ATE388228T1 - Verfahren zur verknüpfung interessierender sequenzen - Google Patents
Verfahren zur verknüpfung interessierender sequenzenInfo
- Publication number
- ATE388228T1 ATE388228T1 AT04762853T AT04762853T ATE388228T1 AT E388228 T1 ATE388228 T1 AT E388228T1 AT 04762853 T AT04762853 T AT 04762853T AT 04762853 T AT04762853 T AT 04762853T AT E388228 T1 ATE388228 T1 AT E388228T1
- Authority
- AT
- Austria
- Prior art keywords
- extension
- variable region
- pcr
- cell receptors
- interest
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000003757 reverse transcription PCR Methods 0.000 abstract 2
- 108091008875 B cell receptors Proteins 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108091008874 T cell receptors Proteins 0.000 abstract 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 229940072221 immunoglobulins Drugs 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50445503P | 2003-09-18 | 2003-09-18 | |
| US50458903P | 2003-09-18 | 2003-09-18 | |
| DKPA200301867 | 2003-12-17 | ||
| DKPA200400782 | 2004-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE388228T1 true ATE388228T1 (de) | 2008-03-15 |
Family
ID=44209637
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08152066T ATE537256T1 (de) | 2003-09-18 | 2004-09-17 | Methode zur verbindung von besonderen sequenzen |
| AT04762853T ATE388228T1 (de) | 2003-09-18 | 2004-09-17 | Verfahren zur verknüpfung interessierender sequenzen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08152066T ATE537256T1 (de) | 2003-09-18 | 2004-09-17 | Methode zur verbindung von besonderen sequenzen |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7749697B2 (de) |
| EP (3) | EP1516929A3 (de) |
| JP (1) | JP4651619B2 (de) |
| CN (2) | CN1856571B (de) |
| AT (2) | ATE537256T1 (de) |
| AU (1) | AU2004286019B2 (de) |
| BR (1) | BRPI0414282A (de) |
| CA (1) | CA2539576A1 (de) |
| DE (1) | DE602004012299T2 (de) |
| DK (2) | DK1670912T3 (de) |
| ES (2) | ES2302542T3 (de) |
| MY (1) | MY148907A (de) |
| NZ (1) | NZ545936A (de) |
| PL (2) | PL1921144T3 (de) |
| PT (2) | PT1921144E (de) |
| SI (2) | SI1670912T1 (de) |
| TW (1) | TWI333977B (de) |
| WO (1) | WO2005042774A2 (de) |
Families Citing this family (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1583830E (pt) * | 2003-01-07 | 2006-11-30 | Symphogen As | Método para produzir proteínas policlonais recombinantes |
| US7993919B2 (en) * | 2003-11-19 | 2011-08-09 | The United States Of America As Represented By The Department Of Health And Human Services | Method of inducing memory B cell development and terminal differentiation |
| BRPI0513706A (pt) * | 2004-07-20 | 2008-05-13 | Symphogen As | anticorpo policlonal recombinante anti-rhesus d e métodos de produção |
| ES2332524T3 (es) * | 2004-07-20 | 2010-02-08 | Symphogen A/S | Un procedimiento para la caracterizacion de una linea celular policlonal. |
| EP2339001A2 (de) | 2005-03-25 | 2011-06-29 | National Research Council of Canada | Verfahren zur Isolation von löslichen Polypeptiden |
| EP1707628B1 (de) * | 2005-03-30 | 2009-11-11 | Sekisui Chemical Co., Ltd. | Verfahren zur Produktion von rekombinanten polyklonalen Immunglobulinen |
| CA2655511C (en) * | 2005-07-01 | 2017-03-21 | John Schrader | Methods of isolating cells and generating monoclonal antibodies |
| JP2009518320A (ja) * | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
| AU2007222798A1 (en) * | 2006-03-06 | 2007-09-13 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
| US7504106B2 (en) | 2006-03-14 | 2009-03-17 | Boris Skurkovich | Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis |
| RU2459868C2 (ru) * | 2007-03-01 | 2012-08-27 | Симфоген А/С | Способ клонирования когнатных антител |
| CN104151430A (zh) * | 2007-03-01 | 2014-11-19 | 西福根有限公司 | 重组抗表皮生长因子受体抗体组合物 |
| CN101679513A (zh) * | 2007-03-06 | 2010-03-24 | 西福根有限公司 | 用于治疗呼吸道合胞病毒感染的重组抗体 |
| EP2152872B1 (de) | 2007-05-25 | 2010-09-15 | Symphogen A/S | Verfahren zur herstellung eines rekombinanten polyklonalen proteins |
| JP2008289483A (ja) * | 2007-05-25 | 2008-12-04 | Symphogen As | 真核生物系において発現可能な形質転換体のスクリーニング |
| CA2695309A1 (en) * | 2007-09-07 | 2009-03-12 | Symphogen A/S | Methods for recombinant manufacturing of anti-rsv antibodies |
| US8268564B2 (en) * | 2007-09-26 | 2012-09-18 | President And Fellows Of Harvard College | Methods and applications for stitched DNA barcodes |
| US7792057B2 (en) * | 2007-12-21 | 2010-09-07 | At&T Labs, Inc. | Method and system for computing multicast traffic matrices |
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| EP2331689A4 (de) * | 2008-08-29 | 2012-10-31 | Symphogen As | Verfahren zum klonen von antikörpern aus vögeln |
| EP2331577B1 (de) * | 2008-08-29 | 2017-06-07 | Symphogen A/S | Zusammensetzungen rekombinanter antikörper gegen den rezeptor des epidermalen wachstumsfaktors |
| CA2739476A1 (en) * | 2008-10-06 | 2010-04-15 | Symphogen A/S | Method for identifying and selecting drug candidates for combinatorial drug products |
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| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| CN102272327B (zh) | 2008-11-07 | 2015-11-25 | 赛昆塔公司 | 通过序列分析监测状况的方法 |
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| DK2387627T3 (en) | 2009-01-15 | 2016-07-04 | Adaptive Biotechnologies Corp | Adaptive immunity profiling and methods for producing monoclonal antibodies |
| GB0903207D0 (en) | 2009-02-25 | 2009-04-08 | Ucb Pharma Sa | Method for expressing multimeric proteins |
| ES2700442T3 (es) * | 2009-02-25 | 2019-02-15 | Ucb Biopharma Sprl | Método para producir anticuerpos |
| US8563305B2 (en) | 2009-04-30 | 2013-10-22 | Oklahoma Medical Research Foundation | Rapid generation of antibodies |
| ES2511051T3 (es) | 2009-05-29 | 2014-10-22 | Morphosys Ag | Colección de anticuerpos sintéticos para tratar enfermedades |
| RU2539032C2 (ru) | 2009-06-25 | 2015-01-10 | Фред Хатчинсон Кансэр Рисёч Сентер | Способ измерения искусственного иммунитета |
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| KR102139388B1 (ko) | 2011-07-12 | 2020-07-30 | 엑스바이오테크, 인크. | 친화성 성숙 인간 항체의 동정 |
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