DK1480998T3 - Mellemprodukter og fremgangsmåder til fremstilling af heptapeptidoxytocinanaloger - Google Patents
Mellemprodukter og fremgangsmåder til fremstilling af heptapeptidoxytocinanalogerInfo
- Publication number
- DK1480998T3 DK1480998T3 DK03743130T DK03743130T DK1480998T3 DK 1480998 T3 DK1480998 T3 DK 1480998T3 DK 03743130 T DK03743130 T DK 03743130T DK 03743130 T DK03743130 T DK 03743130T DK 1480998 T3 DK1480998 T3 DK 1480998T3
- Authority
- DK
- Denmark
- Prior art keywords
- intermediates
- methods
- preparing
- analogs
- synthesizing
- Prior art date
Links
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 title abstract 4
- 239000000543 intermediate Substances 0.000 title abstract 3
- 230000002194 synthesizing effect Effects 0.000 abstract 4
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 1
- 101800000989 Oxytocin Proteins 0.000 abstract 1
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 229960001723 oxytocin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36034502P | 2002-02-27 | 2002-02-27 | |
| PCT/US2003/004301 WO2003072597A1 (en) | 2002-02-27 | 2003-02-13 | Intermediates and methods for making heptapeptide oxytocin analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1480998T3 true DK1480998T3 (da) | 2007-03-26 |
Family
ID=27766223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03743130T DK1480998T3 (da) | 2002-02-27 | 2003-02-13 | Mellemprodukter og fremgangsmåder til fremstilling af heptapeptidoxytocinanaloger |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7091314B2 (da) |
| EP (1) | EP1480998B1 (da) |
| JP (1) | JP4615221B2 (da) |
| AT (1) | ATE346084T1 (da) |
| AU (1) | AU2003211011A1 (da) |
| DE (1) | DE60309847T2 (da) |
| DK (1) | DK1480998T3 (da) |
| ES (1) | ES2277640T3 (da) |
| PT (1) | PT1480998E (da) |
| WO (1) | WO2003072597A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8673841B2 (en) | 2008-03-31 | 2014-03-18 | Ferring B.V. | Oxytocin analogues |
| WO2010002473A1 (en) | 2008-07-03 | 2010-01-07 | University Of Virginia Patent Foundation | Unit dosage of apadenoson |
| TWI463990B (zh) | 2009-09-21 | 2014-12-11 | Ferring Bv | 催產素受體促進劑 |
| EP3501533A1 (en) | 2014-12-22 | 2019-06-26 | Ferring B.V. | Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies |
| CN108290929A (zh) * | 2015-10-06 | 2018-07-17 | 辉凌公司 | 制造巴芦西班及其中间体的新型方法 |
| JP6933322B2 (ja) | 2016-01-04 | 2021-09-08 | メルク セローノ エス．エー． | ヒドロキシプロピルチアゾリジンカルボキサミド誘導体のｌ−バリネート及びその塩形態、結晶多形 |
| UA127283C2 (uk) | 2016-07-21 | 2023-07-12 | Обсева С.А. | Спосіб застосування антагоніста окситоцину для сприяння імплантації ембріона і запобігання викидню |
| CN114667141A (zh) | 2019-09-03 | 2022-06-24 | 奥布赛瓦股份公司 | 用于促进胚胎移植和预防流产的催产素拮抗剂给药方案 |
| AU2021218895A1 (en) | 2020-02-10 | 2022-09-15 | ObsEva S.A. | Biomarkers for oxytocin receptor antagonist therapy |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL194729C (nl) * | 1986-10-13 | 2003-01-07 | Novartis Ag | Werkwijze voor de bereiding van peptidealcoholen via vaste fase. |
| SE9002384D0 (sv) | 1990-07-09 | 1990-07-09 | Ferring Ab | Derivat av baklobshormoner |
| JP3158507B2 (ja) * | 1991-07-09 | 2001-04-23 | チッソ株式会社 | 光学活性３−フェニル−３−ヒドロキシプロピオン酸エステルの製造方法 |
| FR2680506B1 (fr) * | 1991-08-19 | 1994-09-02 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la beta-phenylisoserine et leur utilisation. |
| SE501678C2 (sv) | 1993-07-13 | 1995-04-10 | Ferring Bv | Peptid med oxytocinantagonistaktivitet samt farmaceutisk komposition innehållande nämnda peptid |
| US5856721A (en) * | 1994-09-08 | 1999-01-05 | Gordin; Myron K. | Discharge lamp with offset or tilted arc tube |
| US5858972A (en) * | 1996-01-11 | 1999-01-12 | La Jolla Cancer Research Foundation | Antithrombotic agents and methods of use |
| SE9604341D0 (sv) * | 1996-11-26 | 1996-11-26 | Ferring Bv | Hepta-peptide oxytocin analogue |
| US6245746B1 (en) * | 1998-01-23 | 2001-06-12 | Microcide Pharmaceuticals, Inc. | Efflux pump inhibitors |
| US6204279B1 (en) * | 1998-06-03 | 2001-03-20 | Microcide Pharmaceuticals, Inc. | Peptidomimetic efflux pump inhibitors |
| US6114310A (en) * | 1998-01-23 | 2000-09-05 | Microcide Pharmaceuticals, Inc. | Efflux pump inhibitors |
| ES2144357B1 (es) * | 1998-01-29 | 2000-12-16 | Lipotec Sa | Procedimiento para la obtencion del analogo de somatostatina octreotide. |
| GB0115515D0 (en) | 2001-06-25 | 2001-08-15 | Ferring Bv | Oxytocin agonisys |
-
2003
- 2003-02-13 JP JP2003571303A patent/JP4615221B2/ja not_active Expired - Fee Related
- 2003-02-13 DK DK03743130T patent/DK1480998T3/da active
- 2003-02-13 PT PT03743130T patent/PT1480998E/pt unknown
- 2003-02-13 EP EP03743130A patent/EP1480998B1/en not_active Expired - Lifetime
- 2003-02-13 AT AT03743130T patent/ATE346084T1/de active
- 2003-02-13 AU AU2003211011A patent/AU2003211011A1/en not_active Abandoned
- 2003-02-13 WO PCT/US2003/004301 patent/WO2003072597A1/en active IP Right Grant
- 2003-02-13 DE DE60309847T patent/DE60309847T2/de not_active Expired - Lifetime
- 2003-02-13 ES ES03743130T patent/ES2277640T3/es not_active Expired - Lifetime
-
2004
- 2004-07-08 US US10/888,704 patent/US7091314B2/en not_active Expired - Lifetime
-
2006
- 2006-07-14 US US11/457,743 patent/US7304181B2/en not_active Expired - Fee Related
-
2007
- 2007-10-30 US US11/929,494 patent/US7816489B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1480998B1 (en) | 2006-11-22 |
| EP1480998A4 (en) | 2005-06-08 |
| JP4615221B2 (ja) | 2011-01-19 |
| JP2005532996A (ja) | 2005-11-04 |
| US7816489B2 (en) | 2010-10-19 |
| US20080177035A1 (en) | 2008-07-24 |
| DE60309847D1 (de) | 2007-01-04 |
| ATE346084T1 (de) | 2006-12-15 |
| AU2003211011A1 (en) | 2003-09-09 |
| US7304181B2 (en) | 2007-12-04 |
| US20040248776A1 (en) | 2004-12-09 |
| DE60309847T2 (de) | 2007-10-18 |
| PT1480998E (pt) | 2007-02-28 |
| WO2003072597A1 (en) | 2003-09-04 |
| US7091314B2 (en) | 2006-08-15 |
| ES2277640T3 (es) | 2007-07-16 |
| EP1480998A1 (en) | 2004-12-01 |
| US20060247157A1 (en) | 2006-11-02 |
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