MC2418A1 - Process for the preparation of a (-) - (3R) -3-methyl-4- [4- [4- (4-pyridyl) piperazine-1-yl] phenoxy] butyric acid and of a pharmaceutical composition containing it - Google Patents

Process for the preparation of a (-) - (3R) -3-methyl-4- [4- [4- (4-pyridyl) piperazine-1-yl] phenoxy] butyric acid and of a pharmaceutical composition containing it

Info

Publication number
MC2418A1
MC2418A1 MC2347A MC2347A MC2418A1 MC 2418 A1 MC2418 A1 MC 2418A1 MC 2347 A MC2347 A MC 2347A MC 2347 A MC2347 A MC 2347A MC 2418 A1 MC2418 A1 MC 2418A1
Authority
MC
Monaco
Prior art keywords
piperazine
phenoxy
pyridyl
methyl
preparation
Prior art date
Application number
MC2347A
Other languages
French (fr)
Inventor
Stuart Dennett Mills
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/457,538 external-priority patent/US5652242A/en
Priority claimed from GBGB9518188.9A external-priority patent/GB9518188D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of MC2418A1 publication Critical patent/MC2418A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
MC2347A 1995-06-01 1996-05-29 Process for the preparation of a (-) - (3R) -3-methyl-4- [4- [4- (4-pyridyl) piperazine-1-yl] phenoxy] butyric acid and of a pharmaceutical composition containing it MC2418A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/457,538 US5652242A (en) 1993-03-29 1995-06-01 Heterocyclic derivatives
GBGB9518188.9A GB9518188D0 (en) 1995-09-07 1995-09-07 Optically active derivative

Publications (1)

Publication Number Publication Date
MC2418A1 true MC2418A1 (en) 1997-05-23

Family

ID=26307696

Family Applications (1)

Application Number Title Priority Date Filing Date
MC2347A MC2418A1 (en) 1995-06-01 1996-05-29 Process for the preparation of a (-) - (3R) -3-methyl-4- [4- [4- (4-pyridyl) piperazine-1-yl] phenoxy] butyric acid and of a pharmaceutical composition containing it

Country Status (31)

Country Link
EP (1) EP0796247A1 (en)
JP (1) JP2885941B2 (en)
KR (1) KR100245957B1 (en)
AT (1) AT406675B (en)
AU (1) AU710105B2 (en)
BE (1) BE1009520A5 (en)
BR (1) BR9606409A (en)
CA (1) CA2194397A1 (en)
CH (1) CH691808A5 (en)
CZ (1) CZ26997A3 (en)
DE (1) DE19680509T1 (en)
DK (1) DK10697A (en)
ES (1) ES2137886B1 (en)
FI (1) FI970393A0 (en)
GB (1) GB2304340B (en)
GR (1) GR1002702B (en)
HU (1) HUP9700274A3 (en)
IE (1) IE960405A1 (en)
IL (1) IL118477A0 (en)
IT (1) IT1290839B1 (en)
LU (1) LU90008B1 (en)
MC (1) MC2418A1 (en)
MX (1) MX9700379A (en)
NL (1) NL1003243C2 (en)
NO (1) NO307460B1 (en)
NZ (1) NZ308597A (en)
PL (1) PL318440A1 (en)
SE (1) SE510812C2 (en)
SK (1) SK13097A3 (en)
TR (1) TR199700020T1 (en)
WO (1) WO1996038416A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
CA2155307A1 (en) * 1993-03-29 1994-10-13 Michael Garth Wayne Heterocyclic compounds as platelet aggregation inhibitors
GB9406143D0 (en) * 1993-03-29 1994-05-18 Zeneca Ltd Heterocyclic derivatives

Also Published As

Publication number Publication date
SE9700203L (en) 1997-01-24
HU9700274D0 (en) 1997-04-28
KR100245957B1 (en) 2000-04-01
BE1009520A5 (en) 1997-04-01
IT1290839B1 (en) 1998-12-14
GB9627127D0 (en) 1997-02-19
NO970437D0 (en) 1997-01-31
AU5827296A (en) 1996-12-18
SK13097A3 (en) 1997-08-06
FI970393A (en) 1997-01-30
JPH09512836A (en) 1997-12-22
IL118477A0 (en) 1996-09-12
GB2304340A (en) 1997-03-19
ES2137886B1 (en) 2000-08-16
GB2304340B (en) 1998-07-29
MX9700379A (en) 1997-04-30
CA2194397A1 (en) 1996-12-05
ATA900596A (en) 1999-12-15
PL318440A1 (en) 1997-06-09
CH691808A5 (en) 2001-10-31
BR9606409A (en) 1997-09-30
JP2885941B2 (en) 1999-04-26
NZ308597A (en) 1998-11-25
NO307460B1 (en) 2000-04-10
KR970704689A (en) 1997-09-06
ITMI961113A0 (en) 1996-05-31
ES2137886A1 (en) 1999-12-16
SE9700203D0 (en) 1997-01-24
HUP9700274A2 (en) 1999-06-28
IE960405A1 (en) 1996-12-11
ITMI961113A1 (en) 1997-12-01
EP0796247A1 (en) 1997-09-24
DE19680509T1 (en) 1997-12-04
CZ26997A3 (en) 1997-08-13
AT406675B (en) 2000-07-25
LU90008B1 (en) 1997-04-16
NL1003243C2 (en) 1996-12-04
SE510812C2 (en) 1999-06-28
NO970437L (en) 1997-02-20
FI970393A0 (en) 1997-01-30
DK10697A (en) 1997-04-01
GR1002702B (en) 1997-05-22
AU710105B2 (en) 1999-09-16
TR199700020T1 (en) 1997-04-22
HUP9700274A3 (en) 2000-02-28
WO1996038416A1 (en) 1996-12-05

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