ATE527542T1 - Verfahren zur herstellung von abbildungssonden unter verwendung von click chemie - Google Patents
Verfahren zur herstellung von abbildungssonden unter verwendung von click chemieInfo
- Publication number
- ATE527542T1 ATE527542T1 AT06751892T AT06751892T ATE527542T1 AT E527542 T1 ATE527542 T1 AT E527542T1 AT 06751892 T AT06751892 T AT 06751892T AT 06751892 T AT06751892 T AT 06751892T AT E527542 T1 ATE527542 T1 AT E527542T1
- Authority
- AT
- Austria
- Prior art keywords
- imaging probe
- candidate
- library
- click chemistry
- identifying
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Steroid Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67529005P | 2005-04-27 | 2005-04-27 | |
PCT/US2006/016428 WO2006116736A2 (en) | 2005-04-27 | 2006-04-27 | A method for the preparation of imaging probes using click chemistry |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE527542T1 true ATE527542T1 (de) | 2011-10-15 |
Family
ID=36954603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06751892T ATE527542T1 (de) | 2005-04-27 | 2006-04-27 | Verfahren zur herstellung von abbildungssonden unter verwendung von click chemie |
Country Status (9)
Country | Link |
---|---|
US (1) | US20060269942A1 (de) |
EP (1) | EP1875239B1 (de) |
JP (1) | JP4790012B2 (de) |
KR (1) | KR100973156B1 (de) |
AT (1) | ATE527542T1 (de) |
CA (1) | CA2606477C (de) |
DK (1) | DK1875239T3 (de) |
ES (1) | ES2375495T3 (de) |
WO (1) | WO2006116736A2 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8071718B2 (en) | 2004-12-22 | 2011-12-06 | General Electric Company | Selective radiolabeling of biomolecules |
AU2006277117B2 (en) * | 2005-08-05 | 2013-01-10 | Syntarga B.V. | Triazole-containing releasable linkers and conjugates comprising the same |
WO2007105094A1 (en) | 2006-03-14 | 2007-09-20 | Universität Basel | Method for the identification of new leads for drug candidates |
US20100022481A1 (en) * | 2006-08-02 | 2010-01-28 | Dong Wang | Drug Carriers, Their Synthesis, and Methods of Use Thereof |
KR20090127433A (ko) * | 2007-04-05 | 2009-12-11 | 지멘스 메디컬 솔루션즈 유에스에이, 인크. | 클릭 화학을 이용한 탄산탈수효소―ⅰⅹ에 대한 분자 영상화 프로브의 제조 |
US8562945B2 (en) | 2008-01-09 | 2013-10-22 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof |
EP2823826A3 (de) | 2008-01-09 | 2015-03-25 | Molecular Insight Pharmaceuticals, Inc. | Kohlenstoffanhydrase-IX-Inhibitoren |
WO2009105746A2 (en) * | 2008-02-22 | 2009-08-27 | University Of South Florida | Triazoles and processes for producing the same |
CA2728733A1 (en) * | 2008-06-18 | 2009-12-23 | California Institute Of Technology | Multi-ligand capture agents and related compositions, methods and systems |
US8618297B2 (en) | 2008-07-25 | 2013-12-31 | Basf Se | Azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions |
WO2010051530A2 (en) | 2008-10-31 | 2010-05-06 | The General Hospital Corporation | Compositions and methods for delivering a substance to a biological target |
ES2547712T3 (es) | 2009-02-27 | 2015-10-08 | Genentech, Inc. | Métodos y composiciones para el marcado de proteínas |
US8691187B2 (en) | 2009-03-23 | 2014-04-08 | Eli Lilly And Company | Imaging agents for detecting neurological disorders |
JP2012521988A (ja) | 2009-03-23 | 2012-09-20 | シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド | 神経学的障害を検知するためのイメージング剤 |
AU2010260195B2 (en) | 2009-06-15 | 2014-11-20 | Molecular Insight Pharmaceuticals, Inc. | Process for production of heterodimers of glutamic acid |
JP6059533B2 (ja) * | 2009-11-09 | 2017-01-11 | ユニバーシティ オブ ワシントン センター フォー コマーシャライゼーション | 官能化発色性ポリマードットおよびその生物共役体 |
WO2012074840A2 (en) | 2010-11-22 | 2012-06-07 | The General Hospital Corporation | Compositions and methods for in vivo imaging |
EP2681196B1 (de) | 2011-03-04 | 2015-09-09 | Life Technologies Corporation | Verbindungen und verfahren zur konjugation von biomolekülen |
WO2012121746A2 (en) | 2011-03-09 | 2012-09-13 | The General Hospital Corporation | Imaging beta cell mass |
US10796494B2 (en) | 2011-06-06 | 2020-10-06 | Microsoft Technology Licensing, Llc | Adding attributes to virtual representations of real-world objects |
EP2800471A4 (de) | 2012-01-06 | 2015-11-04 | Molecular Insight Pharm Inc | Metallkomplexe von poly(carboxyl)aminhaltigen liganden mit einer affinität für carboanhydrase ix |
HUE040025T2 (hu) | 2012-08-24 | 2019-02-28 | Univ Texas | A HIF aktivitás heterociklusos modulátorai betegség kezelésére |
EP2888253A4 (de) * | 2012-08-24 | 2016-01-06 | Univ Texas | Heterocyclische hif-aktivitätsmodulatoren zur behandlung von krankheiten |
US9902705B2 (en) | 2012-10-24 | 2018-02-27 | The General Hospital Corporation | Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions |
EP3545978B1 (de) | 2013-01-14 | 2021-09-08 | Molecular Insight Pharmaceuticals, Inc. | Radiopharmazeutika auf triazinbasis und strahlungsbildgebungsmittel |
WO2014182704A2 (en) | 2013-05-06 | 2014-11-13 | The General Hospital Corporation | Bioorthogonal turn-on probes |
DK3110420T3 (da) | 2014-02-25 | 2019-05-13 | Board Of Regents Univ Of Texas System | Salte af heterocykliske modulatorer af hif-aktivitet til behandling af sygdomme |
US10731202B2 (en) | 2014-11-24 | 2020-08-04 | Battelle Memorial Institute | Chromatin activity precipitation method and system |
EP3870152A4 (de) * | 2018-10-24 | 2022-10-19 | APA- Advanced Technologies Ltd. | Fusogene liposomen zur selektiven bildgebung von tumorzellen |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3424525A1 (de) * | 1984-07-04 | 1986-01-16 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verfahren zur herstellung von (pfeil hoch)1(pfeil hoch)(pfeil hoch)8(pfeil hoch)f-alkyl- und arylverbindungen durch halogenaustausch |
US5519931A (en) * | 1994-03-16 | 1996-05-28 | Syncor International Corporation | Container and method for transporting a syringe containing radioactive material |
KR19990008328A (ko) * | 1995-05-01 | 1999-01-25 | 제롬 코크란 | 알쯔하이머 질환의 생전 진단 및 생체내 영상화 및 아밀로이드침착 예방을 위한 아조 화합물 |
US6210655B1 (en) * | 1997-06-18 | 2001-04-03 | University Of Medicine & Dentistry Of Nj | Site-specific 13C-enriched reagents for diagnostic medicine by magnetic resonance imaging |
US6558903B1 (en) * | 1999-06-30 | 2003-05-06 | Millennium Pharmaceuticals, Inc. | Kinases and uses thereof |
US20030190602A1 (en) * | 2001-03-12 | 2003-10-09 | Monogen, Inc. | Cell-based detection and differentiation of disease states |
US6808308B2 (en) * | 2001-05-25 | 2004-10-26 | Scanwell Systems | Removable shielding for use during neurological examinations on a whole body pet scanner |
WO2003081210A2 (en) * | 2002-03-21 | 2003-10-02 | Sunesis Pharmaceuticals, Inc. | Identification of kinase inhibitors |
ES2566761T3 (es) * | 2002-05-30 | 2016-04-15 | The Scripps Research Institute | Ligación de azidas y acetilenos catalizada por cobre |
US7149280B2 (en) | 2002-12-23 | 2006-12-12 | Astex Therapeutics Limited | Synthesis and screening of ligands using X-ray crystallography |
US20060067879A1 (en) * | 2004-09-27 | 2006-03-30 | Schuller Hildegard M | Diagnosis of diseases associated with COX-2 expression |
-
2006
- 2006-04-27 JP JP2008509206A patent/JP4790012B2/ja not_active Expired - Fee Related
- 2006-04-27 AT AT06751892T patent/ATE527542T1/de not_active IP Right Cessation
- 2006-04-27 EP EP06751892A patent/EP1875239B1/de not_active Not-in-force
- 2006-04-27 ES ES06751892T patent/ES2375495T3/es active Active
- 2006-04-27 KR KR1020077027109A patent/KR100973156B1/ko not_active IP Right Cessation
- 2006-04-27 WO PCT/US2006/016428 patent/WO2006116736A2/en active Application Filing
- 2006-04-27 US US11/413,967 patent/US20060269942A1/en not_active Abandoned
- 2006-04-27 CA CA2606477A patent/CA2606477C/en not_active Expired - Fee Related
- 2006-04-27 DK DK06751892.8T patent/DK1875239T3/da active
Also Published As
Publication number | Publication date |
---|---|
ES2375495T3 (es) | 2012-03-01 |
US20060269942A1 (en) | 2006-11-30 |
EP1875239B1 (de) | 2011-10-05 |
EP1875239A2 (de) | 2008-01-09 |
KR20080003441A (ko) | 2008-01-07 |
CA2606477A1 (en) | 2006-11-02 |
JP4790012B2 (ja) | 2011-10-12 |
CA2606477C (en) | 2013-05-28 |
JP2008541014A (ja) | 2008-11-20 |
WO2006116736A2 (en) | 2006-11-02 |
WO2006116736A3 (en) | 2007-02-01 |
KR100973156B1 (ko) | 2010-07-30 |
DK1875239T3 (da) | 2012-01-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |