BG46598A3 - Метод за получаване на алфа-хетероциклично заместени толунитрили - Google Patents

Метод за получаване на алфа-хетероциклично заместени толунитрили

Info

Publication number
BG46598A3
BG46598A3 BG078756A BG7875687A BG46598A3 BG 46598 A3 BG46598 A3 BG 46598A3 BG 078756 A BG078756 A BG 078756A BG 7875687 A BG7875687 A BG 7875687A BG 46598 A3 BG46598 A3 BG 46598A3
Authority
BG
Bulgaria
Prior art keywords
tolunitrile
heterocyclic substituted
obtaining alpha
alpha
obtaining
Prior art date
Application number
BG078756A
Other languages
Bulgarian (bg)
English (en)
Inventor
Robert Bowman
Ronald Steele
Lesllie Browne
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25274596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG46598(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BG46598A3 publication Critical patent/BG46598A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
BG078756A 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили BG46598A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/837,489 US4749713A (en) 1986-03-07 1986-03-07 Alpha-heterocycle substituted tolunitriles

Publications (1)

Publication Number Publication Date
BG46598A3 true BG46598A3 (bg) 1990-01-15

Family

ID=25274596

Family Applications (4)

Application Number Title Priority Date Filing Date
BG078756A BG46598A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили
BG081514A BG45700A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили
BG081515A BG45701A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили
BG098212A BG61204B2 (bg) 1986-03-07 1993-11-11 Алфа-хетероциклени заместени толунитрили

Family Applications After (3)

Application Number Title Priority Date Filing Date
BG081514A BG45700A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили
BG081515A BG45701A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили
BG098212A BG61204B2 (bg) 1986-03-07 1993-11-11 Алфа-хетероциклени заместени толунитрили

Country Status (36)

Country Link
US (1) US4749713A (cs)
EP (1) EP0236940B3 (cs)
JP (1) JPH0755930B2 (cs)
KR (1) KR910000482B1 (cs)
AT (1) ATE94873T1 (cs)
BG (4) BG46598A3 (cs)
CA (1) CA1316928C (cs)
CY (1) CY1905A (cs)
CZ (3) CZ279027B6 (cs)
DD (1) DD264432A5 (cs)
DE (2) DE3787480T2 (cs)
DK (1) DK172190B1 (cs)
DZ (1) DZ1055A1 (cs)
ES (1) ES2059317T3 (cs)
FI (1) FI91857C (cs)
HK (1) HK50296A (cs)
HU (1) HU202843B (cs)
IE (1) IE61101B1 (cs)
IL (1) IL81746A (cs)
LU (1) LU90128I2 (cs)
LV (1) LV5769B4 (cs)
MA (1) MA20888A1 (cs)
MC (1) MC1805A1 (cs)
MT (1) MTP998B (cs)
MX (1) MX5496A (cs)
MY (1) MY102428A (cs)
NL (1) NL970011I2 (cs)
NO (2) NO170277C (cs)
PH (1) PH24159A (cs)
PL (2) PL151490B1 (cs)
PT (1) PT84410B (cs)
RO (2) RO101532B1 (cs)
SK (3) SK151287A3 (cs)
SU (3) SU1470184A3 (cs)
TN (1) TNSN87033A1 (cs)
ZA (1) ZA871637B (cs)

Families Citing this family (49)

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GB8714013D0 (en) * 1987-06-16 1987-07-22 Ici Plc (substituted-aralkyl)heterocyclic compounds
DE3811574A1 (de) * 1988-03-31 1989-10-19 Schering Ag N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
ATE135000T1 (de) * 1989-07-14 1996-03-15 Ciba Geigy Ag Substituierte benzonitrile
DE3926365A1 (de) * 1989-08-04 1991-02-07 Schering Ag Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
JP2602456B2 (ja) * 1990-04-12 1997-04-23 雪印乳業株式会社 子宮内膜症治療剤
EP0457716A1 (de) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalinderivate
DE4039559A1 (de) * 1990-12-07 1992-06-11 Schering Ag Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln
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DE4120107A1 (de) * 1991-06-14 1992-12-17 Schering Ag Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole
US5674886A (en) 1991-09-02 1997-10-07 Yamanouchi Pharmaceutical Co., Ltd. Triazolylated teritiary amine compound or salt thereof
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US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
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EP0891334A1 (en) * 1996-04-03 1999-01-20 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
AU2002342335B2 (en) 2001-05-16 2006-02-02 Novartis Ag Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent
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GB0217636D0 (en) * 2002-07-30 2002-09-11 Novartis Ag Organic compounds
PT1534265E (pt) * 2002-07-30 2007-02-28 Novartis Ag Combinação de um inibidor da aromatase com um bisfosfonato
JP2004196795A (ja) * 2002-12-16 2004-07-15 Wyeth 外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル
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RU2425038C2 (ru) * 2009-11-27 2011-07-27 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Способ получения 1-[ди(4-цианфенил)метил]-1,2,4-триазола
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CA2871359A1 (en) 2012-06-08 2013-12-12 F. Hoffmann-La Roche Ag Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer
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GB201614179D0 (en) 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
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US4602025A (en) * 1984-06-18 1986-07-22 Eli Lilly And Company Aromatase inhibitors

Also Published As

Publication number Publication date
PT84410B (pt) 1989-10-04
EP0236940A2 (en) 1987-09-16
CY1905A (en) 1987-03-05
SK279103B6 (sk) 1998-06-03
SK736887A3 (en) 1998-06-03
LU90128I2 (fr) 1997-10-06
HK50296A (en) 1996-03-29
ATE94873T1 (de) 1993-10-15
SK736787A3 (en) 1998-06-03
NO170277B (no) 1992-06-22
DK117687A (da) 1987-09-08
NO170277C (no) 1992-09-30
NO870937D0 (no) 1987-03-06
SU1470184A3 (ru) 1989-03-30
PL151490B1 (en) 1990-09-28
CZ279026B6 (en) 1994-11-16
NO1998010I1 (no) 1998-03-04
ZA871637B (en) 1987-10-28
JPH0755930B2 (ja) 1995-06-14
PH24159A (en) 1990-03-22
SK279101B6 (sk) 1998-06-03
FI91857C (fi) 1994-08-25
SU1577695A3 (ru) 1990-07-07
PL152025B1 (en) 1990-10-31
BG45701A3 (bg) 1989-07-14
LV5769B4 (lv) 1997-04-20
FI91857B (fi) 1994-05-13
DE3787480D1 (de) 1993-10-28
IL81746A0 (en) 1987-10-20
DK172190B1 (da) 1997-12-22
SK151287A3 (en) 1998-06-03
DK117687D0 (da) 1987-03-06
IL81746A (en) 1992-02-16
DZ1055A1 (fr) 2004-09-13
PL264460A1 (en) 1988-07-21
NL970011I1 (nl) 1997-05-01
TNSN87033A1 (fr) 1990-01-01
CZ279028B6 (en) 1994-11-16
BG61204B2 (bg) 1997-02-28
NO870937L (no) 1987-09-08
EP0236940B1 (en) 1993-09-22
NL970011I2 (nl) 1997-09-01
LV5769A4 (lv) 1996-12-20
EP0236940B3 (en) 2011-03-23
SU1549478A3 (ru) 1990-03-07
CA1316928C (en) 1993-04-27
RO101532B1 (en) 1992-11-03
DE19775016I2 (de) 2002-02-21
BG45700A3 (bg) 1989-07-14
MC1805A1 (fr) 1987-12-22
CS8707368A2 (en) 1991-02-12
KR910000482B1 (ko) 1991-01-25
MTP998B (en) 1987-08-21
US4749713A (en) 1988-06-07
DE3787480T2 (de) 1994-02-24
EP0236940A3 (en) 1989-10-18
ES2059317T3 (es) 1994-11-16
HU202843B (en) 1991-04-29
HUT43822A (en) 1987-12-28
DD264432A5 (de) 1989-02-01
KR870008851A (ko) 1987-10-21
MY102428A (en) 1992-06-30
MA20888A1 (fr) 1987-10-01
RO101533B1 (en) 1992-06-25
AU6976887A (en) 1987-09-10
AU604011B2 (en) 1990-12-06
CS8701512A2 (en) 1991-02-12
CS8707367A2 (en) 1991-02-12
IE870575L (en) 1987-09-07
FI870903A0 (fi) 1987-03-02
SK279102B6 (sk) 1998-06-03
MX5496A (es) 1993-12-01
JPS62212369A (ja) 1987-09-18
CZ279027B6 (en) 1994-11-16
PT84410A (en) 1987-04-01
IE61101B1 (en) 1994-10-05
FI870903L (fi) 1987-09-08

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