AU2014207691B2 - Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors - Google Patents
Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors Download PDFInfo
- Publication number
- AU2014207691B2 AU2014207691B2 AU2014207691A AU2014207691A AU2014207691B2 AU 2014207691 B2 AU2014207691 B2 AU 2014207691B2 AU 2014207691 A AU2014207691 A AU 2014207691A AU 2014207691 A AU2014207691 A AU 2014207691A AU 2014207691 B2 AU2014207691 B2 AU 2014207691B2
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- Prior art keywords
- amino
- pyridin
- hydroxy
- dihydro
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 0 C1C*2*=CC=CC2C1 Chemical compound C1C*2*=CC=CC2C1 0.000 description 5
- GNVVZBPTKBVJEF-UHFFFAOYSA-N C=C(c1c[s]c(-c(c(F)ccc2)c2F)n1)O Chemical compound C=C(c1c[s]c(-c(c(F)ccc2)c2F)n1)O GNVVZBPTKBVJEF-UHFFFAOYSA-N 0.000 description 1
- ORLIJSLUZXIXPU-JXFKEZNVSA-N CC(C)(C)CC[C@@H](CN(CC1)c2c(CCC3)c3ncc2N)[C@H]1O/[O]=C(\N)/OC(C)(C)C Chemical compound CC(C)(C)CC[C@@H](CN(CC1)c2c(CCC3)c3ncc2N)[C@H]1O/[O]=C(\N)/OC(C)(C)C ORLIJSLUZXIXPU-JXFKEZNVSA-N 0.000 description 1
- IKLFTJQKKCELGD-UHFFFAOYSA-N CC(C)(C)OC(NC1(C)CNCCC1)=O Chemical compound CC(C)(C)OC(NC1(C)CNCCC1)=O IKLFTJQKKCELGD-UHFFFAOYSA-N 0.000 description 1
- KLWQONUFEZDNIG-HNNXBMFYSA-N CC(C)(C)OC(N[C@@H](CCC1)CN1c(c([s]cc1)c1nc1)c1NC(c1c[s]c(-c(c(F)ccc2)c2F)n1)=O)=O Chemical compound CC(C)(C)OC(N[C@@H](CCC1)CN1c(c([s]cc1)c1nc1)c1NC(c1c[s]c(-c(c(F)ccc2)c2F)n1)=O)=O KLWQONUFEZDNIG-HNNXBMFYSA-N 0.000 description 1
- FCTSCNKIZHMSRS-UHFFFAOYSA-N CC(C)(C)OC(Nc1c(C(OC)=O)nc(-c(c(F)ccc2)c2F)[s]1)=O Chemical compound CC(C)(C)OC(Nc1c(C(OC)=O)nc(-c(c(F)ccc2)c2F)[s]1)=O FCTSCNKIZHMSRS-UHFFFAOYSA-N 0.000 description 1
- ZEUUYKVEGQRRDH-UHFFFAOYSA-N CC(CCc1c2N(CCC3)CC3N)c1ncc2NC(c1c(N)ncc(-c(c(F)ccc2)c2F)n1)O Chemical compound CC(CCc1c2N(CCC3)CC3N)c1ncc2NC(c1c(N)ncc(-c(c(F)ccc2)c2F)n1)O ZEUUYKVEGQRRDH-UHFFFAOYSA-N 0.000 description 1
- PQZURWBPBDDGIB-UHFFFAOYSA-N CC(CCc1c2N(CCC3)CC3NC(OC(C)(C)C)=O)c1ncc2NC(c(cc1)nc(-c(c(F)c(cc2)OC)c2F)c1F)=O Chemical compound CC(CCc1c2N(CCC3)CC3NC(OC(C)(C)C)=O)c1ncc2NC(c(cc1)nc(-c(c(F)c(cc2)OC)c2F)c1F)=O PQZURWBPBDDGIB-UHFFFAOYSA-N 0.000 description 1
- PEKWSRPFNSGXFL-LYKKTTPLSA-N CC(CCc1c2N(CCC3)C[C@H]3N)c1ncc2NC(c(cc1)nc(-c(c(F)cc(C)c2)c2F)c1F)=O Chemical compound CC(CCc1c2N(CCC3)C[C@H]3N)c1ncc2NC(c(cc1)nc(-c(c(F)cc(C)c2)c2F)c1F)=O PEKWSRPFNSGXFL-LYKKTTPLSA-N 0.000 description 1
- WPIMZMAFOWOVGM-OVRCFYHRSA-N C[C@@H](CN(C[C@H]1N)c(c2c(nc3)OCC2)c3NC(c(nc(c(F)c2)-c(c(F)ccc3)c3F)c2N)=O)[C@H]1O Chemical compound C[C@@H](CN(C[C@H]1N)c(c2c(nc3)OCC2)c3NC(c(nc(c(F)c2)-c(c(F)ccc3)c3F)c2N)=O)[C@H]1O WPIMZMAFOWOVGM-OVRCFYHRSA-N 0.000 description 1
- IGDLNAWHTASKKG-UHFFFAOYSA-N Clc1c(CCC2)c2ncc1 Chemical compound Clc1c(CCC2)c2ncc1 IGDLNAWHTASKKG-UHFFFAOYSA-N 0.000 description 1
- UALNXUQNOUVKIK-JTQLQIEISA-N N[C@@H](CCC1)CN1c(c(cn[nH]1)c1nc1)c1NC(c1c(N)[s]c(-c(c(F)ccc2)c2F)n1)=O Chemical compound N[C@@H](CCC1)CN1c(c(cn[nH]1)c1nc1)c1NC(c1c(N)[s]c(-c(c(F)ccc2)c2F)n1)=O UALNXUQNOUVKIK-JTQLQIEISA-N 0.000 description 1
- URNVZDFYVLSEAS-NSHDSACASA-N N[C@@H](CCC1)CN1c(c1c(nc2)[s]cc1)c2NC(c1c(N)[s]c(-c(c(F)ccc2)c2F)n1)=O Chemical compound N[C@@H](CCC1)CN1c(c1c(nc2)[s]cc1)c2NC(c1c(N)[s]c(-c(c(F)ccc2)c2F)n1)=O URNVZDFYVLSEAS-NSHDSACASA-N 0.000 description 1
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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