CY1105680T1 - Μολυσματικος κλωνος cdna βορειοαμερικανικου ιου χοιρειου αναπαραγωγικου και αναπνευστικου συνδρομου (prrs) και χρησεις αυτου - Google Patents
Μολυσματικος κλωνος cdna βορειοαμερικανικου ιου χοιρειου αναπαραγωγικου και αναπνευστικου συνδρομου (prrs) και χρησεις αυτουInfo
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- CY1105680T1 CY1105680T1 CY061100160T CY061100160T CY1105680T1 CY 1105680 T1 CY1105680 T1 CY 1105680T1 CY 061100160 T CY061100160 T CY 061100160T CY 061100160 T CY061100160 T CY 061100160T CY 1105680 T1 CY1105680 T1 CY 1105680T1
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Abstract
Η εφεύρεση παρέχει απομονωμένα μόρια πολυνουκλεοτιδίων, που περιλαμβάνουν πλασμίδια, ιικούς φορείς, και διαμολυσμένα κύτταρα-ξενιστές που περιλαμβάνουν αλληλουχία DNA που κωδικοποιεί μολυσματική αλληλουχία RNA που κωδικοποιεί Βορειοαμερικανικό ιό PRRS, και επίσης Βορειοαμερικανικούς ιούς PRRS που κωδικοποιούνται από αυτά τα απομονωμένα μόρια πολυνουκλεοτιδίων. Η εφεύρεση παρέχει επιπλέον απομονωμένα μολυσματικά μόρια RNA που κωδικοποιούν Βορειοαμερικανικό ιό PRRS. Η εφεύρεση παρέχει επίσης απομονωμένα μόρια πολυνουκλεοτιδίων, μολυσματικά μόρια RNA, ιικούς φορείς, και διαμολυσμένα κύτταρα-ξενιστές που κωδικοποιούν γενετικά τροποποιημένους Βορειοαμερικανικούς ιούς PRRS, και γενετικά τροποποιημένους Βορειοαμερικανικούς ιούς PRRS που κωδικοποιούνται από αυτά τα απομονωμένα μόρια πολυνουκλεοτιδίων. Η εφεύρεση παρέχει επίσης εμβόλια που περιλαμβάνουν αυτά τα πλασμίδια, μόρια RNA, ιικούς φορείς και Βορειοαμερικανικούς ιούς PRRS, και μεθόδους χρήσης αυτών των εμβολίων σε χοιροειδή και σε άλλα ζώα. Παρέχονται επίσης απομονωμένα μόρια πολυνουκλεοτιδίων, ιικοί φορείς, και διαμολυσμένα κύτταρα-ξενιστές που περιλαμβάνουν αλληλουχία νουκλεοτιδίων που κωδικοποιεί πεπτίδιο Βορειοαμερικανικού ιού PRRS. Αυτοί οι ιικοί φορείς και κυτταρικές σειρές διαμολυσμένων κυττάρων-ξενιστών χρησιμεύουν στο να παρέχουν πεπτίδια που να αναπληρώνουν αλληλουχίες που κωδικοποιούν μεταλλαγμένα πεπτίδια των αλληλουχιών DNA που κωδικοποιούν γενετικά τροποποιημένους Βορειοαμερικανικούς ιούς PRRS έτσι ώστε να παράγονται λειτουργικά ιοσώματα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11334598P | 1998-12-22 | 1998-12-22 | |
EP19990309409 EP1018557B9 (en) | 1998-12-22 | 1999-11-25 | Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
Publications (1)
Publication Number | Publication Date |
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CY1105680T1 true CY1105680T1 (el) | 2014-07-02 |
Family
ID=22348908
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY061100160T CY1105680T1 (el) | 1998-12-22 | 2006-02-07 | Μολυσματικος κλωνος cdna βορειοαμερικανικου ιου χοιρειου αναπαραγωγικου και αναπνευστικου συνδρομου (prrs) και χρησεις αυτου |
CY20141100252T CY1115010T1 (el) | 1998-12-22 | 2014-04-03 | ΕΝΑΣ ΜΟΛΥΣΜΑΤΙΚΟΣ cDNA ΚΛΩΝΟΣ ΤΟΥ ΙΟΥ ΤΟΥ ΧΟΙΡΕΙΟΥ ΑΝΑΠΑΡΑΓΩΓΙΚΟΥ ΚΑΙ ΑΝΑΠΝΕΥΣΤΙΚΟΥ ΣΥΝΔΡΟΜΟΥ ΒΟΡΕΙΟΥ ΑΜΕΡΙΚΗΣ (PRRS) ΚΑΙ ΧΡΗΣΕΙΣ ΑΥΤΟΥ |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100252T CY1115010T1 (el) | 1998-12-22 | 2014-04-03 | ΕΝΑΣ ΜΟΛΥΣΜΑΤΙΚΟΣ cDNA ΚΛΩΝΟΣ ΤΟΥ ΙΟΥ ΤΟΥ ΧΟΙΡΕΙΟΥ ΑΝΑΠΑΡΑΓΩΓΙΚΟΥ ΚΑΙ ΑΝΑΠΝΕΥΣΤΙΚΟΥ ΣΥΝΔΡΟΜΟΥ ΒΟΡΕΙΟΥ ΑΜΕΡΙΚΗΣ (PRRS) ΚΑΙ ΧΡΗΣΕΙΣ ΑΥΤΟΥ |
Country Status (18)
Country | Link |
---|---|
US (2) | US6500662B1 (el) |
EP (2) | EP1018557B9 (el) |
JP (7) | JP4113642B2 (el) |
CN (1) | CN1171996C (el) |
AR (2) | AR025146A1 (el) |
AT (1) | ATE309364T1 (el) |
AU (1) | AU769841B2 (el) |
BR (1) | BRPI9905902B8 (el) |
CA (2) | CA2440933A1 (el) |
CY (2) | CY1105680T1 (el) |
DE (1) | DE69928209T9 (el) |
DK (2) | DK1627919T3 (el) |
ES (2) | ES2459568T3 (el) |
HK (1) | HK1029140A1 (el) |
MX (1) | MXPA03009354A (el) |
NZ (2) | NZ513289A (el) |
PT (1) | PT1627919E (el) |
ZA (1) | ZA997289B (el) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0839912A1 (en) * | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
US20040224327A1 (en) * | 1996-10-30 | 2004-11-11 | Meulenberg Johanna Jacoba Maria | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
US7691389B2 (en) * | 1998-12-22 | 2010-04-06 | Pfizer Inc | Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
US7618797B2 (en) * | 1998-12-22 | 2009-11-17 | Pfizer Inc | Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
CA2366072C (en) | 1999-03-08 | 2007-07-10 | Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. | Prrsv vaccines |
AU4482200A (en) | 1999-04-22 | 2000-11-10 | United States Department Of Agriculture | Porcine reproductive and respiratory syndrome vaccine, based on isolate ja-142 |
JPWO2002038753A1 (ja) * | 2000-11-09 | 2004-03-18 | 渡辺 純一 | 病原体に感染した動物の病態または生存に影響を与える遺伝子のスクリーニング方法 |
US6841364B2 (en) * | 2002-01-22 | 2005-01-11 | Protatek International, Inc. | Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof |
US7906311B2 (en) | 2002-03-20 | 2011-03-15 | Merial Limited | Cotton rat lung cells for virus culture |
CA2533581C (en) * | 2003-07-24 | 2012-05-08 | Merial Limited | Vaccine formulations comprising an oil-in-water emulsion |
CA2571452A1 (en) | 2004-06-18 | 2006-01-26 | Regents Of The University Of Minnesota | Identifying virally infected and vaccinated organisms |
KR100872840B1 (ko) | 2004-07-09 | 2008-12-22 | (주)씨아이디 | 돼지생식기호흡기증후군 바이러스에 대한 전체-길이의감염성이 있는 cDNA 클론 및 이의 용도 |
US7632636B2 (en) * | 2004-09-21 | 2009-12-15 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome isolates and methods of use |
BRPI0517745A (pt) * | 2004-11-11 | 2008-10-21 | Pfizer Prod Inc | vìrus mutante da sìndrome reprodutiva e respiratória de suìnos |
RU2007130801A (ru) | 2005-01-13 | 2009-02-20 | Берингер Ингельхайм Ветмедика Гмбх (De) | Улучшенные вакцины против репродуктивно-респираторного синдрома свиней (prrs) |
KR20100090311A (ko) * | 2005-02-25 | 2010-08-13 | 화이자 프로덕츠 인크. | 돼지 생식기 호흡기 증후군 바이러스의 n 단백질 돌연변이체 |
UA95778C2 (ru) * | 2005-06-24 | 2011-09-12 | Риджентс Оф Зе Юниверсити Оф Миннесота | Вирусы репродуктивно-респираторного синдрома свиней, их инфекционные клоны и мутанты и способы применения |
BRPI0615610A2 (pt) * | 2005-08-30 | 2011-05-24 | Univ Nebraska | processos e composições para vacinação de animais com antìgenos de prrsv com maior imunogenicidade |
PL2106440T3 (pl) * | 2007-01-12 | 2016-02-29 | Univ Illinois | Komórki niepochodzące od małp do hodowli wirusa zespołu rozrodczo-oddechowego świń (PRRS) |
US7666585B2 (en) | 2007-06-15 | 2010-02-23 | Protatek International, Inc. | Construction of chimera PRRSV, compositions and vaccine preparations |
ES2389748T3 (es) * | 2007-06-25 | 2012-10-31 | South Dakota State University | Virus del síndrome reproductivo y respiratorio porcino de tipo 1 norteamericano recombinante y métodos de uso |
RU2561595C2 (ru) * | 2008-08-25 | 2015-08-27 | Бёрингер Ингельхайм Ветмедика, Инк. | Вакцина против высокопатогенного репродуктивно-респираторного синдрома свиней (hp prrs) |
US8012735B2 (en) * | 2009-03-02 | 2011-09-06 | University Of Kentucky Research Foundation | Infectious cDNA clone of the modified live virus vaccine strain of Equine arteritis virus |
TWI627281B (zh) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物 |
AU2010292233B2 (en) * | 2009-09-10 | 2014-03-06 | Boehringer Ingelheim Animal Health USA Inc. | New vaccine formulations comprising saponin-containing adjuvants |
UA108902C2 (uk) * | 2010-11-10 | 2015-06-25 | Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування | |
PL2959916T3 (pl) | 2011-02-17 | 2019-05-31 | Boehringer Ingelheim Vetmedica Gmbh | Nowy europejski szczep prrsv |
JP2014506795A (ja) | 2011-02-17 | 2014-03-20 | ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Prrsvの工業規模の製造方法 |
EP2737059A1 (en) | 2011-07-29 | 2014-06-04 | Boehringer Ingelheim Vetmedica GmbH | Novel prrs virus inducing type i interferon in susceptible cells |
US9187731B2 (en) | 2011-07-29 | 2015-11-17 | Boehringer Ingelheim Vetmedica Gmbh | PRRS virus inducing type I interferon in susceptible cells |
US9120859B2 (en) | 2012-04-04 | 2015-09-01 | Zoetis Services Llc | Mycoplasma hyopneumoniae vaccine |
UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
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