ATE314482T1 - Rekombinante adenoviren-vektor und verfahren zur verwendung - Google Patents

Rekombinante adenoviren-vektor und verfahren zur verwendung

Info

Publication number
ATE314482T1
ATE314482T1 AT95900422T AT95900422T ATE314482T1 AT E314482 T1 ATE314482 T1 AT E314482T1 AT 95900422 T AT95900422 T AT 95900422T AT 95900422 T AT95900422 T AT 95900422T AT E314482 T1 ATE314482 T1 AT E314482T1
Authority
AT
Austria
Prior art keywords
recombinant adenovirus
adenovirus vector
vector
protein
dna
Prior art date
Application number
AT95900422T
Other languages
English (en)
Inventor
Richard J Gregory
Ken N Wills
Daniel C Maneval
Original Assignee
Canji Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Canji Inc filed Critical Canji Inc
Application granted granted Critical
Publication of ATE314482T1 publication Critical patent/ATE314482T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/008Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/80Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT95900422T 1993-10-25 1994-10-25 Rekombinante adenoviren-vektor und verfahren zur verwendung ATE314482T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14266993A 1993-10-25 1993-10-25
US24600694A 1994-05-19 1994-05-19
PCT/US1994/012235 WO1995011984A2 (en) 1993-10-25 1994-10-25 Recombinant adenoviral vector and methods of use

Publications (1)

Publication Number Publication Date
ATE314482T1 true ATE314482T1 (de) 2006-01-15

Family

ID=26840311

Family Applications (2)

Application Number Title Priority Date Filing Date
AT95900422T ATE314482T1 (de) 1993-10-25 1994-10-25 Rekombinante adenoviren-vektor und verfahren zur verwendung
AT05020924T ATE437232T1 (de) 1993-10-25 1994-10-25 Rekombinanter adenoviren-vektor und verfahren zur verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT05020924T ATE437232T1 (de) 1993-10-25 1994-10-25 Rekombinanter adenoviren-vektor und verfahren zur verwendung

Country Status (21)

Country Link
US (5) US20080182807A1 (de)
EP (3) EP0797676B9 (de)
JP (1) JP3875990B2 (de)
CN (1) CN1263864C (de)
AT (2) ATE314482T1 (de)
AU (1) AU687117B2 (de)
BR (1) BR9407956A (de)
CA (1) CA2173975C (de)
CZ (1) CZ291372B6 (de)
DE (2) DE69435223D1 (de)
DK (1) DK0797676T3 (de)
ES (2) ES2256842T4 (de)
FI (1) FI961755A7 (de)
HU (1) HU223733B1 (de)
NO (1) NO961639L (de)
NZ (1) NZ275956A (de)
PL (1) PL186073B1 (de)
PT (1) PT797676E (de)
RU (1) RU2162342C2 (de)
SK (1) SK283703B6 (de)
WO (1) WO1995011984A2 (de)

Families Citing this family (404)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747469A (en) 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
AU663702B2 (en) 1991-03-06 1995-10-19 Board Of Regents, The University Of Texas System Methods and compositions for the selective inhibition of gene expression
US6410010B1 (en) * 1992-10-13 2002-06-25 Board Of Regents, The University Of Texas System Recombinant P53 adenovirus compositions
ATE314482T1 (de) * 1993-10-25 2006-01-15 Canji Inc Rekombinante adenoviren-vektor und verfahren zur verwendung
US5698443A (en) * 1995-06-27 1997-12-16 Calydon, Inc. Tissue specific viral vectors
US5998205A (en) 1994-11-28 1999-12-07 Genetic Therapy, Inc. Vectors for tissue-specific replication
JPH10509879A (ja) * 1994-11-28 1998-09-29 ジェネティック セラピー, インコーポレイテッド 複製欠陥ベクターを用いる、組織特異的処置、診断方法、および組成物
US6638762B1 (en) 1994-11-28 2003-10-28 Genetic Therapy, Inc. Tissue-vectors specific replication and gene expression
JP3827163B2 (ja) * 1995-03-24 2006-09-27 ジェンザイム・コーポレーション 遺伝子治療用のアデノウイルスベクター
US5707618A (en) * 1995-03-24 1998-01-13 Genzyme Corporation Adenovirus vectors for gene therapy
US20030026789A1 (en) * 1995-05-03 2003-02-06 Richard J. Gregory Gene therapy using replication competent targeted adenoviral vectors
US6254862B1 (en) 1997-03-03 2001-07-03 Calydon, Inc. Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof
US6197293B1 (en) 1997-03-03 2001-03-06 Calydon, Inc. Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof
US7011976B1 (en) 1997-03-03 2006-03-14 Calydon, Inc. Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof
US6676935B2 (en) 1995-06-27 2004-01-13 Cell Genesys, Inc. Tissue specific adenoviral vectors
US5801030A (en) * 1995-09-01 1998-09-01 Genvec, Inc. Methods and vectors for site-specific recombination
US6392069B2 (en) 1996-01-08 2002-05-21 Canji, Inc. Compositions for enhancing delivery of nucleic acids to cells
US7002027B1 (en) 1996-01-08 2006-02-21 Canji, Inc. Compositions and methods for therapeutic use
US5789244A (en) * 1996-01-08 1998-08-04 Canji, Inc. Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems
US6132989A (en) * 1996-06-03 2000-10-17 University Of Washington Methods and compositions for enhanced stability of non-adenoviral DNA
US5869037A (en) * 1996-06-26 1999-02-09 Cornell Research Foundation, Inc. Adenoviral-mediated gene transfer to adipocytes
US7232899B2 (en) 1996-09-25 2007-06-19 The Scripps Research Institute Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use
NZ508399A (en) * 1996-09-25 2003-06-30 Novartis Ag Packaging cell lines for use in facilitating the development of high capacity adenoviral vectors
KR20000049243A (ko) * 1996-10-18 2000-07-25 이. 엘. 나가부샨, 리차드 비. 머피 인터페론-알파 핵산의 운반 및 발현 방법 및 이를 위한 조성물
US6544523B1 (en) 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
IL130009A0 (en) * 1996-11-18 2000-02-29 Univ Mcgill Post-mitotic neurons containing adenovirus vectors that modulate apoptosis and growth
US6544769B1 (en) 1996-12-13 2003-04-08 Schering Corporation Compostions comprising viruses and methods for concentrating virus preparations
WO1998026048A1 (en) 1996-12-13 1998-06-18 Schering Corporation Methods for purifying viruses
US6261823B1 (en) 1996-12-13 2001-07-17 Schering Corporation Methods for purifying viruses
WO1998032860A1 (en) * 1997-01-28 1998-07-30 Baxter International Inc. Methods for highly efficient generation of adenoviral vectors
US6168944B1 (en) 1997-01-31 2001-01-02 Schering Corporation Methods for cultivating cells and propagating viruses
US6146891A (en) * 1997-01-31 2000-11-14 Schering Corporation Methods for cultivating cells and propagating viruses
US6403370B1 (en) 1997-02-10 2002-06-11 Genstar Therapeutics Corporation Oncolytic/immunogenic complementary-adenoviral vector system
US20030060434A1 (en) 1997-02-18 2003-03-27 Loretta Nielsen Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
US6200799B1 (en) * 1997-06-03 2001-03-13 University Of Lausanne Somatic gene therapy to suppress secondary cataract formation following eye surgery
AU9363798A (en) 1997-11-06 1999-05-31 Chiron S.P.A. Neisserial antigens
CA2317815A1 (en) 1998-01-14 1999-07-22 Chiron S.P.A. Neisseria meningitidis antigens
IL137510A0 (en) 1998-02-17 2001-07-24 Schering Corp Compositions comprising viruses and methods for concentrating virus preparations
PT1944371E (pt) 1998-05-01 2015-07-13 Novartis Ag Antigénios e composições da neisseria meningitidis
WO2001031019A2 (en) 1999-10-29 2001-05-03 Chiron Spa Neisserial antigenic peptides
AU3883299A (en) * 1998-05-12 1999-11-29 Baylor College Of Medicine Cancer prevention by selective delivery methods
US6900049B2 (en) 1998-09-10 2005-05-31 Cell Genesys, Inc. Adenovirus vectors containing cell status-specific response elements and methods of use thereof
US6649158B1 (en) 1998-10-15 2003-11-18 Canji, Inc. Methods and compositions to induce antitumor response
WO2000022124A2 (en) * 1998-10-15 2000-04-20 Canji, Inc. Methods and compositions to induce antitumor response
AU2145300A (en) * 1998-11-18 2000-06-05 Canji, Inc. Adenoviral vectors
US6495130B1 (en) 1998-12-30 2002-12-17 Calydon, Inc. Target cell-specific adenoviral vectors containing E3 and methods of use thereof
US7625859B1 (en) 2000-02-16 2009-12-01 Oregon Health & Science University HER-2 binding antagonists
EP2290083B1 (de) 1999-04-30 2014-08-20 Novartis Vaccines and Diagnostics S.r.l. Konservierte Antigene aus Neisseria
GB9911683D0 (en) 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
GB9916529D0 (en) 1999-07-14 1999-09-15 Chiron Spa Antigenic peptides
EP1232264B1 (de) 1999-11-18 2009-10-21 Novartis Vaccines and Diagnostics, Inc. Menschliches fgf-21 gen und genexpressionsprodukte
JP2003520248A (ja) 2000-01-17 2003-07-02 カイロン エセ.ピー.アー. N.meningitidis血清型b外膜タンパク質を含む外膜小胞(omv)ワクチン
EP1854476A3 (de) 2000-02-09 2008-05-07 Bas Medical, Inc. Verwendung von Relaxin zur Behandlung von durch Vasokonstriktion bedingten Krankheiten
EP2075255A1 (de) 2000-03-08 2009-07-01 Novartis Vaccines and Diagnostics, Inc. Menschliche FGF-23-Gene und Genexpressionsprodukte
WO2001090392A1 (en) 2000-05-26 2001-11-29 Sumitomo Pharmaceuticals Company, Limited Novel recombinant adenovirus vector with relieved side effects
US7700359B2 (en) 2000-06-02 2010-04-20 Novartis Vaccines And Diagnostics, Inc. Gene products differentially expressed in cancerous cells
EP1953243B1 (de) 2000-06-15 2012-12-26 Novartis Vaccines and Diagnostics, Inc. Polynukleotide im Zusammenhang mit Darmkrebs
DE10045687B4 (de) * 2000-09-15 2006-07-06 MICROMUN Privates Institut für Mikrobiologische Forschung GmbH Biotechnikum Greifswald Expressionskassetten und Adenovirusvektoren
NZ594877A (en) 2000-10-27 2012-07-27 Novartis Vaccines & Diagnostic Nucleic acids and proteins from streptococcus groups A & B
WO2002046477A2 (en) 2000-12-07 2002-06-13 Chiron Corporation Endogenous retroviruses up-regulated in prostate cancer
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
WO2002081641A2 (en) 2001-04-06 2002-10-17 Georgetown University Gene scc-112 and diagnostic and therapeutic uses thereof
WO2002081639A2 (en) 2001-04-06 2002-10-17 Georgetown University Gene brcc2 and diagnostic and therapeutic uses thereof
WO2002081642A2 (en) 2001-04-06 2002-10-17 Georgetown University Gene brcc-3 and diagnostic and therapeutic uses thereof
CN100398551C (zh) 2001-11-09 2008-07-02 乔治敦大学 新的血管内皮细胞生长抑制剂同种型
EP2335723A1 (de) 2001-12-12 2011-06-22 Novartis Vaccines and Diagnostics S.r.l. Immunisierung gegen Chlamydia trachomatis
AU2003235791A1 (en) 2002-01-08 2003-07-24 Chiron Corporation Gene products differentially expressed in cancerous breast cells and their methods of use
NZ535754A (en) 2002-03-15 2007-01-26 Wyeth Corp Mutants of the P4 protein of nontypable haemophilus influenzae with reduced enzymatic activity
EP2093233A1 (de) 2002-03-21 2009-08-26 Sagres Discovery, Inc. Neue Zusammensetzungen und Verfahren bei Krebs
US7244565B2 (en) 2002-04-10 2007-07-17 Georgetown University Gene shinc-3 and diagnostic and therapeutic uses thereof
US7138512B2 (en) 2002-04-10 2006-11-21 Georgetown University Gene SHINC-2 and diagnostic and therapeutic uses thereof
ATE545651T1 (de) 2002-06-13 2012-03-15 Novartis Vaccines & Diagnostic Vektoren zur expression von hml-2-polypeptiden
AU2003243307B2 (en) * 2002-06-21 2010-04-01 Wellstat Biologics Corporation Administration of therapeutic viruses
US7252822B2 (en) 2002-10-08 2007-08-07 Rinat Neuroscience Corp. Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist
WO2005000194A2 (en) 2002-10-08 2005-01-06 Rinat Neuroscience Corp. Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same
UA80447C2 (en) 2002-10-08 2007-09-25 Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic
US9498530B2 (en) 2002-12-24 2016-11-22 Rinat Neuroscience Corp. Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
EP3539569A1 (de) 2002-12-24 2019-09-18 Rinat Neuroscience Corp. Anti-ngf antikörper und verfahren zu ihrer verwendung in der behandlung von schmerz, der mit krankheiten des bewegungsapparats assoziiert ist
US7569364B2 (en) 2002-12-24 2009-08-04 Pfizer Inc. Anti-NGF antibodies and methods using same
US7767387B2 (en) 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
JP2007524362A (ja) 2003-02-14 2007-08-30 サイグレス ディスカバリー, インコーポレイテッド 癌における治療gpcr標的
WO2004073653A2 (en) 2003-02-19 2004-09-02 Rinat Neuroscience Corp. Methods for treating pain by administering a nerve growth factor antagonist and an nsaid and compositions containing the same
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
US8052966B2 (en) 2003-04-21 2011-11-08 University Of Southern California Methods and compositions for treating metastatic cancer
CN1845932A (zh) 2003-06-04 2006-10-11 坎基股份有限公司 转染剂
JP4809061B2 (ja) * 2003-11-21 2011-11-02 第一三共株式会社 心筋細胞の増殖方法
AP2006003670A0 (en) 2003-12-23 2006-06-30 Rinat Neuroscience Corp Agonist anti-TRKC antibodies and methods using same
WO2005093064A1 (ja) 2004-03-29 2005-10-06 Galpharma Co., Ltd. 新規ガレクチン9改変体タンパク質及びその用途
NZ549990A (en) 2004-04-07 2009-08-28 Rinat Neuroscience Copr Methods for treating bone cancer pain by administering a nerve growth factor antagonist
EP1789593B1 (de) 2004-07-09 2017-03-15 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Lösliche formen von hendra-virus-g-glycoprotein
US20060024677A1 (en) 2004-07-20 2006-02-02 Morris David W Novel therapeutic targets in cancer
AU2005290250A1 (en) 2004-07-30 2006-04-06 Rinat Neuroscience Corp. Antibodies directed against amyloid-beta peptide and methods using same
CA2577125C (en) 2004-10-07 2016-01-12 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
SG164344A1 (en) 2005-02-18 2010-09-29 Novartis Vaccines & Diagnostics Srl Immunogens from uropathogenic escherichia coli
EP2062591A1 (de) 2005-04-07 2009-05-27 Novartis Vaccines and Diagnostics, Inc. CACNA1E in der Krebsdiagnose-Erkennung und -Behandlung
AU2006235258A1 (en) 2005-04-07 2006-10-19 Novartis Vaccines And Diagnostics Inc. Cancer-related genes
DK1879623T3 (da) 2005-05-02 2012-12-17 Genzyme Corp Genterapi til rygmarvssygdomme
ES2887076T3 (es) 2005-05-02 2021-12-21 Genzyme Corp Terapia génica para trastornos neurometabólicos
CA2615615A1 (en) 2005-07-22 2007-02-01 Y's Therapeutics Co., Ltd. Anti-cd26 antibodies and methods of use thereof
EP1957106B2 (de) 2005-11-14 2019-07-24 Teva Pharmaceuticals International GmbH Antagonisten-antikörper gegen calcitonin-gen-related-peptid und verfahren damit
US7935342B2 (en) 2006-02-02 2011-05-03 Rinat Neuroscience Corp. Methods for treating obesity by administering a trkB antagonist
HUE041928T2 (hu) 2006-02-08 2019-06-28 Genzyme Corp Génterápia A-típusú Niemann-Pick-betegségre
JP2009539847A (ja) 2006-06-07 2009-11-19 ジェンザイム・コーポレーション 筋萎縮性側索硬化症および他の脊髄障害のための遺伝子治療
HUE043255T2 (hu) 2006-06-07 2019-08-28 Bioalliance Cv Antitestek, amelyek felismernek ráksejteken expresszált CD43-on és CEA-n jelenlévõ, szénhidrátot tartalmazó epitópot, és eljárások alkalmazásukra
US20100015168A1 (en) 2006-06-09 2010-01-21 Novartis Ag Immunogenic compositions for streptococcus agalactiae
US20100166788A1 (en) 2006-08-16 2010-07-01 Novartis Vaccines And Diagnostics Immunogens from uropathogenic escherichia coli
SI2497500T1 (sl) 2006-10-03 2017-01-31 Genzyme Corporation Genska terapija za spinalno mišično atrofijo
WO2008124176A2 (en) 2007-04-10 2008-10-16 The Administrators Of The Tulane Educational Fund Soluble and membrane-anchored forms of lassa virus subunit proteins
BR122019000505B1 (pt) 2007-05-11 2022-01-18 Alexion Pharmaceuticals, Inc Fosfatase alcalina direcionada ao osso, kits e métodos de seu uso
CN104383556B (zh) 2007-05-16 2018-06-05 布里格姆妇女医院 突触核蛋白病的治疗
ES2635726T3 (es) 2007-06-06 2017-10-04 Genzyme Corporation Terapia génica para enfermedades de almacenamiento lisosómico
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
CN102335424B (zh) * 2007-08-22 2013-12-04 中国人民解放军军事医学科学院军事兽医研究所 利用ix蛋白展示狂犬病病毒保护性抗原的犬ii型腺病毒活载体重组疫苗
KR102069498B1 (ko) 2007-09-28 2020-01-23 포톨라 파마슈티컬스, 인코포레이티드 인자 Xa 저해제에 대한 안티도트 및 그것을 사용하는 방법
CA2704232C (en) 2007-11-08 2017-05-02 Dana-Farber Cancer Institute, Inc. Stimulation of anti-tumor immunity using dendritic cell/tumor cell fusions and anti-cd3/cd28
AU2008337100B2 (en) 2007-12-17 2013-02-28 Pfizer Limited Treatment of interstitial cystitis
JP5568478B2 (ja) 2007-12-18 2014-08-06 バイオアライアンス セー.フェー. 癌細胞で発現するcd−43およびceaの炭水化物含有エピトープを認識する抗体およびそれを使用する方法
WO2009126306A2 (en) 2008-04-10 2009-10-15 Cell Signaling Technology, Inc. Compositions and methods for detecting egfr mutations in cancer
WO2009150623A1 (en) 2008-06-13 2009-12-17 Pfizer Inc Treatment of chronic prostatitis
TWI445716B (zh) 2008-09-12 2014-07-21 Rinat Neuroscience Corp Pcsk9拮抗劑類
US20100180082A1 (en) * 2009-01-12 2010-07-15 Viasat, Inc. Methods and systems for implementing url masking
WO2010086828A2 (en) 2009-02-02 2010-08-05 Rinat Neuroscience Corporation Agonist anti-trkb monoclonal antibodies
ES2733084T3 (es) 2009-03-06 2019-11-27 Glaxosmithkline Biologicals Sa Antígenos de Chlamydia
CN102439136A (zh) 2009-03-26 2012-05-02 加州大学校董 产生用于疾病修饰的抑制性rna的间充质干细胞
PL3604510T3 (pl) 2009-03-30 2025-07-28 Alexion Pharmaceuticals, Inc. Antidota na inhibitory czynnika xa i sposoby ich stosowania
WO2010118243A2 (en) 2009-04-08 2010-10-14 Genentech, Inc. Use of il-27 antagonists to treat lupus
SG175092A1 (en) 2009-04-14 2011-11-28 Novartis Ag Compositions for immunising against staphylococcus aerus
CN101560521B (zh) * 2009-06-01 2011-05-04 陕西师范大学 表达小干扰rna的va1缺失的腺病毒载体的构建方法
WO2010146511A1 (en) 2009-06-17 2010-12-23 Pfizer Limited Treatment of overactive bladder
WO2011005598A1 (en) 2009-06-24 2011-01-13 University Of Southern California Compositions and methods for the rapid biosynthesis and in vivo screening of biologically relevant peptides
CN102625712B (zh) 2009-07-15 2017-07-25 博尔托拉制药公司 用于因子xa抑制剂的解毒剂的单位剂量制剂及其使用方法
WO2011007257A1 (en) 2009-07-16 2011-01-20 Novartis Ag Detoxified escherichia coli immunogens
RU2443779C2 (ru) * 2009-10-09 2012-02-27 Учреждение Российской академии наук Институт молекулярной генетики РАН (ИМГ РАН) Способ получения препарата рекомбинантного аденовируса, характеризующегося сниженным коэффициентом соотношения физических и инфекционных вирусных частиц, и генно-терапевтический лекарственный препарат, полученный таким способом
GB0919690D0 (en) 2009-11-10 2009-12-23 Guy S And St Thomas S Nhs Foun compositions for immunising against staphylococcus aureus
TWI596114B (zh) 2010-02-24 2017-08-21 雷那特神經科學股份有限公司 拮抗劑抗-il-7受體抗體及方法
GB201003333D0 (en) 2010-02-26 2010-04-14 Novartis Ag Immunogenic proteins and compositions
KR20150002894A (ko) 2010-03-11 2015-01-07 리나트 뉴로사이언스 코프. pH 의존성 항원 결합을 갖는 항체
GB201005625D0 (en) 2010-04-01 2010-05-19 Novartis Ag Immunogenic proteins and compositions
WO2011133931A1 (en) 2010-04-22 2011-10-27 Genentech, Inc. Use of il-27 antagonists for treating inflammatory bowel disease
WO2011139688A2 (en) 2010-04-28 2011-11-10 The J. David Gladstone Institutes Methods for generating cardiomyocytes
BR112012028805A2 (pt) 2010-05-10 2019-09-24 The Regents Of The Univ Of California E Nereus Pharmaceuticals Inc composições de endorribonuclease e métodos de uso das mesmas.
EP2580328A2 (de) 2010-06-11 2013-04-17 Cellartis AB Microrna für den nachweis und die isolierung von herzzelltypen aus menschlichen embryonalen stammzellen
EP2598126A2 (de) 2010-07-30 2013-06-05 Saint Louis University Verfahren zur behandlung von schmerz
US9198975B2 (en) 2010-12-01 2015-12-01 The University Of North Carolina At Chapel Hill Methods and compositions for targeting sites of neovascular growth
WO2012072769A1 (en) 2010-12-01 2012-06-07 Novartis Ag Pneumococcal rrgb epitopes and clade combinations
US20130071375A1 (en) 2011-08-22 2013-03-21 Saint Louis University Compositions and methods for treating inflammation
WO2013028527A1 (en) 2011-08-23 2013-02-28 Indiana University Research And Technology Corporation Compositions and methods for treating cancer
US9944675B2 (en) 2011-09-01 2018-04-17 University Of Southern California Methods for preparing high throughput peptidomimetics, orally bioavailable drugs and compositions containing same
CN104053672A (zh) 2011-11-11 2014-09-17 瑞纳神经科学公司 Trop-2特异性抗体及其用途
CN107936097A (zh) 2011-12-16 2018-04-20 斯坦福大学托管董事会 视蛋白多肽及其使用方法
BR112014014824A2 (pt) 2011-12-22 2019-09-24 Rinat Neuroscience Corp anticorpos antagonistas do receptor do hormônio de crescimento humano e métodos de uso dos mesmos
WO2013093693A1 (en) 2011-12-22 2013-06-27 Rinat Neuroscience Corp. Staphylococcus aureus specific antibodies and uses thereof
PT3241902T (pt) 2012-05-25 2018-05-28 Univ California Métodos e composições para modificação de adn alvo dirigida por arn e para modulação dirigida por arn de transcrição
WO2013184209A1 (en) 2012-06-04 2013-12-12 Ludwig Institute For Cancer Research Ltd. Mif for use in methods of treating subjects with a neurodegenerative disorder
IN2015DN00552A (de) 2012-07-19 2015-06-26 Redwood Bioscience Inc
US8603470B1 (en) 2012-08-07 2013-12-10 National Cheng Kung University Use of IL-20 antagonists for treating liver diseases
ES2775192T3 (es) 2012-08-16 2020-07-24 Ipierian Inc Procedimientos de tratamiento de una tauopatía
CN107096041A (zh) 2012-10-17 2017-08-29 脉管生物生长有限公司 使用腺病毒的治疗方法
CA3124553A1 (en) 2012-10-25 2014-05-01 Bioverativ Usa Inc. Anti-complement c1s antibodies and uses thereof
CN116063483A (zh) 2012-11-02 2023-05-05 美国比奥维拉迪维股份有限公司 抗补体C1s抗体和其用途
EP2914281A1 (de) 2012-11-05 2015-09-09 Genzyme Corporation Zusammensetzungen und verfahren zur behandlung von proteinopathien
HK1216428A1 (zh) 2012-11-09 2016-11-11 辉瑞公司 血小板衍生生长因子b之特异性抗体及其组合物和用途
WO2014127148A1 (en) 2013-02-14 2014-08-21 The J. David Gladstone Institutes Compositions and methods of use thereof for identifying anti-viral agents
KR102332790B1 (ko) 2013-02-15 2021-12-01 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 키메라 항원 수용체 및 이의 이용 방법
AU2014236208B2 (en) 2013-03-14 2018-07-19 Genvivo, Inc. Thymidine kinase diagnostic assay for gene therapy applications
US20160039877A1 (en) 2013-03-15 2016-02-11 Shenzhen Hightide Biopharmaceutical, Ltd. Compositions and methods of using islet neogenesis peptides and analogs thereof
KR20150132473A (ko) 2013-03-15 2015-11-25 다이액스 코포레이션 항-혈장 칼리크레인 항체
WO2014181229A2 (en) 2013-05-07 2014-11-13 Rinat Neuroscience Corp. Anti-glucagon receptor antibodies and methods of use thereof
HUE050485T2 (hu) 2013-06-10 2020-12-28 Ipierian Inc Tauopathia kezelési módszerei
WO2014205511A1 (en) 2013-06-25 2014-12-31 University Of Canberra Methods and compositions for modulating cancer stem cells
WO2015006641A2 (en) 2013-07-12 2015-01-15 Georgia State University Research Foundation, Inc. Methods and compositions for interference with dna polymerase and dna synthesis
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
WO2015009955A1 (en) 2013-07-18 2015-01-22 Xalud Therapeutics, Inc. Methods for the treatment of inflammatory joint disease
BR112016002008B1 (pt) 2013-08-02 2021-06-22 Pfizer Inc. Anticorpos anti-cxcr4, seu uso, conjugado anticorpo-fármaco e composição farmacêutica
ES2851724T3 (es) 2013-09-18 2021-09-08 Epiaxis Therapeutics Pty Ltd Modulación de células madre
AU2014348676B2 (en) 2013-11-13 2020-06-18 Bristol-Myers Squibb Company Tumor necrosis factor-like ligand 1A specific antibodies and compositions and uses thereof
US20160298096A1 (en) 2013-11-18 2016-10-13 Crispr Therapeutics Ag Crispr-cas system materials and methods
WO2015087187A1 (en) 2013-12-10 2015-06-18 Rinat Neuroscience Corp. Anti-sclerostin antibodies
US9994831B2 (en) 2013-12-12 2018-06-12 The Regents Of The University Of California Methods and compositions for modifying a single stranded target nucleic acid
WO2015109212A1 (en) 2014-01-17 2015-07-23 Pfizer Inc. Anti-il-2 antibodies and compositions and uses thereof
SI3119431T1 (sl) 2014-03-21 2024-06-28 Teva Pharmaceuticals International Gmbh Antagonistična protitelesa, usmerjena proti peptidu, povezanemu z genom za kalcitonin, in postopki za uporabo le-teh
KR102555955B1 (ko) 2014-03-27 2023-07-18 다케다 파머수티컬 컴패니 리미티드 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법
EP3139955B1 (de) 2014-04-30 2024-03-20 President and Fellows of Harvard College Fusionsproteine zur behandlung von krebs und zugehörige verfahren
WO2015175375A1 (en) 2014-05-13 2015-11-19 Short Jay M Conditionally active biological proteins
AU2015277460B2 (en) 2014-06-18 2020-10-08 Albert Einstein College Of Medicine, Inc. Syntac polypeptides and uses thereof
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
PL3177640T3 (pl) 2014-08-08 2020-11-02 The Board Of Trustees Of The Leland Stanford Junior University Charakteryzujące się wysokim powinowactwem środki terapeutyczne naśladujące PD-11 i sposoby ich wykorzystania
EP3185858A4 (de) 2014-08-25 2017-12-27 University of Canberra Zusammensetzungen zur modulation von krebsstammzellen und verwendungen davon
US11111288B2 (en) 2014-08-28 2021-09-07 Bioatla, Inc. Conditionally active chimeric antigen receptors for modified t-cells
MX2017002605A (es) 2014-08-28 2017-05-19 Bioatla Llc Receptores de antigeno quimerico condicionalmente activos para celulas t modificadas.
CA2959786A1 (en) 2014-09-03 2016-03-10 Bioatla, Llc Discovering and producing conditionally active biologic proteins in the same eukaryotic cell production hosts
US20160074532A1 (en) 2014-09-07 2016-03-17 Selecta Biosciences, Inc. Methods and compositions for attenuating gene editing anti-viral transfer vector immune responses
CN107074969A (zh) 2014-09-09 2017-08-18 优努姆治疗公司 嵌合受体及其在免疫治疗中的应用
GB201417042D0 (en) * 2014-09-29 2014-11-12 Fkd Therapies Oy Method
CN107405390A (zh) 2014-12-05 2017-11-28 阿雷克森制药公司 用重组碱性磷酸酶治疗癫痫
TWI595006B (zh) 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗pd-1抗體類和使用彼等之方法
JP6744313B2 (ja) 2015-01-02 2020-08-26 ダイアックス コーポレーション 血漿カリクレインおよび第xii因子に対する二重特異性抗体
EP3858992A1 (de) 2015-03-13 2021-08-04 The Jackson Laboratory Dreikomponentiges crispr/cas-komplexsystem und verwendungen davon
EP3277291A1 (de) 2015-03-30 2018-02-07 Dana Farber Cancer Institute, Inc. Zusammensetzungen und verfahren zur behandlung akuter myeloischer leukämie
CA2977838A1 (en) 2015-03-30 2016-10-06 Dana-Farber Cancer Institute, Inc. Compositions and methods of treating cancer
US20180085398A1 (en) 2015-03-30 2018-03-29 Dana-Farber Cancer Institute, Inc. Compositions and methods of treating cancer
AU2016243192A1 (en) 2015-03-30 2017-09-07 Beth Israel Deaconess Medical Center Compositions and methods of treating renal cell cancer
US20180071340A1 (en) 2015-03-30 2018-03-15 Dana-Farber Cancer Institute, Inc. Compositions and methods of treating multiple myeloma
US9758575B2 (en) 2015-04-06 2017-09-12 Yung Shin Pharmaceutical Industrial Co. Ltd. Antibodies which specifically bind to canine vascular endothelial growth factor and uses thereof
PT3280440T (pt) 2015-04-06 2023-02-14 Bioverativ Usa Inc Anticorpos anti-c1s humanizados e métodos de utilização destes
AU2016246655B2 (en) 2015-04-07 2021-07-22 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Methods for inducing cell division of postmitotic cells
PL3988117T3 (pl) 2015-04-13 2025-03-10 Pfizer Inc. Przeciwciała terapeutyczne i ich zastosowania
CA2985235A1 (en) 2015-05-07 2016-11-10 Shire Human Genetic Therapies, Inc. Glucocerebrosidase gene therapy for parkinson's disease
EP3303634B1 (de) 2015-06-03 2023-08-30 The Regents of The University of California Cas9-varianten und verfahren zur verwendung davon
WO2017004579A1 (en) 2015-07-01 2017-01-05 O'connor Colleen M Artificial antigen presenting cells for adoptive cell therapy against cancer
WO2017011275A1 (en) 2015-07-10 2017-01-19 Nersissian Aram M Factor viii protein compositions and methods of treating hemophilia a
WO2017015431A1 (en) 2015-07-21 2017-01-26 Dyax Corp. A monoclonal antibody inhibitor of factor xiia
US10877045B2 (en) 2015-07-21 2020-12-29 Saint Louis University Compositions and methods for diagnosing and treating endometriosis-related infertility
US11066481B2 (en) 2015-07-23 2021-07-20 The Regents Of The University Of California Antibodies to coagulation factor XIa and uses thereof
US10940204B2 (en) 2015-07-31 2021-03-09 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
WO2017023861A1 (en) 2015-08-03 2017-02-09 The Regents Of The University Of California Compositions and methods for modulating abhd2 activity
KR102438650B1 (ko) 2015-08-19 2022-08-31 화이자 인코포레이티드 조직 인자 경로 억제제 항체 및 그의 용도
MX2018002610A (es) 2015-09-02 2018-09-27 Immutep Sas Anticuerpos anti-lag-3.
AU2016323447B2 (en) 2015-09-15 2023-03-30 Scholar Rock, Inc. Anti-pro/latent-Myostatin antibodies and uses thereof
AU2016339053A1 (en) 2015-09-24 2018-04-12 Crispr Therapeutics Ag Novel family of RNA-programmable endonucleases and their uses in genome editing and other applications
WO2017066719A2 (en) 2015-10-14 2017-04-20 Research Institute At Nationwide Children's Hospital Hu specific interfering agents
CN108290939B (zh) 2015-10-16 2023-01-13 纽约市哥伦比亚大学理事会 用于抑制谱系特异性抗原的组合物和方法
CN109071648B (zh) 2015-10-23 2022-07-19 辉瑞有限公司 抗il-2抗体及其组合物和用途
WO2017075037A1 (en) 2015-10-27 2017-05-04 Scholar Rock, Inc. Primed growth factors and uses thereof
CN106699889A (zh) 2015-11-18 2017-05-24 礼进生物医药科技(上海)有限公司 抗pd-1抗体及其治疗用途
CA3004597A1 (en) 2015-11-20 2017-05-26 Dana-Farber Cancer Institute, Inc. Compositions and methods of treating cancer
EP3397276A4 (de) 2015-12-30 2019-12-18 Kodiak Sciences Inc. Antikörper und konjugate davon
CA3004491A1 (en) 2016-01-08 2017-07-13 The Regents Of The University Of California Conditionally active heterodimeric polypeptides and methods of use thereof
CN109219618B (zh) 2016-01-21 2022-08-09 辉瑞大药厂 针对表皮生长因子受体变体iii和cd3的单特异性和双特异性抗体及其用途
US20190046648A1 (en) 2016-03-03 2019-02-14 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
US12128102B2 (en) 2016-03-08 2024-10-29 Takeda Pharmaceutical Company Limited Constrained conditionally activated binding proteins
WO2020047527A2 (en) 2018-09-02 2020-03-05 F1 Bioventures, Llc Methods and compositions for genetically modifying lymphocytes in blood or in enriched pbmcs
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
KR102457098B1 (ko) 2016-03-19 2022-10-21 엑수마 바이오테크, 코포레이션 림프구를 형질도입시키기 위한 방법 및 조성물, 및 이의 조절된 확장
US20190125848A1 (en) 2016-03-30 2019-05-02 Dana-Farber Cancer Institute, Inc. Dendritic cell-extracellular vesicle fusions and methods of using same
WO2017176651A1 (en) 2016-04-04 2017-10-12 True North Therapeutics, Inc. Anti-complement factor bb antibodies and uses thereof
HUE055862T2 (hu) 2016-04-20 2021-12-28 Centro De Investig Energeticas Készítmények és eljárások PKLR fokozott génexpressziójára
PL3455261T3 (pl) 2016-05-13 2022-12-12 Bioatla, Inc. Przeciwciała anty-ror2, fragmenty przeciwciał, ich immunokoniugaty oraz ich zastosowania
KR20190019068A (ko) 2016-05-18 2019-02-26 큐 바이오파마, 인크. T-세포 조절 다량체 폴리펩타이드 및 이의 사용 방법
AU2017266905B2 (en) 2016-05-18 2022-12-15 Albert Einstein College Of Medicine, Inc. Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof
EP3472318B1 (de) 2016-07-08 2023-09-06 Exuma Biotech Corp. Verfahren und zusammensetzungen zur transduktion von lymphozyten und regulierung der aktivität davon
US11780895B2 (en) 2016-09-13 2023-10-10 The Jackson Laboratory Targeted DNA demethylation and methylation
US10578610B2 (en) 2016-09-20 2020-03-03 Washington University Peptide regulators of mitochondrial fusion and methods of use
WO2018071676A1 (en) 2016-10-12 2018-04-19 Bioverativ Usa Inc. Anti-c1s antibodies and methods of use thereof
EP3526236B1 (de) 2016-10-17 2025-12-10 Beth Israel Deaconess Medical Center, Inc. Signaturbasierte envelope (env)-trimerimpfstoffe gegen humanes immundefizienz-virus (hiv) und verfahren zur verwendung davon
US20180119141A1 (en) 2016-10-28 2018-05-03 Massachusetts Institute Of Technology Crispr/cas global regulator screening platform
WO2018090026A1 (en) 2016-11-14 2018-05-17 Dana-Farber Cancer Institute, Inc. Compositions and methods of treating cancer
WO2018090028A1 (en) 2016-11-14 2018-05-17 Dana-Farber Cancer Institute, Inc. Compositions and methods of treating cancer
US11332713B2 (en) 2016-11-16 2022-05-17 KSQ Therapeutics, Inc. Gene-regulating compositions and methods for improved immunotherapy
WO2018119114A1 (en) 2016-12-22 2018-06-28 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
US12098188B2 (en) 2017-01-04 2024-09-24 Research Institute At Nationwide Children's Hospital Antibody fragments for the treatment of biofilm-related disorders
JP2020506890A (ja) 2017-01-07 2020-03-05 セレクタ バイオサイエンシーズ インコーポレーテッドSelecta Biosciences,Inc. 合成ナノキャリアにカップリングした免疫抑制剤のパターン化された投与
EP3565829A4 (de) 2017-01-09 2021-01-27 Cue Biopharma, Inc. T-zell-modulierende multimere polypeptide und verfahren zur verwendung davon
AU2018211081B2 (en) 2017-01-18 2025-01-02 Bioatla, Inc. Chimeric antigen receptors against Axl or Ror2 and methods of use thereof
US20190367876A1 (en) 2017-01-18 2019-12-05 F1 Oncology, Inc. Methods of transducing and expanding immune cells and uses thereof
WO2018148246A1 (en) 2017-02-07 2018-08-16 Massachusetts Institute Of Technology Methods and compositions for rna-guided genetic circuits
WO2018148454A1 (en) 2017-02-09 2018-08-16 The Regents Of The University Of California Chimeric t cell antigen receptors and methods of use thereof
MX2019010445A (es) 2017-03-03 2019-10-24 F1 Oncology Inc Metodos y composiciones para transducir y expandir linfocitos y regular la actividad de los mismos.
MX2019010458A (es) 2017-03-03 2020-01-20 Rinat Neuroscience Corp Anticuerpos anti-gitr y metodos de uso de los mismos.
WO2018167621A1 (en) 2017-03-16 2018-09-20 Pfizer Inc. Tyrosine prototrophy
CN110678190A (zh) 2017-03-28 2020-01-10 宾夕法尼亚大学董事会 保护移植的组织免受排斥的方法
CA3057171A1 (en) 2017-03-30 2018-10-04 The University Of Queensland Chimeric polypeptides containing virus fusion ectodomain and complementary heptad repeats and uses thereof
AU2018250695A1 (en) 2017-04-14 2019-11-07 Kodiak Sciences Inc. Complement factor D antagonist antibodies and conjugates thereof
CN111108121A (zh) 2017-04-25 2020-05-05 永福生物科技股份有限公司 Il-20拮抗剂治疗眼病的用途
TWI757499B (zh) 2017-06-02 2022-03-11 美商輝瑞大藥廠 對flt3具特異性之抗體及其用途
US10340030B2 (en) 2017-06-13 2019-07-02 Bostongene Corporation Systems and methods for identifying cancer treatments from normalized biomarker scores
WO2018232372A1 (en) 2017-06-16 2018-12-20 Protelica, Inc. Fibronectin binding domain chimeric antigen receptors and methods of use thereof
WO2019016784A1 (en) 2017-07-21 2019-01-24 Universidade De Coimbra ANTI-NUCLEOLIN ANTIBODIES
JP7105866B2 (ja) 2017-07-25 2022-07-25 オックスフォード ジェネティクス リミテッド アデノウイルスベクター
EP4400174A3 (de) 2017-09-01 2024-10-23 The Francis Crick Institute Limited Immunregulierende moleküle und deren verwendungen
KR20200064085A (ko) 2017-09-07 2020-06-05 큐 바이오파마, 인크. 접합 부위를 갖는 t-세포 조절 다량체 폴리펩타이드 및 이의 사용 방법
EP3679068A2 (de) 2017-09-08 2020-07-15 Maverick Therapeutics, Inc. Bedingt aktivierte fc-regionen enthaltende bindungsteile
PE20212205A1 (es) 2017-09-08 2021-11-18 Maverick Therapeutics Inc Proteinas de union condicionalmente activadas restringidas
WO2019056015A2 (en) 2017-09-18 2019-03-21 Children's Hospital Medical Center STRONG ISOLATOR AND ITS USES IN GENE ADMINISTRATION
KR20210027230A (ko) 2017-10-04 2021-03-10 옵코 파마슈티칼스, 엘엘씨 암의 개인 맞춤형 치료에 관한 물품 및 방법
JP7369121B2 (ja) 2017-10-11 2023-10-25 バイオベラティブ・ユーエスエイ・インコーポレイテッド 補体活性を誘発する方法
KR20200086670A (ko) 2017-10-13 2020-07-17 셀렉타 바이오사이언시즈, 인크. 항바이러스 전달 벡터 IgM 반응을 약화시키기 위한 방법 및 조성물
WO2019079338A1 (en) 2017-10-16 2019-04-25 Centro de Investigaciones Energeticas, Medioambientales Y Tecnologicas, O.A., M.P. LENTIVIRAL VECTORS FOR PKLR ADMINISTRATION TO TREAT PYRUVATE KINASE DEFICIENCY
EP3688011A4 (de) 2017-10-25 2021-11-24 The Administrators Of The Tulane Educational Fund Peptidzusammensetzungen und verfahren zu ihrer verwendung
PT3625263T (pt) 2017-10-27 2025-06-20 Pure Tech Lyt Inc Anticorpos anti-galectina-9 e as suas utilizações
CA3084825A1 (en) 2017-12-14 2019-06-20 Crispr Therapeutics Ag Novel rna-programmable endonuclease systems and their use in genome editing and other applications
WO2019139896A1 (en) 2018-01-09 2019-07-18 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
BR112020015662A2 (pt) 2018-02-01 2020-12-08 Pfizer Inc. Receptores de antígeno quimérico direcionados a cd70
SG11202006988WA (en) 2018-02-01 2020-08-28 Pfizer Antibodies specific for cd70 and their uses
US11667949B2 (en) 2018-02-15 2023-06-06 The Trustees Of Princeton University Reporter construct and biosensor for interferon second messenger 2-5A
CN112384204B (zh) 2018-02-26 2023-03-14 安托瑞斯公司 致耐受性脂质体及其使用方法
KR20200128116A (ko) 2018-02-28 2020-11-11 화이자 인코포레이티드 Il-15 변이체 및 이의 용도
KR20200140817A (ko) 2018-03-02 2020-12-16 코디악 사이언시스 인코포레이티드 Il-6 항체 그리고 이의 융합 작제물 및 접합체
AU2019234926B2 (en) 2018-03-15 2026-02-05 KSQ Therapeutics, Inc. Gene-regulating compositions and methods for improved immunotherapy
BR112020018658A2 (pt) 2018-03-15 2020-12-29 KSQ Therapeutics, Inc. Composições de regulação gênica e métodos para imu-noterapia aprimorada
AU2019239957A1 (en) 2018-03-19 2020-09-10 Bayer Healthcare Llc Novel RNA-programmable endonuclease systems and uses thereof
EP3775229A4 (de) 2018-03-27 2021-12-15 The Trustees Of The University Of Pennsylvania Modifizierte immunzellen mit verbesserter funktion und screening-verfahren dafür
CA3096202A1 (en) 2018-04-06 2019-10-10 The Regents Of The University Of California Methods of treating egfrviii expressing glioblastomas
EP3773633A4 (de) 2018-04-06 2022-01-26 The Regents of The University of California Verfahren zur behandlung von glioblastomen
US12539316B2 (en) 2018-04-11 2026-02-03 Spacecraft Seven, Llc Compositions and methods for stem cell transplant
WO2019222513A1 (en) 2018-05-17 2019-11-21 Regents Of The University Of Minnesota Drug-resistant immune cells and methods of use thereof
EP3796980A4 (de) 2018-05-22 2022-03-23 The Brigham & Women's Hospital, Inc. Neue therapie für morbus alzheimer
BR112020022897A2 (pt) 2018-05-23 2021-02-23 Pfizer Inc. anticorpos específicos para cd3 e usos dos mesmos
JP7057843B2 (ja) 2018-05-23 2022-04-20 ファイザー・インク GUCY2cに特異的な抗体及びその使用
WO2020010110A1 (en) 2018-07-03 2020-01-09 Unum Therapeutics Inc. Chimeric receptors in combination with trans metabolism molecules enhancing glucose import and therapeutic uses thereof
WO2020018166A1 (en) 2018-07-16 2020-01-23 The Regents Of The University Of Michigan Nuclease-mediated nucleic acid modification
US20210309756A1 (en) 2018-08-09 2021-10-07 Maverick Therapeutics, Inc. Coexpression and purification method of conditionally activated binding proteins
US12077785B2 (en) 2018-08-14 2024-09-03 Sotio Biotech Inc. Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating Krebs cycle and therapeutic uses thereof
SG11202101421RA (en) * 2018-08-16 2021-03-30 Spacecraft Seven Llc Production methods for viral vectors
WO2020041456A1 (en) 2018-08-22 2020-02-27 The Regents Of The University Of California Variant type v crispr/cas effector polypeptides and methods of use thereof
EP4512890A3 (de) 2018-08-28 2025-04-30 Vor Biopharma, Inc. Genetisch veränderte hermatopoietische stammzellen und verwendungen davon
CA3111076A1 (en) 2018-08-30 2020-03-05 Tenaya Therapeutics, Inc. Cardiac cell reprogramming with myocardin and ascl1
EP3861021B1 (de) 2018-10-05 2025-02-12 Research Institute at Nationwide Children's Hospital Zusammensetzungen und verfahren zur enzymatischen zerstörung bakterieller biofilme
WO2020078270A1 (en) 2018-10-15 2020-04-23 Elixiron Immunotherapeutics (hong Kong) Limited Antibodies to granulocyte-macrophage colony stimulating factor and uses thereof
WO2020097445A1 (en) 2018-11-09 2020-05-14 Inari Agriculture, Inc. Rna-guided nucleases and dna binding proteins
WO2020112908A2 (en) 2018-11-28 2020-06-04 Casebia Therapeutics Limited Liability Partnership OPTIMIZED mRNA ENCODING CAS9 FOR USE IN LNPs
TWI856047B (zh) 2018-12-19 2024-09-21 美商信號生物製藥公司 多聚體t細胞調節多肽及其使用方法
JP7575102B2 (ja) 2018-12-21 2024-10-29 マルチチュード インコーポレーテッド Muc18に特異的な抗体
WO2020154548A2 (en) 2019-01-23 2020-07-30 New York University Antibodies specific to delta 1 chain of t cell receptor
EP3934762A1 (de) 2019-03-05 2022-01-12 Takeda Pharmaceutical Company Limited Eingeschränkte bedingt aktivierte bindungsproteine
CA3132651A1 (en) 2019-03-05 2020-09-10 Takeda Pharmaceutical Limited Company Conditionally activated binding proteins containing fc regions and moieties targeting tumor antigens
JP7691927B2 (ja) 2019-03-06 2025-06-12 キュー バイオファーマ, インコーポレイテッド T細胞調節抗原提示ポリペプチド及びその使用方法
JP2022522405A (ja) 2019-03-06 2022-04-19 キュー バイオファーマ, インコーポレイテッド T細胞調節多量体ポリペプチド及びその使用方法
JP7239725B2 (ja) 2019-03-07 2023-03-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア CRISPR-Casエフェクターポリペプチド及びその使用方法
CA3132630A1 (en) 2019-03-12 2020-09-17 Crispr Therapeutics Ag Novel high fidelity rna-programmable endonuclease systems and uses thereof
EP3947700A4 (de) 2019-04-01 2023-01-04 Tenaya Therapeutics, Inc. Adeno-assoziiertes virus mit manipuliertem kapsid
KR20220004653A (ko) 2019-04-02 2022-01-11 켄조케티 바이오테크놀러지 인코포레이티드 유출 펌프-암 항원 다중특이적 항체 및 그것과 관련된 조성물, 시약, 키트 및 방법
JP2022531201A (ja) 2019-04-28 2022-07-06 セレクタ バイオサイエンシーズ インコーポレーテッド ウイルス導入ベクターに対する既存の免疫を伴う対象の処置のための方法
EP3976637A4 (de) 2019-05-24 2023-07-12 The Brigham and Women's Hospital, Inc. Gentherapie für morbus alzheimer
CN114206396A (zh) 2019-05-28 2022-03-18 西莱克塔生物科技公司 用于减弱抗病毒转移载体免疫应答的方法和组合物
AU2020327680A1 (en) 2019-07-03 2022-01-20 Bostongene Corporation Systems and methods for sample preparation, sample sequencing, and sequencing data bias correction and quality control
AU2020311897A1 (en) 2019-07-08 2022-02-03 Research Institute At Nationwide Children's Hospital Antibody compositions for disrupting biofilms
US20230137971A1 (en) 2019-07-11 2023-05-04 Tenaya Therapeutics Inc. Cardiac cell reprogramming with micrornas and other factors
EP4003508A1 (de) 2019-07-31 2022-06-01 Memorial Sloan Kettering Cancer Center Perfusionsmodulierte tumordosismodellierung mit einzeldosis-strahlentherapie
EP4041308A1 (de) 2019-10-07 2022-08-17 University of Virginia Patent Foundation Modulation von lymphgefässen bei neurologischen erkrankungen
CN114786731A (zh) 2019-10-10 2022-07-22 科达制药股份有限公司 治疗眼部病症的方法
WO2021072244A1 (en) 2019-10-11 2021-04-15 Beth Israel Deaconess Medical Center, Inc. Anti-tn antibodies and uses thereof
JP7756638B2 (ja) 2019-10-23 2025-10-20 キュー バイオファーマ,インコーポレーテッド TGF-βポリペプチド
MX2022006499A (es) 2019-11-29 2022-08-15 Paros Bio Inc Terapia genica para trastornos neurodegenerativos.
WO2021113736A1 (en) 2019-12-05 2021-06-10 Massachusetts Institute Of Technology Single-domain antibody to chloramphenicol
EP4093426A1 (de) 2020-01-24 2022-11-30 University of Virginia Patent Foundation Modulation von lymphgefässen bei neurologischen erkrankungen
CN115552022A (zh) 2020-03-02 2022-12-30 特纳亚治疗股份有限公司 由心肌细胞表达的微rna控制的基因载体
IL296550A (en) 2020-03-18 2022-11-01 Memorial Sloan Kettering Cancer Center Anti-ceramide antibodies
WO2021205325A1 (en) 2020-04-08 2021-10-14 Pfizer Inc. Anti-gucy2c antibodies and uses thereof
WO2021224850A1 (en) 2020-05-06 2021-11-11 Crispr Therapeutics Ag Mask peptides and masked anti-ptk7 antibodies comprising such
WO2021247423A1 (en) 2020-06-04 2021-12-09 Kenjockety Biotechnology, Inc. Abcg2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
EP4165071A4 (de) 2020-06-15 2024-07-17 Academia Sinica Humanisiertes ace2-fc-fusionsprotein zur behandlung und prävention von sars-cov-2-infektion
EP4182353A1 (de) 2020-07-17 2023-05-24 Janssen Biotech, Inc. Antiidiotypische antikörper gegen anti-klk2-antikörper
WO2022013775A1 (en) 2020-07-17 2022-01-20 Pfizer Inc. Therapeutic antibodies and their uses
WO2022023972A1 (en) 2020-07-30 2022-02-03 Pfizer Inc. Cells having gene duplications and uses thereof
US20230295615A1 (en) 2020-08-07 2023-09-21 The Jackson Laboratory Targeted Sequence Insertion Compositions and Methods
WO2022051406A1 (en) 2020-09-03 2022-03-10 Dalan Animal Health, Inc. Use of vitellogenin for defining and testing novel immunogens in insects
US11781156B2 (en) 2020-10-09 2023-10-10 Tenaya Therapeutics, Inc. Plakophillin-2 gene therapy methods and compositions
US12254961B2 (en) 2020-12-04 2025-03-18 Bostongene Corporation Hierarchical machine learning techniques for identifying molecular categories from expression data
WO2022155500A1 (en) 2021-01-14 2022-07-21 Senti Biosciences, Inc. Secretable payload regulation
WO2022187289A1 (en) 2021-03-01 2022-09-09 Exuma Biotech Corp. Methods and compositions for the delivery of retroviral particles
EP4330969A1 (de) 2021-04-29 2024-03-06 BostonGene Corporation Maschinenlerntechniken zur schätzung der tumorzellenexpression in komplexem tumorgewebe
JP2024520790A (ja) 2021-06-10 2024-05-24 ヤンセン バイオテツク,インコーポレーテツド Klk2-gpi融合タンパク質をコードする核酸、組換え細胞、及びその使用
EP4101928A1 (de) 2021-06-11 2022-12-14 Bayer AG Programmierbare typ-v-rna-endonukleasesysteme
AU2022290382A1 (en) 2021-06-11 2023-11-23 Bayer Aktiengesellschaft Type v rna programmable endonuclease systems
EP4380969A1 (de) 2021-08-02 2024-06-12 Pfizer Inc. Verbesserte expressionsvektoren und verwendungen davon
EP4144841A1 (de) 2021-09-07 2023-03-08 Bayer AG Neue programmierbare rna-endonuklease-systeme mit verbesserter pam-spezifität und deren verwendung
JP2024536859A (ja) 2021-09-27 2024-10-08 ソティオ バイオテック インコーポレイティド 解糖経路からグルコース代謝産物を再誘導するトランス代謝分子と組み合わせたキメラ受容体ポリペプチド及びその治療的使用
WO2023064367A1 (en) 2021-10-12 2023-04-20 Selecta Biosciences, Inc. Methods and compositions for attenuating anti-viral transfer vector igm responses
US20250000906A1 (en) 2021-11-16 2025-01-02 Sotio Biotech Inc. Treatment of myxoid/round cell liposarcoma patients
WO2023091954A2 (en) 2021-11-19 2023-05-25 The Trustees Of The University Of Pennsylvania Engineered pan-leukocyte antigen cd45 to facilitate car t cell therapy
JP2024544054A (ja) 2021-11-30 2024-11-27 サノフィ パスツール インコーポレイテッド ヒトメタニューモウイルスのウイルスベクターに基づくワクチン
WO2023114658A1 (en) 2021-12-13 2023-06-22 Kenjockety Biotechnology, Inc. Anti-abcb1 antibodies
EP4453191A1 (de) 2021-12-23 2024-10-30 Bayer Aktiengesellschaft Neuartige programmierbare endonukleasesysteme für kleine v-rna
US20230245479A1 (en) 2022-01-31 2023-08-03 Bostongene Corporation Machine learning techniques for cytometry
KR20240139082A (ko) 2022-02-02 2024-09-20 화이자 인코포레이티드 시스테인 프로토트로피
WO2023159220A1 (en) 2022-02-18 2023-08-24 Kenjockety Biotechnology, Inc. Anti-cd47 antibodies
WO2023168305A1 (en) 2022-03-01 2023-09-07 Exuma Biotech Corp. Viral particles with membrane-bound hyaluronidase
US20230357437A1 (en) 2022-03-09 2023-11-09 Selecta Biosciences, Inc. Immunosuppressants in combination with anti-igm agents and related dosing
KR20250022020A (ko) 2022-06-10 2025-02-14 바이엘 악티엔게젤샤프트 신규 소형 유형 v rna 프로그램가능한 엔도뉴클레아제 시스템
EP4299739A1 (de) 2022-06-30 2024-01-03 Inari Agriculture Technology, Inc. Zusammensetzungen und verfahren zur genomeditierung
WO2024005863A1 (en) 2022-06-30 2024-01-04 Inari Agriculture Technology, Inc. Compositions, systems, and methods for genome editing
WO2024005864A1 (en) 2022-06-30 2024-01-04 Inari Agriculture Technology, Inc. Compositions, systems, and methods for genome editing
EP4299733A1 (de) 2022-06-30 2024-01-03 Inari Agriculture Technology, Inc. Zusammensetzungen, systeme und verfahren zum genomeditieren
WO2024015561A1 (en) 2022-07-15 2024-01-18 Bostongene Corporation Techniques for detecting homologous recombination deficiency (hrd)
WO2024040208A1 (en) 2022-08-19 2024-02-22 Sotio Biotech Inc. Genetically engineered immune cells with chimeric receptor polypeptides in combination with multiple trans metabolism molecules and therapeutic uses thereof
WO2024040207A1 (en) 2022-08-19 2024-02-22 Sotio Biotech Inc. Genetically engineered natural killer (nk) cells with chimeric receptor polypeptides in combination with trans metabolism molecules and therapeutic uses thereof
WO2024044659A1 (en) 2022-08-24 2024-02-29 Tectonic Therapeutic, Inc. Constitutively active g protein-coupled receptor compositions and methods of use thereof
WO2024068996A1 (en) 2022-09-30 2024-04-04 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection
EP4599057A1 (de) 2022-11-09 2025-08-13 The Regents of University of California Hochdurchsatzentdeckung von mehrteiligen crispr-basierten editoren
JP2025537861A (ja) 2022-11-18 2025-11-20 京都府公立大学法人 マイトファジー誘導のための組成物およびその使用
CN120752335A (zh) 2022-12-13 2025-10-03 拜耳公司 工程化v型rna可编程核酸内切酶及其用途
CN120641566A (zh) 2023-02-06 2025-09-12 蓝岩治疗有限公司 降解决定子融合蛋白及其产生方法和用途
WO2024178397A2 (en) 2023-02-24 2024-08-29 Elevatebio Technologies, Inc. Modified immune effector cells and methods of use
EP4680749A1 (de) 2023-03-15 2026-01-21 Kyoto Prefectural Public University Corporation Peptidexpressionskonstrukte und verwendungen davon
WO2024215987A1 (en) 2023-04-14 2024-10-17 Sotio Biotech Inc. IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES
WO2024215989A1 (en) 2023-04-14 2024-10-17 Sotio Biotech Inc. ENGINEERED IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-2/IL-15 RECEPTOR βγ AGONISTS
GB202307563D0 (en) 2023-05-19 2023-07-05 Univ King Abdullah Sci & Tech Methods and compositions
AU2024277678A1 (en) 2023-05-25 2025-11-27 Dispatch Biotherapeutics, Inc. Synthetic cancer antigens as targets for treating cancers
WO2025007073A2 (en) 2023-06-29 2025-01-02 Dispatch Biotherapeutics, Inc. Synthetic cytokine receptors
WO2025030010A1 (en) 2023-08-01 2025-02-06 Vor Biopharma Inc. Compositions comprising genetically engineered hematopoietic stem cells and methods of use thereof
WO2025038492A1 (en) 2023-08-11 2025-02-20 Abalytics Oncology, Inc. Anti-ctla-4 antibodies and related binding molecules and methods and uses thereof
TW202521691A (zh) 2023-10-06 2025-06-01 美商藍岩醫療公司 經工程化之v型rna可程式核酸內切酶及其用途
WO2025096811A1 (en) 2023-10-31 2025-05-08 Bostongene Corporation Machine learning technique for identifying ici responders and non-responders
WO2025111402A1 (en) 2023-11-21 2025-05-30 Board Of Regents Of The University Of Nebraska Anti-amyloid beta antibodies and related compositions and methods thereof
US20250230251A1 (en) 2023-12-20 2025-07-17 Bristol-Myers Squibb Company Antibodies targeting il-18 receptor beta (il-18rb) and related methods
WO2025165590A1 (en) 2024-02-02 2025-08-07 Seven Bridges Genomics Inc. Techniques for improved tumor mutational burden (tmb) determination using a population-specific genomic reference
WO2025171383A2 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens and related methods and uses
WO2025171388A1 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens with modified domains and related methods and uses
WO2025199352A2 (en) 2024-03-20 2025-09-25 Juno Therapeutics, Inc. Antibodies specific for solute carrier family 34 member 2 (slc34a2)
WO2025240670A2 (en) 2024-05-15 2025-11-20 Abalytics Oncology, Inc. Anti-pd-1 antibodies and related binding molecules and methods and uses thereof
WO2026006767A1 (en) 2024-06-28 2026-01-02 Dispatch Biotherapeutics, Inc. Tethered il-9/il-9r and related engineered cells and methods

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US6410010B1 (en) * 1992-10-13 2002-06-25 Board Of Regents, The University Of Texas System Recombinant P53 adenovirus compositions
AU663702B2 (en) * 1991-03-06 1995-10-19 Board Of Regents, The University Of Texas System Methods and compositions for the selective inhibition of gene expression
US5747469A (en) * 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
FR2688514A1 (fr) * 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
JP3533219B2 (ja) * 1992-11-09 2004-05-31 アメリカ合衆国 標的指向ベクター粒子
FR2704234B1 (fr) * 1993-04-22 1995-07-21 Centre Nat Rech Scient Virus recombinants, preparation et utilisation en therapie genique.
AU7019494A (en) * 1993-05-20 1994-12-20 Baylor College Of Medicine Genetic therapy for cardiovascular disease
US20050031590A9 (en) * 1993-10-25 2005-02-10 Richard Gregory Adenoviral vectors having a protein IX deletion
TW442569B (en) * 1993-10-25 2001-06-23 Canji Inc Recombinant adenoviral vector
ATE314482T1 (de) * 1993-10-25 2006-01-15 Canji Inc Rekombinante adenoviren-vektor und verfahren zur verwendung
US20010006629A1 (en) * 1993-10-25 2001-07-05 Richard J. Gregory Recombinant adenoviral vector and methods of use
US6210939B1 (en) * 1993-10-25 2001-04-03 Canji, Inc. Recombinant adenoviral vector and methods of use
JP4214239B2 (ja) * 1996-11-19 2009-01-28 ザ ユーナヴァーサティ オブ アラバマ アト バーミングハム リサーチ ファンデーション 二機能性レトロウイルス/アデノウイルス系
US20030064949A1 (en) * 1998-02-17 2003-04-03 Loretta Nielsen Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
CA2283461A1 (en) * 1997-03-14 1998-09-17 Uab Research Foundation Adenoviral vectors with modified tropism

Also Published As

Publication number Publication date
FI961755A0 (fi) 1996-04-24
EP0797676B9 (de) 2006-06-28
SK51096A3 (en) 1996-10-02
EP1637608A3 (de) 2006-04-05
EP1637608B1 (de) 2009-07-22
PL186073B1 (pl) 2003-10-31
ES2328585T3 (es) 2009-11-16
US20080299083A1 (en) 2008-12-04
SK283703B6 (sk) 2003-12-02
NO961639D0 (no) 1996-04-24
HU223733B1 (hu) 2004-12-28
JPH09507051A (ja) 1997-07-15
ES2256842T4 (es) 2007-02-01
DE69435223D1 (de) 2009-09-03
CA2173975A1 (en) 1995-05-04
NZ275956A (en) 1997-09-22
EP2113569A1 (de) 2009-11-04
BR9407956A (pt) 1996-11-26
US20090088398A1 (en) 2009-04-02
US20090082289A1 (en) 2009-03-26
ATE437232T1 (de) 2009-08-15
NO961639L (no) 1996-06-24
EP1637608A2 (de) 2006-03-22
WO1995011984A2 (en) 1995-05-04
HU9601073D0 (en) 1996-06-28
DE69434594T2 (de) 2006-09-21
US20080175818A1 (en) 2008-07-24
PL314239A1 (en) 1996-09-02
CZ114396A3 (en) 1996-11-13
AU8125094A (en) 1995-05-22
DK0797676T3 (da) 2006-04-18
EP0797676B1 (de) 2005-12-28
CZ291372B6 (cs) 2003-02-12
PT797676E (pt) 2006-05-31
AU687117B2 (en) 1998-02-19
CN1263864C (zh) 2006-07-12
EP0797676A2 (de) 1997-10-01
DE69434594D1 (de) 2006-02-02
CN1147837A (zh) 1997-04-16
US20080182807A1 (en) 2008-07-31
JP3875990B2 (ja) 2007-01-31
RU2162342C2 (ru) 2001-01-27
CA2173975C (en) 2007-06-12
WO1995011984A3 (en) 1995-07-06
FI961755A7 (fi) 1996-06-04
ES2256842T3 (es) 2006-07-16
HUT77575A (hu) 1998-06-29

Similar Documents

Publication Publication Date Title
DE69435223D1 (de) Rekombinanter Adenoviren-Vektor und Verfahren zur Verwendung
HUP0002095A2 (hu) Vegyületek prosztatarák immunterápiás kezelésére és alkalmazásuk
TW581808B (en) Compounds for immunotherapy of prostate cancer and methods for their use
BR0009505A (pt) Compostos e processos para terapia e diagnóstico de câncer de pulmão
IL138330A0 (en) Polynucleotides, polypeptides and pharmaceutical compositions for treating lung cancer
ATE407949T1 (de) Charakterisierung der proteinfamilie von soc/crac kalziumkanälen
ATE394484T1 (de) Smad 6 und dessen anwendungen
ATE119915T1 (de) Dns-sequenzen, rekombinante dns-moleküle und verfahren zur herstellung von ''mullerian inhibiting substance''-ähnlichen polypeptiden.
PT737207E (pt) Inibidores de plasmina humana derivados de dominios kunitz
DE69924826D1 (de) Verwendung vom krebs-assoziierten antigen 5t4 zur immuntherapie
WO1999053061A3 (en) Tumor associated nucleic acids and uses therefor
ATE229977T1 (de) Peptide mit antiproliferativen eigenschaften
GR852940B (de)
DE60230456D1 (de) Faktor-viii-polypeptide auf hohem expressionsnivea und verwendungsverfahren
DK0781344T3 (da) Hidtil ukendt implantat og hidtil ukendt vektor til behandling af erhvervede sygdomme
ES2170082T3 (es) Transactivador de mhc clase ii (ciita) y sus usos.
ATE402259T1 (de) Lage-1 tumor-assozierte nukleinsäuren
IL108584A0 (en) Cloning of interferon - alpha beta binding protein

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0797676

Country of ref document: EP

REN Ceased due to non-payment of the annual fee