AU617986B2 - Peptide derivatives - Google Patents

Peptide derivatives Download PDF

Info

Publication number
AU617986B2
AU617986B2 AU79564/87A AU7956487A AU617986B2 AU 617986 B2 AU617986 B2 AU 617986B2 AU 79564/87 A AU79564/87 A AU 79564/87A AU 7956487 A AU7956487 A AU 7956487A AU 617986 B2 AU617986 B2 AU 617986B2
Authority
AU
Australia
Prior art keywords
hydrogen
formula
residue
acid
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU79564/87A
Other languages
English (en)
Other versions
AU7956487A (en
Inventor
Rainer Albert
Wilfried Bauer
Francois Cardinaux
Monika Mergler
Janos Pless
Walter Prikoszovich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of AU7956487A publication Critical patent/AU7956487A/en
Application granted granted Critical
Publication of AU617986B2 publication Critical patent/AU617986B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU79564/87A 1986-10-13 1987-10-12 Peptide derivatives Ceased AU617986B2 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DE3634826 1986-10-13
DE3634797 1986-10-13
DE3634825 1986-10-13
DE3634826 1986-10-13
DE3634797 1986-10-13
DE3634825 1986-10-13
DE3712626 1987-04-14
DE3712626 1987-04-14
CH315387 1987-08-17
CH3153/87 1987-08-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU80150/91A Division AU634664B2 (en) 1986-10-13 1991-07-03 Solid phase synthesis of peptide alcohols

Publications (2)

Publication Number Publication Date
AU7956487A AU7956487A (en) 1988-04-14
AU617986B2 true AU617986B2 (en) 1991-12-12

Family

ID=27509117

Family Applications (2)

Application Number Title Priority Date Filing Date
AU79564/87A Ceased AU617986B2 (en) 1986-10-13 1987-10-12 Peptide derivatives
AU80150/91A Expired AU634664B2 (en) 1986-10-13 1991-07-03 Solid phase synthesis of peptide alcohols

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU80150/91A Expired AU634664B2 (en) 1986-10-13 1991-07-03 Solid phase synthesis of peptide alcohols

Country Status (23)

Country Link
US (1) US5656721A (enExample)
JP (2) JPH0645639B2 (enExample)
KR (1) KR960016861B1 (enExample)
AU (2) AU617986B2 (enExample)
BE (1) BE1003752A4 (enExample)
CA (1) CA1340985C (enExample)
CH (2) CH682632A5 (enExample)
DE (1) DE3790635T1 (enExample)
DK (1) DK174337B1 (enExample)
ES (1) ES2007418A6 (enExample)
FI (1) FI874495L (enExample)
FR (1) FR2609991A1 (enExample)
GB (2) GB2199829B (enExample)
GR (1) GR871567B (enExample)
HU (3) HU906341D0 (enExample)
IE (1) IE912442A1 (enExample)
LU (1) LU87014A1 (enExample)
NL (1) NL194729C (enExample)
NZ (1) NZ222133A (enExample)
PL (1) PL157156B1 (enExample)
PT (1) PT85904B (enExample)
SE (2) SE8703938L (enExample)
WO (1) WO1988002756A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623385B2 (en) * 1988-04-08 1992-05-14 Sandoz Ltd. Improvements in or relating to organic compounds

Families Citing this family (62)

* Cited by examiner, † Cited by third party
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HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
EP0397779A1 (en) * 1988-02-01 1990-11-22 The Upjohn Company Renin inhibiting peptides with polar end groups
DE3910667A1 (de) * 1988-04-11 1989-10-19 Sandoz Ag Peptidderivate
GB8813339D0 (en) * 1988-06-06 1988-07-13 Sandoz Ltd Improvements in/relating to organic compounds
BE1003762A3 (fr) * 1988-11-11 1992-06-09 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives.
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
US5776894A (en) * 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
IT1229514B (it) * 1989-01-30 1991-09-03 Farmhispania S A A Montme Glicoconiugati anfifilici sintetici per impiego neurologico.
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
IT1260156B (it) * 1992-08-03 1996-03-28 Fidia Spa Derivati dell'acido neuraminico
TW263437B (enExample) * 1992-09-24 1995-11-21 Takeda Pharm Industry Co Ltd
US5710244A (en) * 1992-12-31 1998-01-20 Labroo; Virender M. Derivatized calcitonins
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
HU224350B1 (hu) * 1993-08-09 2005-08-29 Société de Conseils de Recherches et d'ApplicationScientifiques, S.A.S. Á Gyógyhatású peptidszármazékok
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
JP3896430B2 (ja) * 1996-07-15 2007-03-22 アークレイ株式会社 糖化アミノ化合物の製造方法
IL119029A0 (en) * 1996-08-07 1996-11-14 Yeda Res & Dev Long-acting drugs and pharamaceutical compositions comprising them
EP0981364B1 (en) 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Method and compositions for treating hyperlipidemia
CA2290592A1 (en) 1997-05-13 1998-11-19 Michael Anthony Cawthorne Somatostatin and somatostatin agonists for decreasing body weight
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
EP1053001B1 (en) * 1998-02-13 2010-12-15 Amylin Pharmaceuticals, Inc. Novel mixed amylin activity compounds
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US20050037490A1 (en) * 1999-10-29 2005-02-17 Lawrence Rosenberg Medium for preparing dedifferentiated cells
JP5398945B2 (ja) * 2001-04-23 2014-01-29 マリンクロッド エルエルシー ＴｃおよびＲｅ標識放射活性グリコシル化オクトレオチド誘導体
NZ530007A (en) 2001-06-08 2006-02-24 Sod Conseils Rech Applic Somatostatin-dopamine chimeric analogues that retain both somatostatin and dopamine activity in vivo and display enhanced biological activity
JP4615221B2 (ja) * 2002-02-27 2011-01-19 フェリング ベスローテン フェンノートシャップ ヘプタペプチドオキシトシンアナログを製造するための中間体及び方法
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2007025286A2 (en) * 2005-08-26 2007-03-01 The Board Of Trustees Of The Leland Stanford Junior University Therapy procedure for drug delivery for trigeminal pain
ES2383303T3 (es) 2005-11-10 2012-06-20 Chemi S.P.A. Formulaciones de inhibidores de la liberación prolongada de la hormona del crecimiento análogos de la somatostatina
WO2008011168A2 (en) * 2006-07-21 2008-01-24 Amgen Inc. Glycosylated peptide antagonists of the bradykinin b1 receptor
PL2118123T3 (pl) 2007-01-31 2016-06-30 Dana Farber Cancer Inst Inc Stabilizowane peptydy p53 i ich zastosowania
JP5631201B2 (ja) 2007-03-28 2014-11-26 プレジデント アンド フェローズ オブ ハーバード カレッジ ステッチングされたポリペプチド
CA2700587A1 (en) 2007-09-25 2009-04-02 Glycom A/S Glycoproteins and glycosylated cells and a method for the preparation of the same
JP5660898B2 (ja) * 2007-11-09 2015-01-28 ユニバーシティ オブ テネシー リサーチ ファウンデーション 経口投与用の抗炎症性キナ酸誘導体
EP2310028B1 (en) 2008-06-12 2016-11-16 Ipsen Bioinnovation Limited Fusion proteins for use in the treatment of acromegaly
WO2009150470A2 (en) 2008-06-12 2009-12-17 Syntaxin Limited Suppression of cancers
WO2010089757A2 (en) * 2008-11-07 2010-08-12 Usv Limited An improved process for synthesis of cyclic octapeptide
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
KR102104762B1 (ko) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
JP6211418B2 (ja) 2011-09-04 2017-10-11 株式会社糖鎖工学研究所 糖鎖付加ポリペプチドおよび当該ポリペプチドを含む医薬組成物
CA2847334C (en) 2011-09-04 2020-09-01 Glytech, Inc. Glycosylated polypeptide and drug composition containing said polypeptide
EP2768518A4 (en) 2011-10-18 2015-05-27 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
RU2642299C2 (ru) 2012-02-15 2018-01-24 Эйлерон Терапьютикс, Инк. P53 пептидомиметические макроциклы
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
EP3007704B1 (en) 2013-06-13 2021-01-06 Antisense Therapeutics Ltd Combination therapy for acromegaly
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US11389473B2 (en) 2015-01-07 2022-07-19 Tonix Pharmaceuticals Holding Corp. Magnesium-containing oxytocin formulations and methods of use
JP2018516844A (ja) 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用
MX2018012351A (es) 2016-04-12 2019-02-07 Trigemina Inc Formulaciones de oxitocina que contienen magnesio y metodos de uso.
EP3713545A1 (en) 2017-11-22 2020-09-30 Dauntless 1, Inc. Therapeutic compound formulations
US20200353419A1 (en) 2017-11-22 2020-11-12 Dauntless 1, Inc. Membrane emulsification device for microsphere creation
WO2020005842A1 (en) 2018-06-25 2020-01-02 Dauntless 2, Inc. Membrane emulsification device with impeller for microsphere creation
EP3956343A1 (en) 2019-04-16 2022-02-23 Bachem Holding AG Manufacture of disulfide bonded peptides
EP4135698A4 (en) 2020-04-17 2024-08-14 The Trustees of Indiana University SMALL MOLECULE ANTIVIRAL DRUG TREATMENT FOR HUMAN PAPILLOMAVIRUS INFECTIONS
US20230399373A1 (en) * 2020-10-22 2023-12-14 The Trustees Of Indiana University Molecular designs of glucose-responsive and glucose-cleavable insulin analogues
EP4727553A2 (en) 2023-06-13 2026-04-22 The Trustees of Indiana University Small molecule antiviral drug treatment for human papillomavirus infections
WO2025229200A1 (en) 2024-05-03 2025-11-06 Bachem Holding Ag Manufacture of disulfide bonded peptides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5376886A (en) * 1985-02-20 1986-08-28 Ciba-Geigy Ag Acylated hexose derivatives and processes for the manufacture thereof
AU6778487A (en) * 1985-12-20 1987-07-15 Astra Lakemedel Aktiebolag New 8-substituted derivatives of an anhydrooctonic acid, methods for their preparation, pharmaceutical preparations containing these and intermediates
AU1840988A (en) * 1987-06-29 1989-01-05 Sandoz Ltd. Improvements in or relating to organic compounds

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254023A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Synthesis of peptide alcohols by the solid phase method
US4280953A (en) * 1979-11-08 1981-07-28 The Salk Institute For Biological Studies Glycosylated analogs of somatostatin
DE3062075D1 (en) * 1979-11-27 1983-03-24 Sandoz Ag Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use
FR2522967B1 (fr) * 1982-03-15 1986-03-07 Anvar Conjugues d'haptenes et de muramyl-peptides, doues d'activite immunogene et compositions les contenant
US4483792A (en) * 1982-11-17 1984-11-20 Kim Wan S Glycosylated insulin derivatives
US4444683A (en) * 1982-11-17 1984-04-24 University Of Utah Glycosylated insulin derivatives
FR2546163B1 (fr) * 1983-05-16 1987-10-09 Centre Nat Rech Scient Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
FR2548673B1 (fr) * 1983-07-05 1985-10-04 Essilor Int Polymeres supports de produits actifs relargables et leur procede de preparation
LU85269A1 (fr) * 1984-03-26 1985-10-14 Techland S A Composes nouveaux de somatostatine,procede pour leur synthese,preparation a usage veterinaire contenant lesdits composes et procede pour le traitement d'animaux
US4564998A (en) * 1984-10-19 1986-01-21 Westinghouse Electric Corp. Coil winding methods and apparatus
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin
JPS61264260A (ja) * 1985-05-17 1986-11-22 Rikagaku Kenkyusho アルデヒド化多孔性高分子材料によるタンパク質の除去方法
CA1337041C (en) * 1985-10-09 1995-09-19 Brett Alan Evans Granular detergent compositions having improved solubility
JPS63165411A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製法
JPS63165410A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製造方法
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
US4859736A (en) * 1987-03-30 1989-08-22 Ciba-Geigy Corporation Synthetic polystyrene resin and its use in solid phase peptide synthesis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5376886A (en) * 1985-02-20 1986-08-28 Ciba-Geigy Ag Acylated hexose derivatives and processes for the manufacture thereof
AU6778487A (en) * 1985-12-20 1987-07-15 Astra Lakemedel Aktiebolag New 8-substituted derivatives of an anhydrooctonic acid, methods for their preparation, pharmaceutical preparations containing these and intermediates
AU1840988A (en) * 1987-06-29 1989-01-05 Sandoz Ltd. Improvements in or relating to organic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623385B2 (en) * 1988-04-08 1992-05-14 Sandoz Ltd. Improvements in or relating to organic compounds

Also Published As

Publication number Publication date
PT85904A (en) 1987-11-01
JP2744910B2 (ja) 1998-04-28
FI874495A0 (fi) 1987-10-12
AU7956487A (en) 1988-04-14
US5656721A (en) 1997-08-12
WO1988002756A2 (en) 1988-04-21
GB2199831A (en) 1988-07-20
GB2199831B (en) 1991-04-17
LU87014A1 (fr) 1988-05-03
GB8800537D0 (en) 1988-02-10
DK532787A (da) 1988-04-14
GB2199829B (en) 1991-04-17
AU634664B2 (en) 1993-02-25
IE912442A1 (en) 1992-02-12
GB2199829A (en) 1988-07-20
HUT46710A (en) 1988-11-28
CH680512A5 (enExample) 1992-09-15
PL268173A1 (en) 1988-09-01
ES2007418A6 (es) 1989-06-16
NL194729C (nl) 2003-01-07
DK532787D0 (da) 1987-10-12
SE8703938D0 (sv) 1987-10-12
FR2609991B1 (enExample) 1995-03-10
JPH0314599A (ja) 1991-01-23
GB8723737D0 (en) 1987-11-11
PL157156B1 (pl) 1992-05-29
HU906340D0 (en) 1991-04-29
CA1340985C (en) 2000-05-09
GR871567B (en) 1988-02-16
DK174337B1 (da) 2002-12-16
FI874495A7 (fi) 1988-04-14
HU206890B (en) 1993-01-28
PT85904B (pt) 1990-08-31
HU906341D0 (en) 1991-04-29
KR880005153A (ko) 1988-06-28
DE3790635T1 (enExample) 1988-10-06
SE518630C2 (sv) 2002-11-05
AU8015091A (en) 1991-10-31
CH682632A5 (de) 1993-10-29
FI874495L (fi) 1988-04-14
NZ222133A (en) 1993-02-25
KR960016861B1 (ko) 1996-12-23
FR2609991A1 (fr) 1988-07-29
WO1988002756A3 (en) 1988-07-14
IE912442L (en) 1988-04-13
SE9301172L (enExample) 1900-01-01
JPH0645639B2 (ja) 1994-06-15
SE9301172D0 (sv) 1993-04-07
SE8703938L (sv) 1988-04-14
JPS63101399A (ja) 1988-05-06
NL194729B (nl) 2002-09-02
NL8702345A (nl) 1988-05-02
BE1003752A4 (fr) 1992-06-09

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