AR100039A1 - Conjugados de oligómero de ácido hialurónico o de una sal del mismo, método de preparación del mismo y uso del mismo - Google Patents

Conjugados de oligómero de ácido hialurónico o de una sal del mismo, método de preparación del mismo y uso del mismo

Info

Publication number
AR100039A1
AR100039A1 ARP150100737A ARP150100737A AR100039A1 AR 100039 A1 AR100039 A1 AR 100039A1 AR P150100737 A ARP150100737 A AR P150100737A AR P150100737 A ARP150100737 A AR P150100737A AR 100039 A1 AR100039 A1 AR 100039A1
Authority
AR
Argentina
Prior art keywords
same
conjugates
salt
preparation
oligómero
Prior art date
Application number
ARP150100737A
Other languages
English (en)
Inventor
Velebny Vladimir
Hromek Leos
Sedova Petra
Kotland Ondrej
Ehlova Tereza
Nesporova Kristina
Basarabova Ivana
Buffa Radovan
Original Assignee
Contipro Biotech Sro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Contipro Biotech Sro filed Critical Contipro Biotech Sro
Publication of AR100039A1 publication Critical patent/AR100039A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente se relaciona con conjugados de oligómeros de ácido hialurónico de acuerdo con las fórmulas generales (1), (2), (3) ó (4), o una sal de los mismos, el método de preparación del mismo y el uso del mismo, donde el oligómero se une al sustrato respectivo por su centro anomérico terminal a través de un ligando amino bifuncional por medio de un enlace amino o imino. Este tipo de conjugados permite la liberación de los oligómeros en su forma nativa. Los sistemas preparados exhibieron una actividad biológica mejorada contra líneas de células cancerosas seleccionadas.
ARP150100737A 2014-03-11 2015-03-11 Conjugados de oligómero de ácido hialurónico o de una sal del mismo, método de preparación del mismo y uso del mismo AR100039A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ2014-150A CZ305153B6 (cs) 2014-03-11 2014-03-11 Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití

Publications (1)

Publication Number Publication Date
AR100039A1 true AR100039A1 (es) 2016-09-07

Family

ID=53039131

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150100737A AR100039A1 (es) 2014-03-11 2015-03-11 Conjugados de oligómero de ácido hialurónico o de una sal del mismo, método de preparación del mismo y uso del mismo

Country Status (13)

Country Link
US (1) US10023658B2 (es)
EP (1) EP3116514B1 (es)
JP (1) JP6649892B2 (es)
KR (1) KR102420500B1 (es)
AR (1) AR100039A1 (es)
BR (1) BR112016020644A8 (es)
CZ (1) CZ305153B6 (es)
DK (1) DK3116514T3 (es)
ES (1) ES2710801T3 (es)
HU (1) HUE043758T2 (es)
PL (1) PL3116514T3 (es)
RU (1) RU2682509C2 (es)
WO (1) WO2015135511A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2012842A3 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
CZ305153B6 (cs) * 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
CZ306479B6 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
WO2020085734A1 (ko) * 2018-10-24 2020-04-30 주식회사 화이바이오메드 히알루론산 말단의 알데하이드 그룹을 이용하여 제조한 약물 접합체
US20220213233A1 (en) * 2019-04-19 2022-07-07 Jointherapeutics S.R.L. Crosslinked polymer of functionalized hyaluronic acid and its use in the treatment of inflammatory states

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HUE043758T2 (hu) 2019-09-30
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