AU627220B2 - Improvements in or relating to organic compounds - Google Patents
Improvements in or relating to organic compounds Download PDFInfo
- Publication number
- AU627220B2 AU627220B2 AU41400/89A AU4140089A AU627220B2 AU 627220 B2 AU627220 B2 AU 627220B2 AU 41400/89 A AU41400/89 A AU 41400/89A AU 4140089 A AU4140089 A AU 4140089A AU 627220 B2 AU627220 B2 AU 627220B2
- Authority
- AU
- Australia
- Prior art keywords
- composition according
- cyclosporin
- composition
- compositions
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8821754 | 1988-09-16 | ||
GB888821754A GB8821754D0 (en) | 1988-09-16 | 1988-09-16 | Improvements in/relating to organic compounds |
GB8902903 | 1989-02-09 | ||
GB898902903A GB8902903D0 (en) | 1989-02-09 | 1989-02-09 | Improvements in or relating to organic compounds |
GB8902900 | 1989-02-09 | ||
GB898902900A GB8902900D0 (en) | 1989-02-09 | 1989-02-09 | Improvements in or relating to organic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
AU4140089A AU4140089A (en) | 1990-03-22 |
AU627220B2 true AU627220B2 (en) | 1992-08-20 |
Family
ID=27264085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU41400/89A Expired AU627220B2 (en) | 1988-09-16 | 1989-09-14 | Improvements in or relating to organic compounds |
Country Status (32)
Country | Link |
---|---|
US (7) | US5741512A (hu) |
JP (1) | JPH0725690B2 (hu) |
KR (3) | KR0148748B1 (hu) |
AT (1) | AT403435B (hu) |
AU (1) | AU627220B2 (hu) |
BE (1) | BE1003105A5 (hu) |
BG (1) | BG60525B2 (hu) |
CA (1) | CA1332150C (hu) |
CH (1) | CH679118A5 (hu) |
DE (1) | DE3930928C2 (hu) |
DK (1) | DK171433B1 (hu) |
ES (1) | ES2020738A6 (hu) |
FI (1) | FI98046C (hu) |
FR (1) | FR2636534B1 (hu) |
GB (1) | GB2222770B (hu) |
GR (1) | GR1000456B (hu) |
HK (1) | HK86593A (hu) |
HU (1) | HU211685A9 (hu) |
ID (1) | ID17863A (hu) |
IE (1) | IE60764B1 (hu) |
IL (1) | IL91642A (hu) |
IT (1) | IT1232243B (hu) |
LU (1) | LU87586A1 (hu) |
LV (1) | LV5749B4 (hu) |
MY (1) | MY107381A (hu) |
NL (1) | NL194781C (hu) |
NO (1) | NO180362C (hu) |
NZ (1) | NZ230660A (hu) |
PH (1) | PH31059A (hu) |
PT (1) | PT91731B (hu) |
SE (2) | SE8903042L (hu) |
SG (1) | SG50793G (hu) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU659460B2 (en) * | 1991-06-27 | 1995-05-18 | Novartis Ag | Improvements in or relating to organic compounds |
US8535713B2 (en) | 2007-04-04 | 2013-09-17 | Sigmoid Pharma Limited | Pharmaceutical cyclosporin compositions |
US8951570B2 (en) | 2007-04-26 | 2015-02-10 | Sigmoid Pharma Limited | Manufacture of multiple minicapsules |
US9220681B2 (en) | 2012-07-05 | 2015-12-29 | Sigmoid Pharma Limited | Formulations |
US9278070B2 (en) | 2009-05-18 | 2016-03-08 | Sigmoid Pharma Limited | Composition comprising oil drops |
US9821024B2 (en) | 2010-11-25 | 2017-11-21 | Sigmoid Pharma Limited | Immunomodulatory compositions |
US9878036B2 (en) | 2009-08-12 | 2018-01-30 | Sigmoid Pharma Limited | Immunomodulatory compositions comprising a polymer matrix and an oil phase |
US10434138B2 (en) | 2013-11-08 | 2019-10-08 | Sublimity Therapeutics Limited | Formulations |
Families Citing this family (174)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5639724A (en) * | 1984-07-24 | 1997-06-17 | Sandoz Ltd. | Cyclosporin galenic forms |
US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
GR1000466B (el) * | 1989-01-28 | 1992-07-30 | Sandoz Ag | Μεθοδος παρασκευης νεων φαρμακευτικων μορφων κυκλοσπορινης. |
BE1003009A5 (fr) * | 1989-02-09 | 1991-10-22 | Sandoz Sa | Nouvelles compositions pharmaceutiques a base de cyclosporines. |
US7081445B2 (en) * | 1989-02-20 | 2006-07-25 | Novartis Ag | Cyclosporin galenic forms |
US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
GB8916901D0 (en) | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
HU208491B (en) * | 1990-11-27 | 1993-11-29 | Gyogyszerkutato Intezet | Process for producing oral pharmaceutical composition containing cyclosporin |
DE69229779T2 (de) * | 1991-04-19 | 1999-12-23 | Lds Technologies, Inc. | Konvertierbare mikroemulsionsverbindungen |
US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
AU688920B2 (en) * | 1991-06-27 | 1998-03-19 | Novartis Ag | Transesterified corn oil products |
IL102236A0 (en) * | 1991-06-27 | 1993-01-14 | Ltt Inst Co Ltd | Topical preparations containing cyclosporin |
GB9208712D0 (en) * | 1992-04-22 | 1992-06-10 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporin derivates |
WO1993023010A1 (en) * | 1992-05-13 | 1993-11-25 | Sandoz Ltd. | Ophthalmic compositions containing a cyclosporin |
ES2168271T3 (es) * | 1992-09-25 | 2002-06-16 | Novartis Ag | Composiciones farmaceuticas que contienen ciclosporinas. |
PT697881E (pt) † | 1993-04-20 | 2002-10-31 | Novartis Ag | Novas composicoes farmaceuticas contendo ciclosporina para administracao oral |
NZ247516A (en) * | 1993-04-28 | 1995-02-24 | Bernard Charles Sherman | Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant |
GB2278780B (en) * | 1993-05-27 | 1998-10-14 | Sandoz Ltd | Macrolide formulations |
CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
DE4447972B4 (de) * | 1993-05-27 | 2007-12-27 | Novartis Ag | Galenische Formulierungen |
AT408520B (de) * | 1993-05-27 | 2001-12-27 | Novartis Erfind Verwalt Gmbh | Galenische formulierungen |
DE4322826A1 (de) * | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmazeutisches Präparat |
GB2281697A (en) * | 1993-09-14 | 1995-03-15 | Euro Celtique Sa | Laxative compositions in capsules |
DK1033128T4 (da) * | 1993-09-28 | 2012-03-19 | Scherer Gmbh R P | Blød gelatinekapselfremstilling |
GB2315216B (en) * | 1993-10-05 | 1998-10-14 | Ciba Geigy Ag | Microemulsion preconcentrates comprising FK506 or 33-epi-chloro-33-desoxy-ascomycin |
DE4340781C3 (de) * | 1993-11-30 | 2000-01-27 | Novartis Ag | Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung |
KR0146671B1 (ko) * | 1994-02-25 | 1998-08-17 | 김충환 | 사이클로스포린-함유 분말 조성물 |
GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
US5447729A (en) * | 1994-04-07 | 1995-09-05 | Pharmavene, Inc. | Multilamellar drug delivery systems |
US5474979A (en) * | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
FI100692B (fi) * | 1994-05-24 | 1998-02-13 | Leiras Oy | Menetelmä farmaseuttisten koostumusten valmistamiseksi, jolloin koostu mukset pohjautuvat mikroemulsiogeeleihin sekä uusia mikroemulsioihin p ohjautuvia geelejä |
GB2308545B (en) * | 1994-10-26 | 1999-06-02 | Novartis Ag | Pharmaceutical microemulsion preconcentrates |
IL115742A (en) * | 1994-10-26 | 2000-06-01 | Novartis Ag | Pharmaceutical compositions comprising a difficultly soluble active agent a hydrophilic phase a lipophilic phase and a surfactant |
EP0789580B1 (de) | 1994-11-03 | 2002-06-05 | Novartis AG | Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung |
US5603951A (en) * | 1994-11-09 | 1997-02-18 | Hanmi Pharm. Ind. Co., Ltd. | Cyclosporin-containing soft capsule compositions |
HU215966B (hu) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
KR0167613B1 (ko) * | 1994-12-28 | 1999-01-15 | 한스 루돌프 하우스, 니콜 케르커 | 사이클로스포린-함유 연질캅셀제 조성물 |
WO1996036316A1 (en) * | 1995-05-19 | 1996-11-21 | Abbott Laboratories | Self-emulsifying formulations of lipophilic drugs |
US6696413B2 (en) * | 1995-06-16 | 2004-02-24 | Hexal Ag | Pharmaceutical preparation with cyclosporin A |
EP0760237A1 (en) * | 1995-08-30 | 1997-03-05 | Cipla Limited | Oil-in-water microemulsions |
DE19544507B4 (de) | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin enthaltende Präparate |
NZ280689A (en) * | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
CZ288631B6 (cs) * | 1996-01-18 | 2001-08-15 | Galena, A. S. | Léčivé přípravky s obsahem cyklosporinu |
GB9601120D0 (en) * | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
US6245349B1 (en) * | 1996-02-23 | 2001-06-12 | éLAN CORPORATION PLC | Drug delivery compositions suitable for intravenous injection |
KR970064620A (ko) * | 1996-03-05 | 1997-10-13 | 임성기 | 사이클로스포린-함유 외용약제 조성물 |
SE511313C2 (sv) | 1997-01-13 | 1999-09-06 | Gs Dev Ab | Komposition med reglerad frisättning innefattande fettsyraester av diacylglycerol |
ES2229473T3 (es) | 1997-01-30 | 2005-04-16 | Novartis Ag | Composiciones farmaceuticas sin aceite que contienen ciclosporina a. |
US6426078B1 (en) | 1997-03-17 | 2002-07-30 | Roche Vitamins Inc. | Oil in water microemulsion |
ATE215370T1 (de) * | 1997-07-29 | 2002-04-15 | Upjohn Co | Selbstemulgierende formulierung enthaltend lipophile verbindungen |
DE69808463T2 (de) | 1997-07-29 | 2003-06-26 | Pharmacia & Upjohn Co., Kalamazoo | Selbstemulgierende formulierung enthaltend saure lipophile verbindungen |
US6008191A (en) * | 1997-09-08 | 1999-12-28 | Panacea Biotec Limited | Pharmaceutical compositions containing cyclosporin |
US6187747B1 (en) | 1997-09-08 | 2001-02-13 | Panacea Biotech Limited | Pharmaceutical composition comprising cyclosporin |
US6346511B1 (en) | 1997-09-08 | 2002-02-12 | Panacea Biotec Limited | Pharmaceutical composition comprising cyclosporin |
US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
ATE314388T1 (de) | 1997-10-08 | 2006-01-15 | Isotechnika Inc | Deuterierte und undeuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agentien |
US6063762A (en) * | 1997-12-05 | 2000-05-16 | Chong Kun Dang Corp. | Cyclosporin-containing microemulsion preconcentrate composition |
WO1999029335A1 (en) * | 1997-12-05 | 1999-06-17 | Chong Kun Dang Corp. | Pharmaceutical composition containing cyclosporin |
GB2380673B (en) * | 1998-03-06 | 2003-05-28 | Novartis Ag | Emulsion preconcentrates containing cyclosporin or a macrolide |
ID25908A (id) * | 1998-03-06 | 2000-11-09 | Novartis Ag | Prakonsentrat-prakonsentrat emulsi yang mengandung siklosporin atau makrolida |
EP1091975B1 (fr) | 1998-07-01 | 2005-12-14 | Debiopharm S.A. | Nouvelle cyclosporine ayant un profil d'activite ameliore |
EP0977180B1 (en) * | 1998-07-30 | 2005-02-09 | STMicroelectronics S.r.l. | Method for assembling an actuator device for a hard disc device, comprising a read/write transducer, a microactuator and a suspension and the actuator device thus obtained |
PT982035E (pt) * | 1998-08-18 | 2004-08-31 | Panacea Biotec Ltd | Composicao de ciclosporina compreendendo um veiculo hidrofilo |
SE9804192D0 (sv) * | 1998-12-03 | 1998-12-03 | Scotia Lipidteknik Ab | New formulation |
GB2344520A (en) * | 1998-12-08 | 2000-06-14 | Phares Pharm Res Nv | Pharmaceutical carriers comprising lipids and polymers |
PL348193A1 (en) | 1998-12-11 | 2002-05-06 | Pharmasolutions | Self-emulsifying compositions for drugs poorly soluble in water |
NZ512599A (en) * | 1998-12-30 | 2003-10-31 | Dexcel Ltd | Formulation for cyclosporin administration featuring a hydrophilic solvent and a surfactant with a HLB of less than 5 |
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US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US6057289A (en) * | 1999-04-30 | 2000-05-02 | Pharmasolutions, Inc. | Pharmaceutical composition comprising cyclosporin in association with a carrier in a self-emulsifying drug delivery system |
GB9912476D0 (en) | 1999-05-28 | 1999-07-28 | Novartis Ag | Organic compounds |
DE19925001A1 (de) * | 1999-05-31 | 2000-12-07 | Pharma Concepts Gmbh & Co Kg | Flüssiges Konzentrat |
US20030236236A1 (en) * | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
GB2355656B (en) * | 1999-08-17 | 2004-04-07 | Galena As | Pharmaceutical compositions for oral and topical administration |
JP2001122779A (ja) * | 1999-10-26 | 2001-05-08 | Toyo Capsule Kk | 経口投与用シクロスポリン含有ミクロエマルジョン濃縮液 |
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US7919113B2 (en) * | 1999-12-30 | 2011-04-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Dispersible concentrate lipospheres for delivery of active agents |
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DE10029404B4 (de) * | 2000-06-15 | 2009-10-29 | Jagotec Ag | Arzneiformulierung enthaltend Ciclosporin und deren Verwendung |
US6623765B1 (en) * | 2000-08-01 | 2003-09-23 | University Of Florida, Research Foundation, Incorporated | Microemulsion and micelle systems for solubilizing drugs |
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JP2005506990A (ja) * | 2001-10-19 | 2005-03-10 | アイソテクニカ インコーポレーテッド | 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート |
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KR100525234B1 (ko) * | 2003-02-19 | 2005-10-28 | 한국유나이티드제약 주식회사 | 사이클로스포린 함유 연질캅셀제 및 그 제조방법 |
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US20060003002A1 (en) * | 2003-11-03 | 2006-01-05 | Lipocine, Inc. | Pharmaceutical compositions with synchronized solubilizer release |
CA2546347A1 (en) | 2003-11-21 | 2005-06-09 | Combinatorx, Incorporated | Methods and reagents for the treatment of inflammatory disorders |
PE20050596A1 (es) * | 2003-12-19 | 2005-10-18 | Novartis Ag | Microemulsion que comprende un inhibidor renina |
IL159729A0 (en) * | 2004-01-06 | 2004-06-20 | Doron I Friedman | Non-aqueous composition for oral delivery of insoluble bioactive agents |
BRPI0506764A (pt) * | 2004-01-09 | 2007-05-22 | Wyeth Corp | microemulsões para composições farmacêuticas |
US20080249147A1 (en) * | 2004-03-24 | 2008-10-09 | Takeda Pharmaceutical Company Limited | Emulsion-Stabilized Preparation |
JPWO2005089716A1 (ja) * | 2004-03-24 | 2008-01-31 | 武田薬品工業株式会社 | 高含量化製剤 |
CN101065139A (zh) * | 2004-10-09 | 2007-10-31 | 扶瑞药业股份有限公司 | 眼用药剂递送系统 |
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