaagtgaacatacaattgatacaattaattatcaaatgcaaattgcaagtcaatat
ttatatggaccacaccgaggaccgattcattttaatttaccatttagagaaccactaaca
ccagatttagatcgtgtcgatttattaacatctgtaactaaaacgttacctcattatcag
aaatcgatttcggtagatgatataaaagacatattacaagaaaaaaatggtctcatcatt
gtcggagatatgcaacaccaagctgttgatcaaatattaacgtattcaactatatatgat
ctgccaatcttagcagatccccttagtcagcttcgtaaagagaaacatcctaatgttata
accacttatgatttattgtatcgagcaggattaaatttagaagtagactatgtcatacgt
gtaggtaagccagttatttctaaaaaattaaatcaatggttgaagaaaaccgatgcgtat
caaattattgtgcagaataatgatcaaattgatgtatttccgacaccacctcatatatct
tatgagatttcagcaaatgattttttccgttcattaatggaagaaccacttgttgaacga
aaaaaatggttacagcaatggcaatcacttgaacaacaagcacgcattgaaataagtgat
tacttaaagcatgcgacagatgaagcggcatatgtagggagtttaattcaaaaacttaca
aaagaagatacattatttgttggaaatagtatgccaattagagatgtcgataatttactg
tttgatagtgaggcatctgtatacgctaatcggggtgccaatggaatagacggagtagtt
tcaactgcgctaggtatggcggcacataagaatgtgacattgcttattggtgatttatct
ttttatcatgacatgaacggtttattaatggccaaattaaatgaacttcatattaacatt
gtattagttaataacaacggaggaggtatcttttcatatttacctcaaaaacgatcggct
acaaaatattttgagcgattatttggaacaccaacaggcttaaactttgaatatactgca
ctgttatatgattttacatttaagcgctttgataatttgactgactttaaatatgctgaa
ttatctaaaatgggttctcacatgtatgaagttataaccaatagagacgaaaatttgcat
caacaccaaaatttatatcagaaattgagtgagattgttaatgttacatta
249.
atggcgaaaaaattcaattacaaattaccgtctatggttgctttaacgttatttggcaca
gcttttactgcacatcaagcaaatgctgctgaacaaccacagaatcagtctaatcataaa
aatgtattagatgatcaaactgccctcaaacaagcagaaaaagctaaaagcgaagttaca
caatcaactacaaatgtatctggtacacaaacatatcaagaccctacccaagttcaacct
aaacaagacacacaaagtactacatatgatgcatcattagatgaaatgagtacttataat
gaaatttcatcaaatcaaaagcaacaatctttatcaacagatgatgcgaatcaaaatcaa
acgaattctgttacaaaaaatcaacaagaagaaacaaatgatttgacacaagaagataaa
acatccactgatacaaatcaattacaggagacacaatctgtagcaaaagaaaatgagaaa
gatttaggagctaacgcaaataatgaacaacaagacaagaagatgactgcaagtcaacct
tccgaaaatcaagcaattgaaactcaaactgcttctaatgataatgaaagccaacaaaaa
agtcagcaagtaacttctgaacaaaatgaaactgctacacctaaagtatcaaatacaaac
gcatctggttataattttgattacgatgatgaagacgatgatagctcaacagaccattta
gagcctatctcattaaacaatgtgaatgctacatctaaacaaactacttcatataaatat
aaagaaccagctcaacgtgtaacaactaatactgtaaaaaaagaaacggcatctaatcaa
gcgactatagatacaaagcaattcaccccatttagtgcaactgctcaaccgagaacagtt
tattctgtatctagtcaaaaaacatcatcattaccgaaatatacaccaaaggttaattct
tcaataaataactatattcgtaaaaagaatatgaaagcaccaagaattgaagaagattat
acgtcatatttccctaaatatggctatagaaacggtgtgggacgtcctgaaggtatcgtt
gttcatgatactgcaaatgataactcaacaatcgatggcgagattgctttcatgaaacgt
aattacacaaatgcattcgtacacgcatttgttgatggcaatagaattatagaaacagct
ccgacagattacttatcttggggtgcaggtccatatggaaatcaacgttttatcaatgtt
gaaatcgtccatacacatgattatgattcatttgcacgttcaatgaacaactacgctgat
tatgctgcaacgcaattgcaatattataatttaaaacctgatagcgctgaaaacgatgga
agaggaacagtttggacacatgctgctatctctaacttcttaggaggtactgatcacgct
gaccctcaccaatatttaagaagtcacaattatagctatgcagaattatatgacttaatt
tatgaaaaatatttaattaaaacgaagcaagtagcaccttggggcacaacatctacaaaa
ccgtcacaaccttctaaaccatcaggaggaactaataataagttaactgtgtctgctaat
cgtggtgttgctcaaattaaaccaacaaataatggcttatatacaactgtttatgacagt
aaaggtcataagactgatcaagtacaaaaaactctatccgttactaaaactgcaacatta
ggaaataacaaattctatttagttgaagactacaatagcggtaaaaaatacggttgggtt
aaacaaggtgatgttgtttataacactgctaaggcaccagtaaaagtgaatcaaacatat
aatgttaaagcagggtcaacactttacacagttccttggggtacaccaaaacaagttgct
agcaaagtatctggtactggaaatcaaacatttaaagcaactaaacagcaacaaattgat
aaagcaacgtatctttatggtacagtgaatggtaaatctggttggattagtaaatattac
ttaactacagcatctaaacctagcaatccaactaaaccttcaacaaacaaccaattaaca
gtgactaacaatagtggtgttgctcaaatcaatgcaaaaaatagtggcttatatactaca
gtttatgacactaaaggaaagacaacaaatcaaatccaacgtacattgtcagtgacgaaa
gctgccacacttggtgataaaaaattctatcttgttggtgattataatactggtacaaat
tatggttgggtaaaacaagatgaggtcatttacaacacagctaaatcacctgtaaaaatc
aatcaaacatacaacgtcaaacctggtgttaaattacacacagtaccttggggcacatat
aatcaagtggctggaacagtttcaggtaaaggcgatcaaacttttaaagcaactaaacaa
caacaaattgataaagcaacatatctttatggtacagtgaacggtaaatctggttggatt
agtaaatactatttaactgcaccatcaaaagttcaagctttgtctactcaatcaacacca
gcacctaaacaagtaaaaccatctacacaaactgtaaatcaaattgctcaagtgaaagct
aataattctggaataagagcatctgtatatgataaaacagccaaaagtggtacgaaatac
gctaaccgtacattccttatcaataaacaacgtactcaaggtaataacacgtatgtacta
cttcaagatggaacaagtaatactccattaggatgggtaaacattaatgatgtgacaact
caaaatatcggaaaacaaactcagtctataggtaaatattcagtaaaacctacaaataat
ggtctatattctattgcttggggtactaaaaaccaacaattactagcacctaatacgcta
gctaatcaagcatttaatgcttccaaagctgtttacgttggtaaagatttatatctatac
ggtacagtcaataacagaacaggatggattgctgctaaggatttaatccaaaacagtact
gacgctcaatcaacaccatataactatacttttgttatcaataatagtaaaagttatttc
tatatggatccaacaaaagcaaaccgatattctttaaaaccatattatgaacaaactttc
acagtcattaagcaaaaaaatattaatggcgttaaatggtactatggtcaacttttagac
ggtaaatatgtttggataaaatcaactgacttagttaaggaaaaaattaaatatgcatat
actggaatgactttaaataacgcgataaatatccaatctcgtcttaaatataaaccacaa
gtacaaaatgagcctttgaaatggtcaaatgctaattatagtcaaattaaaaatgctatg
gatacaaagcgtttagctaatgattcatccttaaaatatcaattcttacgtttagatcaa
ccacaatacttgtcagcacaagctctcaataaattattaaaaggcaaaggtgtacttgaa
aaccaaggcgctgcatttagccaagctgcacgtaagtatggtctaaatgaaatttatctt
atctcacatgctttagtagaaacaggtaatggaacttcacaacttgctaaaggtggagat
gtttcaaaaggtaaattcacaactaaaacaggtcacaaataccataatgtctttggaatt
ggtgcatttgacaataatgcacttgtagatggtatcaaatacgctaaaaatgctggatgg
acttctgtctctaaagcaattattggtggcgctaaattcattggaaattcatacgtgaaa
gcaggacaaaatacgctatataaaatgcgttggaatcctgcaaaccctggtacgcatcaa
tatgcaactgatattaattgggcaaatgtcaacgcacaagtattaaaacaattttatgat
aaaattggtgaagtcggtaagtacttcgaaattccaacatacaaa
250.
gtggcatttgaatttagattacccgatatcggggaaggtatccacgaaggtgaaattgtt
aaatggtttattaaagccggcgatacaattgaagaagatgatgtattagcagaagttcaa
aatgataaatctgtagtagaaattccttctccagtaagtggtactgttgaagaagtgtta
gtagatgaaggaacagtggcagtagtaggagatgtcatcgttaaaattgatgcacctgat
gcagaagaaatgcaatttaaaggtcatggcgatgatgaggattctaagaaagaagaaaaa
gaacaagaatcaccagtgcaagaagaagcttcatcaactcaatcacaagaaaagacagaa
gtagatgaaagtaaaactgttaaagcgatgccgtcagtgcgtaagtatgcacgtgaaaat
ggtgtcaatattaaagctgtaaatggttctggtaaaaatggacgaatcacaaaagaagac
atcgatgcatacttaaatggtggtagttccgaagaaggttcaaacactagcgcagcatct
gaatcaacttctagtgatgtcgttaatgcttctgcaacacaagcattaccagaaggcgac
ttccctgaaactacagaaaaaatacctgcaatgcgcaaagcaattgctaaagcaatggtt
aattctaaacacactgcacctcatgttacattaatggatgaaattgatgtgcaagaatta
tgggatcaccgtaagaaatttaaagaaattgctgctgaacaaggtacaaaacttactttc
ttaccatatgttgttaaagcattagtttctgcacttaaaaaatatccagcacttaatact
tctttcaatgaagaagctggagaggttgtacacaaacattactggaatattggtattgct
gcagatacggataaaggattattagtaccagtagttaaacatgccgatcgtaaatcaata
ttcgaaatttctgatgaaattaatgaactagctgtaaaagcacgtgatggtaaattaact
tcagaagaaatgaaaggtgcaacatgcacaattagtaatatcggttccgctggtggacaa
tggttcactccagttatcaatcacccagaagtagctatcttaggaattggccgtatcgct
caaaaacctatcgttaaagatggagaaattgtagctgcaccagtgttagctttatcatta
agctttgaccatagacaaatcgatggtgctactggacaaaatgctatgaatcacattaaa
cgcttattaaataatccagaattattattaatggagggg
251.
atgaatgaaacagacgaaatttcacaaatctataacaagcatcgattaccaagtttaagt
ggtctagcaaaagtgtctccacttgttcatagggccagcataggaggcgttttaaatgtg
gcagaattaaacagaattaaacgcctagttcaagtgcaaaatcaatttaaaacattttac
aatcaaatgctagaagaagatgaagaggttaagtatcctatactgcatgataaaatgaat
catctaccgatacttacagatttatttaaagaaattaatgaaacatgtgatgcacacgat
ttatttgaccatgcaagttatactttacaaagtattagaagtaaaatttcaagaacaaac
caacgaattcgtcaaaatttagatagaatagtgaaaaatcaagggaatcaaaaaaaacta
tctgatgcaattgtaacagtaagaaatgatcgcaatgttattccggtgaaagctgaatat
agacaagatttcaatggtattgttcatgatcaatcggcatcaggacaaacactatatatt
gaaccgaattctgttgtagagatgaataatcaaatcagtcgtttgcgtaatgatgaagca
gttgaacgtgaacgtatattgactgaattgacgggatttgtttcggcggaagctgacgca
ttactcattgctgaatcggttatgggtcaaattgattttttaattgctaaagctcgttat
gcgcgcactataaaagggacaaaacctacatttaaagaggatcgaactatatatttacct
aatgcatttcaccctttattagacaaagatactgttgtagcaaatacaattgaatttatt
gacgatgtagaaacagtcataattactggaccaaacacgggtggtaagacggttacttta
aaaacactaggattgataattgtcatggcacaatcaggattgttaattcctacactggat
ggaagtcaattaagtatctttgaaaatgtatattgtgatattggagatgaacaatctata
gaacaatcattatcaacattttcatctcacatgaaaaatatagtagaaatattacaagat
gcagatcaaaatagtctcattttatttgatgaactaggcgcaggtacagatccaagtgaa
ggtgcggcactcgcaatgagtatcttagattatgtacgccgtttagggtctttagttatg
gcaacaacacattaccctgaattaaaagcttatagttataatcgtgaaggtgtcatgaat
gcaagcgttgaatttgacgttgaaacactgagcccgacttataaattattaatgggtgtt
ccagggagatctaatgcctttgatatatcgaaaaaacttggtctaagtctcaacatcatt
aataaagctaagacaatgatagggacagacgagcaagagatcaatgccatgattgaatca
ttagaacaaaattcaaaacgtgttgatcaacaacgtatagaattagatcgacttgtgagg
gaagcacagcaaacccacgatgctttgtctaaacaataccaacagtatcaaaattatgag
acatcattgatggatgaagctaaagaaaaagctaatcagcgtgtgaaatctgcgactaaa
gaagcggacgaaattcttaaagaacttagaaatctaagagatcataagggcgctgaggta
aaagaacatgaattaattgataaaaagaaacaacttgatgatcaatatgaggtaaaatca
attaagcaacatgttcaaaagaaaaagtatgatacgattcatactggagatgaagtgaaa
gttctatcttacggtcaaaaaggtgaagtgcttgaacttgtaggtgacgaagaagcagtt
gtacaaatgggaatcattaaaatgaaattacctattgaagatttagaaaaaacgaaaaag
aaaaaagaaaaacctacaaaaatggtaacaagacaaaatagacaaactattaaaacagaa
ctagatttaagaggatatcgttacgaagaagctttaaatgaattagatcaatatcttgat
caggcggttttaagcaattacgaacaagtttatattattcatggtaaaggtacgggggca
cttcaaaaaggtgttcaacaacatttgaaaaaacataaaagcgttagacaatttagggga
ggtatgcctagtgaaggtggatttggtgtcactgtggcagaactcaag
252.
atgagtttttttaaacgtctgaaagataaattttctagtaaaaatgaagatgatattcaa
aaagacctggatgaatctgtagattcaaatgttaacagtgattcagattcaatggatccg
aatgattctgatgaacaagttaaacccaaaaagaaacctaaaaaattaagtgaagctgat
tttgacgaagatggcttgatatcgattgaagattttgaagaaatagaagctcaaaaaatt
ggagcaaaattcaaggccggtttggaaaaatcacgtcaaaacttccaagaacagttaaat
aatttaattgctcgatatagaaaagttgacgaagatttcttcgaagctctggaagaaatg
cttattactgcggacgttggttttaatactgttatgaaattaactgatgagctacgtaca
gaagcacaaagacgtaatatacaagaaacagaagacttaagagaggttatagttgagaag
attgtagaaatctatcatcaagaggacgatcattctgaagcaatgaatattgaagatgga
cgtttaaatgtcatactgatggttggtgtgaatggtgtcggcaaaacaacaacaattggt
aaattagcttatcgttatcaacaagaaggtaaaaaagtaatgttagctgctggtgatact
tttagagctggagcaattcaacaattaaacgtctggggagaacgtgttggcgttgaagtt
gtgagtcaaaacgaaggttctgaccctgcagcagtagtatatgatgcgattaatgcagca
aaaaataaagacgtagatattttaatttgtgacactgcaggacgcttgcaaaataaatct
aatttaatgcaagagttagataaaatgaaacgtgtgattaatcgagcaatacctgatgcc
ccccatgaagctttattatgcttagatgcaacaactggtcaaaatgcactttcacaagca
cgttcatttaaggaagttacaaatgtctcaggtatagttttaactaaattagacggtact
gctaaagggggtattgtattagcaattcgaaatgagttacacattccagttaaatatgtt
ggtttaggtgaaaaaatggatgacttacaaccgtttagtcctgaaagctatgtatatgga
ttatttgctgatatgatagaacaaaatgaagatattcctgaagaaatctctagaaattca
tccgttgaatctgaagaaggtaac
253.
atgaaaagaaattggtggaaagaagcagttgcatatcaagtatatccacgaagttttaat
gatagtaatggagatggaataggtgatctacctggattaattgaaaaattagattatcta
gaaaatttaggaatagatgtcatttggttaagcccaatgtatccatcaccaaacgatgat
aatggatatgatattagtgactacaaaggcattatgagtgaatttggtacaatgaacgat
tttgatcaattgttatcaagcatacatcaaagagggatgaaattaatattagacttagtg
gttaatcacacatcagatgaacacccttggtttattgaatcaaaatctagtaaaacaaat
gcaaaaagagattggtatatttgggcagatcctaaaccggatggatctgaacctaataac
tgggaaagtatctttaatggttcaacttgggagtttgacgaatcgactaagcaatactat
ttccatttatttagcaaaaagcagccagatttaaattgggaaaatccagatgtaagacaa
gctgtgtttgaaatgatgaattggtggtttgaaaaaggtattgacggatttagagttgat
gccattactcatattaaaaagaattttgaagcaggagatttacctgtacctgatggcaaa
aaatttgctccagcatttgatgtagatatgaatcagccaggaatacaagaatggctccaa
gaaatgaaagataaatcgttaagtcggtatgacattatgactgtaggcgaggctaatggt
gttactcctaatgatgctgaagaatgggtaggagaagaaaatgggaaatttaatatgata
ttccagtttgaacatcttggtttatggagtactggcgatacgaaattcgatgttaaatcc
tataaacaagtcttaaatcgttggcaaaagcaactagaaaatgtaggttggaatgcttta
tttatcgaaaaccatgatcaaccacgtcgtgtttcaacctggggtgatgataaaaattat
tggtatgaatcagcaactagtcacgctactgcctactttttacaacagggcacacctttt
atttaccaaggtcaagaaataggtatgactaattatccatttgaaagcattgaaagtttc
aacgatgtcgcagtgaaaactgaatatcaaatagtcaaaaaagaaggtggagatgtcaat
caattactagataaatataaaatggaaaaccgagacaatgcaaggactccaatgcaatgg
aataattctatcaatgctggattcactactggtaagccatggtttcatgtaaaccctaac
tatacagaaattaatgttaaacaacaactaaatgataagttttcgatactttcttattat
aaagcgttaattcaactaaaaaaatctgatttgatttacacctacggtaagtttaatatg
gtcgatgctgaaaataagcaggtttttgcatatacacgcacatttaaaaacaatactgta
ttaattgtagccaatctcacaaatgaagtatcagaactaaacctaccttttgaattagat
atttcatctgtagatataaaattgcataattatcacttaaatgatataaatttagaccat
attaaaccttatgaatcattcgtcgttgaaata
254.
ttgagtcatagaaagctatttccttctatattccatttatatcaacaagacaatttagat
gaacatattgctattattggtataggacgtcgcgattataataacgaacaatttcgcgac
caagttaaagcgtcaattcaaacttatgttaaagatacagatagaattgatgagtttatg
acgcatgttttttatcataaaactgacgtgagtgataaagaaagttatcagtcattactt
caatttagtgagcgactagattcagaatttgctttaggtgggaatcgtctgttttactta
gcgatggcaccacaattttttggagtgatctcagattaccttaaatcttctggtcttact
caaactacaggatttaaacgcttagttatagagaaaccatttggcagtgatcttaaatct
gctgaatcattaaataatcaaataagacgttcgtttaaagaagaagaaatttatcggata
gatcactatcttggcaaagatatggtgcaaaatatagaagttttgcgattcgcaaacgcg
atgtttgaacctttatggaataataaatacatttcaaatattcaagttacatcatcagaa
gtattaggtgtcgaagatcgtggtggctactatgaatctagtggtgcacttaaagacatg
gtacaaaatcacatgctacagatggttgctttacttgcaatggaagcaccgataagtttg
aatagtgaagatatacgtgcagaaaaagtcaaagtacttaaatctcttagacaattaaaa
ccagaagaagttaaaaagaatttcgtgcgtggtcaatatgatcaaggcaatatagatggt
aaacaggttaagtcatatcgagaagaagatcgcgtagcaaaggattcggttacaccgaca
tttgtatcgggtaaattaacaattgataactttagatgggctggagttcctttctacatt
agaacgggtaaacgtatgaaatcaaaaacgatacaagtcgtagtagaatttaaagaagta
cctatgaatttatattatgaaactgacaatttactagattctaatttgctagtcattaat
attcaaccaaatgaaggaatttcattgcatttaaatgctaaaaagaacattcaaggaatt
gatactgagccagtgcaattatcatacgcaatgagtgctcaagataaaatgaatacagtt
gatgcatatgaaaacttattgtttgattgtcttaaaggtgatgcgactaattttacacat
tgggaagaattaaaatctacttggaaatttgtagatgcaatccaagatcaatggacaatg
gttgaaccatgtttccctaactatgaagcgggtacgaatggacctcttgaaagtgatctt
ttattaagtcgtgatggaaatcattggtgggatgatatccac
255.
atgattaaaaaaaacaaagaagaactgaatgacatggagtatctagtcactcaagaaaat
ggtactgaacctccgtttcaaaacgagtattggaatcactttgaaaaaggaatttacgtt
gataaattgtccggcaaaccattatttacttcagaggataaatttgaatctaattgcggt
tggccaagtttctccaaagcattaaatgatgatgaaatcgtagaacttgttgataaatca
tttggtatgattagaactgaagttcgatcagaaaaagcaaatagtcacttggggcatgtt
tttaatgacggacctaaagaaaaaggtggtttaagatactgtattaactctgctgcgatt
cagtttataccttatgataaactagaagagttaggatatggagatttaattaaacatttt
aaaaaat
256.
ttgaaaaagttagcctttgcaattacagccgcttcaggcgcagcagcagttctatcacat
catgatgctgaagcttctacacaacataaggttcaatctggagaatccttatggactatt
gcacaacaatacaatacttcagtagaaagcattaagcagaataataatcttagcaacaat
atggtattcccaggacaagttattaatgtaggtggaagtgcttcacaaaatactagttca
aacacttcttcaagttcagcatcttcacatactgtagtagcaggtgaatcattaaacatc
atagctaataaatatggtgtttcagttgatgcattaatgcaagcaaatcatctaaatggt
tatttaattatgcctaaccaaatattaactatccctaatggtggttctggttcaggatca
ggtggtacagcaactcaaactagcggtaattatacttcaccttcattcaaccatcaaaac
ttatacactgaaggtcaatgcacatggtatgtgttcgacaaacgttcacaagctggtaaa
cctatcagtacttactggtctgatgcaaaatactgggcgtcaaatgcagcgaatgatggt
tatcaagttgataatactccatctgttggtgcaattatgcaaagtacacctggaccatat
ggtcatgtagcatacgttgaacgtattaatggtgatggtagtattttaatttcagaaatg
aattatgcaaatggtccatacaatatgaactatcgtactatcccagcttcagaagtatct
tcatatgcatttatccactaa
257.
atggcacgtattgctacaaaattgggctatcctgaaagcaatagtttcgtgactaatact
gtaattgaatttgttttacataacgaagcatatcctcggttatataggattaaaactcga
gatacgaacttaataaaaatttctcaagctaatgaaatctcacgtcaaattacaaatggc
acgatgacgcttgaagaagctaagtatcaattagaggaaatatatgttgctaaaagagat
agcagtctacccttcaaaggaattgccgcagcaattatcgctacgagcttcctctatcta
cagggaggtcgtctggttgatatcatcacagctgtattagctggaacgattggatactta
gtagtagaaatattagatcgaaagctacacgcacaatttattccagaatttataggttct
ttggtaataggtattatttctgtaattggacatgcatttgttcctagcggagatttagct
acaattatcattgccgcggtcatgcctattgtacctggagtacttattacaaatgctatt
caagatttattcggaggacatatgttaatgtttacaacaaaatctttagaagctttagtt
actgcctttggtataggcgctggtgtaagttcaatattaattttagtc
258.
atgacagaatttgacttatccactagagagggtcgttggaaacatttcggttctgttgac
cctgtcaaaggtacgaaaccaactactaaaaatgaaatgaccgatttacaaagcactcac
aaaaatttcttatttgaaatagaggaagtaggcattaaaaatttaacttatccagtttta
attgatcagtatcaaacagctggtttatttagtttttcaacgagtttaaataaaaatgaa
aaaggcattaatatgagtcgcatattagaaagcgttgaaaaacattatgataatggcatt
gaacttgaatttaacacactacatcaattgttgcgtacgctacaagataagatgaatcaa
aatgctgcaggtgttgatgtgtcaggtaaatggttctttgatcgttatagtcctgttaca
catattaaagctgtaggtcatgcagatgttacttatggtttagctattgaaaatcatacc
gttacacgtaaagaattaactattcaagccaaagtaacaacactatgtccttgctcaaaa
gaaattagtgaatattctgcacataatcaacgtggtatcgttacagttaaagcatattta
gataaaaataatgacgtcatcgatgattataaaaataaaattttagacgctatggaagcc
aacgctagttctatcttatatccaatcttaaaacgtcctgatgaaaaacgagtaacagaa
cgtgcttatgaaaacccacgatttgttgaagatttaattcgactaattgcagcagactta
gttgaatttgattggattgaagggttcgatattgaatgtcgtaatgaagagtctatccac
cagcatgatgctttcgcacgtctgaaatatcgcaaa
259.
gtgcaaaaaaaatatattactgccattattggaacaactgcccttagcgcattggcatca
actcatgcacaagctgcaacaacgcatacagtaaaaagtggagaatctgtatggtcaatt
tctcacaaatatgggattagtattgctaaattaaaatcacttaatggattgacttccaat
ttaatattccctaatcaagtattgaaagtatcaggctcatcttcaagagcaacgtcaaca
aatagtggcacagtttatacagttaaagctggagattcattatcttctattgctgcaaaa
tacggtacaacttatcaaaaaatcatgcaacttaatgggttaaataactatcttattttc
cctggacaaaagttgaaagtttctggtaaagcgacgagttccagtcgtgcaaaagctagt
gggtctagtggtcgtactgcaacatatactgttaagtatggagactcactatctgcaatt
gctagtaaatatgggacaacgtatcaaaaaattatgcaattaaatggattaactaatttc
tttatctatcctggacagaagttaaaagtgcctggaggtagttctagtagctcatcttct
aataatactagatcaaacggtggctattattcaccaacttttaaccatcaaaacttgtat
acttggggacaatgcacatggcacgtatttaatagacgtgctgaaataggaaaaggtatc
agtacatactggtggaatgcaaataattgggacaatgcatcagctgctgatggatatact
attgattatcgtcctacagtaggctcaattgcacaaactgacgctggttactatggtcac
gtagcgtttgtagagcgcgtgaatagcgatggaagtattttagtttcagaaatgaactgg
agtgcagctcctggaaatatgacatatagaacaattccagcttatcaagtgagaaattac
aaatttattcatt
260.
gtgaccaaaaaagcttttatttcttattctagaacaagtgatgaacatttaaatagagtt
gtgagaataggagaaagtttgagagttgatcatggaattgatgttattttagatgtatgg
gattgcactgagggagatgacttgaatttttttatggagtctatggttaatgacgagacg
atagattttgttattatattaagcgattttcagtattttaatagagctaatgatagagaa
ggaggagttggaaaagaaagcacaataattacttctcaaatttatgataagcaaaaagat
agtaagtttatacctgtctttttagatattctggataatggaaaaccatcattaccaact
ttttgtaatactagattcgctattgatatgacagacatcgaattagatatagagaaaata
gaagagattgcaagaaaaatacacgataaacctttattcgaaaaaccaagacttggtaaa
gtaccagattataaccaaaatcaaaatgagttaaagaaagcaataaaaaaattaacttta
tctaaaagttataatgaaacgagaaattttgaagaagctttagacattatttataaaact
ttagaaaatatagaaaatagcgtagaggaatataataaagatgatttaatgactttaaaa
gaggtttttgatacttggaaagaatttattacgtatgcgctaaacaatgataacttttat
tttagggaattaatcatagagcattataataggtgcttaaagcttacggaagaagaattt
gaaaatccaatgactaggatttttaattatttttcatttcttatactagtaagtgaatct
ttatcttcaggagcaaatgaatttttgaaagatttattgaatgctaaatttcattttagt
agaagagaagcaaattattatatattaagtttatatccccaggtgttatccaagaaatat
tcatataatactaatgtcaaaaaaatgttagccgaaatgtactttgaagggaaggagtta
aaaaaggttcaagatgcagatgtaattttatatacagaaagtcttatgaaaaaagatatt
catagtgtatatgaaacgtggcatggggttctgttgtatagtagatggcctatgcttgag
caacaaactattaatattttaataaataaatttcgtagtaaaaaatatctagatcaattt
gactttttatttggaagttcacaaagagaagtatttgaaaactatgataagattaaatcc
acacaagaaatacctactatttttaattttattgataaagaagaaattggcagctat
261.
atgcactatctaaagaaagtaactatatacataagtttattaattttggtgagtggttgt
ggagacagcaaagaaacggaaatcaaacaaaactttaataaaatgttaaatgtgtatcca
actaaaaatctagaagacttttatgataaagagggttatcgtgatgaagagtttgataag
gatgacaaaggaacatggattattagatctgaaatgacaaaacagccaaaaggtaagatt
atgacttcaaaaggtatggtgttacatatgaatagaaatactagaagtacaactggttat
tacgttattaggaaaatttctgaagataataaaagtgaaattgatgatgaagaaaagaaa
tatcctataaagatggtaaataacaagataattccaactcaaaaaattaatgacaataaa
ttgaagaatgaaatagaaaactttaagttctttgtacaatacggaagctttaaaaattca
gatgattataaagaaggggatattgaatacaatcctaatgcaccaaattattctgcacaa
tatcatttaagtaatgatgactataatattaaacaattaagaaaaagatatgatattaaa
acgaaaaaaactcctagattattaatgagaggcgctggagatccaaaaggatcttctgta
ggttataaaaatcttgaatttacatttgttaagaataatgaggaaaatatttattttacc
gatagtattaattttaatccaagcaagggtaaatcattg
262.
gtgaaacattcgaaaaagttacttttatgcatcagttttttattaataacgttttttatt
ggtggatgtggatttatgaataaagacgatggtaaagaaacggaaatcaaacaaaacttt
aataaaatgttaaacgtgtatcccactaaaaatctagaaaacttttatgataaagagggc
tatcgagatgaagagtttgataaggatgacaaaggaacatggatagttcattctaaaatg
gttattgaaccaaaaggcaaaaacatggaatctagagggatggttctctttatcaatcgc
aatactagaacatcaaaaggctattttatagtcaatgaaatagaaaaggatagaaaagga
agacccattaataataaaaagaaatatcctgtaaaaatgaaaaataataaaattattcca
accaaaccaatatctaatgataaattaaaaaaagaaattgaaaactttaaattttttgta
caatatggcaattttaaagatattaaaaattataaagatggtgacatttcatacaatcct
aatgtacctagttattctgcaaaatatcaattgagtaataatgaatataacgtacaacaa
ttaagaaaaagatatgacatcccaactaaaaaagtacctaaactattgttgaaaggtgat
ggggatttaaaaggttcatccgtaggttctaaaaatctagaatttacttttatagaaaat
aaagaagagaatatctattttacagattctgtactatttagccctagcgaggataatgaa
tca
263.
atgcgttatctcaagaaagtaacgatatacataagtttattaattttggtaagtggttgt
ggaaacggtaaagaaacggaaatcaaacaaaactttaataaaatgttagacatgtatccg
actaaaaatctagaagacttttatgataaagaaggctatcgagatgaagagtttgataaa
aaggataaagggacatggatagttggatctaccatgacaattgaaccaaaaggcaagtac
atggaatctagaggtatgtttctatatattaatcgcaatactagaacaactaaaggttat
tattatgtgaggaaaacaacagatgacagtaaaggtagactaaaagatgatgaaaagaga
tatcctgtaaaaatggaacacaataaaattattccaacgaagccaatacctaatgacaaa
ctaaaaaaagaaatagaaaacttcaaattttttgtacaatatggagattttaaaaactta
aaggattataaagatggtgacatttcatacaatcctaatgtacctagttattctgcaaaa
tatcaattgagtaataatgactataatgtaaaacaattacgaaaaagatatgatattccc
accaaccaagcccctaaattattgttaaaaggagatggtgacttaaaaggctcatctata
ggttccaaaagtttagaatttacttttatagaaaataaagaagagaatatctttttttca
gatggtgtacaatttactcctagcgaggatagtgagtca
264.
atgaaacattcaagcaaaataatagtatttgtaagtttcttaattttaacgatttttatt
ggaggatgtggttttataaataaagaagatagcaaagaagctgaaatcaaacaaaacttt
aataaaacgttaagtatgtatccaactaaaaatctagaagacttttatgataaagagggc
tatcgtgatgaagagtttgacaaagatgacaaagggacatggattattaattctaaaatg
attgttgaaccgaaaggggaagagatggaagcaagagggatggttttacgtataaataga
aatacgagaacagctaaaggtaactttattataaaacgaataacagaaaataataaagga
atacctgatgttaaagacaaaaaatatccagtaaaaatggaacacaataaaattattcca
acaaaacaaattaaagataaaaaattaaaaaaagaaattgagaacttcaaattttttgta
caatatggaaattttaaaaacttaaaggattataaagacggagagatatcttacaatcct
aatgtgccaagttactcagcgcaatatcaattgaacaattatgataataatgttaaacaa
ctaagaaaaagatatgatattcccacgaatcaagctcctaaattattattgaaaggtaca
ggagatttaaaaggatcctctgtaggttataaacatcttgaatttacttttgtagaaaat
aaaaaggaaaatatttattttactgacagtataaactttaacccgagtagggggaat
265.
atgcgttatctcaagaaagtaactatatacataagtttattaattttaacgatttttatt
ggaggatgtggttttataaataaagaagatagcaaagaaacggaaatcaaacaaaacttt
aataagatgttaaacgtgtatcctactaaaaatctagaagacttttatgataaagaaggt
tttcgagatgaagaatttgataaaggagataaaggaacttggattattaggtctgaaatg
acaaaacagccaaaaggtaaaattatgacctcaagaggtatggttctctatatcaatcgt
aacactagaacagccaaagggtattttttaatagatgagataaaagatgataatagtggt
agaccgatagagaatgaaaagaaataccctgtaaaaatgaaccataataagatctttcca
acaaagccaatatctgatgataaattaaaaaaagaaattgaaaacttcaaattttttgta
caatatggagattttaaaaacttaaaggattataaagacggagagatatcttacaatcct
aacgttcctagttactcagcgcaatatcaattgaacaataatgataataatgttaaacaa
ttaagaaaaagatatgatattccaaccaatcaagcccctaaattattgttaaaaggggat
ggcgacttaaaaggatcatctgtaggttctaaaaatttagaatttacttttgtagaaaat
aaagaagagaatatattttttacagatgcagtacaattcactcctagcgaggatgatgaa
tca
266.
atgaagacctataagccgtaccgacatcaattaaggcgttcgctatttgcctcaacgatt
ttcccagtatttatggtgatgattattggtttaataagcttttatgctatttatatatgg
gtcgaacatcgcaccattcatcagcatacctatcaaactcaaaccgaattacaacgtatc
gacaaacattttcatacgtttgttacgcagcaacaaaaacaatggcgtcatgttgattta
tcacatccaactgatatcacaaagatgaaacgccaactattaaaacaagtccatcaacaa
cctgcgatattgtattacgatttaaaaggttcttcacaatctttcacaaacaattatgaa
caattagacacaacaaagatgtatttaatatcaaaatatcgaattgattttaaagacgat
acttatatccttaaaatatatatgtcaagcacaccactacttaaaaacattaagaaaaat
agtggacaatctgcactcattgttgattcatatgatactgttttatatacaaatgacgac
cgattctctatcggtcaaaaatatcaaccaccacagtttgggtttatgaacgagtcttta
aaactcaattctcatcatgcgcatcttattatatataaagatattcatgaaaccattgaa
gatggaattgcattactagttgtcatgggtgttgttcttattctgcttgttatttttgga
tatataagcgctgatagaatggcaaagcgccaatctgaagatattgaagcgattgtccga
aaaattgatgatgctaaaaatcgacatcttggtagttacgaaccgttaaaaaaacatagt
gagttagaggaaataaataattatatctatgacttgtttgaatcaaatgagcaattaata
caatctattgaacagaccgaacgtcgtttacgtgatatacaattaaaagaaattgagcga
caatttcaaccccatttcttattcaatacgatgcaaacgatacaatatttaattcctctt
tcacccaaagtagcacaaacagtcatacaacaactatcacaaatgctacgttattctcta
cgcacagcatcgcacacagtcaaattagcagaagaattaagctacattcagcagtatgtt
gctatacaaaatatccgcttcgatgatatgatacagctttacatcgatgctcctgaagat
gtacaacatcaaacaattggtaagatgatgcttcaaccactcgtagaaaatgccatcaag
catggtcgtggtagtgaacctttaaagataacaattcgtatcagacttacgaagcgcaaa
ttacatattctggttcatgataatggcatcggtatgtctccatcacatttagaacgcgtg
cgccaatcacttcatcacgatgtttttgatacgacacacctaggtttaaatcatttacat
aatagagccatcattcaatatggaacatatgcacgtctgcacattttctcaagaagccat
caagggacattaatgtgttaccaaataccacttgtc
267.
gtggatgatgtgacaaaatatggtccagttgatggagatccgattacgtcaacggaagaa
attccgtttgataaaaaacgcgaatttgatccaaacttagcgccaggtacagagaaagtc
gttcaaaaaggtgaaccaggaacaaaaacaattacaacaccaacaactaagaacccatta
acaggagaaaaagttggcgaaggtgaaccaacagaaaaaataacaaaacaaccagtggat
gagatcgttcattatggtggcgaagaaatcaagacaggccataaggatgaatttgatccg
aacgcaccgaaaggtagtcaaacaacgcaaccaggtaagccaggagttaaaaatcctgat
acaggcgaagtagtcacaccaccagtggatgatgtgacaaaatatggtccagttgatgga
gatccgattacgtcaacggaagaaattccgtttgataaaaaacgcgaatttgatccaaac
ttagcgccaggtacagagaaagtcgttcaaaaaggtgaaccaggaacaaaaacaattaca
acgccaacaactaagaacccattaacaggggaaaaagttggtgaaggtgaaccaacagaa
aaaataacaaaacaaccagtggatgagatcgttcattatggtggcgaagaaatcaagcca
ggccataaggatgaatttgatccaaacgcaccgaaaggtagccaagaggacgttccaggt
aaaccaggagttaaaaatcctgatacaggcgaagtagtcacaccaccagtggatgatgtg
acaaaatatggtccagttgatggagatycgattacgtcaacggaagaaattccgtttgat
aaaaaacgcgaatttgatccaaacttagcgccaggtacagagaaagtcgttcaaaaaggt
gaaccaggaacaaaaacaattacaacaccaacaactaagaacccattaacaggggaaaaa
gttggcgaaggtgaaccaacagaaaaaataacaaaacaaccagtagatgaaatcacagaa
tatggtggcgaagaaatcaagccaggccataaggatgaatttgatccgaacgcaccgaaa
ggtagccaagaggacgttccaggtaaaccaggagttaaaaatcctgatacaggcgaagta
gtcacaccaccagtggatgatgtgacaaaatatggtccagttgatggagatccgattacg
tcaacggaagaaattccgtttgataaaaaacgcgaatttgatccaaacttagcgccaggt
acagagaaagtcgttcaaaaaggtgaaccaggaacaaaaacaattacaacaccaacaact
aagaacccattaacaggagaaaaagttggcgaaggtgaaccaacagaaaaaataacaaaa
caaccagtggatgagatcgttcattatggtggcgaagaaatcaagacaggccataaggat
gaatttgatccgaacgcaccgaaaggtagtcaaacaacgcaaccaggtaagccaggagtt
aaaaatcctgatacaggcgaagtagtcacaccaccagtggatgatgtgacaaaatatggt
ccagttgatggagatccgattacgtcaacggaagaaattccgtttgataaaaaacgcgaa
tttgatccaaacttagcgccaggtacagagaaagtcgttcaaaaaggtgaaccaggaaca
aaaacaattacaacgccaacaactaagaacccattaacaggggaaaaagttggtgaaggt
gaaccaacagaaaaaataacaaaacaaccagtggatgagatcgttcattatggtggcgaa
gaaatcaagccaggccataaggatgaatttgatccaaacgcaccgaaaggtagccaagag
gacgttccaggtaaaccaggagttaaaaatcctgatacaggcgaagtagtcacaccacca
gtggatgatgtgacaaaatatggtccagttgatggagattcgattacgtcaacggaagaa
attccgtttgataaaaaacgcgaatttgatccaaacttagcgccaggtacagagaaagtc
gttcaaaaaggtgaaccaggaacaaaaacaattacaacgccaacaactaagaacccatta
acaggagaaaaagttggcgaaggtgaaccaacagaaaaaataacaaaacaaccagtggat
gagattgttcattatggtggtgaacaaataccacaaggtcataaagatgaatttgatcca
aatgcacctgtagatagtaaaactgaagttccaggtaaaccaggagttaaaaatcctgat
acaggtgaagttgttaccccaccagtggatgatgtgacaaaatatggtccagttgatgga
gattcgattacgtcaacggaagaaattccgtttgataaaaaacgcgaatttgatccaaac
ttagcgccaggtacagagaaagtcgttcaaaaaggtgaaccaggaacaaaaacaattaca
acgccaacaactaagaacccattaacaggagaaaaagttggcgaaggtaaatcaacagaa
aaagtcactaaacaacctgttgacgaaattgttgagtatggtccaacaaaagcagaacca
ggtaaaccagcggaaccaggtaaaccagcggaaccaggtaaaccagcggaaccaggtacg
ccagcagaaccaggtaaaccagcggaaccaggtacgccagcagaaccaggtaaaccagcg
gaaccaggtaaaccagcggaaccaggtaaaccagcggaaccaggtaaaccagcggaacca
ggtacgccagcagaaccaggtacgccagcagaaccaggtaaaccagcggaaccaggtacg
ccagcagaaccaggtaaaccagcggaaccaggtacgccagcagaaccaggtaaaccagcg
gaatcaggtaaaccagtggaaccaggtacgccagcacaatcaggtgcaccagaacaacca
aatagatcaatgcattcaacagataataaaaatcaattacctgatacaggtgaaaatcgt
caagctaatgagggaactttagtcggatctctattagcaattgtcggatcattgttcata
tttggtcgtcgtaaaaaaggtaatgaaaaat
268.
mtkkekdykksleqqktrvkiyksgkswvkasineiellktmglpflskneiqenvtekt
kghklkksaakttalvggaftfnmlnnhqafaasetpitseissnsetvanqnsttikns
qketvnstslesnhsnstnkqmssevtntaqssekagisqqssetsnqssklntyastdh
vesttinndntaqqdqnkssnvtskstqsntssseknissnltqsietkatdslatsear
tstnqisnltststsnqssptsfanlrtfsrftvlntmaaptttsttttssltsnsvvvn
kdnfnehmnlsgsatydpktgiatltpdaysqkgaislntrldsnrsfrfigkvnlgnry
egyspdgvaggdgigfafspgplgqigkegaavgigglnnafgfkldtyhntstprsdak
akadprnvggggafgafvstdrngmatteestaaklnvqptdnsfqdfvidyngdtkvmt
vtyagqtftrnltdwiknsggttfslsmtastggaknlqqvqfgtfeytesavakvryvd
antgkdiippktiagevdgtvnidkqlnnfknlgysyvgtdalkapnytetsgtptlklt
nssqtviykfkdvqgpqisvdsqtrevgktinpititttdnskdvltttvtglpsglsfd
qttntiigtpsevgtttvtvnttdatgnvtskqftitiqdtispvvnvtpsqasevftpi
npititatdnsgkvvthtvtglpqglkfdastnsivgtptqigtntitiestdasgnktt
tkinyevtrnsasdststsivnsvstsisnstslsdsvkasqslstkestskslsgslsa
stsnsasikasesastskklsesastsmsdsasikasesastskklsesaststsdsasi
kasesastskklsesastsmsdsvsikasesastskklsesaststsdsastqasesast
skklsestststsdsaststsesdstsestslsdstsaslsestststsdsaststsesd
snststslseststslsestststsdsastsasvsdsnsastslreststslsdststst
sdsaststsesdsdsastslsgssstsvsdstsastsesaststsisdsnststslsest
stslsestststsdsastsmsvsdsnsasislseststsvsdstststsesaststsesd
snsastslseststsvsdstststsdsaststsvsdsnsastslseststsisdststst
sdsaststsvsessstskklsesastsmsdsasastsesnststslsgststslsgstst
stsesaststsvsdsnsastslseststslsdstststsdstsastsesdsnststsmse
slstsvsdstststsdsaststsvsdsnsastslsdststsisdstsastsdsasesase
sestsestsvsessstsvsdstststsesaststsesestsestsvsessstsvsdstst
stsesaststsesestsestslsgssstsvsdstststsesaststsvsdsnststslse
ststslsnstststsdsaststsvsdsnsastslsgslstnvsdstststsdsaststse
sdsnsastslsgslstsisdstststsdsaststsesaststsvsesdsestsmsvsdsn
ststslsdststsvsdstrtstsdsastsksvsesnsastsvsgststsisdssststsm
stsetftsqspinsesqfigdslsedtivtqskntnmlnktgkdydlqeqrgytdseqhn
etqsnqadnhsnnldllhqnrlqdkvvkqptkgedgvvsngfivavaivlaifglakksr
kddddqdgsk
269.
mkktviastlavslgiagyglsgheahasettnvdkahlvdlaqhnpeelnakpvqagay
dihfvdngyqynftsngsewswsyavagsdadytesssnqevsantqssntnvqavsapt
ssesrsyststtsysapshnysshsssvrlsngntagsvgsyaaaqmaartgvsastweh
iiaresngqlharnasgaaglfqtmpgwgstgsvndqinaaykaykaqglsawgm
270.
mnknkvivigstnvdkflnvkrfpkpgetlhinqaqkefgggkganqaiaasrlaadttf
iskvgkdgnanfiledfkkagihtqyiltseseetgqafitvdeagqntilvygganmtl
satdvemsvdafigadfvvaqlevpfeaieqafkiarkqnittvlnpapaielpksllel
tdiiipneteaelltgisinnesdmketatyfldlgisavlitlgeqgtycayqeqykmi
pacnvkaidttaagdtfigaflselnkdlsnlesairlanqassltvqrkgaqasiptrk
eveaeyn
271.
malkkykpitngrrnmttldfaeitkttpeksllqplpkragrnnqgkltvrhhggghkr
qyrvidfkrnkdgiiakvdsiqydpnrsaniallvyadgekryiiapkglqvgqtvesga
eadikvgnalplqnipvgtvihnielkpgkggqlarsagassqvlgkegkyvlirlrsge
vrmilstcratigqvgnlqhelvnvgkagrsrwkgvrptvrgsvmnpndhphgggegrap
igrpspmspwgkptlgkktrrgkkssdklivrgrkkk
272.
mkskftillftifsttvlvlviiynktqsqsyisthysnnkikttatlflhgyggserse
tfmvkqalnknvtnevitarvssegkvyfdkklsedaanpivkvefkdnkngnfkenayw
ikevlsqlksqfgiqqfnfvghsmgnmsfafymknygddrhlpqlkkevniagvyngiln
mnenvneiivdkqgkpsrmnaayrqllslhkiycgkeievlniygdledgshsdgrvsns
ssqslqyllrgstksyqemkfkgakaqhsqlhenkdvaneiiqflwet
273.
mkigidaggtlikivqehdnrryyrtelttniqkvidwlnneeietlkltggnagviadq
ihhspeifvefdasskgleilldeqghqiehyifanvgtgtsfhyfdgkdqqrvggvgtg
ggmiqglgyllsnitdykeltnlaqngdrdaidlkvkhiykdteppipgdltaanfgnvl
hhldnqftsanklasaigvvgevittmaitlareyktkhvvyigssfnnnqllrevveny
tvlrgfkpyyiengafsgalgalyl
274.
mtlnnhfaytfeerptpklwlckpdgtrieriadfsklggtfkftnvntlhfdlplqvfs
edtkqiernkvvdlvknkylidyryngyrdifviddikksandsdfitlnldsraselnk
kaaneiellgstipqmmnkilsvyaplwklghvdgkiidvkreltgsnttvnalidnics
lfdavaiynninrtisfyhkdnvgtnrglrvrensylksfedqfvskdivtrlypfgqsg
ltiqsvnpagssyiedfsyfmspfkrdnnrnvlqhsdymsdelchalldyqefyaskkdq
agelskqysailkehsqedfrlnqlsatlqrlnervelvkpkseyidlgtkvknfkitvp
kssyylimirndgsftrikfnnkqydipsgewlyiklktgkfndatkfekqleypleils
ananlrvvytrssegdyeeedtktieekynlekykilvkdqekvvasierrlkafedqka
svirsmnaknflseklynerelyvfesvwteenhtdaqelyddavkqmkeqkkinrtitv
dlvnfiqsldhkddwdklnvgdkvvfqnkifntkikayitemqldfqtnqvkitisdifd
ykdldtiiaeklaqttstssqvdfhkqqireqtgritdmtrliegewdankkrvmagnet
vdigshgvkviskenpnefvimvggviamtrdngetfktgitpeginaemligkmivget
ltfenesgtvkfdkdglyvnsknfhlvsndgeedyfdklkremsenakqqtdrmleeykk
evsqtiseatdvrnivdnaadilqaafadgvitdvekrlisetlaqlekenrefedkinl
alnhpyiteedtielnnsiveyssmyetlvisinesvsdkmitpqeseeinqniinfree
ikdilslveeiiertknaqlqatleeakdyttrvrddikdelkdlnnsfkslnstveesl
qdnifdaaeleaiktvvlvtkseyqditnryssmsantdlkseskldltksyktldtsfn
dfvkyidemtmdriadetekvnykkkydtlqknlsdymkkydncileiskkysndaadkv
lgdftaiatelqndfqdvkdnwaefkqttlesfkdgivteaekarlrvqldmldresmdi
eeryksllanqytntdiknrltasrspylsvhaslrkvieqiiadgkvdesektlannsl
ntynttltaysktiqealntlsqiissdvaskkveefngvittissdvdtikkqrdgavi
tyyysgvptlsndpakswttndlkdlhikdmyldtksgyaytftksgtsyswkpltdqvi
vsslkqaknaqdtadnkrrvfvtqpippydqgdmwtqgsqgdiyvcgtsratgsfvssdw
vkaskytddtvakqaakdledykvkmtkdfkdlndgvstfktevvkdfkdgivteaektr
lrvqldildresqdieerynsifnsqyadtqvktsisnarstynnsltklrntiqtvied
gkvtptekttanqtltaynnaltsysaaiqealnsmskviaqkeatsqvnqfneviknin
tnitdiqkqvdgaietfyysgvptltnipasywttaskreahlgdlyldtatgvayrflk
kgttsptyywspisdqiitdalnraktaqdtadgkrrvfvntpvppydtgdmwtqgasgd
ilvcktpkakggiysisdwvkaskytddtvansavqqlneykrtnnldiadlkrktsdfe
ktvvnafddrvisisesssikgqlallnhekdrltrqyeniirnsnlvgaektklstays
nintklsdlsttinsaivdnkivdaesksvtskfelykasvneyqiafdnalnsiireia
ssqakdrldewkrtefstdsdgiiervagakfdskwtdtwrntvnpaiqqvsnitygsen
lllnsesrsdganttthsfiryyltrpletgktytlkasvlttderqsgqisvypyspng
aretvnikdgkitytftaqtestqfliykdvagqsdvdlnvtiekailvegnkvtgwspa
peetssalrdyntrissaetfieknkekisqiatksdvdaslskvatyetqynvssgtny
qiplqeyngsfftdnytyevvaknnslssnnvataifvskgsnngyelveldnmsktgan
prfvldskgrpsistfspqsttqdisviytkylgsasainttkslieqtassielqvkkl
taeteynnillnsdfssgwegwinvdpqysivdkntfgitlpdaitnknkkyntvkmtyn
kntnypsvfsnfisvgkgqevaigehltltcyayipssskgkltgniyiefagyyekdqk
snpmiarheilpkdfeynkwfrmtastaipstnsegkkinyiraclrydgknqsvnnsai
fyyalpqlergskptewslsrldvfsteqlaakialnpesvdiiarnidfntdsmkiyns
ngtlnisgdtltisnnnssneviinpkgftlkkdgvvkfkngldtsdysvqayepqfssw
nnikatdpaakskynyirhiepgmngyytintgvynfavqhkqllevnntknarvnryty
lynkrylkiqmsassrgksklyiifktktgdttlhqeivssssmvypditidlqaklgyp
pnnlpdffelqagiaygennsidgffrirrmamtdtpnaev
275.
mynvtqhatyktknkretavligvhaqtdrqfnfestmeeldalsqtcqlnvkgqitqnr
eqfdhkyyvgkgkideiksfiefhdidvvvtndelttaqsktlndnlgikiidrtqlile
ifalrarsregklqvelaqldyllprlhghgkslsrlgggigtrgpgetklemdrrhirt
rmneikhqlktvvdhreryrnkreqnqvfqialvgytnagksswfnvlaneetyeknilf
atldpktrqiqvnegfnliisdtvgfiqklpttlvaafkstleeakgadvlmhvvdashs
eyrtqidtvnqiindldmdhipqvvifnkkdlcneqmdvpvsksahvfvssrdendkqkv
knlviqeiknslspyeeivdsadadrlyflkqhtlvtelifdetqasyrikgfkkl
276.
mmiivmlilsyligafpsgliigklffkkdirqygsgntgatnsfrvlgrpagfivtfld
ifkgfitvffplwfpvhadgvistfftnglivglfailghvypiylkfnggkavatsagv
vlgvnpilllilaiiffsvlkifkyvslssiiaaiscvigsiiihdyillavsgivsiil
iirhksnivrifkgeepkikwm
277.
mmnhsealteqvfsfaselyaygvrevvispgsrstplalvfeahpniktwihpdersaa
ffalglikgsekpvailctsgtaaanytpaiaesqisrlplvvltsdrphelrsvgapqa
inqvnmfsnyvnfqfdlpiadgsehtidtinyqmqiasqylygphrgpihfnlpfreplt
pdldrvdlltsvtktlphyqksisvddikdilqekngliivgdmqhqavdqiltystiyd
lpiladplsqlrkekhpnvittydllyraglnlevdyvirvgkpviskklnqwlkktday
qiivqnndqidvfptpphisyeisandffrslmeeplverkkwlqqwqsleqqarieisd
ylkhatdeaayvgsliqkltkedtlfvgnsmpirdvdnllfdseasvyanrgangidgvv
stalgmaahknvtlligdlsfyhdmngllmaklnelhinivlvnnngggifsylpqkrsa
tkyferlfgtptglnfeytallydftfkrfdnltdfkyaelskmgshmyevitnrdenlh
qhqnlyqklseivnvtl
278.
makkfnyklpsmvaltlfgtaftahqanaaeqpqnqsnhknvlddqtalkqaekaksevt
qsttnvsgtqtyqdptqvqpkqdtqsttydasldemstyneissnqkqqslstddanqnq
tnsvtknqqeetndltqedktstdtnqlqetqsvakenekdlgananneqqdkkmtasqp
senqaietqtasndnesqqksqqvtseqnetatpkvsntnasgynfdyddedddsstdhl
epislnnvnatskqttsykykepaqrvttntvkketasnqatidtkqftpfsataqprtv
ysvssqktsslpkytpkvnssinnyirkknmkaprieedytsyfpkygyrngvgrpegiv
vhdtandnstidgeiafmkrnytnafvhafvdgnriietaptdylswgagpygnqrfinv
eivhthdydsfarsmnnyadyaatqlqyynlkpdsaendgrgtvwthaaisnflggtdha
dphqylrshnysyaelydliyekyliktkqvapwgttstkpsqpskpsggtnnkltvsan
rgvaqikptnnglyttvydskghktdqvqktlsvtktatlgnnkfylvedynsgkkygwv
kqgdvvyntakapvkvnqtynvkagstlytvpwgtpkqvaskvsgtgnqtfkatkqqqid
katylygtvngksgwiskyylttaskpsnptkpstnnqltvtnnsgvaqinaknsglytt
vydtkgkttnqiqrtlsvtkaatlgdkkfylvgdyntgtnygwvkqdeviyntakspvki
nqtynvkpgvklhtvpwgtynqvagtvsgkgdqtfkatkqqqidkatylygtvngksgwi
skyyltapskvqalstqstpapkqvkpstqtvnqiaqvkannsgirasvydktaksgtky
anrtflinkqrtqgnntyvllqdgtsntplgwvnindvttqnigkqtqsigkysvkptnn
glysiawgtknqqllapntlanqafnaskavyvgkdlylygtvnnrtgwiaakdliqnst
daqstpynytfvinnsksyfymdptkanryslkpyyeqtftvikqkningvkwyygqlld
gkyvwikstdlvkekikyaytgmtlnnainiqsrlkykpqvqneplkwsnanysqiknam
dtkrlandsslkyqflrldqpqylsaqalnkllkgkgvlenqgaafsqaarkyglneiyl
ishalvetgngtsqlakggdvskgkfttktghkyhnvfgigafdnnalvdgikyaknagw
tsvskaiiggakfignsyvkagqntlykmrwnpanpgthqyatdinwanvnaqvlkqfyd
kigevgkyfeiptyk
279.
vafefrlpdigegihegeivkwfikagdtieeddvlaevqndksvveipspvsgtveevl
vdegtvavvgdvivkidapdaeemqfkghgddedskkeekeqespvqeeasstqsqekte
vdesktvkampsvrkyarengvnikavngsgkngritkedidaylnggsseegsntsaas
estssdvvnasatqalpegdfpettekipamrkaiakamvnskhtaphvtlmdeidvqel
wdhrkkfkeiaaeqgtkltflpyvvkalvsalkkypalntsfneeagevvhkhywnigia
adtdkgllvpvvkhadrksifeisdeinelavkardgkltseemkgatctisnigsaggq
wftpvinhpevailgigriaqkpivkdgeivaapvlalslsfdhrqidgatgqnamnhik
rllnnpelllmeg
280.
mnetdeisqiynkhrlpslsglakvsplvhrasiggvlnvaelnrikrlvqvqnqfktfy
nqmleedeevkypilhdkmnhlpiltdlfkeinetcdahdlfdhasytlqsirskisrtn
qrirqnldrivknqgnqkklsdaivtvrndrnvipvkaeyrqdfngivhdqsasgqtlyi
epnsvvemnnqisrlrndeavererilteltgfvsaeadalliaesvmgqidfliakary
artikgtkptfkedrtiylpnafhplldkdtvvantiefiddvetviitgpntggktvtl
ktlgliivmaqsglliptldgsqlsifenvycdigdeqsieqslstfsshmkniveilqd
adqnslilfdelgagtdpsegaalamsildyvrrlgslvmatthypelkaysynregvmn
asvefdvetlsptykllmgvpgrsnafdiskklglslniinkaktmigtdeqeinamies
leqnskrvdqqrieldrlvreaqqthdalskqyqqyqnyetslmdeakekanqrvksatk
eadeilkelrnlrdhkgaevkehelidkkkqlddqyevksikqhvqkkkydtihtgdevk
vlsygqkgevlelvgdeeavvqmgiikmklpiedlektkkkkekptkmvtrqnrqtikte
ldlrgyryeealneldqyldqavlsnyeqvyiihgkgtgalqkgvqqhlkkhksvrqfrg
gmpseggfgvtvaelk
281.
msffkrlkdkfsskneddiqkdldesvdsnvnsdsdsmdpndsdeqvkpkkkpkklsead
fdedglisiedfeeieaqkigakfkagleksrqnfqeqlnnliaryrkvdedffealeem
litadvgfntvmkltdelrteaqrrniqetedlrevivekiveiyhqeddhseamniedg
rlnvilmvgvngvgktttigklayryqqegkkvmlaagdtfragaiqqlnvwgervgvev
vsqnegsdpaavvydainaaknkdvdilicdtagrlqnksnlmqeldkmkrvinraipda
pheallcldattgqnalsqarsfkevtnvsgivltkldgtakggivlairnelhipvkyv
glgekmddlqpfspesyvyglfadmieqnedipeeisrnssveseegn
282.
mkrnwwkeavayqvyprsfndsngdgigdlpgliekldylenlgidviwlspmypspndd
ngydisdykgimsefgtmndfdqllssihqrgmklildlvvnhtsdehpwfieskssktn
akrdwyiwadpkpdgsepnnwesifngstwefdestkqyyfhlfskkqpdlnwenpdvrq
avfemmnwwfekgidgfrvdaithikknfeagdlpvpdgkkfapafdvdmnqpgiqewlq
emkdkslsrydimtvgeangvtpndaeewvgeengkfnmifqfehlglwstgdtkfdvks
ykqvlnrwqkqlenvgwnalfienhdqprrvstwgddknywyesatshatayflqqgtpf
iyqgqeigmtnypfesiesfndvavkteyqivkkeggdvnqlldkykmenrdnartpmqw
nnsinagfttgkpwfhvnpnyteinvkqqlndkfsilsyykaliqlkksdliytygkfnm
vdaenkqvfaytrtfknntvlivanltnevselnlpfeldissvdiklhnyhlndinldh
ikpyesfvvei
283.
lshrklfpsifhlyqqdnldehiaiigigrrdynneqfrdqvkasiqtyvkdtdridefm
thvfyhktdvsdkesyqsllqfserldsefalggnrlfylamapqffgvisdylkssglt
qttgfkrlviekpfgsdlksaeslnnqirrsfkeeeiyridhylgkdmvqnievlrfana
mfeplwnnkyisniqvtssevlgvedrggyyessgalkdmvqnhmlqmvallameapisl
nsediraekvkvlkslrqlkpeevkknfvrgqydqgnidgkqvksyreedrvakdsvtpt
fvsgkltidnfrwagvpfyirtgkrmksktiqvvvefkevpmnlyyetdnlldsnllvin
iqpnegislhlnakkniqgidtepvqlsyamsaqdkmntvdayenllfdclkgdatnfth
weelkstwkfvdaiqdqwtmvepcfpnyeagtngplesdlllsrdgnhwwddih
284.
mikknkeelndmeylvtqengteppfqneywnhfekgiyvdklsgkplftsedkfesncg
wpsfskalnddeivelvdksfgmirtevrsekanshlghvfndgpkekgglrycinsaai
qfipydkleelgygdlikhfkk
285.
lkklafaitaasgaaavlshhdaeastqhkvqsgeslwtiaqqyntsvesikqnnnlsnn
mvfpgqvinvggsasqntssntssssasshtvvageslniiankygvsvdalmqanhlng
ylimpnqiltipnggsgsgsggtatqtsgnytspsfnhqnlytegqctwyvfdkrsqagk
pistywsdakywasnaandgyqvdntpsvgaimqstpgpyghvayveringdgsilisem
nyangpynmnyrtipasevssyafih
286.
mariatklgypesnsfvtntviefvlhneayprlyriktrdtnlikisqaneisrqitng
tmtleeakyqleeiyvakrdsslpfkgiaaaiiatsflylqggrlvdiitavlagtigyl
vveildrklhaqfipefigslvigiisvighafvpsgdlatiiiaavmpivpgvlitnai
qdlfgghmlmfttkslealvtafgigagvssililv
287.
mtefdlstregrwkhfgsvdpvkgtkpttknemtdlqsthknflfeieevgiknltypvl
idqyqtaglfsfstslnknekginmsrilesvekhydngielefntlhqllrtlqdkmnq
naagvdvsgkwffdryspvthikavghadvtyglaienhtvtrkeltiqakvttlcpcsk
eiseysahnqrgivtvkayldknndviddyknkildameanassilypilkrpdekrvte
rayenprfvedlirliaadlvefdwiegfdiecrneesihqhdafarlkyrk
288.
vqkkyitaiigttalsalasthaqaatthtvksgesvwsishkygisiaklkslngltsn
lifpnqvlkvsgsssratstnsgtvytvkagdslssiaakygttyqkimqlnglnnylif
pgqklkvsgkatsssrakasgssgrtatytvkygdslsaiaskygttyqkimqlngltnf
fiypgqklkvpggsssssssnntrsnggyysptfnhqnlytwgqctwhvfnrraeigkgi
stywwnannwdnasaadgytidyrptvgsiaqtdagyyghvafvervnsdgsilvsemnw
saapgnmtyrtipayqvrnykfih
289.
vtkkafisysrtsdehlnrvvrigeslrvdhgidvildvwdctegddlnffmesmvndet
idfviilsdfqyfnrandreggvgkestiitsqiydkqkdskfipvfldildngkpslpt
fcntrfaidmtdieldiekieeiarkihdkplfekprlgkvpdynqnqnelkkaikkltl
sksynetrnfeealdiiyktleniensveeynkddlmtlkevfdtwkefityalnndnfy
freliiehynrclklteeefenpmtrifnyfsflilvseslssganeflkdllnakfhfs
rreanyyilslypqvlskkysyntnvkkmlaemyfegkelkkvqdadvilyteslmkkdi
hsvyetwhgvllysrwpmleqqtinilinkfrskkyldqfdflfgssqrevfenydkiks
tqeiptifnfidkeeigsy
290.
mhylkkvtiyisllilvsgcgdsketeikqnfnkmlnvyptknledfydkegyrdeefdk
ddkgtwiirsemtkqpkgkimtskgmvlhmnrntrsttgyyvirkisednkseiddeekk
ypikmvnnkiiptqkindnklkneienfkffvqygsfknsddykegdieynpnapnysaq
yhlsnddynikqlrkrydiktkktprllmrgagdpkgssvgyknleftfvknneeniyft
dsinfnpskgksl
291.
vkhskklllcisfllitffiggcgfmnkddgketeikqnfnkmlnvyptknlenfydkeg
yrdeefdkddkgtwivhskmviepkgknmesrgmvlfinrntrtskgyfivneiekdrkg
rpinnkkkypvkmknnkiiptkpisndklkkeienfkffvqygnfkdiknykdgdisynp
nvpsysakyqlsnneynvqqlrkrydiptkkvpklllkgdgdlkgssvgsknleftfien
keeniyftdsvlfspsednes
292.
mrylkkvtiyisllilvsgcgngketeikqnfnkmldmyptknledfydkegyrdeefdk
kdkgtwivgstmtiepkgkymesrgmflyinrntrttkgyyyvrkttddskgrlkddekr
ypvkmehnkiiptkpipndklkkeienfkffvqygdfknlkdykdgdisynpnvpsysak
yqlsnndynvkqlrkrydiptnqapklllkgdgdlkgssigsksleftfienkeeniffs
dgvqftpsedses
293.
mkhsskiivfvsfliltifiggcgfinkedskeaeikqnfnktlsmyptknledfydkeg
yrdeefdkddkgtwiinskmivepkgeemeargmvlrinrntrtakgnfiikritennkg
ipdvkdkkypvkmehnkiiptkqikdkklkkeienfkffvqygnfknlkdykdgeisynp
nvpsysaqyqlnnydnnvkqlrkrydiptnqapklllkgtgdlkgssvgykhleftfven
kkeniyftdsinfnpsrgn
294.
mrylkkvtiyislliltifiggcgfinkedsketeikqnfnkmlnvyptknledfydkeg
frdeefdkgdkgtwiirsemtkqpkgkimtsrgmvlyinrntrtakgyflideikddnsg
rpienekkypvkmnhnkifptkpisddklkkeienfkffvqygdfknlkdykdgeisynp
nvpsysaqyqlnnndnnvkqlrkrydiptnqapklllkgdgdlkgssvgsknleftfven
keenifftdavqftpseddes
295.
mktykpyrhqlrrslfastifpvfmvmiiglisfyaiyiwvehrtihqhtyqtqtelqri
dkhfhtfvtqqqkqwrhvdlshptditkmkrqllkqvhqqpailyydlkgssqsftnnye
qldttkmyliskyridfkddtyilkiymsstpllknikknsgqsalivdsydtvlytndd
rfsigqkyqppqfgfmneslklnshhahliiykdihetiedgiallvvmgvvlillvifg
yisadrmakrqsedieaivrkiddaknrhlgsyeplkkhseleeinnyiydlfesneqli
qsieqterrlrdiqlkeierqfqphflfntmqtiqyliplspkvaqtviqqlsqmlrysl
rtashtvklaeelsyiqqyvaiqnirfddmiqlyidapedvqhqtigkmmlqplvenaik
hgrgseplkitirirltkrklhilvhdngigmspshlervrqslhhdvfdtthlglnhlh
nraiiqygtyarlhifsrshqgtlmcyqiplv
296.
vddvtkygpvdgdpitsteeipfdkkrefdpnlapgtekvvqkgepgtktittpttknpl
tgekvgegeptekitkqpvdeivhyggeeiktghkdefdpnapkgsqttqpgkpgvknpd
tgevvtppvddvtkygpvdgdpitsteeipfdkkrefdpnlapgtekvvqkgepgtktit
tpttknpltgekvgegeptekitkqpvdeivhyggeeikpghkdefdpnapkgsqedvpg
kpgvknpdtgevvtppvddvtkygpvdgdxitsteeipfdkkrefdpnlapgtekvvqkg
epgtktittpttknpltgekvgegeptekitkqpvdeiteyggeeikpghkdefdpnapk
gsqedvpgkpgvknpdtgevvtppvddvtkygpvdgdpitsteeipfdkkrefdpnlapg
tekvvqkgepgtktittpttknpltgekvgegeptekitkqpvdeivhyggeeiktghkd
efdpnapkgsqttqpgkpgvknpdtgevvtppvddvtkygpvdgdpitsteeipfdkkre
fdpnlapgtekvvqkgepgtktittpttknpltgekvgegeptekitkqpvdeivhygge
eikpghkdefdpnapkgsqedvpgkpgvknpdtgevvtppvddvtkygpvdgdsitstee
ipfdkkrefdpnlapgtekvvqkgepgtktittpttknpltgekvgegeptekitkqpvd
eivhyggeqipqghkdefdpnapvdsktevpgkpgvknpdtgevvtppvddvtkygpvdg
dsitsteeipfdkkrefdpnlapgtekvvqkgepgtktittpttknpltgekvgegkste
kvtkqpvdeiveygptkaepgkpaepgkpaepgkpaepgtpaepgkpaepgtpaepgkpa
epgkpaepgkpaepgkpaepgtpaepgtpaepgkpaepgtpaepgkpaepgtpaepgkpa
esgkpvepgtpaqsgapeqpnrsmhstdnknqlpdtgenrqanegtlvgsllaivgslfi
fgrrkkgnek
297.
atgaataaacagatttttgtcttatattttaatattttcttgatttttttaggtatcggt
ttagtaataccagtcttgcctgtttatttaaaagatttgggattaactggtagtgattta
ggattactagttgctgcttttgcgttatctcaaatgattatatcgccgtttggtggtacg
ctagctgacaaattagggaagaaattaattatatgtataggattaattttgttttcagtg
tcagaatttatgtttgcagttggccacaatttttcggtattgatgttatcgagagtgatt
ggtggtatgagtgctggtatggtaatgcctggtgtgacaggtttaatagctgacatttca
ccaagccatcaaaaagcaaaaaactttggctacatgtcagcgattatcaattctggattc
attttaggaccagggattggtggatttatggcagaagtttcacatcgtatgccattttac
tttgcaggagcattaggtattctagcatttataatgtcaattgtattgattcacgatccg
aaaaagtctacgacaagtggtttccaaaagttagagccacaattgctaacgaaaattaac
tggaaagtgtttattacaccagttattttaacacttgtattatcgtttggtttatctgca
tttgaaacattgtattcactatacacagctgacaaggtaaattattcacctaaagatatt
tcgattgctattacgggtggcggtatatttggggcacttttccaaatctatttcttcgat
aaatttatgaagtatttctcagagttaacatttatagcttggtcattattatattcagtt
gttgtcttaatattattagtttttgctaatgactattggtcaataatgttaatcagtttt
gttgtcttcataggttttgatatgatacgaccagccattacaaattatttttctaatatt
gctggagaaaggcaaggctttgcaggcggattgaactcgacattcactagtatgggtaat
ttcataggtcctttaatcgcaggtgcgttatttgatgtacacattgaagcaccaatttat
atggctataggtgtttcattagcaggtgttgttattgttttaattgaaaagcaacataga
gcaaaattgaaagaacaaaatatg
298.
atgctattttatttatttcattttacaatcagctttatatcaacagtacttttctctatc
attttcaatgcacccaaacgcctcttagtagcatgtggatttgtgggtgccattgcatgg
acgatttaccaattaacggtagatttagagtttggaaaagttggcgcttcatttttggga
agcttaattttaggcttaatgagtcatactatgagtcgcagatataaacgaccggtaatt
atattcatagtgccaggcattataccattagtacctggtggtgcagcttatcaagcgact
cgttttttagtatcaaatgattatacaagtgctgtaaatacatttttagaagttacactg
atttcaggtgcgattgctttcggtatattagtttctgaaattctatattacctatacaca
cgtatcaaacaactgtatggtaaaatcaaaggtaagacatataaaaaatcttacaacatg
aataatagagtt
299.
atgataaatgcagtagtaatagcagtaattttaatgattatgctatgtttatgtcgatta
aacgtagttataagcttatttatcagtgcgctagttggtggcttaatttcaggcatgagc
attgaaaaagttataaatgtatttgggaaaaatatagtcgatggtgctgaggtagcatta
agctatgctttattaggtggatttgcagcattaatttcatacagtggtatcacagactat
ttagtaggaaaaattataaatgcaattcacgctgaaaatagtcgatggtcaagagttaaa
gtcaaagtgacaataatcattgcattattagctatgagtatcatgagtcaaaacttaatt
cctgtacatattgcattcattccaattgtcatcccaccattgttaagtctgtttaatgac
ttaaaaatagatagacgtttaatcggtttgattatcggttttggtttatgtttcccgtat
gtgttattaccatatggattcggtcaaattttccagcaaattattcaaagtggctttgca
aaggcaaatcacccaattgagtttaatatgatttggaaagcaatgcttattccttcaatg
gggtatattgttggcttacttatcggtttatatgtatatcgtaaaccacgtgaatatgaa
acacgtaaaatttcagatagtgacaatgttacagagttaaaaccatatatcttaatagta
acaattgtagcaatactagctacatttttagtacaaacatttacagattcaatgattttt
ggtgcactggcaggggtactcgtattctttatttcacgtgcatataattggtatgaatta
gatgctaagtttgttgaaggtattaaaattatggcttatattggtgtagttattttaaca
gcaaatggatttgctggtgtaatgaatgctactggtgatatagatgaattagttaaaact
ttaacaagtattactggtgataataaattatttagcattatcatgatgtatgtgataggt
ttaattgtcactttaggtattggatcatcatttgcaacaattcctattatcgcatcatta
ttcattccttttggagcgtcaattggactagatacaatggcattaatcgcattgattgga
acagcgagtgcattaggtgactcaggttcgcctgcaagtgattcaacattaggaccaact
gcgggattaaatgttgatggccaacatgatcatatacgtgatacatgtgtaccaaacttc
ttgttttataatattcctttaatgattttcggtactattgctgctatggtacta
300.
atgaatcataatgttattatcgttattgcattaatcatagttgtcatttctatgttagct
atgctcattcgcgttgtgctaggcccatcacttgccgatcgtgttgtcgcattagatgcg
attggtcttcaattaatggcagttatagcattattcagtattttattaaatattaaatac
atgattgtcgttattatgatgattggtatattagcttttttaggtactgcagtattctct
aaatttatggacaaaggtaaggtgattgaacatgatcaaaatcatactgat
301.
gtgaataggaatatcgttaaactagttgtgttcatgctaattttagttgtagcagtagcg
ggttgtggtcaaaaagatactgaagagaaaactgaaatgacgacaataaaagatgaatta
ggaactgaaaaaattaagaaaaatcctaaacgtgttgttgtattagaatatagttttgct
gattatttagcagcattagatatgaaacctgttggtattgcagatgatggcagcactaaa
aatataacaaagtcagtaagagataagattggggcatatgaatcggttggatctagaccg
caaccgaatatggaagtgataagtaaattaaaaccggatttgatcattgcagatgttagc
agacataagaaaatcaaatcagaattgagcaaaattgctccgacaatcatgttagttagc
ggtacgggagattataatgcaaatattgaagcatttaaaacagtcgctaaagcagtaggc
aaagagaaagaaggcgagaagcgtctggaaaagcatgataaaatattagcggagattaga
aagaaaattgaacagagtacgttaaaatctgcatttgcattcggtatctcaagagcaggt
atgtttattaataatgaagatacatttatgggacaattcttaattaaaatgggtattcaa
cctgaagtcacaaaagacaaaactacgcatgttggtgaacgcaagggtggtccttatata
tatttaaataatgaagaacttgccaatatcaatccaaaagttatgattttagccactgac
ggaaaaacggacaaaaatagaacgaaattcattgatcctgcagtttggaaatcattaaaa
gctgtgaaagataacaaagtttatgacgttgaccgaaataagtggttgaaatcaaggggg
attatcgcaagtgaaagtatggcagaagatttagaaaaaattgcagaaaaagcaaaa
302.
atgactggagaacaatttactcaaattaaacgtccagtaagtagattaactgaaaaagtt
ctaggttggttatgttgggtgatgttattagtgcttactgtcattacgatgtttatagca
cttgtttcattcagtaataacacatcgattgctaatcttgaaaatacattaaacaataat
gcatttatccagcaattattagctggaaatggctataatacaacacaatttgtaatatgg
ttacaaaatggtatatgggctattatcgtttactttattgtttgtttgttgatttcattt
ttagctctcatatctatgaatataagaatcttgtcaggtttcttattcttaatatcagca
attgtaacgattcctttagttttacttatcgttactttaatcattccgatattattcttt
attattgcgatgatgctatttataagaaaagataaagttgaaatggttgcgccacaatat
tatgaagagtataacggaccgatttatgattatcgtgaacctgtgtatgagcgcccccaa
ccgaaagatgattattatgatgtgcctaaatatgaaaaagaattggataaatcaaatact
gtatatgatcaagaacaggaaagagataaatatgatcaatttcctaaacgtgcagttgaa
agtgaatataatcatgatgagcgcactgaggaagaaccatcagtattatccagacaggct
aaatacaaacaaaaaagtactgaagaactaggtattgaagatgatggttattatgcagaa
cctgaagttgatccaaaagaattgaaagcacaacaaaagcgagaaaaagctgaaattaaa
gctaagaaaaaagaaaaacgtaaagcttataaccaacgaatgaaagaacgtaggaaaaat
caacctagcgcagttagtcaacgtcgaatgaattttgaagagcgacgtcaaatttacaac
aatgatatttctgaagaacgcaattcaagtgaagttaaggacaaaaaagagcaagaa
303.
gtggaaaatacaattaatgaaagtgaaaagaaaaaacgatttaaattaaaaatgccaggt
gcatttatgattttattcattttaacggttgttgcagttatagcaacatgggttattcct
gctggtgcatattctaaactttcttacgaaccttcatcccaagaactaaagatagttaac
cctcataaccaagtgaaaaaggttccgggtacgcaacaggaactagacaaaatgggggtt
aaaattaagattgaacaatttaaatcaggtgcaattaataagccggtatcaattccgaat
acttatgaaagattaaagcaacatccagctggaccagaacaaataacaagtagcatggtt
gaaggtacgatagaagcggtcgatatcatggtattcattcttgtactagggggacttatt
ggcgtagttcaagccagtggttcttttgaatcgggattgttagctttaacgaagaaaaca
aaagggcatgaatttatgctaattgtgtttgtatcaatactaatgattatcggcgggaca
ttatgtggtattgaagaagaagctgtagcattttatccgattttagtccctatatttata
gcgttaggatacgattctatcgtttcagttggtgccatattccttgccagctctgtcggt
agtacattttcaactattaacccgttctcggttgtaattgcctctaatgccgctggtaca
acttttacggatggcttgtattggagaataggtgcttgtattgtcggtgcgatttttgtt
attagttatttatattggtactgtaaaaaaattaaaaacgatcctaaagcgtcatattct
tatgaagacaaagatgcttttgaacagcaatggtctgtattaaaagatgacgatagtgcc
cattttactttgcgtaagaagataatccttacattatttgtactaccatttccaattatg
gtatggggagttatgacgcaaggttggtggttcccagttatggcttcagcatttttaata
tttacaattataataatgtttattgctgggacaggtaaatctggattgggagaaaaagga
actgtagatgcatttgtcaatggtgcatcaagtttagtaggtgtatctttaattattggt
ttagctcgaggtattaatttagtgttgaatgaaggtatgatttcagatacaatcttacac
ttttcatcatctttagttcaacatatgagtggaccattatttatcatcgtattactattt
attttcttctgtttaggttttatcgtgccatcatcttctggcttagcggtattatcaatg
cctatctttgcaccactagctgatacagtaggtataccaagattcgtcatcgttacgaca
tatcaatttggtcaatatgcgatgttattcttagcgccgactggacttgttatggccaca
ctacaaatgttaaacatgcgatattcacattggttccgatttgtatggccggtagttgct
tttgtattgattttcggtggcggagtactaattacgcaagtactaatttattca
304.
atgagcttttttaaacgcttaaaagataagtttgcaacaaataaagaaaatgaagaagtt
aaatccttaacagaagaacaaggtcaagacaaattagaagatacacattctgaaggttca
acgcaggacgcaaatgatttagcagaaaatgctgaagtgaaaaagaagccacgcaagttg
agtgaagcggattttgatgacgatggcttaatatcaattgaagattttgaagaaattgaa
gctcaaaaaatgggtgctaaatttaaagcaggactcgaaaaatctcgtcaaaatttccaa
gaacaattaaataatttgatagcgagatatcgtaaagtagatgaagacttttttgaagct
ttagaagaaatgttaatcactgcagacgtcggttttaatacagtgatgacgttaactgaa
gaattacgtatggaagcacaacgacgtaatattcaagatactgaagatttgcgtgaagtc
attgttgaaaaaatcgtagagatttaccatcaagaagatgataattcagaagctatgaac
ttagaagatggtcgtttaaatgtcattttaatggttggtgtgaatggtgttggtaaaaca
acaacaattggaaaattagcttaccgatataaaatggaaggtaaaaaagtaatgttagct
gcgggcgatacttttagagcgggtgctattgatcaattgaaagtttggggcgaacgtgtt
ggtgtagacgtaattagccaaagtgaaggttctgatccagctgctgttatgtatgatgcg
attaatgccgctaaaaacaaaggtgttgatattttaatctgtgataccgctggacgttta
caaaataaaacaaatctaatgcaagaattagaaaaagttaagcgtgtaattaatcgagca
gtgccagatgcgcctcatgaagcattactatgtttagatgctacaactggtcagaatgcg
ttgtcacaagctagaaactttaaagaagtaacaaatgttacaggtattgtattaacgaaa
ttagatggtacagccaaaggtggtatcgtattagccattcgtaatgaattgcacatccca
gttaaatatgtaggtttaggtgagcaattagatgacttacaaccatttaaccctgaaagt
tatgtctacggcttattcgctgatatgattgaacaaaatgaagaaataacaacagttgaa
aatgatcaaattgtaacagaagaaaaggacgataatcatgggtcaaaa
305.
gtgttaaaaaagtggctaaattcaaacgtcaaacaattctttgttataactttcattagt
gtaatattaacgcttattttattttctactcatatctatgattatattgtgaatggtact
gtttttagcggggctggagatggattccgtcaaatgatgccatttcaaatgtatttgtat
gaacatctacgtagtttttctagtttatatgatgcatcgtttggattaggtggcgattat
atgaaaggactatcatattattattcgctgtcacctttaatgtggctaaattttctattc
attaaaataggagaaacggttggtatatttaatccgacgacaatacatttttggccgaca
aaccaacttattatggctatgatacgagctatcataacatttgtcgtgaccttctactta
tttaaaatattacactttaaacgctcagcaaatatgatcgctacgattttatacggcatg
tcaactgtcgttatatactttaattttacttggtcattttatggaaatttattatattta
ttgccattatcgattcttggtttggaaagatattttcaacaacgcaaaatcggtattttc
attgttgcgatagccttaacactatttagcaatttttatttcagttattatcaagctatt
attataggttgctactatttatatcgactcattttcacttacaaatatgacattgtctct
agaacacaaaaattaatttgcgtcatatctgctacagttttgagtgtgttatcaagtgta
tttggtttattcactggcatttctgcgtttttggaaaatgacagaaagcaaaatcccaat
gttgatataccgtttttgacaccacttgattatcattattttttctttagcgatggattt
tatattacgatttcaattcttactatcgttgcattattgtcattcaaactgtatcgtttt
tacttttatagacttttcgcaatagtaacatggatattatttataggttcattatcacag
tatttcgacagtgcttttaatggtttttcatttccagaaaggcgttgggtgtatatctta
gcactatcatcaagtgctctttgcggattgtttattcaacatttatcaacattaaatatg
aaatattatttaatcagaacaatacccgtatgcatcatcgcaatactttatgtattacta
tcaccgacacacccacttgcacttatagtaggtattatcctgctaatagtgcttgccgtt
attttaaaatttagtttatggcgttataaaaaattaaccgttgcaatattagtattaatc
gttatgattcaacaaatcgtcattttagataacaacaaaaacatggcaatcaaaccttat
caacaatcattatcaacgttgaaacaacatgattaccatagtaactatgtaaaccagctt
ataaaaaagataaatcaaaatgcaacaggctcatttaatcgcattgattatatgtcagac
tatgcattaaattcaccatttatatatcattataatggcatttcattatattctagtatt
tttaatggagacattttaaaatattatgacaagacactccaaattaatatgccaatcgat
aaaaacagcacttatagattacttggcaatcgtcaaaatttactatcactttggaatgtt
aatgatcgaattagagtgaatcatgatgacaacttaccatatggatttaaaattaagtct
gaacacaaagacaataaagttcgttggattcattctaaaaataccatccattatccaagt
gcacatattacaaataaggtcttttccaataaagaattaaaatctccattagataaagaa
caagcaatgttgcaagggattgtttctaacaatattaaagatgttaatacacattttaaa
gccaataaaaatttactatcagattcaacaattaaattaaatagtgcagcctggcaatct
cctacaaaacatttattacaagttaaacaaaataatggtggtctaactgtacagttgcca
aaatcagtttctaatcaatttaaagatttgtattttgaaatggatttagaattactttcg
ccggataaagctcatgatgttaaagtgaatgaatatacacaagaaagaaataaactcact
tataaatatcgacgcgttgtaacacccgtaacgatacgcattaaagctccagatagaatt
agattatcattgcctaaaggtaagtatcgagtaaatttaaaagggatatacggcgaagat
tataccacgcttaaagacgcttcaaattcattagaagctgtcaaagttagtaagacaaag
catggttatactattactaaaaataaaaattcatctgggtatattgttttgccaacagca
tataatcaaggtatgaaagcgacatcaggtgatcaaagtcttaaagttgaacaagtaaat
ggtgttatgaccggcattaaagcacctaaaaatataacaaagattcaattgagctatacc
ccaccatactattatttacttataacaattactatatttggcattatatgtagtattatt
ttcacgagatgggcaagacaaaaa
306.
gtgcgtcaattggcacaagcaaaaaagaaatcgacagctaagaaaaaaacaacatcaaaa
aaaagaacaaattcgaggaaaaagaagaatgataatccgatacgttatgtcatagctatt
ttagtagttgtattaatggtgttgggtgttttccaattaggaataataggtcgtctaatt
gacagcttctttaattatttatttgggtacagtagatatttaacatatattttagtactc
ttagcaactggttttattacatactctaaacgtattcctaaaactagacgaacggctggt
tcgattgtattgcaaattgcattgctatttgtatcacagttagtttttcattttaatagt
ggtatcaaagctgaaagagaacctgtactttcttatgtgtatcagtcataccaacacagt
catttcccaaattttggtggcggtgtattaggcttttatttattagagttaagcgtacct
ttaatttcattatttggtgtatgtattattactattttattattatgctcaagtgttatt
ttattaacaaaccatcaacatcgtgaagttgcaaaagttgcactggaaaatataaaagct
tggtttggttcatttaatgaaaaaatgtcggaaagaaaccaagaaaaacaattgaagcgt
gaagaaaaagcaagacttaaagaagaacaaaaggcacgtcaaaatgaacagccacaaata
aaagatgtgagtgattttacggaagtgcctcaagaaagagatattccaatttatgggcat
actgaaaatgaaagtaaaagccagagtcaaccaagtcgaaaaaaacgagtgtttgatgca
gagaatagttcgaataacatcgtaaatcatcatcaagcagatcagcaagaacaattaaca
gaacaaactcataacagtgttgaaagtgaaaacactattgaagaagctggtgaagttacg
aatgtatcgtatgttgttccaccgttaactttacttaatcaacctgcaaaacaaaaagca
acatctaaagctgaagtgcaacgtaaaggacaagtactagagaatacattaaaagatttt
ggggtaaatgcaaaagtgacacaaattaaaattggtcctgcagtaactcaatatgaaatt
caaccagctcaaggggttaaagtgagtaaaattgtaaacttgcataatgatattgcatta
gctttagcagcaaaagatgttagaatcgaagcgccaatacctggtcgttctgcagtaggt
attgaagtgccaaatgagaaaatttcattagtttcactaaaagaagttttagatgaaaaa
ttcccgtctaataataaactagaagttggattaggaagagatatatcaggtgatccaatt
actgttccactaaatgaaatgccacacttattggtggcaggatcgacgggtagtggtaaa
tctgtttgtataaatggtattattacaagtattttattaaatgctaagccgcatgaagtt
aaacttatgttaatcgatccgaaaatggttgaactaaatgtttataacggaattccacac
ttattaattccggttgttacaaatcctcataaagctgctcaagctttagaaaaaattgta
gctgagatggaaagacgttatgatttattccaacattcatcaactagaaacattaaaggt
tataacgaattaatccgtaagcaaaatcaagaattagatgagaagcaaccagaattacct
tatatcgttgttattgtagatgagcttgcagatttaatgatggtagctggtaaagaagtt
gaaaatgcgattcaacgtattacacaaatggcacgtgcagcaggtatacatttaattgta
gcgacacaaagaccttctgtggatgtaattacaggtatcattaaaaataatattccatct
agaatagcttttgctgtgagttctcaaacagattcaagaactattattggtactggcggc
gcagaaaagttacttggtaaaggtgacatgttatacgttggaaatggtgactcatcacaa
acacgtattcaaggggcgtttttaagtgaccaagaggtgcaagatgttgtaaattatgta
gtagaacaacaacaggcaaattatgtaaaagaaatggaaccagatgcaccagtggataaa
tcggaaatgaaaagtgaagatgctttatatgatgaagcgtatttgtttgttgttgaacaa
caaaaggcaagtacatcattgttacaacgccaatttagaattggttataatagagcatct
aggttgatggatgatttagaacgcaatcaggtaatcggtccacaaaaaggaagcaagcct
agacaagttttaatagatcttaataatgacgaggtg
307.
atggctgaaaaattacaaagggaactgagcaatcgccacatacaattaattgcaattggc
ggtgcaattggtacaggcttattcttaggtgctggtcaaacgattgcattaaccggccct
tcaattctattaacatacatcattataggatttatgttatttatgtttatgcgaggttta
ggagaaatcattatacagaatactgaatttaaatctttcgcagatgtaaccaatacatat
attgggccttttgcaggatttgttaccggatggacatactggttctgttggattattaca
ggtatggctgaagtaacggctgtggcaaaatatgttagcttttggttcccagaaattcca
aactggataagtgcactattttgtgtactgttattaatgtcattcaacctacttagcgca
agacttttcggagaattagaattttggttctctatcattaaaatagcgacaattattggt
ttaatagtagttggtttcgtcatgattctatttgcatttaaaactcaattcgggcatgcc
agtttcacaaatctatatgaacacggcatattcgctaaaggtgcttctggattctttatg
tctttccaaatggcactattctcatttgtaggaattgaaatgattggtgttacagctggg
gaaacaaaagatccagttaaaacaattccaaaagcaattaacagtgtacccattagaatt
ttaatattttacgttggggcgttagcggttatcatgtctattatcccttggcagcaagtt
gatcctgataacagtccattcgtaaaattattcgcattgatcggaattccgtttgctgcg
ggcttgattaattttgtagtattaaccgctgctgcttcatcatgtaacagtggtatattc
tcaaatagccgtatgcttttcggtttatcaagtcaacaacaagcacctccgaacttttct
aagacgaataaatatggcgttccacatgttgcaatctttgcttcatcagcattattactt
gtggcagcattactaaactatattttcccagatgcgacaaaagtatttacgtatgtgact
accatctctacagtgttatttttagttgtatggggtctgattatcattgcatatatcaat
tatagtcgtaaaaacccagatctacataaaaatgctacgtacaaactattaggtggcaaa
tatatgggctacttaatatttgtattcttcatttttgtgttcgggttattatttattaat
gttgatacaagacgtgcaatttattttattccgatttggtttatacttttagcatttatg
tacttaagatataaacgtatcgctgctaaatcaaataaa
308.
atgaatttgttaaagaaaaataaatatagtattaggaagtataaagtaggcatattctct
actttaatcggaacagttttattactttcaaacccaaatggtgcacaagccttaactacg
gataataatgtacaaagcgatactaatcaagcaacacctgtaaattcacaagataaagat
gttgctaataatagaggtttagcaaatagtgcgcagaatacacctaatcaatctgcaaca
accaatcaagcaacgaatcaagcattggttaatcataataatggtagtatagtaaatcaa
gctacgccaacatcagtgcaatcaagtacgccttcagcacaaaacaataatcatacagat
ggcaatacaacagcaactgagacagtgtcaaacgctaataataatgatgtagtgtcgaat
aataccgcattaaatgtaccaactaaaacaaatgaaaatggttcaggaggacatctaact
ttaaaggaaattcaagaagatgttcgtcattcttcaaataaaccagagctagttgcaatt
gctgaaccagcatctaatagaccgaaaaagagaagtagacgtgcggcaccggcagatcct
aatgcaactccagcagatccagcggctgcagcggtaggaaacggtggtgaaccagttgca
attacagcgccatatacgccaacaactgatcctaatgccaataatgcaggacaaaatgca
cctaacgaagtgctgtcatttgatgacaatggtattagaccaagtaccaaccgttctgtg
ccaacagtaaacgttgttaataacttgccgggcttcacactaatcaatggtggcaaagta
ggggtgtttagtcatgcaatggtaagaacgagcatgtttgattcaggagataataagaac
tatcaagcacaaggaaatgtaattgcattaggtcgtatacatggaactgatacgaatgac
catggcgattttaatggtatcgagaaagcattaacagtaaatccgaattctgaattaatc
tttgaatttaatacaatgactactaaaaacggtcaaggcgcaacaaatgttattatcaaa
aatgctgatactaatgatacgattgctgaaaagactgttgaaggcggtccaactttgcgt
ttatttaaagtacctgataatgtgagaaatctcaaaattcaatttgtacctaaaaatgac
gcaataacagatgcgcgtggcatttatcaactaaaagatggttacaaatactatagcttt
gttgactctatcggacttcattctgggtcacatgtttttgttgaaagacgaacaatggat
ccaacagcaacaaataataaagagtttactgtaacaacatcattaaagaataatggtaat
tctggtgcttctctagatacaaatgactttgtatatcaagttcaattacctgaaggtgtt
gaatatgtgaacaattcattgactaaagattttccaagtaacaattcaggcgttgatgtt
aatgatatgaatgttacatatgatgcagcaaatcgtgtgataacaattaaaagtactgga
ggaggtacagcaaactctccggcacgacttatgcctgataaaatactcgatttaagatat
aaattacgtgtaaataatgtgccgacaccaagaacagtaacatttaacgagacattaacg
tataaaacatatacacaagatttcattaattcagctgcagaaagtcatactgtaagtaca
aatccatatactatcgatatcatcatgaataaagatgcattacaagccgaagttgacaga
cgtattcaacaagctgattatacatttgcgtcattagatatctttaatggtctgaaacga
cgcgcacaaacgattttagatgaaaatcgtaacaatgtaccattaaataaaagagtttct
caagcatatattgattcattaactaatcaaatgcaacatacgttaattcgaagtgttgat
gctgaaaatgcagttaataaaaaagttgaccaaatggaagatttagttaatcaaaatgat
gaattgacagatgaagaaaaacaagcagcaatacaagttatcgaggaacataaaaatgaa
ataattggtaatattggtgaccaaacgactgatgatggcgttactagaatcaaagatcaa
ggtatacagaccttaagtggggatactgcaacaccggttgttaaaccaaatgctaaaaaa
gcaatacgtgataaagcaacgaaacaaagggaaattatcaatgcaacaccagatgttact
gaagacgagattcaagatgcactaaatcaattagctacggatgaaacagatgctattgat
aatgttacgaatgctactacaaatgctgacgttgaaacagctaaaaataatggcatcaat
actattggagcagttgttcctcaagtaactcataaaaaagctgcaagagatgcaattaac
caagcaacagcaacgaaaagacaacaaataaatagtaatagagaagcaactcaggaagag
aaaaatgcagcattgaacgaattaactcaagcaaccaaccatgctttagaacaaatcaat
caagcaacaacaaatgctgatgttgataacgccaaaggagatggtctaaatgccattaat
ccaattgctcctgtaactgttgttaagcaagctgcaagggatgccgtatcacatgatgca
caacaacatatcgcagagatcaatgctaatcctgatgcgactcaagaagaaagacaagca
gcaattgacaaagtgaatgctgctgtaactgcagcaaacacaaacattttaaacgctaat
accaatgctgatgttgaacaagtaaagacaaatgcgattcaaggaatacaagcaattaca
ccagctacaaaagtaaaaacagatgcaaaaaatgccatcgataaaagtgcggaaacgcaa
cataatacgatatttaataataatgatgcgacgctcgaagaacaacaagcagcacaacaa
ttacttgatcaagctgtagccacagcgaagcaaaatattaatgcagcagatacgaatcaa
gaagttgcacaagcaaaagatcagggcacacaaaatatagtagtgattcaaccggcaaca
caagttaaaacggatactcgcaatgttgtaaatgataaagcgcgagaggcgataacaaat
atcaatgctacaactggcgcgactcgagaagagaaacaagaagcgataaatcgtgtcaat
acacttaaaaatagagcattaactgatattggtgtgacgtctactactgcgatggtcaat
agtattagagacgatgcagtcaatcaaatcggcgcagttcaaccgcatgtaacgaagaaa
caaactgctacaggtgtattaaatgatttagcaactgctaaaaagcaagaaattaatcaa
aacacaaatgcaacaactgaagaaaagcaagtggctttaaatcaagtggatcaagagtta
gcaacggcaattaataatataaatcaagctgatacaaatgcggaagtagatcaagcgcaa
caattaggtacaaaagcaattaatgcgattcagccaaatattgttaaaaaacctgcagca
ttagcacaaatcaatcagcattataatgctaaattagctgaaatcaatgctacaccagat
gcaacgaatgatgagaaaaatgctgcgatcaatactttaaatcaagacagacaacaagct
attgaaagtattaaacaagctaacacaaatgcagaagtagaccaagctgcgacagtagca
gagaataatatcgatgctgttcaagttgatgtagtaaaaaaacaagcagcgcgagataaa
atcactgctgaagtggcgaagcgtattgaagcggttaaacaaacacctaatgcaactgac
gaagaaaagcaggctgctgttaatcaaatcaatcaacttaaagatcaagcaattaatcaa
attaatcaaaaccaaacaaatgatcaggtagacacaactacaaatcaagcggtaaatgct
atagataatgttgaagctgaagtagtaattaaaccaaaggcaattgcagatattgaaaaa
gctgttaaagaaaagcaacagcaaattgataatagtcttgattcaacagataatgagaaa
gaagttgcttcacaagcattagctaaagaaaaagaaaaagcacttgcagctattgaccaa
gctcaaacgaatagtcaggtgaatcaagcagcaacaaatggtgtatcagcgattaaaatt
attcaacctgaaacaaaagttaaaccagctgcacgtgaaaaaatcaatcaaaaagcgaat
gaattacgtgctaagattaatcaggataaagaagcaacagcagaagaaagacaagtagca
ctagataaaatcaatgaatttgtaaatcaagccatgacagatattacgaataatagaaca
aatcaacaagttgatgatacaacaagtcaagcgcttgatagcattgctttagtgacgcct
gaccatattgttagagcagctgctagagatgcagttaagcaacaatatgaagctaaaaag
cgcgaaattgagcaagcggaacatgcgactgatgaagaaaaacaagttgctttaaatcaa
ttagcgaataatgaaaaacgtgcattacaaaacatcgatcaagcaatagcgaataatgat
gtgaaacgtgttgaaacaaatggcattgctacactaaaaggtgtacaacctcatattgta
attaagcctgaagcacaacaagcaataaaagcaagtgcagaaaatcaagtagaatcaata
aaagatacaccacatgcaacagttgatgaattagatgaagcgaatcaattaattagcgac
acactcaaacaagcgcaacaagaaatagaaaatacaaatcaagatgctgctgttactgat
gttagaaatcaaacaatcaaggcaatagagcaaataaaacctaaagtaagacgtaaacga
gctgcgcttgatagcattgaagaaaataataaaaatcaactcgatgcaatccgaaatacg
ttggatactactcaagatgaaagagatgttgctattgatactttaaataaaattgtaaat
acaattaaaaatgacattgcacaaaacaaaacgaatgcagaagtggatcgaactgagact
gatggcaacgacaacatcaaagtgattttacctaaagttcaagttaaaccagcagcgcgt
caatctgttggtgtaaaagccgaagctcaaaatgcactaatcgatcaaagcgatttatca
actgaagaagaaagactagctgctaaacatttagtagaacaagcacttaatcaggctatt
gatcagatcaatcatgcagataagactgcccaagttaatcaagatagtataaatgctcaa
aatattatttcaaaaattaaaccagcgacaacagttaaagcaacagcattacaacaaatt
caaaatatcgctacaaataaaattaatttaattaaagcaaataacgaagcgacagatgaa
gaacaaaatattgcaatagcacaagttgaaaaagagttaattaaagctaaacaacaaatt
gctagtgcagtgactaatgcagatgtggcatatttattgcatgatgagaaaaacgaaatt
cgtgaaatcgaacctgttattaacagaaaggcgtctgctcgagaacaattgacaacatta
ttcaacgataaaaaacaagcaattgaagcgaatattcaagcaacggtagaagaaagaaat
agtatattagcacagttacaaaatatttatgacactgctattggacaaattgatcaagat
cgtagcaatgcacaagttgataaaacagcatcattaaatctacaaacaatacatgattta
gatgtacatcctattaaaaagccagatgctgaaaaaacgattaatgatgatcttgcacgc
gtcactgctttagtgcaaaattatcgaaaagtaagtaatcgtaataaggctgatgcatta
aaagctataactgctttaaaattacaaatggatgaagaattaaaaacagcacgcactaat
gctgatgttgatgcagttttaaaacgatttaatgttgcattaagcgatatagaagcagta
attactgaaaaagaaaatagcttactgcgaattgataacattgctcaacaaacatatgcg
aaattcaaagcgatcgcaacaccagaacaattagctaaagtaaaagtattaattgatcaa
tatgttgcagatggcaatagaatgattgatgaagatgcgacattaaatgacatcaaacaa
cacacgcaattcattgttgatgaaattttagcaattaaattaccagctgaagcgacgaaa
gtatcaccaaaagaaattcagccagctccaaaagtttgtacgcctattaaaaaagaagag
acacatgaatcgcgcaaagttgaaaaagaacttccaaatacaggttctgaaggaatggat
ttaccattgaaagaatttgcactgattacaggtgcggctttgttagctagaagacgtact
aaaaacgaaaaagaatca
309.
atgagtgttgaaatagaatcaattgaacatgaactagaagaatcaattgcatcattgcga
caagcaggcgtaagaattacacctcaaagacaagcaatattacgttatttaatttcttca
catactcatccaacagctgatgaaatttatcaagcactttcacctgattttccaaatata
agtgttgcgacaatatataataacttaagagtgtttaaagatattggaattgtaaaagaa
ttaacatatggagactcatcaagtcgattcgactttaatacacataatcattatcatatt
atatgtgaacaatgtggtaagattgttgattttcaatatccacagttaaatgaaattgaa
agattagctcagcatatgactgactttgacgtaacacatcatcgaatggaaatttatgga
gtttgtaaagaatgccaagataaa
310.
atgagtgaaaaacaacaaattctcgattatatagaaacaaataaatatagttatatcgaa
atcagtcatagaattcatgaacgtcctgaacttggtaatgaagaaatatttgcgtctcga
actttaatagatcgtttgaaagagcatgattttgaaattgaaaccgagattgctgggcat
gcaactgggtttatagcgacatatgattcaggacttgacgggccagctataggtttttta
gcagaatacgatgctttgccaggattgggtcatgcttgtggtcataatatcattggaact
gcaagtgttcttggtgcaattggtttgaagcaagtgattgaccaaattggtggtaaagta
gtcgttcttggatgtccagctgaagaaggtggggaaaatggtagcgctaaagcttcttat
gtcaaggctggtgtgattgatcaaatagacattgccttaatgattcatccgggaaatgaa
acttataaaacgattgatactttggcagtggatgttttagatgttaaattttacggaaaa
agtgctcatgcctctgaaaatgcagatgaagcgttaaatgcattagacgctatgattagt
tattttaatggtgtagcacaactacgacaacatattaaaaaagatcaacgtgtgcatggt
gtgattttagatggcgggaaagcagctaatattattccagactatacacatgctcgtttt
tatactagagcaatgacgcgtaaagaattggatatattaacagaaaaagtaaatcaaatc
gcacgtggagctgcgatacagactggttgtgattatgaatttggtcgaattcaaaacggt
gtgaatgaattcattaaaacgccgaaattagatgatttatttgctaaatatgctgaagaa
gttggtgaagcagttattgatgatgattttggttatggctctacggatacagggaacgta
agtcatgttgtgccaacaatacatcctcatattaaaataggatcacgtaatttagtagga
catacgcatagatttagagaagcggctgcgagtgtacatggtgatgaagcattaattaaa
ggcgctaaaataatggcgttgatggggttagagttaattacaaatcaagacgtttatcaa
gacattattgaagagcatgcgcatttgaaagggaatgggaag
311.
atgactacgaccttcattattagctacattattttagcgctcattattgttggggttatc
aatttatttttaataagatcaagaaaaaaaggcaaacgccaacaaaaggaacaacaattt
acgacacgtcaatcaaatcaatctaaatttaaagctagtgatttagacaaaacaactgat
caatcgacacaacgtatgacgcatgaagagttgcgtgttgacaatcaagatgatcatagc
caagttagtctaaatggttacacaaaggggtctgagaaagatcaagaagcattcactaat
aataaggatgaggaagcagttgctgctaaaaatcctgaatcagaagaatataaagtgaat
gaaaaaataaaaaaagaacataaaaactttatttttggtgaaggtgtttcacgcggtaaa
atattagcggcattattattcggtatgtttattgcgattttaaaccaaacattattaaat
gttgctttaccaaaaattaatacggaatttaatatttctgcgtcaacagggcaatggttg
atgacgggattcatgttagtaaacggtattttaataccaattacggcgtatctatttaat
aaatattcatatcgaaaattatttttagttgcgttagtactctttacaattggttcatta
atctgtgcgatttcaatgaatttcccaatcatgatggttggacgtgtattacaagccatt
ggtgcaggtgtactaatgccattaggttcaattgttattattacaatttatccacctgaa
aaacgtggtgctgccatgggtacaatgggtatcgcaatgattttagcacctgcaattggt
ccaacattatcaggttatattgtacaaaattaccattggaatgtgatgttttacggtatg
ttcattatcgggattatcgctattttaattggttttgtatggtttaagttatatcaatat
acaacaaaccctaaagctgatatcccaggtatcatttttagtacgattggttttggtgct
ttgttatatggtttctcagaagctggcaacaaaggttggggttcagtagagatagaaaca
atgtttgcgattggtattatctttattattctattcgttattagagaattaagaatgaaa
tcaccaatgttgaatttagaagtattgaaattcccaacatttacattaacaacaattatt
aatatggttgtaatgttaagtttatatggtggtatgattttattaccgatttatttacaa
aatttacgcggattctcagcattagattccggattgttattattacctggttctctaatt
atgggtctactaggaccatttgcaggtaaattgttagatactattggtttaaaaccatta
gctatctttggtattgctgtaatgacttatgcaacatgggaattaactaaattaaatatg
gatacaccatatatgacaatcatgggtatctatgtacttcgttcatttggtatggcattt
ataatgatgccaatggtaactgcagctattaatgcgttaccgggacgacttgcctctcat
ggtaatgctttcttaaatacgatgcgtcaattagcaggctctataggtacagcaatctta
gttactgtaatgacaacacaaactacacaacacttatcagcttttggggaagagttagat
aaaacgaatcctgttgtacaagatcatatgcgtgaattagcatcacaatatggcggacaa
gaaggcgcaatgaaagtgttactacaatttgtaaataaactagcaacggttgaaggtatt
aatgatgcatttatagttgcaacgatatttagcatcatcgccttaattttatgtttattt
ttacaaagtaataaaaaagcaaaagctacagctcaaaagttagatgcagataatagtatc
aatcatgaa
312.
atgattaaaaataaaatattaacagcaactttagcagttggtttaatagcccctttagcc
aatccatttatagaaatttctaaagcagaaaataagatagaagatatcggccaaggtgca
gaaatcatcaaaagaacacaagacattactagcaaacgattagctataactcaaaacatt
caatttgattttgtaaaagataaaaaatataacaaagatgccctagttgttaagatgcaa
ggcttcattagctctagaacaacatattcagacttaaaaaaatatccatatattaaaaga
atgatatggccatttcaatataatatcagtttgaaaacgaaagactctaatgttgattta
attaattatcttcctaaaaataaaattgattcagcagatgttagtcagaaattaggctat
aatatcggcggaaacttccaatcagcgccatcaatcggaggcagtggctcattcaactac
tctaaaacaattagttataatcaaaaaaactatgttactgaagtagaaagtcagaactct
aaaggtgttaaatggggagtgaaagcaaattcattcgttacaccgaatggtcaagtatct
gcatatgatcaatacttatttgcacaagacccaactggtccagcagcacgagactatttc
gtcccagataatcaactacctcctttaattcaaagtggctttaatccatcatttattaca
acattgtcacacgaaagaggtaaaggtgataaaagcgagtttgaaatcacttacggcaga
aacatggatgctacatatgcttacgtgacaagacatcgtttagccgttgatagaaaacat
gatgcttttaaaaaccgaaacgttacagttaaatatgaagtgaactggaaaacacatgaa
gtaaaaattaaaagcatcacacctaag
313.
atgcaatcaacgaaaaccaaaacgaagcatttttcatttttattgctaattacgttaggc
gtcatgaccgcttttggcccactaactatagatatgtacgtaccatcattacctaaagtg
caaggtgattttggttctactacatcagaaattcaattaacattatcattcacaatgatt
ggtcttgcactaggccaatttatctttggacctttatccgatgcttttggtcgcaaacgg
attgctgtatccattttgatcattttcattttggtatcaggtttgtctatgtttgttgat
caattgccattattcttaactttacgatttattcaaggtttaactggtggtggcgtcatc
gtgattgcaaaagcctctgctggtgataaatttagtggcaacgcactcgctaaattttta
gcatctttaatggtagttaatggcatcatcactattcttgcaccattagccggtggatta
gctttatccgtagcaacatggcgttctattttcacaattttaactattgtggcactcatc
attttaattggcgtcgcttctcaattacctaaaacatctaaagatgaattaaagcaggtg
aattttagtagcgtcattaaagattttggaagtcttttgaaaaaaccagcatttattatt
ccaatgctattacaaggtttaacttatgtaatgctatttagttattcatctgcatcgcca
tttattactcaaaaattgtataatatgacaccccaacaatttagtatcatgtttgctgtt
aacggtgtaggtttaatcattgtcagtcaagtcgttgctttattagtagaaaaattacat
cgccacatattattaatcattttaactattatacaagtggtaggtgttgctttaattatc
ctgacacttacattccatttaccactttgggtcttactcatcgcattcttcttaaatgtg
tgtcctgtgacgtcaattggaccgcttggtttcacaatggctatggaagaacgaacaggt
ggcagtggtaacgcatcaagtttacttggcttattccaatttatcttaggtggcgctgtt
gcaccattagttggcttaaaaggcgaatttaatacatcaccatatatgattattatcttc
attacagccattctattagtcagtctacaaatcatttactttaaaatgattaaaaagcaa
catgtcgca
314.
atgatgtatggatatccagagaaatggttggaaggtatgacaactggagaaggtatcgcg
gcagaattacgcttaggcattgtgaatggtcacatagctgaaggtacgttactcactgaa
aatcaaatggcaaagcaatttaatgtgagtcgttcgccaattcgagatgcatttaaatta
ttgcaacaaaatcaactcatccaattagaaagaatgggtgcacatgtgttgccgtttggg
gaacaagaaaagaaagaaatgtatgatttgcgactgatgttagagtcatttgcattttca
agagttaaaaatcaagagcgactacctatcgtaaaagaaatgaagaaacaacttgaaatg
atgaaagtggcagtaaaatttgaggatgcagaatcatttacgaagcatgactttgaattt
catgaaacattaatcaaagcatctaatcatcaatatttaaactcattttggagtcattta
aaaccagtaatgatggcactcgttttaacatccatgcgacaacgtatgcaacagaacccg
caagattttgaacgcatacatcataatcatcaagtgtttattgatgcagtggaacaatac
gacagtcaaattttgaaagaagcgtttcatttaaatttcgacgatgttggtaaagatatt
gaaggattttggttgaat
315.
atgggaagttttttcaataaaatagcacgaaaagaggatccggctatctatcaaaataaa
gatggtcatttaaagcgtacacttcgggtgcgtgatttcttagctttaggtgtaggaaca
attgtatcgacatctatctttacgctacctggcattgttgctgcagaacatgcaggaccg
gccgttgcgttatcattcttactcgctgctattgttgctggtttagttgcatttacttat
gcagaaatggctgccgctatgccatttgcaggttcagcctattcttgggtcaatgtatta
tttggtgaattttttggatgggttgccggttgggctctattagctgaatattttatcgcc
gtagcctttgttgcatcaggattctcagcgaatttacgcggacttgtgaaaccaattggc
atcgaattacctgcagcattatcaaatccatttggtacaaatggcggttttatcgatatt
attgctgctatcgttattttattaactgcattattactatcacgtggtatgtcggaagca
gctcgtatggaaaatattttagttattttaaaagtattagctattattttatttgtcatc
gtaggtttaacagcaataaatgttagtaactatgtgccatttattccagaacacaaagta
actgctacaggtgactttggtggatggcaaggcatatatgctggtgtttcaatgattttc
ttagcgtatatcggtttcgattctatcgcagcaaactcagcagaagcacttgatcctcaa
aagacaatgcctagaggtattcttggttctttaagcgttgctatcgtattatttattgct
gtagcacttgtgttagttggtatgttccattactcacaatacgcaaacaatgctgaacct
gttggttgggctttacgtcaaagtggtcatggtgttgtagcagctattgttcaagctatc
tctgttatcggtatgtttacagcattaattggtatgatgttagcaggctcacgtttactt
tattcatttggacgtgacggcttattaccttcatggttaagccacttaaacgacaaacat
ttacctaatcgcgcactagttatacttactattattggtgttttaattggttctatgttc
ccattcgcatttttagcacaattaatttcagcaggtacacttgttgcatttatgttcgtt
tcattagcaatgtatcgtttgagaaagcgtgaaggtaaagatctaccaattcctgcattt
aaattacctttatatcctgtgttaccagcaattacatttgttttagtattgctagtattc
tggggattaggattcgaagcgaaattatacactttaatttggtttattgttggtatcatc
ctatatttaagttatggacttagacattctaagaaaaatgacgtagctgaataccaccca
ccaaaa
316.
atgaatagtgataatatgtggttaacagtaatggggctcattattattatttcaattgta
ggtttactcattgccaaaaagataaatccagttgtaggtatgacaatcataccttgctta
ggggcaatgattttaggatatagtgtgacagatttggttggattttttgctaaagggtta
gatcaagtcatcaacgttgttattatgtttatctttgccattattttctttggcatcatg
aacgatagtggtttattcaagccgcttgtcaaacgcttaatattaatgacacgaggcaat
gtcgtcattgtctgtgcaatgacagctttaattggcacaatagcccaattagatggggcc
ggtgcggtaacatttttgctttctattcctgcattattacctttatataaagcgttaaat
atgaataaatatttattgattttactattagcattaagcgcggcgattatgaacatggta
ccttggggaggtccaatggctcgtgtagctgcagtgttaaaagccaaaagtgtcaatgaa
ttatggtatggattaatacctattcaaataataggtttcattcttgttatgttgtttgcg
gtatatcttggatttaaagaacagaaacgtatcaaaaaagcaatagagagaaatgaatta
ccgcaaacacaagatatagatgtacataaattagttgaagtatatgaacgagatcaagat
gtaaggtttcctgtaaaaggacgtgcaagaacaaaatcatggataaaatgggtgaataca
gctttaactttagctgttattctatcgatgttaataaatattgcgccacctgaatttgca
ttcatgataggtgtttcgttggcacttgttattaattttaaatcagtggatgaacaaatg
gaacgattaagagcgcatgcgccgaatgcattaatgatggctgcagtgattattgcagca
ggtatgtttttaggtgtactaaatgaaaccggtatgcttaaagcgattgcgaccaattta
atcaaagtgattcctgcagaagtaggaccatacttgcatattattgtaggtttacttggc
gtaccattagatttactaactagcacagacgcttattattttgctgtgttaccgattgtc
gaacaaacagcagggcaatttggtgtaccgtctgtatcaacagcttattcaatggtcata
gggaatattataggtacatttgtcagcccattttcaccagccttatggttggcaattggt
ttagcagaggcaaacatgggcacgtatattaagtatgcattcttttggatttggggattc
gctatcgttatgttagtaattgcaatgttgatgggcattgtgacgatt
317.
atggaaaacacggttaaatatcgtaagtttatactccctatcgttgtaggtctccttatt
tgggcacttacaccttttaaaccggatgctgtggatccaacagcatggtatatgttcgca
atattcgtcgcgacaatcattgcttgtattacacaaccgatgccaattggggccgtctct
ataattggatttacaatcatggtactcgttggcattgttgacatgaaaacggctgtcgct
ggttttggtaataatagcatttggttaattgctatggcatttttcatttcgagaggattt
gtgaaaacaggtcttggtagacgtatcgcacttcatttcgtcaaattatttggtaaaaaa
acattaggattagcatattctatcgtcggtgtagatttaattctagcgcctgctacacca
agtaataccgcgcgtgctggtggaatcatgttcccaattatcaaatcactttctgaatca
tttggttcgaaaccgaaagacggatcagcacgcaaaatgggtgcatttcttgttttcaca
gaattccaaggtaatttaattactgcggctatgtttttaactgcaatggccggtaacccc
cttgcacaaaatttagcatctagcacatctaatgttcacattacatggatgaattggttt
ctagctgctttagttcctggacttgtttccttaattgttgtaccttttattatttataaa
atttatccaccaactgttaaagaaacaccaaatgctaagagttgggctgaaaatgaatta
gcgactatgggtaaaatcgctttagctgaaaaatttatgattggtatttttgtcgttgcg
ttaacactatggattgtcggaagtttcattcatattgatgcaactttaacggcctttatt
gcgctagcattgttattattgacaggcgtcttaacatggcaagacattttaaacgaaaca
ggtgcttggaacacattagtatggttctcagtattagtgttaatggccgaccaattaaac
aagcttggatttattccttggttaagtaaatccattgctacaagtcttggtggcttaagc
tggcctatagtcctggtcattttaatattgttctacttctattcacattacttatttgca
agttctacagcacatatcagtgcgatgtatgcagcattactaggcgttgccatcgcagcc
ggtgcaccaccattattcagtgcattaatgttaggtttcttcggtaacctattagcttca
acaacacactatagtagtggtccagcgccgattctattctcttcaggttacgtgactcaa
aaacgttggtggacaatgaacttaatattaggtttcgtctactttattatctggattggt
ttaggatcactttggatgaaagtaattggtatattt
318.
atgaataaagtaattaaaatgcttgttgttacgcttgctttcctacttgttttagcagga
tgtagtgggaattcaaataaacaatcatctgataacaaagataaggaaacaacttcaatt
aaacatgcaatgggtacaactgaaattaaagggaaaccaaagcgtgttgttacgctatat
caaggtgccactgacgtcgctgtatctttaggtgttaaacctgtaggtgctgtagaatca
tggacacaaaaaccgaaattcgaatacataaaaaatgatttaaaagatactaagattgta
ggtcaagaacctgcacctaacttagaggaaatctctaaattaaaaccggacttaattgtc
gcgtcaaaagttagaaatgaaaaagtttacgatcaattatctaaaatcgcaccaacagtt
tctactgatacagttttcaaattcaaagatacaactaagttaatggggaaagctttaggg
aaagaaaaagaagctgaagatttacttaaaaagtacgatgataaagtagctgcattccaa
aaagatgcaaaagcaaagtataaagatgcatggccattgaaagcttcagttgttaacttc
cgtgctgatcatacaagaatttatgctggtggatatgctggtgaaatcttaaatgattta
ggattcaaacgtaataaagacttacaaaaacaagttgataatggtaaagatattatccaa
cttacatctaaagaaagcattccattaatgaacgctgatcatatttttgtagtaaaatca
gatccaaatgcgaaagatgctgcattagttaaaaagactgaaagcgaatggacttcaagt
aaagagtggaaaaatttagacgcagttaaaaacaaccaagtatctgatgatttagatgaa
atcacttggaacttagctggcggatataaatcttcattaaaacttattgacgatttatat
gaaaagttaaatattgaaaaacaatcaaaa
319.
atgattaatcagtctatatggcgcagtaactttcgcattttatggctcagtcagtttata
gcgattgctggactgacagtacttgtgccattattgccaatttatatggcatcactacaa
aatctatcagtcgtagaaatacagttgtggagtggtatagcgattgctgctccagctgta
acgacgatgatagcttcgccgatatgggggaagctaggtgataagatcagccgaaaatgg
atggtgttaagagcgttacttggtttggcggtatgcttatttttaatggcattgtgtacg
acaccattacagtttgtacttgtgaggttattgcagggactatttggtggtgttgttgat
gcatcaagtgcgtttgcgagtgcagaggcgccagctgaagatcgtggaaaggtattagga
agactgcaaagttcagtcagcgcagggtctcttgtggggccattaattggcggtgttaca
gcttcgatattaggttttagtgcgttactgatgagtattgccgttattacttttattgtc
tgtattttcggtgcattaaaattgattgaaacgacacatatgccaaaatcacaaacacca
aatattaataaaggtattcgccgttcatttcaatgtctattatgcacacaacaaacatgt
cgatttattatcgttggcgttttagcaaactttgctatgtatggcatgctaactgcatta
tcaccacttgcttcatcagtgaatcatacagcgatagatgaccgtagtgtgattggattt
ttacagtccgcattttggacggcttcgatattaagcgcgcctttatggggacgctttaat
gataaatcatatgttaaatcagtatatatatttgccacgattgcatgtggttgtagtgcg
atactgcaaggtttagcgacgaatatagagtttttaatggctgcaagaatacttcaagga
ttaacatatagtgcattgattcaaagtgtcatgtttgttgtcgtgaatgcgtgtcatcaa
caacttaaaggcacatttgttggaacgacgaacagtatgttagttgttggtcaaattatt
ggcagtcttagtggcgctgccattacaagttatactacaccagctactacgtttatcgtt
atgggcgtagtatttgcagtaagtagtttatttttaatttgttcaaccatcactaatcaa
atcaacgatcacacattaatgaaattatgggagttgaaacaaaaaagtgcaaaa
320.
atgaagcgattattcgatgtagtgagttcaatatatggtttagtagttttaagtccgatt
ctgttaattacagcattactaattaaaatggaatcacctggaccagccattttcaaacaa
aaaagaccgacgattaataatgaattgtttaatatttataagtttagatcaatgaaaata
gacacacctaatgttgcaactgatttaatggattcaacatcgtatataacaaagacaggg
aaggtcattcgtaagacctctattgatgaattgccacaattattgaatgttttaaaagga
gaaatgtcaattgtaggtcctagaccagcgctttataatcaatacgaattaatcgaaaaa
cgtacaaaagcgaacgtgcatacgattagaccaggtgtgacaggactagctcaagtgatg
gggagagatgatatcactgatgatcaaaaagtagcgtatgatcattattacttaacacat
caatctatgatgcttgatatgtatatcatatataaaacaattaaaaatatcgttacttca
gaaggtgtgcatcac
321.
atggcacaacttaattcaaagatagcttccttaaaattattcgcaagttacgccatagca
acttatattttagttatattaacgagtgcattaaatctttttaaaggttatgtggccgat
acgttctatattgctgaaacattgctaatcgttttaaccatcattttaattattatttta
acaacggaacaaacatggaagcatcatgacctatggcgacgtatcgtcgaagtgttgtta
ttgttgatgacattaacaggcaacgtatttacattattaatgtttgtaagtattagacgt
taccaacgtacatcgcaaatacatagttataacgggtgggaatcgtttatacgaaaaact
actagacatcgtattgcgattatcgggttacttattttagtctacatgctgacattatca
attgtgtcacaatttacatttgatacgacattggctactaaaaatcagttcaatgcactg
ttacatggaccgagtctagcctatccgtttggtactgatgatttcggtagagacttattt
acacgcgtagttgtaggaacgaagctgacattttcaatttcaattatttcagtagttatt
gcagttatttttggtgtgttactaggcactatcgcaggttattttaatcatattgataat
ttaataatgcgaattttagatgtagtgtttgcaattccatcattattgttagcggtggca
attattgcatcatttggagcaagtattccaaatttaattattgctttaagtatcggtaat
ataccatcatttgcacggacaatgcgtgccagtgttttagaaattaaacgcatggaatat
gtagatgcagcacgtatcactggtgaaaacacttggaatatcatatggcgttatatttta
ccgaatgcgattgcgcctatgattgtacgtttttcattaaatataggtgtggttgtatta
acaacaagtagtttaagtttcctaggacttggtgttgcacctgatgtagctgaatggggc
aacattttacgtaccggtagtaactacttggaaacgcacagtaatttagctattgtacct
ggtgtttgtattatgttcgtcgttttagcatttaattttataggtgatgcagtgcgtgat
gcactagatccaagaattcat
322.
atgaaaacaatacatttgtttcgcatctaccactcttttttattgaaaaagtggtatttg
attatctatttactatttatattagcggcactccttattacattaacgacaatccaacat
gtaacagaagatgacaatcattttaatataggtgtcgtagataaagatcaatcaagtgaa
acgaaattaatcttaaactctattggtaaagggagtaacctaggaaaaaacgtgagcatt
aaagcatatgatgataagcaagcacatactttgttaaaaaaacataaacttcaaggctat
tttgtttttgataaaggtatgaccaaggcattttataaacaaggcgaactaccaatttca
gtatatacatatgatcaacaatccatgaaaagtgtcgtgctatctcagctaacagattct
gtttaccaacgtcttatgcgatcaatgggtggcatcttagcttttcaagacttagcaccg
aaagcatcacattctgacagtatcaatgttatgactgatttgctgattacaggattaaac
cgttcaggtgcatttaacttagaaccgattcatttatacgatacgggcagttattatgca
attacaggatttttaacaacggtattcatctttgcactatctttatttacagttttgaaa
atgaatcaagatactgtattgaaagcgcgattgaaaatgtttcatttttctaaagagcgt
ttattaatcattcgtacgttgattacatggttttatactatgttatggagtatcgttggt
gtagtttggattgtgttcagtattccgaatatctttgaattatataattggccaacgtta
gccattcatttaagctattatgttacctttttaatactgtggttattactcatcgaactt
ttaacaacaggcttgttgaatagtattagtaaagtcatattagctattgtcatcctggtg
ttatctggtttaacaatacctacgatttttttacaacatatagcaaatggtgttttcaat
attcaaccgttcgcagttgtaacaaatcaattgttagaaattattttaaacaactacatt
ttagaactgcaccctagtttctatcttagcttcatcgcacttttgataattaatttagct
gtattggtttggaggtatcgtcaa
323.
ttgaaaaaacaagttattatttcgggcctcatgttattttcactattttttggagccgga
aatttaatattcccgcccatgcttggccatacagcgggtcaaaatatgtggattggtatg
ctaggctttgcccttacaggcatattactcccctttattactgttattgttgttgcattt
tatgatgaaggtgttgaaagtgtaggcaatcgtatacatccatggttcgggtttattttt
gctgtcgtgatttacatgtctatcggagcattttacggtattccacgtgctgcaaatgtc
gcgtacgaaattggtacaagacacattttacctgtgcataaccaatggactttaattata
ttcgcagcaatcttttttgccatcgtttactggattagtttaaatccatcgaaaatcgtt
gataatttaggtaaattattaacaccgttattactattaatggtcgctctattaagtatt
gctgtcattttcaaccctgaatctgcactaagtgcacctaaggataaatatataacacat
cctttcatttcaggaagtttggaaggctattttacaatggatcttgttgctgcgttagct
ttttccgtagtcattgtcaatggctataagtttaaaggcctcacagatcgcatgaaaatt
ttaaaatatgtctgcttttcaggtcttattgcagccatattacttggaatgatttacttt
gcacttgcatacgttggggcatcaacagctccaggaaactttaaagatggtacagatata
ttgacgtacaactcattacgattatttggttcgttcggtaacctcgtatttggaatgacg
gttatccttgcatgcctaacaacatgtataggactcgtcaatgcttgcgccacatttact
aagaaacacgtacctaagttttcttataaaatattcgcacttattttctctatcataggg
ttcttatttacaacacttggtttagaaatgattttaaaaattgctgtcccattattgact
ttaatatatcccgtgtcgattgcacttgtactcatatcatttgctaacatgtttagcaca
ttcagattcagttgggcctatcgactcgcaactgttattacattgattatttcaatttta
caaatactaaatagtttcaacttattacacggtgttattttgaaatcgtttatgatgtta
cctttagcagatatcgatttagcttggcttgtaccattcatgctctttgctattatcggt
ttcataatcgatgtatttatacgccgtccgaaacaagcgacaact
324.
gtgaaacattatttgactaaatttgtagcaatgctaataactgctgctatggtgtgtagc
tttgggttactgaaaagtcaggcagcagaacaacaaagtattagtgatgtatatagtgtg
ataacggatgcgaaatctgcactttctaataattcgatatcgaatgacaataagcagaaa
gcaattgagcaagtggtaagtgcagttaagaaattatcgcttgaagataatagtgaaagt
aatgctgtcaaatcagatgtgagaaagcttgaagatgcaaaagcgaatgataatcaaaaa
gatacactttcgcaattaacgaagtcattaattgcttatgaagagaaattggctagtaaa
gatgcgggttctaaaattaaactattgcaacagcaagtcgatgctaaagatgctgcgatg
acaaaagcgattaaagataaaaataaagcggaattagaatctttgaacaatagtttgaat
cagatttggacaagtaatgaaacagtgattcgcaattatgacgcaaatcaatatggacaa
attgaagtcgcattattacaacttagaattgcaattcataagtcaccattagatacggca
aaagtgtcacatgcttggacaacttttaaatcaaatattgatcatgtcgataaaaaaagt
aatacgtctgcaaatgatcaataccatgtatcacaattaaatgatgcgttagagaaggcg
attaaagctatcgacgacaatcaattgtcggatgctgatgctgcgcttacacattttata
gaaacttggccgtatgttgaaggtcaaattcaaactaaagacggtgctttgtatacgaaa
attgaagataaaataccatattatcaaagtgtattagacgaacataataaagcacatgtg
aaagatggtttagtagatttaaataaccaaattaaagaggttgttggccatagttatagc
ttcgtcgatgtgatgattatctttttacgtgaagggctagaagtgttgttaattgtaatg
acattgactaccatgacgcgtaatgtaaaagataagaaagggactgcaagtgtgattggt
ggtgcaattgccggacttgtactgagtattatcttagcaattacgtttgtagaaacttta
gggaatagtggcattcttcgtgaaagtatggaagcgggattaggtatcgttgcggtcata
ttaatgtttatcgttggtgtttggatgcacaaacgttcaaatgcaaaacgttggaatgac
atgattaaaaatatgtatgctaatgcgattagtaatggtaatttggtattgttagcgacg
attggtttaatatctgtgttgcgtgaaggtgtcgaggttatcattttctatatggggatg
ataggtgagctagcgaccaaagattttattattggtattgctttagctatcgttatttta
atcatctttgcattattatttagatttatagttaaattaatacctattttctatatattt
agagtgttgtcgatctttatttttattatgggattcaaaatgcttggcgtaagtattcaa
aagttacaattattaggtgcgatgccaagacatgttattgaaggattcccaacgattaac
tggttgggcttttatccaagttatgaaccattgatagcacaaggtgcttatattatggta
gttgctatcttaatctttaaatttaaaaaa
325.
mnkqifvlyfnifliflgiglvipvlpvylkdlgltgsdlgllvaafalsqmiispfggt
ladklgkkliiciglilfsvsefmfavghnfsvlmlsrviggmsagmvmpgvtgliadis
pshqkaknfgymsaiinsgfilgpgiggfmaevshrmpfyfagalgilafimsivlihdp
kksttsgfqklepqlltkinwkvfitpviltlvlsfglsafetlyslytadkvnyspkdi
siaitgggifgalfqiyffdkfmkyfseltfiawsllysvvvlillvfandywsimlisf
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326.
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327.
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328.
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329.
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330.
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331.
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332.
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333.
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334.
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rqvlidlnndev
335.
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vdtrraiyfipiwfillafmylrykriaaksnk
336.
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vannrglansaqntpnqsattnqatnqalvnhnngsivnqatptsvqsstpsaqnnnhtd
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lplkefalitgaallarrrtknekes
337.
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338.
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atgfiatydsgldgpaigflaeydalpglghacghniigtasvlgaiglkqvidqiggkv
vvlgcpaeeggengsakasyvkagvidqidialmihpgnetyktidtlavdvldvkfygk
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gakimalmglelitnqdvyqdiieehahlkgngk
339.
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qstqrmtheelrvdnqddhsqvslngytkgsekdqeaftnnkdeeavaaknpeseeykvn
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ndafivatifsiialilclflqsnkkakataqkldadnsinhe
340.
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qfdfvkdkkynkdalvvkmqgfissrttysdlkkypyikrmiwpfqynislktkdsnvdl
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vkiksitpk
341.
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glalgqfifgplsdafgrkriavsiliifilvsglsmfvdqlplfltlrfiqgltgggvi
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342.
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343.
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klplypvlpaitfvlvllvfwglgfeaklytliwfivgiilylsyglrhskkndvaeyhp
pk
344.
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dqvinvvimfifaiiffgimndsglfkplvkrlilmtrgnvvivcamtaligtiaqldga
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345.
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346.
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ltskesiplmnadhifvvksdpnakdaalvkktesewtsskewknldavknnqvsddlde
itwnlaggyksslkliddlyeklniekqsk
347.
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gslsgaaitsyttpattfivmgvvfavsslflicstitnqindhtlmklwelkqksak
348.
mkrlfdvvssiyglvvlspillitallikmespgpaifkqkrptinnelfniykfrsmki
dtpnvatdlmdstsyitktgkvirktsidelpqllnvlkgemsivgprpalynqyeliek
rtkanvhtirpgvtglaqvmgrdditddqkvaydhyylthqsmmldmyiiyktiknivts
egvhh
349.
maqlnskiaslklfasyaiatyilviltsalnlfkgyvadtfyiaetllivltiiliiil
tteqtwkhhdlwrrivevllllmtltgnvftllmfvsirryqrtsqihsyngwesfirkt
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trvvvgtkltfsisiisvviavifgvllgtiagyfnhidnlimrildvvfaipslllava
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pnaiapmivrfslnigvvvlttsslsflglgvapdvaewgnilrtgsnylethsnlaivp
gvcimfvvlafnfigdavrdaldprih
350.
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tklilnsigkgsnlgknvsikayddkqahtllkkhklqgyfvfdkgmtkafykqgelpis
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lttgllnsiskvilaivilvlsgltiptiflqhiangvfniqpfavvtnqlleiilnnyi
lelhpsfylsfialliinlavlvwryrq
351.
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ydegvesvgnrihpwfgfifavviymsigafygipraanvayeigtrhilpvhnqwtlii
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frfswayrlatvitliisilqilnsfnllhgvilksfmmlpladidlawlvpfmlfaiig
fiidvfirrpkqatt
352.
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iifallfrfivklipifyifrvlsififimgfkmlgvsiqklqllgamprhviegfptin
wlgfypsyepliaqgayimvvailifkfkk
353.
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aaagtaacccaagaatctcaagcaactaacgcattgaaagagttaccaaaatctgaaaat
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ggtagcccaattatttcaatcgcacatgtaaataacttccaaggtcaagataacagaaac
aatgcagcttggattggtgataaaatgatttacggtgacggtgatggacgtacatttaca
gcgttgtctggtgcgaatgatgttgttgcacatgaaattacacatggtgtaacacagcaa
actgctaatcttgtttaccgttctcaatcaggtgcattaaatgaaagtttttcagatgta
tttggttacttcattgatgatgaagatttcttaatgggtgaagatgtttacacacctggt
gtaggcggagatgccttaagaagtatgtctaatccagagcgttttggacaaccatctcat
atgaatgattttgtttatacaaattctgacaacggaggcgtacatacgaattcaggtatt
ccgaacaaagcagcttacaacacaattcgtagtattggtaaacaacgttctgaacaaatt
tattatagagcgttaactgtttatttaacttcaaattctgatttccaagatgccaaagca
tcattacaacaagcagcatttgatttatatggcgacggtattgctcaacaagtaggtcaa
gcatgggacagtgttggcgtg
354.
atgtctaaacatagtgctacgttagttattatgtttttaataactttattgcctattttt
caatatcaagcttctgcacatgcgactttagaaaaatcaacaccacaacagcaaggggtt
attaaagacaaaccagaagcaatcaagttagagtttaatgaacctgtgaacaccaaatac
tcgagtgtgaccttatttgatgataaaggtaaaaagattaaagaccttaaaccaataaca
actggatggtctcagacagttgtattttcatctgagcaaattgttaatggcacgaatact
attgaatggcatacggtatctgcggatggacatgaagtcggagatacgtttgaattttca
gttggaaaagtgaggctaaagatg
355.
atgaaaaaaatcaaaacaatctcgacattggtagctggacttggtatagcatttctaggt
cacacaacacatgcagatgcggctgaaaataacaatcaacaacaaagtacatataactat
agtacaactgaagtatcattttctaattcaggaaatttatatacttctggccaatgtact
tggtatgtttatgataaaactggtggaaaaatcggatcaacatgggggaatgcaaatagc
tgggcaactgcagctcaagcagcaggattcactgtaaataatacacctgaagaaggtgca
attatgcaatcatctgaaggtgctttcggacatgttgctttcgttgaaagtgtcaataat
gatggttctattactgtatcagaaatgaactatgatggtggtccattcgctataagcaca
cgaacaatctctgccagtgaagcaagttcatataattacatccacctgaat
356.
atgaaaaaaatcgctacagctacaattgcaactgcaggaatcgctactttcgcatttgca
caccatgacgcacaagcagcagaacaaaataatgatgggtacaatccaaacgacccttat
tcatatagctacacttacacaatcgatgctgaaggtaactaccactacacttggaaaggt
aactggagtccagatcgtgtaaatacttcatataactataataattataataactacaac
tactatggttacaataactatagcaactacaataactacagtaattacaacaattacaac
aactatcaatcaaacaacacgcaatcacaaagaacaactcaaccgactggtggtttaggc
gcaagctattcaacatcaagtagtaatgttcacgttacaacaacttctgcgccatcatca
aacggtgtatctttatcaaacgctcgctcagcatctggtaacttatacacttcaggtcaa
tgtacatattatgtatttgacagagtaggtggcaaaatcggttcaacgtggggtaacgca
aacaactgggcaaacgctgcagcacgttctggttacacagtaaacaattcacctgctaaa
ggtgcaatcttacaaacgtcacaaggtgcatacggacacgtagcatacgttgaaggtgta
aacagcaatggttcaatcagagtttcagaaatgaactacggtcacggtgcaggtgttgtc
acttcacgtacaatctctgcgagtcaagctgcttcatataactatattcac
357.
ttggaagataaaaaagctccagtaaatgaagactttttaaattacatcaaaaactatgcc
gatgtaagaaacatacctctttcaagacgtaagatggcctcgttgtttcacacttctaaa
actgcaattgatgatgtctcacaagaaaaactaaatacttggttacgaaaacctgataag
ttttacgtgaatattatcgagctttcgaaagacttatattacaagtctggtgaatatcgt
agcttacttaattactttattgatatggctcgtttctattatgtgattgatccattgttt
agcagcgatagtaagatgagcaaggagaaagtcaaaaaagacctctctaaaatatcttta
caacttaataaaatgaatttaaaacatgagttagctaaaatttacaaaacatgtgtactt
gaagatattttctttggttatgaaatcgaagataaagacaattacttcatgttaaaactt
gatccaaagtattgtaaattagttggtatctctgacgggatgtatacatatgctttcaac
ctgtcctattttgacggtaatttagatttattaaaaacattcccagaagagtttcaaaga
gcatatttagaacgctctattgataagcaagctgacttaaattggtttattccagacttc
actaaatcagttgttttcaaaattaatgaagacgatcctactattttacctccattttct
acaatgtttgaacccctattagatttaaacgattataaaaagcttaaaaaagctggagct
aaaattaataactacatgttattacatcaaaaagtgccaatgcatgataatgcaaataaa
gattatcaagctgataacttcgcaatctcagctgaggcaatggactacttcagcgagtta
gttaacgaaaacttaccagatgaaattggttctatcgtttcccctatggaagttaaccct
attaaattagatagagatgataaaactgataaggtacttgaagctactagagatgtttat
aacgcttctggtgtttcttcatttatctttaacaatgataaaaactctactggtggttta
acttactcagttcgtaaagatgagttattcgtaattaatttctaccgacaagttgagaga
tggttaaatcgtaaaatcagatatggcaatatcgtagccaaaaatcaatggagaatttct
ctattaaatgtaactggaatgagtgaagatacttacttagagcaattaactaagtctggt
acattcggtttctcagttagaggacgtattgctgcattacatggtttagattaccataca
ttatctcaaagtttagaattagaaaacaatatcttagatttagatactaatttaatacct
cttgctagttctcatactggtggtttaaatactgctgttgaacaaacaaaaggaaaaata
gaagactctggtggcagacctactaaagaaactaaagacttgtctgatagcggacaagca
aatcgtgactctagtaattctgagacaaaatctttagaaggtggtgacactaataatgaa
358.
gtgggagtcgtgtcaatcattactgggattacaatatttgtcagtggtcagcatgctcaa
gctgctgaaatgacacaatcatcatcagattctaacgaacagtcacaacaaacagaacaa
gttgaacacaaagaagatacaactcatttatcttacgaattgaatcaagagggtgagaca
gcgagccaatcaaagactagtcaagagaatcaatctgatggcaatgtacaaaaaaagagt
aatcaaatacaacaagattcaacacaaacgtcaccattaaatgaccaaaaacaaacttca
atggaacaacaatcaaaagacaatcatgttaccccaaattcacgtcaggatacatatcca
aaaggccaaaatcaagatgataaaggcaaacaacagtttaaagataatcaacactcacaa
acagaacatcaacctaatactcaaaaccaaaataatgatcaagattcatcagataaaaag
caacacccatctgatcaaactcaagactcatcttcaaaaggaacacaacctaaacaatca
cagtctatagaagatagagataaaacagtaaaacaaccatcttctaaagtacacaaaata
ggtaacacaaaaactgataaaacagttaaaacaaatcaaaaaaagcaaacatcattaact
tcaccacgcgttgtgaaatcaaaacaaactaaacatatcaatcaacttactgcgcaagct
caatataaaaatcaatatccagtcgtgtttgtacatggatttgtaggtttagtcggtgaa
gatgcattcagcatgtacccaaattattggggtggtactaaatataacgtgaaacaagaa
cttacaaaattaggttaccgagttcacgaagccaatgtaggggcatttagcagcaattat
gaccgtgctgttgaactgtattattatattaaaggtggaagagtagattatggtgcagca
catgctgcaaaatatggtcacaagcgttatggcagaacatatgaaggcatcatgcctgat
tgggaaccaggtaaaaagatacatcttgttggacatagtatgggtggccaaacgatacgc
ttgatggaacattttttaagaaatggaaatcaagaagaaatagattatcaacgtcaatat
ggtggtacggtatccgatttatttaaaggtggacaagataatatggtgtctacgattact
acattaggaacgcctcataatggcacacctgctgcagataaactagggtcgactaaattt
attaaagatacaattaatagaattggaaaaattggtggaactaaagcgctcgatttagaa
ctaggtttttctcaatggggcttcaaacagcaacctaatgaatcatatgctgaatatgca
aaacgtatagcgaatagtaaagtttgggagactgaagatcaggctgtaaatgatttaaca
actgctggagcagaaaagttaaaccaaatgacgacattgaatcctaatatcgtctataca
tcatatacaggtgctgcaacacatactggaccattaggcaatgaagtgccgaatattaga
caattcccactattcgatttaacaagtcgtgtgataggtggagatgataataaaaatgtc
agagtaaatgatggcatagtacctgtgtcttcttcactacatccaagtgatgaagcattt
aagaaggtaggtatgatgaacctagcaactgacaagggtatctggcaagtgagacccgta
caatatgattgggatcatctagatttagtcggcttagatactactgattataagcgaact
ggagaagaattaggtcaattctatatgagtatgataaataatatgttgaaagtcgaagag
ttagatggtattacacgtaag
359.
mknfskfaltsiaaltvasplvntevdakdkvsatqnidakvtqesqatnalkelpksen
ikkhykdykvtdtekdnkgfthytlqpkvgntyapdkevkvhtnkegkvvlvngdtdakk
vqptnkvaiskesatdkafeaikidrqkaknlksdviktnkveidgeknkyvynieiitt
spkishwnvkidaetgqvvdklnmikeaattgtgkgvlgdtkqininsvsggytlqdltq
qgtlsaynydantgqaylmqdkdknfvddeqragvdanyyaketydyykntfgresydnq
gspiisiahvnnfqgqdnrnnaawigdkmiygdgdgrtftalsgandvvaheithgvtqq
tanlvyrsqsgalnesfsdvfgyfiddedflmgedvytpgvggdalrsmsnperfgqpsh
mndfvytnsdnggvhtnsgipnkaayntirsigkqrseqiyyraltvyltsnsdfqdaka
slqqaafdlygdgiaqqvgqawdsvgv
360.
mskhsatlvimflitllpifqyqasahatlekstpqqqgvikdkpeaiklefnepvntky
ssvtlfddkgkkikdlkpittgwsqtvvfsseqivngtntiewhtvsadghevgdtfefs
vgkvrlkm
361.
mkkiktistlvaglgiaflghtthadaaennnqqqstynysttevsfsnsgnlytsgqct
wyvydktggkigstwgnanswataaqaagftvnntpeegaimqssegafghvafvesvnn
dgsitvsemnydggpfaistrtisaseassynyihln
362.
mkkiatatiatagiatfafahhdaqaaeqnndgynpndpysysytytidaegnyhytwkg
nwspdrvntsynynnynnynyygynnysnynnysnynnynnyqsnntqsqrttqptgglg
asystsssnvhvtttsapssngvslsnarsasgnlytsgqctyyvfdrvggkigstwgna
nnwanaaarsgytvnnspakgailqtsqgayghvayvegvnsngsirvsemnyghgagvv
tsrtisasqaasynyih
363.
ledkkapvnedflnyiknyadvrniplsrrkmaslfhtsktaiddvsqeklntwlrkpdk
fyvniielskdlyyksgeyrsllnyfidmarfyyvidplfssdskmskekvkkdlskisl
qlnkmnlkhelakiyktcvlediffgyeiedkdnyfmlkldpkycklvgisdgmytyafn
lsyfdgnldllktfpeefqraylersidkqadlnwfipdftksvvfkineddptilppfs
tmfeplldlndykklkkagakinnymllhqkvpmhdnankdyqadnfaisaeamdyfsel
vnenlpdeigsivspmevnpikldrddktdkvleatrdvynasgvssfifnndknstggl
tysvrkdelfvinfyrqverwlnrkirygnivaknqwrisllnvtgmsedtyleqltksg
tfgfsvrgriaalhgldyhtlsqslelennildldtnliplasshtgglntaveqtkgki
edsggrptketkdlsdsgqanrdssnsetksleggdtnne
364.
vgvvsiitgitifvsgqhaqaaemtqsssdsneqsqqteqvehkedtthlsyelnqeget
asqsktsqenqsdgnvqkksnqiqqdstqtsplndqkqtsmeqqskdnhvtpnsrqdtyp
kgqnqddkgkqqfkdnqhsqtehqpntqnqnndqdssdkkqhpsdqtqdssskgtqpkqs
qsiedrdktvkqpsskvhkigntktdktvktnqkkqtsltsprvvkskqtkhinqltaqa
qyknqypvvfvhgfvglvgedafsmypnywggtkynvkqeltklgyrvheanvgafssny
dravelyyyikggrvdygaahaakyghkrygrtyegimpdwepgkkihlvghsmggqtir
lmehflrngnqeeidyqrqyggtvsdlfkggqdnmvstittlgtphngtpaadklgstkf
ikdtinrigkiggtkaldlelgfsqwgfkqqpnesyaeyakrianskvwetedqavndlt
tagaeklnqmttlnpnivytsytgaathtgplgnevpnirqfplfdltsrviggddnknv
rvndgivpvssslhpsdeafkkvgmmnlatdkgiwqvrpvqydwdhldlvgldttdykrt
geelgqfymsminnmlkveeldgitrk
365.
tcaataaggtgctttctaaagaatttttctccccatgtccaatctataaataaatctttg
gttaaaaattgcgacacaaccattctcattcgattatgcataaaaccagtttgtgtcaat
tccattattgctgcatcaatgattggaaatcctgtttgcccttcgcaccatgcattaaaa
tccgcttcattttgcgaccattttatctgtcgatatttaggtttgaaagcttggtatgag
gtttcaggatactgtgtcattaacacataa
366.
ctgttgcaccatttggtccttttgcacctaagtcaattgatacttgcccagttgccatat
caggaattaacattggtacgaaaaatggactcacacgtcttgggcctttatccattaatt
gtttatgtgcaatttcaaatgtttccataccaccgataccagaaccaatccatacaccga
ttcgatctgcagtattttcat
367.
gatgcacctttaggtctaatacctggtgttacttttaaaaatgatgtacctaacttttca
gtcaacatacgactttcaagaggtgaacaaacaacgccatctaaaccagctgcatttgct
aacttggcataa
368.
tacatcaaaccactatgtttacccattttcttaccatcaagtgttatcatatcacccggt
tgtgcaggtaaatattgtgataaaaatgttttaaagtttttttcgccgataaaacaaatg
cctgtagaatcttttttcttagcagtaacaagtccttgttcttcagcaattcgacgcact
tcactcttttcgatgtcgccaattgggaacatcacttttgaaagttgttgt
369.
cgtttcgcatcttcatcatattctaataatggccaatctgtcacccataagaagtttaat
tttgtttcatcgattaaacctaattctttagctaatttgacacgtaatgcacctaaactt
tgtgcaacgacatttggtttgtctgcaacaaacattactaagtcaccagcttcagcacca
gttaatgtaagtaatgtttcaacattttctgtttcaaagaaacgtccaattggacctgtc
aaaccatcttccacaactttaacccacgctaatcctttagcacca
370.
cgtcaacgtcctgtccatgtgtttccaaaaaataataatccacatgggcaatataatcat
caatatcaacatcactacgtaacgctagcaaatgctttt
371.
atgaatgaagcatctaatttaatcttaaccatgccaaatgaatccaaagccgcaactaaa
atagcaaagattaagccgccaatcactggtgctggtatacaaatacgttttaaaaaatta
acg
372.
attctatcagccgcattatccacaccggcattattaaacaacacatcgattcttccaaac
tgttcctttatgtcagacacaaagtctaccacttgttgttcgcttgcattatccacatta
tacgccttcgcattgtcaccattacttttaattttatcgacagtctccgataccgcttca
gctatgtctaccgccaatacatacgcaccttat
373.
cctggcgctattgtttcaggtccgtattctgttaattcattaatcggatcttttgtaatc
tcttcttttggttcacctttactaataattactccagttaatggattttttagtgttggt
gtcgttattgtcttctcacctttttgtccttctcttgttactttttctgtccctggtgct
aaatccggattaaatttacgttctttcttgaatggaatctcttcaacttttttttctaat
tctgttattgtttttggcgcttctggtgtaaaagtaaactctgaacctttcaagtcagtt
ctcatccagccatttgcatttatccct
374.
ttactaacatttattgctgttaaacctacgatgacaaataaaataatagctaatactttt
aaaataactaaaatattttccatacgagctgcttccgacataccacgtgatagtaataat
gcagttaataaaataacgatagcagcaataatatcgataaaaccgccatttgtaccaaat
ggatttgataatgctgcaggtaattcgatgccaattggtttcacaagtccgcgtaaattc
gctgagaatcctgatgcaacaaaggctacggcgataaaatattcagctaatagagcccaa
ccggcaacccatccaaaaaattcaccaaataatacattgacccaagaa
375.
gatgtgttgaaactgagttcaattaaattatatgtttttattatacactttttgacatat
tttttaaatttaagaatgcgaagatttttaacatttctgatgctagctttctttttcatc
tttcaaatgcttaataaaatcaaagccaggtcgccctttagccaatgcttccatcacatc
ataccaatccgaaccgacttgttgatatatattttgcaa
376.
tctatcattgtaaatactgtatctaagtgcataaaagttcgactagttggaatttcaatt
gctactacttttttaaacgtcgcctgcggattttcaaaaatacgtcgcgctaacttttca
atagcttgtgcagatgtacgttctgaaacgcctatagccaagacatctttagataaaaca
agttcatcgccgccttcaatattgaatgggcaatctcgatctaaccagattggaatattc
gcatctttaaatctagga
377.
gaagtcttggccattcccttgagtaaacatgaagccccagccatctgctcctgttgtatt
accttggttgttgtttgctactggaacagtaattgtaaagtctttattaaaatctatttt
atcattatattctaa
378.
sircflknfsphvqsinkslvkncdttilirlcikpvcvnsiiaasmignpvcpshhalk
sasfcdhficrylglkawyevsgycvint
379.
llhhlvllhlsqlilaqlpyqeltlvrkmdshvlglyplivyvqfqmfpyhryqnqsihr
fdlqyfh
380.
daplglipgvtfkndvpnfsvnirlsrgeqttpskpaafanla
381.
yikplclpiflpssviispgcagkycdknvlkffspikqmpvesfflavtspcssairrt
slfsmspignitfescc
382.
rfasssysnngqsvthkkfnfvssikpnslanltrnapklcattfglsatnitkspasap
vnvsnvstfsvskkrpigpvkpssttlthanplap
383.
rqrpvhvfpknnnphgqynhqyqhhyvtlanaf
384.
mneasnliltmpneskaatkiakikppitgagiqirfkklt
385.
ilsaalstpallnntsilpncsfmsdtksttccslalstlyafalsplllilstvsdtas
amstantyapy
386.
pgaivsgpysvnsligsfvissfgsplliitpvngffsvgvvivfspfcpslvtfsvpga
ksglnlrsflngisstffsnsvivfgasgvkvnsepfksvliqpfafip
387.
lltfiavkptmtnkiiantfkitkifsiraasdiprdsnnavnkitiaaiisikppfvpn
gfdnaagnsmpigftsprkfaenpdatkataikysanraqpathpknspnntltqe
388.
dvlklssiklyvfiihfltyflnlrmrrfltflmlafffifqmlnkikarspfsqcfhhi
ipirtdlliyilq
389.
siivntvskcikvrlvgisiattflnvacgfskirranfsiacadvrsetpiaktsldkt
sssppsilngqsrsnqigifaslnlg
390.
evlaiplskheapaicsccitlvvvcywnsnckvfikiyfiiif
391.
cgttgcacaaagctgaatgttaaaaatgcggatccgccagcaatgactgcaatccaacaa
tctgatgcgacaccaccaaacataaataggaagaagccacatgcaatggcagctgcaaag
aaattcgttaaaaaagaatattgtaatgatgcatgctgtaaa
392.
rctklnvknadppamtaiqqsdatppninrkkphamaaakkfvkkeycndacck
393.
atgactaataaaagagaagatgtccgcaatatagcaattattgctcacgttgaccatggt
aaaacaactttagtagatgagttgttaaaacaatctggtatattcagagaaaatgaacat
gtcgatgaacgtgcaatggactctaacgatatcgaaagagagcgtggaattacgattcta
gccaaaaatacggctgttgattataaaggtacacgtattaatattttggatacaccagga
catgcagactttggtggagaagtagaacgtattatgaaaatggttgatggggttgtctta
gtagtagatgcgtatgaaggtacaatgcctcaaacacgttttgtacttaaaaaagcgcta
gaacaaaacctgaaacctgttgttgttgttaataaaattgataaaccatcagcacgtcca
gagggtgttgtagatgaagttttagatttatttattgaattagaagcaaacgatgaacaa
ttagaattccctgttgtttatgcttcagcagtaaatggtacagctagcttagatcctgaa
aagcaagatgataatttacaatcattatatgaaacaattattgattatgtaccagctcca
attgataacagtgatgagccattacaattccaagtagcattgttggactacaatgattat
gttggacgtattggtattggtcgtgtattcagaggtaaaatgcgtgtcggagataatgta
tcactaattaaattagacggtacagtgaaaaacttccgtgtaactaaaatctttggttac
tttggattaaaacgtttagaaattgaagaagcacaagctggagatttaattgctgtttca
ggtatggaagacattaatgttggtgaaactgtaacaccacatgaccatcaagaagcattg
ccagttctacgtattgatgagcctactcttgaaatgacatttaaagttaacaattctcca
tttgctggccgtgaaggtgactttgtaacagcacgtcaaattcaagaacgtttaaatcaa
caattagaaacagatgtatctttgaaagtttctaacacagattctccagatacatgggta
gttgctggtcgcggtgaattgcatttatcaatccttattgaaaatatgcgtcgtgaaggt
tatgaattacaagtttcaaaaccacaagtaattattaaagaaatagatggtgtaatgtgt
gaaccatttgaacgtgtgcaatgtgaagtgccacaagaaaatgcaggtgctgttattgaa
tcattaggtgcacgtaaaggtgaaatggttgatatgactacaactgataatggacttaca
cgtttaatctttaatgtaccggctcgtggtatgattggttatacgactgaatttatgtca
atgacaagaggttacggtattattaaccatacatttgaagaatttagaccacgtattaaa
gcacaaattggcggtcgtcgtaatggtgcattaatttcaatggatcaaggttctgcaagt
acttatgccattttgggacttgaagatagaggtgtaaacttcatggaacctggtactgaa
gtttatgaaggtatgattgttggtgaacataatcgtgaaaatgatttaactgttaacatc
actaaaacaaaacatcaaactaacgtacgttctgcaacgaaagaccaaacacaaacaatg
aatagaccgcgtattctaacattggaagaagcgttacaattcattaatgatgatgaactt
gttgtggttacaccagaaagtatacgtttaagaaagaaaattttaaacaaaaatgttcgt
gaaaaagaagcaaagcgtatcaaacaaatgatgcaagaaaacgaa
394.
gtgcttaggagtgatttttatatgtcttattccattgttagagtttcaaaagttaaatct
ggaacaaatacaacgggcatacaaaaacatgttcaaagagaaaataataattatgaaaat
gaagatatagaccatagtaaaacttacttaaattatgatttggtaaatgctaataaacag
aattttaataacttgattgatgaaaaaatcgaacagaattatacaggcaaaagaaaaatt
agaacagacgcgattaaacacattgatggtttaattacatcagacaatgatttctttgat
aatcaaacgccagaagatacaaagcagttttttgaatatgctaaagagtttttagaacaa
gaatacggtaaagataatttattatatgcaacagttcacatggacgaaaaaacaccacat
atgcattatggcgttgttccaataactgatgatggtcgtttaagtgctaaagaagttgta
ggtaataaaaaagctttaacagcgtttcaagatagatttaatgagcatgttaaacaacga
ggatatgatttagaacgtgggcaatcaagacaagtaacaaatgctaaacatgagcaaata
agtcagtataaacaaaaaacagaatatcataagcaagaatatgaacgtgagagccaaaaa
acagaccatataaagcaaaagaacgataaattaatgcaagagtaccaaaaatcgttaaat
acgcttaaaaagcctataaatgttccgtatgagcaagaaactgaaaaagtaggtggttta
tttagcaaagaaatacaagaaactggaaatgttgtaataagccaaaaagatttcaatgaa
tttcagaaacagataaaagctgctcaagatatttcggaagattacgagtatataaagtct
ggtagagccttagatgataaagataaggaaatacgagagaaagatgatttattaaataaa
gcagttgagcgtattgaaaacgcagacgataattttaaccaactttacgaaaatgcaaag
ccacttaaagagaatatagaaatagcgttaaagcttttaaaaatcttactaaaagagtta
gaacgagttttaggaagaaatacctttgcggaaagagttaataagttaacagaagatgaa
ccaaaacttaatggtttagcaggaaacttagataaaaaaatgaatccagaattatattca
gaacaggaacagcaacaagaacaacaaaagaatcaaaaacgagatagaggtatgcactta
395.
mtnkredvrniaiiahvdhgkttlvdellkqsgifrenehvderamdsndierergitil
akntavdykgtrinildtpghadfggeverimkmvdgvvlvvdayegtmpqtrfvlkkal
eqnlkpvvvvnkidkpsarpegvvdevldlfieleandeqlefpvvyasavngtasldpe
kqddnlqslyetiidyvpapidnsdeplqfqvalldyndyvgrigigrvfrgkmrvgdnv
slikldgtvknfrvtkifgyfglkrleieeaqagdliavsgmedinvgetvtphdhqeal
pvlrideptlemtfkvnnspfagregdfvtarqiqerlnqqletdvslkvsntdspdtwv
vagrgelhlsilienmrregyelqvskpqviikeidgvmcepfervqcevpqenagavie
slgarkgemvdmtttdngltrlifnvpargmigyttefmsmtrgygiinhtfeefrprik
aqiggrrngalismdqgsastyailgledrgvnfmepgtevyegmivgehnrendltvni
tktkhqtnvrsatkdqtqtmnrpriltleealqfinddelvvvtpesirlrkkilnknvr
ekeakrikqmmqene
396.
VLRSDFYMSYSIVRVSKVKSGTNTTGIQKHVQRENNNYENEDIDHSKTYLNYDLVNANKQ
NFNNLIDEKIEQNYTGKRKIRTDAIKHIDGLITSDNDFFDNQTPEDTKQFFEYAKEFLEQ
EYGKDNLLYATVHMDEKTPHMHYGVVPITDDGRLSAKEVVGNKKALTAFQDRFNEHVKQR
GYDLERGQSRQVTNAKHEQISQYKQKTEYHKQEYERESQKTDHIKQKNDKLMQEYQKSLN
TLKKPINVPYEQETEKVGGLFSKEIQETGNVVISQKDFNEFQKQIKAAQDISEDYEYIKS
GRALDDKDKEIREKDDLLNKAVERIENADDNFNQLYENAKPLKENIEIALKLLKILLKEL
ERVLGRNTFAERVNKLTEDEPKLNGLAGNLDKKMNPELYSEQEQQQEQQKNQKRDRGMHL
397.
atgactgttgaagaaagatccaatacagccaaagttgacattttaggggtcgattttgat
aatacaacaatgttgcaaatggttgaaaatattaaaaccttttttgcaaatcaatcaacg
aataatctttttatagtaacagccaaccctgaaatagtgaattacgcgacgacacatcaa
gcgtatttagagttaataaatcaagcgagctatattgttgctgatgggacaggagtagtc
aaagcttcgcatcgtttaaagcaacctctagcgcatcgtatacctggtattgagttgatg
gatgaatgtttgaaaattgctcatgtaaatcatcaaaaagtatttttgctaggggcaact
aatgaagttgtagaagcggcacaatatgcattgcaacaaagatatccaaacatatcgttt
gcacatcatcacggttatattgatttagaagatgagacagtagtgaaacgaattaaactg
tttaaacctgattacatatttgtaggtatgggattccctaaacaagaagaatggattatg
acacatgaaaaccaatttgaatctacagtgatgatgggcgtaggtggttctcttgaagta
tttgctggggctaaaaagagagcgccttatatctttagaaaattaaacattgaatggata
tatagagcattaatagattggaaacgtattggtagattaaagagtattccaatatttatg
tataaaatagccaaagcaaaaagaaaaataaaaaaggcgaaa
398.
mtveersntakvdilgvdfdnttmlqmveniktffanqstnnlfivtanpeivnyatthq
aylelinqasyivadgtgvvkashrlkqplahripgielmdeclkiahvnhqkvfllgat
nevveaaqyalqqrypnisfahhhgyidledetvvkriklfkpdyifvgmgfpkqeewim
thenqfestvmmgvggslevfagakkrapyifrklniewiyralidwkrigrlksipifm
ykiakakrkikkak
399.
atgagtgaaaattttaagttacgtaaaatgaaagtcggtttagtatctgttgcaattaca
atgttatatattatgacaaacggacaagcagaagcatctgaaaatcaaaacgctttaatc
tctaatataaatgtagacaatcaggaaaaacagaataatgtaaatcaagctgttcagcct
caaaataatactaatgaaacatcaaaagtaccggctaattttgtcaaattgaatgatatt
aaaccaggtgatacttctatacaaggaacaactttaccaaatcaatttatactattaact
attgataaaaaagatgtgagctcagttgaagattctgacagcagctttgttatgtctgat
aaagatgggaattttaagtatgacttaaatggtcgcaaaattgttcataatcaagaaatt
gaagtgtcttcatcagatccctatttaggtgacgatgaagaagatgaagaagtagaagaa
acttcaactgaagaagttggtgctgaggaagaaagtacagaagctaaagctacatataca
acaccgcgatatgaaaaagcgtatgaaataccgaaagaacagctaaaagaaaaagatgga
catcaccaagtttttatcgaacctattactgaaggttcaggtattattaaaggccatacc
tctgtaaaaggtaaagttgctctatctattaataataaatttattaactttgagacaaat
gctaatggtggtccaaataaagaagaagcgaaatctggatcagaaggaatctggatgcct
attgatgacaaaggatactttaattttgacttcaaaacgaaacgtttcgatgatttagag
ttaaagaaaaatgatgagatctcattaacatttgcacctgatgacgaagatgaggcattg
aagtcattaattttcaaaactaaggtaacgagtttagaagatattgataaagcagaaact
aaatatgaccatactaaagtggaaaaagtaaaagtattgaaagatgttaaagaagattta
catgtagatgaaatttacggaagcttatatcatacagaaaaaggtaaaggtattcttgat
aaagaaggtactaaagtaattaaaggtaagactaaattcgcaaatgcagttgtgaaggta
gactctgaactaggtgaaggtcaagaattccctgatttgcaagtcgatgraaaaggtgaa
ttcagctttgatgtagatcatgctggatttagattacaaaatggagaaacactaaacttc
acagtagttgatcctattacaggtgaattattaagtggaaattttgtttctaaaaacata
gatatttatgaatctcctgaagaaaaagcagatcgtgagtttgatgaaagaatggaaaac
acacctgcatatcataaattacatggtgataaaattgtcggctacgatactaacggattc
ccgattacctggttttatccattaggtgaaaagaaagttgaacgtaaggcaccaaaatta
gaaaaa
400.
msenfklrkmkvglvsvaitmlyimtngqaeasenqnalisninvdnqekqnnvnqavqp
qnntnetskvpanfvklndikpgdtsiqgttlpnqfilltidkkdvssvedsdssfvmsd
kdgnfkydlngrkivhnqeievsssdpylgddeedeeveetsteevgaeeesteakatyt
tpryekayeipkeqlkekdghhqvfiepitegsgiikghtsvkgkvalsinnkfinfetn
anggpnkeeaksgsegiwmpiddkgyfnfdfktkrfddlelkkndeisltfapddedeal
kslifktkvtsledidkaetkydhtkvekvkvlkdvkedlhvdeiygslyhtekgkgild
kegtkvikgktkfanavvkvdselgegqefpdlqvdxkgefsfdvdhagfrlqngetlnf
tvvdpitgellsgnfvsknidiyespeekadrefdermentpayhklhgdkivgydtngf
pitwfyplgekkverkapklek
401.
gtctatatgctatcaagtaccaggtttattgttaggtggtacaacaattgtaataagtcc
actaatatcattaatgaaagatcaagtggatcaattaaaagcgatgggaattcaagctgc
ttttttaaa
402.
vymlsstrfivrwynncnkstniinerssgsiksdgnsscffk
403.
tttaaatataaaaaaaacagaaaaatacctagtattatgatgcaacaaattaaaattact
atactatattcatatttaacgataaataaatgggaataccttcttaacataacaccaaat
aagaccgtacttcctgccactggccaaaaagaattgattttagctgtcttcacaatgttt
aaagtttcaaaatctttttcgctgattttgacgtacttttttggaatcagccaattaatc
attgggaaaaagagtgctaaccatgtacttactaaatcaatcatcaaatattcatctttg
tatttgataattctatatttgggattcttattaatattttcagtttcacaaagcaatgtc
tccacttcttttcaattggttttatat
404.
fkykknrkipsimmqqikitilysyltinkweyllnitpnktvlpatgqkelilavftmf
kvsksfsliltyffgisqliigkksanhvltksiikysslyliilylgfllifsvsqsnv
stsfqlvly
405.
ggaatgaaaatgatttcgatttccgatgaaatcaattgtttaatttgttgcaattgtgta
gggttatgttcttttatttcttctgctaagtatattttttggatttccatttcttctaac
actgtagctaagacatcaataaagcgtggtaagtttttagttacagctaggtcgatacga
cga
406.
gmkmisisdeincliccncvglcsfissakyifwisissntvaktsikrgkflvtarsirr
407.
tttgaagctacaaaggtaccgcataatggcagcacattaattaacaatgcgctaaacttt
aatgaggcgctgatttgcttgtctttaaaagtcaacatagcactgataattcctaaaata
gctactatacgtggaattgtcatgctcggatactgcggtatatgtaagaaagcaccaaga
cctgctatcacaccacatactaacgcaatatatagaaattgcttcaaatcattcactcct
aaattgttattacactattacaca
408.
featkvphngstlinnalnfnealiclslkvnialiipkiatirgivmlgycgickkapr
paitphtnaiyrncfksftpklllhyyt
409.
atgcttgctgctcgcatactattagaatctggtgcagaaggtacgcgtgtagaagatacc
atgacacgtattgcaaaaaaacttggttacagtgaaagtaacagctttgttacaaacact
gtcatccagtttacgttacattcggaatcgtttcctagaatatttagaattacctctcga
gatacaaacttaataaaaatttctcaagctaataaaatttcgcgtcaaattacaaacaat
gaaatttctttagccgaagcaaaaacgcaacttgaaaaaatatatgttgctaagcgtgac
agcagtcttccctttaaaggttttgctgcagcaatgattgcaatgagtttcttatattta
caaggtggtagattgattgatgttttaactgcgatattagcaggtagtctaggataccta
gtcactgagattttagatcgtaagttacacgcacagtttatcccagaattcattggttca
ttagttattgggattatcgccgttattggacatacacttattccaacaggtgacttggca
actattatcattgcggcagtcatgcctattgttcctggtgtattaataacaaacgcaata
caagatttatttggtggacacatgttgatgttcacaacgaaatcattagaagcattggtt
actgcgtttggcatcggtgctggcgttggtagcgtattaattttagta
410.
mlaarillesgaegtrvedtmtriakklgysesnsfvtntviqftlhsesfprifritsr
dtnlikisqankisrqitnneislaeaktqlekiyvakrdsslpfkgfaaamiamsflyl
qggrlidvltailagslgylvteildrklhaqfipefigslvigiiavightliptgdla
tiiiaavmpivpgvlitnaiqdlfgghmlmfttkslealvtafgigagvgsvlilv
411.
atgacatttaataaagtattattgagctggatagtcatattgattataacaactagcata
tatctattttggcagttgggcgatatcaatgatgtatttaaccagtctattttaatcaat
gttagattaccgagattattagaagcattgttgacaggtatgatattaactgttgcaggc
cttatatttcaaacagttttaaataatgcattggcagatagctttacattaggattggca
agcggcgctacatttggttcaggattagcattatttttaggtttaacaacgttatggatt
cctgtattttcaataacatttagtttgataacattaataactgtattagtcattacgtcg
gtattgagccaaggctatccagttagaatcttaatattaagtggtttaatgattggtgcg
ttattcaattcacttctatattttttgattttattaaaacctcgcaaattaaatacaatt
gccaattatctgtttggtggttttggtgatgcagaatactcaaatgtatctataatagca
atcacatttatcattgcattgtttggtatatttatcattcttaatcaactaaagttattg
caattaggagaactaaaaagtcagtcactaggcttaaatgttcaattgattacatatatc
gcgttatgtatagcttctatgataacggcgataaatgtcgcatatgttggcatcattgga
ttcattggtatggtgataccgcaactcattagaaaatggcagtggaaacaatcattagga
agacaattggctttaaatattgtaactggaggacaaataatggttatggcagattttatt
ggtagccatatattgtcaccagtacaaataccggcaagtattatcattgcattaattggt
ataccagtgttattttacatgctaatatctcagtcgaaacggttacac
412.
mtfnkvllswiviliittsiylfwqlgdindvfnqsilinvrlprllealltgmiltvag
lifqtvlnnaladsftlglasgatfgsglalflglttlwipvfsitfslitlitvlvits
vlsqgypvrililsglmigalfnsllyflillkprklntianylfggfgdaeysnvsiia
itfiialfgifiilnqlkllqlgelksqslglnvqlityialciasmitainvayvgiig
figmvipqlirkwqwkqslgrqlalnivtggqimvmadfigshilspvqipasiiialig
ipvlfymlisqskrlh
413.
atgaacaaacagcaaaaagaatttaaatcattttattcaattagaaagtcatcactaggc
gttgcatctgtagcaattagtacacttttattattaatgtcaaatggcgaagcacaagca
gcagctgaagaaacaggtggtacaaatacagaagcacaaccaaaaactgaagcagttgca
agtccaacaacaacatctgaaaaagctccagaaactaaaccagtagctaatgctgtctca
gtatctaataaagaagttgaggcccctacttctgaaacaaaagaagctaaagaagttaaa
gaagttaaagcccctaaggaaacaaaagaagttaaaccagcagcaaaagccactaacaat
acatatcctattttgaatcaggaacttagagaagcgattaaaaaccctgcaataaaagac
aaagatcatagcgcaccaaactctcgtccaattgattttgaaatgaaaaagaaagatgga
actcaacagttttatcattatgcaagttctgttaaacctgctagagttattttcactgat
tcaaaaccagaaattgaattaggattacaatcaggtcaattttggagaaaatttgaagtt
tatgaaggtgacaaaaagttgccaattaaattagtatcatacgatactgttaaagattat
gcttacattcgcttctctgtatcaaacggaacaaaagctgttaaaattgttagttcaaca
cacttcaataacaaagaagaaaaatacgattacacattaatggaattcgcacaaccaatt
tataacagtgcagataaattcaaaactgaagaagattataaagctgaaaaattattagcg
ccatataaaaaagcgaaaacactagaaagacaagtttatgaattaaataaaattcaagat
aaacttcctgaaaaattaaaggctgagtacaagaagaaattagaggatacaaagaaagct
ttagatgagcaagtgaaatcagctattactgaattccaaaatgtacaaccaacaaatgaa
aaaatgactgatttacaagatacaaaatatgttgtttatgaaagtgttgagaataacgaa
tctatgatggatacttttgttaaacaccctattaaaacaggtatgcttaacggcaaaaaa
tatatggtcatggaaactactaatgacgattactggaaagatttcatggttgaaggtcaa
cgtgttagaactataagcaaagatgctaaaaataatactagaacaattattttcccatat
gttgaaggtaaaactctatatgatgctatcgttaaagttcacgtaaaaacgattgattat
gatggacaataccatgtcagaatcgttgataaagaagcatttacaaaagccaataccgat
aaatctaacaaaaaagaacaacaagataactcagctaagaaggaagctactccagctacg
cctagcaaaccaacaccatcacctgttgaaaaagaatcacaaaaacaagacagccaaaaa
gatgacaataaacaattaccaagtgttgaaaaagaaaatgacgcatctagtgagtcaggt
aaagacaaaacgcctgctacaaaaccaactaaaggtgaagtagaatcaagtagtacaact
ccaactaaggtagtatctacgactcaaaatgttgcaaaaccaacaactgcttcatcaaaa
acaacaaaagatgttgttcaaacttcagcaggttctagcgaagcaaaagatagtgctcca
ttacaaaaagcaaacattaaaaacacaaatgatggacacactcaaagccaaaacaataaa
aatacacaagaaaataaagcaaaatcattaccacaaactggtgaagaatcaaataaagat
atgacattaccattaatggcattattagctttaagtagcatcgttgcattcgtattacct
agaaaacgtaaaaac
414.
MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAAEETGGTNTEAQPKTEAVA
SPTTTSEKAPETKPVANAVSVSNKEVEAPTSETKEAKEVKEVKAPKETKEVKPAAKATNN
TYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKKDGTQQFYHYASSVKPARVIFTD
SKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSST
HFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQD
KLPEKLKAEYKKKLEDTKKALDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNE
SMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPY
VEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANTDKSNKKEQQDNSAKKEATPAT
PSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKPTKGEVESSSTT
PTKVVSTTQNVAKPTTASSKTTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNK
NTQENKAKSLPQTGEESNKDMTLPLMALLALSSIVAFVLPRKRKN
415.
atgaattatccaaatggtaaaccatatcgtaaaaatagtgctatagacggagggaaaaag
accgctgcctttagtaatattgagtatggtggacgtggtatgtcacttgaaaaagatatc
gaacattcaaatacgttttatcttaaaagcgacattgcagttattcacaaaaagcctacg
ccagtacaaatagttaatgtcaactatcctaagcggagtaaagctgtgattaacgaagct
tattttcgtacaccttcaacaactgattacaacggcgtttatcaaggttattatattgat
tttgaagcaaaggaaactaaaaacaagacgtcctttcctttaaataatattcatgaccat
caagtcgaacatatgaaaaatgcatatcaacaaaaaggtattgtgtttttaatgattcgt
tttaaaacgctagatgaagtttatcttttaccctattcaaaattcgaagtattttggaag
agatataaagataatattaaaragtctataacagttgatgaaatacgaaaaaatggttac
catattccttatcagtatcaaccaagattagactatctaaaagcagttgataagttgata
ttagatgaaagtgaggaccgcgta
416.
mnypngkpyrknsaidggkktaafsnieyggrgmslekdiehsntfylksdiavihkkpt
pvqivnvnypkrskavineayfrtpsttdyngvyqgyyidfeaketknktsfplnnihdh
qvehmknayqqkgivflmirfktldevyllpyskfevfwkrykdnikxsitvdeirkngy
hipyqyqprldylkavdklildesedrv
417.
ttgatatatctagataatgcggcaacgacgaaagcatttgaagaagtgttagatacttat
ttaaaagtaaatcaatcaatgtattataatccgaatagtccgcataaagctggtttgcag
gcaaatcaattactacaacaagcaaaaacccaaattaatgcaatgattaattcaaaaaca
aattatgatgttgtattcactagtggtgcaactgaatccaataatcttgctttaaaaggt
attgcctatcgtaaatttgatacagcgaaggaaataattacatccgtgttagagcatccg
tccgtattagaggttgtaagatatttggaagcacacgaaggatttaaagttaaatatgtt
gatgtaaagaaagatggcagtattaacttagaacacttcaaagaattaatgtcagacaaa
gtcggtttagtaacatgtatgtatgtaaataatgtaactggacaaatacagcctattcca
caaatggctaaagttataaaaaattatcctaaggcacattttcatgtagatgcggttcaa
gcattcggcaaaatttcaatggatctcaataacatagatagtattagtttaagtggacac
aagtttaatggtttaaaaggacaaggcgtcttacttgtaaatcacattcaaaatgttgaa
ccaactgtccatggtggtggtcaagaatatggcgttagaagtggaacagttaatttgcca
aatgatattgcaatggttaaagcgatgaagatagctaatgaaaactttgaagcattgaat
gcatttgttactgagttaaataatgacgtccgtcaatttttaaataaatatcatggagtt
tatattaattcttcaacttcaggttcaccattcgttttaaatattagttttcctggcgta
aaaggtgaagtattagttaatgctttttcaaaatatgacattatgatatctacgacaagt
gcttgttcatctaaacgtaataaattaaatgaagtattggctgcaatgggattatcagac
aaatctattgaaggtagtataagattatcatttggggctactacaactaaagaagatata
gcgaggtttaaagaaatatttatcatcatttatgaggaaattaaggagttgctaaaa
418.
liyldnaattkafeevldtylkvnqsmyynpnsphkaglqanqllqqaktqinaminskt
nydvvftsgatesnnlalkgiayrkfdtakeiitsvlehpsvlevvryleahegfkvkyv
dvkkdgsinlehfkelmsdkvglvtcmyvnnvtgqiqpipqmakviknypkahfhvdavq
afgkismdlnnidsislsghkfnglkgqgvllvnhiqnveptvhgggqeygvrsgtvnlp
ndiamvkamkianenfealnafvtelnndvrqflnkyhgvyinsstsgspfvlnisfpgv
kgevlvnafskydimisttsacsskrnklnevlaamglsdksiegsirlsfgatttkedi
arfkeifiiiyeeikellk
419.
atgtcatatcattggtttaagaaaatgttactttcaacaagtattttaattttaagtagt
agtagtttagggcttgcaacgcacacagttgaagcaaaggataacttaaatggagaaaaa
ccaactactaatttgaatcataatataacttcaccatcagtaaatagtgaaatgaataat
aatgagactgggacacctcacgaatcaaatcaaacgggtaatgaaggaacaggttcgaat
agtcgtgatgctaatcctgattcgaataatgtgaagccagactcaaacaaccaaaaccca
agtacagattcaaaaccagacccaaataaccaaaacccaagtccgaatcctaaaccagat
ccagataacccgaaaccaaaaccggatccaaaaccagacccagataaaccaaagccaaat
ccggatccaaaaccagatccagataacccgaaaccaaatccagatccaaaaccagaccca
gataaaccaaagccaaatccggatccaaaaccagatccagataaaccaaagccaaatccg
aatccaaaaccagaccctaataagccaaatcctaacccgtcaccagatcccgatcaacct
ggggattccaatcattctggtggctcgaaaaatggggggacatggaacccaaatgcttca
gatggatctaatcaaggtcaatggcaaccaaatgggaatcaaggaaactcacaaaatcct
actggtaatgattttgtatcccaacgatttttagccttggcaaatggggcttacaagtat
aatccgtatattttaaatcaaattaataagttgggcaaagattatggagaagttactgat
gaagacatttataatattattcgaaaacaaaatttcagcggaaatgcatatttaaatgga
ttacaacagcaatcgaattactttagattccaatatttcaatccattgaaatcagaaagg
tactatcgtaatttagatgaacaagtactcgcattaattactggtgaaattggatcaatg
ccagatttgaaaaagcccgaagataagccggattcaaaacaacgctcatttgaaccgcat
gaaaaagacgattttacagtagttaaaaaacaagaagataataagaaaagtgcgtcaact
gcatatagtaaaagttggctagcaattgtatgttctatgatggtggtattttcaatcatg
ctattcttatttgtaaagcgaaataaaaagaaaaataaaaacgaatcacagcgacga
420.
msyhwfkkmllstsililsssslglathtveakdnlngekpttnlnhnitspsvnsemnn
netgtphesnqtgnegtgsnsrdanpdsnnvkpdsnnqnpstdskpdpnnqnpspnpkpd
pdnpkpkpdpkpdpdkpkpnpdpkpdpdnpkpnpdpkpdpdkpkpnpdpkpdpdkpkpnp
npkpdpnkpnpnpspdpdqpgdsnhsggsknggtwnpnasdgsnqgqwqpngnqgnsqnp
tgndfvsqrflalangaykynpyilnqinklgkdygevtdediyniirkqnfsgnaylng
lqqqsnyfrfqyfnplkseryyrnldeqvlalitgeigsmpdlkkpedkpdskqrsfeph
ekddftvvkkqednkksastayskswlaivcsmmvvfsimlflfvkrnkkknknesqrr
421.
atgagagataagaaaggaccggtaaataaaagagtagattttctatcaaataaattgaat
aaatattcaataagaaaatttacagttggaacagcatctattttaattggctcactaatg
tatttgggaactcaacaagaggcagaagcagctgaaaacaatattgagaatccaactaca
ttaaaagataatgtccaatcaaaagaagtgaagattgaagaagtaacaaacaaagacact
gcaccacagggtgtagaagctaaatctgaagtaacttcaaacaaagacacaatcgaacat
gaaccatcagtaaaagctgaagatatatcaaaaaaggaggatacaccaaaagaagtagct
gatgttgctgaagttcagccgaaatcgtcagtcactcataacgcagagacacctaaggtt
agaaaagctcgttctgttgatgaaggctcttttgatattacaagagattctaaaaatgta
gttgaatctaccccaattacaattcaaggtaaagaacattttgaaggttacggaagtgtt
gatatacaaaaaaaaccaacagatttaggggtatcagaggtaaccaggtttaatgttggt
aatgaaagtaatggtttgataggagctttacaattaaaaaataaaatagattttagtaag
gatttcaattttaaagttagagtggcaaataaccatcaatcaaataccacaggtgctgat
ggttgggggttcttatttagtaaaggaaatgcagaagaatatttaactaatggtggaatc
cttggggataaaggtctggtaaattcaggcggatttaaaattgatactggatacatttat
acaagttccatggacaaaactgaaaagcaagctggacaaggttatagaggatacggagct
tttgtgaaaaatgacagttctggtaattcacaaatggttggagaaaatattgataaatca
aaaactaattttttaaactatgcggacaattcaactaatacatcagatggaaagtttcat
gggcaacgtttaaatgatgtcatcttaacttatgttgcttcaactggtaaaatgagagca
gaatatgctggtaaaacttgggagacttcaataacagatttaggtttatctaaaaatcag
gcatataatttcttaattacatctagtcaaagatggggccttaatcaagggataaatgca
aatggctggatgagaactgacttgaaaggttcagagtttacttttacaccagaagcgcca
aaaacaataacagaattagaaaaaaaagttgaagagattccattcaagaaagaacgtaaa
tttaatccggatttagcaccagggacagaaaaagtaacaagagaaggacaaaaaggtgag
aagacaataacgacaccaacactaaaaaatccattaactggagtaattattagtaaaggt
gaaccaaaagaagagattacaaaagatccgattaatgaattaacagaatacggacctgaa
acaatagcgccaggtcatcgagacgaatttgatccgaagttaccaacaggagagaaagag
gaagttccaggtaaaccaggaattaagaatccagaaacaggagacgtagttagaccaccg
gtcgatagcgtaacaaaatatggacctgtaaaaggagactcgattgtagaaaaagaagag
attccattcgagaaagaacgtaaatttaatccggatttagcaccagggacagaaaaagta
acaagagaaggacaaaaaggtgagaagacaataacgacaccaacactaaaaaatccatta
actggagtaattattagtaaaggtgaaccaaaagaagaaatcacaaaagatccgattaat
gaattaacagaatacggaccagaaacgataacaccaggtcatcgagacgaatttgatccg
aagttaccaacaggagagaaagaggaagttccaggtaaaccaggaattaagaatccagaa
acaggagacgtagttagaccaccggtcgatagcgtaacaaaatatggacctgtaaaagga
gactcgattgtagaaaaagaagaaattccattcaagaaagaacgtaaatttaatccggat
ttagcaccagggacagaaaaagtaacaagagaaggacaaaaaggtgagaagacaataacg
acgccaacactaaaaaatccattaactggagaaattattagtaaaggtgaatcgaaagaa
gaaatcacaaaagatccgattaatgaattaacagaatacggaccagaaacgataacacca
ggtcatcgagacgaatttgatccgaagttaccaacaggagagaaagaggaagttccaggt
aaaccaggaattaagaatccagaaacaggagacgtagttagaccaccggtcgatagcgta
acaaaatatggacctgtaaaaggagactcgattgtagaaaaagaagaaattccattcaag
aaagaacgtaaatttaatcctgatttagcaccagggacagaaaaagtaacaagagaagga
caaaaaggtgagaagacaataacgacgccaacactaaaaaatccattaactggagaaatt
attagtaaaggtgaatcgaaagaagaaatcacaaaagatccgattaatgaattaacagaa
tacggaccagaaacgataacaccaggtcatcgagacgaatttgatccgaagttaccaaca
ggagagaaagaggaagttccaggtaaaccaggaattaagaatccagaaacaggagatgta
gttagaccaccggtcgatagcgtaacaaaatatggacctgtaaaaggagactcgattgta
gaaaaagaagaaattccattcgagaaagaacgtaaatttaatcctgatttagcaccaggg
acagaaaaagtaacaagagaaggacaaaaaggtgagaagacaataacgacgccaacacta
aaaaatccattaactggagaaattattagtaaaggtgaatcgaaagaagaaatcacaaaa
gatccagttaatgaattaacagaattcggtggcgagaaaataccgcaaggtcataaagat
atctttgatccaaacttaccaacagatcaaacggaaaaagtaccaggtaaaccaggaatc
aagaatccagacacaggaaaagtgatcgaagagccagtggatgatgtgattaaacacgga
ccaaaaacgggtacaccagaaacaaaaacagtagagataccgtttgaaacaaaacgtgag
tttaatccaaaattacaacctggtgaagagcgagtgaaacaagaaggacaaccaggaagt
aagacaatcacaacaccaatcacagtgaacccattaacaggtgaaaaagttggcgagggt
caaccaacagaagagatcacaaaacaaccagtagataagattgtagagttcggtggagag
aaaccaaaagatccaaaaggacctgaaaacccagagaagccgagcagaccaactcatcca
agtggcccagtaaatcctaacaatccaggattatcgaaagacagagcaaaaccaaatggc
ccagttcattcaatggataaaaatgataaagttaaaaaatctaaaattgctaaagaatca
gtagctaatcaagagaaaaaacgagcagaattaccaaaaacaggtttagaaagcacgcaa
aaaggtttgatctttagtagtataattggaattgctggattaatgttattggctcgtaga
agaaagaat
422.
mrdkkgpvnkrvdflsnklnkysirkftvgtasiligslmylgtqqeaeaaennienptt
lkdnvqskevkieevtnkdtapqgveaksevtsnkdtiehepsvkaediskkedtpkeva
dvaevqpkssvthnaetpkvrkarsvdegsfditrdsknvvestpitiqgkehfegygsv
diqkkptdlgvsevtrfnvgnesngligalqlknkidfskdfnfkvrvannhqsnttgad
gwgflfskgnaeeyltnggilgdkglvnsggfkidtgyiytssmdktekqagqgyrgyga
fvkndssgnsqmvgenidksktnflnyadnstntsdgkfhgqrlndviltyvastgkmra
eyagktwetsitdlglsknqaynflitssqrwglnqginangwmrtdlkgseftftpeap
ktitelekkveeipfkkerkfnpdlapgtekvtregqkgektittptlknpltgviiskg
epkeeitkdpinelteygpetiapghrdefdpklptgekeevpgkpgiknpetgdvvrpp
vdsvtkygpvkgdsivekeeipfekerkfnpdlapgtekvtregqkgektittptlknpl
tgviiskgepkeeitkdpinelteygpetitpghrdefdpklptgekeevpgkpgiknpe
tgdvvrppvdsvtkygpvkgdsivekeeipfkkerkfnpdlapgtekvtregqkgektit
tptlknpltgeiiskgeskeeitkdpinelteygpetitpghrdefdpklptgekeevpg
kpgiknpetgdvvrppvdsvtkygpvkgdsivekeeipfkkerkfnpdlapgtekvtreg
qkgektittptlknpltgeiiskgeskeeitkdpinelteygpetitpghrdefdpklpt
gekeevpgkpgiknpetgdvvrppvdsvtkygpvkgdsivekeeipfekerkfnpdlapg
tekvtregqkgektittptlknpltgeiiskgeskeeitkdpvneltefggekipqghkd
ifdpnlptdqtekvpgkpgiknpdtgkvieepvddvikhgpktgtpetktveipfetkre
fnpklqpgeervkqegqpgsktittpitvnpltgekvgegqpteeitkqpvdkivefgge
kpkdpkgpenpekpsrpthpsgpvnpnnpglskdrakpngpvhsmdkndkvkkskiakes
vanqekkraelpktglestqkglifssiigiaglmllarrrkn
423.
gtgaaaagcaatcttagatacggcataagaaaacacaaattgggagcggcctcagtattc
ttaggaacaatgatcgttgttggaatgggacaagaaaaagaagctgcagcatcggaacaa
aacaatactacagtagaggaaagtgggagttcagctactgaaagtaaagcaagcgaaaca
caaacaactacaaataacgttaatacaatagatgaaacacaatcatacagcgcgacatca
actgagcaaccatcacaatcaacacaagtaacaacagaagaagcaccgaaaactgtgcaa
gcaccaaaagtagaaacttcgcgagttgatttgccatcggaaaaagttgctgataaggaa
actacaggaactcaagttgacatagctcaaccaagtaacgtctcagaaattaaaccaaga
atgaaaagatcaactgacgttacagcagttgcagagaaagaagtagtggaagaaactaaa
gcgacaggtacagatgtaacaaataaagtggaagtagaagaaggtagtgaaattgtagga
cataaacaagatacgaatgttgtaaatcctcataacgcagaaagagtaaccttgaaatat
aaatggaaatttggagaaggaattaaggcgggagattattttgatttcacattaagcgat
aatgttgaaactcatggtatctcaacactgcgtaaagttccggagataaaaagtacagat
ggtcaagttatggcgacaggagaaataattggagaaagaaaagttagatatacgtttaaa
gaatatgtacaagaaaagaaagatttaactgctgaattatctttaaatctatttattgat
cctacaacagtgacgcaaaaaggtaaccaaaatgttgaagttaaattgggtgagactacg
gttagcaaaatatttaatattcaatatttaggtggagttagagataattggggagtaaca
gctaatggtcgaattgatactttaaataaagtagatgggaaatttagtcattttgcgtac
atgaaacctaacaaccagtcgttaagctctgtgacagtaactggtcaagtaactaaagga
aataaaccaggggttaataatccaacagttaaggtatataaacacattggttcagacgat
ttagctgaaagcgtatatgcaaagcttgatgatgtcagcaaatttgaagatgtgactgat
aatatgagtttagattttgatactaatggtggttattctttaaactttaataatttagac
caaagtaaaaattatgtaataaaatatgaagggtattatgattcaaatgctagcaactta
gaatttcaaacacacctttttggatattataactattattatacaagtaatttaacttgg
aaaaatggcgttgcattttactctaataacgctcaaggcgacggcaaagataaactaaag
gaacctattatagaacatagtactcctatcgaacttgaatttaaatcagagccgccagtg
gagaagcatgaattgactggtacaatcgaagaaagtaatgattctaagccaattgatttt
gaatatcatacagctgttgaaggtgcagaaggtcatgcagaaggtaccattgaaactgaa
gaagattctattcatgtagactttgaagaatcgacacatgaaaattcaaaacatcatgct
gatgttgttgaatatgaagaagatacaaacccaggtggtggtcaggttactactgagtct
aacctagttgaatttgacgaagattctacaaaaggtattgtaactggtgctgttagcgat
catacaacaattgaagatacgaaagaatatacgactgaaagtaatctgattgaactagta
gatgaactacctgaagaacatggtcaagcgcaaggaccaatcgaggaaattactgaaaac
aatcatcatatttctcattctggtttaggaactgaaaatggtcacggtaattatggcgtg
attgaagaaatcgaagaaaatagccacgtggatattaagagtgaattaggttacgaaggt
ggccaaaatagcggtaatcagtcatttgaggaagacacagaagaagataaaccgaaatat
gaacaaggtggcaatatcgtagatatcgatttcgatagtgtacctcaaattcatggtcaa
aataatggtaaccaatcattcgaagaagatacagagaaagacaaacctaagtatgaacaa
ggtggtaatatcattgatatcgacttcgacagtgtgccacatattcacggattcaataag
cacactgaaattattgaagaagatacaaataaagataaaccaaattatcaattcggtgga
cacaatagtgttgactttgaagaagatacacttccacaagtaagtggtcataatgaaggt
caacaaacgattgaagaagatacaacacctccaatcgtgccaccaacgccaccgacacca
gaagtaccaagcgagccggaaacaccaacaccaccgacaccagaagtaccaagcgagccg
gaaacaccaacaccgccaacgccagaggtaccaactgaacctggtaaaccaataccacct
gctaaagaagaacctaaaaaaccttctaaaccagtggaacaaggtaaagtagtaacacct
gttattgaaatcaatgaaaaggttaaagcagtggtaccaactaaaaaagcacaatctaag
aaatctgaactacctgaaacaggtggagaagaatcaacaaacaacggcatgttgttcggc
ggattatttagcattttaggtttagcgttattacgcagaaataaaaagaatcacaaagca
424.
vksnlrygirkhklgaasvflgtmivvgmgqekeaaaseqnnttveesgssateskaset
qtttnnvntidetqsysatsteqpsqstqvtteeapktvqapkvetsrvdlpsekvadke
ttgtqvdiaqpsnvseikprmkrstdvtavaekevveetkatgtdvtnkveveegseivg
hkqdtnvvnphnaervtlkykwkfgegikagdyfdftlsdnvethgistlrkvpeikstd
gqvmatgeiigerkvrytfkeyvqekkdltaelslnlfidpttvtqkgnqnvevklgett
vskifniqylggvrdnwgvtangridtlnkvdgkfshfaymkpnnqslssvtvtgqvtkg
nkpgvnnptvkvykhigsddlaesvyaklddvskfedvtdnmsldfdtnggyslnfnnld
qsknyvikyegyydsnasnlefqthlfgyynyyytsnltwkngvafysnnaqgdgkdklk
epiiehstpielefkseppvekheltgtieesndskpidfeyhtavegaeghaegtiete
edsihvdfeesthenskhhadvveyeedtnpgggqvttesnlvefdedstkgivtgavsd
httiedtkeyttesnlielvdelpeehgqaqgpieeitennhhishsglgtenghgnygv
ieeieenshvdikselgyeggqnsgnqsfeedteedkpkyeqggnivdidfdsvpqihgq
nngnqsfeedtekdkpkyeqggniididfdsvphihgfnkhteiieedtnkdkpnyqfgg
hnsvdfeedtlpqvsghnegqqtieedttppivpptpptpevpsepetptpptpevpsep
etptpptpevptepgkpippakeepkkpskpveqgkvvtpvieinekvkavvptkkaqsk
kselpetggeestnngmlfgglfsilglallrrnkknhka
425.
atgaaagctttattacttaaaacaagtgtatggctcgttttgctttttagtgtaatggga
ttatggcaagtctcgaacgcggctgagcagcatacaccaatgaaagcacatgcagtaaca
acgatagacaaagcaacaacagataagcaacaagtaccgccaacaaaggaagcggctcat
cattctggcaaagaagcggcaaccaacgtatcagcatcagcgcagggaacagctgatgat
acaaacagcaaagtaacatccaacgcaccatctaacaaaccatctacagtagtttcaaca
aaagtaaacgaaacacgcgacgtagatacacaacaagcctcaacacaaaaaccaactcac
acagcaacgttcaaattatcaaatgctaaaacagcatcactttcaccacgaatgtttgct
gctaatgcaccacaaacaacaacacataaaatattacatacaaatgatatccatggccga
ctagccgaagaaaaagggcgtgtcatcggtatggctaaattaaaaacagtaaaagaacaa
gaaaagcctgatttaatgttagacgcaggagacgccttccaaggtttaccactttcaaac
cagtctaaaggtgaagaaatggctaaagcaatgaatgcagtaggttatgatgctatggca
gtcggtaaccatgaatttgactttggatacgatcagttgaaaaagttagagggtatgtta
gacttcccgatgctaagtactaacgtttataaagatggaaaacgcgcgtttaagccttca
acgattgtaacaaaaaatggtattcgttatggaattattggtgtaacgacaccagaaaca
aagacgaaaacaagacctgaaggcattaaaggcgttgaatttagagatccattacaaagt
gtgacagcggaaatgatgcgtatttataaagacgtagatacatttgttgttatatcacat
ttaggaattgatccttcaacacaagaaacatggcgtggtgattacttagtgaaacaatta
agtcaaaatccacaattgaagaaacgtattacagttattgatggtcattcacatacagta
cttcaaaatggtcaaatttataacaatgatgcattggcacaaacaggtacagcacttgcg
aatatcggtaagattacatttaattatcgcaatggagaggtatcgaatattaaaccgtca
ttgattaatgttaaagacgttgaaaatgtaacaccgaacaaagcattagctgaacaaatt
aatcaagctgatcaaacatttagagcacaaactgcagaggtaattattccaaacaatacc
attgatttcaaaggagaaagagatgacgttagaacgcgtgaaacaaatttaggaaacgcg
attgcagatgctatggaagcgtatggcgttaagaatttctctaaaaagactgactttgcc
gtgacaaatggtggaggtattcgtgcctctatcgcaaaaggtaaggtgacacgctatgat
ttaatctcagtattaccatttggaaatacgattgcgcaaattgatgtaaaaggttcagac
gtctggacggctttcgaacatagtttaggcgcaccaacaacacaaaaggacggtaagaca
gtgttaacagcgaatggcggtttactacatatctctgattcaatccgtgtttactatgat
ataaataaaccgtctggcaaacgaattaatgctattcaaattttaaataaagagacaggt
aagtttgaaaatattgatttaaaacgtgtatatcacgtaacgatgaatgacttcacagca
tcaggtggcgacggatatagtatgttcggtggtcctagagaagaaggtatttcattagat
caagtactagcaagttatttaaaaacagctaacttagctaagtatgatacgacagaacca
caacgtatgttattaggtaaaccagcagtaagtgaacaaccagctaaaggacaacaaggt
agcaaaggtagtaagtctggtaaagatacacaaccaattggtgacgacaaagtgatggat
ccagcgaaaaaaccagctccaggtaaagttgtattgttgctagcgcatagaggaactgtt
agtagcggtacagaaggttctggtcgcacaatagaaggagctactgtatcaagcaagagt
gggaaacaattggctagaatgtcagtgcctaaaggtagcgcgcatgagaaacagttacca
aaaactggaactaatcaaagttcaagcccagaagcgatgtttgtattattagcaggtata
ggtttaatcgcgactgtacgacgtagaaaagctagc
426.
mkalllktsvwlvllfsvmglwqvsnaaeqhtpmkahavttidkattdkqqvpptkeaah
hsgkeaatnvsasaqgtaddtnskvtsnapsnkpstvvstkvnetrdvdtqqastqkpth
tatfklsnaktaslsprmfaanapqttthkilhtndihgrlaeekgrvigmaklktvkeq
ekpdlmldagdafqglplsnqskgeemakamnavgydamavgnhefdfgydqlkklegml
dfpmlstnvykdgkrafkpstivtkngirygiigvttpetktktrpegikgvefrdplqs
vtaemmriykdvdtfvvishlgidpstqetwrgdylvkqlsqnpqlkkritvidghshtv
lqngqiynndalaqtgtalanigkitfnyrngevsnikpslinvkdvenvtpnkalaeqi
nqadqtfraqtaeviipnntidfkgerddvrtretnlgnaiadameaygvknfskktdfa
vtngggirasiakgkvtrydlisvlpfgntiaqidvkgsdvwtafehslgapttqkdgkt
vltanggllhisdsirvyydinkpsgkrinaiqilnketgkfenidlkrvyhvtmndfta
sggdgysmfggpreegisldqvlasylktanlakydttepqrmllgkpavseqpakgqqg
skgsksgkdtqpigddkvmdpakkpapgkvvlllahrgtvssgtegsgrtiegatvssks
gkqlarmsvpkgsahekqlpktgtnqssspeamfvllagigliatvrrrkas
427.
atgaataaaaattcgaagaagaagctcgattttcttccaaacaagcttaataagtactca
attagacgtttcactgtagggacagcttcgattttagtaggagctactttaattttcggt
gttgcaaatgatcaagcagaagccgctgagaataacacaactcaaaagcaagatgatagt
tcagatgcaagtaaagtaaaaggtaatgttcaaactattgaacaatcttctgcaaattca
aatgaatctgatattcctgaacaagttgatgtaactaaagatacaactgaacaagcatca
acagaagaaaaagcaaatacaactgaacaagcatcaacagaagaaaaagcagatacaact
gaacaagcaacaacagaagaagcgccaaaagctgaaggaacagacaaagtagaaacagaa
gaagcgccaaaagctgaagaaacagacaaagcaacaacagaagaagcgccaaaagctgaa
gaaacagacaaagcaacagaagaagcaccaaaaactgaagaaacagacaaagcaacaaca
gaagaagcgccagcagctgaagaaacaagcaaagcagcaacagaagaagcgccaaaagct
gaagaaacaagcaaagcagcaacagaagaagcgccaaaagctgaagaaacagaaaaaaca
gcaacagaagaagcaccaaaaactgaagaaacagacaaagtagaaacagaagaagcgcca
aaagctgaagaaacaagcaaagcagcaacagaaaaagcaccaaaagctgaagaaacaaac
aaagtagaaacagaagaagcgccagcagctgaagaaacaaacaaagcagcaacagaagaa
acaccagcagttgaagacacaaatgctaagagcaattcaaatgctcaaccatcagaaact
gagagaactcaagttgtagatacagttgctaaagatttatataaaaaatctgaagttaca
gaagcagaaaaagctgaaattgaaaaagtattaccaaaagatatttcaaacttatctaat
gaagaaattaaaaaaatagctttaagtgaagtacttaaagaaacagctaacaaagaaaac
gcacaaccaagagcaacattccgttcagtaagcagcaatgctagaacaacaaatgttaac
tattcagcaacagcattaagagcagctgcacaagacacagttactaaaaaaggaactggt
aactttactgcgcatggagatataatccataaaacttataaagaagaattccctaatgaa
ggcacgctaactgcattcaatacaaacttcaatcctaatacaggaactaaaggcgcatta
gaatataatgataaaatagattttaataaagactttacaattactgttccagtagcaaac
aacaaccaaggtaatacaacaggagcagatggctggggcttcatgtttactcaagggaat
ggccaagacttcttaaaccaaggtggtattttaagagacaaaggtatggcaaatgcatct
ggttttaaaattgatacggcatataataatgttaatggtaaagtcgataaactcgatgca
gataaaacaaacaatctaagtcaaattggcgcagcaaaagttggttacggtacatttgtt
aaaaatggtgcagatggtgtgactaaccaagttggtcaaaatgccctaaatacaaaagat
aaacctgtaaataaaataatttatgcagataatacaactaatcatcttgatggtcaattc
catggccaaagattaaatgatgtagtattaaattatgatgcagcaacaagtacaataact
gctacatatgcaggaaaaacatggaaagctactacagatgatttaggaattgataaatca
caaaaatataatttcttaattacttcaagtcatatgcaaaatagatattctaatggaatt
atgagaacaaatcttgaaggtgtaacaattacaacgcctcaagctgatttaattgatgat
gtggaagtaacgaaacaaccaattcctcataaaactattcgtgagtttgatccaactcta
gaaccaggctcacctgatgttattgtacaaaaaggtgaagatggagagaaaacaacaact
acaccaactaaagttgaccctgatacaggagatgtagttgaacgtggtgaaccaacaaca
gaagttacaaaaaatccagttgacgagattgtacactttacacctgaagaagtaccacaa
ggtcataaagatgagttcgatccaaacttaccaattgacggtacagaagaagtaccaggt
aaaccaggcatcaagaatcctgaaacaggtgaagtagtaacacctccggttgacgatgtc
acaaaacatggtccaaaagcaggcgaaccagaggttactaaagaagaaataccattcgag
aaaaaacgtgagttcaatccagacttaaaaccaggtgaagagaaagtaacgcaagaagga
caaactggagagaaaacaacaacaacgccaacaacaattaatccattaacgggagaaaaa
gtaggcgaaggtgaaccaacaacagaagtaacaaaagaaccagtagatgaaatcacacaa
ttcggtggagaagaagtaccacaaggtcataaagatgagttcgatccaaacttaccaatt
gacggtacagaagaagtaccaggtaaaccaggcatcaagaatcctgaaacaggtgaagta
gtaacacctccggttgacgatgtcacaaaacatggtccaaaagcaggcgaaccagaggtt
actaaagaagaaataccattcgagaaaaaacgtgagttcaatccagacttaaaaccaggt
gaagagaaagtaacgcaagaaggacaaactggagagaaaacaacaacaacgccaacaaca
attaatccattaacgggagaaaaagtaggcgaaggtgaaccaacaacagaagtaacaaaa
gaaccagtagatgaaatcacacaattcggtggagaagaagtaccacaaggtcataaagat
gagttcgatccaaacttaccaattgacggtacagaagaagtaccaggtaaaccaggcatc
aagaatcctgaaacaggtgaagtagtaacacctccggttgacgatgtcacaaaacatggt
ccaaaagcaggcgaaccagaggttactaaagaagaaataccattcgagaaaaaacgtgag
ttcaatccagacttaaaaccaggtgaagagaaagtaacgcaagaaggacaaactggagag
aaaacaacaacaacgccaacaacaattaatccattaacgggagaaaaagtaggcgaaggt
gaaccaacaacagaagtaacaaaagaaccagtagatgaaatcacacaattcggtggagaa
gaagtaccacaaggtcataaagatgagttcgatccaaacttaccaattgacggtacagaa
gaagtaccaggtaaaccaggcatcaagaatcctgaaacaggtgaagtagtaacaccacca
gtagacgatgtcacaaaacatggtccaaaagcaggcgaaccagaggttactaaagaagaa
attccatatgaaactaaacgcgtattagatccaacaatggaaccaggtagtcctgataaa
gtagctcaaaaaggtgaaaatggtgaaaaaacaacaacaacaccaactacaattaatcca
ttaacgggagaaaaagtaggcgaaggcgaaccaacaacggaagtaacgaaagaaccaata
gacgaaattgttaactatgcacctgaaattattcctcatggtacacgtgaagaaattgat
ccaaacttaccagaaggtgaaactaaagttatcccaggtaaagatggcttgaaagatcct
gaaactggagaaatcattgaagaaccacaagatgaagtaatcatccatggtgctaaagat
gattcagatgcggacagcgattcagacgcagatagcgattctgatgcagacagcgactca
gacgcagatagcgactctgatgcggacagcgattcagacagcgatagcgattcagattca
gatagcgactctgatgcggacagcgattcagacagcgatagcgattcagacgcagatagc
gattctgatgcagacagcgactcagacgcagatagcgactcagattcagacgcagatagc
gactcagattcagacgcagatagcgactcagattcagacagcgactcagacgcagacagc
gactcagattcagacagcgattcagacgcagacagcgactcagacgcagatagcgactca
gattcagacagcgattcagacgcagatagcgattcagattcagatagtgactctgatgcg
gacagcgactcagacgcagatagcgactctgatgcggacagcgactcagacgcagatagc
gattctgattcagacagcgattcagacgcagatagcgactcagacgcagatagcgattca
gacgcagatagcgactcagacgcagatagcgattcagattcagatagcgactctgatgcg
gacagcgatagcgattcagattcagacagcgactcagacgcagatagcgactcagacgca
gatagcgatagcgattctgatgcagacagcgactcagacgcagatagcgactctgatgcg
gacggcgactcagacgcagatagcgattctgatgcagacagcgactcagacagcgatagc
gattctgattcagacagcgattcagacgcagatagcgactcagattcagacagcgattca
gacgcagatagagatcataatgacaaaacagataaaccaaataataaagagttaccagat
actggtaatgatgctcaaaataatggcacattatttggttcactattcgctgcgcttgga
ggattattcttagttggcagacgtcgtaaaaacaaaaataatgaagaaaaa
428.
mnknskkkldflpnklnkysirrftvgtasilvgatlifgvandqaeaaennttqkqdds
sdaskvkgnvqtieqssansnesdipeqvdvtkdtteqasteekantteqasteekadtt
eqatteeapkaegtdkveteeapkaeetdkatteeapkaeetdkateeapkteetdkatt
eeapaaeetskaateeapkaeetskaateeapkaeetektateeapkteetdkveteeap
kaeetskaatekapkaeetnkveteeapaaeetnkaateetpavedtnaksnsnaqpset
ertqvvdtvakdlykksevteaekaeiekvlpkdisnlsneeikkialsevlketanken
aqpratfrsvssnarttnvnysatalraaaqdtvtkkgtgnftahgdiihktykeefpne
gtltafntnfnpntgtkgaleyndkidfnkdftitvpvannnqgnttgadgwgfmftqgn
gqdflnqggilrdkgmanasgfkidtaynnvngkvdkldadktnnlsqigaakvgygtfv
kngadgvtnqvgqnalntkdkpvnkiiyadnttnhldgqfhgqrlndvvlnydaatstit
atyagktwkattddlgidksqkynflitsshmqnrysngimrtnlegvtittpqadlidd
vevtkqpiphktirefdptlepgspdvivqkgedgekttttptkvdpdtgdvvergeptt
evtknpvdeivhftpeevpqghkdefdpnlpidgteevpgkpgiknpetgevvtppvddv
tkhgpkagepevtkeeipfekkrefnpdlkpgeekvtqegqtgekttttpttinpltgek
vgegepttevtkepvdeitqfggeevpqghkdefdpnlpidgteevpgkpgiknpetgev
vtppvddvtkhgpkagepevtkeeipfekkrefnpdlkpgeekvtqegqtgekttttptt
inpltgekvgegepttevtkepvdeitqfggeevpqghkdefdpnlpidgteevpgkpgi
knpetgevvtppvddvtkhgpkagepevtkeeipfekkrefnpdlkpgeekvtqegqtge
kttttpttinpltgekvgegepttevtkepvdeitqfggeevpqghkdefdpnlpidgte
evpgkpgiknpetgevvtppvddvtkhgpkagepevtkeeipyetkrvldptmepgspdk
vaqkgengekttttpttinpltgekvgegepttevtkepideivnyapeiiphgtreeid
pnlpegetkvipgkdglkdpetgeiieepqdeviihgakddsdadsdsdadsdsdadsds
dadsdsdadsdsdsdsdsdsdsdsdadsdsdsdsdsdadsdsdadsdsdadsdsdsdads
dsdsdadsdsdsdsdsdadsdsdsdsdsdadsdsdadsdsdsdsdsdadsdsdsdsdsda
dsdsdadsdsdadsdsdadsdsdsdsdsdadsdsdadsdsdadsdsdadsdsdsdsdsda
dsdsdsdsdsdsdadsdsdadsdsdsdadsdsdadsdsdadgdsdadsdsdadsdsdsds
dsdsdsdsdadsdsdsdsdsdadrdhndktdkpnnkelpdtgndaqnngtlfgslfaalg
glflvgrrrknknneek
429.
ttgaaaaagaaaaacatttattcaattcgtaaactaggtgtaggtattgcatctgtaact
ttaggtacattacttatatctggtggcgtaacacctgctgcaaatgctgcgcaacacgat
gaagctcaacaaaatgctttttatcaagtcttaaatatgcctaacttaaatgctgatcaa
cgcaatggttttatccaaagccttaaagatgatccaagccaaagtgctaacgttttaggt
gaagctcaaaaacttaatgactctcaagctccaaaagctgatgcgcaacaaaataacttc
aacaaagatcaacaaagcgccttctatgaaatcttgaacatgcctaacttaaacgaagcg
caacgtaacggcttcattcaaagtcttaaagacgacccaagccaaagcactaacgtttta
ggtgaagctaaaaaattaaacgaatctcaagcaccgaaagctgataacaatttcaacaaa
gaacaacaaaatgctttctatgaaatcttgaatatgcctaacttaaacgaagaacaacgc
aatggtttcatccaaagcttaaaagatgacccaagccaaagtgctaacctattgtcagaa
gctaaaaagttaaatgaatctcaagcaccgaaagcggataacaaattcaacaaagaacaa
caaaatgctttctatgaaatcttacatttacctaacttaaacgaagaacaacgcaatggt
ttcatccaaagcctaaaagatgacccaagccaaagcgctaaccttttagcagaagctaaa
aagctaaatgatgctcaagcaccaaaagctgacaacaaattcaacaaagaacaacaaaat
gctttctatgaaattttacatttacctaacttaactgaagaacaacgtaacggcttcatc
caaagccttaaagacgatccttcagtgagcaaagaaattttagcagaagctaaaaagcta
aacgatgctcaagcaccaaaagaggaagacaataacaagcctggcaaagaagacaataac
aagcctggcaaagaagacaacaacaagcctggtaaagaagacaacaacaagcctggcaaa
gaagacggcaacaagcctggtaaagaagacaacaaaaaacctggtaaagaagatggcaac
aagcctggtaaagaagacaacaaaaaacctggtaaagaagacggcaacaagcctggcaaa
gaagatggcaacaaacctggtaaagaagatggtaacggagtacatgtcgttaaacctggt
gatacagtaaatgacattgcaaaagcaaacggcactactgctgacaaaattgctgcagat
aacaaattagctgataaaaacatgatcaaacctggtcaagaacttgttgttgataagaag
caaccagcaaaccatgcagatgctaacaaagctcaagcattaccagaaactggtgaagaa
aatccattcatcggtacaactgtatttggtggattatcattagccttaggtgcagcgtta
ttagctggacgtcgtcgcgaacta
430.
lkkkniysirklgvgiasvtlgtllisggvtpaanaaqhdeaqqnafyqvlnmpnlnadq
rngfiqslkddpsqsanvlgeaqklndsqapkadaqqnnfnkdqqsafyeilnmpnlnea
qrngfiqslkddpsqstnvlgeakklnesqapkadnnfnkeqqnafyeilnmpnlneeqr
ngfiqslkddpsqsanllseakklnesqapkadnkfnkeqqnafyeilhlpnlneeqrng
fiqslkddpsqsanllaeakklndaqapkadnkfnkeqqnafyeilhlpnlteeqrngfi
qslkddpsvskeilaeakklndaqapkeednnkpgkednnkpgkednnkpgkednnkpgk
edgnkpgkednkkpgkedgnkpgkednkkpgkedgnkpgkedgnkpgkedgngvhvvkpg
dtvndiakangttadkiaadnkladknmikpgqelvvdkkqpanhadankaqalpetgee
npfigttvfgglslalgaallagrrrel
431.
atgaagaaaacaattttactgacgatgacaactcttactttatttagtatgtcgcctaac
tcggctcaagcatatacgaatgatagcaaaacattagaagaagcaaagaaagcacaccca
aacgcacagttcaaagtgaataaagacaccggcgcgtatacttatacatatgacaaaaac
aacacgccaaacaacaatcatcaaaaccagtcacgtacaaacgacaatcatcaacacgca
aatcaacgtgatcttaacaacaatcagtaccattcttcattaagtggtcagtatacgcac
attaatgacgcaattgattcacacacaccgcctcaaacgtcaccaagcaatcctttgaca
ccagcaataccgaatgtcgaagacaatgacgatgaattaaataacgctttttcaaaagat
aacaaagggcttattacaggcatcgatttagacgaattgtatgacgaattacaaatcgcc
gaatttaatgacaaagcaaagaccgctgacggtaaacctttagcattaggtaacggtaaa
atcattgatcagcctcttatcacaagtaagaacaacttatatactgctggacaatgtaca
tggtatgtctttgataaacgtgccaaagatggacacacgattagtacattttggggagat
gctaaaaactgggcaggccaagcttcaagcaatggcttcaaagtagatagacacccaaca
cgaggatcaattttacaaacagtaaatggtccatttggtcatgtagcctacgttgaaaaa
gttaatattgatggaagtattctaatttcagaaatgaactggattggtgaatatatcgtt
tcatcaagaaccatctctgcttcagaagtttcatcatataattacatccat
432.
mkktilltmttltlfsmspnsaqaytndsktleeakkahpnaqfkvnkdtgaytytydkn
ntpnnnhqnqsrtndnhqhanqrdlnnnqyhsslsgqythindaidshtppqtspsnplt
paipnvednddelnnafskdnkglitgidldelydelqiaefndkaktadgkplalgngk
iidqplitsknnlytagqctwyvfdkrakdghtistfwgdaknwagqassngfkvdrhpt
rgsilqtvngpfghvayvekvnidgsilisemnwigeyivssrtisasevssynyih
433.
atgaatcaatatcattctaatgcacaacaaccaagtgcatggcgtttttttgtctatagt
ttagtgggcatactatgtttctttattccttttacgattaatggtaacaacactattttc
gtcgatcatgttcatctagccattcgctcaatcataggtccacttatgccctatgttgca
ctgattatgattttaattggtacagcgttaccaatagtgagacgtacttttatgacttca
atcacaaacttggtcattacattatttaaagttgcaggtgcaatgatcggtataatgtat
gtatttaaaatcggtccatcaatactatttaaagctaactatggtccgtttttgtttgaa
aaattaatgatgccattaagtatcttaattccagtaggtgcaattgcgctttctttatta
gtgggctatggcttattagaatttgtcggtgtttatatggagcctattatgagacctatt
tttaaaacaccaggaaaatccgctgtcgatgcagtggcttcgtttgtcggcagttattcc
ttaggattattgattactaatcgtgtctataagcaagggatgtacaacaaacgagaagcc
acgattattgcgactggcttttcaacagtttcagcaacttttatgattatcgttgctaaa
actttaggattaatgccgcattggaatttatacttttggataactttagtcatcacattt
gtcgtgactgcaattactgcatggctaccgccaatcagcaatgaatcaacagaatattat
aacggacaagaaggagaacaagaagttgctattgaaggaagcagactgaaaactgcatat
gcagaggcgatgaaacaaaatgcattaacaccatctctcgtgaagaacgtttgggacaat
ttgaaagacggtttagaaatgactgttggtattttaccttctatattatcgattggtttt
ttaggactgattgtagcgaactatacaccattcattgattggcttggctatatcttctat
ccatttatttatattttcccaattgctgatcaggctttactagcaaaagcgtcagcgatt
tctattgtagagatgtttctaccatctttgttagtaactaaagctgcaatgagtactaaa
tttgtcgtcggtgtagtaagcgtatcagccattatctttttctcagcattagtgccatgt
atactagcaactgaaattaaaatacctgtctggaaactcatcatcatttggtttttacgc
gtggcgttgtcgctattaatcaccatccccgtcgctttacttatttttgga
434.
mnqyhsnaqqpsawrffvyslvgilcffipftingnntifvdhvhlairsiigplmpyva
limiligtalpivrrtfmtsitnlvitlfkvagamigimyvfkigpsilfkanygpflfe
klmmplsilipvgaialsllvgygllefvgvymepimrpifktpgksavdavasfvgsys
lgllitnrvykqgmynkreatiiatgfstvsatfmiivaktlglmphwnlyfwitlvitf
vvtaitawlppisnesteyyngqegeqevaiegsrlktayaeamkqnaltpslvknvwdn
lkdglemtvgilpsilsigflglivanytpfidwlgyifypfiyifpiadqallakasai
sivemflpsllvtkaamstkfvvgvvsvsaiiffsalvpcilateikipvwkliiiwflr
valsllitipvallifg
435.
atgaaaatgagaacaattgctaaaaccagtttagcactagggcttttaacaacaggcgca
attacagtaacgacgcaatcggtcaaagcagaaaaaatacaatcaactaaagttgacaaa
gtaccaacgcttaaagcagagcgattagcaatgataaacataacagcaggtgcaaattca
gcgacaacacaagcagctaacacaagacaagaacgcacgcctaaactcgaaaaggcacca
aatactaatgaggaaaaaacctcagcttccaaaatagaaaaaatatcacaacctaaacaa
gaagagcagaaaacgcttaatatatcagcaacgccagcgcctaaacaagaacaatcacaa
acgacaaccgaatccacaacgccgaaaactaaagtgacaacacctccatcaacaaacacg
ccacaaccaatgcaatctactaaatcagacacaccacaatctccaaccataaaacaagca
caaacagatatgactcctaaatatgaagatttaagagcgtattatacaaaaccgagtttt
gaatttgaaaagcagtttggatttatgctcaaaccatggacgacggttaggtttatgaat
gttattccaaataggttcatctataaaatagctttagttggaaaagatgagaaaaaatat
aaagatggaccttacgataatatcgatgtatttatcgttttagaagacaataaatatcaa
ttgaaaaaatattctgtcggtggcatcacgaagactaatagtaaaaaagttaatcacaaa
gtagaattaagcattactaaaaaagataatcaaggtatgatttcacgcgatgtttcagaa
tacatgattactaaggaagagatttccttgaaagagcttgattttaaattgagaaaacaa
cttattgaaaaacataatctttacggtaacatgggttcaggaacaatcgttattaaaatg
aaaaacggtgggaaatatacgtttgaattacacaaaaaactgcaagagcatcgtatggca
ggcactaatattgataacattgaagtgaatataaaa
436.
mkmrtiaktslalgllttgaitvttqsvkaekiqstkvdkvptlkaerlaminitagans
attqaantrqertpklekapntneektsaskiekisqpkqeeqktlnisatpapkqeqsq
tttesttpktkvttppstntpqpmqstksdtpqsptikqaqtdmtpkyedlrayytkpsf
efekqfgfmlkpwttvrfmnvipnrfiykialvgkdekkykdgpydnidvfivlednkyq
lkkysvggitktnskkvnhkvelsitkkdnqgmisrdvseymitkeeislkeldfklrkq
liekhnlygnmgsgtivikmknggkytfelhkklqehrmagtnidnievnik
437.
atgaaaataacaacgattgctaaaacaagtttagcactaggccttttaacaacaggtgta
atcacaacgacaacgcaagcagcaaacgcgacaacaccatcttccactaaagtggaagca
ccacaatcaacaccgccctcaactaaaatagaagcaccgcaatcaaaaccaaacgcgaca
acaccgccctcaactaaagtagaagcaccgcaacaaacagcaaatgcgacaacaccgcct
tcaactaaagtgacaacacctccatcaacaaacacgccacaaccaatgcaatctactaaa
tcagacacaccacaatcgccaaccacaaaacaagtaccaacagaaataaatcctaaattt
aaagatttaagagcgtattatacgaaaccaagtttagaatttaaaaatgagattggtatt
attttaaaaaaatggacgacaataagatttatgaatgttgtcccagattatttcatatat
aaaattgctttagttggtaaagatgataaaaaatatggtgaaggagtacataggaatgtc
gatgtatttgtcgttttagaagaaaataattacaatctggaaaaatattctgtcggtggt
atcacaaagagtaatagtaaaaaagttgatcacaaagcaggagtaagaattactaaggaa
gataataaaggtacaatctctcatgatgtttcagaattcaagattactaaagaacagatt
tccttgaaagaacttgattttaaattgagaaaacaacttattgaaaaaaataatctgtac
ggtaacgttggttcaggtaaaattgttattaaaatgaaaaacggtggaaagtacacgttt
gaattgcacaaaaaattacaagaaaatcgcatggcagatgtcattaatagtgaacaaatt
aaaaacatcgaagtgaatttgaaa
438.
mkittiaktslalgllttgvittttqaanattpsstkveapqstppstkieapqskpnat
tppstkveapqqtanattppstkvttppstntpqpmqstksdtpqspttkqvpteinpkf
kdlrayytkpslefkneigiilkkwttirfmnvvpdyfiykialvgkddkkygegvhrnv
dvfvvleennynlekysvggitksnskkvdhkagvritkednkgtishdvsefkitkeqi
slkeldfklrkqlieknnlygnvgsgkivikmknggkytfelhkklqenrmadvinseqi
knievnlk
439.
gtgaattatcgtgataaaattcaaaagtttagtattcgtaaatatacagttggtacattt
tcaactgtcattgcgacattggtatttttaggattcaatacatcacaagcacatgctgct
gaaacaaatcaaccagcaagcgtggttaaacagaaacaacaaagtaataatgaacagact
gagaatcgagaatctcaagtacaaaattctcaaaattcacaaaatggtcaatcattatct
gctactcatgaaaatgagcaaccaaatattagtcaagctaatttagtagatcaaaaagta
gcgcaatcatctactactaatgatgaacaaccagcatctcaaaatgtaaatacaaagaaa
gattcggcaacggctgcgacaacacaaccagataaagaacaaagtaagcataaacaaaac
gaaagtcaatctgctaataaaaatggaaacgacaatagagcggctcatgtagaaaatcat
gaagcaaatgtagtaacagcttcagattcatctgataatggtaacgtacaacatgaccga
aatgaattacaagcgttttttgatgcaaattatcatgattatcgctttattgaccgtgaa
aatgcagattctggcacatttaactatgtaaaaggcatttttgataagattaatacgtta
ttaggcagtaatgatccaataaacaataaagacttgcaacttgcatacaaagaattggaa
caagctgttgctttaattcgtacaatgcctcaacgtcaacagactagccgacgttcaaat
agaattcaaacgcgttcggttgagtcaagagctgcagagcctagatcagtatcagactat
caaaatgcaaattcatcatattatgttgaaaatgctaatgatggttcgggctatcctgtt
ggtacatatatcaatgcttctagtaaaggggcgccatataatttaccaactacaccatgg
aatacattgaaggcctctgactcaaaggaaattgctcttatgacagcgaaacaaactgga
gacgggtaccaatgggttattaagtttaataaaggacatgctccacatcaaaatatgatc
ttttggtttgcattaccagcagaccaagtgccagtaggaagaactgactttgtaacagtt
aattcagatggaacaaatgtacaatggagtcatggagcaggagcaggtgcaaataaacca
cttcaacaaatgtgggaatatggagtaaatgatcctcatcgttcacatgactttaaaata
agaaatagaagtggccaagtaatatatgactggccaactgtccatatttattctttagaa
gatttatctagagcgagtgattattttagtgaagctggagcgacacctgctactaaagct
tttggtagacaaaattttgaatatattaatggtcaaaaacctgctgaatcaccgggtgtt
cctaaagtttatactttcatcggtcaaggtgatgcaagttatacaatttcatttaaaaca
caaggtccaactgttaataaattgtactatgcagcaggtgggcgtgctttagagtacaat
caattatttatgtacagtcaactatacgtcgaatcaacgcaagaccatcaacaacgtctt
aatggtttaagacaagtggttaatcgtacatatcgcataggtacaactaaacgtgtagaa
gtgagtcaaggaaatgtacaaacgaaaaaggtattagaaagtacaaacctaaatatagat
gattttgttgatgatcctttaagttatgttaagacgccgagtaataaagtgttaggattt
tattcgaataatgcaaatactaatgcttttagaccgggtggagcccaacaattaaatgaa
tatcaattaagtcaattatttactgatcaaaaattacaagaagcagcaagaactagaaac
ccaataagattaatgattggtttcgactatcctgatgcttatggtaatagtgaaacttta
gttcctgttaacttaacggtattacctgaaatccaacataatattaaattctttaaaaat
gacgatactcaaaatattgctgaaaaaccattttcaaaacaagctgggcatccagttttc
tatgtatatgcaggtaaccaagggaatgcttccgtgaatttaggtggtagcgtaacatct
attcaaccattacgtattaatttaacaagtaatgagaattttacagataaagattggcaa
attacaggtattccgcgtacattacacattgaaaactcgacaaatagacctaataatgcc
agagaacgcaatattgaacttgttggtaacttattaccaggggattactttggaacgata
cgttttggacgtaaagaacaattattcgaaattcgtgttaaaccacatacaccaacaatt
acaacgacagctgagcaattaagaggtacagcattacaaaaagtgcctgttaatatttcg
ggaataccgttggatccatcggcattggtttatttagttgcaccaacaaatcaaactacg
aatggtggtagtgaggcagatcaaataccatctggttatacgatacttgcgactggtaca
cctgatggggtgcataatacaattactatacgaccgcaagattatgttgtattcatacca
cctgtaggtaaacaaattagagcagtagtttattataataaagtagttgcatctaatatg
agtaatgctgttactattttgccagatgacattccaccaacaatcaataatcctgttgga
ataaatgccaaatactatcgaggcgacgaagtcaactttacaatgggtgtctctgataga
cattctggtataaaaaatacaactattacgacattgccgaatggttggacatcaaattta
acaaaagcggataagaataatggctcattatctattacaggtagagtgagtatgaatcag
gcatttaacagtgatattacatttaaagtgtcagcgacagacaatgtcaataatacgaca
aatgatagtcaatctaaacatgtttcaattcatgtaggtaaaattagtgaagatgctcat
ccgattgtattaggaaatactgagaaagttgtagtagtcaatccgactgctgtatctaat
gatgaaaagcaaagcataattactgcctttatgaataaaaaccaaaatataagaggatat
ttagcatcaactgatccagtaactgtcgataataatggtaatgtcacattacattaccgt
gatggctcatcgacaacgcttgatgctacaaatgtgatgacatacgaaccagttgtgaaa
cctgaataccaaactgtcaatgctgctaaaacagcaacggtaacgattgctaaaggacaa
tcatttagtattggtgatattaaacaatattttactttaagtaatggacaacctattcca
agtggcacatttacaaatattacatctgatagaactattccaactgcacaagaagttagt
caaatgaacgcaggcacgcagttataccatataactgctacaaatgcgtatcataaagat
agtgaagacttctatattagtttgaaaatcatcgatgtgaaacaaccagaaggcgatcaa
cgtgtatatcgtacatcaacatatgatttaactactgatgaaatctcaaaagtaaaacaa
gcatttattaatgcaaatagagatgtaattacgcttgccgaaggtgatatttcagttaca
aatacacctaatggtgctaatgtaagtactattacagtaaatattaataaaggtcgatta
acgaaatcattcgcgtcaaacctagctaatatgaatttcttgcgttgggttaatttccca
caagattatacagtgacatggacgaatgcaaaaattgcaaacagaccaacagatggtggt
ttatcatggtctgatgaccataaatctttaatttatcgttatgatgctacattaggtact
caaattacgacgaatgatattttaacaatgttaaaagcaacaactacagtgcctggattg
cgaaataacattactggtaatgaaaaatcacaagcagaagctggcggaagacctaacttt
agaacgactggttattcacaatcaaatgcgacaactgatggtcaacgtcaatttacgttg
aatggtcaagtgattcaagtgttagacatcatcaacccttcaaacggttatggtgggcaa
cctgttacaaattcaaatactcgtgcaaaccatagtaactcaactgttgttaacgtaaac
gaaccggcagctaatggtgctggcgcatttacaattgaccacgttgtaaaaagtaattct
acacataatgcaagtgatgcagtttataaagcacagttatacttaacgccatatggtcca
aaacaatatgttgaacatttaaatcaaaatacaggaaatactactgacgctattaacatt
tattttgtaccaagtgacttagtgaatccaacaatttcagtaggtaattacactaatcat
caagtgttctcaggtgaaacatttacaaatactattacagcgaatgataactttggtgtg
caatctgtaactgtaccaaatacatcacaaattacaggtactgttgataataaccatcaa
catgtttctgcaacggcaccaaatgtgacatcagcaactaataagacaatcaatttatta
gcaactgatacaagcggcaatacagctacaacttcgttcaatgtaacagtgaaacctttg
cgtgataaatatcgagttggtacttcatcaacggctgctaatcctgtgagaattgccaat
atttcgaataatgcgacagtatcacaagctgatcaaacgacaattattaattcgttaacg
tttactgaaacagtaccaaatagaagttatgcaagagcaagtgcgaatgaaatcactagt
aaaacagttagtaatgtcagtcgtactggaaataatgccaatgtcacagtaactgttact
tatcaagatggaacaacatcaacagtgactgtacctgtaaagcatgtcattccagaaatc
gttgcacattcgcattacactgtacaaggccaagacttcccagcaggtaatggttctagt
gcatcagattactttaagttatctaatggtagtgacattgcagatgcaactattacatgg
gtaagtggacaagcgccaaataaagataatacacgtattggtgaagatataactgtaact
gcacatatcttaattgatggcgaaacaacgccgattacgaaaacagcaacatataaagta
gtaagaactgtaccgaaacatgtctttgaaacagccagaggtgttttatacccaggtgtt
tcagatatgtatgatgcgaaacaatatgttaagccagtaaataattcttggtcgacaaat
gcgcaacatatgaatttccaatttgttggaacatatggtcctaacaaagatgttgtaggc
atatctactcgtcttattagagtgacatatgataatagacaaacagaagatttaactatt
ttatctaaagttaaacctgacccacctagaattgacgcaaactctgtgacatataaagca
ggtcttacaaaccaagaaattaaagttaataacgtattaaataactcgtcagtaaaatta
tttaaagcagataatacaccattaaatgtcacaaatattactcatggtagcggttttagt
tcggttgtgacagtaagtgacgcgttaccaaatggcggaattaaagcaaaatcttcaatt
tcaatgaacaatgtgacgtatacgacgcaagacgaacatggtcaagttgttacagtaaca
agaaatgaatctgttgattcaaatgacagtgcaacagtaacagtgacaccacaattacaa
gcaactactgaaggcgctgtatttattaaaggtggcgacggttttgatttcggacacgta
gaaagatttattcaaaacccgccacatggggcaacggttgcatggcatgatagtccagat
acatggaagaatacagtcggtaacactcataaaactgcggttgtaacattacctaatggt
caaggtacgcgtaatgttgaagttccagtcaaagtttatccagttgctaatgcaaaggcg
ccatcacgtgatgtgaaaggtcaaaatttgactaatggaacggatgcgatgaactacatt
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ccaaataaccaacaagcaggcgtgcaacatttaaatgtcgatgtcacatatccaggtatt
tcagctgctaaacgagttcctgttactgttaatgtatatcaatttgaattccctcaaact
acttatacgacaacggttggaggcactttagcaagtggtacgcaagcatcaggatatgca
catatgcaaaatgctactggtttaccaacagatggatttacgtataaatggaatcgtgat
actacaggtacaaatgacgcaaactggtcagctatgaataaaccgaatgtggctaaagtc
gttaacgcaaaatatgacgtcatctataacggacatacttttgcaacatctttaccagcg
aaatttgtagtaaaagatgtgcaaccagcgaaaccaactgtgactgaaacagcggcagga
gcgattacaattgcacctggagcaaaccaaacagtgaatacacatgccggtaacgtaacg
acatacgctgataaattagttattaaacgtaatggtaacgttgtgacgacatttacacgt
cgcaataatacgagtccatgggtgaaagaagcatctgcagcaactgtagcaggtattgct
ggaactaataatggtattactgttgcagcaggtactttcaaccctgctgatacaattcaa
gttgttgcaacgcaaggaagcggagagacagtgagtgatgagcaacgtagtgatgatttc
acagttgtcgcaccacaaccgaaccaagcgactactaagatttggcaaaatggtcatatt
gatatcacgcctaataatccatcaggacatttaattaatccaactcaagcaatggatatt
gcttacactgaaaaagtgggtaatggtgcagaacatagtaagacaattaatgttgttcgt
ggtcaaaataatcaatggacaattgcgaataagcctgactatgtaacgttagatgcacaa
actggtaaagtgacgttcaatgccaatactataaaaccaaattcatcaatcacaattact
ccgaaagcaggtacaggtcactcagtaagtagtaatccaagtacattaactgcaccggca
gctcatactgtcaacacaactgaaattgtgaaagattatggttcaaatgtaacagcagct
gaaattaacaatgcagttcaagttgctaataaacgtactgcaacgattaaaaatggcaca
gcaatgcctactaatttagctggtggtagcacaacgacgattcctgtgacagtaacttac
aatgatggtagtactgaagaagtacaagagtccattttcacaaaagcggataaacgtgag
ttaatcacagctaaaaatcatttagatgatccagtaagcactgaaggtaaaaagccaggt
acaattacgcagtacaataatgcaatgcataatgcgcaacaacaaatcaatactgcgaaa
acagaagcacaacaagtgattaataatgagcgtgcaacaccacaacaagtttctgacgca
ctaactaaagttcgtgcagcacaaactaagattgatcaagctaaagcattacttcaaaat
aaagaagataatagccaattagtaacgtctaaaaataacttacaaagttctgtgaaccaa
gtaccatcaactgctggtatgacgcaacaaagtattgataactataatgcgaagaagcgt
gaagcagaaactgaaataactgcagctcaacgtgttattgacaatggcgatgcaactgca
caacaaatttcagatgaaaaacatcgtgtcgataacgcattaacagcattaaaccaagcg
aaacatgatttaactgcagatacacatgccttagagcaagcagtgcaacaattgaatcgc
acaggtacaacgactggtaagaagccggcaagtattactgcttacaataattcgattcgt
gcacttcaaagtgacttaacaagtgctaaaaatagcgctaatgctattattcaaaagcca
ataagaacagtacaagaagtgcaatctgcgttaacaaatgtaaatcgtgtcaatgagcga
ttaacgcaagcaattaatcaattagtacctttagctgataatagtgctttaaaaactgct
aagacgaaacttgatgaagaaatcaataaatcagtaactactgatggtatgacacaatca
tcaatccaagcatatgaaaatgctaaacgtgcgggtcaaacagaatcaacaaatgcacaa
aatgttattaacaatggtgatgcgactgaccaacaaattgccgcagaaaaaacaaaagta
gaagaaaaatataatagcttaaaacaagcaattgctggattaactccagacttggcacca
ttacaaactgcaaaaactcagttgcaaaatgatattgatcagccaacgagtacgactggt
atgacaagcgcatctattgcagcatttaatgaaaaactttcagcagctagaactaaaatt
caagaaattgatcgtgtattagcctcacatccagatgttgcgacaatacgtcaaaacgtg
acagcagcgaatgccgctaaatcagcacttgatcaagcacgtaatggcttaacagtcgat
aaagcgcctttagaaaatgcgaaaaatcaactacaatatagtattgacacgcaaacaagt
acaactggtatgacacaagactctataaatgcatacaatgcgaagttaacagctgcacgt
aataagattcaacaaatcaatcaagtattagcaggttcaccgactgtagaacaaattaat
acaaatacgtctacagcaaatcaagctaaatctgatttagatcatgcacgtcaagcttta
acaccagataaagcgccgcttcaaactgcgaaaacgcaattagaacaaagcattaatcaa
ccaacggatacaacaggtatgacgaccgcttcgttaaatgcgtacaaccaaaaattacaa
gcagcgcgtcaaaagttaactgaaattaatcaagtgttgaatggcaacccaactgtccaa
aatatcaatgataaagtgacagaggcaaaccaagctaaggatcaattaaatacagcacgt
caaggtttaacattagatagacagccagcgttaacaacattacatggtgcatctaactta
aaccaagcacaacaaaataatttcacgcaacaaattaatgctgctcaaaatcatgctgcg
cttgaaacaattaagtctaacattacggctttaaatactgcgatgacgaaattaaaagac
agtgttgcggataataatacaattaaatcagatcaaaattacactgacgcaacaccagct
aataaacaagcgtatgataatgcagttaatgcggctaaaggtgtcattggagaaacgact
aatccaacgatggatgttaacacagtgaaccaaaaagcagcatctgttaaatcgacgaaa
gatgctttagatggtcaacaaaacttacaacgtgcgaaaacagaagcaacaaatgcgatt
acgcatgcaagtgatttaaaccaagcacaaaagaatgcattaacacaacaagtgaatagt
gcacaaaacgtgcaagcagtaaatgatattaaacaaacgactcaaagcttaaatactgct
atgacaggtttaaaacgtggcgttgctaatcataaccaagtcgtacaaagtgataattat
gtcaacgcagatactaataagaaaaatgattacaacaatgcatacaaccatgcgaatgac
attattaatggtaatgcacaacatccagttataacaccaagtgatgttaacaatgcttta
tcaaatgtcacaagtaaagaacatgcattgaatggtgaagctaagttaaatgctgcgaaa
caagaagcgaatactgcattaggtcatttaaacaatttaaataatgcacaacgtcaaaac
ttacaatcgcaaattaatggtgcgcatcaaattgatgcagttaatacaattaagcaaaat
gcaacaaacttgaatagtgcaatgggtaacttaagacaagctgttgcagataaagatcaa
gtgaaacgtacagaagattatgcggatgcagatacagctaaacaaaatgcatataacagt
gcagtttcaagtgccgaaacaatcattaatcaaacaacaaatccaacgatgtctgttgat
gatgttaatcgtgcaacttcagctgttacttctaataaaaatgcattaaatggttatgaa
aaattagcacaatctaaaacagatgctgcaagagcaattgatgcattaccacatttaaat
aatgcacaaaaagcagatgttaaatctaaaattaatgctgcatcaaatattgctggcgta
aatactgttaaacaacaaggtacagatttaaatacagcgatgggtaacttgcaaggtgca
atcaatgatgaacaaacgacgcttaatagtcaaaactatcaagatgcgacacctagtaag
aaaacagcatacacaaatgcggtacaagctgcgaaagatattttaaataaatcaaatggt
caaaataaaacgaaagatcaagttactgaagcgatgaatcaagtgaattctgctaaaaat
aacttagatggtacgcgtttattagatcaagcgaagcaaacagcaaaacagcagttaaat
aatatgacgcatttaacaactgcacaaaaaacgaatttaacaaaccaaattaatagtggt
actactgtcgctggtgttcaaacggttcaatcaaatgccaatacattagatcaagccatg
aatacgttaagacaaagtattgccaacaaagatgcgactaaagcaagtgaagattacgta
gatgctaataatgataagcaaacagcatataacaacgcagtagctgctgctgaaacgatt
attaatgctaatagtaatccagaaatgaatccaagtacgattacacaaaaagcagagcaa
gtgaatagttctaaaacggcacttaacggtgatgaaaacttagctgctgcaaaacaaaat
gcgaaaacgtacttaaacacattgacaagtattacagatgctcaaaagaacaatttgatt
agtcaaattactagtgcgacaagagtgagtggtgttgatactgtaaaacaaaatgcgcaa
catctagaccaagctatggctagcttacagaatggtattaacaacgaatctcaagtgaaa
tcatctgagaaatatcgtgatgctgatacaaataaacaacaagagtatgataatgctatt
actgcagcgaaagcgattttaaataaatcgacaggtccaaacactgcgcaaaatgcagtt
gaagcagcattacaacgtgttaataatgcgaaagatgcattgaatggtgatgcaaaatta
attgcagctcaaaacgcagcgaaacaacatttaggtactttaacgcatatcactacagct
caacgtaatgatttaacaaatcaaatttcacaagctacaaacttagctggtgttgaatct
gttaaacaaaatgcgaatagtttagatggtgctatgggtaacttacaaacggctatcaac
gataagtcaggaacattagcgagccaaaacttcttggatgctgatgagcaaaaacgtaat
gcatacaatcaagctgtatcagcagccgaaaccattttaaataaacaaactggaccgaat
acagcgaaaacagcagtcgaacaagcacttaataatgttaataatgcgaaacatgcatta
aatggtacgcaaaacttaaacaatgcgaaacaagcagcgattacagcaatcaatggcgca
tctgatttaaatcaaaaacaaaaagatgcattaaaagcacaagctaatggtgctcaacgc
gtatctaatgcacaagatgtacagcacaatgcgactgaactgaacacggcaatgggcaca
ttaaaacatgccatcgcagataagacgaatacgttagcaagcagtaaatatgttaatgcc
gatagcactaaacaaaatgcttacacaactaaagttaccaatgctgaacatattattagc
ggtacgccaacggttgttacgacaccttcagaagtaacagctgcagctaatcaagtaaac
agcgcgaaacaagaattaaatggtgacgaaagattacgtgaagcaaaacaaaacgccaat
actgctattgatgcattaacacaattaaatacacctcaaaaagctaaattaaaagaacaa
gtgggacaagccaatagattagaagacgtacaaactgttcaaacaaatggacaagcattg
aacaatgcaatgaaaggcttaagagatagtattgctaacgaaacaacagtcaaaacaagt
caaaactatacagacgcaagtccgaataaccaatcaacatataatagcgctgtgtcaaat
gcgaaaggtatcattaatcaaactaacaatccgactatggatactagtgcgattacccaa
gctacaacacaagtgaataatgctaaaaatggtttaaacggtgctgaaaacttaagaaat
gcacaaaacactgctaagcaaaacttaaatacattatcacacttaacaaataaccaaaaa
tctgccatctcatcacaaattgatcgtgcaggtcatgtgagtgaggtaactgctactaaa
aatgcagcaactgagttgaatacgcaaatgggtaacttggaacaagctatccatgatcaa
aacacagttaaacaaagtgttaaatttactgatgcagataaagctaaacgtgatgcgtat
acaaatgcggtaagcagagctgaagcaattctgaataaaacgcaaggtgcaaatacgtct
aaacaagatgttgaagcggctattcaaaatgtttcaagtgctaaaaatgcattgaatggt
gatcaaaacgttacaaatgcgaagaatgcagctaaaaatgcattaaataacttaacgtca
attaataatgcacaaaaacgtgacttaacaactaaaattgatcaagcaacaactgtagct
ggtgttgaagctgtatctaatacgagtacacaattgaatacagcgatggctaacttgcaa
aatggtattaatgataaaacaaatacactagcaagtgaaaactatcatgatgctgattca
gataagaaaactgcttatactcaagccgttacgaacgcagaaaatattttaaataaaaat
agtggatcaaatttagacaaaactgccgttgaaaacgcgttgtcacaagttgctaatgcg
aaaggtgccctaaatggtaaccataatttagagcaagctaaatcaaatgcaaacactact
ataaacggacttcaacatttaacaactgctcaaaaagataaattgaaacaacaagtgcaa
caagcacaaaatgttgcaggtgtagatactgttaaatcaagtgccaacacattaaatggt
gctatgggtacgttaagaaatagcatacaagataacacagctacgaaaaatggccaaaac
tatcttgatgctacagaacgtaacaaaacaaactataacaatgctgttgatagtgctaat
ggtgtcattaatgcaacaagcaatccaaatatggatgctaatgcaattaaccaaatcgct
acacaagtgacatcaacgaaaaatgcattagatggtacacataatttaacgcaagcgaaa
caaacagcaacaaatgccatcgatggtgctactaacttaaataaagcgcaaaaagatgcg
ttaaaagcacaagttacaagtgcgcaacgtgttgcaaatgtaacaagtatccaacaaact
gcaaatgaacttaatacagctatgggtcaattacaacatggtattgatgatgaaaatgca
acaaaacaaactcaaaaatatcgtgacgctgaacaaagtaagaaaactgcttatgatcaa
gctgtagctgctgcgaaagcaattttaaataaacaaacaggttcaaattcagataaagca
gcagttgaccgtgcattacaacaagtaacaagtacgaaagatgcattgaatggtgatgca
aaactggcagaagcgaaagcggcagctaaacaaaacttaggcactttaaaccatattacg
aatgcacaacgtactgacttagaaggccaaaacaatcaagcgacgactgttgatggcgtt
aatactgtaaaaacaaatgccaatacattagacggcgcaatgaatagcttacaaggttca
atcaatgataaagatgcgacattaagaaatcaaaattatcttgatgcggatgaatcaaaa
cgaaatgcatatacgcaagctgtcacagcggctgaaggcattttaaataaacaaactggt
ggtaacacatctaaagcagacgttgataatgcattaaatgcagttacaagagcgaaagcg
gctttaaatggtgctgacaacttaagaaatgcgaaaacttcagcaacaaatacgattgat
ggtttacctaacttaacacaattacaaaaagacaacttgaagcatcaagttgaacaagcg
caaaatgtagcaggtgtaaatggtgttaaagataaaggtaatacgttaaatactgccatg
ggtgcattacgtacaagtatccaaaatgataatacgacgaaaacaagtcaaaattatctt
gatgcatctgacagcaacaaaaataattacaatactgctgtaaataatgcaaatggtgtt
attaatgcaacgaacaatccaaatatggatgctaatgcgattaatggcatggcaaatcaa
gtcaatacaacaaaagcagcgttaaatggtgcacaaaacttagctcaagctaaaacaaat
gcgacgaacacaattaacaacgcacatgacttaaaccaaaaacaaaaagatgcattaaaa
acacaagttaacaatgcacaacgtgtatctgatgcaaataacgttcaacacactgcaact
gaattgaacagtgcgatgacagcacttaaagcagctattgctgataaagaaagaacaaaa
gcaagcggtaattatgtcaatgctgatcaagaaaaacgtcaagcgtatgattcaaaagtg
actaacgctgaaaatatcattagtggtacaccgaatgcgacattaacagtcaatgacgta
aatagtgcggcatcacaagtcaatgcggctaaaacagcattaaatggtgataacaactta
cgtgtagcgaaagagcatgccaacaatacaattgacggcttagcacaattgaataatgca
caaaaagcaaaattaaaagaacaagttcaaagtgcaactacattagatggtgttcaaact
gttaaaaatagttctcaaacgttgaatacagcgatgaaaggcttaagagatagtattgcg
aatgaagcaacaattaaagcaggtcaaaactacactgacgcaagtccaaataatcgtaac
gagtacgacagtgcagttactgcagcaaaagcaatcattaatcaaacatcgaacccaacg
atggaaccaaatactattacgcaagtaacatcacaagtgacaactaaagaacaggcatta
aatggtgcgcgaaacttagctcaagctaagacaactgcgaaaaacaacttgaataactta
acatcaattaacaatgcacaaaaagatgcgttaacgcgtagcattgatggtgcaacaaca
gtagctggtgtaaatcaagaaactgcaaaagcaacagaattaaataacgcaatgcatagt
ttacaaaatggtatcaatgatgagacacaaacaaaacaaactcagaaatacctagatgca
gagccaagtaagaaatcagcttatgatcaagcagtaaatgcagcgaaagcaattttaaca
aaagctagtggtcaaaatgtagacaaagcagcagttgaacaagcattgcaaaatgtgaac
agtacgaagacggcgttgaacggtgatgcgaaattaaatgaagctaaagcagctgcgaaa
caaacgttaggtacattaacacacattaataatgcacaacgtacagcgttagacaatgaa
attacacaagcaacaaatgttgaaggtgttaatacagttaaagccaaagcgcaacaatta
gatggtgctatgggtcaattagaaacatcaattcgtgataaagacacgacgttacaaagt
caaaattatcaagatgctgatgatgctaaacgaactgcttattctcaagcagtaaatgca
gcagcaactattttaaataaaacagctggcggtaatacacctaaagcagatgttgaaaga
gcaatgcaagctgttacacaagcaaatactgcattaaacggtattcaaaacttagatcgt
gcgaaacaggctgctaacacagcgattacaaatgcttcggacttaaatacaaaacaaaaa
gaagcattaaaagcacaagtaacaagtgcaggacgtgtatctgcagcaaatggtgttgaa
catactgcgactgaattaaatactgcgatgacagctttaaagcgtgccattgctgataaa
gctgagacaaaagctagtggtaactatgtcaatgctgatgcgaataaacgtcaagcatat
gatgaaaaagttacagctgccgaaaatatcgttagtggtacaccaacaccaacgttaaca
ccagcagatgttacaaatgcagcaacgcaagtaacgaatgctaagacgcagttaaacggt
aatcataatttagaagtagcgaaacaaaatgctaacactgcaattgatggtttaacttct
ttaaatggtccgcaaaaagcaaaacttaaagaacaagtgggtcaagcgacgacgttgcca
aatgttcaaactgttcgtgataatgcacaaacattaaacactgcaatgaaaggtctacga
gatagcattgcgaatgaagcaacgattaaagcaggtcaaaactacacagatgcaagtcaa
aacaaacaaactgactacaacagtgcagtcactgcagcaaaagcaatcattggtcaaaca
actagtccatcaatgaatgcgcaagaaattaatcaagcgaaagaccaagtgacagctaaa
caacaagcgttaaacggtcaagaaaacttaagaactgcgcaaacaaatgcgaagcaacat
ttgaacggcttaagtgacttaactgacgctcaaaaagatgcagtgaaacgtcaaatcgaa
ggtgcaacgcatgttaatgaagtaacacaagcacaaaataatgcggatgcattaaataca
gctatgacgaacttgaaaaatggtattcaagatcagaatacgattaagcaaggtgttaac
ttcactgatgccgacgaagcgaaacgtaatgcatatacaaatgcagtgacgcaagctgaa
caaattttaaataaagcacaaggtccaaatacttcaaaagacggtgtcgaaactgcgtta
gaaaatgtacaacgtgctaaaaacgaattgaacggtaatcaaaatgttgcgaacgctaag
acaactgcgaaaaatgcattgaataacctaacatcaattaataatgcacaaaaagaagca
ttgaaatcacaaattgaaggtgcgacaacagttgcaggtgtaaatcaagtgtctacaacg
gcatctgaattaaatacagcaatgagcaacttacaaaatggtattaatgatgaagcagct
acaaaagcagctcagaaatatactgatgcagatagagaaaaacaaactgcatacaatgac
gctgtaacagcagctaaaacgttattagataaaacagctggttcaaatgacaataaagca
gctgttgaacaagcattacaacgtgtgaatactgctaaaacagcattaaatggtgacgag
cgattaaatgaagcgaagaacacagctaaacaacaagtagcgacaatgtcacacttaact
gatgctcaaaaagcaaacttaacatcgcaaatcgaaagtggtacgactgttgcaggtgtt
caaggtattcaagctaatgccggtactttagatcaagcaatgaatcaattaagacaaagt
attgcttctaaagatgcgactaaatcaagcgaagattatcaagacgcgaatgcagattta
caaaatgcatacaatgatgcggtaactaatgctgaaggtattattagtgcaacgaataac
cctgaaatgaatcctgatacaattaaccaaaaagcgagccaagtgaacagtgcgaagtct
gcattgaacggtgatgaaaaattagcagcagcaaaacaaactgcgaaatcagatatcggt
cgtttgacagacttgaacaatgcacaacgaactgcggcaaatgctgaagtggatcaagca
ccaaatcttgcagctgtcacagcggctaaaaataaagcaacatcgttaaatacagcgatg
ggtaatttgaaacatgcacttgctgaaaaggataatacgaaacgtagtgtcaattacaca
gatgcggatcaaccaaaacaacaagcgtatgatactgcggttacacaagcagaagcaatt
actaatgctaatggcagcaacgcgaatgaaacacaagttcaagcagcactaaaccaattg
aatcaagctaaaaatgacttgaatggtgataataaagttgctcaagcaaaagagtcagcg
aaacgtgcattagcttcatatagtaacttgaataatgcgcaatcaactgcagcaactagt
caaattgacaatgcaacgacagtagcaggcgtaactgctgcacaaaatactgctaatgaa
ttaaatacagcaatgggtcaacttcaaaatggtataaatgaccaaaacactgttaaacaa
caagtgaactttacagatgctgaccaaggtaagaaagatgcttacacaaatgctgttacg
aatgctcaaggtattttagataaagcacacggtcaaaatatgacgaaagcacaagttgaa
gctgcattaaatcaagtaacgactgctaagaatgctttaaacggtgacgcaaatgtaaga
caagcaaaatcagatgcgaaagcaaacttaggtacattaacacacttaaataatgcacaa
aaacaagatttaacatcacaaatcgaaggcgcaacaacagtcaacggtgtaaatggtgtt
aaaacgaaagcacaagacttagatggtgcaatgcaacgattacaatcagctatagcaaat
aaagatcaaactaaagcgagcgaaaattacatcgacgcagatccaactaagaaaacagca
tttgataatgctatcacacaagctgaatcttacttaaataaagatcacggtgcgaataaa
gataagcaagctgttgaacaagcaattcaaagtgtaacgtctactgaaaatgctttgaac
ggtgacgcgaacttacaacgcgctaaaactgaagctatacaagctatcgataacttgaca
catttgaatacaccacaaaaaacagcattaaaacaacaagtgaacgctgcgcaacgtgta
tcaggtgtaactgatctgaaaaatagtgctacatcacttaataatgcgatggatcaatta
aaacaagcaattgctgatcatgacacaattgtagctagtggtaattacactaacgcgagt
cctgataagcaaggtgcttatactgatgcatataatgctgcgaaaaacattgtaaatggt
tcgcctaatgtgattacaaatgcagcagatgttacagcagcaacacaacgtgttaataat
gctgaaacaggtttaaacggtgatacaaacttagcaactgcgaagcaacaagctaaagat
gcattacgtcaaatgacacatttatctgatgcacaaaaacaaagtattactggtcaaatt
gatagcgcgacacaagtaactggcgttcaaagtgtgaaagacaacgcgacaaatcttgat
aatgcaatgaatcaacttcgaaatagtattgcgaataaagatgatgtaaaagcgagtcaa
ccatatgttgatgcagatagagataaacaaaatgcatacaatacagcagttacaaatgct
gaaaatatcattaatgcaacgagtcagccgacacttgatccatctgcagtaacacaagca
gctaatcaagtgagcactaacaaaactgcgcttaatggtgcacaaaacttagcgaataaa
aagcaagaaacgactgctaacatcaaccaattaagtcatttaaataatgctcaaaagcaa
gatttaaatacgcaagtgacaaatgcaccaaatattagcacagtaaatcaagtgaaaact
aaagctgaacaattagatcaagcaatggaacgtttaatcaacggaatccaagacaaagat
caagtgaaacaaagtgttaactttacagatgcagatccagaaaaacaaacagcatacaac
aatgcggtaactgctgctgaaaatattattaatcaagcaaatggtacaaatgcgaaccaa
tcacaagttgaagcagcactttcaactgtaacaactacgaaacaagcgttgaatggtgat
agaaaagtaacagatgctaaaaacaatgcaaaccaaacattatctacgttagataactta
aacaatgcacaaaaaggtgctgttactggaaacatcaatcaagcgcacactgtagctgaa
gtaacgcaagccattcaaaccgctcaggaactgaatacagcgatgggtaacttgaaaaat
agcttgaatgataaagacactacacttggcagtcaaaactttgcagatgcagatccagag
aagaaaaatgcatacaatgaagcggttcataatgctgaaaatattttaaataaatctaca
ggtacgaacgtgcctaaagatcaagttgaagcagctatgaatcaagtgaatgctacaaaa
gcagcgcttaatggtactcaaaaccttgaaaaagctaaacaacacgcaaatacagcaatt
gacggtttaagccatttaacaaatgcacaaaaagaggcattaaaacaattggtacaacaa
tcgactactgttgcagaagcacaaggtaatgagcaaaaagcaaacaatgttgatgcagca
atggacaaattacgtcaaagtattgcagataatgcgacaacaaaacaaaaccaaaattat
actgatgcaagtcagaataaaaaggatgcgtacaataatgctgtcacaactgcacaaggt
attattgatcaaactacaagtccaactttagatccgactgttatcaatcaagctgctgga
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caaaacttaaatacagcgatgggtaacttgaaacaagcgatagctgacaaagatgctacg
aaagcgacagttaacttcactgatgcagatcaagcaaaacaacaagcatataacactgct
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ttaaatggtaatacaaacttagcaacggcgaaacaaaatgttcaacatgctattgatcaa
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aaacaaacaacaaatccaacaatggatccaaatacaattcaacaagcattaactaaagtg
aatgacacaaatcaagcacttaacggtaatcaaaaattagctgatgccaaacaagatgct
aagacaacacttggtacactagatcatttaaatgatgctcaaaaacaagcgctaacaact
caagttgaacaagcaccagatattgcaacagttaataatgttaagcaaaatgctcaaaat
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catgcagaaggtattttatctaaagcaaatggcagcaatgcaagtcaaactgaagtggaa
caagcgatgcaacgtgtgaacgaagcgaaacaagcattgaatggtaatgacaatgtacaa
cgtgcaaaagatgcagcgaaacaagtgattacaaatgcaaatgatttaaatcaagcgcaa
aaagatgcattaaaacaacaagtcgatgctgcgcaaactgttgcaaatgtaaacacgatt
aagcaaacagcacaagatttaaatcaagcaatgacacaattgaaacaaggtattgcagat
aaagaccaaactaaagcaaatggtaactttgtcaatgctgatactgataagcaaaatgct
tacaacaatgcggtagcacatgctgaacaaataattagtggtacaccaaatgcaaacgtg
gatccacaacaagtggctcaagcgttacaacaagtgaatcaagctaagggtgatttaaac
ggtaaccataacttacaagttgctaaagacaatgcaaatacagccattgatcagttacca
aacttaaatcaaccacaaaaaacagcattaaaagaccaagtgtcgcatgcagaacttgtt
acaggtgttaatgctattaagcaaaatgctgatgcgttaaataatgcaatgggtacattg
aaacaacaaattcaagcgaacagtcaagtaccacagtcagttgactttacacaagcggat
caagacaaacaacaagcatataacaatgcggctaaccaagcgcaacaaatcgcaaatggc
ataccaacacctgtattgacgcctgatacagtaacacaagcagtgacaactatgaatcaa
gcgaaagatgcattaaacggtgatgaaaaattagcacaagcgaaacaagaagctttagca
aatcttgatacgttacgcgatttaaatcaaccacaacgtgatgcattacgtaaccaaatc
aatcaagcacaagcgttagctacagttgaacaaactaaacaaaatgcacaaaatgtgaat
acagcaatgagtaacttgaaacaaggtattgcaaacaaagatactgtcaaagcaagtgag
aactatcatgatgctgatgccgataagcaaacagcatatacaaatgcagtgtctcaagcg
gaaggtattatcaatcaaacgacaaatccaacgcttaacccagatgaaataacacgtgca
ttaactcaagtgactgatgctaaaaatggcttaaacggtgaagctaaattggcaactgaa
aagcaaaatgctaaagatgccgtaagtgggatgacgcatttaaacgatgctcaaaaacaa
gcattaaaaggtcaaatcgatcaatcgcctgaaattgctacagtgaaccaagttaaacaa
acagcaacgagcctagatcaagcaatggatcaattatcacaagctattaatgataaagct
caaacattagcggacggtaattacttaaatgcagatcctgacaaacaaaatgcgtataaa
caggcagtagcaaaagctgaagcattattgaataaacaaagtggtactaatgaagtacaa
gcacaagttgaaagcatcactaatgaagtgaacgcagcgaaacaagcattaaatggtaat
gacaatttggcaaatgcaaaacaacaagcaaaacaacaattggcgaacttaacacactta
aatgatgcacaaaaacaatcatttgaaagtcaaattacacaagcgccacttgttacagat
gtcactacgattaatcaaaaagcacaaacgttagatcatgcgatggaattattaagaaat
agtgttgcggataatcaaacgacattagcgtctgaagattatcatgatgcaactgcgcaa
agacaaaatgactataaccaagctgtaacagctgctaataatatcattaatcaaactaca
tcgcctacgatgaatccagatgatgttaatggtgcaacgacacaagtgaataatacgaaa
gttgcattagatggtgatgaaaaccttgcagcagctaaacaacaagcaaacaacagactt
gatcaattagatcatttgaataatgcgcaaaagcaacagttacaatcacaaattacgcaa
tcatctgatattgctgcagttaatggtcacaaacaaacagcagaatctttaaatactgcg
atgggtaacttaattaatgcgattgcagatcatcaagccgttgaacaacgtggtaacttc
atcaatgctgatactgataaacaaactgcttataatacagcggtaaatgaagcagcagca
atgattaacaaacaaactggtcaaaatgcgaaccaaacagaagtagaacaagctattact
aaagttcaaacaacacttcaagcgttaaatggagaccataatttacaagttgctaaaaca
aatgcgacgcaagcaattgatgctttaacaagcttaaatgatcctcaaaaaacagcatta
aaagaccaagttacagctgcaactttagtaactgcagttcatcaaattgaacaaaatgcg
aatacgcttaaccaagcaatgcatggtttaagacagagcattcaagataacgcagcaact
aaagcaaatagcaaatatatcaacgaagatcaaccagagcaacaaaactatgatcaagct
gttcaagccgcaaataatattatcaatgaacaaactgcaacattagataataatgcgatt
aatcaagcagcgacaactgtgaatacaacgaaagcagcattacatggtgatgtgaagtta
caaaatgataaagatcatgctaagcaaacggttagtcaattagcacatctaaacaatgca
caaaaacatatggaagatacgttaattgatagtgaaacaactagaacagcagttaagcaa
gatttgactgaagcacaagcattagatcaacttatggatgcattacaacaaagtattgct
gacaaagatgcaacacgtgcgagcagtgcatatgtcaatgcagaaccgaataaaaaacaa
tcctatgatgaagcagttcaaaatgctgagtctatcattgcaggattaaataatccaact
atcaataaaggtaatgtatcaagtgcgactcaagcagtaatatcatctaaaaatgcatta
gatggtgttgaacgattagctcaagataagcaaactgctggaaattctctaaatcattta
gatcaattaacaccagctcaacaacaagcgctagaaaatcaaattaataatgcaacaact
cgtggcgaagtagcacaaaaattaactgaagcacaagcacttaaccaagcaatggaagct
ttacgtaatagcattcaagatcaacagcaaacggaagcgggtagcaagtttatcaatgaa
gataaaccacaaaaagatgcttaccaagcagcagttcaaaatgcaaaagatttaattaat
caaactaacaatccaacgcttgataaagcacaagttgaacaattgacacaagctgttaac
caagctaaagataacctacacggtgatcaaaaacttgcagacgataaacaacatgcggtt
actgatttaaatcaattaaatggtttgaataatccgcaacgtcaagcacttgaaagccaa
ataaacaacgcagcaactcgtggcgaagtagcacaaaaattagctgaagcaaaagcgctt
gatcaagcaatgcaagcattacgtaatagtattcaagatcaacaacaaacagaatctggt
agcaagtttatcaatgaagataaaccgcaaaaagatgcttaccaagcagcagttcaaaat
gcaaaagatttaattaaccaaacaggtaatccaacactcgacaaatcacaagtagaacaa
ttgacacaagcagtaacaactgcaaaagataatctacatggtgatcaaaaacttgctcgt
gatcaacaacaagcagtaacaactgtaaatgcattgccaaacttaaatcatgcacaacaa
caagcattaactgatgctataaatgcagcgcctacaagaacagaggttgcacaacatgtt
caaactgctactgaacttgatcacgcgatggaaacattgaaaaataaagttgatcaagtg
aatacagataaggctcaaccaaattacactgaagcgtcaactgataaaaaagaagcagta
gatcaagcgttacaagctgcagaaagcattacagatccaactaatggttcaaatgcgaat
aaagacgctgtagaccaagtattaactaagcttcaagaaaaagaaaatgagttaaatggt
aatgagagagtcgctgaagctaaaacacaagcgaaacaaactattgaccaattaacacat
ttaaatgctgatcaaattgcaactgctaaacaaaacattgatcaagcgacgaaacttcaa
ccaattgctgaattagtagatcaagcaacgcaattgaatcaatctatggatcaattacaa
caagcagttaatgaacatgctaacgttgagcaaactgtagattacacacaagcagattca
gataaacaaaatgcttataaacaagctattgctgatgctgaaaatgtattgaaacaaaat
gcgaataagcaacaagtggatcaagcacttcaaaatattttaaatgcaaaacaagcatta
aatggtgatgaacgtgtagcacttgctaaaacaaatggtaaacatgacatcgaccaattg
aatgcattaaacaatgctcaacaagatggatttaaaggtcgcatcgatcaatcaaacgat
ttaaatcaaatccaacaaattgtagatgaggctaaggcacttaatcgtgcaatggatcaa
ttgtcacaagaaatcactgacaatgaaggacgcacgaaaggtagcacgaactatgtcaat
gcagatacacaagtcaaacaagtatatgatgaaacggttgataaagcgaaacaagcactt
gataaatcgactggtcaaaacttaactgcaaaacaagttatcaaattaaatgatgcagtc
actgcagctaagaaagcattaaatggtgaagaaagacttaataatcgtaaagctgaagca
ttacaaagattggatcaattaacacatctaaacaatgctcaaagacaattagcaatccaa
caaattaataatgctgaaacgctaaataaagcatctcgagcaattaatagagcaactaaa
ttagataatgcaatgggtgcagtacaacaatatattgacgaacagcaccttggtgttatc
agcagcacaaattacatcaatgcagatgacaatttgaaagcaaattatgataatgcaatt
gcgaatgcagcacatgagttagataaagtgcaaggtaatgcaattgcaaaagctgaagca
gagcaattgaaacaaaatattatcgatgctcaaaatgcattaaatggagaccaaaacctt
gcaaatgccaaagataaagcaaatgcgtttgttaattcgttaaatggattaaatcaacag
caacaagatcttgcacataaagcaattaacaatgccgatactgtatcagatgtaacagat
attgttaataatcaaattgacttaaatgatgcaatggaaacattgaaacatttagttgac
aatgaaattccaaatgcagagcaaactgtcaattaccaaaacgctgacgataatgctaaa
acaaacttcgatgatgccaaacgtctagcaaatacattgctaaatagtgataacacaaat
gtgaatgatatcaatggcgcaatccaagcagtcaatgatgcaatccataatcttaatggt
gatcaacgactacaagatgctaaagacaaggcaattcaatctattaatcaagctttagct
aataagctaaaagaaatcgaagcttcaaatgcgacggatcaagacaagcttattgcgaaa
aataaagcagaagaattggcaaacagcatcatcaacaacattaataaagcaacaagtaat
caggctgtatctcaagttcaaacagcaggcaaccacgcgattgaacaagtgcatgccaat
gaaataccaaaagcaaaaattgatgccaataaagacgttgataagcaagttcaagcatta
attgacgaaattgatcgaaatccaaatctaacagataaggaaaaacaagcacttaaagat
cgtattaatcaaatacttcaacaaggtcataacggcattaacaatgcgatgactaaagaa
gaaattgaacaagccaaagcacaacttgcgcaagcattacaagacatcaaagatttagtg
aaagctaaagaagatgcgaaacaagatgttgataaacaagttcaagctttaattgacgaa
atcgatcaaaatccaaatctaacagataaggaaaaacaagcacttaaagatcgtattaat
caaatacttcaacaaggtcatarcgacattamcaatgcgatgacaaaagaagcaattgaa
caagcaaaagaacgtttagcgcaagcattgcaagacatcaaagatttagtgaaagctaaa
gaagatgcgaaaaatgatattgataaacgtgtacaagctttaattgacgaaatcgatcaa
aatccaaatctaacagataaggaaaaacaagcacttaaagatcgaattaatcaaatactt
caacaaggtcataacgacattaacaatgcgctgactaaagaagaaattgagcaggcaaaa
gcacaacttgcacaagcattgcaagacatcaaagatttagtgaaagctaaagaagatgcg
aaaaatgcaataaaagccttagctaatgcgaagcgtgatcaaatcaattcaaatccagat
ttaacacctgagcaaaaagcaaaagcgctcaaagaaattgacgaagctgaaaaacgagca
ctacaaaacgttgagaatgctcaaactatagatcaattaaatcgaggattaaacttaggt
ttagatgacattagaaatacacatgtatgggaggttgatgaacaacctgctgtaaatgaa
atttttgaagcaacacctgagcaaatcctagttaatggtgaactcattgtacatcgtgat
gacatcattacagaacaagatattcttgcacacataaacttaattgatcagctttcagca
gaagtcatcgatacaccatcaactgcaacgatttctgatagcttaacagcaaaagttgaa
gttacattgcttgatggatcaaaagtgattgttaatgttcctgtaaaagttgtagaaaaa
gaattgtcagtagtcaaacaacaggcaattgaatcaatcgaaaatgcggcacaacaaaag
attaatgaaatcaataatagtgtgacattaacactggaacaaaaagaagctgcaattgca
gaagttaataagcttaaacaacaagcaattgatcatgttaacaatgcacctgatgttcat
tcagttgaagaaattcaacaacaagaacaagcgcatattgaacaatttaatccagaacaa
tttacgattgaacaagcaaaatcaaatgcaattaaatcgattgaagatgcaattcaacat
atgattgatgaaatcaaagctcgtactgatctaacagataaagagaagcaagaagctatt
gctaagttaaatcaattaaaagaacaagcaattcaagcgattcaacgtgcgcaaagcatc
gatgaaataagtgagcaattggaacaatttaaagctcaaatgaaagcagctaatccaaca
gcaaaagaactagctaaacgcaagcaagaagctattagtagaattaaagacttttcaaat
gaaaaaataaatagtattcgaaatagtgaaattggcacagctgatgaaaaacaagcagca
atgaatcaaattaacgaaattgtgcttgaaacaattagagatattaataatgcgcataca
ttacagcaagttgaggctgcattgaacaatggtattgctcgaatttcagcagtacaaatt
gtaacatctgatcgtgctaaacaatcgtcaagtactggaaatgaatctaatagccattta
acaattggttatggaactgcaaatcatccatttaacagttcgactattggacataaaaag
aaacttgatgaagatgatgacattgatccacttcatatgcgtcactttagtaataatttc
ggtaatgttattaaaaacgctattggtgtggtgggtatctctggtttactagctagtttc
tggttcttcattgccaaacgtcgtcgtaaagaagatgaagaggaagaattagaaataaga
gataataataaagattcaataaaagagactttagacgatacaaaacatttaccactttta
tttgcgaaacgtcgcagaaaagaagatgaagaagatgttactgttgaagaaaaagattcg
ctaaataatggcgagtcactcgataaagttaaacatacgccgttcttcttaccaaaacgt
cgtcgtaaagaagatgaagaagatgtggaagttacaaatgaaaacacagatgaaaaagtg
ttgaaagataacgaacattcaccactcttattcgcaaaacgacgcaaagataaagaggaa
gatgttgaaacaacaactagtattgaatctaaagatgaggacgttcctttattattggct
aaaaagaaaaatcaaaaagataaccaatccaaagacaaaaagtcagcatcaaaaaatact
tctaaaaaggtagcagctaaaaagaagaaaaagaaagctaagaaaaataaaaaataa
440.
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enresqvqnsqnsqngqslsatheneqpnisqanlvdqkvaqssttndeqpasqnvntkk
dsataattqpdkeqskhkqnesqsankngndnraahvenheanvvtasdssdngnvqhdr
nelqaffdanyhdyrfidrenadsgtfnyvkgifdkintllgsndpinnkdlqlaykele
qavalirtmpqrqqtsrrsnriqtrsvesraaeprsvsdyqnanssyyvenandgsgypv
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fwfalpadqvpvgrtdfvtvnsdgtnvqwshgagagankplqqmweygvndphrshdfki
rnrsgqviydwptvhiysledlsrasdyfseagatpatkafgrqnfeyingqkpaespgv
pkvytfigqgdasytisfktqgptvnklyyaaggraleynqlfmysqlyvestqdhqqrl
nglrqvvnrtyrigttkrvevsqgnvqtkkvlestnlniddfvddplsyvktpsnkvlgf
ysnnantnafrpggaqqlneyqlsqlftdqklqeaartrnpirlmigfdypdaygnsetl
vpvnltvlpeiqhnikffknddtqniaekpfskqaghpvfyvyagnqgnasvnlggsvts
iqplrinltsnenftdkdwqitgiprtlhienstnrpnnarernielvgnllpgdyfgti
rfgrkeqlfeirvkphtptitttaeqlrgtalqkvpvnisgipldpsalvylvaptnqtt
nggseadqipsgytilatgtpdgvhntitirpqdyvvfippvgkqiravvyynkvvasnm
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tkadknngslsitgrvsmnqafnsditfkvsatdnvnnttndsqskhvsihvgkisedah
pivlgntekvvvvnptavsndekqsiitafmnknqnirgylastdpvtvdnngnvtlhyr
dgssttldatnvmtyepvvkpeyqtvnaaktatvtiakgqsfsigdikqyftlsngqpip
sgtftnitsdrtiptaqevsqmnagtqlyhitatnayhkdsedfyislkiidvkqpegdq
rvyrtstydlttdeiskvkqafinanrdvitlaegdisvtntpnganvstitvninkgrl
tksfasnlanmnflrwvnfpqdytvtwtnakianrptdgglswsddhksliyrydatlgt
qittndiltmlkatttvpglrnnitgneksqaeaggrpnfrttgysqsnattdgqrqftl
ngqviqvldiinpsngyggqpvtnsntranhsnstvvnvnepaangagaftidhvvksns
thnasdavykaqlyltpygpkqyvehlnqntgnttdainiyfvpsdlvnptisvgnytnh
qvfsgetftntitandnfgvqsvtvpntsqitgtvdnnhqhvsatapnvtsatnktinll
atdtsgntattsfnvtvkplrdkyrvgtsstaanpvrianisnnatvsqadqttiinslt
ftetvpnrsyarasaneitsktvsnvsrtgnnanvtvtvtyqdgttstvtvpvkhvipei
vahshytvqgqdfpagngssasdyfklsngsdiadatitwvsgqapnkdntrigeditvt
ahilidgettpitktatykvvrtvpkhvfetargvlypgvsdmydakqyvkpvnnswstn
aqhmnfqfvgtygpnkdvvgistrlirvtydnrqtedltilskvkpdppridansvtyka
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smnnvtyttqdehgqvvtvtrnesvdsndsatvtvtpqlqattegavfikggdgfdfghv
erfiqnpphgatvawhdspdtwkntvgnthktavvtlpngqgtrnvevpvkvypvanaka
psrdvkgqnltngtdamnyitfdpntntngitaawanrqqpnnqqagvqhlnvdvtypgi
saakrvpvtvnvyqfefpqttytttvggtlasgtqasgyahmqnatglptdgftykwnrd
ttgtndanwsamnkpnvakvvnakydviynghtfatslpakfvvkdvqpakptvtetaag
aitiapganqtvnthagnvttyadklvikrngnvvttftrrnntspwvkeasaatvagia
gtnngitvaagtfnpadtiqvvatqgsgetvsdeqrsddftvvapqpnqattkiwqnghi
ditpnnpsghlinptqamdiaytekvgngaehsktinvvrgqnnqwtiankpdyvtldaq
tgkvtfnantikpnssititpkagtghsvssnpstltapaahtvntteivkdygsnvtaa
einnavqvankrtatikngtamptnlaggstttipvtvtyndgsteevqesiftkadkre
litaknhlddpvstegkkpgtitqynnamhnaqqqintakteaqqvinneratpqqvsda
ltkvraaqtkidqakallqnkednsqlvtsknnlqssvnqvpstagmtqqsidnynakkr
eaeteitaaqrvidngdataqqisdekhrvdnaltalnqakhdltadthaleqavqqlnr
tgtttgkkpasitaynnsiralqsdltsaknsanaiiqkpirtvqevqsaltnvnrvner
ltqainqlvpladnsalktaktkldeeinksvttdgmtqssiqayenakragqtestnaq
nvinngdatdqqiaaektkveekynslkqaiagltpdlaplqtaktqlqndidqptsttg
mtsasiaafneklsaartkiqeidrvlashpdvatirqnvtaanaaksaldqarngltvd
kaplenaknqlqysidtqtsttgmtqdsinaynakltaarnkiqqinqvlagsptveqin
tntstanqaksdldharqaltpdkaplqtaktqleqsinqptdttgmttaslnaynqklq
aarqklteinqvlngnptvqnindkvteanqakdqlntarqgltldrqpalttlhgasnl
nqaqqnnftqqinaaqnhaaletiksnitalntamtklkdsvadnntiksdqnytdatpa
nkqaydnavnaakgvigettnptmdvntvnqkaasvkstkdaldgqqnlqrakteatnai
thasdlnqaqknaltqqvnsaqnvqavndikqttqslntamtglkrgvanhnqvvqsdny
vnadtnkkndynnaynhandiingnaqhpvitpsdvnnalsnvtskehalngeaklnaak
qeantalghlnnlnnaqrqnlqsqingahqidavntikqnatnlnsamgnlrqavadkdq
vkrtedyadadtakqnaynsavssaetiinqttnptmsvddvnratsavtsnknalngye
klaqsktdaaraidalphlnnaqkadvkskinaasniagvntvkqqgtdlntamgnlqga
indeqttlnsqnyqdatpskktaytnavqaakdilnksngqnktkdqvteamnqvnsakn
nldgtrlldqakqtakqqlnnmthlttaqktnltnqinsgttvagvqtvqsnantldqam
ntlrqsiankdatkasedyvdanndkqtaynnavaaaetiinansnpemnpstitqkaeq
vnssktalngdenlaaakqnaktylntltsitdaqknnlisqitsatrvsgvdtvkqnaq
hldqamaslqnginnesqvkssekyrdadtnkqqeydnaitaakailnkstgpntaqnav
eaalqrvnnakdalngdakliaaqnaakqhlgtlthittaqrndltnqisqatnlagves
vkqnansldgamgnlqtaindksgtlasqnfldadeqkrnaynqavsaaetilnkqtgpn
taktaveqalnnvnnakhalngtqnlnnakqaaitaingasdlnqkqkdalkaqangaqr
vsnaqdvqhnatelntamgtlkhaiadktntlasskyvnadstkqnayttkvtnaehiis
gtptvvttpsevtaaanqvnsakqelngderlreakqnantaidaltqlntpqkaklkeq
vgqanrledvqtvqtngqalnnamkglrdsianettvktsqnytdaspnnqstynsavsn
akgiinqtnnptmdtsaitqattqvnnaknglngaenlrnaqntakqnlntlshltnnqk
saissqidraghvsevtatknaatelntqmgnleqaihdqntvkqsvkftdadkakrday
tnavsraeailnktqgantskqdveaaiqnvssaknalngdqnvtnaknaaknalnnlts
innaqkrdlttkidqattvagveavsntstqlntamanlqngindktntlasenyhdads
dkktaytqavtnaenilnknsgsnldktavenalsqvanakgalngnhnleqaksnantt
inglqhlttaqkdklkqqvqqaqnvagvdtvkssantlngamgtlrnsiqdntatkngqn
yldaternktnynnavdsangvinatsnpnmdanainqiatqvtstknaldgthnltqak
qtatnaidgatnlnkaqkdalkaqvtsaqrvanvtsiqqtanelntamgqlqhgiddena
tkqtqkyrdaeqskktaydqavaaakailnkqtgsnsdkaavdralqqvtstkdalngda
klaeakaaakqnlgtlnhitnaqrtdlegqnnqattvdgvntvktnantldgamnslqgs
indkdatlrnqnyldadeskrnaytqavtaaegilnkqtggntskadvdnalnavtraka
alngadnlrnaktsatntidglpnltqlqkdnlkhqveqaqnvagvngvkdkgntlntam
galrtsiqndnttktsqnyldasdsnknnyntavnnangvinatnnpnmdanaingmanq
vnttkaalngaqnlaqaktnatntinnahdlnqkqkdalktqvnnaqrvsdannvqhtat
elnsamtalkaaiadkertkasgnyvnadqekrqaydskvtnaeniisgtpnatltvndv
nsaasqvnaaktalngdnnlrvakehanntidglaqlnnaqkaklkeqvqsattldgvqt
vknssqtlntamkglrdsianeatikagqnytdaspnnrneydsavtaakaiinqtsnpt
mepntitqvtsqvttkeqalngarnlaqakttaknnlnnltsinnaqkdaltrsidgatt
vagvnqetakatelnnamhslqngindetqtkqtqkyldaepskksaydqavnaakailt
kasgqnvdkaaveqalqnvnstktalngdaklneakaaakqtlgtlthinnaqrtaldne
itqatnvegvntvkakaqqldgamgqletsirdkdttlqsqnyqdaddakrtaysqavna
aatilnktaggntpkadveramqavtqantalngiqnldrakqaantaitnasdlntkqk
ealkaqvtsagrvsaangvehtatelntamtalkraiadkaetkasgnyvnadankrqay
dekvtaaenivsgtptptltpadvtnaatqvtnaktqlngnhnlevakqnantaidglts
lngpqkaklkeqvgqattlpnvqtvrdnaqtlntamkglrdsianeatikagqnytdasq
nkqtdynsavtaakaiigqttspsmnaqeinqakdqvtakqqalngqenlrtaqtnakqh
lnglsdltdaqkdavkrqiegathvnevtqaqnnadalntamtnlkngiqdqntikqgvn
ftdadeakrnaytnavtqaeqilnkaqgpntskdgvetalenvqraknelngnqnvanak
ttaknalnnltsinnaqkealksqiegattvagvnqvsttaselntamsnlqngindeaa
tkaaqkytdadrekqtayndavtaaktlldktagsndnkaaveqalqrvntaktalngde
rlneakntakqqvatmshltdaqkanltsqiesgttvagvqgiqanagtldqamnqlrqs
iaskdatkssedyqdanadlqnayndavtnaegiisatnnpemnpdtinqkasqvnsaks
alngdeklaaakqtaksdigrltdlnnaqrtaanaevdqapnlaavtaaknkatslntam
gnlkhalaekdntkrsvnytdadqpkqqaydtavtqaeaitnangsnanetqvqaalnql
nqakndlngdnkvaqakesakralasysnlnnaqstaatsqidnattvagvtaaqntane
lntamgqlqngindqntvkqqvnftdadqgkkdaytnavtnaqgildkahgqnmtkaqve
aalnqvttaknalngdanvrqaksdakanlgtlthlnnaqkqdltsqiegattvngvngv
ktkaqdldgamqrlqsaiankdqtkasenyidadptkktafdnaitqaesylnkdhgank
dkqaveqaiqsvtstenalngdanlqrakteaiqaidnlthlntpqktalkqqvnaaqrv
sgvtdlknsatslnnamdqlkqaiadhdtivasgnytnaspdkqgaytdaynaaknivng
spnvitnaadvtaatqrvnnaetglngdtnlatakqqakdalrqmthlsdaqkqsitgqi
dsatqvtgvqsvkdnatnldnamnqlrnsiankddvkasqpyvdadrdkqnayntavtna
eniinatsqptldpsavtqaanqvstnktalngaqnlankkqettaninqlshlnnaqkq
dlntqvtnapnistvnqvktkaeqldqamerlingiqdkdqvkqsvnftdadpekqtayn
navtaaeniinqangtnanqsqveaalstvtttkqalngdrkvtdaknnanqtlstldnl
nnaqkgavtgninqahtvaevtqaiqtaqelntamgnlknslndkdttlgsqnfadadpe
kknayneavhnaenilnkstgtnvpkdqveaamnqvnatkaalngtqnlekakqhantai
dglshltnaqkealkqlvqqsttvaeaqgneqkannvdaamdklrqsiadnattkqnqny
tdasqnkkdaynnavttaqgiidqttsptldptvinqaagqvsttknalngnenleaakq
qasqslgsldnlnnaqkqtvtdqingahtvdeanqikqnaqnlntamgnlkqaiadkdat
katvnftdadqakqqayntavtnaeniiskanggnatqaeveqaikqvnaakqalngnan
vqhakdeatalinssndlnqaqkdalkqqvqnattvagvnnvkqtaqelnnamtqlkqgi
adkeqtkadgnfvnadpdkqnaynqavakaealisatpdvvvtpseitaalnkvtqaknd
lngntnlatakqnvqhaidqlpnlnqaqrdeyskqitqatlvpnvnaiqqaattlndamt
qlkqgiankaqikgsenyhdadtdkqtaydnavtkaeellkqttnptmdpntiqqaltkv
ndtnqalngnqkladakqdakttlgtldhlndaqkqalttqveqapdiatvnnvkqnaqn
lnnamtnlnnalqdktetlnsinftdadqakkdaytnavshaegilskangsnasqteve
qamqrvneakqalngndnvqrakdaakqvitnandlnqaqkdalkqqvdaaqtvanvnti
kqtaqdlnqamtqlkqgiadkdqtkangnfvnadtdkqnaynnavahaeqiisgtpnanv
dpqqvaqalqqvnqakgdlngnhnlqvakdnantaidqlpnlnqpqktalkdqvshaelv
tgvnaikqnadalnnamgtlkqqiqansqvpqsvdftqadqdkqqaynnaanqaqqiang
iptpvltpdtvtqavttmnqakdalngdeklaqakqealanldtlrdlnqpqrdalrnqi
nqaqalatveqtkqnaqnvntamsnlkqgiankdtvkasenyhdadadkqtaytnavsqa
egiinqttnptlnpdeitraltqvtdaknglngeaklatekqnakdavsgmthlndaqkq
alkgqidqspeiatvnqvkqtatsldqamdqlsqaindkaqtladgnylnadpdkqnayk
qavakaeallnkqsgtnevqaqvesitnevnaakqalngndnlanakqqakqqlanlthl
ndaqkqsfesqitqaplvtdvttinqkaqtldhamellrnsvadnqttlasedyhdataq
rqndynqavtaanniinqttsptmnpddvngattqvnntkvaldgdenlaaakqqannrl
dqldhlnnaqkqqlqsqitqssdiaavnghkqtaeslntamgnlinaiadhqaveqrgnf
inadtdkqtayntavneaaaminkqtgqnanqteveqaitkvqttlqalngdhnlqvakt
natqaidaltslndpqktalkdqvtaatlvtavhqieqnantlnqamhglrqsiqdnaat
kanskyinedqpeqqnydqavqaanniineqtatldnnainqaattvnttkaalhgdvkl
qndkdhakqtvsqlahlnnaqkhmedtlidsettrtavkqdlteaqaldqlmdalqqsia
dkdatrassayvnaepnkkqsydeavqnaesiiaglnnptinkgnvssatqavissknal
dgverlaqdkqtagnslnhldqltpaqqqalenqinnattrgevaqklteaqalnqamea
lrnsiqdqqqteagskfinedkpqkdayqaavqnakdlinqtnnptldkaqveqltqavn
qakdnlhgdqkladdkqhavtdlnqlnglnnpqrqalesqinnaatrgevaqklaeakal
dqamqalrnsiqdqqqtesgskfinedkpqkdayqaavqnakdlinqtgnptldksqveq
ltqavttakdnlhgdqklardqqqavttvnalpnlnhaqqqaltdainaaptrtevaqhv
qtateldhametlknkvdqvntdkaqpnyteastdkkeavdqalqaaesitdptngsnan
kdavdqvltklqekenelngnervaeaktqakqtidqlthlnadqiatakqnidqatklq
piaelvdqatqlnqsmdqlqqavnehanveqtvdytqadsdkqnaykqaiadaenvlkqn
ankqqvdqalqnilnakqalngdervalaktngkhdidqlnalnnaqqdgfkgridqsnd
lnqiqqivdeakalnramdqlsqeitdnegrtkgstnyvnadtqvkqvydetvdkakqal
dkstgqnltakqviklndavtaakkalngeerlnnrkaealqrldqlthlnnaqrqlaiq
qinnaetlnkasrainratkldnamgavqqyideqhlgvisstnyinaddnlkanydnai
anaaheldkvqgnaiakaeaeqlkqniidaqnalngdqnlanakdkanafvnslnglnqq
qqdlahkainnadtvsdvtdivnnqidlndametlkhlvdneipnaeqtvnyqnaddnak
tnfddakrlantllnsdntnvndingaiqavndaihnlngdqrlqdakdkaiqsinqala
nklkeieasnatdqdkliaknkaeelansiinninkatsnqavsqvqtagnhaieqvhan
eipkakidankdvdkqvqalideidrnpnltdkekqalkdrinqilqqghnginnamtke
eieqakaqlaqalqdikdlvkakedakqdvdkqvqalideidqnpnltdkekqalkdrin
qilqqghxdixnamtkeaieqakerlaqalqdikdlvkakedakndidkrvqalideidq
npnltdkekqalkdrinqilqqghndinnaltkeeieqakaqlaqalqdikdlvkakeda
knaikalanakrdqinsnpdltpeqkakalkeideaekralqnvenaqtidqlnrglnlg
lddirnthvwevdeqpavneifeatpeqilvngelivhrddiiteqdilahinlidqlsa
evidtpstatisdsltakvevtlldgskvivnvpvkvvekelsvvkqqaiesienaaqqk
ineinnsvtltleqkeaaiaevnklkqqaidhvnnapdvhsveeiqqqeqahieqfnpeq
ftieqaksnaiksiedaiqhmideikartdltdkekqeaiaklnqlkeqaiqaiqraqsi
deiseqleqfkaqmkaanptakelakrkqeaisrikdfsnekinsirnseigtadekqaa
mnqineivletirdinnahtlqqveaalnngiarisavqivtsdrakqssstgnesnshl
tigygtanhpfnsstighkkkldedddidplhmrhfsnnfgnviknaigvvgisgllasf
wffiakrrrkedeeeeleirdnnkdsiketlddtkhlpllfakrrrkedeedvtveekds
lnngesldkvkhtpfflpkrrrkedeedvevtnentdekvlkdnehspllfakrrkdkee
dvetttsieskdedvplllakkknqkdnqskdkksaskntskkvaakkkkkkakknkk
441.
atgttctttgatgatgctaaagaagcatcaagagtacttgaaataacattgacgaaaaga
gatgctaaaaaagaaaatcctattccgatgtgtggcgtaccatatcattctgctgataat
tacattgaaacattgattaataaggggtataaggtcgctatatgtgaacaaatggaagat
ccaaagcaaacaaaaggaatggttagaagagaagttgtaagaatcatcacaccaggaact
gttatggatcaaaatggtatggatgaaaagaaaaataattatattttaagttttatcgaa
aatgaagaatttggattatgctattgtgatgtttctacaggagaactcaaagtaactcat
ttcaaagatacagcaaccttgcttaatgagattacaacaattaatcccaatgaaatcgtc
ataaagcaagctctatctgaagaattaaaaagacaaatcaacatgataactgagacgatt
actgttcgcgaagatatatctgatgaagattatgatatgaatcagttgacacatcagtta
atgcatgacacaactcaattattgttagattacattcatcacacacaaaagcgagattta
tctcatattgaggaagtaattgaatatgctgcagttgattatatgaagatggattattat
gcgaagcgaaatttagagctgacagagagcatacgattaaaatcaaaaaaagggactttg
ttatggttaatggatgagacaaaaacaccgatgggtgctagacgtttaaagcagtggatt
gatcgtccattaattaataaacaacaaatcaacgacagattaaatattgttgaagagttt
atggaccgttttattgaaagagatacattacgtaatcatttaaatcaagtgtatgacata
gaacgactagtaggaagagtgagttatggaaacgtaaatgcaagagatttaatacaactt
aagcattctatatccgaaatacctcacattaaagcattactcaatgaattgggtgcacaa
actaccacgcaatttaaagaattagaacctttagatgacttgttacaaattttagaagaa
agtttagttgaagaaccacctatttccatcaaagatggaggattatttaaaaatggcttc
aacgcgcaacttgatgaatatttagaagcttcaaaaaatggtaaaacttggcttgcagaa
ttacaagctaaggaacgtgaacgtacaggtattaagtcattgaaaattagttttaataaa
gtgtttggttattttattgaaattacacgtgcaaacttaaataattttcaacctgaagcg
tttggctataatcgaaaacaaacattatctaatgctgaacgatttattacggatgaatta
aaagaaaaagaagatataatacttggtgctgaagataaagcagtagagttagaatatgaa
ttatttgttaaattacgagaacacattaaaacgtacactgaacgtttacaaaagcaagcg
aaaatcatttcagaacttgattgtttacaaagttttgctgaaattgctcaaaaatataat
tatgtcaaacctacatttagtgatgataaagttttacatttagaaaactcaagacatcct
gttgttgagagagtgatggattataatgattatgtacctaatgattgccatcttgatgat
gaaacgtttatttatctcattacgggacctaatatgtcaggtaagtcaacatatatgaga
caagttgctataataagtatcatggctcaaatgggagcatatgtaccatgtgattcagca
acattacctatatttgatcaaatttttactaggattggtgcagcagatgatcttgtatca
ggtaaaagtacatttatggtagaaatgttagaagctcaaaaagctttaacttatgctact
gaaaatagtttaattatctttgacgaaataggaagaggtacatccacttatgatggtctt
gcgttagcgcaagcgatgattgaatatgttgctcaaacttcccatgctaagacacttttc
tcaacacattatcatgaattgacatcacttgatcaaatgcttaagtgtttaaaaaatgta
catgttgctgcaaacgagtatcaaggtgaactgatatttttgcataaagtcaaagatggc
gctgtggatgatagctatggtattcaagtggcaaaattagcggatttacctaatgaagtc
attgatagagcgcaagttatattaaatgcatttgagcaaaaaccttcgtatcaactctct
catgagaatactgacaatcaacaaacggttccgtcgtataacgattttggtcgaacagaa
gaagagcaatcagttatagaaacacatacatcaaatcataattatgagcaagcgaccttt
gatttatttgatggttacaatcaacaaagtgaagttgaatgtcaaattcgagaattgaat
ctatccaatatgacaccattggaagccttaatcaagctgaatgaattacaaagtcaatta
aag
442.
mffddakeasrvleitltkrdakkenpipmcgvpyhsadnyietlinkgykvaiceqmed
pkqtkgmvrrevvriitpgtvmdqngmdekknnyilsfieneefglcycdvstgelkvth
fkdtatllneittinpneivikqalseelkrqinmitetitvredisdedydmnqlthql
mhdttqllldyihhtqkrdlshieevieyaavdymkmdyyakrnleltesirlkskkgtl
lwlmdetktpmgarrlkqwidrplinkqqindrlniveefmdrfierdtlrnhlnqvydi
erlvgrvsygnvnardliqlkhsiseiphikallnelgaqtttqfkeleplddllqilee
slveeppisikdgglfkngfnaqldeyleaskngktwlaelqakerertgikslkisfnk
vfgyfieitranlnnfqpeafgynrkqtlsnaerfitdelkekediilgaedkaveleye
lfvklrehiktyterlqkqakiiseldclqsfaeiaqkynyvkptfsddkvlhlensrhp
vvervmdyndyvpndchlddetfiylitgpnmsgkstymrqvaiisimaqmgayvpcdsa
tlpifdqiftrigaaddlvsgkstfmvemleaqkaltyatensliifdeigrgtstydgl
alaqamieyvaqtshaktlfsthyheltsldqmlkclknvhvaaneyqgeliflhkvkdg
avddsygiqvakladlpnevidraqvilnafeqkpsyqlshentdnqqtvpsyndfgrte
eeqsviethtsnhnyeqatfdlfdgynqqsevecqirelnlsnmtplealiklnelqsqlk
443.
atgattccaactaaacctcatgatgtgatttggacagatgcacaatggcaaagtatttat
gcgaaaggacaggacatacttgttgctgctgcagcaggttccggtaaaacagccgttcta
gttgagcgtattatacaacgtatactaagagatgatgtagatgtagatcggttactagtt
gtaacatttacgaatttaagcgcacgtgagatgaagcatcgagttgataaacgtatacaa
gaagcatcttttaaggatcctaacaatgaacatttaaagaatcagcgaatcaaaattcat
caagcacagatttctactttacacagtttctgtttgaaattgattcagcagcattatgat
gtattagatatcgatcctcattttagaacaagtagtgaagcggaaaatatattattatta
gaacaaactattgatgatgttttagaacaacactatgataaattagatcctcactttata
gaattaaccgaacaactatcatcagataggaatgatgatcaatttagaagtattattaag
cagttatattttttcagtattgctaatcctcaaccatttgaatggctcaatcaattagcg
caaccatacaaagaagaaaataaacagcaacaattaatgcagcttatcaatgatttagca
atgatttttatgaaagcaggatatgaggaattacaaaaaagttatgacttattctcaatg
atggaaagtgttgataagcagcttgaagttattgaaaccgaacgcatgtttattactaaa
gctattgaaggtaaagtattaaatacagatgttatcacgcaacatgaatttatgagtcgt
tttccggcaataaatagcaagataaaagaagcaaatgaaggcatggaagatgctttaaat
gaagcaaaacaacattatgataaatataaatctttagttatgaaagtaaagaatgattat
ttttctagaaatgcagaagatttgcaaagagatatgcaacaactcgcacctcgagtggct
tatttagctcaaatagttcaagatgtgattcaatcatttggtgttcaaaaacgaagtcgt
aatattttggatttttcagattatgaacattttgcattacgcattcttactaacgaagat
ggctcaccttcgcgtatcgctgaaacgtatcgtgaacattttaaagaaatcctagttgat
gagtatcaagatactaatagagtgcaagaaaaaatattatcttgtattaaaactggtgaa
gaacacgatggtaacttgttcatggttggggatgtgaagcagtctatttataaatttaga
caagctgatcctagtttatttattgaaaaatataatcgcttttctagtagtggaaatgaa
agtggcttgcgcattgacttatcgcaaaactttcgttcgagacaggaagtgttatctaca
accaattacttgttcaaacatatgatggatgaacaagtaggagaaatttcatatgatgat
gcagcgcaattgtattttggtgcaccatatgacgaagtttcacatcctgttcaattacga
gcacttgttgaggcaagttcagaaaatagtgacttaactggaagtgaacaagaagcgaat
tacattgttgaacaagttaaagatattattaatcatcaaaacgtatacgatatgaaaaca
ggtcaatacagaaaagcaacatataaagatatcgtaattttagagcgaagttttggtcaa
gcgcgtaatcttcaacaagcttttaaaaataatgatatcccttttcacgtaaatagtaag
gaagggtattttgagcaaactgaagtacgtcttgtgctttcatttttaagaacaatagat
aatccacttcaagacatttatttagtgggattgatgcgttctgtaatatatcaatttact
gaagaagaattagctgaaataagagttgtaagccctcatgatgattacttttatcaatct
ataaaaaattatatgattgatgaaaaagctgattctagattggttgacaagttaaatcgt
tttattcaggatatacaaaaatatcaaaattatagtcaaagtcaaccggtttaccaatta
attgataaattttataatgatcattttgtaattcagtactttagcggtcttattggaggt
aaaggtagaagagcaaatctgtatgggctatttaataaagctgttgaatttgaaaattca
agtttcagaggtttattccaatttattcgttttattgatgagcttattgatcgtaaaaaa
gattttggtgaagaaaatgtcgtaggtcctaacgataatgtggttagaatgatgacgatt
cacagtagtaaaggattagaatttccatttgtaatttactcaggattatctaaaaaattc
aacaaaggtgacctgaatgcaccagttattctaaatcaacaatatggtttaggtatggat
tattttgatgtaaataaagatatggcttttccttcacttgcctctgtggcatatagagca
ataaatgaaaaagaacttatatcagaagagatgcgtttaatctatgttgcgttgacacga
gcaaaagagcaacttattttagttggaagagtcaaagatgaaaagtcgttaattaaatat
gaacaattagctgtttcagacacacatatagcagttaatgaacgccttactgctaccaat
ccatttgttctaatttatggtgttttggctaagcatcaatcgccttcattgccaaatgat
caaagatttgaaagagatattgatcaattaaattctgaagtgaagccacgtgtatcaata
gtgattgatcattatgaggatgtttcaactgaagaagtagtcaatgataatgaaataaga
acaatcgaagaattaaaggccataaatactggtaatgaagatgtgaaaattaaaattcat
caacagctttcttatgactatccttttaaagttaacacgatgaaaccatctaaacagtcg
gtatcagagttaaaacgtcaattagaaactgaagaaagtaatacaaattatgatagagta
cgtcaatatcgtattggtgttgcatcatatgaaagacccaagtttcttacccaaacaaaa
aaaagaaaagcaaatgaaatagggactttaatgcatacagtcatgcaacacttacctttt
agagaacaacgtttaacaaaagacgaattatttcaatatatcgatcgattgattgacaaa
caacttattgatgaagatgcaaaagaggatattagaatagatgagattatgcatttcatt
gatggccctctctatatggaaatagctcaagctgacaatgtttatactgaattacctttt
gtggtaaatcaaattaaagttgatggacttacaagtgaagatgaagatgtatccattatt
caaggtatgattgatttaatatatgaaagtgacggacaattttactttgttgattacaaa
acagatgcttttaatagaagaaaaggtatgagtgatgaagaaatagggaatcagctcaaa
gaaaaatatcagatacaaatgacgtattatcgaaatactttagaaaccatacttaaacga
cccgtaaagggttacttatattttttcaaatttggtacattagaaatagatgat
444.
miptkphdviwtdaqwqsiyakgqdilvaaaagsgktavlveriiqrilrddvdvdrllv
vtftnlsaremkhrvdkriqeasfkdpnnehlknqrikihqaqistlhsfclkliqqhyd
vldidphfrtsseaenillleqtiddvleqhydkldphfielteqlssdrnddqfrsiik
qlyffsianpqpfewlnqlaqpykeenkqqqlmqlindlamifmkagyeelqksydlfsm
mesvdkqlevietermfitkaiegkvlntdvitqhefmsrfpainskikeanegmedaln
eakqhydkykslvmkvkndyfsrnaedlqrdmqqlaprvaylaqivqdviqsfgvqkrsr
nildfsdyehfalriltnedgspsriaetyrehfkeilvdeyqdtnrvqekilsciktge
ehdgnlfmvgdvkqsiykfrqadpslfiekynrfsssgnesglridlsqnfrsrqevlst
tnylfkhmmdeqvgeisyddaaqlyfgapydevshpvqlralveassensdltgseqean
yiveqvkdiinhqnvydmktgqyrkatykdivilersfgqarnlqqafknndipfhvnsk
egyfeqtevrlvlsflrtidnplqdiylvglmrsviyqfteeelaeirvvsphddyfyqs
iknymidekadsrlvdklnrfiqdiqkyqnysqsqpvyqlidkfyndhfviqyfsgligg
kgrranlyglfnkavefenssfrglfqfirfidelidrkkdfgeenvvgpndnvvrmmti
hsskglefpfviysglskkfnkgdlnapvilnqqyglgmdyfdvnkdmafpslasvayra
inekeliseemrliyvaltrakeqlilvgrvkdekslikyeqlavsdthiavnerltatn
pfvliygvlakhqspslpndqrferdidqlnsevkprvsividhyedvsteevvndneir
tieelkaintgnedvkikihqqlsydypfkvntmkpskqsvselkrqleteesntnydrv
rqyrigvasyerpkfltqtkkrkaneigtlmhtvmqhlpfreqrltkdelfqyidrlidk
qlidedakedirideimhfidgplymeiaqadnvytelpfvvnqikvdgltsededvsii
qgmidliyesdgqfyfvdyktdafnrrkgmsdeeignqlkekyqiqmtyyrntletilkr
pvkgylyffkfgtleidd
445.
ctgtaccatcaaatggtgctacaatttctcctgaatctggtacaaatccgataccatcac
ccatcatcttttcagagaaaactttatcaggtacttcagataacggtattatctcaccat
gtccaggtgcgtaaatttctgtttctacaatatcttccacatgtacaggatcatctgaca
cttcttcatcaattgttgtttcacttggttttg
446.
lyhqmvlqfllnlvqiryhhpssfqrklyqvlqitvlshhvqvrkflflqylphvqdhlt
llhqllfhlvl
447.
cgcatactttggtcatcactatgcgtaatccacaaaatggcaatccctttatctgctagt
ttaaatataatttcttcaattttctttttattatgtgtatctaaagcgctagtagcttcg
tccaataataaaacttcaggttcatacatgagttgtctagcgatggtaatacgttgttgc
tctcccccagacatgtgctcaatt
448.
rilwsslcvihkmaiplsaslniissiffllcvskalvassnnktsgsymsclamvircc
sppdmcsi
449.
tcacgtactttacgcgctctactcttaatactccaaacaggcatgatgtgtggtttgtta
tggtcatcatctgaaatcataataaaattcttttcacctttgtttgtcaatccgtatact
tcgtcatattttgcgacatctttaataaactctctcattcttatatcatctaattcagac
atcaactcatcagtcattttaactatatctacaatgtttccttcttcaccattattcaca
ttaactaaaactttgtcacctggatcaaagatttcatccatttcatatgttacaaaacgg
tcaatatctgctctaatgattttgtcg
450.
srtlralllilqtgmmcgllwssseiiikffsplfvnpytssyfatslinslilissnsd
inssviltistmfpssplftltktlspgskissisyvtkrsisalmils
451.
gcaggatttttgactaaagcagtacttaaatcaacttcatctctgtcatcaaacacttct
tctacgacttctttacgtgcaatcactctaaatgaaccttcgtccatatttaattctact
cttacatttctggcactatca
452.
agfltkavlkstsslssntssttslraitlnepssifnstltflals
453.
tatttctttataagctttttaattagactaatatcatgctcattgattaccgaaacaatt
tcgatttgtccatttttagatataattgagccattaccaccaatcaaggtatcatccgca
aattcaggaatgactggaagcaagtctctaatgggacgtgctgatgcaaacattacattg
454.
yffisflirliscslitetisicpfldiieplppikvssansgmtgskslmgradanitl
455.
ttatcttcttctaaagctttaccttcaacgtcaacgtttggcaatactgcacctaaccat
ttaggaaggtaccatgaagctttaccaaagagtttcgtcaatgctggaattaatgtcata
cgtacgacgaatgcgtcgaataacacaccgaaacctaatgcgatacccattgacttaatt
gcactgtcatcttggaagacgaatgcgatgaatacactgaacataataagtgcagcagct
acgataacaggtccactttctttgatacctacacggattgaa
456.
lssskalpststfgntapnhlgryhealpksfvnaginvirttnasnntpkpnaipidli
alsswktnamntlniisaaatitgplsliptrie
457.
tcatcaactgcttgcattaagtctaagattttttgttcgtattcagcatcgccttctaat
gcttttaatgcagaaccagcgattacaggtacatcgtcacctgggaagtcatattcgctt
aataagtcacgaacttccatttcaactaattctaataattcttcgtcgtctaccatgtca
actttgtttaagaatacaactaatgctggtacaccaacgttacgtgataataagatgtgt
tcacgagtttgtggcattggaccgtcagcagcagatacaactaagataccgccgtccatt
tga
458.
sstacikskifcsysaspsnafnaepaitgtsspgksyslnksrtsistnsnnsssstms
tlfknttnagtptlrdnkmcsrvcgigpsaadttkippsi
459.
ttagaaccacctacacgacgagctttaacttctaatactggcatgatattattaattgct
tcttcgaacacttctaatgcatcacgaccactacgttgttcaacaagatcaaatgcagaa
460.
lepptrraltsntgmilliassntsnasrplrcstrsnae
461.
aggaggcgaccgccccagtcaaactgcccgcctgacactgtctcccaccacgataagtgg
tgcgggttagaaagccaacacagc
462.
rrrppqsncppdtvshhdkwcglesqhs
463.
tgtgctattattccccctattgaaggacctaacccttcacctaaagctacaattgatcct
ataaaaccaaaggctttgccttgtttttttcttgtaatatttctagctacaaccaccata
atcagtgaagggaatgcagcagatcctactccttgtactaacctaccaaaaatcaaaata
aaaaag
464.
gccagtcacttctcgttccatttgattcaatacaaacaaattatcttgaacatcttccga
agcactgtcgccagtatcttgcttttcttttgcttgttgtttatgatttattttcgcacg
gtcaaattttttcttaactttctcattattaatgatttttgcttttacatggcattcaac
cggaaaaggcatattttgagctttctcaaa
465.
tgtcgtattaatactgccttcaccagtattgctagcatttggatcttgagtttgtgcgtt
tgctgctacaggtgctgctggttgcgctgctgctggagcattcgctggctgtgtttgatt
tgccggtgttgcattattattaggtgttgcttggttatttccttgacctgcttggtttgc
cggtgttgcttgatttccaggttgtgcttgtgcagcgttattcggatcagcttgattacc
ttgtccagctggttgtgtatttggttgtgctgctcctcctgctggattagcctgtccacc
ttggtttgctggttgtactgctggttgtccttggttggcaggtgcagctggctgtgctgt
aggattagcttgagcaccagcatttgcgttaggctgtgtattggcatcagctggttgtgc
tggttgattttgtgcaggctgattttgctctgctgcagacgctgttgtcgggttagtaga
tataaaagtaacagtggcaat
466.
atccaacgtttcaggaataaatgttttcaaaccactttgaaatggatcgcggtgttgtgc
ttgatatactttgtagcgataacgtttacctacacaatcataacgacaatgaaaatcgtc
atcgactgtaactacattgttgacataaatatcatcagg
467.
cggtataaaggtaaagcaaaatgcatcagcttgcttagaatgattgtcctttttttgata
atagcgttccattgcaatgacggcagaaggatggtttgcaaacaaatgatttgtatattc
actttc
468.
atgcaagagtaccaaaaatcgttaaatacgcttaaaaagcctataaatgttccgtatgag
caagaaactgaaaaagtaggtggtttatttagcaaagaaatacaagaaactggaaatgtt
gtaataagccaaaaagatttcaatgaatttcagaaacagataaaagctgctcaagatatt
tcggaagattacgagtatataaagtctggtagagccttagatgataaagataaggaaata
cgagagaaagatgatttattaaataaagcagttgagcgtattgaaaacgcagacgataat
tttaaccaactttacgaaaatgcaaagccacttaaagagaatatagaaatagcgttaaag
cttttaaaaatcttactaaaagagttagaacgagttttaggaagaaatacctttgcggaa
agagttaataagttaacagaagatgaaccaaaactaaatggtttagcaggaaacttagat
aaaaaaatgaatccagaattatattcagaacaggaacagcaacaagaacaacaaaagaat
caaaaacgagatagaggtatgcactta
469.
atgctaactactttcgctgttgtactcattttcttcttacttccatcttcatttttattg
470.
ttgagcatctgcatcattattatcattcatgcgatcatttttgttcacattattaaaaat
ggcattcaaaataacaat
471.
ttgcctataccaagtactagaagtgcaccaataattccagcaatcaatgcaacgatgact
gttttaaaccatggaaatttaggtcttctgtatctaggtgtttggctatggtttgttgta
gaa
472.
atgcttttgagttacttcataatactcatcagttttttgtgtatccttttgacttttatt
tatttctttccacttaccagtatgactttctttttttacagttattttcggtttgtt
473.
atgacttgtgaaaaactggaaaatttcttgaccagtagcaaagccggcaccaacgacaac
accaacaaaggcaaatgccacaataatggactcttt
474.
ttgattgtcattagtaacgttattgccattattttgatttttatctgttttgtctgcact
atcatcttgttgatcattttcttcggtttctgtctttttatgcgtagatttattttcttg
ttcttggttattact
475.
atgtgcagaaattgcccagcattcaccagttgtttcattagggatatcatagttaaatgc
ttt
476.
gtggtatacaacgcaacgtatatgcatcttgtacacgtatttctgattgtcgcgtcgtta
atgttgatccttctaaccaatcacgcatacgcgctgccacat
477.
gtgacaaatatcacactaaacagtgcatttgcagatgctacgataagcgtatttttatac
caagtcaggtat
478.
ttgtgcagtagtagcttggttactattcttaagcttttgttctgcatctctcaactgttt
aagtttttgatacgcatcttgtttacgttgatttgtacgtttatattgattttcagcttt
tttaagttctgtattcga
479.
ttgccttcttgtttatattgttcaacaagtgctttatgcttagcggactgcttctgtact
gcgtcacttgctctttttagttgtgcagtagtagcttggttactattcttaagcttttgt
tctgcatctctcaactgtttaagtttt
480.
caiippiegpnpspkatidpikpkalpcfflviflatttiisegnaadptpctnlpkiki
kk
481.
ashfsfhliqykqiilnifrstvasillffcllfmiyfrtvkfflnfliindfcfymafn
rkrhilsflk
482.
crintaftsiasiwilslcvccyrccwlrccwsirwlclicrcciiircclvisltclvc
rcclisrlclcsvirislitlsswlciwlccsscwislstlvcwlycwlslvgrcswlcc
rislstsicvrlcigiswlcwlilcrlillccrrccrvsryksnsgn
483.
iqrfrnkcfqttlkwiavlcliyfvaitftytiittmkividcnyivdiniir
484.
rykgkakcisllrmivlfliiafhcndgrrmvckqmiciftf
485.
mqeyqkslntlkkpinvpyeqetekvgglfskeiqetgnvvisqkdfnefqkqikaaqdi
sedyeyiksgralddkdkeirekddllnkaverienaddnfnqlyenakplkenieialk
llkillkelervlgrntfaervnkltedepklnglagnldkkmnpelyseqeqqqeqqkn
qkrdrgmhl
486.
mlttfavvliffllpssfll
487.
lsiciiiiihaiifvhiikngiqnnn
488.
lpipstrsapiipainatmtvlnhgnlgllylgvwlwfvve
489.
mllsyfiilisflcilltfiyffpltsmtfffysyfrfv
490.
mtceklenfltsskagtndntnkgkchnnglf
491.
livisnviaiilificfvctiilliiffgfclfmrrfiflflvit
492.
mcrncpaftscfirdiivkcf
493.
vvynatymhlvhvflivaslmlilltnhayalph
494.
vtnitlnsafadatisvflyqvry
495.
lcssslvtilkllfcisqlfkflirilftlictfilifsffkfcir
496.
lpsclycstsalcladcfctaslalfscavvawllflsfcsaslnclsf
497.
caagtgctgaaaatgcttcagaacatcctcttgctgatgctattgttacttatgctaaag
ataaaggtcttaatttacttgataatgacacttttaaatcaattccgggacatggtatta
aagctacgattcatcaacaacaaatccttgtgggcaatcgaaaat
498.
aagaggcttgttatgcagcaacacctgcaattcaacttgccaaagattatcttgctcaac
gccctaacgaaaaggttcttgtcattgctagtgacacagctcgttatggtattcattctg
gtggtgagcctactcaaggtgccggtgcagttgcaa
499.
ctgcgcctacgccagtttcagctattatgcacgctggtattgttaatgctggtggcgtta
ttcttacacgcttttctccggtatttaatgacgaaa
500.
cgtttacgatatacttcatacatcattaaacttgcagccacagacgcgttcaagctattg
acatgtccaaccattggaatcttaata
501.
tcaagcgtttttgctatacgacttactatcactttttctcgattttcaaatgttggatgc
aaaaaacatatcaagggagccataataatgaagaaagaaataatagaatggattgtagcc
ataatcgttgcaattgttatcgtcacacttgtgcaaaagtttttatttgcttcttataca
gtcaaaggagcatctaatgtcatttatcac
502.
agatctgtaccacatattgtcgtcttaactatgcgaataatagcgtcagtactgctcgta
atagttggcttctctttatccgtaagttgtgca
503.
actgccaataatatcatcagcttcataattacgcttaccaacatttacaaaaccaaactg
atgggatatttctttaacataatcgaattgaggaataagttcatcaggaggtgctgggcg
attttgtttatagccatcatacatttcatttctgaatgtttcttgccccatatcccaaca
aactgctacgtgagtaggttcgatttccttgatagcgctaaaaatatgtcttacaaaacc
ttgaataccatttgtaggaattcctttagaattgtacataaattgattgtg
504.
ttcttttgtagattgactcaactcaactggctcaaatacttgtccgttagaatgctttac
atgtattttatgattttcagtataatgaatcatattgtaagtaccatttgt
505.
atttttatatctacatgcgggtgtagtacaacatcagcttggaaggctgaggttttgcca
ttaagggttcgattcccatcacccgctccattt
506.
ctaaagaatatattgaggattgtatttattgctggtttgacagttttcttctctggtcct
ggccaaacttattcaaacgcagcatttattgatgaatatattcaaacatttggatggagc
cgtacagaagtt
507.
aggaattccaatcaaatgtaccaaacatttacagcggatattgtacttatatttatgatt
attgtacttggaggacttgtagttcaagttccaatgccaattttagcaggtattatggtt
atggtttctgagacaatctactgtttgcacctgat
508.
aatcaacgactcgaggaaacaatttcctctccccatcacagctcagcctta
509.
atgaaacaatttttaaacatcactcaacgtaaatttatcgaatggttgattatcttatcc
atttttatagttagcattcctaataaatggacattaatgatatctatcgctttatcttta
ttacttcttaaaagaggggcgctaggtgtcgttcaattaatcatactttatatgctcaga
tcgcaaatatacaccccatatgatacacaagagatggcgcattacatagtaagtatgaaa
tatatcttgatttatgtaattggagtattttttctatttaaatatgtaaaacattggata
agaaatgaaatgatattaagatttatcaagtctactatgattcttatgctactttatatc
ataatgagtttagtcgtatctaatgatccgatagaatctattcttaaattgcttaacttc
tttataccgctaattttgattgttatgtatgttagtttaataaaaaagataaagaatctc
attaactggattaatcaatttatcacgctagtgattgcctttacttttttatttatagtt
atagcgccaaaatcatatttaattgatgaggaatcacttagaagtgttttcaaggatgca
cattcattcgcagttattcttgctatgggtctagttctatatatggtaacaataatcaaa
caacaagattatgatgtattcaatttattattattaaatattggaatgatagagctctat
ttatcaaattctcgtcatattttcatatctgttattttatgtctaatgcttctattaccg
ttatctcacataaaaaagagaattaaacatcccataattggtgctatgatactaatggca
attgctataataaatcaaccatatatttatcatctttttattaaactaatcttaaaaggg
aagaatagccaagaggtctttatgccgagtgatatgaatattaaagctattgattatgcg
ctaactgagcatccttttttaggaagcggttttggtataccaatgataaaagcgagttca
gaaatacaatactttaatgtagcaacgagtaatatcatcttcggtatgattatctttact
ggaataataggacttactttatgtacgatatacatgcttcatatggtacttttagttact
tttccaatgagtattactattttattatttttaatcactatctttgttaatatggattat
attattttatttgattccgtggggctaggtatattgtgttatatattttggggaatatat
ttaaaagaaggtatgtatcaatacaacaacggacaatgg
510.
atgacaaatcaaaaaactgtgggtctagtcgtcgctccaggtgttactgaacgccttgca
gaaaatctcatacaagaaatgcctaaaatgttatctacacattatgatcatcagcaagaa
tggatttttgatttagttacggatccgcttactggttttgctgaatctgtagatgaaatt
tttgggaaagtagccgattatcacgataagagacaatgggattatgtgatagcaattaca
gatttaccgatgtttgcggacaagcaagtgatggcattagatattaatatggaaaatggt
gcagctatattctcatatccggcatttggctggcgtccagttaaaaaacgtttcaagcat
gcgatttataatattattcaagaattaaatgaagctgaacaagaaagtcgtaattatgat
aataataagcaaatagaaaattcagtaaaaaaacaatttccgctctctaaaatagataaa
gaaacaatatatatgaaagaaacagactcttatcacttaagatatttatcaagttcacgt
tctagaggcatgtttcgccttgttagtggaatgacctttgcgaataatccattaaatatg
atggcaagtttaagtaatatagtagctattgcatttactacaggtgcatttggacttgta
tttacaacgatgtggcaaatggcttataacttttcaatgtggcgcttatttggaatttca
attattgcgattattggaatgctaatatggataatgatgtcacatgatttatgggagcca
gttaataaaagcaaccataagcatattacttggttatacaatcttacaacaataatgaca
ttgatttttgccattataatttattatattattctttatttactattcttaattgctgaa
atcgtattattgccatcaggattcttaggtcagcaagttggattgaaaggtcctgcaggc
attgatttgtatttaagtattccatggtttgcagcttcaatttctacagttgcaggtgca
ataggtgctggtttacttaatgatgaactcattaaagaaagcacatatggatatcgtcag
cgtgtaagatacgaagaacaacgtcga
511.
atgaaattctgccctcattgtggaaatccgataaaaaaggaacagtcattttgtaataaa
tgtggaaaacatttaaagacatcgacacaaagaaaaagtgaaaatcaaattgaacatatg
cgtgaacagcaatcgtatatttctcgtgaggaaagacaacatcatgattcaacattttat
aaagaacaaaaacatactggttggctaattgtattatcaattatatttgtcttgttgata
gcagcgctattgtatggtgcgtactatgcttacaatcattatattagtgatgagcaaagt
caccaaacaacagagtctcagcaatcaaatgaaagtgatcaaaatagggaccaatccact
ggtccaagcattgatgtttttagtgatgactttgatcaaggttatatgaagtcagcttca
acaagtggatatagaggtgtttataatggaatgacacgtgaagaagttgaagataaattt
ggaacatccaatggttctgtagaaagtttgaagtggagttacgaaacatatggtgattta
gctgtagcctacgatgataatgaagttgttagcgtaggtgtagcacctaatcatatttca
gaagatcaatttttaagtatgtataatgaaccggatgatagaaattcaagccaactcatt
tatgatagtaacaaagataatgacttctctgtgttagctaatgttaaaaatggagatgtt
actgtcattgaaaatgtaaatcaaatt
512.
atgttattgtttatcatagaaatcataatcatgattctagcgatattattaggattaaga
actgctggtgcactgggatgtggcatctttgctatagtagcgcagcttatcatgatattt
ggattccagttacctccaggttcagcaccagtgacggcagtgttaatcatattatctatt
ggtatagcaggtggtacgttacaagccactggtggtattgactatttagtatacattgca
tcacgtgtgattgaacgctttccaaaatcaattatatttatagcgccaatgattgtcttt
gtctttgtttttggaattggtactgcaaatatagctctttcacttgaacctatcatagcg
aaaactgcacaaaaagcacgaattcagcctaaacgcgcattaactgcttcggtacttaca
gccaatttagccttactttgtagcccggcagcttctgctacagcttatattatttctgta
ttagcagggtatgaaatatcgatgggcaagtatttaagtattgttttacctacagcttta
attagtatgttaatgcttagtacattttgtacatttgtaggacgaaaagaacacgtgcgt
gatgagtcagaacgtttagttcagatgccagaagtcgaaatcaaaaatgacttttcatta
aaagtaaaaataggtgttatctcattcctattatgtgtcatgggtattttaacgtttggc
atatttcctaatctcatgccgcaattcaatgtgaatggagatgtagttaaagttgagatg
actgaaattgttcagttctttatgtatctcagcgctacaatcaatttattattaataaaa
atcaatacttctgatattctgtcatcgaatattacacaatctgcaatgggagcacttttt
gcagttcttggcccaggttggttaggtgcaacaatatttaatgctccacataacttaaaa
atattgaaaaatgatattgggtcaattattagtgaagtaccttggcttgttatcatactt
gtttctgtagttgcaatgattgtcatttctcaaacagctacagcatcaattatggtgccg
atagttatgagtttaggtatacctcccatctattttgttgcgatggtacaaacattaaat
gtgaatttcgttattccagctcaaccgacactattatttgctgtagaactagatgaaaca
ggtagaacaagacctacgagctttatgataccaggattttttgttataacagtatccgtc
attacaggatttgttattaaaaccattttaggatat
513.
atgggaagtttttttaatcggatgactcgaaaagagaatcctactatttatcaaaataaa
gatgggcatcttaagcgcacgttacgtgtacgtgactttcttgcactaggtgttggtaca
attgtctctacatctatcttcactttaccaggtgttgtcgcggctgagcatgccggacct
gctgtggcattatcattcttattagctgccattgttgcaggtcttgtagcctttacttat
gcagaaatggcatctacaatgccttttgctggatcagcttattcatggattaatgtactt
tttggtgaattattcggatgggttgccggttgggcgcttttagcagaatactttattgct
gttgctttcgttgcttcaggcttttctgctaacttaagaggtcttattgcaccattaggc
atttctttacctaaatcattatctaatccatttggaagtaacggtggtgtcattgatatc
attgctgctgtagtgattattttaactgcattactattatcacgcggaatgaacgaagcc
gctcgtatggaaaatgtattggttatattaaaggtgttagccatcattttatttgtgatt
gttgggctaactgcgattaatttcagtaactatataccatttattccagaacataaggtt
actgaaactggcgactttggaggttggcaaggtatttatgctggagtttcaatgattttc
ttagcttatattggttttgactctattgctgctaattcagctgaagcgattaatccacag
aagacaatgcctagaggaattttagggtcactcatagtagcaattgtattgtttgtggcc
gtagcacttgttcttgttggcatgttccactactctcaatacgctgataatgcagagcca
gtaggttgggcattacgagaaagtggtcatggtattattgctgcaattgttcaagcaatt
tctgtcatcggtatgttcactgcattaatcggtatgatgcttgcaggttcacgtctatta
tattcatttggacgagatggtttactcccttcttggttaagtcaattgaatcacaaacat
ttacctaatcgagcacttgtcatacttacaatcattggcgtagttatcggatcaatgttc
ccgtttgctttcttagcacaattgatttccgcaggtacccttgttgcattcatgtttgtg
tcactagcaatgtatcgattaagaaaacgtgaagggaaagatttacctaagccagagttt
aaattacctttatatcctattttgcctgcaattacatttatattagtattgctagtattt
tggggattaagttttgaagctaagttgtatacactgatatggtttattgtaggtataatt
atttatttaatttatggaattagacattccaaaaagaatgatgaagaagcgtatcaagta
cctagagaa
514.
atgacaaagaaaaaacgtttatcgcctagtgagtggttgcttaaacaatctaaaagacat
aaaaggaaaaatacactttacacggcaattgtacttttagtagcgttagttctactcata
tttgctgttaaatcaatacaagtagaacctgtaaaaagtgatacgagagacaaagatagc
attcgtatcacctatttaggtaacgtcactttaaataaacatattcgacaaactaacttg
aatgatgtttttaaaggtattcaagatactttagatcatagtgatttttcaacaggttca
ttaatagtaaatgatttttcaagaaatcaaaaagataacataaataaaaatattgaaaat
atcatgtttctacgcaagcataatgttaaaagtgttaacttaatcaacgaatctatggat
aatattcaagcgacagcaatgatgagaaaaatagattcccaagcaggttataatttttta
acaggtaatggttcaaatccaattaatagtaaaactgtacaacaagacattaaaggtaaa
aaaatagctaatgtttcatttaccgatatcgaatctaactatactaactctttaaaaaac
acgacgtcaattagtttagatccagctatattttatcctttaataaaaaaattaaaggaa
aataatgattacgtcgtagtcaatgtagattgggggatacctaatgaacgaaatgtgact
acacgtcaaaaagaatatgcacatgcgttagcgaatgctggtgcagatgtcattattggt
cataatacagttattcaaaaagttgaaaattataagcgaacgcctattttttatagttta
ggtaacacaacgtctgataacttcttatcaaaaaatcagaaaggaatgattgtacaacaa
gactggaaaggttcgcataatcagttccatatcacaccaattcaatcaaaagatggaaaa
atctctaaagataatatgaataaaatggatcatattcgattcaaaaataacattaaagat
aaatcaattgatttaaaatctgatcaaaatggaggttatacttttgaatat
515.
atgattgaacatttaggaattaatacaccttattttgggatattagtatcattaatacca
tttgtcatagcgacttatttttataaaaaaacgaatggtttctttttactagcaccttta
ttcgtaagtatggttgcaggtattgcttttttgaaattgacaggaattagttatgagaat
tataaaatcggtggcgacattattaatttcttcctagaaccagctacaatatgctttgcg
attcctttatatcgcaagcgcgaagtattaaaaaaatattggttacaaatatttggtggt
atagctgttggtacaattattgccttgttattaatttatcttgttgcaataacattccaa
tttggcaatcaaattatagcatctatgctacctcaagctgcaacgacagcaattgcatta
cctgtatctgacggtatcggtggtgtcaaagaattaacctcactcgcagttattttaaat
gcagttgtcatttctgctttaggtgctaaaatagttaaattatttaaaatatctaaccct
attgccagaggacttgcactagggacaagtggacacactttaggtgtcgcggcagctaaa
gaattgggtgagactgaagaatcaatgggaagtattgcagttgtcatcgttggcgttatt
gttgtagcagtagttcctatacttgctccaatcttatta
516.
atgaaaagaacagataaatatagagattcatacaaatatgatgaccaatatcaaaatcat
cgtaaacgttcagaagaagatatgtatcgacaacatcaagagtcccaacagagagcaaat
tcaaatcgtgcaacacaaagtgaaaatgatagagagtatgaaaatcatcctgaacgttat
tacaatggaagagactatcgacgtgagcagcaattggaagaagaaaatgaaaaatcaagc
aaaactaaaaaatggctgattgcaatcatagttattttactcattattgtagctatcttt
atcacgcgtgcaattatcaatcataataatgataaagtaagtaatgaccctaacgtttca
caaaactataaaaaggaagttgaaaatcaaaacgacgacattaatcgacaagttgattca
gccaaaagcgatataaaaaataaaaaggacacccaatcccaaattgataaactacaaaat
caaattgatcaattaaaacaaaatgaagaaactaatgcggattctaaattcacaaaattt
tatcaaaaccaaatcgacaaactgaaaaatgcaaataacgctcaacttaataacgaaaat
caaagtaaagttaacaacatgcttgaagacatcaatacaaaatttgatagtattaaagct
aaactagaaaatatcttgaatggatcaaattcaggaaac
517.
atgaacatgaaaaagggtgtttctcagcttacgttacagacattgagtttggtcgcaggc
tttatggcatggagtatcatttctccattaatgccatttatttcacaagatgttgatatt
tctccaggacaaatatctgtcattttagctattcctgttattttaggttctgtactacgt
gtaccatttgggtacttaactaacattgtaggagcgaaatgggtgtttttctggagtttt
attgtactattacttccaatttttcttttaggtcaagctcaatcacccggtatgctaatg
ttatcaggattctttctaggaattggtggcgcaattttttcagtaggtgttacttcagta
cctaaatacttttcaaaagacaaagttggtttagcaaatggtatatatggtgtaggtaat
attggtactgcagtttcatcattttgtgccccagtgttagcaggtgcaattggctggcaa
aatacagttcgtagttatttaattattctaagtatatttgcaattttaatgtttttttta
ggagataaaaatgagccgaaagtgaagattcctttgatggctcaagtcaaagacctatct
aagaattataagttgtattatttaagtttgtggtattttattacttttggagcttttgtg
gcttttgggatttttttaccgaactttctagttgatcattttagtattgataaagtggat
gcaggtattcgttcaggtatatttatagcactagcgacgttcttaagaccggttggtggt
gttataggtgataaatttaatgcagtacaagcgcttatcatcgacttcgtgataatgatt
attggtgcgcttatattaagcttatctagtcatattgttctgtttacgataggctgttta
gcaattagtatctgtgcaggtataggtaatggtttaatatttaaattagcaccttcatac
ttttctaaagaagcaggttcagcgaatggtattgtatccatgatgggaggactaggcggt
ttcttcccaccactggtgattacttttgtaacgagtatcactggttcaagtcatctcgct
ttcttcttcttggctatatttggtgtaattgctcttattacaatgattcatttaaataaa
aaagagaaagctattcgtata
518.
atgaaaaataaaaaaggattaggcataggtcttatcacaattatgattatcgtttgtatt
gtactagtaatcatgatgttcgtgggtggtaagaaagaatcatactacggtattatgaaa
gatagcacgactattgataaaatgataaatactaaaaatgaaaaaattgaaaaaaacgta
gaattacctaaagatgctaatgtatcagttaaaaaagaagattttgtgatgctctttaaa
gatgaaaaaactggaaaaattactaaagttaagaaagttaatcacgatgacgtacctcat
ggtttaatgtcaaaaatccatgatatgggtaatatgaaacacggaatg
519.
atggctatgtcattactcgtgagtcttgtggtttatatgatgacactcacatctgatata
ttagaagatattctatcatttaaattagaagtgataatgcaatttccgtatatattaagc
tctatttcactaatcattttgtttatacttttcattttaaaagatatggaaaaaatatgg
tactggctcatttcaatagttatgattgctgtgataagtatgtctggacacgtgtggtca
caacaagtgccattatggtcaattatcataagaacaattcatcttatagggctaacgtta
tggttaggttcactcgtttatctcatttgttatgctattaaagtgaaaattaatcagttg
acgagtgtaagacgtatgcttttaaaagttaatatcattgctgtgattatgctcgttttt
acagggattttaatggctattgatgaaacgaatactttaacactttggaataatgtgagc
gcttggtctatttatcttgtcataaaaatcgcaggaattattgctatgatgctattaggt
ttctatcaaacgatgcgtgctttgagacaacgacaacaggtccatcgttttgcactgatg
actgaattgttaattggtatgatattaattttgcaggtatca
520.
atgaaaaactctagattttctgggttccaatgggctatgatggtctttgtatttttcgtt
atcacaatggcattgtccgtgatactcagagattttcaagcgactatcggagtgaaacgt
tttgtctttagtattaaagatttagctcctttcatagctgcaattgtgtgcatattagta
tttaagcacagaaaagaacaattagcaggattgaaattttctatcagtttaaaagtgatt
gagcgtctacttttagcactcattctaccacttatcattttaatgattggcttgtttagc
tttaatacttatgctgatagtttcatcctattacaaacttcagatttatcagtatcatta
ttaactatattaattggtcatattttaatggcttttgtagtggagtttggtttccgttct
tacttacaaaatattcttgaaacaagaatgaacacattttttgcgagtattgtcgttggt
cttatttattcagtatttacagctaacacgacatatggtgtagaatacgccggataccat
ttcttatatacattcatgttttcaatgattattggtgaattaattagagctactaatggt
cgtacaatttatattgcaactgcttttcacgcatccatgacttttgctctcgtcttttta
tttagtgaagaaacaggcgaccttttctcaatgaaagtcatcgcactttctacaacaatt
gtgggtgtttcatttattattattagtctaatcattcgtgctattgtttataaaacgacg
aaacaaagtttagacgaagttgatcctaataattatttatctcatattcaagatgaagaa
ccaagtcaagaagacgcctcttcaacttcaaatcatgatgtatcatctaaagatgaaaca
aagcaacaagatattgataatgacaaacatcaatcaaagaaacctaataagagtgacgat
gcacttactacttctaattataaagaagacgcctcttcagttaataaagaaacggataca
actcacaatgataacattaaagatcattcaacttataccgaagatagacactcatctgtt
gtcaacgatgttaaagatgaaattcacgaagttgaagatcataaagccgacacagataaa
tcacat
521.
atggaaaataatgagttgcaaaggggattgaatgcacgtcagatgcagatgattgctctt
ggtggaacaattggtgttggtctttttatgggagcaacaagcacaattaagtggacaggt
ccatcagttattcttgcatatttaattgctggtatttttttatttttaatcatgagagcc
atgggtgaaatgatatatattaatccaaccactggttcttttgcgacgtttgctagtgac
tatattcatccagcagctggctacatgactgcttggagcaatgtatttcaatgggttgtc
gtcggcatgagtgaagtgattgcagtaggagaatatatgaactactggttcccaagcctt
cctaattggataccaggagtgatagcagttctctttttgatggctgctaacctagtttca
gtaaaagcgtttggagagtttgaattttggtttgccttaattaaagttgtaactattgta
ttaatgattattgcaggattaggattaattttatttggtataggcaatggagggaatcca
atagggatttctaacttatggtcacatggtggatttatgccaaatggattcattggattt
ttctttgctttatctattgtgattggatcataccaaggtgttgaattgattggcatctca
gcaggtgaaaccaaaaatcctcaaacaaatattgtaaaggcagtcaacggagtgatatgg
agaattttaattttctatattggtgcaatttttgtcattgtatcagtatatccttggaac
caattaggtagtattggtagtccttttgttgcaacgtttgctaaagtgggcattacgttt
gctgctggtttaataaactttgtagtcttaacagcagcattgtctggttgtaattcaggt
atttttagtgcaagtcgaatgatttatactttggcaaaaaaaggacaaatgcctaaagta
tttactaaagtaatgaaaaatggcgtacctttctacactgtatttgcagtatctatggga
atattaattggtgctttattaaatgttatacttccattaattattgatggagctgatagt
atctttgtatatgtatatagtgcctctattttaccgggaatgataccttggtttatgatt
ttatttagtcatctaagatttagaaggttacatcctgaaaaggttcacaatcatcctttt
aaaatgccgggaggggcaattgccaattatttaactatcatgtttttactcctagtatta
gtcggtatgttacttaacaaagaaactgtagtatcggttgttattggtatcgtgttttta
acagctgtgacactttattatcttattagatatcacaaaaaggaacgacaaata
522.
gtgaaaagacttaagaattttattctcggcttactcattgtggctatagttggcttccta
ttatttatgtatatagatgatagtcgcattcaaagttatcaagactacttcttacaattt
aattggttccaaccactattgattgggcttgcaggattacttatattaatcggacttata
ttagtacttagtatttttaaacctacgcatcgcaaacctggactttataaaaactttgat
gatggacatatttacgtatcacgtaaagctgttgaaaaaacaatttacgatacaatcgct
aaatatgatcaagttagacaaccaaatgttgtaagtaagctttataacaaaaagaataaa
tcatttattgacatcaaagcagatttcttcgtaccaaaccatgttcaagttaagagttta
acagagagtatccgtgctgatatcaaaagtaatgttgaacactttactgaaattcctgtt
agaaaattagaagttaacgtacgtgatcagaaaacatctggtccacgtgtattg
523.
ttgcaagattttgataacttaattcctggctggtttaaaacatttgttcaagtcgggaat
gacttaatttggtctcaatatcttattggattattattaacagcaggttttttctttaca
attagttctaaatttattcaactcagaatgttaccagagatgtttagagcattaactgaa
aagccagaaactttaagtagtggtgagaagggtatttcaccatttcaagcttttgcgatt
agtgctgggtcaagagtaggaactggaaatattgccggtgttgcaactgctattgttctt
ggtggccccggtgcagtcttctggatgtggattattgcttttattggtgcagctagtgca
tttatggaagcaacgcttgctcaagtttataaggtacatgacaaagaaggtggattccgt
ggcggaccagcctattacataacaaaagggctaaaccaaaaatggcttggaattgtattt
gctgttttaattacagttacatttgcttttgtatttaatactgttcaagcgaatacaatt
gctgaatcattaaatacacaatacaatattagcccggtaattactggaatagtacttgca
gttattacaggtattatcatctttggtggtgttcgtagcatagctacactatcttcactt
attgtgcctattatggctattgtttatataggtatggttttaatcattttattactcaat
atagatcaaattgtacctatgattggcactattattaaaagtgcattcggagttcagcag
gttactggtggtgctgtaggagctgctattcttcaaggtattaaacgtggtttattctca
aacgaagctggtatgggatctgcacctaatgctgctgctacatctgctgtgccccatccc
gttaaacaaggtttaattcaatcattaggtgtattctttgacactatgcttgtttgtaca
gctacagcaattatgattttattatattctggtttgcaatttggtgatagcgcgcctcaa
ggtgtagcagttacgcaatcagcgttgaacgaacatttaggttcagcaggaggtattttc
ttaactgtagcagttaccttatttgcattttcatctgttgtaggtaactattactatgga
caatccaatattgaatttttatctaacaataagatgatattatttatttttagatgtttt
gtagtacttttagtatttgtaggtgctgttgctaaaacagaaacagtttggagtactgcc
gatttatttatgggtcttatggcaatagtaaatatcatatcaattataggtttgtcgaat
attgcgtttgcagtgatgaaagattatcaaagacagcgtaaagaaggtaagagacctgtg
tttaaacccgaaaacttagaaataaatttatttggcattgagacttggggacaacatgca
aaaatgccaaaaaaa
524.
ttgaaaaaagaaattttagagtggattgttgccatagccgttgccattgcacttattgcc
ataatcactaaatttgtcggaaaatcatattctattaaaggtgattcaatggatcctaca
ttaaaagatggggagcgtgtagtggtaaatattattggctataaattaggtggcgttgaa
aaaggaaatgtcattgtatttcatgctaataaaaaagatgattatgttaaaagagttatt
ggaactccaggagatagtgttgaatataaaaatgatacactctatgttaatggtaaaaag
caatcagaaccatacttgaactataatgaaaaacgtaagcaaactgagtatatcacaggt
agtttcaaaacaaaaaatttaccaaatgctaatcctcaatctaatgttattcctaaaggt
aaatatttagttttgggggataaccgtgaggtaagtaaagatagtcgttcattcggttta
attgacaaagaccaaattgttggaaaggtatcgctcagatattggcctttcagtgaattt
aaatctaactttaatccaaataacactaaaaat
525.
atgttcaataaggtttggtttagaacaggaatattttttattatgctgttcatactcatc
aaactatttatggaagtgcatgaagtatttgctccaatagctactatcattggttcagtc
ttccttccatttttaattagtggatttctcttttacatatgtttaccttttcaaaacata
ttagaaaagtggggctttccacgttgggctagtataacaacaatattcataggattaata
gctatcatcgctattgtggtatcatttatagcacctatcattatttccaatattaataac
ttaattaaacaaacaccatcattacaaaaagaagccgaacaattaattaatttctcgtta
agacaaatggataaattaccagatgatgtcacacatcgtattaataaagcggttaaatcc
atgggagatggcgcaacgtctattttatctaattcagtgtcatatattacgtctttcatc
tcaactgtatttttattaataatggtgcctttcttcctgatatatatgctaaaagatcat
gaaaaatttatcccagcaatcggtaaatttttcaaaggagaacgtaaagtttttgttgta
gatttattaaaagacttaaacttcactttaaaatcatatattcaaggtcaagtgacagtt
agtatcatcttaggtattattttatatataggttatacgattataggattaccatataca
cctttattagtattattcgccggcgtagctaacttaataccatttttaggtccatggtta
tcttttgcaccggcagcgatactaggtattattgatggcccttcaacttttatttgggta
tgtgtcgtaacattaatcgcacaacaacttgaaggtaacgtgataactcctaacgtaatg
ggtaaatcattaagcattcatccattaactattattgttgtcatacttgcagctggagat
ttgggtggtttcacactcattcttgttgcagttccattatacgctgtaatcaaaacatta
gtgagcaacatttttaaatatcgtcaacgtattgtcgataaagcaaatagtaatgttaaa
gat
526.
atgaatacaatcgtaaaacatacagtaggttttattgcttctatcgtactaacgctttta
gcagtttttgtaactctatacactaatatgacattccatgctaaggtaactatcatcttt
ggttttgctttcattcaagctgcccttcaattattaatgttcatgcatttaactgaaggt
aaagatggacgtttacaatcgttcaaagttatctttgcaattatcattactttagtaact
gttatcggaacatactgggtaatgcaaggtggacactcttctcactta
527.
atgtcttttcttaggaaacacaccgaaattatatttagttatatcatcggtatcgtttca
ctttttacaggtctcattatttttattaacttacctttaatcaaacaatttaaaggtgac
aaaaaggttgatacgcatgtgcataacgtatgggaattcctaaatgccttttttgccgag
attataaaagtgatgagtaaatttattggtggctttccaattacaagtgccatagtaatc
atcgtatttggtattctagtgatgctgttaggtcacactttatttagaactattaaatac
gattatgacatttcaattttctttttagttattggcattatgtactttatcattacatta
ttgctaatgacacaagtgtatggcttttttgctatcgtctttattattccttttacagtt
catattggttacatagtttataaagatgagttgaaccaagacaatcgaaagaaccattat
atgtggattattgtaacttatggaatgagttatcttattacccaaatttcgctatatgga
cgtattgacgcaaatgaaattgaatcaattgatattttaagtgtaaatacattcttcatt
attatgtggttattaggtcagatggctatatggaatttcttattcctaagacgttcatta
ccactcactaaagaagaattaggcgaagaggaacctgaactttcaagaactaataaaggc
aatgtatctaatcaaactaaagttcacttaaaacaactacaaaataagacaaccgagtat
gcacgtaagactagaagaagtgttgatttagataaaattagagccaaaagggacaaattt
aagcaaaaaattaacagcatagtagatatacaagaggacgatattccaaattggatgaaa
aaacctaaatgggttaaacctatgtatgttcaattgttttgtggtgtaattattctgttt
tttgcttttctagaatttaataatagaaacgcattattcttaactggtgaatgggagtta
tcacaaacgcaatatgtagttgagtgggtaacattattattgctacttttcattattatt
atttatattgcaactacattaacttattatttaagggataaatattattatttacaactc
tttatgggcagtattttattctttaaatttcttacagaatttatcaatattatggtacat
ggattattattatcaattttcattacgccaatcttattattaatgcttattgcaatgatt
gttgcttattctttacagttgagagaaaaa
528.
atgttaggagagcaatatacacaaattaagcgtccagcaaatcggctaactgaaaaaata
ttaggttggtttagttgggtattcttactcatattaactattgtttcaatgtttattgcg
ctcgtatcttttagtaatgatacgtcaattgccaatttagaaaacacacttaataataat
gaactcgtacaacaaattttagccaataatgatttaagtacaactcaatttgtgatttgg
ttacaaaatggagtttgggcaattattgtttattttattgtttgtttgctcatctcgttt
ttagcgttaatttctatgaatataagaattttgtctggtttactttttttaatagctgct
atagtcacaattccgcttgtattgttgattgtaactctaatcattcctatcttattcttt
atcattgcaatgatgatgtttgctagaagagatagaatagaaacagtgccatcttattat
aatgaatatgatcaaccatactatgatgagagaggtttttatgaaccagagtcaagaaat
gaacatggatataatgatgatgtgtatgaacctatgcatactaaaaaggaagatagaaat
acaagacgtcaattcaatagaaatgctcagcaacaagattcctataatggtataactgat
aatcaacccgatgaagatacatcttccgatcaactttattcagacgaatatgtagataat
gaagataaatattctcaatttccaaaaagagcagttgaaagtgaatatgcatctcaacaa
actgaagatgaaccaacagtcatgtcaagacaagctaagtacaataaaaaatctaaaaat
acggattttgaagatgcgcaacaggaacatatggaaggtaatcaatttgatgacgtagga
gttgttgaaccacaaattgatcctaaagaactaaaagcgcaaagaaaaagagaaaaagca
gaaatacgtgctaagaaaaaagaaaagagaaaagcatataataaacgtatgaaagaacga
agaaaaaaccagccaagtgctgttaaccaacgacgtatgaattatgaagaacgtcgacaa
atgattaataatgaacaagaagatacagataataacttaaatcaacaggaagattcaaaa
aaagaaaat
529.
atggaagagaataaaaatcaacctaataatgagaatatgtcgaataaagacgataataca
atccatttgaatgatagtcaaagtaatgaagacttagagctttttagacggaataaaaac
gctcgccaacgcagaagacgtcgcatagataaccaaagtaaagaaaaagatgctacgtct
acacaatcacagttagaaactaaaccaatggataaatttattgataatcacaagtcgcat
aatcaagataaagaaataaaaagtgatttaattgaggataatgttaatgatgaagatgac
aatcaaaaatataataatgataaattaaatgatcgtagtgttcaacaaacaagcgaaacg
cgtcaaagtaatgaagacgaagaggaatttctaactgatcatcagagcgaaaaacaaact
aaagactctcgtcattctaaaaaacataaattactaagtaaatttacttctaaaaaagaa
aaggaaacatttacatcgttcaatagtaatgagaaggtaactcaaattaaaccgcttagt
ttagaagaaaaaagagccataagacgtaaaaagcaaaaaagaatccaatatacaattatc
acactactcattcttatcattgttctcattttactctatatgtttacaccactaagtaaa
atatcaaatgtaaatattaaaggtaataacaacgtaagtacgagtaaaataaagaaagaa
cttaacgttacttcacgttcacgaatgtatacttttagtaaaaataaagcgattaggaac
ttaaaacagaatcctttaatcaaagaagttgatattcataaacaattaccaaacacgtta
actgttaacgtgactgagtaccaaattgttggtttagaaaaaaataaagataaatatgtg
ccaattatagaagatggtaaagaattaacagaatacaaagatgaagtttcacatgatgga
cctatcattgatgggttcaaaggagacaaaaaaacacgaattataaaagctttatctgaa
atgtcacctaaagtgagaaacttaatagcagaggtgagttacgcaccaactaaaaataaa
caaagtcgcataaagatttttaccaaagataatatgcaagtcattggtgacattacaacg
attgcagacaaaatgcaatattatcctcaaatgtcacaatcattaagcagagatgattct
ggcgaacttaagacaaatgggtatattgatttatcggttggagcgtcatttattccttat
caaggttcatcaactgttcaatcgggtactgaacaaaatgtaaccaagtcaacacaagaa
gaaaatgatgcaaaagaagaacttcaaaatgtgttgaataaaattaataaacaatctaaa
gaaaataat
530.
atgaagtgtttgttcaaaatgctatcaatcataataataatgttaagtactttcacctta
ttcatcagtccgagtacatatgcaaatgaagatgaaaattggactaaaataaaaaatcga
ggagaactaagagttggattgtcagctgattatgcacctttagaatttgaaaagacgata
catggtaaaactgaatatgcgggtgtagatatagaattagctaaaaagattgcgaaagat
aatcatctaaagctaaaaattgtaaacatgcaatttgatagcttattaggtgcacttaag
accggtaaaatcgatattattatctccggtatgacaacaactcccgaacgaaaaaaagaa
gtggattttacaaaaccttacatgattacaaataatgtgatgatgattaaaaaagatgat
gcaaaacgttatcaaaacatcaaagattttgaaggcaaaaaaattgctgcgcaaaaaggg
acagatcaagaaaaaattgcacaaactgagattgaagatagtaaaatttcttcactcaat
agattacctgaagctatattatctttaaaaagtggaaaagtagcaggtgtagttgttgaa
aaaccagtaggtgaggcatatttaaaacaaaattcagaactaacattttcaaagattaaa
tttaatgaagaaaagaaacaaacatgtatagctgttcctaagaactctcctgtactttta
gataagctaaatcaaacgattgataatgtaaaagaaaaaaatttaattgatcaatacatg
acaaaagcagccgaagatatgcaagatgatggaaattttatttctaaatatggcagtttt
ttcattaaaggaattaaaaatactattttgatttcattagtaggtgtggtattggggtct
attttaggctcttttatagctttattaaaaataagtaaaattagaccattacaatggata
gcaagtatatacatagaatttttaagaggtactcctatgcttgtgcaagtgtttattgta
ttttttgggactactgcagctttggggttagatatttcagctttaatttgtggtactatt
gcgcttgttataaattcttcagcctacattgccgagattattagagctggtattaatgct
gtagataaaggacaaactgaagctgctagaagtttaggattgaattatagacagactatg
caatcagtagttatgccacaggcaattaagaaaattttacctgcattaggtaatgaattt
gtaaccttgattaaagaatcgtctatagtttccacaattggagtgagtgaaatcatgttt
aatgcacaagttgtacaagggatatcttttgatcctttcacaccattgttagttgcagca
ttactatatttcttacttacatttgcacttacacgtgttatgaattttattgaagggaga
atgagtgccagtgat
531.
atgcaacaagaaacgacatcatggtacaaacaagaatggtttatagttttatcactttta
ttcatttttccactaggtttatttctcatgtggaaatttagcaagtggccatctattgca
agaacaatcattactgttgcaatttcagttatcgtattagcaagcattacctattatggt
aatctacaaatgattgtaccagcaacatcaaattcaaataacgaaactaaagaaactaca
gagaataatgtaaatgataaagacgagcgaaatcataaaactgcagtagaagaaacaaaa
actaattatgactccaccaaagaaaatactaaagaacctggaaaagaaaatgaatctgca
acacgattggagaactctgcgcttgaaaaggcaaagtcatattatgatgattttcacatg
tctaaactaggaatttatgatattttaacatctgaatatggagaaaaatttgataaagaa
gatgcacaatatgctatagatcatctagaggctgattatgaaaagaatgcacttgagaaa
gcaaaatcatatgccaaagatatgcatatgtctaatgactcaatttacgatcttttggtg
tctaactacggtgaaaaatttacagaatcagaagcaaaatatgctattgagcatttggat
aat
532.
atgagtcataagatattagtatcagacccaatttctgaggatggtttacaaagtatttta
aaacatccagaatttgacgtagatatacaaacagatttatctgaaaatgatttagtaaat
atgatttcaacttatgatgctcttatcgtacgaagtcaaacccaagtaacagagcgaatt
attaatgctgcaacaaatttgaaggtcattgcaagagctggtgtaggtgtggataatatt
aatatagaagcagcgactttaaaaggtattttagtaattaatgctcctgatggtaataca
atttctgctacagaacattcagtagctatgttgcttgcaatggcacgaaatattcctcaa
gcacaccaatctttacgtaacaaagaatggaatcgtaaagcatttagaggggttgaactt
tatggcaaaaccttaggtgttatcggtgctggtaggattggtttgggcgtcgctaaacgt
gcgcagagtttcggtatgaaaattttagcgttcgatccttatttaacagaagataaagcg
aagtcattagatattcaaattgcaactgttgatgaaattgccgaaaaatccgactttgta
acagttcacacaccattaacacctaaaactcgaggaattgttggttcatctttctttaac
aaagctaaacaaaacttacaaatcataaatgttgccagagggggtattatagatgaaact
gcacttattgaagcattagataataacttaatagatcgtgcagctattgacgtatttgaa
catgaacctcctactgattcccctctcattcaacatgataaaattattgtcacaccacat
cttggcgcctctactgtagaagcgcaagagaaggttgcagtctctgtatctgaagaaata
attgaaattctaactaaagggaatgttgagcatgctgtgaatgctccaaaaatggattta
agcaaagttgataaaacaactcaaagctttataggtttaagtacaactattggtgagttt
gctattcagcttctcgatggtgctccgagtgaaattaaagttaaatatgctggtgactta
gcgcaaaatgacactagtttaattacaagaacaattataacgaacatcttgaaagaagat
ttaggtaatgaagtcaatattattaatgcattagcaatacttaaccaacaaggtgtcacg
tataatatagaaaaacaaaagaaacattctggctttagtagttacattgagctagaacta
gttaatgatcaagataaaatcaaaattggcgcaacggtattcgcaggttttggcccaaga
atagtacgtattaatgattactcacttgattttaaacctaaccaatatcaattagtaaca
tgtcataaagataaacctggtatagtaggacaaacaggcaacctattgggaagtcacgga
attaatattgcgtcaatgactttaggacgtaacgatgctggtggagatgctttaatgatt
ctttctattgatcaacaagcaagtgaggaagttataaaaattttaaatgaaacaagcgga
ttcaacaaaattattagcactaagttaacaatt
533.
ttgaagcggaattttattaataatttaatcatattattaattgctattatgttaagtctg
ttattaaaaatgttacatgtgattttgccatttatgtttggaccaatattagcggcgtta
ttatgtgtaaaagtattaaaattaaaaatacgatggccattttggttgagtcaaattggt
ttaatactacttggagttcaaattggctctaccttcacacaacaagtgattaaagacata
agtaaaaattggctaactatcgtttttgtcactatcctactaattttattagctttgata
attgcattcttttttaagaaaattgcacaagtaaatttagaaactgcaattttaagtgtt
ataccaggtgcgctaagccaaatgttagtgatggcagaagaaaataagaaagcaaatata
ttagttgtgagtttaacacagacatcacgtgtaatatttgttgttattttagtaccactt
atttcgtatttttttcaggataaccatcatgaaatgaatcatactacaatggaagtaccc
acactttctcagactttaaatatatggcaaataatcatcttattctcaatggtgggaatc
atctatataggaatgtcaaaaattaacttccccactaaacaattattagcacctataata
gttttaattatatggaatatgacaacacatttaacattttcactagatcattggttgtta
gccacagcgcaacttatttatatgatacgtattggattacagattgccaacttaatgagt
gatttaaagggaagaattgcaatagcaatagcctttcaaaatataatgctcatagtcaca
acgtttataatgataataggaatacatttgattactaatgaatccatcaatgaattgttt
ttaggagcagcaccaggaggtatgagtcaaatagttttagtggctatggctactggagct
gatgtagcgatgatttcaagctatcacatttttagaatattttttatattatttgtcatt
gcgccactaattggttattttattaatgttaaattaaataataaa
534.
gtgaagaaaacgagtagaataattgcattcatactcctcatagctctactattcacagga
atgggtatgacgtataagaatgtagttaaaaatgttaatttaggtctagatttgcaaggt
ggttttgaagtcctcttccaagtagatcctttaaataaaggagataaaattgataaaaaa
gcacttcaagctacatctcaaacattagaaaatcgtgtaaatgttctaggtgtatcagaa
ccgaaaatacaaatcgaagatccaaatcgaattcgtgtacaattagcaggtatcaaggat
caagcacaagcgcgtaaattattatcgacacaagctaatttaacaattagagatgctgaa
gatcatgttttaatgtctggttcagacattaaacaaggctctgctaaacaagaatttaaa
caagaaactaatcaaccaacagttacatttaaagtaaaaagtaaagataaatttaagaaa
gtaactgaaaagatttctaaaaaacgtgacaatgtcatggtagtttggttagatttcgaa
aaaggcgatagttacaagaaagaagctaaaaagcaacaagaaggtaaaaagcctaaattt
atatctgcagcgagtgtagaccaacctattaattctagtagtgttgaaatttcaggtggc
ttcaatgggaaaaaaggtgttgaagaagcgaaacaaatagctgagttattaaatgccggc
tcattaccagttgatttaaaagaaatttactctaactctgttggtgcacaatttggtcaa
gatgctcttgataagaccatgtttgcatcaattgtaggtatagcattaatttatttattt
atgcttggtttctatcgtttgcctggtttagttgcaatcattgccttaaccacttatatt
tatttaactttagtcgcattcaatttcatatcaggtgtattaactctacctggattggcg
gcattagttttaggtgtaggtatggctgtcgatgccaatatcataatgtatgaacgtatt
aaagatgaactaagaattggacgcacgcttaaacaagcgtattcaaaagcaaataaaagt
tcattcttaactatatttgattccaacttaacaactgtcatcgctgcagctgtgcttttc
ttctttggagaaagttcagtcaaaggcttcgcaaccatgttactcttaggtattttaatg
atatttgtaaccgcagtattcttatcaagagggttgttatcattactggtatcttcaaac
ttctttaaaaaacaatactggttatttggtgttaagaagaaggatagacatgatattaat
gaaggtaaagatgtacatgatttaaaaacatcatatgaaaggttaaactttgttaaatta
gctaagccacttatttcacttagtattttaattgtaattattggtttgattatcatttca
atatttaaattaaacttaggtattgatttctcatccggaacaagagcagatattcaatct
aaaaatgctataacacaagcacaggttgagaaaactgtaaaatcagttggattggaacca
gatcaaatacagattaatggtagtggaaataaaaatgccacagttcagtttaaaaaagat
ttatcacgtgaggaagacaataaattaagtgctaaggtgaaatctgaatttggagataat
ccacaaattaataccgtttcacctctcataggccaagagctagctaaaaatgctgtaact
gcattaatacttgcttctataggcattattatctatgtttcactaagatttgaatggcgt
atgggtctatcttctgtacttgcattattacatgacgtatttatcatcattgcaatcttt
agtttgtttagattagaagtagatttaacatttattgcagcagtattaactatcgttggt
tattcaatcaatgatacaatcgtaactttcgaccgtgttcgagaaaatctgcataaagtt
aaagtaattacgcatactgatcaaattgatgatatagtcaaccgctctattagacaaact
atgacacgttctattaatacagtgttgactgtagttgtagttgtagttgcaatattaata
ttaggtgcaccaacaatatttaatttctctttagcattactaattggattattatctggt
gtattctcgtcaattttcattgctgtaccattatggggcatgcttaagaaacgacagttt
aaaaagacaaaaaataataaattagtagtacacaaagagaagaaatctaacgatgaaaaa
atcttagtt
535.
atgggggaaaatacaaaacaagatttcaatcaaaaaggacaaaattttaaattcacaaaa
aaacatagacgattattatatggttcagtttttttaatggctacatcagctattggtcca
gcatttctgactcaaactgcagtgtttactgcacaattttatgctagttttgcatttgca
atattaatttctattattatagatataggcgctcaaataaatatttggagaatattagtg
gtaactggattacgtggacaagaaatatctaataaagtattacctggacttggtactatt
atctccatactaattgcatttggtggtctcgcatttaacataggtaatattgctggtgca
ggtttaggtttaaatgcaatgtttggtcttgatgtaaaatggggtgctgcaataacagct
atttttgcgatacttatctttgttagtagaagtggtcagaaaataatggatgttattagt
atgattctaggtatcgtaatgattttagtagtcgcttatgtcatggttgtttcaaatccc
ccttatggagatgcattagtacatacatttgcacctgaacatcctttcaaacttatatta
cctataattacattagttggtggtacagtagggggttatattacttttgcaggtgcacat
agaattctagattctggtataaaaggtaagtcataccttcctttcgtaaatcgatctgct
gtagcaggtattttaacaactggtgtcatgcgcaccttattgtttttagctgtactaggt
gttgttgtaactggcgttacgcttagttcagaaaatccaccagcatcagttttccaacat
gcattaggtcctataggtaaaaatatttttggcgtagtaatatttgcagcagcaatgtcc
tcagtaattggttctgcatatacaagcgcaacatttttaaaaacactacacaaatcgtta
ctcaataaaaataatcttatcgttattacatttattgtaatttcaacttttgttttctta
tttattggtaaaccggtgagtttacttataatagctggtgcgattaatggttggattcta
ccaatcacattaggtgcaattctcattgcaagtaggaaaaaatctatcgttggtaattac
caacacccaacatggatgcttgtttttggtattatagccgtaattgtcacaataatgact
ggtatcttttcattacaagatttagcaagtctttggaaaggt
536.
gtgtctaataataattttaaagatgatttcgaaaagaatcgtcaatctattaatccagac
gaacatcaaacagaattaaaagaagatgataaaacaaatgaaaataaaaaagaagctgac
tctcaaaacagtttatctaataactcaaatcaacaatttcctccgagaaatgcccaacga
cgaaaaagacgcagagagacagcaactaatcaaagcaaacaacaagacgacaaacatcaa
aaaaatagtgacgctaaaactacagaaggttcattagatgaccgttatgacgaagcacag
ttacagcaacaacatgataaatcgcaacaacaaaataaaactgaaaaacaatcacaagat
aatagaatgaaagatggaaaagatgcagctattgtaaatggaacatctgagtcaccagaa
cataaatcaaaatcaacacaaaatagacccggccctaaagctcaacaacaaaagcgtaaa
tcagaaagtacgcaatcaaaaccgtcaacaaacaaagataaaaaagcagctacaggtgct
ggaatagctggtgcagctggtgttgctggtgcagcagaaacatccaaacgtcatcataat
aaaaaagataaacaagattctaaacactcaaaccatgagaatgacgaaaaatctgttaaa
aatgatgaccaaaagcaatctaaaaaaggcaaaaaagcagcagtcggtgctggcgcagct
gcaggagttggtgcggctggtgttgcgcatcataataatcaaaataaacatcataatgag
gaaaaaaattctaatcaaaacaatcagtacaatgaccaatcagaaggtaagaaaaaaggt
ggtttcatgaaaatcttgttaccacttatagcagccattcttattctaggtgcaatagca
atattcggtggtatggctctaaataatcacaacgatagtaaaagtgatgaccaaaaaata
gcgaatcaaagtaagaaagactcagataaaaaagatggtgcgcaatccgaagataacaaa
gacaaaaaatctgatagtaacaaagacaaaaaatctgattctgataagaacgcagatgat
gactctgataatagttcctcaaatcctaacgctacttcaactaataataacgataatgta
gccaataataactcaaattatacaaaccaaaatcaacaagataatgcaaaccaaaatagc
aataatcaacaggcaactcaaggtcaacaatcacatacagtatacggtcaagaaaactta
tatcgtatcgccatacaatattatggagaaggaactcaagctaacgtagataaaattaaa
cgtgcgaatggattaagcagtaataatattcataatggtcaaacattagttattcctcaa
537.
atggctaaaggggaccaatatcaagctcatactgaaaaatatcatgataaaaagtctaaa
aaaagttataaacctgtgtggattatcattagttttattattttaattacaatcttgtta
ttacccacaccagcaggattacctgtaatggctaaagcagcactagctattttagctttc
gctgtagttatgtgggttacagaagcagttacttatccagtttctgcaacattaatttta
ggattaatgatacttttactaggtttaagtccagttcaagatttatccgaaaaacttgga
aaccctaaaagtggcgacataatactaaaaggtagcgatattttaggaacgaataacgcg
cttagtcacgcttttagtggtttttcaacctcagccgtagcacttgtagctgcagcatta
tttttagcagtagctatgcaggaaaccaatttacataaacgacttgcattacttgtgcta
tcaattgttggaaataaaactagaaatatagtcattggtgctattttagtatctattgtt
ctagcattctttgtaccatcagctacagcacgtgctggtgcagttgtcccaatattactg
ggaatgattgctgcatttaatgtgagtaaggatagtagacttgcttcattattaattatt
actgctgtacaagcagtttcgatatggaatataggtattaaaacggctgcagcacaaaat
attgtagccatcaattttattaaccaaaatttaggacatgatgtatcatggggagagtgg
tttttatatgctgcgccgtggtcaatcattatgtctatagctctttattttataatgatt
aagtttatgccacctgaacatgatgcaattgaaggtggaaaagagttaattaaaaaggaa
cttaataaattaggaccagtcagtcatagagaatggcgactaattgtgatttcagtgctt
ttattattcttctggtcgactgagaaagtattgcatccgattgattcagcttcgattaca
ctagttgctctaggtattatactaatgccaaagattggtgttattacttggaaaggtgtt
gaaaagaagattccttgggggacgattatagtatttggtgtaggaatctcacttggtaat
gtattacttaaaacaggagccgctcaatggttaagtgatcaaacatttggtttgatgggt
cttaaacatttaccgatcatagcaactattgcgttaattaccttatttaatatattaata
catttaggttttgcaagtgcaacgagcttagcctctgcgttaatacctgtgtttatttct
ttgacttcaacgctaaatttaggtgatcatgctattggttttgtattaatacaacaattt
gtgattagttttggtttcctactacctgtcagtgcaccacaaaatatgcttgcatatggt
actgggacttttaccgtaaaggattttttaaagacaggtatacctttaacgatagtaggt
tatattttagttatcgtatttagtttgacgtattggaaatggcttggtttagtg
538.
atgttagatttcattaaccatttgcttagttatcaatttttaaatcgtgcattaatcaca
tctattttagttgggattgtatgtggaacgatgggtagcattattgttttacgtggtctt
tctttaatgggtgatgccatgagtcatgctgttttaccaggtgttgctttatctttctta
tttaatattccaatgtttatcggggcacttgtaacgggaatgcttgcaagtttgtttatt
ggttttattacttcaaacagtaaaacaaaaccagatgctgcaataggaataagtttcact
gcattcctagcatctggcgtcataattattagtttaatcaatagtacaacagatttatat
cacattttatttggcaatttattagcaattacacatcaatcattttggacaacaattgtc
attactgtactggttattttacttattattatcttttatagacctttaatgatttcaaca
tttgatgcaacttttagtcgtatgagcgggctgaacacaacattaattcactactttgtc
atgttattactcgcacttgtaactgttgcgagcatacaaacagttggaattatccttgta
gttgctttactaatcactccagcttctacagcttttttaatcagtaaacaactttatgcc
atgatggtaattgcaagcataatcagcgtgataagttcgattatcggtctatattttagt
tatatatataatattccaagtggagcaactattgtaatctgtacctttatgatttatatt
gtaacgctatcaattactagaattaaaaataaacaaaaaaggagcgctttaacg
539.
ttggcaaagctattatacaaactaggaaaatttatagctaagaacaaatggctaagtgtt
ataggatggcttgttatactaggtgttattatcacgccattaatgataaactcaccgaag
tttgacagtgacatcactatgaacggccttaagtcattagacacaaacgataaaatcagt
aaagaatttcatcaggacagtgagaaagcctcgatgaaaatagtcttccattctaataag
aatgatggactcaataataaagatacgaagaaagatattgaagatgctttagacaatatc
agacaaaatgatgattatatccaaaatatctctaatccatatgacagtggacaagttaat
gatgaaggcgatactgctatcgctaacgtaagttatgtagttccacaaactggattaaaa
gattcttctaaacatatcatcgacaaagaattaaaagatgtaactgacaaccataatgtg
caaattgaaaaaactcaaggtggcgctatgaattccgaacctggtggtacatcagaaatt
gtcggtatcatcgtagcattcgtaatcttacttattacctttggttcacttatcgcagct
ggtatgccaattattagtgcaatcatcggtttaggttcaagtgttggtatcatcgcatta
ttaacatatatctttgatattccaaacttcactcttacactagctgtaatgataggttta
gctgttggtattgactactcactctttattctatttagatttaaagaacttaagaaaaaa
ggtgtcgatactgtagaagctattgcaacagcagtgggtacagcaggcagtgctgtaata
ttcgctggtcttacagttatgattgctgtttgtggtttatcacttgtaggaatcgacttc
ttagcggttatgggattcgcttcagcgattagtgtgttatttgcagtattagcagcatta
acactattacctgccctaatcagtatcttccataaaagtattaaaattaaagataaacca
actaaaagtaaagaccctaaagatcattcttgggcaaaatttattgttggtaagccagtt
atcgctgttattgtaagtttaattattttaattttagctgctataccagtcagtggcatg
cgtttaggtattccagatgatagtttaaaaccaactgactcatcagaatacaaagcctat
aaattaatctcagataattttggcgaaggttataacggacaaattgtcatgttagtaaat
acaaaagatggtggaagtaaaagcactatcgaacgtgatttaaataatatgcgtagtgat
ttagaagacattgataatgttgatacagtttcaaaagcacaactaactgacaacaacaat
tacgcattattcacaatcattcctgaaaaaggaccgaactcacagtcaacagaaaatcta
gtatatgatttacgtgattatcatagccaagcgcaagaaaaatatgactatggcactgaa
atttcaggacaaagtgttattaacatcgatatgtcagaaaaactaaacaacgctattcca
gtatttgcaggcgttattgttgtattagcattcttcttattaatgattgtgttccgttcg
atcttagttccattaaaagcagtactaggctttatcctttcattaatggctacattaggt
ttcacaacattagtcattcaacatggctttatgggtagcttatttggtattgaaaacaca
ggaccattacttgcattccttccagtaatcacaattggattgttattcggacttgccatc
gactacgagctcttcttaatgacacgtgtacatgaagaatacagtaagactggcgataat
gatcattcaatccgtgtaggtatcaaagaaagtggacctgttatcgtagctgctgcactt
attatgttcagtgtattcatcgcattcgtcttccaagatgacagtgcaattaagtcaatg
ggtatcgcattaggtttcggtgtgttattcgacgcattcgtcgtacgtatgacattaatt
ccagcattgacgaaactctttggtaaagcttcatggtaccttcctaaatggttaggtgca
gtattgccaaacgttgacgttgaaggtaaagctttagaagaagataatcatcacgacaca
tcttctgaaaaaggtcatgtcaacgataaaaatagtgaatactctagacaagacaaagat
aactatgtttatcaaaatgacaaacgtaactacaatcgcaattataatgacgaagattat
aaccgttctgtgcatttaaataatcatcatgaccagcatcatcgccaacatcaatatgat
aatcaacgtgatgatatcgactatgaatcactttatactcaagatggcgaccatactcat
catgatgaacgtaattataatgatcgacactatcaagacaattacgatagaaatgatgat
tatcgtcacaacaatcatgatcatcaaaatgataaccatgattatcatgattcaaatttt
gataaaacaacaaacttatacaaagaattaactgatagcaatattgatcaagatgtatta
ttcaaagcattaatgttatacgctcgtgaaaacaacaaaggtgtttacgatagatataac
cgatcatctcaacatcgtcatgatgacgaacttagagac
540.
atgaataaaaaagtagaacatatcggtaaccaatatacgtcacaagaaaataagaaaaaa
caacgacaaaaaatgaaaatgcgtgttgtacgtagacgtattgctttattcggaggtatt
cttttagcgattatcctcattctacttgtattgcttgtcattcaaagacataataacgat
caagatgcagttgaaaggaaagagaaagaaactgagtttcaaaaacaacaagatgaagaa
attgctttaaaagagaaacttaataatttaaatgataaagactatatcgagaaaatagcg
agagacgattattatttaagtaataaaggtgaagtcatttttagattacctgatgataaa
aaatcctctcagtcaaagacttcaaacgaaaaaggcaat
541.
atgaagatacgtttaacatttattatcttagcaatactatccaccatcggcttagtactt
gttttagcaaaatatccaacaggcccacacacaatcaactataacgaaccttatacagta
ctcatagccattacgacaatagttataatggctttaccagcactcatattaggtatattt
aatcatcttgcatgtagaatcatatcggcgatattacaaataagtgcactgatgatgtgg
gggtttttagtaatcattagcttaattatgggacaaattgtcattatgcttatggcttcc
ttaacgatacttgcattacttgttagttctattgtcacactttcagtgcacccatctact
tcagataaaataaat
542.
atgaataagaaactattgtggagcatcattggtattgtaattattgtcgtattaatcatt
gctgcttttatattaaaacaagttaatggttcaggtagtaaagatagtaatgcttacgat
acatatacagtaagaaaagaaacacctattagtttagaaggcaaagcgtctccagaatct
gtgaaaacttataacaataatcaatctgtgggtaacttcttaagtgtttcagtacaagat
ggtcaaacagttaaacaaggtgaacgtatcatcaattatgatacaaatgggaataaacgc
caacaactattgaacaaagtgaatcaagcacaatctcaagttaatgatgattatcaaaaa
gtaaatcaaagtcctaacaatcatcaattacaagttaaattgactcaagatcaaagtgct
ttaaatgaagctcagcagtcattgtcacaatatgacagacaactcaatgacagcatgaat
gcatcatttgatggtaaaattaacattaaaaatgattcagatgtaggcgaagggcaacct
attttgcaattaatttcttcaaatcctcaaattaacgcaactattacagagtttgatatt
aataaaattaaagaaggcgatgaagtaaatgtcactgtaaatagcacaggtaaaaaagga
aaaggaaaaattcttaaaatagatgaacttcctacaagctatgatacaagtgacgatagt
acagcatcatcggcacaagcaggggcacaaggtgatagtgaagaaggaactgaaatgacg
acatctaatcctacaattaatcagccaacaggtggtaaaagtggcgaaacatcaaaatat
aaagttatcattggtgatttagatatacccgtgagatcaggcttctctatggatgctaaa
atccctcttaaaactaaaaagctaccaaataacgtgttaacaaaagataataacgtattt
gtcgttgataaaaataataaagttcacaaacgtgaaattaaaattgaacgtaataatggt
gaaatcattgtgaaaaaaggattgaaatctggcgataaagtccttaaaagtccaaaaggt
aatttaaatgatggagaaaaagtagaggtgtcatca
543.
atggctgaaactactaaaatatttgaatcacatttggtcaaacaggctctaaaagacagt
gtattgaagctctatcctgtttatatgattaaaaatccgattatgtttgttgtagaagtg
ggcatgctgcttgccttaggattaaccatttatccggatttatttcaccaagaaagtgta
tcacggctatatgtgttcagtatctttatcatattattactgacacttgtctttgcgaac
ttctctgaagcattagctgaaggtcgcggtaaagcacaagccaacgctttacgccaaaca
caaactgaaatgaaggcacgtcgtattaaacaagacggcagttatgaaatgattgacgct
agtgacctgaaaaaaggacatatcgtacgtgtcgcgacaggtgaacaaatcccaaatgac
ggtaaagttattaagggcctcgcaacagtggatgaatctgcgattacaggtgaatctgca
cctgtaatcaaagaaagcggtggagatttcgataatgtaattggaggaacttctgtagct
tcagactggttagaagttgagattacttcagaaccaggtcattcatttttagataaaatg
attggtttggttgaaggggctacaagaaagaaaacacctaatgaaattgcgttatttact
ttattgatgacattaacgattatcttcttggtcgttattttaacgatgtatccattggcg
aaattcctgaatttcaatttatccattgcgatgctgattgctttggctgtgtgtttaatt
ccaacaaccattgggggattattatcggctatagggattgcagggatggatcgtgtgaca
cagtttaatatcttggctaaaagcggacgttctgtagagacttgtggtgatgtgaatgtc
ttgattttagataaaacaggtaccattacctacggcaaccgtatggcagatgcgtttatt
ccggtgaaatcatcaagctttgaacgtttagttaaagcggcctatgaaagttctatcgca
gatgacacaccagagggacgtagtattgtgaaattagcttataaacaacatatcgactta
ccgcaagaggtcggagaatatattccgtttactgctgaaacacgtatgagcggtgtgaaa
tttacgacacgtgaagtatataaaggtgcaccgaatagtatggttaagcgtgtgaaagaa
gcagggggacatattccagttgatttagacgctcttgtcaaaggggtgtctaaaaaaggt
ggcacaccgctggttgtgcttgaagataatgagattttaggtgttatttatttgaaagat
gtcattaaagatggactcgtagaacgtttccgtgaattacgtgagatggggattgaaacg
gtgatgtgtacaggagataacgaattgacagctgcgacaatagcgaaagaagcgggtgtg
gatcgctttgtggcagagtgtaaacctgaagataaaatcaatgtgattagagaagaacaa
gcgaaaggtcatattgttgcgatgacgggtgacggtacgaatgacgcgccagctttagca
gaagctaatgtaggtttggcaatgaactcaggaaccatgagtgccaaagaagcggcgaat
ttaattgatttagattctaatccaaccaaactgatggaagtcgttctaattgggaaacaa
ttattaatgacacgtggctcactcactacatttagtattgcgaatgacattgcgaaatac
tttgcgattttaccagccatgtttatggcggctatgcctgcgatgaatcatttgaatatt
atgcatctgcattcacctgaatcagcagtattatctgcgttaatctttaatgcgttgatt
attgtattattgattccgattgcgatgaaaggcgtgaaatttaaaggtgcctcaacgcaa
accatattgatgaaaaatatgttagtttacggcttaggcggtatgatcgtgccatttatc
ggcattaagctcattgatctcatcatccaactctttgtc
544.
atgattgtgttacgtcgtctatttcaagatagaggtgccatatttgctatagctattatt
acaatctacgtagtgcttggagttttagctcctttaattacattctatgaaccgaatcac
attgatacagcaaataaatttgctggtataagttggtctcactggttgggaacagaccat
ttaggtcgagatgtattaacacggataatatacgccataagacctagtttgttatatgta
tttgtcgcattgattatttccgttgtgataggagcgatacttgggtttatttcaggttat
ttcccaggttatatcgatgcaataattatgcgtatatgcgatgtgatgttagcttttcca
agctatgtggtcacattggcattgattacgttgtttggcatgggtgtagaaaatattatt
attgcatttatattgactcgatgggcgtggttttgtcgcgtgattcgaaccagtgtaatg
caatatattgaagctgatcatgtaaaatttgccaaagtaattggtatgaatgatttaaca
atcattcgcaaacatattttgccactaacctttactgacatagcgattattgctagtagt
tcgatgtgttcaatgatattacaaatgtcaggattctcattccttggattaggtgttaag
gcacctacagccgaatgggggatgatgcttaatgaagcacgaaaagtaatgttcacacat
cctggaatgatgatgacaacaggtgtggctatcgtcataattgtgatggcgtttaacttt
ttatcagatgctttacaaatggcgattgatcctcgtatgtccgctaaagaaaaacgactg
gctctgaagaaaggtgtgaaagcacgtgacactgct
545.
atgaaaggtgccatgtcttggccttttttaagattatatattttaacattgatgtttttt
agtgcgaatgccatactcaatgttttcatacctctaagaggacatgacttgggggcgacg
aatactgtaattggaattgtaatgggagcttatatgctaacggcaatgctatgtcgcccc
tgggctggtcaaattattgcacgtattggtccgattaaagtattgcgtattatattattg
attaatgctatggcactggtattatatgggtttacaggacttgaaggttatttgattgca
cgtatcatgcaaggtgtgtgtacggcattcttctcaatgtctttacaattgggtattata
gatgctttacctgagaaatatcgttcagaaggtgtatctctctattcattattttcaacg
attcccaatttattaggaccattaattgcagttgggatttggcacgtggaaaatatgtcc
atatttgctattgttatgatttttattgcagtaacaacaaccttatttggttatagaact
acttttgcaaatacacaaaaagaggtatcaccaaaagacgaagtcttgccttttaatgca
atgactgtatatgtccaattttttaaaaataaagcactcttctgcagtggtatgattatg
atcttgtcatctatcgtgtttggtgcgatgagtacttttataccattatatacggttagg
gaaggtttcgcgaatgcaggtattttcctcacaattcaagccattacagtagtgatagct
agattttatttacgtaagtatgtaccatctgatggtttatggcatcaccgttttatgatg
attgtcttaacgttactgatggttgcttcagtcattgtagcttttggaccacatatagtg
agtatatttgtatatataagtgcaatctttatcggaataacacaagcgctcgtttatcct
acattgacaacgtatttaagttttgtcttaccaaagataggacgtaatatgttattagga
ttgtttatagcatgtgcagatttagggatttcactaggaggtgtgctaatggggccaata
tcagatacggtaggatttaaatggatgtatattttatgcgctttattggttactattgca
atgacactaagtaaaattagacaaagacaaagtgtttcaaaagcctca
546.
gtgggaagtactgttaaatatcgtaagtttattctacctattgtcgttggtttaattatc
tgggcattgacgcctattaaaccagatgccttaaatgatcaagcttggtttatgtttgct
atttttgtgtcaaccatcattgcttgtattacccaacctatgactataggtgcagtatca
atcattggttttacaatcatgattttggttggaattgttgatacaaaaactgccgttcaa
ggcttcggtaatagtagtatttggcttattgcaatggcctttttcatttcaagaggattt
gtaaaaacagggctaggtcgacgtattgctctgcaattcgttaaattatttggaaagaaa
acgcttggtttggcttattcacttgttggtgttgatcttatcttagctcctgctacgcca
agtaatacagcacgtgctggtggtattatgtttccaatcattaagtccttgtcagagtca
tttggttcatcgccgagagatggttctgagagaaaaatgggtgcgtttttaatctttact
gagttccaaggtaatttaattacttcagctatgtttttaacagctatggccggtaaccct
atagcgcaaagtttagctgaaaaaacggcacacgttcaaattacatggatgaattggttt
gttgctgctattatacccggattgatttctctcatcgttgtccctttcattatttataaa
ttatacccaccaactgttaaagaaacgcctaacgctaaaaaatgggctactgaacaacta
gaagaaatgggacatatgtctatagccgaaaaattgatggttggtatctttatcatagca
ttggctttgtgggtattaggaagcttcattaatgttgatgccacgctcactgcatttatt
gctttagcattgttactattaacaggtgtattagcgtggtcagatattttaaatgaaaca
ggcgcatggaatacactcgtttggttctcagttcttgtattaatggcagaacaattaaac
aagttaggctttatcccatggttaagcaaactcattgctcaaggtttaaatggctttagt
tggcctatcgttttagttttactcatcttgttttatttctactcacattatttattcgca
agtgcaacagcacatgtcagcgccatgtacgccgcgttactcggtgttgcagtcgcttcg
ggtgcaccgccattattcagtgcattaatgttagggttctttggtaacttactggcatca
acaacacactatagtagtggaccagcgcccatattatacgcagctggctatgttacacaa
aagcgctggtggactatgaatattgtacttggtatagtctattttattatttggattggt
gtaggttcactatggatgaaactcataggtatgatg
547.
atgaaagataataaaatgttgttcattatttttatgataggaacatttacagtaggaatg
gctgaatatgtagtgacaggattacttacacaaatcgctgacgatatgaaggtttctatt
tcgagtgcaggtttattaattagtgtttatgctattagtgttgcattgatagggccttta
atgcgaatcataacattgaaagttcacgcccaccgtctgttaccgattttagtagcgatt
tttataataagtaatttagtgggaatgttagcaccgaattttaatgtattgttattatca
agactcatgtctgcggcaatgcatgcgccattcttcggtgtgtgtatgagtgttgctgcg
acagtcgcacctcctgctaaaaaaacacaggccattgcacttgttcaggcaggtttaact
attgctgtaatgttaggtgtaccattcggatcatttttaggtggctttgcaaattggaga
gttgtttttggatttatgattgtgttggcaatcattactatgttaggaatgattaaattt
gttccaaatgtttctttaagtgcagaagcaaatattagcaaagaattaacagtgtttaag
aatccacacattttaattgtgattgcaattattgtgtttggttactctggtgtgtttact
acttatacatttatggagccaatgatacgagatttttctccatttaaaattgtaggttta
actgtttgtttatttatgtttggtctaggcggtgtgatagggaatttaattactggtaat
gtaccggaagataaattaacaaaaaatttataccttacatttcttttactatttgtaaca
atcatactatttgttactgttattcaaaattcaatattagcattaatcatttgcttctta
ttcggttttggtacatttggtacaaccccgttacttaatagcaaaattatcttaagtgga
aaagaagcaccacttcttgcaagtacgttagcagcttctattttcaatgttgctaatttt
cttggtgcaataattggatctatattattatcaatagggttaccttacattcaaattact
ttgatatctggtggaattatagtgttgggtatgcttcttaatcttgttaatcaactttat
gaaaagaaacatatcacatttaatgaatattca
548.
qvlkmlqnilllmllllmlkikvliylimtllnqfrdmvlklrfinnkslwaien
549.
krlvmqqhlqfnlpkiillnaltkrflsllvtqlvmvfilvvsllkvpvqlq
550.
lrlrqfqllctlvllmlvalflhaflrylmtk
551.
rlrytsyiiklaatdafklltcptigili
552.
ssvfairltitfsrfsnvgckkhikgaiimkkeiiewivaiivaivivtlvqkflfasyt
vkgasnviyh
553.
rsvphivvltmriiasvllvivgfslsvsca
554.
tanniisfiitltniyktklmgyffniielrnkfirrcwailfiaiihfisecflphipt
ncyvsrfdfldsaknmsyktlnticrnsfrivhkliv
555.
ffcrltqlnwlkylsvrmlymyfmifsimnhivstic
556.
ifistcgcsttsawkaevlplrvrfpspapf
557.
lknilrivfiagltvffsgpgqtysnaafideyiqtfgwsrtev
558.
rnsnqmyqtftadivlifmiivlgglvvqvpmpilagimvmvsetiyclhl
559.
nqrleetissphhssal
560.
mkqflnitqrkfiewliilsifivsipnkwtlmisialsllllkrgalgvvqliilymlr
sqiytpydtqemahyivsmkyiliyvigvfflfkyvkhwirnemilrfikstmilmllyi
imslvvsndpiesilkllnffiplilivmyvslikkiknlinwinqfitlviaftflfiv
iapksylideeslrsvfkdahsfavilamglvlymvtiikqqdydvfnllllnigmiely
lsnsrhifisvilclmlllplshikkrikhpiigamilmaiaiinqpyiyhlfiklilkg
knsqevfmpsdmnikaidyaltehpflgsgfgipmikasseiqyfnvatsniifgmiift
giigltlctiymlhmvllvtfpmsitillflitifvnmdyiilfdsvglgilcyifwgiy
lkegmyqynngqw
561.
mtnqktvglvvapgvterlaenliqempkmlsthydhqqewifdlvtdpltgfaesvdei
fgkvadyhdkrqwdyviaitdlpmfadkqvmaldinmengaaifsypafgwrpvkkrfkh
aiyniiqelneaeqesrnydnnkqiensvkkqfplskidketiymketdsyhlrylsssr
srgmfrlvsgmtfannplnmmaslsnivaiafttgafglvfttmwqmaynfsmwrlfgis
iiaiigmliwimmshdlwepvnksnhkhitwlynlttimtlifaiiiyyiilyllfliae
ivllpsgflgqqvglkgpagidlylsipwfaasistvagaigagllndelikestygyrq
rvryeeqrr
562.
mkfcphcgnpikkeqsfcnkcgkhlktstqrksenqiehmreqqsyisreerqhhdstfy
keqkhtgwlivlsiifvlliaallygayyaynhyisdeqshqttesqqsnesdqnrdqst
gpsidvfsddfdqgymksastsgyrgvyngmtreevedkfgtsngsveslkwsyetygdl
avayddnevvsvgvapnhisedqflsmynepddrnssqliydsnkdndfsvlanvkngdv
tvienvnqi
563.
mllfiieiiimilaillglrtagalgcgifaivaqlimifgfqlppgsapvtavliilsi
giaggtlqatggidylvyiasrvierfpksiifiapmivfvfvfgigtanialslepiia
ktaqkariqpkraltasvltanlallcspaasatayiisvlagyeismgkylsivlptal
ismlmlstfctfvgrkehvrdeserlvqmpeveikndfslkvkigvisfllcvmgiltfg
ifpnlmpqfnvngdvvkvemteivqffmylsatinlllikintsdilssnitqsamgalf
avlgpgwlgatifnaphnlkilkndigsiisevpwlviilvsvvamivisqtatasimvp
ivmslgippiyfvamvqtlnvnfvipaqptllfaveldetgrtrptsfmipgffvitvsv
itgfviktilgy
564.
mgsffnrmtrkenptiyqnkdghlkrtlrvrdflalgvgtivstsiftlpgvvaaehagp
avalsfllaaivaglvaftyaemastmpfagsayswinvlfgelfgwvagwallaeyfia
vafvasgfsanlrgliaplgislpkslsnpfgsnggvidiiaavviiltalllsrgmnea
armenvlvilkvlaiilfvivgltainfsnyipfipehkvtetgdfggwqgiyagvsmif
layigfdsiaansaeainpqktmprgilgslivaivlfvavalvlvgmfhysqyadnaep
vgwalresghgiiaaivqaisvigmftaligmmlagsrllysfgrdgllpswlsqlnhkh
lpnralviltiigvvigsmfpfaflaqlisagtlvafmfvslamyrlrkregkdlpkpef
klplypilpaitfilvllvfwglsfeaklytliwfivgiiiyliygirhskkndeeayqv
pre
565.
mtkkkrlspsewllkqskrhkrkntlytaivllvalvllifavksiqvepvksdtrdkds
iritylgnvtlnkhirqtnlndvfkgiqdtldhsdfstgslivndfsrnqkdninknien
imflrkhnvksvnlinesmdniqatammrkidsqagynfltgngsnpinsktvqqdikgk
kianvsftdiesnytnslknttsisldpaifyplikklkenndyvvvnvdwgipnernvt
trqkeyahalanagadviighntviqkvenykrtpifyslgnttsdnflsknqkgmivqq
dwkgshnqfhitpiqskdgkiskdnmnkmdhirfknnikdksidlksdqnggytfey
566.
miehlgintpyfgilvslipfviatyfykktngffllaplfvsmvagiaflkltgisyen
ykiggdiinfflepaticfaiplyrkrevlkkywlqifggiavgtiiallliylvaitfq
fgnqiiasmlpqaattaialpvsdgiggvkeltslavilnavvisalgakivklfkisnp
iarglalgtsghtlgvaaakelgeteesmgsiavvivgvivvavvpilapill
567.
mkrtdkyrdsykyddqyqnhrkrseedmyrqhqesqqransnratqsendreyenhpery
yngrdyrreqqleeenekssktkkwliaiivilliivaifitraiinhnndkvsndpnvs
qnykkevenqnddinrqvdsaksdiknkkdtqsqidklqnqidqlkqneetnadskftkf
yqnqidklknannaqlnnenqskvnnmledintkfdsikaklenilngsnsgn
568.
mknkkglgiglitimiivcivlvimmfvggkkesyygimkdsttidkmintknekieknv
elpkdanvsvkkedfvmlfkdektgkitkvkkvnhddvphglmskihdmgnmkhgm
569.
mamsllvslvvymmtltsdiledilsfklevimqfpyilssisliilfilfilkdmekiw
ywlisivmiavismsghvwsqqvplwsiiirtihligltlwlgslvylicyaikvkinql
tsvrrmllkvniiavimlvftgilmaidetntltlwnnvsawsiylvikiagiiammllg
fyqtmralrqrqqvhrfalmtelligmililqvs
570.
mknsrfsgfqwammvfvffvitmalsvilrdfqatigvkrfvfsikdlapfiaaivcilv
fkhrkeqlaglkfsislkvierlllalilpliilmiglfsfntyadsfillqtsdlsvsl
ltilighilmafvvefgfrsylqniletrmntffasivvgliysvftanttygveyagyh
flytfmfsmiigeliratngrtiyiatafhasmtfalvflfseetgdlfsmkvialstti
vgvsfiiisliiraivykttkqsldevdpnnylshiqdeepsqedasstsnhdvsskdet
kqqdidndkhqskkpnksddalttsnykedassvnketdtthndnikdhstytedrhssv
vndvkdeihevedhkadtdksh
571.
mennelqrglnarqmqmialggtigvglfmgatstikwtgpsvilayliagiflflimra
mgemiyinpttgsfatfasdyihpaagymtawsnvfqwvvvgmseviavgeymnywfpsl
pnwipgviavlflmaanlvsvkafgefefwfalikvvtivlmiiaglglilfgignggnp
igisnlwshggfmpngfigfffalsivigsyqgveligisagetknpqtnivkavngviw
rilifyigaifvivsvypwnqlgsigspfvatfakvgitfaaglinfvvltaalsgcnsg
ifsasrmiytlakkgqmpkvftkvmkngvpfytvfavsmgiligallnvilpliidgads
ifvyvysasilpgmipwfmilfshlrfrrlhpekvhnhpfkmpggaianyltimflllvl
vgmllnketvvsvvigivfltavtlyyliryhkkerqi
572.
lqdfdnlipgwfktfvqvgndliwsqyligllltagffftisskfiqlrmlpemfralte
kpetlssgekgispfqafaisagsrvgtgniagvataivlggpgavfwmwiiafigaasa
fmeatlaqvykvhdkeggfrggpayyitkglnqkwlgivfavlitvtfafvfntvqanti
aeslntqynispvitgivlavitgiiifggvrsiatlsslivpimaivyigmvliillln
idqivpmigtiiksafgvqqvtggavgaailqgikrglfsneagmgsapnaaatsavphp
vkqgliqslgvffdtmlvctataimillysglqfgdsapqgvavtqsalnehlgsaggif
ltvavtlfafssvvgnyyygqsnieflsnnkmilfifrcfvvllvfvgavaktetvwsta
dlfmglmaivniisiiglsniafavmkdyqrqrkegkrpvfkpenleinlfgietwgqha
kmpkk
573.
lkkeilewivaiavaialiaiitkfvgksysikgdsmdptlkdgervvvniigyklggve
kgnvivfhankkddyvkrvigtpgdsveykndtlyvngkkqsepylnynekrkqteyitg
sfktknlpnanpqsnvipkgkylvlgdnrevskdsrsfglidkdqivgkvslrywpfsef
ksnfnpnntkn
574.
mfnkvwfrtgiffimlfiliklfmevhevfapiatiigsvflpflisgflfyiclpfqni
lekwgfprwasittifigliaiiaivvsfiapiiisninnlikqtpslqkeaeqlinfsl
rqmdklpddvthrinkavksmgdgatsilsnsvsyitsfistvfllimvpffliymlkdh
ekfipaigkffkgerkvfvvdllkdlnftlksyiqgqvtvsiilgiilyigytiiglpyt
pllvlfagvanlipflgpwlsfapaailgiidgpstfiwvcvvtliaqqlegnvitpnvm
gkslsihpltiivvilaagdlggftlilvavplyaviktlvsnifkyrqrivdkansnvkd
575.
mntivkhtvgfiasivltllavfvtlytnmtfhakvtiifgfafiqaalqllmfmhlteg
kdgrlqsfkvifaiiitlvtvigtywvmqgghsshl
576.
mlgeqytqikrpanrltekilgwfswvflliltivsmfialvsfsndtsianlentlnnn
elvqqilanndlsttqfviwlqngvwaiivyfivcllisflalismnirilsgllfliaa
ivtiplvllivtliipilffiiammmfarrdrietvpsyyneydqpyydergfyepesrn
ehgynddvyepmhtkkedrntrrqfnrnaqqqdsyngitdnqpdedtssdqlysdeyvdn
edkysqfpkraveseyasqqtedeptvmsrqakynkkskntdfedaqqehmegnqfddvg
vvepqidpkelkaqrkrekaeirakkkekrkaynkrmkerrknqpsavnqrrmnyeerrq
minneqedtdnnlnqqedskken
577.
meenknqpnnenmsnkddntihlndsqsnedlelfrrnknarqrrrrridnqskekdats
tqsqletkpmdkfidnhkshnqdkeiksdliednvndeddnqkynndklndrsvqqtset
rqsnedeeefltdhqsekqtkdsrhskkhkllskftskkeketftsfnsnekvtqikpls
leekrairrkkqkriqytiitlliliivlillymftplskisnvnikgnnnvstskikke
lnvtsrsrmytfsknkairnlkqnplikevdihkqlpntltvnvteyqivgleknkdkyv
piiedgkelteykdevshdgpiidgfkgdkktriikalsemspkvrnliaevsyaptknk
qsrikiftkdnmqvigdittiadkmqyypqmsqslsrddsgelktngyidlsvgasfipy
qgsstvqsgteqnvtkstqeendakeelqnvlnkinkqskenn
578.
mkclfkmlsiiiimlstftlfispstyanedenwtkiknrgelrvglsadyaplefekti
hgkteyagvdielakkiakdnhlklkivnmqfdsllgalktgkidiiisgmtttperkke
vdftkpymitnnvmmikkddakryqnikdfegkkiaaqkgtdqekiaqteiedskissln
rlpeailslksgkvagvvvekpvgeaylkqnseltfskikfneekkqtciavpknspvll
dklnqtidnvkeknlidqymtkaaedmqddgnfiskygsffikgikntilislvgvvlgs
ilgsfiallkiskirplqwiasiyieflrgtpmlvqvfivffgttaalgldisalicgti
alvinssayiaeiiraginavdkgqteaarslglnyrqtmqsvvmpqaikkilpalgnef
vtlikessivstigvseimfnaqvvqgisfdpftpllvaallyflltfaltrvmnfiegr
msasd
579.
mshkilvsdpisedglqsilkhpefdvdiqtdlsendlvnmistydalivrsqtqvteri
inaatnlkviaragvgvdninieaatlkgilvinapdgntisatehsvamllamarnipq
ahqslrnkewnrkafrgvelygktlgvigagriglgvakraqsfgmkilafdpyltedka
ksldiqiatvdeiaeksdfvtvhtpltpktrgivgssffnkakqnlqiinvarggiidet
aliealdnnlidraaidvfehepptdspliqhdkiivtphlgastveaqekvavsvseei
ieiltkgnvehavnapkmdlskvdkttqsfiglsttigefaiqlldgapseikvkyagdl
aqndtslitrtiitnilkedlgnevniinalailnqqgvtyniekqkkhsgfssyielel
vndqdkikigatvfagfgprivrindysldfkpnqyqlvtchkdkpgivgqtgnllgshg
iniasmtlgrndaggdalmilsidqqaseevikilnetsgfnkiistklti
580.
lkrnfinnliilliaimlslllkmlhvilpfmfgpilaallcvkvlklkirwpfwlsqig
lillgvqigstftqqvikdisknwltivfvtillillaliiafffkkiaqvnletailsv
ipgalsqmlvmaeenkkanilvvsltqtsrvifvvilvplisyffqdnhhemnhttmevp
tlsqtlniwqiiilfsmvgiiyigmskinfptkqllapiivliiwnmtthltfsldhwll
ataqliymiriglqianlmsdlkgriaiaiafqnimlivttfimiigihlitnesinelf
lgaapggmsqivlvamatgadvamissyhifriffilfviapligyfinvklnnk
581.
vkktsriiafilliallftgmgmtyknvvknvnlgldlqggfevlfqvdplnkgdkidkk
alqatsqtlenrvnvlgvsepkiqiedpnrirvqlagikdqaqarkllstqanltirdae
dhvlmsgsdikqgsakqefkqetnqptvtfkvkskdkfkkvtekiskkrdnvmvvwldfe
kgdsykkeakkqqegkkpkfisaasvdqpinsssveisggfngkkgveeakqiaellnag
slpvdlkeiysnsvgaqfgqdaldktmfasivgialiylfmlgfyrlpglvaiialttyi
yltlvafnfisgvltlpglaalvlgvgmavdaniimyerikdelrigrtlkqayskanks
sfltifdsnlttviaaavlfffgessvkgfatmlllgilmifvtavflsrgllsllvssn
ffkkqywlfgvkkkdrhdinegkdvhdlktsyerlnfvklakplislsiliviigliiis
ifklnlgidfssgtradiqsknaitqaqvektvksvglepdqiqingsgnknatvqfkkd
lsreednklsakvksefgdnpqintvspligqelaknavtalilasigiiiyvslrfewr
mglssvlallhdvfiiiaifslfrlevdltfiaavltivgysindtivtfdrvrenlhkv
kvithtdqiddivnrsirqtmtrsintvltvvvvvvaililgaptifnfslalligllsg
vfssifiavplwgmlkkrqfkktknnklvvhkekksndekilv
582.
mgentkqdfnqkgqnfkftkkhrrllygsvflmatsaigpafltqtavftaqfyasfafa
ilisiiidigaqiniwrilvvtglrgqeisnkvlpglgtiisiliafgglafnigniaga
glglnamfgldvkwgaaitaifailifvsrsgqkimdvismilgivmilvvayvmvvsnp
pygdalvhtfapehpfklilpiitlvggtvggyitfagahrildsgikgksylpfvnrsa
vagilttgvmrtllflavlgvvvtgvtlssenppasvfqhalgpigknifgvvifaaams
svigsaytsatflktlhksllnknnlivitfivistfvflfigkpvslliiagaingwil
pitlgailiasrkksivgnyqhptwmlvfgiiavivtimtgifslqdlaslwkg
583.
vsnnnfkddfeknrqsinpdehqtelkeddktnenkkeadsqnslsnnsnqqfpprnaqr
rkrrretatnqskqqddkhqknsdakttegslddrydeaqlqqqhdksqqqnktekqsqd
nrmkdgkdaaivngtsespehkskstqnrpgpkaqqqkrksestqskpstnkdkkaatga
giagaagvagaaetskrhhnkkdkqdskhsnhendeksvknddqkqskkgkkaavgagaa
agvgaagvahhnnqnkhhneeknsnqnnqyndqsegkkkggfmkillpliaaililgaia
ifggmalnnhndsksddqkianqskkdsdkkdgaqsednkdkksdsnkdkksdsdknadd
dsdnsssnpnatstnnndnvannnsnytnqnqqdnanqnsnnqqatqgqqshtvygqenl
yriaiqyygegtqanvdkikranglssnnihngqtlvipq
584.
makgdqyqahtekyhdkkskksykpvwiiisfiilitilllptpaglpvmakaalailaf
avvmwvteavtypvsatlilglmilllglspvqdlseklgnpksgdiilkgsdilgtnna
lshafsgfstsavalvaaalflavamqetnlhkrlallvlsivgnktrnivigailvsiv
laffvpsataragavvpillgmiaafnvskdsrlaslliitavqavsiwnigiktaaaqn
ivainfinqnlghdvswgewflyaapwsiimsialyfimikfmppehdaieggkelikke
lnklgpvshrewrlivisvlllffwstekvlhpidsasitlvalgiilmpkigvitwkgv
ekkipwgtiivfgvgislgnvllktgaaqwlsdqtfglmglkhlpiiatialitlfnili
hlgfasatslasalipvfisltstlnlgdhaigfvliqqfvisfgfllpvsapqnmlayg
tgtftvkdflktgipltivgyilvivfsltywkwlglv
585.
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fnipmfigalvtgmlaslfigfitsnsktkpdaaigisftaflasgviiislinsttdly
hilfgnllaithqsfwttivitvlvilliiifyrplmistfdatfsrmsglnttlihyfv
mlllalvtvasiqtvgiilvvallitpastafliskqlyammviasiisvissiiglyfs
yiynipsgativictfmiyivtlsitriknkqkrsalt
586.
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kefhqdsekasmkivfhsnkndglnnkdtkkdiedaldnirqnddyiqnisnpydsgqvn
degdtaianvsyvvpqtglkdsskhiidkelkdvtdnhnvqiektqggamnsepggtsei
vgiivafvillitfgsliaagmpiisaiiglgssvgiialltyifdipnftltlavmigl
avgidyslfilfrfkelkkkgvdtveaiatavgtagsavifagltvmiavcglslvgidf
lavmgfasaisvlfavlaaltllpalisifhksikikdkptkskdpkdhswakfivgkpv
iavivsliililaaipvsgmrlgipddslkptdsseykayklisdnfgegyngqivmlvn
tkdggskstierdlnnmrsdledidnvdtvskaqltdnnnyalftiipekgpnsqstenl
vydlrdyhsqaqekydygteisgqsvinidmseklnnaipvfagvivvlaffllmivfrs
ilvplkavlgfilslmatlgfttlviqhgfmgslfgientgpllaflpvitigllfglai
dyelflmtrvheeysktgdndhsirvgikesgpvivaaalimfsvfiafvfqddsaiksm
gialgfgvlfdafvvrmtlipaltklfgkaswylpkwlgavlpnvdvegkaleednhhdt
ssekghvndknseysrqdkdnyvyqndkrnynrnyndedynrsvhlnnhhdqhhrqhqyd
nqrddidyeslytqdgdhthhdernyndrhyqdnydrnddyrhnnhdhqndnhdyhdsnf
dkttnlykeltdsnidqdvlfkalmlyarennkgvydrynrssqhrhddelrd
587.
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qdaverkeketefqkqqdeeialkeklnnlndkdyiekiarddyylsnkgevifrlpddk
kssqsktsnekgn
588.
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nhlacriisailqisalmmwgflviislimgqivimlmasltilallvssivtlsvhpst
sdkin
589.
mnkkllwsiigiviivvliiaafilkqvngsgskdsnaydtytvrketpislegkaspes
vktynnnqsvgnflsvsvqdgqtvkqgeriinydtngnkrqqllnkvnqaqsqvnddyqk
vnqspnnhqlqvkltqdqsalneaqqslsqydrqlndsmnasfdgkinikndsdvgegqp
ilqlissnpqinatitefdinkikegdevnvtvnstgkkgkgkilkidelptsydtsdds
tassaqagaqgdseegtemttsnptinqptggksgetskykviigdldipvrsgfsmdak
iplktkklpnnvltkdnnvfvvdknnkvhkreikiernngeiivkkglksgdkvlkspkg
nlndgekvevss
590.
maettkifeshlvkqalkdsvlklypvymiknpimfvvevgmllalgltiypdlfhqesv
srlyvfsifiillltlvfanfsealaegrgkaqanalrqtqtemkarrikqdgsyemida
sdlkkghivrvatgeqipndgkvikglatvdesaitgesapvikesggdfdnviggtsva
sdwleveitsepghsfldkmiglvegatrkktpneialftllmtltiiflvviltmypla
kflnfnlsiamlialavclipttiggllsaigiagmdrvtqfnilaksgrsvetcgdvnv
lildktgtitygnrmadafipvksssferlvkaayessiaddtpegrsivklaykqhidl
pqevgeyipftaetrmsgvkfttrevykgapnsmvkrvkeagghipvdldalvkgvskkg
gtplvvledneilgviylkdvikdglverfrelremgietvmctgdneltaatiakeagv
drfvaeckpedkinvireeqakghivamtgdgtndapalaeanvglamnsgtmsakeaan
lidldsnptklmevvligkqllmtrgslttfsiandiakyfailpamfmaampamnhlni
mhlhspesavlsalifnaliivllipiamkgvkfkgastqtilmknmlvyglggmivpfi
giklidliiqlfv
591.
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lgrdvltriiyairpsllyvfvaliisvvigailgfisgyfpgyidaiimricdvmlafp
syvvtlalitlfgmgveniiiafiltrwawfcrvirtsvmqyieadhvkfakvigmndlt
iirkhilpltftdiaiiasssmcsmilqmsgfsflglgvkaptaewgmmlnearkvmfth
pgmmmttgvaiviivmafnflsdalqmaidprmsakekrlalkkgvkardta
592.
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wagqiiarigpikvlriillinamalvlygftglegyliarimqgvctaffsmslqlgii
dalpekyrsegvslyslfstipnllgpliavgiwhvenmsifaivmifiavtttlfgyrt
tfantqkevspkdevlpfnamtvyvqffknkalfcsgmimilssivfgamstfiplytvr
egfanagifltiqaitvviarfylrkyvpsdglwhhrfmmivltllmvasvivafgphiv
sifvyisaifigitqalvyptlttylsfvlpkigrnmllglfiacadlgislggvlmgpi
sdtvgfkwmyilcallvtiamtlskirqrqsvskas
593.
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iigftimilvgivdtktavqgfgnssiwliamaffisrgfvktglgrrialqfvklfgkk
tlglayslvgvdlilapatpsntaraggimfpiikslsesfgssprdgserkmgaflift
efqgnlitsamfltamagnpiaqslaektahvqitwmnwfvaaiipglislivvpfiiyk
lypptvketpnakkwateqleemghmsiaeklmvgifiialalwvlgsfinvdatltafi
alalllltgvlawsdilnetgawntlvwfsvlvlmaeqlnklgfipwlskliaqglngfs
wpivlvllilfyfyshylfasatahvsamyaallgvavasgapplfsalmlgffgnllas
tthyssgpapilyaagyvtqkrwwtmnivlgivyfiiwigvgslwmkligmm
594.
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mriitlkvhahrllpilvaifiisnlvgmlapnfnvlllsrlmsaamhapffgvcmsvaa
tvappakktqaialvqagltiavmlgvpfgsflggfanwrvvfgfmivlaiitmlgmikf
vpnvslsaeaniskeltvfknphiliviaiivfgysgvfttytfmepmirdfspfkivgl
tvclfmfglggvignlitgnvpedkltknlyltflllfvtiilfvtviqnsilaliicfl
fgfgtfgttpllnskiilsgkeapllastlaasifnvanflgaiigsillsiglpyiqit
lisggiivlgmllnlvnqlyekkhitfneys
595.
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VDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLIS
APATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAY
TGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATG
SLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVM
SVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK
596.
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lvlsifkpthrkpglyknfddghiyvsrkavektiydtiakydqvrqpnvvsklynkknk
sfidikadffvpnhvqvksltesiradiksnvehfteipvrklevnvrdqktsgprvl
597.
msflrkhteiifsyiigivslftgliifinlplikqfkgdkkvdthvhnvweflnaffae
iikvmskfiggfpitsaiviivfgilvmllghtlfrtikydydisifflvigimyfiitl
llmtqvygffaivfiipftvhigyivykdelnqdnrknhymwiivtygmsylitqislyg
ridaneiesidilsvntffiimwllgqmaiwnflflrrslpltkeelgeeepelsrtnkg
nvsnqtkvhlkqlqnktteyarktrrsvdldkirakrdkfkqkinsivdiqeddipnwmk
kpkwvkpmyvqlfcgviilffaflefnnrnalfltgewelsqtqyvvewvtlllllfiii
iyiattltyylrdkyyylqlfmgsilffkfltefinimvhglllsifitpilllmliami
vayslqlrek
598.
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nlqmivpatsnsnnetkettennvndkdernhktaveetktnydstkentkepgkenesa
trlensalekaksyyddfhmsklgiydiltseygekfdkedaqyaidhleadyeknalek
aksyakdmhmsndsiydllvsnygekfteseakyaiehldn
Claims (13)
- (a) 서열 번호 55, 56, 57, 58, 59, 60, 62, 66, 67, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 87, 88, 89, 90, 92, 94, 95, 96, 97, 99, 100, 101, 102, 103, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 126, 128, 130, 132, 134, 138, 140, 151, 152, 154, 155, 158, 168, 174, 또는 176에 열거된 아미노산 서열을 갖는 폴리펩티드; 또는(b) 서열 번호 55의 아미노산(aa) 12-29, 34-40, 63-71, 101-110, 114-122, 130-138, 140-195, 197-209, 215-229, 239-253, 255-274, 39-94;서열 번호 56의 aa 5-39, 111-117, 125-132, 134-141, 167-191, 196-202, 214-232, 236-241, 244-249, 292-297, 319-328, 336-341, 365-380, 385-391, 407-416, 420-429, 435-441, 452-461, 477-488, 491-498, 518-532, 545-556, 569-576, 581-587, 595-602, 604-609, 617-640, 643-651, 702-715, 723-731, 786-793, 805-811, 826-839, 874-889, 37-49, 63-77, 274-334;서열 번호 57의 aa 28-55, 82-100, 105-111, 125-131, 137-143, 1-49;서열 번호 58의 aa 33-43, 45-51, 57-63, 65-72, 80-96, 99-110, 123-129, 161-171, 173-179, 185-191, 193-200, 208-224, 227-246, 252-258, 294-308, 321-329, 344-352, 691-707, 358-411, 588-606;서열 번호 59의 aa 16-38, 71-77, 87-94, 105-112, 124-144, 158-164, 169-177, 180-186, 194-204, 221-228, 236-245, 250-267, 336-343, 363-378, 385-394, 406-412, 423-440, 443-449, 401-494;서열 번호 60의 aa 18-23, 42-55, 69-77, 85-98, 129-136, 182-188, 214-220, 229-235, 242-248, 251-258, 281-292, 309-316, 333-343, 348-354, 361-367, 393-407, 441-447, 481-488, 493-505, 510-515, 517-527, 530-535, 540-549, 564-583, 593-599, 608-621, 636-645, 656-670, 674-687, 697-708, 726-734, 755-760, 765-772, 785-792, 798-815, 819-824, 826-838, 846-852, 889-904, 907-913, 932-939, 956-964, 982-1000, 1008-1015, 1017-1024, 1028-1034, 1059-1065, 1078-1084, 1122-1129, 1134-1143, 1180-1186, 1188-1194, 1205-1215, 1224-1230, 1276-1283, 1333-1339, 1377-1382, 1415-1421, 1448-1459, 1467-1472, 1537-1545, 1556-1566, 1647-1654, 1666-1675, 1683-1689, 1722-1737, 1740-1754, 1756-1762, 1764-1773, 1775-1783, 1800-1809, 1811-1819, 1839-1851, 1859-1866, 1876-1882, 1930-1939, 1947-1954, 1978-1985, 1999-2007, 2015-2029, 2080-2086, 2094-2100, 2112-2118, 2196-2205, 2232-2243, 198-258, 646-727, 2104-2206;서열 번호 62의 aa 10-29, 46-56, 63-74, 83-105, 107-114, 138-145, 170-184, 186-193, 216-221, 242-248, 277-289, 303-311, 346-360, 379-389, 422-428, 446-453, 459-469, 479-489, 496-501, 83-156;서열 번호 66의 aa 14-22, 32-40, 52-58, 61-77, 81-93, 111-117, 124-138, 151-190, 193-214, 224-244, 253-277, 287-295, 307-324, 326-332, 348-355, 357-362, 384-394, 397-434, 437-460, 489-496, 503-510, 516-522, 528-539, 541-547, 552-558, 563-573, 589-595, 602-624, 626-632, 651-667, 673-689, 694-706, 712- 739, 756-790, 403-462;서열 번호 67의 aa 49-56, 62-68, 83-89, 92-98, 109-115, 124-131, 142-159, 161-167, 169-175, 177-188, 196-224, 230-243, 246-252, 34-46;서열 번호 70의 aa 11-20, 26-47, 69-75, 84-92, 102-109, 119-136, 139-147, 160-170, 178-185, 190-196, 208-215, 225-233, 245-250, 265-272, 277-284, 300-306, 346-357, 373-379, 384-390, 429-435, 471-481, 502-507, 536-561, 663-688, 791-816, 905-910, 919-933, 977-985, 1001-1010, 1052-1057, 1070-1077, 1082-1087, 1094-1112, 493-587, 633-715, 704-760;서열 번호 71의 aa.6-20, 53-63, 83-90, 135-146, 195-208, 244-259, 263-314, 319-327, 337-349, 353-362, 365-374, 380-390, 397-405, 407-415, 208-287, 286-314;서열 번호 72의 aa 10-26, 31-43, 46-58, 61-66, 69-79, 85-92, 100-115, 120-126, 128-135, 149-155, 167-173, 178-187, 189-196, 202-222, 225-231, 233-240, 245-251, 257-263, 271-292, 314-322, 325-334, 339-345, 59-74;서열 번호 73의 aa 4-9, 15-26, 65-76, 108-115, 119-128, 144-153, 38-52, 66-114,서열 번호 74의 aa 5-22, 42-50, 74-81, 139-145, 167-178, 220-230, 246-253, 255-264, 137-237, 250-267;서열 번호 75의 aa 10-26, 31-44, 60-66, 99-104, 146-153, 163-169, 197-205, 216-223, 226-238, 241-258, 271-280, 295-315, 346-351, 371-385, 396-407, 440-446, 452-457, 460-466, 492-510, 537-543, 546-551, 565-582, 590-595, 635-650, 672-678, 686-701, 705-712, 714-721, 725-731, 762-768, 800-805, 672-727;서열 번호 76의 aa 5-32, 35-48, 55-76;서열 번호 77의 aa 7-35, 54-59, 247-261, 263-272, 302-320, 330-339, 368-374, 382-411, 126-143, 168-186;서열 번호 78의 aa 5-24, 88-94, 102-113, 132-143, 163-173, 216-224, 254-269, 273-278, 305-313, 321-327, 334-341, 31-61, 58-74;서열 번호 79의 aa 16-24, 32-39, 43-49, 64-71, 93-99, 126-141, 144-156, 210-218, 226-233, 265-273, 276-284, 158-220;서열 번호 80의 aa 49-72, 76-83, 95-105, 135-146, 148-164, 183-205, 57-128;서열 번호 81의 aa 6-15, 22-32, 58-73, 82-88, 97-109, 120-131, 134-140, 151-163, 179-185, 219-230, 242-255, 271-277, 288-293, 305-319, 345-356, 368-381, 397-406, 408-420, 427-437, 448-454, 473-482, 498-505, 529-535, 550-563, 573-580, 582-590, 600-605, 618-627, 677-685, 718-725, 729-735, 744-759, 773-784, 789-794, 820-837, 902-908, 916-921, 929-935, 949-955, 1001-1008, 1026-1032, 1074-1083, 1088-1094, 1108-1117, 1137-1142, 1159-1177, 1183-1194, 1214-1220, 1236-1252, 1261-1269, 1289-1294, 1311-1329, 1336-1341, 1406-1413, 1419-1432, 1437-1457, 1464-1503, 1519-1525, 1531-1537, 1539-1557, 1560-1567, 1611-1618, 1620-1629, 1697-1704, 1712-1719, 1726-1736, 1781-1786, 1797-1817, 1848- 1854, 1879-1890, 1919-1925, 1946-1953, 1974-1979, 5-134;서열 번호 82의 aa 6-33, 40-46, 51-59, 61-77, 84-104, 112-118, 124-187, 194-248, 252-296, 308-325, 327-361, 367-393, 396-437, 452-479, 484-520, 535-545, 558-574, 582-614, 627-633, 656-663, 671-678, 698-704, 713-722, 725-742, 744-755, 770-784, 786-800, 816-822, 827-837, 483-511,서열 번호 83의 aa 4-19, 57-70, 79-88, 126-132, 144-159, 161-167, 180-198, 200-212, 233-240, 248-255, 276-286, 298-304, 309-323, 332-346, 357-366, 374-391, 394-406, 450-456, 466-473, 479-487, 498-505, 507-519, 521-530, 532-540, 555-565, 571-581, 600-611, 619-625, 634-642, 650-656, 658-665, 676-682, 690-699, 724-733, 740-771, 774-784, 791-797, 808-815, 821-828, 832-838, 876-881, 893-906, 922-929, 938-943, 948-953, 969-976, 1002-1008, 1015-1035, 1056-1069, 1105-1116, 1124-1135, 1144-1151, 1173-1181, 1186-1191, 1206-1215, 1225-1230, 1235-1242, 6-66, 65-124, 590-604;서열 번호 84의 aa 5-32, 66-72, 87-98, 104-112, 116-124, 128-137, 162-168, 174-183, 248-254, 261-266, 289-303, 312-331, 174-249;서열 번호 85의 aa 4-21, 28-40, 45-52, 59-71, 92-107, 123-137, 159-174, 190-202, 220-229, 232-241, 282-296, 302-308, 312-331, 21-118,서열 번호 87의 aa 9-28, 43-48, 56-75, 109-126, 128-141, 143-162, 164-195, 197-216, 234-242, 244-251, 168-181;서열 번호 88의 aa 4-10, 20-42, 50-86, 88-98, 102-171, 176-182, 189-221, 223-244, 246-268, 276-284, 296-329, 112-188;서열 번호 89의 aa 4-9, 13-24, 26-34, 37-43, 45-51, 59-73, 90-96, 99-113, 160-173, 178-184, 218-228, 233-238, 255-262, 45-105, 103-166, 66-153;서열 번호 90의 aa 13-27, 42-63, 107-191, 198-215, 218-225, 233-250, 474-367;서열 번호 92의 aa 26-53, 95-123, 164-176, 189-199, 8-48;서열 번호 94의 aa 7-13, 15-23, 26-33, 68-81, 84-90, 106-117, 129-137, 140-159, 165-172, 177-230, 234-240, 258-278, 295-319, 22-56, 23-99, 97-115, 233-250, 245-265;서열 번호 95의 aa 13-36, 40-49, 111-118, 134-140, 159-164, 173-183, 208-220, 232-241, 245-254, 262-271, 280-286, 295-301, 303-310, 319-324, 332-339, 1-85, 54-121, 103-185;서열 번호 96의 aa 39-44, 46-80, 92-98, 105-113, 118-123, 133-165, 176-208, 226-238, 240-255, 279-285, 298-330, 338-345, 350-357, 365-372, 397-402, 409-415, 465-473, 488-515, 517-535, 542-550, 554-590, 593-601, 603-620, 627-653, 660-665, 674-687, 698-718, 726-739, 386-402;서열 번호 97의 aa 5-32, 34-49, 1-43;서열 번호 99의 aa 10-27, 37-56, 64-99, 106-119, 121-136, 139-145, 148-178, 190-216, 225-249, 251-276, 292-297, 312-321, 332-399, 403-458, 183-200;서열 번호 100의 aa 5-12, 15-20, 43-49, 94-106, 110-116, 119-128, 153- 163, 175-180, 185-191, 198-209, 244-252, 254-264, 266-273, 280-288, 290-297, 63-126;서열 번호 101의 aa 5-44, 47-55, 62-68, 70-78, 93-100, 128-151, 166-171, 176-308, 1-59;서열 번호 102의 aa 18-28, 36-49, 56-62, 67-84, 86-95, 102-153, 180-195, 198-218, 254-280, 284-296, 301-325, 327-348, 353-390, 397-402, 407-414, 431-455, 328-394;서열 번호 103의 aa 7-37, 56-71, 74-150, 155-162, 183-203, 211-222, 224-234, 242-272, 77-128;서열 번호 104의 aa 34-58, 63-69, 74-86, 92-101, 130-138, 142-150, 158-191, 199-207, 210-221, 234-249, 252-271, 5-48;서열 번호 106의 aa 12-36, 43-50, 58-65, 73-78, 80-87, 108-139, 147-153, 159-172, 190-203, 211-216, 224-232, 234-246, 256-261, 273-279, 286-293, 299-306, 340-346, 354-366, 167-181;서열 번호 112의 aa 61-75, 82-87, 97-104, 113-123, 128-133, 203-216, 224-229, 236-246, 251-258, 271-286, 288-294, 301-310, 316-329, 337-346, 348-371, 394-406, 418-435, 440-452;서열 번호 114의 aa 30-37, 44-55, 83-91, 101-118, 121-128, 136-149, 175-183, 185-193, 206-212, 222-229, 235-242;서열 번호 116의 aa 28-38, 76-91, 102-109, 118-141, 146-153, 155-161, 165-179, 186-202, 215-221, 234-249, 262-269, 276-282, 289-302, 306-314, 321-326, 338-345, 360-369, 385-391;서열 번호 151의 aa 37-42, 57-62, 121-135, 139-145, 183-190, 204-212, 220-227, 242-248, 278-288, 295-30, 304-309, 335-341, 396-404, 412-433, 443-449, 497-503, 505-513, 539-545, 552-558, 601-617, 629-649, 702-711, 736-745, 793-804, 814-829, 843-858, 864-885, 889-895, 905-913, 919-929, 937-943, 957-965, 970-986, 990-1030, 1038-1049, 1063-1072, 1080-1091, 1093-1116, 1126-1136, 1145-1157, 1163-1171, 1177-1183, 1189-1196, 1211-1218, 1225-1235, 1242-1256, 1261-1269, 624-684;서열 번호 152의 aa 8-23, 31-38, 42-49, 61-77, 83-90, 99-108, 110-119, 140-147, 149-155, 159-171, 180-185, 189-209, 228-234, 245-262, 264-275, 280-302, 304-330, 343-360, 391-409, 432-437, 454-463, 467-474, 478-485, 515-528, 532-539, 553-567, 569-581, 586-592, 605-612, 627-635, 639-656, 671-682, 700-714, 731-747, 754-770, 775-791, 797-834, 838-848, 872-891, 927-933, 935-942, 948-968, 976-986, 1000-1007, 1029-1037, 630-700;서열 번호 154의 aa 17-25, 27-55, 84-90, 95-101, 115-121, 55-101;서열 번호 155의 aa 13-28, 40-46, 69-75, 86-92, 114-120, 126-137, 155-172, 182-193, 199-206, 213-221, 232-238, 243-253, 270-276, 284-290, 22-100;서열 번호 158의 aa 7-19, 46-57, 85-91, 110-117, 125-133, 140-149, 156-163, 198-204, 236-251, 269-275, 283-290, 318-323, 347-363, 9-42, 158-174;서열 번호 168의 aa 7-14, 21-30, 34-50, 52-63, 65-72, 77-84, 109-124, 129-152, 158-163, 175-190, 193-216, 219-234;서열 번호 174의 aa 5-24, 38-44, 100-106, 118-130, 144-154, 204-210, 218-223, 228-243, 257-264, 266-286, 292-299;서열 번호 176의 aa 29-44, 74-83, 105-113, 119-125, 130-148, 155-175, 182-190, 198-211, 238-245로 구성되는 군에서 선택되는 (a)의 단편.
- 청구항 1에 있어서, 서열 번호 56의 aa 6-40, 583-598, 620-646, 871-896; 서열 번호 70의 aa 24-53; 서열 번호 74의 aa 240-260; 서열 번호 81의 aa 1660-1682와 1746-1790; 서열 번호 83의 aa 1-29, 680-709, 878-902; 서열 번호 89의 aa 96-136; 서열 번호 94의 aa 1-29, 226-269, 275-326; 서열 번호 114의 aa 23-47, 107-156으로 구성되는 군에서 선택되는 보조 에피토프를 포함하는 것을 특징으로 하는 과다면역 혈청-반응성 항원.
- 스타필로코커스 병원균의 감염 또는 콜로니 형성을 치료하거나 예방하는 백신 제조를 위한 약학 조성물에 있어서, 활성 성분으로 청구항 1 또는 2에 따른 과다면역 혈청-반응성 항원을 함유하는 것을 특징으로 하는 약학 조성물.
- 청구항 3에 있어서, 약학적으로 적합한 담체 또는 부형제를 보조 물질로서 함유하는 것을 특징으로 하는 약학 조성물.
- 청구항 4에 있어서, 약학적으로 적합한 담체 또는 부형제는 면역촉진 화합물인 것을 특징으로 하는 약학 조성물.
- 청구항 5에 있어서, 면역촉진 화합물은 다가양이온 중합체, 면역촉진 데옥시뉴클레오티드(ODN), 알루멘, 프레운드 완전 어쥬번트, 프레운드 불완전 어쥬번트, 신경활성 화합물, 또는 이들의 복합물질에서 선택되는 것을 특징으로 하는 약학 조성물.
- 청구항 1 또는 2에 따른 과다면역 혈청-반응성 항원을 포함하고, 스타필로코커스 병원균의 감염 또는 콜로니 형성을 치료하거나 예방하는 백신.
- 청구항 7에 있어서, 다가양이온 중합체, 면역촉진 데옥시뉴클레오티드(ODN), 알루멘, 프레운드 완전 어쥬번트, 프레운드 불완전 어쥬번트, 신경활성 화합물, 또는 이들의 복합물질에서 선택되는 면역촉진 물질을 추가로 포함하는 것을 특징으로 하는 백신.
- 스타필로코커스 병원균의 감염 또는 콜로니 형성을 치료하거나 예방하는 약제 제조에 사용되는 항체 조성물에 있어서, 청구항 1 또는 2에 따른 과다면역 혈청-반응성 항원 중에서 최소한 하나에 대한 항체를 함유하는 것을 특징으로 하는 항 체 조성물.
- 청구항 9에 있어서, 항체는 단클론 항체인 것을 특징으로 하는 항체 조성물.
- 스타필로코커스 병원균의 감염 또는 콜로니 형성을 치료하거나 예방하는 약제 제조에 사용되는 항체 조성물을 생산하는 방법에 있어서,- 인간이 아닌 동물에 청구항 1 또는 2에 따른 과다면역 혈청-반응성 항원을 투여함으로써 상기 동물에서 면역 반응을 개시하고;- 동물로부터 비장 또는 비장 세포를 떼어내고;- 비장 또는 비장 세포의 하이브리도마 세포를 만들고;- 항원에 특이적인 하이브리도마 세포를 선별하고 클로닝하고;- 클론된 하이브리도마 세포를 배양하고, 선택적으로 추가 정제 단계를 수행하여 항체 조성물을 생산하는 단계로 구성되는 것을 특징으로 하는, 항체 조성물 생산 방법.
- 청구항 11에 있어서, 비장 또는 비장 세포를 떼어내는 단계는 동물을 죽이는 것과 연계되는 것을 특징으로 하는, 항체 조성물 생산 방법.
- 스타필로코커스 병원균의 감염 또는 콜로니 형성을 치료하거나 예방하는 약제 제조에 사용되는 항체 조성물을 생산하는 방법에 있어서,- 인간이 아닌 동물에 청구항 1 또는 2에 따른 과다면역 혈청-반응성 항원을 투여함으로써 상기 동물에서 면역 반응을 개시하고;- 동물로부터 항체-포함 체액을 이전하고;- 항체-포함 체액을 추가로 정제하여 항체 조성물을 생산하는 단계로 구성되는 것을 특징으로 하는, 항체 조성물 생산 방법.
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| ATA130/01 | 2001-01-26 | ||
| AT0013001A AT410798B (de) | 2001-01-26 | 2001-01-26 | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
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| KR1020087006114A KR100901915B1 (ko) | 2001-01-26 | 2002-01-21 | 특이적 병원균에 대한 항원을 동정하고 분리하여 생산하는방법 |
| KR1020037009882A KR100851728B1 (ko) | 2001-01-26 | 2002-01-21 | 특이적 병원균에 대한 항원을 동정하고 분리하여 생산하는 방법 |
| KR1020097017433A KR20090101973A (ko) | 2001-01-26 | 2002-01-21 | 특이적 병원균에 대한 항원을 동정하고 분리하여 생산하는 방법 |
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| KR1020037009882A KR100851728B1 (ko) | 2001-01-26 | 2002-01-21 | 특이적 병원균에 대한 항원을 동정하고 분리하여 생산하는 방법 |
| KR1020097017433A KR20090101973A (ko) | 2001-01-26 | 2002-01-21 | 특이적 병원균에 대한 항원을 동정하고 분리하여 생산하는 방법 |
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| EP (6) | EP1355930B1 (ko) |
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| KR (4) | KR20080107477A (ko) |
| CN (2) | CN101492496A (ko) |
| AT (2) | AT410798B (ko) |
| AU (3) | AU2002247641B8 (ko) |
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| DE (1) | DE60207194T2 (ko) |
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