SE9700203D0 - (-) - (3R) -3-methyl-4- (4- (4- (4-pyridyl) piperazin-1-yl) phenoxy) butyric acid as cellular adhesion inhibitor - Google Patents

(-) - (3R) -3-methyl-4- (4- (4- (4-pyridyl) piperazin-1-yl) phenoxy) butyric acid as cellular adhesion inhibitor

Info

Publication number
SE9700203D0
SE9700203D0 SE9700203A SE9700203A SE9700203D0 SE 9700203 D0 SE9700203 D0 SE 9700203D0 SE 9700203 A SE9700203 A SE 9700203A SE 9700203 A SE9700203 A SE 9700203A SE 9700203 D0 SE9700203 D0 SE 9700203D0
Authority
SE
Sweden
Prior art keywords
pyridyl
methyl
butyric acid
phenoxy
cellular adhesion
Prior art date
Application number
SE9700203A
Other languages
Swedish (sv)
Other versions
SE9700203L (en
SE510812C2 (en
Inventor
Stuart Dennett Mills
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/457,538 external-priority patent/US5652242A/en
Priority claimed from GBGB9518188.9A external-priority patent/GB9518188D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of SE9700203L publication Critical patent/SE9700203L/en
Publication of SE9700203D0 publication Critical patent/SE9700203D0/en
Publication of SE510812C2 publication Critical patent/SE510812C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

The novel optically active compound (-)-(3R)-3-methyl-4--4-[4-(4-pyridyl)-piperazine-1-yl]phenoxy butyric acid, and pharmaceutically-acceptable salts, esters, amides or solvates thereof. Processes for the preparation of the compound, pharmaceutical compositions containing the compound and its use to inhibit cellular adhesion, for example platelet aggregation.
SE9700203A 1995-06-01 1997-01-24 (-) - (3R) -3-methyl-4- (4- (4- (4-pyridyl) piperazin-1-yl) phenoxy) butyric acid as cellular adhesion inhibitor SE510812C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/457,538 US5652242A (en) 1993-03-29 1995-06-01 Heterocyclic derivatives
GBGB9518188.9A GB9518188D0 (en) 1995-09-07 1995-09-07 Optically active derivative
PCT/GB1996/001260 WO1996038416A1 (en) 1995-06-01 1996-05-28 (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor

Publications (3)

Publication Number Publication Date
SE9700203L SE9700203L (en) 1997-01-24
SE9700203D0 true SE9700203D0 (en) 1997-01-24
SE510812C2 SE510812C2 (en) 1999-06-28

Family

ID=26307696

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9700203A SE510812C2 (en) 1995-06-01 1997-01-24 (-) - (3R) -3-methyl-4- (4- (4- (4-pyridyl) piperazin-1-yl) phenoxy) butyric acid as cellular adhesion inhibitor

Country Status (31)

Country Link
EP (1) EP0796247A1 (en)
JP (1) JP2885941B2 (en)
KR (1) KR100245957B1 (en)
AT (1) AT406675B (en)
AU (1) AU710105B2 (en)
BE (1) BE1009520A5 (en)
BR (1) BR9606409A (en)
CA (1) CA2194397A1 (en)
CH (1) CH691808A5 (en)
CZ (1) CZ26997A3 (en)
DE (1) DE19680509T1 (en)
DK (1) DK10697A (en)
ES (1) ES2137886B1 (en)
FI (1) FI970393A0 (en)
GB (1) GB2304340B (en)
GR (1) GR1002702B (en)
HU (1) HUP9700274A3 (en)
IE (1) IE960405A1 (en)
IL (1) IL118477A0 (en)
IT (1) IT1290839B1 (en)
LU (1) LU90008B1 (en)
MC (1) MC2418A1 (en)
MX (1) MX9700379A (en)
NL (1) NL1003243C2 (en)
NO (1) NO307460B1 (en)
NZ (1) NZ308597A (en)
PL (1) PL318440A1 (en)
SE (1) SE510812C2 (en)
SK (1) SK13097A3 (en)
TR (1) TR199700020T1 (en)
WO (1) WO1996038416A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
IL109144A (en) * 1993-03-29 2000-02-29 Zeneca Ltd Glycoprotein IIB/IIIA inhibiting 4-pyridylamino heterocyclic derivatives process for their preparation and pharmaceutical compositions containing them
NZ262942A (en) * 1993-03-29 1997-07-27 Zeneca Ltd Pyridyl substituted piperazine and various other derivatives of azaheteroaryl substituted piperazines; pharmaceutical compositions

Also Published As

Publication number Publication date
CH691808A5 (en) 2001-10-31
AU710105B2 (en) 1999-09-16
IE960405A1 (en) 1996-12-11
AU5827296A (en) 1996-12-18
HU9700274D0 (en) 1997-04-28
AT406675B (en) 2000-07-25
EP0796247A1 (en) 1997-09-24
PL318440A1 (en) 1997-06-09
BE1009520A5 (en) 1997-04-01
GB2304340B (en) 1998-07-29
LU90008B1 (en) 1997-04-16
ITMI961113A1 (en) 1997-12-01
NL1003243C2 (en) 1996-12-04
FI970393A (en) 1997-01-30
NO307460B1 (en) 2000-04-10
MC2418A1 (en) 1997-05-23
KR100245957B1 (en) 2000-04-01
ATA900596A (en) 1999-12-15
NO970437L (en) 1997-02-20
DK10697A (en) 1997-04-01
JPH09512836A (en) 1997-12-22
SE9700203L (en) 1997-01-24
FI970393A0 (en) 1997-01-30
CA2194397A1 (en) 1996-12-05
HUP9700274A2 (en) 1999-06-28
IL118477A0 (en) 1996-09-12
ITMI961113A0 (en) 1996-05-31
SK13097A3 (en) 1997-08-06
KR970704689A (en) 1997-09-06
GB9627127D0 (en) 1997-02-19
GB2304340A (en) 1997-03-19
MX9700379A (en) 1997-04-30
WO1996038416A1 (en) 1996-12-05
ES2137886B1 (en) 2000-08-16
HUP9700274A3 (en) 2000-02-28
CZ26997A3 (en) 1997-08-13
SE510812C2 (en) 1999-06-28
BR9606409A (en) 1997-09-30
GR1002702B (en) 1997-05-22
DE19680509T1 (en) 1997-12-04
NO970437D0 (en) 1997-01-31
NZ308597A (en) 1998-11-25
JP2885941B2 (en) 1999-04-26
ES2137886A1 (en) 1999-12-16
TR199700020T1 (en) 1997-04-22
IT1290839B1 (en) 1998-12-14

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Legal Events

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