ATE489478T1 - Nukleinsäuren, polypeptide und verfahren zur apoptosemodulation - Google Patents

Nukleinsäuren, polypeptide und verfahren zur apoptosemodulation

Info

Publication number
ATE489478T1
ATE489478T1 AT02759167T AT02759167T ATE489478T1 AT E489478 T1 ATE489478 T1 AT E489478T1 AT 02759167 T AT02759167 T AT 02759167T AT 02759167 T AT02759167 T AT 02759167T AT E489478 T1 ATE489478 T1 AT E489478T1
Authority
AT
Austria
Prior art keywords
apoptosis
polypeptides
nucleic acids
dhs
eif
Prior art date
Application number
AT02759167T
Other languages
English (en)
Inventor
Catherine Taylor
Tzann-Wei Wang
Larry Petrov
John Carlson
Richard Narayansingh
John Thompson
Dominic Cliche
Marianne Hopkins
Original Assignee
Senesco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/909,796 external-priority patent/US6867237B1/en
Application filed by Senesco Inc filed Critical Senesco Inc
Application granted granted Critical
Publication of ATE489478T1 publication Critical patent/ATE489478T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Analytical Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
AT02759167T 2001-07-23 2002-07-23 Nukleinsäuren, polypeptide und verfahren zur apoptosemodulation ATE489478T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/909,796 US6867237B1 (en) 2001-07-23 2001-07-23 DNA encoding apoptosis-induced eucaryotic initiation factor-5A and deoxyhypusine synthase and a method for controlling apoptosis in animals and humans
US10/141,647 US7166467B2 (en) 2001-07-23 2002-05-07 Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
PCT/US2002/023254 WO2003010286A2 (en) 2001-07-23 2002-07-23 Nucleic acids, polypeptides, and methods for modulating apoptosis

Publications (1)

Publication Number Publication Date
ATE489478T1 true ATE489478T1 (de) 2010-12-15

Family

ID=26839315

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02759167T ATE489478T1 (de) 2001-07-23 2002-07-23 Nukleinsäuren, polypeptide und verfahren zur apoptosemodulation

Country Status (12)

Country Link
US (3) US7166467B2 (de)
EP (1) EP1546375B1 (de)
JP (2) JP2005519583A (de)
KR (1) KR100944938B1 (de)
CN (1) CN100352923C (de)
AT (1) ATE489478T1 (de)
AU (1) AU2002324519B2 (de)
CA (2) CA2454822C (de)
DE (1) DE60238449D1 (de)
IL (1) IL159966A0 (de)
NZ (1) NZ531225A (de)
WO (1) WO2003010286A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166467B2 (en) * 2001-07-23 2007-01-23 Senesco Technologies, Inc. Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
US7968523B2 (en) 2001-07-23 2011-06-28 Senesco Technologies, Inc. Method for inducing apoptosis using apoptosis-specific EIF5-A
US7217517B2 (en) * 2001-07-23 2007-05-15 Senesco Technologies, Inc. Nucleic acids, polypeptides, and methods for modulating apoptosis
US7381708B2 (en) 2001-07-23 2008-06-03 Sensco Technologies, Inc. Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye
NZ542665A (en) * 2003-03-05 2008-05-30 Senesco Technologies Inc Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1
CN101014708B (zh) * 2003-03-05 2011-11-02 森尼斯科技术公司 反义寡核苷酸或siRNA在抑制eIF-5A1表达中的应用
NZ574973A (en) * 2003-06-06 2010-10-29 Senesco Technologies Inc Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics
US20140371299A1 (en) * 2004-06-07 2014-12-18 Senesco Technologies, Inc. Use of Apoptosis-Specific elF-5A siRNA to Down Regulate Expression of Proinflammatory Cytokines to Treat Sepsis
TW200615001A (en) * 2004-07-20 2006-05-16 Senesco Technologies Inc Use of apoptosis-specific eIF-5A siRNAs and antisense polynucleotides to inhibit/suppress an inflammatory response
WO2006060823A2 (en) * 2004-12-03 2006-06-08 Senesco Technologies, Inc. Apoptosis-specific eif-5a and polynucleotides encoding same
TWI441651B (zh) * 2005-12-13 2014-06-21 Senesco Technologies Inc ｅＩＦ-５Ａ於殺多發性骨髓瘤細胞之用途
EP1996707A2 (de) * 2006-03-20 2008-12-03 Senesco Technologies, Inc. Neuartiges verfahren zum schutz von inselzellen gegen apoptose während des donor-ernteverfahrens
AU2009223615B2 (en) 2008-03-07 2014-09-11 Senesco Technologies, Inc. Use of siRNA to achieve down regulation of an endogenous gene in combination with the use of a sense construct to achieve expression of a desired polynucleotide
WO2009144933A1 (ja) 2008-05-27 2009-12-03 国立大学法人東京大学 アポトーシス誘導薬
US8445638B2 (en) 2008-09-03 2013-05-21 Senesco Technologies, Inc. Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells
CN114231551B (zh) * 2021-12-24 2023-09-29 云南大学 蛋白在促进昆虫淋巴细胞凋亡和/或防治害虫中的应用

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2941668A1 (de) * 1979-10-15 1981-04-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München Kardiotachometer
CA1199371A (en) * 1982-12-03 1986-01-14 Orest Z. Roy Ultrasonic enhancement of cardiac contractility synchronised with ecg event or defibrillation pulse
US4936304A (en) * 1985-10-07 1990-06-26 Thomas Jefferson University Pacing system and method for cardiac pacing as a function of determined myocardial contractility
US5527336A (en) * 1986-12-09 1996-06-18 Boston Scientific Corporation Flow obstruction treatment method
US4881549A (en) * 1987-05-29 1989-11-21 Marquette Electronics Apparatus and method for obtaining ultrasonic backcatter measurement from tissue
GB8717430D0 (en) * 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
CA1327838C (fr) * 1988-06-13 1994-03-15 Fred Zacouto Dispositif implantable de protection contre les affections liees a la coagulation sanguine
US4917115A (en) * 1988-07-11 1990-04-17 Vitatron Medical B. V. Pacing system and method for physiological stimulation of the heart utilizing Doppler means
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5220924A (en) * 1989-09-28 1993-06-22 Frazin Leon J Doppler-guided retrograde catheterization using transducer equipped guide wire
US5168064A (en) * 1990-04-20 1992-12-01 The Regents Of The University Of California Endo-1,4-β-glucanase gene and its use in plants
DE69122015T2 (de) * 1990-09-11 1997-04-17 Breyer Branco Herzelektrotherapiesystem
US5188106A (en) * 1991-03-08 1993-02-23 Telectronics Pacing Systems, Inc. Method and apparatus for chronically monitoring the hemodynamic state of a patient using doppler ultrasound
US5183040A (en) * 1991-03-08 1993-02-02 Telectronics Pacing Systems, Inc. Apparatus and method for detecting abnormal cardiac rhythms using an ultrasound sensor in an arrhythmia control system
US5156157A (en) * 1991-03-08 1992-10-20 Telectronics Pacing Systems, Inc. Catheter-mounted doppler ultrasound transducer and signal processor
US5139020A (en) * 1991-03-08 1992-08-18 Telectronics Pacing Systems, Inc. Method and apparatus for controlling the hemodynamic state of a patient based on systolic time interval measurements detecting using doppler ultrasound techniques
US5156154A (en) * 1991-03-08 1992-10-20 Telectronics Pacing Systems, Inc. Monitoring the hemodynamic state of a patient from measurements of myocardial contractility using doppler ultrasound techniques
JPH05233318A (ja) * 1992-02-18 1993-09-10 Nec Corp マイクロプロセッサ
US5197467A (en) * 1992-06-22 1993-03-30 Telectronics Pacing Systems, Inc. Multiple parameter rate-responsive cardiac stimulation apparatus
US5508045A (en) * 1992-10-09 1996-04-16 The Regents Of The University Of California Method and agents for control and management of labor during pregnancy
US5830848A (en) * 1992-10-09 1998-11-03 The Regents Of The University Of California Method and agents for inducement of endogenous nitric oxide synthase for control and management of labor during pregnancy
US5344846A (en) * 1992-12-30 1994-09-06 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for inhibiting deoxyhypusine synthase and the growth of cells
US5738096A (en) * 1993-07-20 1998-04-14 Biosense, Inc. Cardiac electromechanics
US5609612A (en) * 1993-10-05 1997-03-11 Sorin Biomedica Cardio S.P.A. Device for determining myocardial function and corresponding procedure and method
US5865738A (en) * 1993-12-10 1999-02-02 Regents Of The University Of California Tissue viability monitor
US5686649A (en) 1994-03-22 1997-11-11 The Rockefeller University Suppression of plant gene expression using processing-defective RNA constructs
US5546949A (en) * 1994-04-26 1996-08-20 Frazin; Leon Method and apparatus of logicalizing and determining orientation of an insertion end of a probe within a biotic structure
US5722419A (en) * 1994-11-30 1998-03-03 Semmlow; John L. System for determining the viability of tissue
US5544656A (en) * 1994-12-02 1996-08-13 The Regents Of The University Of California Method and apparatus for myocardial wall measurement
CZ255397A3 (cs) 1995-02-13 1998-02-18 Novartis Ag Mutantní proteiny, způsob jejich přípravy, farmaceutické prostředky, které je obsahují, a jejich použití
US6020139A (en) * 1995-04-25 2000-02-01 Oridigm Corporation S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy
US5849587A (en) * 1995-06-09 1998-12-15 Cornell Research Foundation, Inc. Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells
US5727552A (en) * 1996-01-11 1998-03-17 Medtronic, Inc. Catheter and electrical lead location system
US5948771A (en) * 1996-01-31 1999-09-07 The Trustees Of Columbia University In The City Of New York Method for treating heart failure using tetrapyrroles and metallotetrapyrroles
US6214572B1 (en) * 1996-08-09 2001-04-10 The General Hospital Corporation Programmed cell death and ICH-3
US6024703A (en) * 1997-05-07 2000-02-15 Eclipse Surgical Technologies, Inc. Ultrasound device for axial ranging
US6124091A (en) * 1997-05-30 2000-09-26 Research Corporation Technologies, Inc. Cell growth-controlling oligonucleotides
US5749831A (en) * 1997-06-23 1998-05-12 Baker; Donald A. Fetal cardiac monitoring utilizing umbilical blood flow parameters and heartbeat information
EP1002079A2 (de) 1997-06-30 2000-05-24 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Zellwachstumshemmer
US5792199A (en) * 1997-07-24 1998-08-11 Pacesetter, Inc. Pacemaker having rate responsive transducer and method for operating same
US6490474B1 (en) * 1997-08-01 2002-12-03 Cardiac Pathways Corporation System and method for electrode localization using ultrasound
SE9702876D0 (sv) * 1997-08-06 1997-08-06 Pacesetter Ab A cardiac monitoring device and rate responsive pacemaker system
US5836985A (en) * 1997-09-18 1998-11-17 The Regents Of The University Of Michigan Method for treating abnormal arial or ventricular activity
US5991660A (en) * 1997-09-18 1999-11-23 The Regents Of The University Of Michigan Cardiac pacing methods
US6277077B1 (en) * 1998-11-16 2001-08-21 Cardiac Pathways Corporation Catheter including ultrasound transducer with emissions attenuation
US6398736B1 (en) * 1999-03-31 2002-06-04 Mayo Foundation For Medical Education And Research Parametric imaging ultrasound catheter
US6298269B1 (en) * 1999-04-19 2001-10-02 Cardiac Pacemakers, Inc. Cardiac rhythm management system with ultrasound for autocapture or other applications
US6538182B1 (en) * 1999-07-06 2003-03-25 Senesco, Inc. DNA encoding a plant deoxyhypusine synthase, a plant eukaryotic initiation factor 5A, transgenic plants and a method for controlling senescence programmed and cell death in plants
EP1200468A1 (de) 1999-08-06 2002-05-02 PHARMACIA & UPJOHN COMPANY Kristallisation und strukturbestimmung von staphylococcus aureus elongationsfaktor p
US6443894B1 (en) * 1999-09-29 2002-09-03 Acuson Corporation Medical diagnostic ultrasound system and method for mapping surface data for three dimensional imaging
US6491639B1 (en) * 1999-11-10 2002-12-10 Pacesetter, Inc. Extravascular hemodynamic sensor
US6450977B1 (en) * 2000-04-10 2002-09-17 Cervilenz Devices and methods for cervix measurement
US7968523B2 (en) * 2001-07-23 2011-06-28 Senesco Technologies, Inc. Method for inducing apoptosis using apoptosis-specific EIF5-A
US7217517B2 (en) * 2001-07-23 2007-05-15 Senesco Technologies, Inc. Nucleic acids, polypeptides, and methods for modulating apoptosis
US7166467B2 (en) * 2001-07-23 2007-01-23 Senesco Technologies, Inc. Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
US7381708B2 (en) * 2001-07-23 2008-06-03 Sensco Technologies, Inc. Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye

Also Published As

Publication number Publication date
DE60238449D1 (de) 2011-01-05
CA2454822C (en) 2014-09-23
AU2002324519B2 (en) 2008-05-15
WO2003010286A2 (en) 2003-02-06
IL159966A0 (en) 2004-06-20
US20030064952A1 (en) 2003-04-03
US7166467B2 (en) 2007-01-23
US20120064625A1 (en) 2012-03-15
JP2011103892A (ja) 2011-06-02
CA2454822A1 (en) 2003-02-06
WO2003010286A3 (en) 2005-05-06
EP1546375A2 (de) 2005-06-29
AU2002324519A2 (en) 2003-02-17
CN100352923C (zh) 2007-12-05
EP1546375B1 (de) 2010-11-24
US20070059831A1 (en) 2007-03-15
CN1636064A (zh) 2005-07-06
NZ531225A (en) 2008-04-30
JP2005519583A (ja) 2005-07-07
EP1546375A4 (de) 2006-11-08
WO2003010286A9 (en) 2003-12-31
CA2857312A1 (en) 2003-02-06
US7872112B2 (en) 2011-01-18
KR100944938B1 (ko) 2010-03-02
KR20040014670A (ko) 2004-02-14

Similar Documents

Publication Publication Date Title
ATE489478T1 (de) Nukleinsäuren, polypeptide und verfahren zur apoptosemodulation
DE60319369D1 (de) Nukleinsäuren, polypeptide und verfahren zur modulierung von apoptosis
ATE544473T1 (de) Chimäre moleküle zur modulation der genexpression
DE69723074D1 (de) Mch4 und mch5, apoptotische proteasen, dafür kodierende nukleinsäure und verfahren zur verwendung
DE69935085D1 (de) Verfahren und Zusammensetzung zur Hemmung des neoplastischen Zellwachstums
DE69840966D1 (de) Homolog NL6 des Tie Rezeptor Tyrosinekinase Liganden
DE69533564D1 (de) Effektor-Proteine für Rapamycin
DE69434614D1 (de) Cdn apoptosis modulierende proteine, sie kodierende dns und verfahren zu ihrer verwendung
IL130036A0 (en) Survivin a protein that inhibits cellular apoptosis and its modulation
DE69835143D1 (de) Selektion von proteinen mittels rns-protein fusionen
DK1675956T3 (da) Minimal DNA-sekvens, der virksom som chromatinisolator, og dennes anvendelse til proteinekspression
DE50012831D1 (de) Verfahren zur verbindung von molekularen substanzen
DE69831007D1 (de) Humane checkpointkinase, hcds1, zusammensetzungen und verfahren
DE602004032345D1 (de) Reagenzien und verfahren zur bildung von disulfid-bindungen und glykosylierung von proteinen
ATE408029T1 (de) Verfahren zur herstellung und identifizierung löslicher proteindomänen
DK1255829T3 (da) Inhibitor af hepatocytvækstfaktoraktivator til anvendelse i modulation af angiogenese og kardiovaskularisering
ATE278702T1 (de) Verfahren zur synthese von phosphorothioat- oligonukelotiden
DE69827268D1 (de) Verfahren und zusammensetzungen zur raschen aufreinigung von proteasomen und verfahren zur verwendung entsprechender komponenten
IL157309A0 (en) Method for the purification of a non-immunoglobulin protein
DK1078072T3 (da) Nye peptidfragmenter til oprensning af proteiner
ATE435914T1 (de) Induktion der blütenbildung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties