AU2012328453B2 - Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease - Google Patents

Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease Download PDF

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AU2012328453B2
AU2012328453B2 AU2012328453A AU2012328453A AU2012328453B2 AU 2012328453 B2 AU2012328453 B2 AU 2012328453B2 AU 2012328453 A AU2012328453 A AU 2012328453A AU 2012328453 A AU2012328453 A AU 2012328453A AU 2012328453 B2 AU2012328453 B2 AU 2012328453B2
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asbti
bile
bile acid
substituted
alkyl
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AU2012328453A1 (en
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Bronislava Gedulin
Michael GREY
Niall O'donnell
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Shire Human Genetics Therapies Inc
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Shire Human Genetics Therapies Inc
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Priority to AU2017210623A priority Critical patent/AU2017210623B2/en
Priority to AU2019226227A priority patent/AU2019226227B2/en
Assigned to SHIRE HUMAN GENETIC THERAPIES, INC. reassignment SHIRE HUMAN GENETIC THERAPIES, INC. Request for Assignment Assignors: LUMENA PHARMACEUTICALS LLC
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
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    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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AU2012328453A 2011-10-28 2012-10-26 Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease Active AU2012328453B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2017210623A AU2017210623B2 (en) 2011-10-28 2017-08-04 Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
AU2019226227A AU2019226227B2 (en) 2011-10-28 2019-09-06 Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease

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US201161553094P 2011-10-28 2011-10-28
US61/553,094 2011-10-28
US201261607487P 2012-03-06 2012-03-06
US61/607,487 2012-03-06
PCT/US2012/062303 WO2013063526A1 (en) 2011-10-28 2012-10-26 Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease

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