US8038994B2
(en)
|
1996-05-15 |
2011-10-18 |
Quest Pharmatech Inc. |
Combination therapy for treating disease
|
PL213213B1
(pl)
*
|
1999-06-25 |
2013-01-31 |
Genentech Inc |
Zastosowanie koniugatu przeciwcialo anty-ErbB- maitansynoid, koniugat przeciwcialo anty-ErbB-maitansynoid i koniugat do zastosowania w sposobie leczenia nowotworu
|
EP1189641B1
(en)
*
|
1999-06-25 |
2009-07-29 |
Genentech, Inc. |
HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES
|
US6949245B1
(en)
|
1999-06-25 |
2005-09-27 |
Genentech, Inc. |
Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
|
US6825333B1
(en)
|
1999-08-20 |
2004-11-30 |
Chiron Corporation |
EGFH2 genes and gene products
|
TR200200472T2
(tr)
|
1999-08-27 |
2002-06-21 |
Genentech, Inc. |
Anti-Erb B2 antikorları ile tedavi için dozajlar
|
CA2385528C
(en)
|
1999-10-01 |
2013-12-10 |
Immunogen, Inc. |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
|
JP2003534292A
(ja)
|
2000-05-19 |
2003-11-18 |
ジェネンテック・インコーポレーテッド |
Erbbアンタゴニスト癌治療に対する有効な応答の可能性を向上させるための遺伝子検出アッセイ
|
EP1228766A1
(en)
*
|
2001-01-31 |
2002-08-07 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
PYK2 phosphorylation by HER3 induces tumor invasion
|
AU2002358246B2
(en)
*
|
2001-10-26 |
2008-02-28 |
Oncoquest Pharmaceuticals Inc. |
Combination therapy for treating disease
|
PL375033A1
(en)
*
|
2002-04-11 |
2005-11-14 |
Amgen, Inc. |
Her-2 receptor tyrosine kinase molecules and uses thereof
|
ITTO20020340A1
(it)
*
|
2002-04-19 |
2003-10-20 |
Biother Di Contardi Gabriella |
Localizzazione del recettore her2 mediante anticorpo umanizzato biotinilato.
|
AU2003237367A1
(en)
|
2002-06-03 |
2003-12-19 |
Chiron Corporation |
Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancer
|
AT413486B
(de)
|
2002-07-03 |
2006-03-15 |
Igeneon Krebs Immuntherapie |
Verwendung eines antikörpers gerichtet gegen lewis-antigene
|
NO340576B1
(no)
*
|
2002-07-11 |
2017-05-15 |
Hoffmann La Roche |
Rekombinant, humanisert antistoff 2C4 (rhuMab 2C4) for anvendelse sammen med et andre, forskjellig vekstinhiberende anti-ErbB2-antistoff i en fremgangsmåte for behandling av kreft i en pasient og anvendelse derav for fremstilling av et medikament
|
WO2004008099A2
(en)
*
|
2002-07-15 |
2004-01-22 |
Genentech, Inc. |
METHODS FOR IDENTIFYING TUMORS THAT ARE RESPONSIVE TO TREATMENT WITH ANTI-ErbB2 ANTIBODIES
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
NZ538284A
(en)
|
2002-07-18 |
2008-04-30 |
Helix Biopharma Corp |
Use of urease and targeting molecule for inhibiting cancer cell growth
|
SI1523496T1
(sl)
|
2002-07-18 |
2011-11-30 |
Merus B V |
Rekombinantno proizvajanje zmesi protiteles
|
US7264800B2
(en)
|
2002-07-18 |
2007-09-04 |
Helix Biopharma Corporation |
Method and composition for inhibiting cancer cell growth
|
KR101115797B1
(ko)
*
|
2002-08-01 |
2012-07-27 |
이뮤노메딕스, 인코오포레이티드 |
알파 태아 단백질 Immu31 항체 및 융합단백질, 및이들의 이용 방법
|
US20040033228A1
(en)
|
2002-08-16 |
2004-02-19 |
Hans-Juergen Krause |
Formulation of human antibodies for treating TNF-alpha associated disorders
|
WO2004032857A2
(en)
*
|
2002-10-08 |
2004-04-22 |
Immunomedics, Inc. |
Antibody therapy
|
WO2004054622A1
(en)
|
2002-12-13 |
2004-07-01 |
Immunomedics, Inc. |
Immunoconjugates with an intracellularly-cleavable linkage
|
CA2518716A1
(en)
*
|
2003-03-11 |
2005-01-13 |
Dana-Farber Cancer Institute |
Inhibition of viral pathogenesis
|
ES2368737T3
(es)
*
|
2003-04-23 |
2011-11-21 |
Medarex, Inc. |
Anticuerpos humanizados contra el receptor de interferon alfa 1 (ifnar-1).
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
AT500651B9
(de)
*
|
2003-05-27 |
2010-04-15 |
Altropus Gmbh |
Aktiv immunisierender antikörper
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
WO2004106375A1
(en)
|
2003-05-30 |
2004-12-09 |
Merus Biopharmaceuticals B.V. I.O. |
Fab library for the preparation of anti vegf and anti rabies virus fabs
|
JP4599355B2
(ja)
|
2003-07-28 |
2010-12-15 |
ジェネンテック, インコーポレイテッド |
プロテインaアフィニティークロマトグラフィーの間のプロテインaの浸出の低減
|
EP1658075A4
(en)
*
|
2003-08-29 |
2008-03-05 |
Cedars Sinai Medical Center |
COMPOSITION AND METHOD FOR THE TREATMENT OF CANCERS AND OTHER PHYSIOLOGICAL DISORDERS BASED ON REGULATION OF THE PPAR-GAMMA PATHWAY AND THE HER-KINASE AXIS
|
WO2005028498A2
(en)
*
|
2003-09-18 |
2005-03-31 |
Raven Biotechnologies, Inc. |
Kid3 and kid3 antibodies that bind thereto
|
WO2005051424A1
(en)
*
|
2003-11-28 |
2005-06-09 |
Mitra Medical Ab |
Targeting of erb antigens
|
RU2402568C2
(ru)
*
|
2004-02-06 |
2010-10-27 |
МорфоСис АГ |
Человеческие анти-cd38-антитела и их применение
|
RU2273475C2
(ru)
*
|
2004-04-06 |
2006-04-10 |
Государственное учреждение системы высшего и послевузовского профессионального образования "Сибирский государственный медицинский университет" (ГУ СВ ПО СибГМУ) |
Способ лечения диссеминированного колоректального рака
|
RU2404810C9
(ru)
*
|
2004-06-01 |
2015-06-20 |
Дженентек, Инк. |
Конъюгаты антитело-лекарственное средство и способы
|
GT200500155A
(es)
*
|
2004-06-16 |
2006-05-15 |
|
Terapia del càncer resistente al platino
|
KR20180004850A
(ko)
|
2004-07-22 |
2018-01-12 |
제넨테크, 인크. |
Her2 항체 조성물
|
US20100111856A1
(en)
|
2004-09-23 |
2010-05-06 |
Herman Gill |
Zirconium-radiolabeled, cysteine engineered antibody conjugates
|
CN101065151B
(zh)
|
2004-09-23 |
2014-12-10 |
健泰科生物技术公司 |
半胱氨酸改造的抗体和偶联物
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
AU2005314127A1
(en)
*
|
2004-12-07 |
2006-06-15 |
Genentech, Inc. |
Selecting patients for therapy with a HER inhibitor
|
EP3698807A1
(en)
|
2005-01-21 |
2020-08-26 |
Genentech, Inc. |
Fixed dosing of her antibodies
|
RU2404806C2
(ru)
|
2005-02-23 |
2010-11-27 |
Дженентек, Инк. |
Продление времени до прогрессирования заболевания или продолжительности жизни у онкологических больных с применением ингибиторов димеризации her
|
AR053272A1
(es)
*
|
2005-05-11 |
2007-04-25 |
Hoffmann La Roche |
Determinacion de responsivos a la quimioterapia
|
EP2186402A1
(en)
|
2005-06-06 |
2010-05-19 |
Genentech, Inc. |
Knock-out animal models for novel genes and methods of use
|
US7700299B2
(en)
|
2005-08-12 |
2010-04-20 |
Hoffmann-La Roche Inc. |
Method for predicting the response to a treatment
|
ZA200800970B
(en)
|
2005-08-15 |
2009-10-28 |
Genentech Inc |
Gene disruptions, compositions and methods relating thereto
|
KR101164820B1
(ko)
|
2005-09-22 |
2012-07-12 |
삼성전자주식회사 |
디스플레이장치
|
US8080534B2
(en)
|
2005-10-14 |
2011-12-20 |
Phigenix, Inc |
Targeting PAX2 for the treatment of breast cancer
|
US20090293137A1
(en)
|
2005-11-21 |
2009-11-26 |
Genentech, Inc. |
Novel Gene Disruptions, Compositions and Methods Relating Thereto
|
AR056857A1
(es)
|
2005-12-30 |
2007-10-24 |
U3 Pharma Ag |
Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
WO2007114979A2
(en)
|
2006-02-17 |
2007-10-11 |
Genentech, Inc. |
Gene disruptons, compositions and methods relating thereto
|
TW200812615A
(en)
|
2006-03-22 |
2008-03-16 |
Hoffmann La Roche |
Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
|
TW200808739A
(en)
|
2006-04-06 |
2008-02-16 |
Novartis Vaccines & Diagnostic |
Quinazolines for PDK1 inhibition
|
EP2082645A1
(en)
|
2006-04-19 |
2009-07-29 |
Genentech, Inc. |
Novel gene disruptions, compositions and methods relating thereto
|
WO2007145862A2
(en)
*
|
2006-06-05 |
2007-12-21 |
Genentech, Inc. |
Extending survival of cancer patients with elevated levels of egf or tgf-alpha
|
US8524865B2
(en)
|
2006-05-30 |
2013-09-03 |
Genentech, Inc. |
Antibodies and immunoconjugates and uses therefor
|
KR101136763B1
(ko)
|
2006-08-21 |
2012-04-24 |
에프. 호프만-라 로슈 아게 |
항-vegf 항체를 이용한 종양 치료 방법
|
WO2008031531A1
(en)
*
|
2006-09-15 |
2008-03-20 |
F. Hoffmann-La Roche Ag |
Tumor therapy with a combination of anti-her2 antibodies
|
JP5687822B2
(ja)
|
2006-10-12 |
2015-03-25 |
中外製薬株式会社 |
抗ereg抗体を用いる癌の診断および治療
|
HUE034263T2
(en)
|
2006-10-27 |
2018-02-28 |
Genentech Inc |
Antibodies and immunoconjugates and their applications
|
EP2899541A1
(en)
|
2007-03-02 |
2015-07-29 |
Genentech, Inc. |
Predicting response to a HER dimerisation inhbitor based on low HER3 expression
|
US9551033B2
(en)
|
2007-06-08 |
2017-01-24 |
Genentech, Inc. |
Gene expression markers of tumor resistance to HER2 inhibitor treatment
|
SI2171090T1
(sl)
|
2007-06-08 |
2013-07-31 |
Genentech, Inc. |
Markerji genskega izraĹľanja tumorske odpornosti na HER2 inhibitorsko zdravljenje
|
US20100254996A1
(en)
*
|
2007-06-18 |
2010-10-07 |
Medimmune, Llc |
Synergistic treatment of cells that express epha2 and erbb2
|
RU2557319C2
(ru)
|
2007-07-16 |
2015-07-20 |
Дженентек, Инк. |
ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА ПРОТИВ CD79b И ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ПРИМЕНЕНИЯ
|
DK2474557T3
(da)
|
2007-07-16 |
2014-11-10 |
Genentech Inc |
Anti-CD79b-antistoffer og immunkonjugater og fremgangsmåder til anvendelse
|
EP2565206B1
(en)
|
2007-10-30 |
2016-03-30 |
Genentech, Inc. |
Antibody purification by cation exchange chromatography
|
KR20100097716A
(ko)
*
|
2007-11-27 |
2010-09-03 |
아블린쓰 엔.브이. |
이종이량체 사이토킨 및/또는 이의 수용체에 대한 아미노산 서열과 이를 포함하는 폴리펩티드
|
PA8809001A1
(es)
|
2007-12-20 |
2009-07-23 |
Novartis Ag |
Compuestos organicos
|
US8454960B2
(en)
|
2008-01-03 |
2013-06-04 |
The Scripps Research Institute |
Multispecific antibody targeting and multivalency through modular recognition domains
|
US8557243B2
(en)
|
2008-01-03 |
2013-10-15 |
The Scripps Research Institute |
EFGR antibodies comprising modular recognition domains
|
CN108864285A
(zh)
|
2008-01-03 |
2018-11-23 |
斯克里普斯研究院 |
通过模块识别结构域的抗体靶向
|
US8557242B2
(en)
|
2008-01-03 |
2013-10-15 |
The Scripps Research Institute |
ERBB2 antibodies comprising modular recognition domains
|
US8574577B2
(en)
|
2008-01-03 |
2013-11-05 |
The Scripps Research Institute |
VEGF antibodies comprising modular recognition domains
|
TWI472339B
(zh)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
包含結合至her2結構域ii之抗體及其酸性變異體的組合物
|
US8722857B2
(en)
|
2008-01-31 |
2014-05-13 |
Genentech, Inc. |
Anti-CD79B antibodies and immunoconjugates and methods of use
|
CN102027135B
(zh)
|
2008-03-14 |
2015-04-22 |
健泰科生物技术公司 |
与药物抗性有关的遗传变异
|
SI2644194T1
(sl)
*
|
2008-03-18 |
2017-08-31 |
Genentech, Inc. |
Kombinacije konjugata protitelo proti HER2-zdravilo in docetaksela
|
PL2789684T3
(pl)
|
2008-05-23 |
2017-06-30 |
Siwa Corporation |
Sposoby i kompozycje do ułatwiania regeneracji
|
BRPI0812682A2
(pt)
|
2008-06-16 |
2010-06-22 |
Genentech Inc |
tratamento de cáncer de mama metastático
|
BRPI0918978A2
(pt)
|
2008-09-10 |
2015-12-01 |
Genentech Inc |
composições e métodos a prevenção da degradação oxidativa das proteínas
|
HUE062339T2
(hu)
|
2009-02-13 |
2023-10-28 |
Immunomedics Inc |
Sejten belül hasítható kötést tartalmazó immunkonjugátumok
|
CN102356092B
(zh)
|
2009-03-20 |
2014-11-05 |
霍夫曼-拉罗奇有限公司 |
双特异性抗-her抗体
|
SG174992A1
(en)
|
2009-04-01 |
2011-11-28 |
Genentech Inc |
Anti-fcrh5 antibodies and immunoconjugates and methods of use
|
CA2757669A1
(en)
|
2009-04-07 |
2010-10-14 |
Roche Glycart Ag |
Bispecific anti-erbb-1/anti-c-met antibodies
|
CN102421448A
(zh)
|
2009-05-29 |
2012-04-18 |
霍夫曼-拉罗奇有限公司 |
Her2信号传导调控剂在表达her2的胃癌患者中
|
WO2010137654A1
(ja)
|
2009-05-29 |
2010-12-02 |
株式会社未来創薬研究所 |
Egfファミリーリガンドのアンタゴニストを成分とする医薬組成物
|
US8293753B2
(en)
|
2009-07-02 |
2012-10-23 |
Novartis Ag |
Substituted 2-carboxamide cycloamino ureas
|
US9345661B2
(en)
|
2009-07-31 |
2016-05-24 |
Genentech, Inc. |
Subcutaneous anti-HER2 antibody formulations and uses thereof
|
AU2010282733B2
(en)
|
2009-08-11 |
2016-07-14 |
Genentech, Inc. |
Production of proteins in glutamine-free cell culture media
|
TW201431558A
(zh)
*
|
2009-08-15 |
2014-08-16 |
建南德克公司 |
用於治療先前治療過之乳癌之抗-血管新生療法
|
KR101764449B1
(ko)
|
2009-09-01 |
2017-08-02 |
제넨테크, 인크. |
변형된 단백질 a 용리를 통한 증진된 단백질 정제
|
AR078161A1
(es)
|
2009-09-11 |
2011-10-19 |
Hoffmann La Roche |
Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
|
PL2486141T3
(pl)
|
2009-10-07 |
2018-07-31 |
Macrogenics, Inc. |
Polipeptydy zawierające regiony fc i mające w wyniku zmian w zakresie fukozylacji ulepszoną funkcję efektorową, i sposoby zastosowania tych polipeptydów
|
WO2011059762A1
(en)
*
|
2009-10-28 |
2011-05-19 |
Abbott Biotherapeutics Corp. |
Anti-egfr antibodies and their uses
|
CN102933600B
(zh)
|
2009-11-05 |
2015-11-25 |
弗·哈夫曼-拉罗切有限公司 |
分泌异源多肽的方法和组合物
|
SMT202000267T1
(it)
|
2009-11-13 |
2020-07-08 |
Amgen Inc |
Materiali e metodi per trattare o prevenire malattie associate a her-3
|
RU2580038C2
(ru)
|
2009-12-04 |
2016-04-10 |
Дженентек, Инк. |
Мультиспецифические антитела, аналоги антител, композиции и способы
|
RU2607366C2
(ru)
*
|
2010-02-04 |
2017-01-10 |
Торэй Индастриз, Инк. |
Фармацевтическая композиция для лечения и/или профилактики рака
|
EP2536748B1
(en)
|
2010-02-18 |
2014-08-20 |
Genentech, Inc. |
Neuregulin antagonists and use thereof in treating cancer
|
US8609095B2
(en)
|
2010-03-04 |
2013-12-17 |
Symphogen A/S |
Anti-HER2 antibodies and compositions
|
KR101878369B1
(ko)
|
2010-03-22 |
2018-07-16 |
제넨테크, 인크. |
단백질-함유 제제의 안정화에 유용한 조성물 및 방법
|
RU2012151500A
(ru)
|
2010-05-03 |
2014-06-10 |
Дженентек, Инк. |
Композиции и способы, пригодные для снижения вязкости белковосодержащих составов
|
WO2011146568A1
(en)
|
2010-05-19 |
2011-11-24 |
Genentech, Inc. |
Predicting response to a her inhibitor
|
NZ604007A
(en)
|
2010-05-27 |
2015-03-27 |
Genmab As |
Monoclonal antibodies against her2 epitope
|
CA3051311A1
(en)
|
2010-05-27 |
2011-12-01 |
Genmab A/S |
Monoclonal antibodies against her2
|
HUE030820T2
(en)
|
2010-05-28 |
2017-06-28 |
Hoffmann La Roche |
Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
|
NZ701208A
(en)
|
2010-06-03 |
2016-05-27 |
Genentech Inc |
Immuno-pet imaging of antibodies and immunoconjugates and uses thereof
|
CA2799540A1
(en)
|
2010-06-08 |
2011-12-15 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
ES2880802T3
(es)
|
2010-06-24 |
2021-11-25 |
Hoffmann La Roche |
Composiciones y procedimientos para estabilizar formulaciones que contienen proteínas
|
US20120100166A1
(en)
|
2010-07-15 |
2012-04-26 |
Zyngenia, Inc. |
Ang-2 Binding Complexes and Uses Thereof
|
AR082418A1
(es)
|
2010-08-02 |
2012-12-05 |
Novartis Ag |
Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
|
TW201302793A
(zh)
|
2010-09-03 |
2013-01-16 |
Glaxo Group Ltd |
新穎之抗原結合蛋白
|
US8721571B2
(en)
|
2010-11-22 |
2014-05-13 |
Siwa Corporation |
Selective removal of cells having accumulated agents
|
EP2643353A1
(en)
|
2010-11-24 |
2013-10-02 |
Novartis AG |
Multispecific molecules
|
CA2820095C
(en)
|
2010-12-21 |
2019-02-26 |
F. Hoffmann-La Roche Ag |
Isoform enriched antibody preparation and method for obtaining it
|
JP5766296B2
(ja)
|
2010-12-23 |
2015-08-19 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
|
CA2817448C
(en)
|
2010-12-23 |
2019-01-22 |
F. Hoffmann-La Roche Ag |
Binding agent
|
TW201309700A
(zh)
|
2011-01-31 |
2013-03-01 |
Novartis Ag |
新穎雜環衍生物
|
US9133270B2
(en)
|
2011-03-08 |
2015-09-15 |
The Trustees Of The University Of Pennsylvania |
Antibody-like proteins for therapeutic and diagnostic use
|
AU2012245116A1
(en)
|
2011-04-20 |
2013-11-07 |
Genmab A/S |
Bispecific antibodies against HER2 and CD3
|
DK2714738T3
(en)
|
2011-05-24 |
2019-01-28 |
Zyngenia Inc |
MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS
|
CA2842375A1
(en)
|
2011-08-17 |
2013-02-21 |
Erica Jackson |
Neuregulin antibodies and uses thereof
|
ES3023516T3
(en)
|
2011-10-14 |
2025-06-02 |
Hoffmann La Roche |
Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab
|
US9327023B2
(en)
|
2011-10-25 |
2016-05-03 |
The Regents Of The University Of Michigan |
HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
|
EP2771342B1
(en)
|
2011-10-28 |
2016-05-18 |
Novartis AG |
Purine derivatives and their use in the treatment of disease
|
JP6180425B2
(ja)
|
2011-11-23 |
2017-08-23 |
メディミューン,エルエルシー |
Her3に特異的な結合分子及びそれらの使用
|
CN104271761B
(zh)
|
2011-11-30 |
2017-03-15 |
霍夫曼-拉罗奇有限公司 |
癌症中的erbb3突变
|
US9376715B2
(en)
|
2011-12-09 |
2016-06-28 |
Roche Molecular Systems, Inc |
Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene
|
KR102067075B1
(ko)
|
2011-12-22 |
2020-01-17 |
제넨테크, 인크. |
이온 교환 막 크로마토그래피
|
TWI593705B
(zh)
|
2011-12-28 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
|
CA2863287A1
(en)
|
2012-01-31 |
2013-08-08 |
Smithkline Beecham (Cork) Limited |
Method of treating cancer
|
EP2638916A1
(en)
|
2012-03-16 |
2013-09-18 |
Covagen AG |
Novel binding molecules with antitumoral activity
|
MX2014011500A
(es)
|
2012-03-27 |
2014-12-05 |
Genentech Inc |
Diagnosticos y tratamientos relacionados a inhibidores her3.
|
EA035344B1
(ru)
|
2012-04-20 |
2020-05-29 |
Мерюс Н.В. |
Способ получения двух антител из одной клетки-хозяина
|
KR101505157B1
(ko)
|
2012-05-08 |
2015-03-24 |
주식회사 종근당 |
항―ErbB2 항체 변이체
|
CN104349779A
(zh)
|
2012-05-16 |
2015-02-11 |
诺华股份有限公司 |
Pi-3激酶抑制剂的剂量方案
|
BR112015012644A2
(pt)
|
2012-11-30 |
2017-12-19 |
Hoffmann La Roche |
método para determinar a necessidade de um paciente com câncer, método de tratamento do câncer, composição farmacêutica, uso de um ácido nucleico ou anticorpo e kit;
|
WO2014108858A1
(en)
|
2013-01-10 |
2014-07-17 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Fatty acid synthase inhibitors
|
US9180185B2
(en)
|
2013-01-11 |
2015-11-10 |
Hoffman-La Roche Inc. |
Combination therapy of anti-HER3 antibodies
|
EA038918B1
(ru)
|
2013-03-15 |
2021-11-09 |
Зинджения, Инк. |
Пептид, связывающий рецептор эпидермального фактора роста, мультиспецифические комплексы, содержащие пептид и антитела, и их применение
|
CN104628846B
(zh)
|
2013-11-06 |
2019-12-06 |
三生国健药业(上海)股份有限公司 |
重组蛋白质的纯化方法
|
KR101936697B1
(ko)
|
2013-11-19 |
2019-01-10 |
레메젠 리미티드 |
항-her2 항체 및 이의 접합체
|
DK3074424T3
(da)
|
2013-11-27 |
2025-05-19 |
Zymeworks Bc Inc |
Bispecifikke antigenbindende konstrukter målrettet her2
|
CA2930359C
(en)
|
2013-12-06 |
2022-03-01 |
Novartis Ag |
Dosage regimen for an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor
|
IL278891B2
(en)
|
2014-01-31 |
2024-06-01 |
Daiichi Sankyo Co Ltd |
Anti-HER2 drug-antibody conjugates, preparations containing them and their uses
|
US20160361309A1
(en)
|
2014-02-26 |
2016-12-15 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Methods of treating cancer patients responding to ezh2 inhibitor gsk126
|
BR112016020822A2
(pt)
|
2014-03-14 |
2017-10-03 |
Genentech Inc |
Métodos e composições para secreção de polipeptídeos heterólogos
|
TW201542594A
(zh)
|
2014-04-11 |
2015-11-16 |
Medimmune Llc |
雙特異性her2抗體
|
KR20170052600A
(ko)
|
2014-09-12 |
2017-05-12 |
제넨테크, 인크. |
시스테인 가공된 항체 및 콘주게이트
|
WO2016044252A2
(en)
|
2014-09-19 |
2016-03-24 |
Siwa Corporation |
Anti-age antibodies for treating inflammation and auto-immune disorders
|
US10385380B2
(en)
|
2014-10-02 |
2019-08-20 |
The Regents Of The University Of California |
Personalized protease assay to measure protease activity in neoplasms
|
WO2016082044A1
(en)
|
2014-11-27 |
2016-06-02 |
Zymeworks Inc. |
Methods of using bispecific antigen-binding constructs targeting her2
|
US10358502B2
(en)
|
2014-12-18 |
2019-07-23 |
Siwa Corporation |
Product and method for treating sarcopenia
|
US9993535B2
(en)
|
2014-12-18 |
2018-06-12 |
Siwa Corporation |
Method and composition for treating sarcopenia
|
MA41414A
(fr)
|
2015-01-28 |
2017-12-05 |
Centre Nat Rech Scient |
Protéines de liaison agonistes d' icos
|
KR101515535B1
(ko)
|
2015-01-28 |
2015-05-06 |
주식회사 종근당 |
항―ErbB2 항체 변이체
|
WO2016179707A1
(en)
*
|
2015-05-13 |
2016-11-17 |
Zymeworks Inc. |
Antigen-binding constructs targeting her2
|
EP3331919A1
(en)
|
2015-08-07 |
2018-06-13 |
GlaxoSmithKline Intellectual Property Development Limited |
Combination therapy comprising anti ctla-4 antibodies
|
EP3362483A1
(en)
*
|
2015-10-13 |
2018-08-22 |
Siwa Corporation |
Anti-age antibodies and methods of use thereof
|
HK1252411A1
(zh)
|
2015-11-02 |
2019-05-24 |
Novartis Ag |
磷脂酰肌醇3-激酶抑制劑的給藥方案
|
CN106729743B
(zh)
|
2015-11-23 |
2021-09-21 |
四川科伦博泰生物医药股份有限公司 |
抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用
|
US20190256608A1
(en)
|
2015-12-01 |
2019-08-22 |
Glaxosmithkline Intellectual Property Development Limited |
Combination treatments and uses and methods thereof
|
KR102424513B1
(ko)
|
2015-12-14 |
2022-07-25 |
마크로제닉스, 인크. |
Pd-1 및 ctla-4과의 면역반응성을 가진 이중특이적 분자, 및 이것의 사용 방법
|
CN105646704B
(zh)
*
|
2015-12-28 |
2019-11-15 |
广西医科大学 |
抗p185erbB2人鼠嵌合抗体ChAb26、乳腺特异性表达载体、转基因FVB小鼠及其制备方法
|
CA3021150C
(en)
|
2016-02-19 |
2023-02-07 |
Siwa Corporation |
Method and composition for treating cancer, killing metastatic cancer cells and preventing cancer metastasis using antibody to advanced glycation end products (age)
|
KR20180119570A
(ko)
*
|
2016-03-15 |
2018-11-02 |
메리맥 파마슈티컬즈, 인크. |
항-ErbB3 항체를 포함하는 병용 요법을 이용한 ER+, HER2-, HRG+ 유방암의 치료
|
CA3057829A1
(en)
|
2016-04-15 |
2017-10-19 |
Siwa Corporation |
Anti-age antibodies for treating neurodegenerative disorders
|
WO2017194554A1
(en)
|
2016-05-10 |
2017-11-16 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Combinations therapies for the treatment of cancer
|
CN109476744B
(zh)
*
|
2016-05-12 |
2023-04-11 |
新加坡科技研究局 |
抗erbb-2抗体及其用途
|
WO2017222535A1
(en)
|
2016-06-23 |
2017-12-28 |
Siwa Corporation |
Vaccines for use in treating various diseases and disorders
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
KR20230158641A
(ko)
|
2016-10-07 |
2023-11-20 |
다이이찌 산쿄 가부시키가이샤 |
항 her2 항체-약물 콘주게이트 투여에 의한 내성암의 치료
|
CA3046293A1
(en)
|
2016-12-12 |
2018-06-21 |
Daiichi Sankyo Company, Limited |
Combination of antibody-drug conjugate and immune checkpoint inhibitor
|
US10858449B1
(en)
|
2017-01-06 |
2020-12-08 |
Siwa Corporation |
Methods and compositions for treating osteoarthritis
|
JP7069476B2
(ja)
*
|
2017-01-06 |
2022-05-18 |
博奥信生物技▲術▼(南京)有限公司 |
ErbB2抗体およびその使用
|
US10925937B1
(en)
|
2017-01-06 |
2021-02-23 |
Siwa Corporation |
Vaccines for use in treating juvenile disorders associated with inflammation
|
US10961321B1
(en)
|
2017-01-06 |
2021-03-30 |
Siwa Corporation |
Methods and compositions for treating pain associated with inflammation
|
US10995151B1
(en)
|
2017-01-06 |
2021-05-04 |
Siwa Corporation |
Methods and compositions for treating disease-related cachexia
|
KR102585848B1
(ko)
|
2017-02-24 |
2023-10-11 |
마크로제닉스, 인크. |
Cd137 및 종양 항원에 결합할 수 있는 이중특이적 결합 분자, 및 그것의 용도
|
DK3589661T5
(da)
|
2017-03-02 |
2024-09-02 |
Genentech Inc |
Adjuvansbehandling af HER2-positiv brystcancer
|
TW201834649A
(zh)
|
2017-03-02 |
2018-10-01 |
新加坡商亞獅康私人有限公司 |
癌症療法
|
BR112019019706A2
(pt)
|
2017-03-22 |
2020-04-28 |
Genentech Inc |
conjugado de anticorpo, anticorpo, composição farmacêutica, métodos para reduzir ou inibir angiogênese e para tratar um distúrbio ocular
|
CA3059803A1
(en)
|
2017-04-13 |
2018-10-18 |
Siwa Corporation |
Humanized monoclonal advanced glycation end-product antibody
|
WO2018222135A1
(en)
|
2017-06-02 |
2018-12-06 |
Aslan Pharmaceuticals Pte Ltd |
Cancer therapy
|
CN107417791B
(zh)
*
|
2017-08-17 |
2020-09-22 |
合肥瀚科迈博生物技术有限公司 |
抗人ErbB2双特异性抗体、其制备方法及用途
|
CN118743764A
(zh)
|
2017-08-23 |
2024-10-08 |
第一三共株式会社 |
抗体-药物缀合物制剂及其冻干
|
CN117865839A
(zh)
|
2017-08-31 |
2024-04-12 |
第一三共株式会社 |
制备抗体-药物缀合物的新方法
|
US11945882B2
(en)
|
2017-08-31 |
2024-04-02 |
Daiichi Sankyo Company, Limited |
Method for producing antibody-drug conjugate
|
CN107789631B
(zh)
*
|
2017-11-03 |
2021-03-16 |
合肥瀚科迈博生物技术有限公司 |
抗人ErbB2双表位抗体-药物偶联物及其应用
|
SG11202005557TA
(en)
|
2017-12-12 |
2020-07-29 |
Macrogenics Inc |
Bispecific cd 16-binding molecules and their use in the treatment of disease
|
US11518801B1
(en)
|
2017-12-22 |
2022-12-06 |
Siwa Corporation |
Methods and compositions for treating diabetes and diabetic complications
|
SG11202007572VA
(en)
|
2018-02-15 |
2020-09-29 |
Macrogenics Inc |
Variant cd3-binding domains and their use in combination therapies for the treatment of disease
|
EP3560945A1
(en)
|
2018-04-27 |
2019-10-30 |
F. Hoffmann-La Roche AG |
Methods for purification of polypeptides using polysorbates
|
US20210205466A1
(en)
|
2018-05-28 |
2021-07-08 |
Daiichi Sankyo Company, Limited |
Treatment of her2-mutated cancer by administering anti-her2 antibody-drug conjugate
|
MX2021000908A
(es)
|
2018-07-23 |
2021-06-08 |
Trevi Therapeutics Inc |
Tratamiento de la tos cronica, la dificultad respiratoria y la disnea.
|
AU2019311557A1
(en)
|
2018-07-25 |
2021-02-04 |
Daiichi Sankyo Company, Limited |
Effective method for manufacturing antibody-drug conjugate
|
EP3831853A4
(en)
|
2018-07-27 |
2022-06-01 |
Daiichi Sankyo Company, Limited |
Protein recognizing drug moiety of antibody-drug conjugate
|
EA202190403A1
(ru)
|
2018-07-31 |
2021-05-24 |
Дайити Санкио Компани, Лимитед |
Лечение метастатической опухоли головного мозга путем введения конъюгата антитело-лекарственное средство
|
AU2019320336B2
(en)
|
2018-08-06 |
2025-06-05 |
Daiichi Sankyo Company, Limited |
Combination of antibody-drug conjugate and tubulin inhibitor
|
US12312641B2
(en)
|
2018-08-23 |
2025-05-27 |
Daiichi Sankyo Company, Limited |
Sensitivity marker for antibody-drug conjugate
|
CA3114395A1
(en)
|
2018-09-25 |
2020-04-02 |
Absci, Llc |
Protein purification methods
|
WO2020084503A1
(en)
|
2018-10-26 |
2020-04-30 |
Cadila Healthcare Limited |
A composition comprising antibody with reduced level of basic variants thereof
|
TW202034959A
(zh)
|
2018-12-11 |
2020-10-01 |
日商第一三共股份有限公司 |
抗體-藥物結合物與parp抑制劑之組合
|
JP7624922B2
(ja)
|
2018-12-19 |
2025-01-31 |
インサイト・コーポレイション |
胃腸疾患の治療のためのjak1経路阻害剤
|
BR112021011894A2
(pt)
|
2018-12-21 |
2021-09-08 |
Daiichi Sankyo Company, Limited |
Composição farmacêutica
|
US20220098303A1
(en)
|
2019-02-01 |
2022-03-31 |
Glaxosmithkline Intellectual Property Development Limited |
Combination treatments for cancer comprising belantamab mafodotin and an anti ox40 antibody and uses and methods thereof
|
JP7589168B2
(ja)
|
2019-04-01 |
2024-11-25 |
ジェネンテック, インコーポレイテッド |
タンパク質含有製剤を安定化するための組成物および方法
|
CN112007169B
(zh)
*
|
2019-05-30 |
2022-03-08 |
湖南大学 |
一种核酸适配体药物偶联物及其制备方法和用途
|
CN110205302B
(zh)
*
|
2019-06-24 |
2021-03-23 |
扬州大学 |
一株分泌抗麦考酚酸单克隆抗体的细胞株、其单克隆抗体及其应用
|
AU2020308053A1
(en)
|
2019-06-26 |
2022-01-20 |
Glaxosmithkline Intellectual Property Development Limited |
IL1RAP binding proteins
|
CN110551214A
(zh)
*
|
2019-08-27 |
2019-12-10 |
杨澜 |
一种人源化抗Periostin单克隆抗体、及其制备方法和应用
|
KR20220127849A
(ko)
|
2020-01-10 |
2022-09-20 |
트레비 테라퓨틱스, 인코포레이티드 |
날부핀의 투여 방법
|
WO2021152495A1
(en)
|
2020-01-28 |
2021-08-05 |
Glaxosmithkline Intellectual Property Development Limited |
Combination treatments and uses and methods thereof
|
WO2021260578A1
(en)
|
2020-06-24 |
2021-12-30 |
Astrazeneca Uk Limited |
Combination of antibody-drug conjugate and cdk9 inhibitor
|
US20230256110A1
(en)
|
2020-06-24 |
2023-08-17 |
Astrazeneca Uk Limited |
Combination of antibody-drug conjugate and atm inhibitor
|
WO2021260582A1
(en)
|
2020-06-24 |
2021-12-30 |
Astrazeneca Uk Limited |
Combination of antibody-drug conjugate and aurora b inhibitor
|
WO2021260583A1
(en)
|
2020-06-24 |
2021-12-30 |
Astrazeneca Uk Limited |
Combination of antibody-drug conjugate and dna-pk inhibitor
|
MX2022016375A
(es)
|
2020-06-24 |
2023-04-04 |
Astrazeneca Uk Ltd |
Combinación de conjugado de anticuerpo-fármaco e inhibidor de la cinasa relacionada con ataxia telangiectasia y rad3 (atr).
|
US20230293714A1
(en)
|
2020-07-20 |
2023-09-21 |
Daiichi Sankyo Company, Limited |
Combination of anti-her2 antibody-drug conjugate with her dimerization inhibitor
|
CN116348115A
(zh)
|
2020-10-09 |
2023-06-27 |
阿斯利康(英国)有限公司 |
抗体-药物缀合物和parp1选择性抑制剂的组合
|
IL302812A
(en)
|
2020-11-11 |
2023-07-01 |
Daiichi Sankyo Co Ltd |
Combinations of an antibody-drug conjugate with anti-sirp alpha antibody
|
IL312728A
(en)
|
2021-11-30 |
2024-07-01 |
Daiichi Sankyo Co Ltd |
Protease-cleavable masked antibodies
|
US20250161305A1
(en)
|
2021-12-28 |
2025-05-22 |
Astrazeneca Uk Limited |
Combination of antibody-drug conjugate and rasg12c inhibitor
|
TW202342106A
(zh)
|
2022-02-09 |
2023-11-01 |
日商第一三共股份有限公司 |
環境應答性遮蔽抗體及其利用
|
JP2025513620A
(ja)
|
2022-04-27 |
2025-04-24 |
第一三共株式会社 |
抗体-薬物コンジュゲートとezh1阻害剤および/またはezh2阻害剤との組合せ
|
JP2025517656A
(ja)
|
2022-05-11 |
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