ES2137886A1 - Acido (-)-(3r)-3-metil-4-(4-(4-(4-piridil)piperazin-1-il)fenoxi) butirico como inhibidor de la adhesion celular. - Google Patents

Acido (-)-(3r)-3-metil-4-(4-(4-(4-piridil)piperazin-1-il)fenoxi) butirico como inhibidor de la adhesion celular.

Info

Publication number
ES2137886A1
ES2137886A1 ES009750006A ES9750006A ES2137886A1 ES 2137886 A1 ES2137886 A1 ES 2137886A1 ES 009750006 A ES009750006 A ES 009750006A ES 9750006 A ES9750006 A ES 9750006A ES 2137886 A1 ES2137886 A1 ES 2137886A1
Authority
ES
Spain
Prior art keywords
piperazin
phenoxy
pyridyl
methyl
butyric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009750006A
Other languages
English (en)
Other versions
ES2137886B1 (es
Inventor
Stuart Dennett Mills
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/457,538 external-priority patent/US5652242A/en
Priority claimed from GBGB9518188.9A external-priority patent/GB9518188D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of ES2137886A1 publication Critical patent/ES2137886A1/es
Application granted granted Critical
Publication of ES2137886B1 publication Critical patent/ES2137886B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Acido (-)-(3R) 3-metil-4-(4-(4-(4-piridil)piperazin-1-il)fenoxi) butírico ópticamente activo y sus sales, ésteres, amidas o solvatos farmacéuticamente aceptables. Procesos para la preparación del compuesto, composiciones farmacéuticas que contienen dicho compuesto y su uso para inhibir la adhesión celular, por ejemplo la agregación de plaquetas.
ES009750006A 1995-06-01 1996-05-28 Acido (-)-(3r)-3-metil-4-(4-(4-(4-piridil)piperazin-1-il)fenoxi) butirico como inhibidor de la adhesion celular. Expired - Fee Related ES2137886B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/457,538 US5652242A (en) 1993-03-29 1995-06-01 Heterocyclic derivatives
GBGB9518188.9A GB9518188D0 (en) 1995-09-07 1995-09-07 Optically active derivative

Publications (2)

Publication Number Publication Date
ES2137886A1 true ES2137886A1 (es) 1999-12-16
ES2137886B1 ES2137886B1 (es) 2000-08-16

Family

ID=26307696

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009750006A Expired - Fee Related ES2137886B1 (es) 1995-06-01 1996-05-28 Acido (-)-(3r)-3-metil-4-(4-(4-(4-piridil)piperazin-1-il)fenoxi) butirico como inhibidor de la adhesion celular.

Country Status (31)

Country Link
EP (1) EP0796247A1 (es)
JP (1) JP2885941B2 (es)
KR (1) KR100245957B1 (es)
AT (1) AT406675B (es)
AU (1) AU710105B2 (es)
BE (1) BE1009520A5 (es)
BR (1) BR9606409A (es)
CA (1) CA2194397A1 (es)
CH (1) CH691808A5 (es)
CZ (1) CZ26997A3 (es)
DE (1) DE19680509T1 (es)
DK (1) DK10697A (es)
ES (1) ES2137886B1 (es)
FI (1) FI970393A (es)
GB (1) GB2304340B (es)
GR (1) GR1002702B (es)
HU (1) HUP9700274A3 (es)
IE (1) IE960405A1 (es)
IL (1) IL118477A0 (es)
IT (1) IT1290839B1 (es)
LU (1) LU90008B1 (es)
MC (1) MC2418A1 (es)
MX (1) MX9700379A (es)
NL (1) NL1003243C2 (es)
NO (1) NO307460B1 (es)
NZ (1) NZ308597A (es)
PL (1) PL318440A1 (es)
SE (1) SE510812C2 (es)
SK (1) SK13097A3 (es)
TR (1) TR199700020T1 (es)
WO (1) WO1996038416A1 (es)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022834A1 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic derivatives as platelet aggregation inhibitors
WO1994022835A2 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022834A1 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic derivatives as platelet aggregation inhibitors
WO1994022835A2 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors

Also Published As

Publication number Publication date
NO307460B1 (no) 2000-04-10
SK13097A3 (en) 1997-08-06
AU710105B2 (en) 1999-09-16
SE9700203D0 (sv) 1997-01-24
IT1290839B1 (it) 1998-12-14
JPH09512836A (ja) 1997-12-22
PL318440A1 (en) 1997-06-09
CA2194397A1 (en) 1996-12-05
NO970437L (no) 1997-02-20
GB2304340B (en) 1998-07-29
NO970437D0 (no) 1997-01-31
AT406675B (de) 2000-07-25
NZ308597A (en) 1998-11-25
JP2885941B2 (ja) 1999-04-26
ITMI961113A0 (it) 1996-05-31
EP0796247A1 (en) 1997-09-24
GB2304340A (en) 1997-03-19
HUP9700274A3 (en) 2000-02-28
ES2137886B1 (es) 2000-08-16
ATA900596A (de) 1999-12-15
HU9700274D0 (en) 1997-04-28
NL1003243C2 (nl) 1996-12-04
GB9627127D0 (en) 1997-02-19
FI970393A0 (fi) 1997-01-30
GR1002702B (el) 1997-05-22
ITMI961113A1 (it) 1997-12-01
TR199700020T1 (tr) 1997-04-22
DK10697A (da) 1997-04-01
BR9606409A (pt) 1997-09-30
SE510812C2 (sv) 1999-06-28
LU90008B1 (fr) 1997-04-16
SE9700203L (sv) 1997-01-24
IL118477A0 (en) 1996-09-12
WO1996038416A1 (en) 1996-12-05
FI970393A (fi) 1997-01-30
AU5827296A (en) 1996-12-18
CH691808A5 (de) 2001-10-31
CZ26997A3 (en) 1997-08-13
KR100245957B1 (ko) 2000-04-01
IE960405A1 (en) 1996-12-11
HUP9700274A2 (hu) 1999-06-28
BE1009520A5 (fr) 1997-04-01
DE19680509T1 (de) 1997-12-04
MX9700379A (es) 1997-04-30
KR970704689A (ko) 1997-09-06
MC2418A1 (fr) 1997-05-23

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