AU2016362129A1 - Compositions and methods for immunooncology - Google Patents

Compositions and methods for immunooncology Download PDF

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Publication number
AU2016362129A1
AU2016362129A1 AU2016362129A AU2016362129A AU2016362129A1 AU 2016362129 A1 AU2016362129 A1 AU 2016362129A1 AU 2016362129 A AU2016362129 A AU 2016362129A AU 2016362129 A AU2016362129 A AU 2016362129A AU 2016362129 A1 AU2016362129 A1 AU 2016362129A1
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AU
Australia
Prior art keywords
seq
targeting domain
cell
grna molecule
grna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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AU2016362129A
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English (en)
Inventor
Ming-Wei Chen
Melissa DECK
Glenn Dranoff
Reynald LESCARBEAU
Craig MICKANIN
Celeste RICHARDSON
Morag Stewart
Yi Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Intellia Therapeutics Inc
Original Assignee
Novartis AG
Intellia Therapeutics Inc
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Publication date
Application filed by Novartis AG, Intellia Therapeutics Inc filed Critical Novartis AG
Publication of AU2016362129A1 publication Critical patent/AU2016362129A1/en
Priority to AU2020230334A priority Critical patent/AU2020230334A1/en
Priority to AU2023201162A priority patent/AU2023201162A1/en
Priority to AU2026200217A priority patent/AU2026200217A1/en
Abandoned legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N5/0634—Cells from the blood or the immune system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2320/30—Special therapeutic applications
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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AU2016362129A 2015-12-04 2016-12-02 Compositions and methods for immunooncology Abandoned AU2016362129A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2020230334A AU2020230334A1 (en) 2015-12-04 2020-09-11 Compositions and methods for immunooncology
AU2023201162A AU2023201162A1 (en) 2015-12-04 2023-02-27 Compositions and methods for immunooncology
AU2026200217A AU2026200217A1 (en) 2015-12-04 2026-01-14 Compositions and methods for immunooncology

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562263169P 2015-12-04 2015-12-04
US62/263,169 2015-12-04
US201662316784P 2016-04-01 2016-04-01
US62/316,784 2016-04-01
US201662394290P 2016-09-14 2016-09-14
US62/394,290 2016-09-14
PCT/IB2016/057318 WO2017093969A1 (en) 2015-12-04 2016-12-02 Compositions and methods for immunooncology

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020230334A Division AU2020230334A1 (en) 2015-12-04 2020-09-11 Compositions and methods for immunooncology

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