AR074060A1 - Moduladores del regulador de conductancia transmembrana de la fibrosis quistica - Google Patents
Moduladores del regulador de conductancia transmembrana de la fibrosis quisticaInfo
- Publication number
- AR074060A1 AR074060A1 ARP090104089A ARP090104089A AR074060A1 AR 074060 A1 AR074060 A1 AR 074060A1 AR P090104089 A ARP090104089 A AR P090104089A AR P090104089 A ARP090104089 A AR P090104089A AR 074060 A1 AR074060 A1 AR 074060A1
- Authority
- AR
- Argentina
- Prior art keywords
- modulators
- hydrogen
- driving regulator
- transmembrane
- chemical fibrosis
- Prior art date
Links
- 206010016654 Fibrosis Diseases 0.000 title 1
- 230000004761 fibrosis Effects 0.000 title 1
- 108010079245 Cystic Fibrosis Transmembrane Conductance Regulator Proteins 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 102000008371 intracellularly ATP-gated chloride channel activity proteins Human genes 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 102100023419 Cystic fibrosis transmembrane conductance regulator Human genes 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract
Se refiere a moduladores del regulador de conductancia transmembrana de fibrosis quística ("CFTR"), a composiciones de los mismos y métodos que los utilicen. La presente también se refiere a métodos para tratar enfermedades utilizando moduladores de CFTR. Reivindicacion 1: Un compuesto de Formula (1) o una sal aceptable para uso farmacéutico de los mismos: el anillo A se selecciono de: grupo de formulas (2) donde: R1 es -CF3, -CN o -C:::CCH2N(CH3)2; R2 es hidrogeno, -CH3, -CF3, -OH o -CH2OH; R3 es hidrogeno, -CH3, -OCH3 o -CN; con la condicion que ambos R2 y R3 no sean hidrogeno en forma simultánea.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10783008P | 2008-10-23 | 2008-10-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR074060A1 true AR074060A1 (es) | 2010-12-22 |
Family
ID=42119997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090104089A AR074060A1 (es) | 2008-10-23 | 2009-10-23 | Moduladores del regulador de conductancia transmembrana de la fibrosis quistica |
Country Status (28)
Country | Link |
---|---|
US (4) | US8513282B2 (es) |
EP (1) | EP2349263B1 (es) |
JP (1) | JP5645833B2 (es) |
KR (1) | KR20110074917A (es) |
CN (1) | CN102227424B (es) |
AR (1) | AR074060A1 (es) |
AU (1) | AU2009308284B2 (es) |
BR (1) | BRPI0919930A2 (es) |
CA (1) | CA2741718A1 (es) |
CL (1) | CL2011000919A1 (es) |
CY (1) | CY1115369T1 (es) |
DK (1) | DK2349263T3 (es) |
EA (1) | EA018891B1 (es) |
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