DK1627919T3 - INFEKTIØS cDNA-KLON AF NORDAMERIKANSK PORCINT REPRODUKTIONS- OG RESPIRATIONSSYNDROMVIRUS (PRRS) OG ANVENDELSER DERAF - Google Patents
INFEKTIØS cDNA-KLON AF NORDAMERIKANSK PORCINT REPRODUKTIONS- OG RESPIRATIONSSYNDROMVIRUS (PRRS) OG ANVENDELSER DERAF Download PDFInfo
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- DK1627919T3 DK1627919T3 DK05018141T DK05018141T DK1627919T3 DK 1627919 T3 DK1627919 T3 DK 1627919T3 DK 05018141 T DK05018141 T DK 05018141T DK 05018141 T DK05018141 T DK 05018141T DK 1627919 T3 DK1627919 T3 DK 1627919T3
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Claims (7)
1
1. Isoleret polynukleotidmolekyle, som omfatter en DNA-sekvens, som koder for et infektiøst RNA-molekyle, hvor DNA-sekvensen er mindst 85 % identisk 5 med sekvensen ifølge SEQ ID N0.1.
2. Isoleret infektiøst RNA-molekyle, der kodes for af et isoleret polynukleotidmolekyle ifølge krav 1, hvilket infektiøse RNA-molekyle koder for et nordamerikansk PRRS-virus. 10
3. Isoleret polynukleotidmolekyle ifølge krav 1 i form af et plasmid.
4. Transficeret værtscelle, der omfatter en DNA-sekvens, som koder for et infektiøst RNA-molekyle, hvor DNA-sekvensen er mindst 85 % identisk med 15 sekvensen ifølge SEQ ID N0.1.
5. Plasmid, der er i stand til direkte at transficere en egnet værtscelle og udtrykke en Nidovirales virus fra den egnede således transficerede værtscelle, hvilket plasmid omfatter a) en DNA-sekvens, der koder for et 20 infektiøst RNA-molekyle, der koder for Nidovirales virus, hvor DNA- sekvensen har en sekvens med mindst 85 % sekvensidentitet med sekvensen ifølge SEQ ID NO: 1, og b) en promotor, som er i stand til at transkribere det infektiøse RNA-molekyle i den egnede værtscelle.
6. Fremgangsmåde til generering af en Nidovirales virus, hvilken fremgangs måde omfatter transfektion af en egnet værtscelle med et plasmid ifølge krav 5 og opnåelse af virus genereret af den transficerede værtscelle.
7. Isoleret polynukleotidmolekyle, der omfatter en DNA-sekvens, som koder 30 for et infektiøst RNA-molekyle, som koder for en nordamerikansk PRRS- virus, som er genetisk modificeret, således at det mangler en detekterbar antigen epitop, hvor DNA-sekvensen er mindst 85 % identisk med sekvensen ifølge SEQ ID NO. 1, men mangler en eller flere DNA-sekvenser, der koder for en detekterbar antigen epitop. 35
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11334598P | 1998-12-22 | 1998-12-22 | |
EP19990309409 EP1018557B9 (en) | 1998-12-22 | 1999-11-25 | Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1627919T3 true DK1627919T3 (da) | 2014-03-10 |
Family
ID=22348908
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05018141T DK1627919T3 (da) | 1998-12-22 | 1999-11-25 | INFEKTIØS cDNA-KLON AF NORDAMERIKANSK PORCINT REPRODUKTIONS- OG RESPIRATIONSSYNDROMVIRUS (PRRS) OG ANVENDELSER DERAF |
DK99309409T DK1018557T5 (da) | 1998-12-22 | 1999-11-25 | Infektiös cDNA-klon af Nordamerikansk porcint reproduktions- og respirationssyndromvirus (PRRS-virus) og anvendelser deraf |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99309409T DK1018557T5 (da) | 1998-12-22 | 1999-11-25 | Infektiös cDNA-klon af Nordamerikansk porcint reproduktions- og respirationssyndromvirus (PRRS-virus) og anvendelser deraf |
Country Status (18)
Country | Link |
---|---|
US (2) | US6500662B1 (da) |
EP (2) | EP1627919B1 (da) |
JP (7) | JP4113642B2 (da) |
CN (1) | CN1171996C (da) |
AR (2) | AR025146A1 (da) |
AT (1) | ATE309364T1 (da) |
AU (1) | AU769841B2 (da) |
BR (1) | BRPI9905902B8 (da) |
CA (2) | CA2290220C (da) |
CY (2) | CY1105680T1 (da) |
DE (1) | DE69928209T9 (da) |
DK (2) | DK1627919T3 (da) |
ES (2) | ES2459568T3 (da) |
HK (1) | HK1029140A1 (da) |
MX (1) | MXPA03009354A (da) |
NZ (2) | NZ513289A (da) |
PT (1) | PT1627919E (da) |
ZA (1) | ZA997289B (da) |
Families Citing this family (46)
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EP0839912A1 (en) * | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
US20040224327A1 (en) * | 1996-10-30 | 2004-11-11 | Meulenberg Johanna Jacoba Maria | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
US7691389B2 (en) * | 1998-12-22 | 2010-04-06 | Pfizer Inc | Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
US7618797B2 (en) * | 1998-12-22 | 2009-11-17 | Pfizer Inc | Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
PL204373B1 (pl) | 1999-03-08 | 2010-01-29 | Boehringer Ingelheim Vetemendi | Replikony zespołu reprodukcyjnego i oddechowego świń (PRRSV), zastosowanie replikonów PRRSV, szczepionki zawierające replikony PRRSV i zastosowanie tych szczepionek |
JP4778620B2 (ja) | 1999-04-22 | 2011-09-21 | ユナイテッド ステイツ デパートメント オブ アグリカルチャー | 分離株ja−142に基づく、豚繁殖・呼吸障害症候群ワクチン |
JPWO2002038753A1 (ja) * | 2000-11-09 | 2004-03-18 | 渡辺 純一 | 病原体に感染した動物の病態または生存に影響を与える遺伝子のスクリーニング方法 |
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KR100872840B1 (ko) | 2004-07-09 | 2008-12-22 | (주)씨아이디 | 돼지생식기호흡기증후군 바이러스에 대한 전체-길이의감염성이 있는 cDNA 클론 및 이의 용도 |
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AU2006253891B2 (en) * | 2005-02-25 | 2011-12-01 | Zoetis P Llc | N Protein Mutants of Porcine reproductive and respiratory syndrome virus |
ES2386973T3 (es) | 2005-06-24 | 2012-09-10 | Regents Of The University Of Minnesota | Virus PRRS, clones infecciosos, mutantes de los mismos, y métodos de utilización |
CA2620667A1 (en) * | 2005-08-30 | 2007-04-12 | Board Of Regents Of The University Of Nebraska | Methods and compositions for vaccination of animals with prrsv antigens with improved immunogenicity |
CN101668846B (zh) | 2007-01-12 | 2014-03-12 | 伊利诺伊大学评议会 | 用于猪繁殖与呼吸综合征(prrs)病毒生长的非猿猴细胞 |
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CN101848995A (zh) * | 2007-06-25 | 2010-09-29 | 南达科他州立大学 | 重组的北美1型猪繁殖与呼吸综合征病毒及使用方法 |
CA2734390A1 (en) * | 2008-08-25 | 2010-03-04 | Boehringer Ingelheim Vetmedica, Inc. | Vaccine against highly pathogenic porcine reproductive and respiratory syndrome (hp prrs) |
US8012735B2 (en) * | 2009-03-02 | 2011-09-06 | University Of Kentucky Research Foundation | Infectious cDNA clone of the modified live virus vaccine strain of Equine arteritis virus |
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BR112017028224A2 (pt) | 2015-08-31 | 2018-09-11 | Boehringer Ingelheim Vetmedica Gmbh | composição, e, método para proteger um leitão contra uma doença associada a pestivírus. |
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BR112019000887A2 (pt) | 2016-08-05 | 2019-04-30 | Hipra Scientific, S.L.U. | clone de cdna do vírus da síndrome reprodutiva e respiratória porcina e usos do mesmo |
CN110072547B (zh) | 2016-12-14 | 2024-04-30 | 硕腾服务有限责任公司 | 断奶前对抗欧洲猪繁殖与呼吸综合征(prrs)病毒株的有效疫苗接种 |
CN107586780B (zh) * | 2017-10-25 | 2019-10-11 | 中国农业科学院兰州兽医研究所 | 一种抑制猪繁殖与呼吸综合征病毒的长链非编码rna |
CN109943590B (zh) * | 2019-04-18 | 2022-11-18 | 西南大学 | 一种复制缺陷型猪圆环病毒、其制备方法及应用 |
CN111996174A (zh) * | 2020-02-06 | 2020-11-27 | 广西大学 | 猪繁殖与呼吸综合征病毒及其克隆载体和插入基因方法 |
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