AR058249A2 - Una molecula aislada de polinucleotido que comprende una secuencia de adn que codifica una molecula infecciosa de arn que codifica un virus prrs norteamericano, celula transfectada y vacuna - Google Patents

Una molecula aislada de polinucleotido que comprende una secuencia de adn que codifica una molecula infecciosa de arn que codifica un virus prrs norteamericano, celula transfectada y vacuna

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Publication number
AR058249A2
AR058249A2 ARP070101362A AR058249A2 AR 058249 A2 AR058249 A2 AR 058249A2 AR P070101362 A ARP070101362 A AR P070101362A AR 058249 A2 AR058249 A2 AR 058249A2
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Argentina
Prior art keywords
molecula
nucleotide
dna sequence
prrs virus
vaccine
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English (en)
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Pfizer Prod Inc
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Publication of AR058249A2 publication Critical patent/AR058249A2/es

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Abstract

Una molécula aislada de polinucléotido caracterizada porque comprende una secuencia de ADN que codifica una molécula infecciosa de ARN que codifica un virus PRRS norteamericano que está genéticamente modificado de modo tal que comprende uno o más epítopes antigénicos heterologos, donde la secuencia de ADN que codifica la molécula de ARN que codifica el virus PRRS norteamericano es SEQ ID. N°1 o es la secuencia que comienza con e incluye desde el nucleotido 1 hasta incluir el nucleotido 15416 de la SEQ ID. N°1; excepto que el nucleotido que corresponde al nucleotido 12622 de la SEQ ID. N° 1 es una guanina en un lugar de una adenina y el nucleotido que corresponde al nucleotido 1559 de la SEQ. ID. N° 1 es una timina en lugar de una citosina, excepto que comprende uno o más secuencias de nucleotidos adicionales que codifican epítopes antigénicos heterologos, donde cada epítope antigénico heterologo es capaz de inducir una respuesta inmunoportectora efectiva contra un patogeno particular en un mamífero o en un pájaro. Se describe también una célula huésped transfectada, y una vacuna.
ARP070101362 1998-12-22 2007-03-30 Una molecula aislada de polinucleotido que comprende una secuencia de adn que codifica una molecula infecciosa de arn que codifica un virus prrs norteamericano, celula transfectada y vacuna AR058249A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11334598P 1998-12-22 1998-12-22

Publications (1)

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AR058249A2 true AR058249A2 (es) 2008-01-30

Family

ID=22348908

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP990106325 AR025146A1 (es) 1998-12-22 1999-12-13 UNA MOLÉCULA AISLADA DE POLINUCLEoTIDO QUE COMPRENDE UNA SECUENCIA DE ADN QUE CODIFICA UN VIRUS PRRS NORTEAMERICANO, CÉLULA HUESPED, PLÁSMIDO, MÉTODO PARA GENERAR UN VIRUS PRRS NORTEAMERICANO Y VACUNA.
ARP070101362 AR058249A2 (es) 1998-12-22 2007-03-30 Una molecula aislada de polinucleotido que comprende una secuencia de adn que codifica una molecula infecciosa de arn que codifica un virus prrs norteamericano, celula transfectada y vacuna

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP990106325 AR025146A1 (es) 1998-12-22 1999-12-13 UNA MOLÉCULA AISLADA DE POLINUCLEoTIDO QUE COMPRENDE UNA SECUENCIA DE ADN QUE CODIFICA UN VIRUS PRRS NORTEAMERICANO, CÉLULA HUESPED, PLÁSMIDO, MÉTODO PARA GENERAR UN VIRUS PRRS NORTEAMERICANO Y VACUNA.

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US (2) US6500662B1 (es)
EP (2) EP1018557B9 (es)
JP (7) JP4113642B2 (es)
CN (1) CN1171996C (es)
AR (2) AR025146A1 (es)
AT (1) ATE309364T1 (es)
AU (1) AU769841B2 (es)
BR (1) BRPI9905902B8 (es)
CA (2) CA2440933A1 (es)
CY (2) CY1105680T1 (es)
DE (1) DE69928209T9 (es)
DK (2) DK1627919T3 (es)
ES (2) ES2459568T3 (es)
HK (1) HK1029140A1 (es)
MX (1) MXPA03009354A (es)
NZ (2) NZ501264A (es)
PT (1) PT1627919E (es)
ZA (1) ZA997289B (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0839912A1 (en) 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
US20040224327A1 (en) * 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
WO2000053787A1 (en) * 1999-03-08 2000-09-14 Id-Lelystad, Instituut Voor Dierhouderij En Dierg Ezondheid B.V. Prrsv vaccines
US7618797B2 (en) * 1998-12-22 2009-11-17 Pfizer Inc Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7691389B2 (en) * 1998-12-22 2010-04-06 Pfizer Inc Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
JP4778620B2 (ja) 1999-04-22 2011-09-21 ユナイテッド ステイツ デパートメント オブ アグリカルチャー 分離株ｊａ−１４２に基づく、豚繁殖・呼吸障害症候群ワクチン
JPWO2002038753A1 (ja) * 2000-11-09 2004-03-18 渡辺　純一 病原体に感染した動物の病態または生存に影響を与える遺伝子のスクリーニング方法
US6841364B2 (en) * 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
US7906311B2 (en) 2002-03-20 2011-03-15 Merial Limited Cotton rat lung cells for virus culture
SI1651265T1 (sl) * 2003-07-24 2008-10-31 Merial Ltd Formulacije cepiva, ki obsegajo emulzijo olje v vodi
KR20070028547A (ko) 2004-06-18 2007-03-12 리전츠 오브 더 유니버스티 오브 미네소타 바이러스에 감염되고 백신접종된 생물의 동정
KR100872840B1 (ko) 2004-07-09 2008-12-22 (주)씨아이디 돼지생식기호흡기증후군 바이러스에 대한 전체-길이의감염성이 있는 cDNA 클론 및 이의 용도
US7632636B2 (en) 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
KR20070064666A (ko) * 2004-11-11 2007-06-21 화이자 프로덕츠 인코포레이티드 돼지의 생식 및 호흡 증후군 바이러스 돌연변이
WO2006074986A2 (en) 2005-01-13 2006-07-20 Boehringer Ingelheim Vetmedica Gmbh Prrs vaccines
KR100996105B1 (ko) * 2005-02-25 2010-11-22 화이자 프로덕츠 인크. 돼지 생식기 호흡기 증후군 바이러스의 ｎ 단백질돌연변이체
UA95778C2 (ru) * 2005-06-24 2011-09-12 Риджентс Оф Зе Юниверсити Оф Миннесота Вирусы репродуктивно-респираторного синдрома свиней, их инфекционные клоны и мутанты и способы применения
ES2343371T3 (es) * 2005-08-30 2010-07-29 Board Of Regents Of The University Of Nebraska Procedimientos y composiciones para la vacunacion de animales con antigenos de vsrrp con una inmunogenicidad mejorada.
MX2009007457A (es) 2007-01-12 2009-08-12 Univ Illinois Celulas que no son de mono para el desarrollo del virus del sindrome porcino reproductor y respiratorio (prrs).
US7666585B2 (en) 2007-06-15 2010-02-23 Protatek International, Inc. Construction of chimera PRRSV, compositions and vaccine preparations
MX2010000235A (es) * 2007-06-25 2010-08-02 Univ South Dakota Virus del sindrome respiratorio y reproductivo porcino tipo 1 norteamericano recombinante y metodos de uso.
CA2734390A1 (en) * 2008-08-25 2010-03-04 Boehringer Ingelheim Vetmedica, Inc. Vaccine against highly pathogenic porcine reproductive and respiratory syndrome (hp prrs)
US8012735B2 (en) * 2009-03-02 2011-09-06 University Of Kentucky Research Foundation Infectious cDNA clone of the modified live virus vaccine strain of Equine arteritis virus
AR078253A1 (es) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
SI2475384T1 (sl) * 2009-09-10 2016-12-30 Merial, Inc. Nove formulacije cepiva, ki obsegajo adjuvante, vsebujoče saponin
UA108902C2 (uk) * 2010-11-10 2015-06-25 Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування
KR101983980B1 (ko) 2011-02-17 2019-05-30 베링거잉겔하임베트메디카게엠베하 Ｐｒｒｓｖ의 상업적 규모의 제조 방법
KR102183276B1 (ko) 2011-02-17 2020-11-26 베링거잉겔하임베트메디카게엠베하 신규 유럽형 ｐｒｒｓｖ 스트레인
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
EP2737058A1 (en) 2011-07-29 2014-06-04 Boehringer Ingelheim Vetmedica GmbH INFECTIOUS cDNA CLONE OF EUROPEAN PRRS VIRUS AND USES THEREOF
UA114503C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv та mycoplasma hyopneumoniae
UA114504C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs
US9120859B2 (en) 2012-04-04 2015-09-01 Zoetis Services Llc Mycoplasma hyopneumoniae vaccine
MX2014013964A (es) * 2012-05-17 2015-03-04 Zoetis Llc Vacunacion eficaz contral el virus del sindrome reproductivo y respiratorio porcino (prrs) antes del destete.
CN105073130A (zh) 2013-03-15 2015-11-18 勃林格殷格翰动物保健公司 猪生殖与呼吸综合征病毒、组合物、疫苗及使用方法
CA2925281C (en) 2013-09-25 2022-05-03 Zoetis Services Llc Pcv2b divergent vaccine composition and methods of use
CA2930042C (en) * 2013-12-20 2022-06-21 Boehringer Ingelheim Vetmedica Gmbh Prrs virus variant, european prrs virus cdna clone, and uses thereof
CN104198773A (zh) * 2014-08-29 2014-12-10 苏州市吴中区胥口广博模具加工厂 三轴联动式大型电路板测试夹具的第二转轴组
TWI554609B (zh) * 2014-11-19 2016-10-21 國立屏東科技大學 抗豬生殖與呼吸綜合症病毒感染之重組融合抗原基因、重組融合抗原蛋白及含彼之次單位疫苗組成物
DK3344289T3 (da) 2015-08-31 2020-04-14 Boehringer Ingelheim Vetmedica Gmbh Pestivirusvacciner mod medfødt tremor
EP3389706A1 (en) 2015-12-14 2018-10-24 Boehringer Ingelheim Vetmedica, Inc. Hybrid core feline vaccines
JP6986078B2 (ja) 2016-08-05 2021-12-22 ヒプラ サイエンティフィック，エス．エル．ユー． ブタ生殖器呼吸器症候群ウイルスｃＤＮＡクローンおよびその用途
JP7129978B2 (ja) 2016-12-14 2022-09-02 ゾエティス・サービシーズ・エルエルシー 豚繁殖・呼吸障害症候群（ｐｒｒｓ）ウイルスの欧州株に対抗する離乳前の効果的なワクチン接種
CN107586780B (zh) * 2017-10-25 2019-10-11 中国农业科学院兰州兽医研究所 一种抑制猪繁殖与呼吸综合征病毒的长链非编码rna
CN109943590B (zh) * 2019-04-18 2022-11-18 西南大学 一种复制缺陷型猪圆环病毒、其制备方法及应用
CN111996174A (zh) * 2020-02-06 2020-11-27 广西大学 猪繁殖与呼吸综合征病毒及其克隆载体和插入基因方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3137631A (en) 1959-12-01 1964-06-16 Faberge Inc Encapsulation in natural products
US3959457A (en) 1970-06-05 1976-05-25 Temple University Microparticulate material and method of making such material
US4015100A (en) 1974-01-07 1977-03-29 Avco Everett Research Laboratory, Inc. Surface modification
JPS5186117A (en) 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4205060A (en) 1978-12-20 1980-05-27 Pennwalt Corporation Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use
US4452747A (en) 1982-03-22 1984-06-05 Klaus Gersonde Method of and arrangement for producing lipid vesicles
US4744933A (en) 1984-02-15 1988-05-17 Massachusetts Institute Of Technology Process for encapsulation and encapsulated active material system
US5008050A (en) 1984-06-20 1991-04-16 The Liposome Company, Inc. Extrusion technique for producing unilamellar vesicles
US4921706A (en) 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US4606940A (en) 1984-12-21 1986-08-19 The Ohio State University Research Foundation Small particle formation and encapsulation
US5009956A (en) 1987-02-24 1991-04-23 Univ Minnesota Phospholipase A2-resistant liposomes
IT8819772A0 (it) * 1988-03-15 1988-03-15 Honeywell Bull Spa Dispositivo selettivo a terra per apparecchiature elettroniche.
US4927637A (en) 1989-01-17 1990-05-22 Liposome Technology, Inc. Liposome extrusion method
US4944948A (en) 1989-02-24 1990-07-31 Liposome Technology, Inc. EGF/Liposome gel composition and method
US5132117A (en) 1990-01-11 1992-07-21 Temple University Aqueous core microcapsules and method for their preparation
CA2290906C (en) 1991-06-06 2003-04-01 Stichting Centraal Diergeneeskundig Instituut Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
US6042830A (en) 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
US5846805A (en) 1991-08-26 1998-12-08 Boehringer Ingelheim Animal Health, Inc. Culture of swine infertility and respiratory syndrome virus in simian cells
DE601062T1 (de) 1991-08-26 1995-05-18 James Edward Collins Vakzine gegen und diagnosemethode für das schweine-unfruchtbarkeits- und atmungs-syndrom (suas).
MX9204885A (es) 1991-08-26 1994-05-31 Boehringer Animal Health Inc Composicion de vacuna que comprende virus del sindrome de infertilidad y respiratorio de los cerdos.
AU2696792A (en) 1991-09-16 1993-04-27 David A Benfield Vaccine for mystery swine disease and method for diagnosis thereof
FR2686097B1 (fr) 1992-01-14 1994-12-30 Rhone Merieux Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie.
US5203054A (en) 1992-09-28 1993-04-20 Emhart Inc. Retainer for trunk lid torsion bars
US6592873B1 (en) 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
US5695766A (en) 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
US6251397B1 (en) * 1992-10-30 2001-06-26 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same
US6773908B1 (en) * 1992-10-30 2004-08-10 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
DE69426228T2 (de) 1993-02-08 2001-03-01 Bayer Ag Verfahren zum Vermehren des das Reproduktions- und Atemwegs-Syndrom verursachenden Schweinevirus und dessen Verwendung als Impfstoff.
ES2074950B1 (es) 1993-09-17 1996-03-16 Iberica Cyanamid Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda.
DE69530227T2 (de) 1994-04-15 2004-04-01 Temple University Methode zum einkapseln mittels eines wässrigen lösungsmittels und mikrokapseln
CA2196555C (en) * 1994-08-05 2012-07-03 Michael P. Murtaugh Vr-2332 viral nucleotide sequence and methods of use
DE69632658T2 (de) 1995-03-14 2005-06-09 Akzo Nobel N.V. Expression in der selben Zelle von Polypeptide vom schweinen reproduktiven und respiratorischen Syndrom
RU2187333C2 (ru) 1996-03-01 2002-08-20 Шеринг Корпорейшн Вакцина для защиты свиней от репродуктивного и респираторного синдрома и способ защиты свиней
EP0839912A1 (en) * 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
AU7960598A (en) 1997-06-05 1998-12-21 Origen, Inc. Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine
US6288199B1 (en) * 1999-11-02 2001-09-11 Ppg Industries Ohio, Inc. Blocked isocyanate-based compounds and compositions containing the same

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