AU710105B2 - (-)-(3R0-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy) butyric acid as cellular adhesion inhibitor - Google Patents

(-)-(3R0-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy) butyric acid as cellular adhesion inhibitor Download PDF

Info

Publication number
AU710105B2
AU710105B2 AU58272/96A AU5827296A AU710105B2 AU 710105 B2 AU710105 B2 AU 710105B2 AU 58272/96 A AU58272/96 A AU 58272/96A AU 5827296 A AU5827296 A AU 5827296A AU 710105 B2 AU710105 B2 AU 710105B2
Authority
AU
Australia
Prior art keywords
pharmaceutically
optically active
active compound
ester
amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU58272/96A
Other languages
English (en)
Other versions
AU5827296A (en
Inventor
Stuart Dennett Mills
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/457,538 external-priority patent/US5652242A/en
Priority claimed from GBGB9518188.9A external-priority patent/GB9518188D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of AU5827296A publication Critical patent/AU5827296A/en
Application granted granted Critical
Publication of AU710105B2 publication Critical patent/AU710105B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU58272/96A 1995-06-01 1996-05-28 (-)-(3R0-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy) butyric acid as cellular adhesion inhibitor Ceased AU710105B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/457538 1995-06-01
US08/457,538 US5652242A (en) 1993-03-29 1995-06-01 Heterocyclic derivatives
GBGB9518188.9A GB9518188D0 (en) 1995-09-07 1995-09-07 Optically active derivative
GB9518188 1995-09-07
PCT/GB1996/001260 WO1996038416A1 (en) 1995-06-01 1996-05-28 (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor

Publications (2)

Publication Number Publication Date
AU5827296A AU5827296A (en) 1996-12-18
AU710105B2 true AU710105B2 (en) 1999-09-16

Family

ID=26307696

Family Applications (1)

Application Number Title Priority Date Filing Date
AU58272/96A Ceased AU710105B2 (en) 1995-06-01 1996-05-28 (-)-(3R0-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy) butyric acid as cellular adhesion inhibitor

Country Status (31)

Country Link
EP (1) EP0796247A1 (da)
JP (1) JP2885941B2 (da)
KR (1) KR100245957B1 (da)
AT (1) AT406675B (da)
AU (1) AU710105B2 (da)
BE (1) BE1009520A5 (da)
BR (1) BR9606409A (da)
CA (1) CA2194397A1 (da)
CH (1) CH691808A5 (da)
CZ (1) CZ26997A3 (da)
DE (1) DE19680509T1 (da)
DK (1) DK10697A (da)
ES (1) ES2137886B1 (da)
FI (1) FI970393A (da)
GB (1) GB2304340B (da)
GR (1) GR1002702B (da)
HU (1) HUP9700274A3 (da)
IE (1) IE960405A1 (da)
IL (1) IL118477A0 (da)
IT (1) IT1290839B1 (da)
LU (1) LU90008B1 (da)
MC (1) MC2418A1 (da)
MX (1) MX9700379A (da)
NL (1) NL1003243C2 (da)
NO (1) NO307460B1 (da)
NZ (1) NZ308597A (da)
PL (1) PL318440A1 (da)
SE (1) SE510812C2 (da)
SK (1) SK13097A3 (da)
TR (1) TR199700020T1 (da)
WO (1) WO1996038416A1 (da)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022834A1 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic derivatives as platelet aggregation inhibitors
WO1994022835A2 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022834A1 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic derivatives as platelet aggregation inhibitors
WO1994022835A2 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors

Also Published As

Publication number Publication date
MC2418A1 (fr) 1997-05-23
NO970437D0 (no) 1997-01-31
FI970393A0 (fi) 1997-01-30
BR9606409A (pt) 1997-09-30
TR199700020T1 (tr) 1997-04-22
HUP9700274A3 (en) 2000-02-28
NO307460B1 (no) 2000-04-10
HU9700274D0 (en) 1997-04-28
GR1002702B (el) 1997-05-22
FI970393A (fi) 1997-01-30
ITMI961113A0 (it) 1996-05-31
DE19680509T1 (de) 1997-12-04
NO970437L (no) 1997-02-20
LU90008B1 (fr) 1997-04-16
JP2885941B2 (ja) 1999-04-26
ES2137886B1 (es) 2000-08-16
AU5827296A (en) 1996-12-18
MX9700379A (es) 1997-04-30
ATA900596A (de) 1999-12-15
CH691808A5 (de) 2001-10-31
SE9700203D0 (sv) 1997-01-24
NZ308597A (en) 1998-11-25
SE9700203L (sv) 1997-01-24
SK13097A3 (en) 1997-08-06
ITMI961113A1 (it) 1997-12-01
PL318440A1 (en) 1997-06-09
GB2304340A (en) 1997-03-19
KR100245957B1 (ko) 2000-04-01
WO1996038416A1 (en) 1996-12-05
HUP9700274A2 (hu) 1999-06-28
IE960405A1 (en) 1996-12-11
GB9627127D0 (en) 1997-02-19
IL118477A0 (en) 1996-09-12
CZ26997A3 (en) 1997-08-13
GB2304340B (en) 1998-07-29
JPH09512836A (ja) 1997-12-22
SE510812C2 (sv) 1999-06-28
BE1009520A5 (fr) 1997-04-01
EP0796247A1 (en) 1997-09-24
NL1003243C2 (nl) 1996-12-04
KR970704689A (ko) 1997-09-06
DK10697A (da) 1997-04-01
ES2137886A1 (es) 1999-12-16
CA2194397A1 (en) 1996-12-05
IT1290839B1 (it) 1998-12-14
AT406675B (de) 2000-07-25

Similar Documents

Publication Publication Date Title
DE69116285T2 (de) Fibrinogen-Rezeptor-Antagonisten
US5561148A (en) Adhesion receptor antagonists III
DE68915900T2 (de) Angiogenese hemmendes Mittel.
JP2003514808A (ja) 抗炎症剤としての尿素誘導体
CZ297544B6 (cs) Substituované N-[(aminoiminomethyl)-fenyl]propylamidy nebo N-[(aminomethyl)fenyl]propylamidy
CA2268621A1 (en) 2-pipirazinone-1-acetic acid derivative, production and use thereof
AU758246B2 (en) N,N-substituted cyclic amine derivatives
EP1124824B1 (de) Chromenon- und chromanonderivate als integrinhemmer
KR100300566B1 (ko) 피리미디논유도체와그의제조방법및용도
JPS63139167A (ja) ジヒドロピリジン抗アレルギー及び抗炎症剤
EP1324992A1 (en) Cyclized benzamide neurokinin antagonists for use in therapy
US5134151A (en) 2-picolylamine derivatives
DE69420345T2 (de) Benzothiazolsulfonamid-derivate, verfahren zu deren herstellung und anwendungen
AU710105B2 (en) (-)-(3R0-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy) butyric acid as cellular adhesion inhibitor
DE69813886T2 (de) Naphthalin derivate
FR2758329A1 (fr) Derives d'imidazole-4-butane boronique, leur preparation et leur utilisation en therapeutique
US4963587A (en) Glycine derivative and pharmaceutical preparation thereof
JP2837318B2 (ja) アンジオテンシンｉｉ拮抗性ピリジン誘導体
KR20010075546A (ko) 트롬빈 억제제로서의 벤즈아미드 유도체
JP2858724B2 (ja) 血管新生阻害剤
JPH02243679A (ja) 腫瘍転移阻害剤
MXPA02006904A (es) Fenilamidinas sustituidas, medicinas conteniendo estos compuestos y procedimientos para su preparacion.
RU2339634C2 (ru) Кристаллическая форма
US5675011A (en) Process for producing pyrrolidine derivative and salt thereof
FR2734818A1 (fr) Acide (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazine-1-yl- phenoxy}-butyrique, procede pour sa preparation et composition pharmaceutique le contenant

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired