AR098014A1 - Compuestos de quinolina selectivamente sustituida - Google Patents
Compuestos de quinolina selectivamente sustituidaInfo
- Publication number
- AR098014A1 AR098014A1 ARP140103811A ARP140103811A AR098014A1 AR 098014 A1 AR098014 A1 AR 098014A1 AR P140103811 A ARP140103811 A AR P140103811A AR P140103811 A ARP140103811 A AR P140103811A AR 098014 A1 AR098014 A1 AR 098014A1
- Authority
- AR
- Argentina
- Prior art keywords
- methyl
- optionally substituted
- phenyl
- alkyl
- oxo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Abstract
Compuestos de quinolina selectivamente sustituida que actúan como antagonistas o inhibidores de los receptores similares a Toll 7 y/o 8, y su uso en composiciones farmacéuticas eficaces para el tratamiento de lupus eritematoso sistémico (SLE) y nefritis por lupus, donde Toll son proteínas del sistema inmunológico innato. Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1), en donde por lo menos uno de R¹ y R² es -H, metilo, o etilo, y el otro es -H; o el otro es C₁₋₆ alquilo que opcionalmente está sustituido con: -OH, metoxilo, etoxilo, -OCH(CH₃)₂, -O(CH₂)₂CH₃, fenilo, furanilo, -O(CH₂)₂OH, fenoxilo, metiltio, -F, -N(CH₃)₂, ciano, piridiniloxilo, fluorofenoxilo, isocromanil, fenol, bencilamino, -NHCH₃, oxo-, amino, carboxilo, espiroaminilo de 7 miembros, un cicloalquilo de entre tres y seis miembros, saturado o insaturado y que opcionalmente incluye a uno o más heteroátomos que se eligen de O y N, y opcionalmente sustituido en uno o más átomos de C o N con metilo, ciano, fluoro, metilamino, o trifluorometil; o el otro es C₃₋₇ cicloalcano, saturado o insaturado, opcionalmente puenteado, opcionalmente que incluye uno o más heteroátomos que se eligen de O, S, y N, y opcionalmente sustituido en uno o más átomos de C o N con metilo, etilo, piridinilo, azetidinilo, acetamidilo, carboxamidilo, ciano, fluoro, metilamino, o trifluorometil; o R¹ y R², junto con el átomo de nitrógeno al cual están unidos, forman una espirodiamina de entre 8 y 11 miembros, una biciclodiamina de 8 miembros, una espiroxamina 7 miembros, un piperidinilo opcionalmente sustituido con etilo, o un cicloalquilo de entre cuatro y seis miembros, opcionalmente sustituido con por lo menos uno de carboxamidilo, aminometilo, metilo, (etilamino)metilo, (dimetilamino)metilo, dimetilamino, (metilamino)metilo, y amino; y en donde R³ es -H o metilo. Reivindicación 6: Un compuesto caracterizado porque es de fórmula (2) en donde R⁴ es -H o metilo; R⁵ es C₁₋₅ alquilo que está saturado, parcialmente saturado, o insaturado, y que opcionalmente está sustituido con: -H, -Cl, -F, -OH, -NH₂, oxo-, -N(CH₂CH₃)₂, fenilo, ciclohexilo, feniltriazolilo, ciclohexiltriazolilo, piridinilo, pirrolidinilo, morfolinilo opcionalmente sustituido con metilo o hidroximatilo, -O-, sustituido con: C₁₋₆ alquilo, metilfenilo, metilciclohexilo, piridinilo, diazinilo, o fenilo opcionalmente sustituido con -F o metilo, -NH-, sustituido con: C₂₋₇ alquilo que es lineal, ramificado, o cíclico, saturado o insaturado, y opcionalmente sustituido con oxo-, fenilo, metilo, o -OH, piridinilo opcionalmente sustituido con metilo, metoxilo, fenilo, o amino, diazinilo opcionalmente sustituido con etilo, benzoimidazolilo, metilfenilo, fenilpirazolilo, naftiridilo, fenilo opcionalmente sustituido con -F, metilo, etilo, o etoxilo, imidazolidinilo opcionalmente sustituido con metilo, o R⁵ es un resto de fórmula (4) en donde n es 1 - 3, y en donde la amina cíclica está opcionalmente sustituida con C₁₋₃ alquilo opcionalmente sustituido con -OH, -F, fenilo, -NH₂, ciclohexilo, -N(CH₃)₂, -C(O)NH₂, metilsulfonamidilo, bencenosulfonamidilo, metilbencenosulfonamidilo, o pirrolidinilo opcionalmente sustituido con metilo o hidroxilo, o -NHC(O)R⁶, en donde R⁶ es C₁₋₅ alquilo, fenilo, piridinilo, fluorofenilo, metilsulfonilo, fluorobencenosulfonilo, dimetil pirazol sulfonilo, o pirazolilo opcionalmente sustituido con metilo; piperidinilo opcionalmente sustituido con -C(O)CH₂CH₃, metilo, oxo-, C(O)Ph, -NH₂, -NH-C(O)CH₃, o un resto de fórmula (5), piperazinilo opcionalmente sustituido con -C(O)OC(CH₃)₃, metilo, -C(O)Ph, C(O)CH(CH₃)₂, -C(O)CH₃, o metilsulfonilo; o R⁵ es un resto de fórmula (6), en donde n es 1 ó 2, y en donde la diamina cíclica está opcionalmente sustituida sobre por lo menos un átomo de carbono con metilo, oxo-, -N(CH₃)₂, amino, -CH₂CH₃, o piperidinilo opcionalmente sustituido con metilo, -C(O)CH₃, -C(O)CH(CH₃)₂, -C(O)Ph, o -C(O)OC(CH₃)₃, y en donde R⁷ es -H, fenilo, -C(O)CH₃, C₁₋₃ alquilo, -C(O)NH₂, o -C(O)Ph; y R⁸ es metoxilo o ciano. Reivindicación 9: Un compuesto caracterizado porque es de fórmula (3) en donde R¹¹ es H o metilo; R¹⁰ es H o, cuando tanto R¹¹ como R⁹ son H, es metil-1,4-bipiperidinilo; R⁹ es -H o es -CH₂- sustituido con 1,4-bipiperidinilo, oxo-, hidroxilo, metilpiridinilo, o piperidinilo opcionalmente sustituido con hidroxilo, -N(CH₃)₂, o piperidinilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361890718P | 2013-10-14 | 2013-10-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR098014A1 true AR098014A1 (es) | 2016-04-27 |
Family
ID=51842881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140103811A AR098014A1 (es) | 2013-10-14 | 2014-10-14 | Compuestos de quinolina selectivamente sustituida |
Country Status (35)
Country | Link |
---|---|
US (5) | US9428495B2 (es) |
EP (3) | EP3057964B1 (es) |
JP (3) | JP6223563B2 (es) |
KR (2) | KR101823488B1 (es) |
CN (2) | CN110105346B (es) |
AR (1) | AR098014A1 (es) |
AU (2) | AU2014334554B2 (es) |
BR (1) | BR112016008359B1 (es) |
CA (1) | CA2927510C (es) |
CL (1) | CL2016000662A1 (es) |
CY (1) | CY1122776T1 (es) |
DK (1) | DK3057964T3 (es) |
ES (1) | ES2773303T3 (es) |
HK (1) | HK1223092A1 (es) |
HR (1) | HRP20200147T1 (es) |
HU (1) | HUE048706T2 (es) |
IL (2) | IL245131B (es) |
JO (1) | JO3554B1 (es) |
LT (1) | LT3057964T (es) |
MA (1) | MA39034B1 (es) |
MD (1) | MD4635C1 (es) |
MX (2) | MX364657B (es) |
MY (1) | MY192489A (es) |
PE (1) | PE20160608A1 (es) |
PH (1) | PH12016500642A1 (es) |
PL (1) | PL3057964T3 (es) |
PT (1) | PT3057964T (es) |
RS (1) | RS59911B1 (es) |
RU (1) | RU2679622C2 (es) |
SG (3) | SG11201602818TA (es) |
SI (1) | SI3057964T1 (es) |
TW (2) | TWI624467B (es) |
UA (1) | UA120039C2 (es) |
WO (1) | WO2015057659A1 (es) |
ZA (4) | ZA201601882B (es) |
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MX363708B (es) | 2013-10-14 | 2019-03-29 | Eisai R&D Man Co Ltd | Compuestos de quinolina selectivamente sustituidos. |
AU2014334554B2 (en) * | 2013-10-14 | 2018-12-06 | Eisai R&D Management Co., Ltd. | Selectively substituted quinoline compounds |
AU2016371014B2 (en) | 2015-12-17 | 2021-07-01 | Merck Patent Gmbh | Polycyclic TLR7/8 antagonists and use thereof in the treatment of immune disorders |
US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
CA3031675A1 (en) | 2016-07-30 | 2018-02-08 | Bristol-Myers Squibb Company | Dimethoxyphenyl substituted indole compounds as tlr7, tlr8 or tlr9 inhibitors |
EP4198031A1 (en) * | 2016-08-08 | 2023-06-21 | Merck Patent GmbH | Tlr7/8 antagonists and uses thereof |
KR102519535B1 (ko) * | 2016-09-09 | 2023-04-06 | 브리스톨-마이어스 스큅 컴퍼니 | 피리딜 치환된 인돌 화합물 |
PT3510033T (pt) * | 2016-09-09 | 2022-02-18 | Novartis Ag | Compostos e composições como inibidores de recetores endossomais do tipo toll |
PE20191353A1 (es) | 2016-10-14 | 2019-10-01 | Prec Biosciences Inc | Meganucleasas disenadas especificamente para el reconocimiento de secuencias en el genoma del virus de la hepatitis b |
CA3070171A1 (en) * | 2017-07-18 | 2019-01-24 | Merck Patent Gmbh | Tlr7/8 antagonists and uses thereof |
CN110997656B (zh) | 2017-08-04 | 2023-04-14 | 百时美施贵宝公司 | 用作tlr7/8/9抑制剂的取代的吲哚化合物 |
WO2019028301A1 (en) | 2017-08-04 | 2019-02-07 | Bristol-Myers Squibb Company | INDOLE COMPOUNDS SUBSTITUTED WITH [1,2,4] TRIAZOLO [4,3-A] PYRIDINYL |
CN117586108A (zh) | 2017-10-30 | 2024-02-23 | 科罗拉多州立大学董事会法人团体 | Toll样受体8(tlr8)特异性拮抗剂及其制备方法和用途 |
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