DK2675475T3 - Ny europæisk prrsv-stamme - Google Patents
Ny europæisk prrsv-stamme Download PDFInfo
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- DK2675475T3 DK2675475T3 DK12704409.7T DK12704409T DK2675475T3 DK 2675475 T3 DK2675475 T3 DK 2675475T3 DK 12704409 T DK12704409 T DK 12704409T DK 2675475 T3 DK2675475 T3 DK 2675475T3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
- C12N2770/10064—Methods of inactivation or attenuation by serial passage
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10071—Demonstrated in vivo effect
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Claims (21)
1. Porcint reproduktions- og respiratorisk syndrom-virus (PRRSV) af en europæisk type, som er af stammen deponeret hos European Collection of Cell Cultures (ECACC) under Accessionsnummeret ECACC 11012501.
2. Porcint reproduktions- og respiratorisk syndrom-virus (PRRSV) af en europæisk type, som er af stammen deponeret hos European Collection of Cell Cultures (ECACC) under accessionsnummer ECACC 11012502.
3. PRRSV ifølge krav 2, hvor virusset er svækket ved passage mindst 36 gange i cellekultur således, at når det modificerede virus indgives til et svin eller andre pattedyr udsat for PRRSV, fejler det i at forårsage kliniske tegn på PRRSV sygdom, men er i stand til at at inducere et immunrespons, som immuniserer pattedyret mod patogene former af PRRSV.
4. Fremgangsmåde til fremstilling af den levende svækkede PRRSV ifølge krav 2, omfattende at tilpasse en MA 104-dyrket PRRSV af en europæisk type ifølge krav 1 til ikke-MA 104 mammalske celler.
5. Vaccine til beskyttelsen af svin mod PRRSV-infektion, omfattende den levende svækkede PRRSV ifølge krav 2 og en farmaceutisk acceptabel bærer.
6. Vaccine ifølge krav 5, som yderligere omfatter én eller flere ikke-PRRSV svækkede eller inaktiverede patogener eller antigent materiale deraf.
7. Vaccine ifølge krav 6, hvor de ikke-PRRSV patogener er valgt blandt Pseudorabies virus, Porcint influenza virus, Porcint parvovirus, overførbar gastroenteritis-virus, Escherichia coli, Erysipelo rhusiopathiae, Bordetella bronchiseptica, Salmonella cholerasuis, Haemophilus parasuis, Pasteurella multocida, Streptococcus suis, Mycoplasma hyopneumoniae og Actinobacillus pleuropneumoniae.
8. Vaccine ifølge krav 5 som yderligere omfatter én eller flere yderligere europæiske PRRSV-stammer valgt fra gruppen bestående af en PRRSV-stamme deponeret under accessionsnumrene Lelystad virus-stamme (Lelystad Middel (CDI-NL-2.91) eller andre stammer såsom dem, som er deponeret under accessionsnumrene ECACC 04102703, ECACC 04102702, ECACC 04102704, CNCM accessions-nr. 1-1140, CNCM accessions-nr. I-1387, CNCM accessions-nr. 1-1388, ATCC VR 2332, VR 2385, VR 2386, VR 2429, VR 2474, og VR 2402; CNCM 1-1102, CNCM 1-1140, CNCM 1-1387, CNCM 1-1388 eller ECACC V93070108 eller en U.S.-stamme såsom nordamerikansk PRRS-virus, pT7P129A; ATCC deponering VR-2332, ATCC deponering VR-2368; ATCC VR-2495; ATCC VR-2385, ATCC VR-2386, ATCC VR-2429, ATCC VR-2474, og ATCC VR-2402.
9. Vaccine ifølge krav 5, som omfatter en bærer, der er egnet til intradermal eller in-tramuskulær applikation.
10. Vaccine ifølge krav 5, som er i frysetørret form.
11. Vaccine ifølge krav 5, hvor vaccinen omfatter mindst 107 viruspartikler.
12. Fremgangsmåde til fremstilling af en levende svækket vaccine til bekæmpelse af PRRS, omfattende at iblande en levende svækket PRRSV ifølge krav 2 med en farmaceutisk acceptabel bærer.
13. Fremgangsmåde ifølge krav 12, hvor det levende svækkede PRRSV yderligere omfatter én eller flere yderligere europæiske PRRSV-stammer valgt fra gruppen bestående af en PRRSV-stamme deponeret under accessionsnumrene ECACC 04102703, ECACC 04102702, ECACC 04102704, CNCM accession-nr. 1-1140, CNCM accession-nr. 1-1387 og CNCM accession-nr. 1-1388.
14. Fremgangsmåde ifølge krav 12, hvor det levende svækkede PRRSV yderligere omfatter et adjuvans.
15. Vaccine ifølge et hvilket som helst af krav 5 til 11, til anvendelse i en fremgangsmåde til immunisering af svin mod porcint reproduktions- og respiratorisk syndrom (PRRS).
16. Vaccine til anvendelse ifølge krav 15, hvor svinet ingen lungelæsioner frembyder efter vaccination.
17. PRRS-virus, der har en nukleotidsekvens, som er mindst 95% homolog med sekvensen anført i enten SEQ ID NO:l eller SEQ ID NO:10.
18. PRRS-virus ifølge krav 17, der har en nukleotidsekvens, som er anført i enten SEQ ID NO:l eller SEQ ID NO: 10.
19. Vaccine til beskyttelsen af svin mod PRRSV-infektion, omfattende et PRRS-virus ifølge krav 17 eller 18 og en farmaceutisk acceptabel bærer, hvor PRRS-virusset har en nukleotidsekvens som er anført i SEQ ID NO: 1 eller er et svækket PRRS-virus, som har en nukleotidsekvens, som er mindst 95% homolog med sekvensen anført i SEQ ID NO:l.
20. Vaccine ifølge krav 19, som yderligere omfatter én eller flere ikke-PRRSV svækkede eller inaktiverede patogener eller antigent materiale deraf.
21. Vaccine ifølge krav 20, hvor de ikke-PRRSV pathogener er valgt blandt Pseudora-bies virus, Porcine influenza virus, Porcint parvovirus, overførbar gastroenteritis-virus, Escherichia coli, Erysipelo rhusiopathiae, Bordetella bronchiseptica, Salmonella cholerasuis, Haemophilus parasuis, Pasteurella multocida, Streptococcus suis, Mycoplasma hyopneu-moniae og Actinobacillus pleuropneumoniae.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161444074P | 2011-02-17 | 2011-02-17 | |
| PCT/EP2012/052475 WO2012110489A2 (en) | 2011-02-17 | 2012-02-14 | Novel european prrsv strain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2675475T3 true DK2675475T3 (da) | 2015-09-14 |
Family
ID=45614840
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15174330.9T DK2959916T3 (da) | 2011-02-17 | 2012-02-14 | Ny europæisk PRRSV-stamme. |
| DK12704409.7T DK2675475T3 (da) | 2011-02-17 | 2012-02-14 | Ny europæisk prrsv-stamme |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15174330.9T DK2959916T3 (da) | 2011-02-17 | 2012-02-14 | Ny europæisk PRRSV-stamme. |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US8765142B2 (da) |
| EP (2) | EP2959916B1 (da) |
| JP (1) | JP5788027B2 (da) |
| KR (2) | KR102073075B1 (da) |
| CN (2) | CN103370078B (da) |
| AR (2) | AR085272A1 (da) |
| AU (2) | AU2012217169B2 (da) |
| BR (2) | BR112013021076B1 (da) |
| CA (1) | CA2826341C (da) |
| CL (1) | CL2013002379A1 (da) |
| CO (1) | CO6791570A2 (da) |
| CY (1) | CY1116835T1 (da) |
| DK (2) | DK2959916T3 (da) |
| EA (2) | EA038012B1 (da) |
| ES (2) | ES2550258T3 (da) |
| HR (1) | HRP20151031T1 (da) |
| HU (1) | HUE027731T2 (da) |
| ME (1) | ME02271B (da) |
| MX (2) | MX355058B (da) |
| MY (2) | MY161198A (da) |
| PH (1) | PH12017500962A1 (da) |
| PL (2) | PL2675475T3 (da) |
| PT (2) | PT2959916T (da) |
| RS (1) | RS54231B1 (da) |
| SG (1) | SG192820A1 (da) |
| SI (1) | SI2675475T1 (da) |
| SM (1) | SMT201500236B (da) |
| TW (2) | TWI665303B (da) |
| UA (2) | UA112768C2 (da) |
| WO (1) | WO2012110489A2 (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2675475T3 (pl) | 2011-02-17 | 2015-12-31 | Boehringer Ingelheim Vetmedica Gmbh | Nowy europejski szczep prrs |
| US9944902B2 (en) | 2011-02-17 | 2018-04-17 | Boehringer Ingelheim Vetmedica Gmbh | Commercial scale process for production of PRRSV |
| US8906385B2 (en) | 2011-12-01 | 2014-12-09 | University Of Maryland, College Park | Interferon-inducing porcine reproductive and respiratory syndrome virus isolate |
| WO2013173443A1 (en) | 2012-05-17 | 2013-11-21 | Zoetis Llc | Effective vaccination against porcine reproductive and respiratory syndrome (prrs) virus prior to weaning |
| US9314519B2 (en) | 2012-08-21 | 2016-04-19 | Intervet Inc. | Liquid stable virus vaccines |
| US9457073B2 (en) * | 2012-09-26 | 2016-10-04 | University Of Manitoba | Live attenuated replication-competent arteriviruses having decreased dub/deisgylating activity |
| CN105308178B (zh) | 2012-12-07 | 2019-06-07 | 伊利诺伊大学评议会 | 猪繁殖与呼吸综合征病毒组合物及其用途 |
| US9393298B2 (en) | 2013-03-15 | 2016-07-19 | Intervet Inc. | Liquid stable bovine virus vaccines |
| US9480739B2 (en) | 2013-03-15 | 2016-11-01 | Intervet Inc. | Bovine virus vaccines that are liquid stable |
| AR097762A1 (es) | 2013-09-27 | 2016-04-13 | Intervet Int Bv | Formulaciones secas de vacunas que son estables a temperatura ambiente |
| MX2020010248A (es) | 2013-12-20 | 2020-10-16 | Boehringer Ingelheim Vetmedica Gmbh | Variante del virus prrs, clon de adnc del virus europeo y sus usos. |
| US10280199B2 (en) | 2014-02-07 | 2019-05-07 | Phibro Animal Health Corporation | Coronavirus proteins and antigens |
| AR099470A1 (es) | 2014-02-17 | 2016-07-27 | Intervet Int Bv | Vacunas de virus de aves de corral líquidas |
| TWI670085B (zh) * | 2014-02-19 | 2019-09-01 | 荷蘭商英特威國際公司 | 液體穩定之豬病毒疫苗 |
| PT3212182T (pt) * | 2014-10-27 | 2019-07-29 | Pharmacosmos Holding As | Tratamento ou prevenção da anemia em mamíferos não humanos em período de gestação e ninhada |
| CN106924726B (zh) * | 2015-12-29 | 2021-02-09 | 普莱柯生物工程股份有限公司 | 一种用于预防猪繁殖与呼吸综合征的疫苗组合物及其制备方法和应用 |
| WO2017196318A1 (en) * | 2016-05-11 | 2017-11-16 | Phibro Animal Health Corporation | A composition comprising antigens and a mucosal adjuvant and a method for using |
| US10279031B2 (en) | 2016-05-11 | 2019-05-07 | Phibro Animal Health Corporation | Composition comprising antigens and a mucosal adjuvant and a method for using |
| DK3534939T3 (da) | 2016-11-03 | 2023-04-24 | Boehringer Ingelheim Vetmedica Gmbh | Vaccine mod porcin parvovirus og porcin reproduktions- og respirationssyndromvirus og fremgangsmåder til fremstilling deraf |
| BR112019012158A2 (pt) * | 2016-12-14 | 2019-11-12 | Zoetis Services Llc | vacinação eficaz contra cepas europeias de vírus da síndrome reprodutiva e respiratória suína (prrs) antes do desmame |
| US11013796B2 (en) | 2018-08-30 | 2021-05-25 | Iowa State University Research Foundation, Inc. | Porcine parainfluenza virus type 1 isolates and immunogenic compositions therefrom |
| US11701419B2 (en) | 2019-04-04 | 2023-07-18 | Boehringer Ingelheim Animal Health USA Inc. | Porcine Circovirus Type 3 (PCV3) vaccines, and production and uses thereof |
| CN110735005B (zh) * | 2019-11-26 | 2023-01-10 | 广西大学 | Siv和prrsv多重rt-pcr快速检测试剂盒及引物 |
| CN111676247A (zh) * | 2020-06-30 | 2020-09-18 | 扬州大学 | 一株猪繁殖与呼吸综合征病毒1型分离株感染性克隆构建、拯救与应用 |
| BR112023001324A2 (pt) | 2020-07-24 | 2023-02-14 | Boehringer Ingelheim Animal Health Usa Inc | Combinação de vacina de suíno |
| CN113862230B (zh) * | 2021-09-30 | 2023-08-08 | 中牧实业股份有限公司 | 一种猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用 |
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