ATE346084T1 - Zwischenprodukte und verfahren zur herstellung von heptapeptid-oxytocinanaloga - Google Patents
Zwischenprodukte und verfahren zur herstellung von heptapeptid-oxytocinanalogaInfo
- Publication number
- ATE346084T1 ATE346084T1 AT03743130T AT03743130T ATE346084T1 AT E346084 T1 ATE346084 T1 AT E346084T1 AT 03743130 T AT03743130 T AT 03743130T AT 03743130 T AT03743130 T AT 03743130T AT E346084 T1 ATE346084 T1 AT E346084T1
- Authority
- AT
- Austria
- Prior art keywords
- analogs
- heptapeptide
- oxytocine
- producing
- intermediate products
- Prior art date
Links
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 title abstract 4
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000002194 synthesizing effect Effects 0.000 abstract 4
- 239000000543 intermediate Substances 0.000 abstract 2
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 1
- 101800000989 Oxytocin Proteins 0.000 abstract 1
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 229960001723 oxytocin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36034502P | 2002-02-27 | 2002-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE346084T1 true ATE346084T1 (de) | 2006-12-15 |
Family
ID=27766223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03743130T ATE346084T1 (de) | 2002-02-27 | 2003-02-13 | Zwischenprodukte und verfahren zur herstellung von heptapeptid-oxytocinanaloga |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7091314B2 (de) |
| EP (1) | EP1480998B1 (de) |
| JP (1) | JP4615221B2 (de) |
| AT (1) | ATE346084T1 (de) |
| AU (1) | AU2003211011A1 (de) |
| DE (1) | DE60309847T2 (de) |
| DK (1) | DK1480998T3 (de) |
| ES (1) | ES2277640T3 (de) |
| PT (1) | PT1480998E (de) |
| WO (1) | WO2003072597A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010010743A (es) | 2008-03-31 | 2010-11-04 | Ferring Bv | Analogos de oxitocina. |
| US20100003193A1 (en) | 2008-07-03 | 2010-01-07 | University Of Virginia Patent Foundation | Unit dosage of apadenoson |
| TWI463990B (zh) | 2009-09-21 | 2014-12-11 | Ferring Bv | 催產素受體促進劑 |
| EP3037101B1 (de) | 2014-12-22 | 2019-03-06 | Ferring B.V. | Oxytocinrezeptorantagonistentherapie in der Lutealphase für Implantation und Schwangerschaft bei mit Technologien zur unterstützten Fortpflanzung behandelten Frauen |
| MX2018004282A (es) * | 2015-10-06 | 2018-08-09 | Ferring Bv | Nuevos procedimientos de fabricacion de barusiban y sus intermedios. |
| MX2018008157A (es) | 2016-01-04 | 2018-09-03 | ObsEva SA | Alfa-amino esteres de derivado de hidroxipropiltiazolidin carboxamida, y formas de sales y polimorfos cristalinos de estos. |
| CN109689048B (zh) | 2016-07-21 | 2022-10-28 | 奥布赛瓦股份公司 | 促进胚胎植入和预防流产的催产素拮抗剂给药方案 |
| KR20220075340A (ko) | 2019-09-03 | 2022-06-08 | 옵스에파 에스에이 | 배아 착상을 촉진하고 유산을 예방하기 위한 옥시토신 길항제 투여 요법 |
| WO2021160597A1 (en) | 2020-02-10 | 2021-08-19 | ObsEva S.A. | Biomarkers for oxytocin receptor antagonist therapy |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU206890B (en) * | 1986-10-13 | 1993-01-28 | Sandoz Ag | Process for producing sugar-modified somatostatin peptide derivatives and pharmaceutical compositions containing them as active components |
| SE9002384D0 (sv) | 1990-07-09 | 1990-07-09 | Ferring Ab | Derivat av baklobshormoner |
| JP3158507B2 (ja) * | 1991-07-09 | 2001-04-23 | チッソ株式会社 | 光学活性３−フェニル−３−ヒドロキシプロピオン酸エステルの製造方法 |
| FR2680506B1 (fr) * | 1991-08-19 | 1994-09-02 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la beta-phenylisoserine et leur utilisation. |
| SE501678C2 (sv) | 1993-07-13 | 1995-04-10 | Ferring Bv | Peptid med oxytocinantagonistaktivitet samt farmaceutisk komposition innehållande nämnda peptid |
| US5856721A (en) * | 1994-09-08 | 1999-01-05 | Gordin; Myron K. | Discharge lamp with offset or tilted arc tube |
| US5858972A (en) * | 1996-01-11 | 1999-01-12 | La Jolla Cancer Research Foundation | Antithrombotic agents and methods of use |
| SE9604341D0 (sv) * | 1996-11-26 | 1996-11-26 | Ferring Bv | Hepta-peptide oxytocin analogue |
| US6204279B1 (en) * | 1998-06-03 | 2001-03-20 | Microcide Pharmaceuticals, Inc. | Peptidomimetic efflux pump inhibitors |
| US6114310A (en) * | 1998-01-23 | 2000-09-05 | Microcide Pharmaceuticals, Inc. | Efflux pump inhibitors |
| US6245746B1 (en) * | 1998-01-23 | 2001-06-12 | Microcide Pharmaceuticals, Inc. | Efflux pump inhibitors |
| ES2144357B1 (es) * | 1998-01-29 | 2000-12-16 | Lipotec Sa | Procedimiento para la obtencion del analogo de somatostatina octreotide. |
| GB0115515D0 (en) | 2001-06-25 | 2001-08-15 | Ferring Bv | Oxytocin agonisys |
-
2003
- 2003-02-13 PT PT03743130T patent/PT1480998E/pt unknown
- 2003-02-13 ES ES03743130T patent/ES2277640T3/es not_active Expired - Lifetime
- 2003-02-13 EP EP03743130A patent/EP1480998B1/de not_active Expired - Lifetime
- 2003-02-13 DK DK03743130T patent/DK1480998T3/da active
- 2003-02-13 AU AU2003211011A patent/AU2003211011A1/en not_active Abandoned
- 2003-02-13 DE DE60309847T patent/DE60309847T2/de not_active Expired - Lifetime
- 2003-02-13 JP JP2003571303A patent/JP4615221B2/ja not_active Expired - Fee Related
- 2003-02-13 WO PCT/US2003/004301 patent/WO2003072597A1/en active IP Right Grant
- 2003-02-13 AT AT03743130T patent/ATE346084T1/de active
-
2004
- 2004-07-08 US US10/888,704 patent/US7091314B2/en not_active Expired - Lifetime
-
2006
- 2006-07-14 US US11/457,743 patent/US7304181B2/en not_active Expired - Fee Related
-
2007
- 2007-10-30 US US11/929,494 patent/US7816489B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60309847D1 (de) | 2007-01-04 |
| AU2003211011A1 (en) | 2003-09-09 |
| US7304181B2 (en) | 2007-12-04 |
| US20060247157A1 (en) | 2006-11-02 |
| WO2003072597A1 (en) | 2003-09-04 |
| DK1480998T3 (da) | 2007-03-26 |
| US7816489B2 (en) | 2010-10-19 |
| JP2005532996A (ja) | 2005-11-04 |
| EP1480998A4 (de) | 2005-06-08 |
| JP4615221B2 (ja) | 2011-01-19 |
| US20040248776A1 (en) | 2004-12-09 |
| PT1480998E (pt) | 2007-02-28 |
| US7091314B2 (en) | 2006-08-15 |
| DE60309847T2 (de) | 2007-10-18 |
| ES2277640T3 (es) | 2007-07-16 |
| EP1480998B1 (de) | 2006-11-22 |
| US20080177035A1 (en) | 2008-07-24 |
| EP1480998A1 (de) | 2004-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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