WO1996038416A1 - (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor - Google Patents

(-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor Download PDF

Info

Publication number
WO1996038416A1
WO1996038416A1 PCT/GB1996/001260 GB9601260W WO9638416A1 WO 1996038416 A1 WO1996038416 A1 WO 1996038416A1 GB 9601260 W GB9601260 W GB 9601260W WO 9638416 A1 WO9638416 A1 WO 9638416A1
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutically
optically active
ester
active compound
amide
Prior art date
Application number
PCT/GB1996/001260
Other languages
English (en)
French (fr)
Inventor
Stuart Dennett Mills
Original Assignee
Zeneca Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/457,538 external-priority patent/US5652242A/en
Priority claimed from GBGB9518188.9A external-priority patent/GB9518188D0/en
Priority to GB9627127A priority Critical patent/GB2304340B/en
Priority to DE19680509T priority patent/DE19680509T1/de
Priority to JP8536281A priority patent/JP2885941B2/ja
Priority to NZ308597A priority patent/NZ308597A/en
Priority to SK130-97A priority patent/SK13097A3/sk
Priority to MX9700379A priority patent/MX9700379A/es
Priority to CZ97269A priority patent/CZ26997A3/cs
Priority to AU58272/96A priority patent/AU710105B2/en
Application filed by Zeneca Limited filed Critical Zeneca Limited
Priority to EP96919906A priority patent/EP0796247A1/en
Priority to KR1019970700532A priority patent/KR100245957B1/ko
Priority to BR9606409A priority patent/BR9606409A/pt
Priority to AT0900596A priority patent/AT406675B/de
Publication of WO1996038416A1 publication Critical patent/WO1996038416A1/en
Priority to LU90008A priority patent/LU90008B1/fr
Priority to SE9700203A priority patent/SE510812C2/sv
Priority to DK010697A priority patent/DK10697A/da
Priority to FI970393A priority patent/FI970393A/fi
Priority to NO970437A priority patent/NO307460B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
PCT/GB1996/001260 1995-06-01 1996-05-28 (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor WO1996038416A1 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
BR9606409A BR9606409A (pt) 1995-06-01 1996-05-28 Composto opticamente ativo composição farmacêutica processos para inibir agregação de plaqueta em um animal de sangue quente ligação de fibrinogênio a gpiib/iia em um animal de sangue quente e eventos trombóticos que acompanham agnina instável em animal de sangue quente e uso do composto opticamante ativo
AT0900596A AT406675B (de) 1995-06-01 1996-05-28 (-)-(3r)-3-methyl-4-(4-(4-(4-pyridyl) piperazin-1-yl)phenoxy)buttersäure als zellulärer adhäsionsinhibitor
EP96919906A EP0796247A1 (en) 1995-06-01 1996-05-28 (-)-(3r)-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl]phenoxy butyric acid as cellular adhesion inhibitor
JP8536281A JP2885941B2 (ja) 1995-06-01 1996-05-28 細胞付着抑制剤としての（−）−（３ｒ）−３−メチル−４−｛４−［４−（４−ピリジル）ピペラジン−１−イル］フェノキシ｝酪酸
NZ308597A NZ308597A (en) 1995-06-01 1996-05-28 (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid derivatives; medicaments; used as cellular adhesion inhibitor
SK130-97A SK13097A3 (en) 1995-06-01 1996-05-28 Optically active (-)-(3r)-3-methyl-4-{4-£4-(4-pyridyl)piperazin- -1-yl|phenoxy} butyric acid and its derivatives, preparation method thereof and their use
MX9700379A MX9700379A (es) 1995-06-01 1996-05-28 Acido(-)-(3r)-3-metil-4-(4-(4-(4-piridil)piperazin-1-il)-fenoxi)butirico como inhibidor de la adhesion celular.
CZ97269A CZ26997A3 (en) 1995-06-01 1996-05-28 Optically active (-)-(3r)-3.methyl-4-{4-£4-(4-pyridyl)piperazin-1-yl|phenoxy}butyric acid, derivatives thereof, process of their preparation and their use
AU58272/96A AU710105B2 (en) 1995-06-01 1996-05-28 (-)-(3R0-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy) butyric acid as cellular adhesion inhibitor
GB9627127A GB2304340B (en) 1995-06-01 1996-05-28 (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor
DE19680509T DE19680509T1 (de) 1995-06-01 1996-05-28 (-)-(3R)-3-Methyl-4-(4-(4-(4pyridyl)piperazin-1-yl)phenoxybuttersäure als Zellaadhäsionsinhibitor
KR1019970700532A KR100245957B1 (ko) 1995-06-01 1996-05-28 (-)-(3r)-3-메틸-4-(4-(4-(4-피리딜)피페라진-1-일)페녹시)부티르산 세포부착 저해제
LU90008A LU90008B1 (fr) 1995-06-01 1997-01-22 Acide(-)-(3R)-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)-phenoxy)butyrique a titre d'inhibiteur de l'adhésion cellulaire
SE9700203A SE510812C2 (sv) 1995-06-01 1997-01-24 (-)-(3R)-3-metyl-4-(4-(4-(4-pyridyl)piperazin-1- yl)fenoxi)smörsyra som cellulär adhesionsinhibitor
DK010697A DK10697A (da) 1995-06-01 1997-01-30 (-)-(3R)-3-methyl-4-(4-(4-(4-pyridyl)Piperazinl-yl)phenoxy)smørsyre som cellulær adhæsionsinhibitor.
FI970393A FI970393A (fi) 1995-06-01 1997-01-30 (-)-(3R)-3-metyyli-4-(4-(4-(4-pyridyyli)piperatsin-1-yyli)fenoksi)voihappo soluadheesioinhibiittoreina
NO970437A NO307460B1 (no) 1995-06-01 1997-01-31 Optiske aktive forbindelser, fremgangsmõte for fremstilling derav, farmasøytisk blanding og anvendelse derav

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/457,538 US5652242A (en) 1993-03-29 1995-06-01 Heterocyclic derivatives
US08/457,538 1995-06-01
GBGB9518188.9A GB9518188D0 (en) 1995-09-07 1995-09-07 Optically active derivative
GB9518188.9 1995-09-07

Publications (1)

Publication Number Publication Date
WO1996038416A1 true WO1996038416A1 (en) 1996-12-05

Family

ID=26307696

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/001260 WO1996038416A1 (en) 1995-06-01 1996-05-28 (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor

Country Status (31)

Country Link
EP (1) EP0796247A1 (es)
JP (1) JP2885941B2 (es)
KR (1) KR100245957B1 (es)
AT (1) AT406675B (es)
AU (1) AU710105B2 (es)
BE (1) BE1009520A5 (es)
BR (1) BR9606409A (es)
CA (1) CA2194397A1 (es)
CH (1) CH691808A5 (es)
CZ (1) CZ26997A3 (es)
DE (1) DE19680509T1 (es)
DK (1) DK10697A (es)
ES (1) ES2137886B1 (es)
FI (1) FI970393A (es)
GB (1) GB2304340B (es)
GR (1) GR1002702B (es)
HU (1) HUP9700274A3 (es)
IE (1) IE960405A1 (es)
IL (1) IL118477A0 (es)
IT (1) IT1290839B1 (es)
LU (1) LU90008B1 (es)
MC (1) MC2418A1 (es)
MX (1) MX9700379A (es)
NL (1) NL1003243C2 (es)
NO (1) NO307460B1 (es)
NZ (1) NZ308597A (es)
PL (1) PL318440A1 (es)
SE (1) SE510812C2 (es)
SK (1) SK13097A3 (es)
TR (1) TR199700020T1 (es)
WO (1) WO1996038416A1 (es)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022834A1 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic derivatives as platelet aggregation inhibitors
WO1994022835A2 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022834A1 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic derivatives as platelet aggregation inhibitors
WO1994022835A2 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors

Also Published As

Publication number Publication date
TR199700020T1 (tr) 1997-04-22
AU710105B2 (en) 1999-09-16
ES2137886B1 (es) 2000-08-16
NL1003243C2 (nl) 1996-12-04
FI970393A0 (fi) 1997-01-30
ES2137886A1 (es) 1999-12-16
NZ308597A (en) 1998-11-25
HU9700274D0 (en) 1997-04-28
BE1009520A5 (fr) 1997-04-01
CH691808A5 (de) 2001-10-31
MX9700379A (es) 1997-04-30
AT406675B (de) 2000-07-25
EP0796247A1 (en) 1997-09-24
SE9700203L (sv) 1997-01-24
ATA900596A (de) 1999-12-15
KR100245957B1 (ko) 2000-04-01
NO970437D0 (no) 1997-01-31
HUP9700274A3 (en) 2000-02-28
IT1290839B1 (it) 1998-12-14
GB2304340B (en) 1998-07-29
CZ26997A3 (en) 1997-08-13
GB9627127D0 (en) 1997-02-19
BR9606409A (pt) 1997-09-30
SK13097A3 (en) 1997-08-06
AU5827296A (en) 1996-12-18
NO970437L (no) 1997-02-20
HUP9700274A2 (hu) 1999-06-28
IE960405A1 (en) 1996-12-11
IL118477A0 (en) 1996-09-12
JP2885941B2 (ja) 1999-04-26
ITMI961113A1 (it) 1997-12-01
JPH09512836A (ja) 1997-12-22
PL318440A1 (en) 1997-06-09
GB2304340A (en) 1997-03-19
MC2418A1 (fr) 1997-05-23
GR1002702B (el) 1997-05-22
DK10697A (da) 1997-04-01
DE19680509T1 (de) 1997-12-04
SE9700203D0 (sv) 1997-01-24
CA2194397A1 (en) 1996-12-05
NO307460B1 (no) 2000-04-10
SE510812C2 (sv) 1999-06-28
LU90008B1 (fr) 1997-04-16
FI970393A (fi) 1997-01-30
ITMI961113A0 (it) 1996-05-31
KR970704689A (ko) 1997-09-06

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