GB2304340A - (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor - Google Patents
(-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitorInfo
- Publication number
- GB2304340A GB2304340A GB9627127A GB9627127A GB2304340A GB 2304340 A GB2304340 A GB 2304340A GB 9627127 A GB9627127 A GB 9627127A GB 9627127 A GB9627127 A GB 9627127A GB 2304340 A GB2304340 A GB 2304340A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyridyl
- methyl
- butyric acid
- phenoxy
- cellular adhesion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Abstract
The novel optically active compound (-)-(3R)-3-methyl-4--4-[4-(4-pyridyl)-piperazine-1-yl]phenoxy butyric acid, and pharmaceutically-acceptable salts, esters, amides or solvates thereof. Processes for the preparation of the compound, pharmaceutical compositions containing the compound and its use to inhibit cellular adhesion, for example platelet aggregation.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/457,538 US5652242A (en) | 1993-03-29 | 1995-06-01 | Heterocyclic derivatives |
GBGB9518188.9A GB9518188D0 (en) | 1995-09-07 | 1995-09-07 | Optically active derivative |
PCT/GB1996/001260 WO1996038416A1 (en) | 1995-06-01 | 1996-05-28 | (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9627127D0 GB9627127D0 (en) | 1997-02-19 |
GB2304340A true GB2304340A (en) | 1997-03-19 |
GB2304340B GB2304340B (en) | 1998-07-29 |
Family
ID=26307696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9627127A Expired - Fee Related GB2304340B (en) | 1995-06-01 | 1996-05-28 | (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor |
Country Status (31)
Country | Link |
---|---|
EP (1) | EP0796247A1 (en) |
JP (1) | JP2885941B2 (en) |
KR (1) | KR100245957B1 (en) |
AT (1) | AT406675B (en) |
AU (1) | AU710105B2 (en) |
BE (1) | BE1009520A5 (en) |
BR (1) | BR9606409A (en) |
CA (1) | CA2194397A1 (en) |
CH (1) | CH691808A5 (en) |
CZ (1) | CZ26997A3 (en) |
DE (1) | DE19680509T1 (en) |
DK (1) | DK10697A (en) |
ES (1) | ES2137886B1 (en) |
FI (1) | FI970393A (en) |
GB (1) | GB2304340B (en) |
GR (1) | GR1002702B (en) |
HU (1) | HUP9700274A3 (en) |
IE (1) | IE960405A1 (en) |
IL (1) | IL118477A0 (en) |
IT (1) | IT1290839B1 (en) |
LU (1) | LU90008B1 (en) |
MC (1) | MC2418A1 (en) |
MX (1) | MX9700379A (en) |
NL (1) | NL1003243C2 (en) |
NO (1) | NO307460B1 (en) |
NZ (1) | NZ308597A (en) |
PL (1) | PL318440A1 (en) |
SE (1) | SE510812C2 (en) |
SK (1) | SK13097A3 (en) |
TR (1) | TR199700020T1 (en) |
WO (1) | WO1996038416A1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994022834A1 (en) * | 1993-03-29 | 1994-10-13 | Zeneca Limited | Heterocyclic derivatives as platelet aggregation inhibitors |
WO1994022835A2 (en) * | 1993-03-29 | 1994-10-13 | Zeneca Limited | Heterocyclic compounds as platelet aggregation inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0100158A3 (en) * | 1982-07-28 | 1985-03-27 | The Upjohn Company | (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters |
GB8609630D0 (en) * | 1986-04-19 | 1986-05-21 | Pfizer Ltd | Anti-arrhythmia agents |
-
1996
- 1996-05-28 JP JP8536281A patent/JP2885941B2/en not_active Expired - Fee Related
- 1996-05-28 ES ES009750006A patent/ES2137886B1/en not_active Expired - Fee Related
- 1996-05-28 NZ NZ308597A patent/NZ308597A/en unknown
- 1996-05-28 GB GB9627127A patent/GB2304340B/en not_active Expired - Fee Related
- 1996-05-28 AT AT0900596A patent/AT406675B/en active
- 1996-05-28 TR TR97/00020T patent/TR199700020T1/en unknown
- 1996-05-28 SK SK130-97A patent/SK13097A3/en unknown
- 1996-05-28 HU HU9700274A patent/HUP9700274A3/en unknown
- 1996-05-28 GR GR960100176A patent/GR1002702B/en not_active IP Right Cessation
- 1996-05-28 DE DE19680509T patent/DE19680509T1/en not_active Withdrawn
- 1996-05-28 CZ CZ97269A patent/CZ26997A3/en unknown
- 1996-05-28 MX MX9700379A patent/MX9700379A/en unknown
- 1996-05-28 WO PCT/GB1996/001260 patent/WO1996038416A1/en not_active IP Right Cessation
- 1996-05-28 AU AU58272/96A patent/AU710105B2/en not_active Ceased
- 1996-05-28 BR BR9606409A patent/BR9606409A/en not_active Application Discontinuation
- 1996-05-28 CH CH00224/97A patent/CH691808A5/en not_active IP Right Cessation
- 1996-05-28 PL PL96318440A patent/PL318440A1/en unknown
- 1996-05-28 CA CA002194397A patent/CA2194397A1/en not_active Abandoned
- 1996-05-28 EP EP96919906A patent/EP0796247A1/en not_active Withdrawn
- 1996-05-28 KR KR1019970700532A patent/KR100245957B1/en not_active IP Right Cessation
- 1996-05-29 MC MC2347A patent/MC2418A1/en unknown
- 1996-05-30 IL IL11847796A patent/IL118477A0/en unknown
- 1996-05-31 BE BE9600491A patent/BE1009520A5/en not_active IP Right Cessation
- 1996-05-31 IE IE960405A patent/IE960405A1/en not_active IP Right Cessation
- 1996-05-31 NL NL1003243A patent/NL1003243C2/en not_active IP Right Cessation
- 1996-05-31 IT IT96MI001113A patent/IT1290839B1/en active IP Right Grant
-
1997
- 1997-01-22 LU LU90008A patent/LU90008B1/en active
- 1997-01-24 SE SE9700203A patent/SE510812C2/en not_active IP Right Cessation
- 1997-01-30 FI FI970393A patent/FI970393A/en unknown
- 1997-01-30 DK DK010697A patent/DK10697A/en not_active Application Discontinuation
- 1997-01-31 NO NO970437A patent/NO307460B1/en not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994022834A1 (en) * | 1993-03-29 | 1994-10-13 | Zeneca Limited | Heterocyclic derivatives as platelet aggregation inhibitors |
WO1994022835A2 (en) * | 1993-03-29 | 1994-10-13 | Zeneca Limited | Heterocyclic compounds as platelet aggregation inhibitors |
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
732E | Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977) | ||
PCNP | Patent ceased through non-payment of renewal fee |