DE3790635T1 - - Google Patents

Info

Publication number
DE3790635T1
DE3790635T1 DE19873790635 DE3790635T DE3790635T1 DE 3790635 T1 DE3790635 T1 DE 3790635T1 DE 19873790635 DE19873790635 DE 19873790635 DE 3790635 T DE3790635 T DE 3790635T DE 3790635 T1 DE3790635 T1 DE 3790635T1
Authority
DE
Germany
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19873790635
Other languages
German (de)
Other versions
DE3790635B4 (de
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of DE3790635T1 publication Critical patent/DE3790635T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE19873790635 1986-10-13 1987-10-12 Pending DE3790635T1 (enExample)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE3634825 1986-10-13
DE3634826 1986-10-13
DE3634797 1986-10-13
DE3712626 1987-04-14
CH315387 1987-08-17

Publications (1)

Publication Number Publication Date
DE3790635T1 true DE3790635T1 (enExample) 1988-10-06

Family

ID=27509117

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19873790635 Pending DE3790635T1 (enExample) 1986-10-13 1987-10-12

Country Status (23)

Country Link
US (1) US5656721A (enExample)
JP (2) JPH0645639B2 (enExample)
KR (1) KR960016861B1 (enExample)
AU (2) AU617986B2 (enExample)
BE (1) BE1003752A4 (enExample)
CA (1) CA1340985C (enExample)
CH (2) CH680512A5 (enExample)
DE (1) DE3790635T1 (enExample)
DK (1) DK174337B1 (enExample)
ES (1) ES2007418A6 (enExample)
FI (1) FI874495A7 (enExample)
FR (1) FR2609991A1 (enExample)
GB (2) GB2199829B (enExample)
GR (1) GR871567B (enExample)
HU (3) HU906340D0 (enExample)
IE (1) IE912442A1 (enExample)
LU (1) LU87014A1 (enExample)
NL (1) NL194729C (enExample)
NZ (1) NZ222133A (enExample)
PL (1) PL157156B1 (enExample)
PT (1) PT85904B (enExample)
SE (2) SE8703938L (enExample)
WO (1) WO1988002756A2 (enExample)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
AU632468B2 (en) * 1988-02-01 1993-01-07 Upjohn Company, The Renin inhibiting peptides with polar end groups
GB2218102B (en) * 1988-04-08 1992-09-16 Sandoz Ltd Calcitonin peptide derivatives
DE3910667A1 (de) * 1988-04-11 1989-10-19 Sandoz Ag Peptidderivate
GB8813339D0 (en) * 1988-06-06 1988-07-13 Sandoz Ltd Improvements in/relating to organic compounds
BE1003762A3 (fr) * 1988-11-11 1992-06-09 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives.
US5776894A (en) * 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
IT1229514B (it) * 1989-01-30 1991-09-03 Farmhispania S A A Montme Glicoconiugati anfifilici sintetici per impiego neurologico.
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
IT1260156B (it) * 1992-08-03 1996-03-28 Fidia Spa Derivati dell'acido neuraminico
TW263437B (enExample) * 1992-09-24 1995-11-21 Takeda Pharm Industry Co Ltd
US5710244A (en) * 1992-12-31 1998-01-20 Labroo; Virender M. Derivatized calcitonins
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
SG75092A1 (en) * 1993-08-09 2000-09-19 Biomeasure Inc Therapeutic peptide derivatives
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
JP3896430B2 (ja) * 1996-07-15 2007-03-22 アークレイ株式会社 糖化アミノ化合物の製造方法
IL119029A0 (en) 1996-08-07 1996-11-14 Yeda Res & Dev Long-acting drugs and pharamaceutical compositions comprising them
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
PT981363E (pt) 1997-05-13 2003-12-31 Conseils De Rec Appl Scient S Somatostatina e agonistas da somatostatina para reduzir o peso corporal
EP0981364B1 (en) 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Method and compositions for treating hyperlipidemia
JP4372345B2 (ja) * 1998-02-13 2009-11-25 アミリン・ファーマシューティカルズ，インコーポレイテッド 新規な混合アミリン活性化合物
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US20050037490A1 (en) * 1999-10-29 2005-02-17 Lawrence Rosenberg Medium for preparing dedifferentiated cells
US7589061B2 (en) * 2001-04-23 2009-09-15 Mallinckrodt Inc. Tc and Re labeler radioactive glycosylated octreotide derivatives
RU2277539C2 (ru) 2001-06-08 2006-06-10 Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик С.А.С. Химерные аналоги соматостатина-дофамина
DK1480998T3 (da) * 2002-02-27 2007-03-26 Ferring Bv Mellemprodukter og fremgangsmåder til fremstilling af heptapeptidoxytocinanaloger
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1928484B1 (en) 2005-08-26 2010-02-24 The Board Of Trustees Of The Leland Stanford Junior University Methods for treatment of headaches by administration of oxytocin
PT1787658E (pt) 2005-11-10 2012-06-22 Chemi Spa Formulações de libertação sustentada de análogos de somatostatina inibidores da hormona do crescimento
WO2008011168A2 (en) * 2006-07-21 2008-01-24 Amgen Inc. Glycosylated peptide antagonists of the bradykinin b1 receptor
EP2118123B1 (en) 2007-01-31 2015-10-14 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP3159352B1 (en) 2007-03-28 2023-08-02 President and Fellows of Harvard College Stitched polypeptides
CA2700587A1 (en) 2007-09-25 2009-04-02 Glycom A/S Glycoproteins and glycosylated cells and a method for the preparation of the same
AU2008323683B2 (en) * 2007-11-09 2014-10-02 University Of Tennessee Research Foundation Anti-inflammatory quinic acid derivatives for oral administration
EP3590956A1 (en) 2008-06-12 2020-01-08 Ipsen Bioinnovation Limited Suppression of neuroendocrine diseases
EP2310029B1 (en) 2008-06-12 2019-04-03 Ipsen Bioinnovation Limited Fusion proteins for use in the treatment of cancer
WO2010089757A2 (en) * 2008-11-07 2010-08-12 Usv Limited An improved process for synthesis of cyclic octapeptide
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
KR102104762B1 (ko) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
SG11201400293UA (en) 2011-09-04 2014-08-28 Glytech Inc Glycosylated polypeptide and drug composition containing said polypeptide
IN2014CN02399A (enExample) 2011-09-04 2015-06-19 Glytech Inc
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
NZ627528A (en) 2012-02-15 2016-05-27 Aileron Therapeutics Inc Peptidomimetic macrocycles
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
DK3007704T3 (da) 2013-06-13 2021-03-29 Antisense Therapeutics Ltd Kombinationsterapi til akromegali
KR20170058424A (ko) 2014-09-24 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 용도
JP7030517B2 (ja) 2015-01-07 2022-03-07 トライジェミナ， インコーポレイテッド マグネシウム含有オキシトシン製剤および使用の方法
SG11201707750YA (en) 2015-03-20 2017-10-30 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
CN115814055A (zh) 2016-04-12 2023-03-21 三叉神经股份公司 含镁催产素制剂和应用方法
EP3713545A1 (en) 2017-11-22 2020-09-30 Dauntless 1, Inc. Therapeutic compound formulations
EP3713660A1 (en) 2017-11-22 2020-09-30 Dauntless 1, Inc. Membrane emulsification device for microsphere creation
WO2020005842A1 (en) 2018-06-25 2020-01-02 Dauntless 2, Inc. Membrane emulsification device with impeller for microsphere creation
EP3956343A1 (en) 2019-04-16 2022-02-23 Bachem Holding AG Manufacture of disulfide bonded peptides
CA3199254A1 (en) * 2020-10-22 2022-04-28 The Trustees Of Indiana University Molecular designs of glucose-responsive and glucose-cleavable insulin analogues
WO2025229200A1 (en) 2024-05-03 2025-11-06 Bachem Holding Ag Manufacture of disulfide bonded peptides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4478746A (en) * 1982-11-17 1984-10-23 Kim Wan S Glycosylated insulin derivatives
US4483792A (en) * 1982-11-17 1984-11-20 Kim Wan S Glycosylated insulin derivatives
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254023A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Synthesis of peptide alcohols by the solid phase method
US4280953A (en) * 1979-11-08 1981-07-28 The Salk Institute For Biological Studies Glycosylated analogs of somatostatin
CY1327A (en) * 1979-11-27 1986-06-27 Sandoz Ag Novel polypeptides,processes for their production,pharmaceutical compositions comprising said polypeptides and their use
FR2522967B1 (fr) * 1982-03-15 1986-03-07 Anvar Conjugues d'haptenes et de muramyl-peptides, doues d'activite immunogene et compositions les contenant
FR2546163B1 (fr) * 1983-05-16 1987-10-09 Centre Nat Rech Scient Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
FR2548673B1 (fr) * 1983-07-05 1985-10-04 Essilor Int Polymeres supports de produits actifs relargables et leur procede de preparation
LU85269A1 (fr) * 1984-03-26 1985-10-14 Techland S A Composes nouveaux de somatostatine,procede pour leur synthese,preparation a usage veterinaire contenant lesdits composes et procede pour le traitement d'animaux
US4564998A (en) * 1984-10-19 1986-01-21 Westinghouse Electric Corp. Coil winding methods and apparatus
EP0192611A3 (de) * 1985-02-20 1988-05-11 Ciba-Geigy Ag Acylierte Hexosederivate und Verfahren zu ihrer Herstellung
JPS61264260A (ja) * 1985-05-17 1986-11-22 Rikagaku Kenkyusho アルデヒド化多孔性高分子材料によるタンパク質の除去方法
CA1337041C (en) * 1985-10-09 1995-09-19 Brett Alan Evans Granular detergent compositions having improved solubility
SE8506094D0 (sv) * 1985-12-20 1985-12-20 Astra Laekemedel Ab New antibacterial agents and intermediates therefor
JPS63165410A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製造方法
JPS63165411A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製法
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
US4859736A (en) * 1987-03-30 1989-08-22 Ciba-Geigy Corporation Synthetic polystyrene resin and its use in solid phase peptide synthesis
CH679045A5 (enExample) * 1987-06-29 1991-12-13 Sandoz Ag

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4478746A (en) * 1982-11-17 1984-10-23 Kim Wan S Glycosylated insulin derivatives
US4483792A (en) * 1982-11-17 1984-11-20 Kim Wan S Glycosylated insulin derivatives
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin

Also Published As

Publication number Publication date
PL268173A1 (en) 1988-09-01
PT85904A (en) 1987-11-01
SE9301172D0 (sv) 1993-04-07
AU617986B2 (en) 1991-12-12
JPS63101399A (ja) 1988-05-06
HU206890B (en) 1993-01-28
AU8015091A (en) 1991-10-31
CH680512A5 (enExample) 1992-09-15
NL194729B (nl) 2002-09-02
WO1988002756A3 (en) 1988-07-14
GB2199831B (en) 1991-04-17
NZ222133A (en) 1993-02-25
US5656721A (en) 1997-08-12
PT85904B (pt) 1990-08-31
ES2007418A6 (es) 1989-06-16
GB2199831A (en) 1988-07-20
JPH0314599A (ja) 1991-01-23
KR960016861B1 (ko) 1996-12-23
IE912442A1 (en) 1992-02-12
SE9301172L (enExample) 1900-01-01
LU87014A1 (fr) 1988-05-03
KR880005153A (ko) 1988-06-28
HU906340D0 (en) 1991-04-29
HUT46710A (en) 1988-11-28
FI874495A0 (fi) 1987-10-12
JP2744910B2 (ja) 1998-04-28
BE1003752A4 (fr) 1992-06-09
GB2199829A (en) 1988-07-20
SE8703938L (sv) 1988-04-14
DK532787D0 (da) 1987-10-12
GR871567B (en) 1988-02-16
AU7956487A (en) 1988-04-14
FR2609991A1 (fr) 1988-07-29
SE8703938D0 (sv) 1987-10-12
FI874495L (fi) 1988-04-14
IE912442L (en) 1988-04-13
CH682632A5 (de) 1993-10-29
DK532787A (da) 1988-04-14
AU634664B2 (en) 1993-02-25
PL157156B1 (pl) 1992-05-29
GB2199829B (en) 1991-04-17
JPH0645639B2 (ja) 1994-06-15
DK174337B1 (da) 2002-12-16
SE518630C2 (sv) 2002-11-05
NL194729C (nl) 2003-01-07
NL8702345A (nl) 1988-05-02
FR2609991B1 (enExample) 1995-03-10
CA1340985C (en) 2000-05-09
HU906341D0 (en) 1991-04-29
GB8800537D0 (en) 1988-02-10
WO1988002756A2 (en) 1988-04-21
FI874495A7 (fi) 1988-04-14
GB8723737D0 (en) 1987-11-11

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Legal Events

Date Code Title Description
8180 Miscellaneous part 1

Free format text: 13.10.86 DE 36 34 797.3 13.10.86 DE 36 34 825.2 13.10.86 DE 36 34 826.0 14.04.87 03 DE 37 12 626.1

8141 Disposal/no request for examination
8110 Request for examination paragraph 44
8170 Reinstatement of the former position
8127 New person/name/address of the applicant

Owner name: NOVARTIS AG, BASEL, CH