ATE489478T1 - Nukleinsäuren, polypeptide und verfahren zur apoptosemodulation - Google Patents

Nukleinsäuren, polypeptide und verfahren zur apoptosemodulation

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Publication number
ATE489478T1
ATE489478T1 AT02759167T AT02759167T ATE489478T1 AT E489478 T1 ATE489478 T1 AT E489478T1 AT 02759167 T AT02759167 T AT 02759167T AT 02759167 T AT02759167 T AT 02759167T AT E489478 T1 ATE489478 T1 AT E489478T1
Authority
AT
Austria
Prior art keywords
apoptosis
polypeptides
nucleic acids
dhs
eif
Prior art date
Application number
AT02759167T
Other languages
English (en)
Inventor
Catherine Taylor
Tzann-Wei Wang
Larry Petrov
John Carlson
Richard Narayansingh
John Thompson
Dominic Cliche
Marianne Hopkins
Original Assignee
Senesco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/909,796 external-priority patent/US6867237B1/en
Application filed by Senesco Inc filed Critical Senesco Inc
Application granted granted Critical
Publication of ATE489478T1 publication Critical patent/ATE489478T1/de

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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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AT02759167T 2001-07-23 2002-07-23 Nukleinsäuren, polypeptide und verfahren zur apoptosemodulation ATE489478T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/909,796 US6867237B1 (en) 2001-07-23 2001-07-23 DNA encoding apoptosis-induced eucaryotic initiation factor-5A and deoxyhypusine synthase and a method for controlling apoptosis in animals and humans
US10/141,647 US7166467B2 (en) 2001-07-23 2002-05-07 Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
PCT/US2002/023254 WO2003010286A2 (en) 2001-07-23 2002-07-23 Nucleic acids, polypeptides, and methods for modulating apoptosis

Publications (1)

Publication Number Publication Date
ATE489478T1 true ATE489478T1 (de) 2010-12-15

Family

ID=26839315

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02759167T ATE489478T1 (de) 2001-07-23 2002-07-23 Nukleinsäuren, polypeptide und verfahren zur apoptosemodulation

Country Status (12)

Country Link
US (3) US7166467B2 (de)
EP (1) EP1546375B1 (de)
JP (2) JP2005519583A (de)
KR (1) KR100944938B1 (de)
CN (1) CN100352923C (de)
AT (1) ATE489478T1 (de)
AU (1) AU2002324519B2 (de)
CA (2) CA2857312A1 (de)
DE (1) DE60238449D1 (de)
IL (1) IL159966A0 (de)
NZ (1) NZ531225A (de)
WO (1) WO2003010286A2 (de)

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US7381708B2 (en) 2001-07-23 2008-06-03 Sensco Technologies, Inc. Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye
US7166467B2 (en) * 2001-07-23 2007-01-23 Senesco Technologies, Inc. Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
US7968523B2 (en) 2001-07-23 2011-06-28 Senesco Technologies, Inc. Method for inducing apoptosis using apoptosis-specific EIF5-A
CN101014708B (zh) * 2003-03-05 2011-11-02 森尼斯科技术公司 反义寡核苷酸或siRNA在抑制eIF-5A1表达中的应用
KR20050098954A (ko) * 2003-03-05 2005-10-12 세네스코 테크놀로지스 인코포레이티드 이아이에프-5에이1의 발현을 억제하기 위한 안티센스올리고뉴클레오타이드 또는 에스아이알엔에이의 이용
NZ544159A (en) * 2003-06-06 2009-04-30 Senesco Technologies Inc Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics
US20140371299A1 (en) * 2004-06-07 2014-12-18 Senesco Technologies, Inc. Use of Apoptosis-Specific elF-5A siRNA to Down Regulate Expression of Proinflammatory Cytokines to Treat Sepsis
EP1769075A2 (de) * 2004-07-20 2007-04-04 Senesco Technologies, Inc. Verwendung von apoptosis spezifischen eif-5a sirnas und antisense polynukleotiden zur verhinderung/unterdrückung von entzündlichen prozessen
TW200634154A (en) * 2004-12-03 2006-10-01 Senesco Technologies Inc Apoptosis-specific EIF-5A and polynucleotides encoding same
WO2007070824A2 (en) * 2005-12-13 2007-06-21 Senesco Technologies, Inc. Use of eif-5a to kill multiple myeloma cells
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US8703929B2 (en) 2008-03-07 2014-04-22 Senesco Technologies, Inc. Compositions comprising siRNA and plasmids
US8492521B2 (en) 2008-05-27 2013-07-23 Yoshinori Seko Oxidative stress responsive apoptosis inducing protein eIF5A
US8445638B2 (en) 2008-09-03 2013-05-21 Senesco Technologies, Inc. Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells
CN114231551B (zh) * 2021-12-24 2023-09-29 云南大学 蛋白在促进昆虫淋巴细胞凋亡和/或防治害虫中的应用

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KR20040014670A (ko) 2004-02-14
CN100352923C (zh) 2007-12-05
WO2003010286A3 (en) 2005-05-06
US20030064952A1 (en) 2003-04-03
EP1546375B1 (de) 2010-11-24
JP2005519583A (ja) 2005-07-07
IL159966A0 (en) 2004-06-20
WO2003010286A9 (en) 2003-12-31
AU2002324519A2 (en) 2003-02-17
CA2454822A1 (en) 2003-02-06
EP1546375A2 (de) 2005-06-29
NZ531225A (en) 2008-04-30
AU2002324519B2 (en) 2008-05-15
JP2011103892A (ja) 2011-06-02
WO2003010286A2 (en) 2003-02-06
DE60238449D1 (de) 2011-01-05
US20120064625A1 (en) 2012-03-15
EP1546375A4 (de) 2006-11-08
CA2857312A1 (en) 2003-02-06
KR100944938B1 (ko) 2010-03-02
CN1636064A (zh) 2005-07-06
US7872112B2 (en) 2011-01-18
CA2454822C (en) 2014-09-23
US7166467B2 (en) 2007-01-23

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