DK1018557T3 - Infektiös cDNA-klon af Nordamerikansk porcint reproduktions- og respirationssyndromvirus (PRRS-virus) og anvendelser deraf - Google Patents
Infektiös cDNA-klon af Nordamerikansk porcint reproduktions- og respirationssyndromvirus (PRRS-virus) og anvendelser derafInfo
- Publication number
- DK1018557T3 DK1018557T3 DK99309409T DK99309409T DK1018557T3 DK 1018557 T3 DK1018557 T3 DK 1018557T3 DK 99309409 T DK99309409 T DK 99309409T DK 99309409 T DK99309409 T DK 99309409T DK 1018557 T3 DK1018557 T3 DK 1018557T3
- Authority
- DK
- Denmark
- Prior art keywords
- virus
- cdna clone
- north american
- respiratory syndrome
- porcine reproductive
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10041—Use of virus, viral particle or viral elements as a vector
- C12N2770/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
- C12N2770/10062—Methods of inactivation or attenuation by genetic engineering
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11334598P | 1998-12-22 | 1998-12-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1018557T3 true DK1018557T3 (da) | 2005-12-05 |
DK1018557T5 DK1018557T5 (da) | 2006-05-15 |
Family
ID=22348908
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05018141T DK1627919T3 (da) | 1998-12-22 | 1999-11-25 | INFEKTIØS cDNA-KLON AF NORDAMERIKANSK PORCINT REPRODUKTIONS- OG RESPIRATIONSSYNDROMVIRUS (PRRS) OG ANVENDELSER DERAF |
DK99309409T DK1018557T5 (da) | 1998-12-22 | 1999-11-25 | Infektiös cDNA-klon af Nordamerikansk porcint reproduktions- og respirationssyndromvirus (PRRS-virus) og anvendelser deraf |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05018141T DK1627919T3 (da) | 1998-12-22 | 1999-11-25 | INFEKTIØS cDNA-KLON AF NORDAMERIKANSK PORCINT REPRODUKTIONS- OG RESPIRATIONSSYNDROMVIRUS (PRRS) OG ANVENDELSER DERAF |
Country Status (18)
Country | Link |
---|---|
US (2) | US6500662B1 (da) |
EP (2) | EP1018557B9 (da) |
JP (7) | JP4113642B2 (da) |
CN (1) | CN1171996C (da) |
AR (2) | AR025146A1 (da) |
AT (1) | ATE309364T1 (da) |
AU (1) | AU769841B2 (da) |
BR (1) | BRPI9905902B8 (da) |
CA (2) | CA2290220C (da) |
CY (2) | CY1105680T1 (da) |
DE (1) | DE69928209T9 (da) |
DK (2) | DK1627919T3 (da) |
ES (2) | ES2251162T3 (da) |
HK (1) | HK1029140A1 (da) |
MX (1) | MXPA03009354A (da) |
NZ (2) | NZ501264A (da) |
PT (1) | PT1627919E (da) |
ZA (1) | ZA997289B (da) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0839912A1 (en) | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
US20040224327A1 (en) * | 1996-10-30 | 2004-11-11 | Meulenberg Johanna Jacoba Maria | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
US7691389B2 (en) * | 1998-12-22 | 2010-04-06 | Pfizer Inc | Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
US7618797B2 (en) * | 1998-12-22 | 2009-11-17 | Pfizer Inc | Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
AU3198200A (en) * | 1999-03-08 | 2000-09-28 | Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. | Prrsv vaccines |
ATE474041T1 (de) | 1999-04-22 | 2010-07-15 | Us Agriculture | Auf dem isolat ja-142 basierender impfstoff gegen das reproduktive-und-respiratorische syndrom beim schwein |
WO2002038753A1 (fr) * | 2000-11-09 | 2002-05-16 | Junichi Watanabe | Procede de criblage d'un gene agissant sur les conditions pathologiques ou la survie d'un animal infecte par un pathogene |
US6841364B2 (en) | 2002-01-22 | 2005-01-11 | Protatek International, Inc. | Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof |
US7906311B2 (en) * | 2002-03-20 | 2011-03-15 | Merial Limited | Cotton rat lung cells for virus culture |
EP1651265B1 (en) * | 2003-07-24 | 2008-04-23 | Merial Limited | Vaccine formulations comprising an oil-in-water emulsion |
KR20070028547A (ko) | 2004-06-18 | 2007-03-12 | 리전츠 오브 더 유니버스티 오브 미네소타 | 바이러스에 감염되고 백신접종된 생물의 동정 |
KR100872840B1 (ko) | 2004-07-09 | 2008-12-22 | (주)씨아이디 | 돼지생식기호흡기증후군 바이러스에 대한 전체-길이의감염성이 있는 cDNA 클론 및 이의 용도 |
US7632636B2 (en) * | 2004-09-21 | 2009-12-15 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome isolates and methods of use |
KR20070064666A (ko) * | 2004-11-11 | 2007-06-21 | 화이자 프로덕츠 인코포레이티드 | 돼지의 생식 및 호흡 증후군 바이러스 돌연변이 |
KR20070096019A (ko) | 2005-01-13 | 2007-10-01 | 베링거잉겔하임베트메디카게엠베하 | 향상된 prrs 백신 |
WO2006129139A1 (en) * | 2005-02-25 | 2006-12-07 | Pfizer Products Inc. | N protein mutants of porcine reproductive and respiratory syndrome virus |
CA2894069C (en) | 2005-06-24 | 2019-02-26 | Regents Of The University Of Minnesota | Prrs viruses, infectious clones, mutants thereof, and methods of use |
DE602006013003D1 (de) * | 2005-08-30 | 2010-04-29 | Univ Nebraska | Verfahren und zusammensetzungen zur impfung von tieren mit prrsv-antigenen mit verbesserter immunogenität |
US8202717B2 (en) * | 2007-01-12 | 2012-06-19 | The Board Of Trustees Of The University Of Illinois | Non-simian cells for growth of porcine reproductive and respiratory syndrome (PRRS) virus |
US7666585B2 (en) | 2007-06-15 | 2010-02-23 | Protatek International, Inc. | Construction of chimera PRRSV, compositions and vaccine preparations |
CA2691755A1 (en) * | 2007-06-25 | 2008-12-31 | South Dakota State University | Recombinant north american type 1 porcine reproductive and respiratory syndrome virus and methods of use |
RU2561595C2 (ru) * | 2008-08-25 | 2015-08-27 | Бёрингер Ингельхайм Ветмедика, Инк. | Вакцина против высокопатогенного репродуктивно-респираторного синдрома свиней (hp prrs) |
US8012735B2 (en) * | 2009-03-02 | 2011-09-06 | University Of Kentucky Research Foundation | Infectious cDNA clone of the modified live virus vaccine strain of Equine arteritis virus |
TWI627281B (zh) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物 |
PL2475384T3 (pl) * | 2009-09-10 | 2017-02-28 | Merial, Inc. | Nowe formulacje szczepionek obejmujące adiuwanty zawierające saponiny |
UA108902C2 (uk) * | 2010-11-10 | 2015-06-25 | Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування | |
US8765142B2 (en) | 2011-02-17 | 2014-07-01 | Boehringer Ingelheim Vetmedica Gmbh | European PRRSV strain |
BR112013020966B1 (pt) | 2011-02-17 | 2020-05-26 | Boehringer Ingelheim Vetmedica Gmbh | Processo em escala comercial para produção do prrsv |
US9187731B2 (en) | 2011-07-29 | 2015-11-17 | Boehringer Ingelheim Vetmedica Gmbh | PRRS virus inducing type I interferon in susceptible cells |
WO2013017570A1 (en) | 2011-07-29 | 2013-02-07 | Boehringer Ingelheim Vetmedica Gmbh | Novel prrs virus inducing type i interferon in susceptible cells |
UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
UA114503C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
US9120859B2 (en) | 2012-04-04 | 2015-09-01 | Zoetis Services Llc | Mycoplasma hyopneumoniae vaccine |
JP6386999B2 (ja) | 2012-05-17 | 2018-09-05 | ゾエティス・エルエルシー | ブタ生殖および呼吸症候群(prrs)ウイルスに対する離乳前の効果的なワクチン接種 |
CN105073130A (zh) | 2013-03-15 | 2015-11-18 | 勃林格殷格翰动物保健公司 | 猪生殖与呼吸综合征病毒、组合物、疫苗及使用方法 |
KR20160046879A (ko) | 2013-09-25 | 2016-04-29 | 조에티스 서비시즈 엘엘씨 | Pcv2b 분지형 백신 조성물 및 사용 방법 |
MX2016007737A (es) | 2013-12-20 | 2016-09-07 | Boehringer Ingelheim Vetmedica Gmbh | Variante del virus prrs, clon de adnc del virus europeo y sus usos. |
CN104198773A (zh) * | 2014-08-29 | 2014-12-10 | 苏州市吴中区胥口广博模具加工厂 | 三轴联动式大型电路板测试夹具的第二转轴组 |
TWI554609B (zh) | 2014-11-19 | 2016-10-21 | 國立屏東科技大學 | 抗豬生殖與呼吸綜合症病毒感染之重組融合抗原基因、重組融合抗原蛋白及含彼之次單位疫苗組成物 |
US9920302B2 (en) | 2015-08-31 | 2018-03-20 | Boehringer Ingelheim Vetmedica Gmbh | Pestivirus vaccines for congenital tremors |
US10188725B2 (en) | 2015-12-14 | 2019-01-29 | Elanco Us Inc. | Hybrid core feline vaccines |
BR112019000887A2 (pt) | 2016-08-05 | 2019-04-30 | Hipra Scientific, S.L.U. | clone de cdna do vírus da síndrome reprodutiva e respiratória porcina e usos do mesmo |
BR112019012158A2 (pt) | 2016-12-14 | 2019-11-12 | Zoetis Services Llc | vacinação eficaz contra cepas europeias de vírus da síndrome reprodutiva e respiratória suína (prrs) antes do desmame |
CN107586780B (zh) * | 2017-10-25 | 2019-10-11 | 中国农业科学院兰州兽医研究所 | 一种抑制猪繁殖与呼吸综合征病毒的长链非编码rna |
CN109943590B (zh) * | 2019-04-18 | 2022-11-18 | 西南大学 | 一种复制缺陷型猪圆环病毒、其制备方法及应用 |
CN111996174A (zh) * | 2020-02-06 | 2020-11-27 | 广西大学 | 猪繁殖与呼吸综合征病毒及其克隆载体和插入基因方法 |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3137631A (en) | 1959-12-01 | 1964-06-16 | Faberge Inc | Encapsulation in natural products |
US3959457A (en) | 1970-06-05 | 1976-05-25 | Temple University | Microparticulate material and method of making such material |
US4015100A (en) | 1974-01-07 | 1977-03-29 | Avco Everett Research Laboratory, Inc. | Surface modification |
JPS5186117A (en) | 1975-01-27 | 1976-07-28 | Tanabe Seiyaku Co | Johoseibiryushiseizainoseiho |
US4205060A (en) | 1978-12-20 | 1980-05-27 | Pennwalt Corporation | Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use |
US4452747A (en) | 1982-03-22 | 1984-06-05 | Klaus Gersonde | Method of and arrangement for producing lipid vesicles |
US4744933A (en) | 1984-02-15 | 1988-05-17 | Massachusetts Institute Of Technology | Process for encapsulation and encapsulated active material system |
US5008050A (en) | 1984-06-20 | 1991-04-16 | The Liposome Company, Inc. | Extrusion technique for producing unilamellar vesicles |
US4921706A (en) | 1984-11-20 | 1990-05-01 | Massachusetts Institute Of Technology | Unilamellar lipid vesicles and method for their formation |
US4606940A (en) | 1984-12-21 | 1986-08-19 | The Ohio State University Research Foundation | Small particle formation and encapsulation |
US5009956A (en) | 1987-02-24 | 1991-04-23 | Univ Minnesota | Phospholipase A2-resistant liposomes |
IT8819772A0 (it) * | 1988-03-15 | 1988-03-15 | Honeywell Bull Spa | Dispositivo selettivo a terra per apparecchiature elettroniche. |
US4927637A (en) | 1989-01-17 | 1990-05-22 | Liposome Technology, Inc. | Liposome extrusion method |
US4944948A (en) | 1989-02-24 | 1990-07-31 | Liposome Technology, Inc. | EGF/Liposome gel composition and method |
US5132117A (en) | 1990-01-11 | 1992-07-21 | Temple University | Aqueous core microcapsules and method for their preparation |
UA27788C2 (uk) | 1991-06-06 | 2000-10-16 | Стіхтінг Сентрал Діргенескюндіг Інстітют | Композиція, що містить виділений фактор лелістада, вакцинна композиція для вакцинації тварин (варіанти), діагностичний набір для виявлення антитіла |
US5846805A (en) | 1991-08-26 | 1998-12-08 | Boehringer Ingelheim Animal Health, Inc. | Culture of swine infertility and respiratory syndrome virus in simian cells |
US6042830A (en) | 1992-08-05 | 2000-03-28 | Boehringer Ingelheim Vetmedica, Inc. | Viral agent associated with mystery swine disease |
ES2065303T5 (es) | 1991-08-26 | 2001-05-01 | Univ Minnesota | Procedimiento de diagnosis y vacuna especifica. |
MX9204885A (es) | 1991-08-26 | 1994-05-31 | Boehringer Animal Health Inc | Composicion de vacuna que comprende virus del sindrome de infertilidad y respiratorio de los cerdos. |
WO1993006211A1 (en) | 1991-09-16 | 1993-04-01 | Collins James E | Vaccine for mystery swine disease and method for diagnosis thereof |
FR2686097B1 (fr) | 1992-01-14 | 1994-12-30 | Rhone Merieux | Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie. |
US5203054A (en) | 1992-09-28 | 1993-04-20 | Emhart Inc. | Retainer for trunk lid torsion bars |
US5695766A (en) | 1992-10-30 | 1997-12-09 | Iowa State University Research Foundation | Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome |
US6251397B1 (en) * | 1992-10-30 | 2001-06-26 | Iowa State University Research Foundation, Inc. | Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same |
US6592873B1 (en) | 1992-10-30 | 2003-07-15 | Iowa State University Research Foundation, Inc. | Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids |
US6773908B1 (en) * | 1992-10-30 | 2004-08-10 | Iowa State University Research Foundation, Inc. | Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV) |
KR100374295B1 (ko) | 1993-02-08 | 2003-12-24 | 바이엘 코포레이션 | 돼지생식및호흡증후군바이러스의생육방법과백신에서그의용도 |
ES2074950B1 (es) | 1993-09-17 | 1996-03-16 | Iberica Cyanamid | Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda. |
DE69530227T2 (de) | 1994-04-15 | 2004-04-01 | Temple University | Methode zum einkapseln mittels eines wässrigen lösungsmittels und mikrokapseln |
MX9700817A (es) * | 1994-08-05 | 1997-05-31 | Univ Minnesota | Secuencia viral de nucleotidos de "vr-2332" y metodos de uso. |
DE69632658T2 (de) | 1995-03-14 | 2005-06-09 | Akzo Nobel N.V. | Expression in der selben Zelle von Polypeptide vom schweinen reproduktiven und respiratorischen Syndrom |
CO4600644A1 (es) | 1996-03-01 | 1998-05-08 | Schering Corp | Vacuna contra el sindrome reproductivo y respiratorio porcino |
EP0839912A1 (en) | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
WO1998055626A2 (en) | 1997-06-05 | 1998-12-10 | Origen, Inc. | Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine |
US6288199B1 (en) * | 1999-11-02 | 2001-09-11 | Ppg Industries Ohio, Inc. | Blocked isocyanate-based compounds and compositions containing the same |
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1999
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