CZ2012844A3 - Fotoreaktivní derivát kyseliny hyaluronové, způsob jeho přípravy, 3D síťovaný derivát kyseliny hyaluronové, způsob jeho přípravy a použití - Google Patents

Fotoreaktivní derivát kyseliny hyaluronové, způsob jeho přípravy, 3D síťovaný derivát kyseliny hyaluronové, způsob jeho přípravy a použití

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Publication number
CZ2012844A3
CZ2012844A3 CZ2012-844A CZ2012844A CZ2012844A3 CZ 2012844 A3 CZ2012844 A3 CZ 2012844A3 CZ 2012844 A CZ2012844 A CZ 2012844A CZ 2012844 A3 CZ2012844 A3 CZ 2012844A3
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CZ
Czechia
Prior art keywords
derivative
hyaluronic acid
photoreactive
preparation
formula
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Application number
CZ2012-844A
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English (en)
Other versions
CZ304267B6 (cs
Inventor
Tomáš Bobula
Robert Pospíšil
Radovan Buffa
Jana Růžičková
Martina Moravcová
Pavel Klein
Vladimír Velebný
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Contipro Biotech S.R.O.
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Publication date
Application filed by Contipro Biotech S.R.O. filed Critical Contipro Biotech S.R.O.
Priority to CZ2012-844A priority Critical patent/CZ2012844A3/cs
Priority to PCT/CZ2013/000155 priority patent/WO2014082608A1/en
Priority to RU2015125077A priority patent/RU2015125077A/ru
Priority to BR112015011896A priority patent/BR112015011896A2/pt
Priority to KR1020157015546A priority patent/KR20150082619A/ko
Priority to US14/647,185 priority patent/US20150291706A1/en
Priority to EP13814822.6A priority patent/EP2925792A1/en
Priority to JP2015543315A priority patent/JP2016506422A/ja
Priority to ARP130104358A priority patent/AR095455A1/es
Publication of CZ304267B6 publication Critical patent/CZ304267B6/cs
Publication of CZ2012844A3 publication Critical patent/CZ2012844A3/cs

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
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    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
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    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
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    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
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    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Podstatou řešení je fotoreaktivní derivát kyseliny hyaluronové (vzorce I) a způsob jeho přípravy, kdy se nejprve připraví derivát kyseliny hyaluronové v podobě aldehydu v poloze 6 glukosaminového cyklu, který následně reaguje s aminem nesoucím pyridonový skelet (fotoreaktivní částici), například 1-(2-aminoethyl)pyridin-2(1H)-onem, v přítomnosti redukčního činidla za vzniku fotoreaktivního derivátu. Připravený fotoreaktivní derivát lze následně fotochemicky síťovat prostřednictvím [4+4] fotocykloadičních reakcí. Řešení se dále týká 3D síťovaného derivátu kyseliny hyaluronové (vzorce II), který prokazuje zvýšenou hydrolytickou stabilitu a zlepšené sorpční vlastnosti, s možnostmi dalšího dizajnu jejich fyzikálních vlastností podle požadavků finálních aplikací, a dále jeho použití v tkáňovém inženýrství, regenerativní medicíně, zdravotnických prostředcích, či kosmetice.
CZ2012-844A 2012-11-27 2012-11-27 Fotoreaktivní derivát kyseliny hyaluronové, způsob jeho přípravy, 3D síťovaný derivát kyseliny hyaluronové, způsob jeho přípravy a použití CZ2012844A3 (cs)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CZ2012-844A CZ2012844A3 (cs) 2012-11-27 2012-11-27 Fotoreaktivní derivát kyseliny hyaluronové, způsob jeho přípravy, 3D síťovaný derivát kyseliny hyaluronové, způsob jeho přípravy a použití
PCT/CZ2013/000155 WO2014082608A1 (en) 2012-11-27 2013-11-26 Photoreactive derivative of hyaluronic acid, method of preparation thereof, 3d-crosslinked derivative of hyaluronic acid, method of preparation and use thereof
RU2015125077A RU2015125077A (ru) 2012-11-27 2013-11-26 Фотореактивное производное гиалуроновой кислоты, способ его получения, 3d-сшитое производное гиалуроновой кислоты, способ его получения и применение
BR112015011896A BR112015011896A2 (pt) 2012-11-27 2013-11-26 derivado fotorreativo de ácido hialurônico, método de preparação do derivado fotorreativo, método de preparação de derivados 3d reticulados de ácido hialurônico, derivado 3d reticulado de ácido hialurônico e uso do derivado 3d reticulado
KR1020157015546A KR20150082619A (ko) 2012-11-27 2013-11-26 히알루론산의 광반응성 유도체, 이의 제조 방법, 히알루론산의 3ｄ-가교된 유도체, 이의 제조 방법 및 용도
US14/647,185 US20150291706A1 (en) 2012-11-27 2013-11-26 Photoreactive Derivative of Hyaluronic Acid, Method of Preparation Thereof, 3D.Crosslinked Derivative of Hyaluronic Acid, Method of Preparation and Use Thereof
EP13814822.6A EP2925792A1 (en) 2012-11-27 2013-11-26 Photoreactive derivative of hyaluronic acid, method of preparation thereof, 3d-crosslinked derivative of hyaluronic acid, method of preparation and use thereof
JP2015543315A JP2016506422A (ja) 2012-11-27 2013-11-26 ヒアルロン酸の光反応性誘導体，その調製方法，ヒアルロン酸の３ｄ架橋誘導体，その調製方法及び使用
ARP130104358A AR095455A1 (es) 2012-11-27 2013-11-27 Derivado fotorreactivo del ácido hialurónico, método para su preparación, derivado del ácido hialurónico con entrecruzamiento tridimensional, método para su preparación y sus usos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ2012-844A CZ2012844A3 (cs) 2012-11-27 2012-11-27 Fotoreaktivní derivát kyseliny hyaluronové, způsob jeho přípravy, 3D síťovaný derivát kyseliny hyaluronové, způsob jeho přípravy a použití

Publications (2)

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CZ304267B6 CZ304267B6 (cs) 2014-02-05
CZ2012844A3 true CZ2012844A3 (cs) 2014-02-05

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CZ2012-844A CZ2012844A3 (cs) 2012-11-27 2012-11-27 Fotoreaktivní derivát kyseliny hyaluronové, způsob jeho přípravy, 3D síťovaný derivát kyseliny hyaluronové, způsob jeho přípravy a použití

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US (1) US20150291706A1 (cs)
EP (1) EP2925792A1 (cs)
JP (1) JP2016506422A (cs)
KR (1) KR20150082619A (cs)
AR (1) AR095455A1 (cs)
BR (1) BR112015011896A2 (cs)
CZ (1) CZ2012844A3 (cs)
RU (1) RU2015125077A (cs)
WO (1) WO2014082608A1 (cs)

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CZ2013913A3 (cs) * 2013-11-21 2015-06-03 Contipro Biotech S.R.O. Objemný nanovlákenný materiál na bázi kyseliny hyaluronové, jejích solí nebo jejich derivátů, způsob jeho přípravy, způsob jeho modifikace, modifikovaný nanovlákenný materiál, nanovlákenný útvar a jejich použití
CZ2013914A3 (cs) * 2013-11-21 2015-02-25 Contipro Biotech S.R.O. Nanovlákna obsahující fototvrditelný esterový derivát kyseliny hyaluronové nebo její soli, fototvrzená nanovlákna, způsob jejich syntézy, přípravek obsahující fototvrzená nanovlákna a jejich použití
CZ2014150A3 (cs) 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
CZ306479B6 (cs) * 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
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WO2022063312A1 (zh) * 2020-09-28 2022-03-31 吾奇生物医疗科技(江苏)有限公司 透明质酸水凝胶和透明质酸膜及其制备方法和应用
CN114316085B (zh) * 2021-12-22 2023-06-02 北京佗林医药科技有限公司 一种顺式透明质酸六糖及其制备方法和用途
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JP2016506422A (ja) 2016-03-03
EP2925792A1 (en) 2015-10-07
WO2014082608A1 (en) 2014-06-05
RU2015125077A (ru) 2017-01-10
BR112015011896A2 (pt) 2017-07-11
KR20150082619A (ko) 2015-07-15
CZ304267B6 (cs) 2014-02-05
US20150291706A1 (en) 2015-10-15
AR095455A1 (es) 2015-10-21

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