AR049924A1 - Identificacion de organismos viralmente infectados y vacunados - Google Patents

Identificacion de organismos viralmente infectados y vacunados

Info

Publication number
AR049924A1
AR049924A1 ARP050102514A ARP050102514A AR049924A1 AR 049924 A1 AR049924 A1 AR 049924A1 AR P050102514 A ARP050102514 A AR P050102514A AR P050102514 A ARP050102514 A AR P050102514A AR 049924 A1 AR049924 A1 AR 049924A1
Authority
AR
Argentina
Prior art keywords
polypeptide
prrs virus
antibody
complex
amino acid
Prior art date
Application number
ARP050102514A
Other languages
English (en)
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota filed Critical Univ Minnesota
Publication of AR049924A1 publication Critical patent/AR049924A1/es

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Abstract

Reivindicacion 1: Un kit para detectar un anticuerpo anti-virus PRRS porcino, comprendiendo dicho kit: a) un polipéptido que tiene una secuencia de aminoácidos presente en un polipéptido del virus PRRS seleccionado del grupo formado por polipéptido NSP 2 y polipéptidos ORF 5, en donde dicho polipéptido comprende un epítopo para dicho anticuerpo anti-virus PRRS porcino; y b) un anticuerpo anti-Ig porcina. Reivindicacion 2: El kit de acuerdo con la reivindicacion 1, en donde dicho polipéptido tiene por lo menos ocho residuos aminoácidos de longitud. Reivindicacion 19: Un método para determinar si una muestra contiene o no un anticuerpo anti-virus PRRS porcino, en donde dicho método comprende: a) contactar un polipéptido con dicha muestra bajo condiciones en donde dicho polipéptido forma un complejo de polipéptido:anticuerpo anti-virus PRRS porcino con un anticuerpo, si está presente, dentro de dicha muestra, en donde dicho polipéptido contiene una secuencia de aminoácidos presente en un polipéptido del virus PRRS seleccionado del grupo formado por los polipéptidos NSP 2 y los polipéptidos ORF 5, en donde dicho polipéptido comprende un epítopo para dicho anticuerpo anti-virus PRRS porcino; y b) detectar la presencia o ausencia de dicho complejo, en donde la presencia de dicho complejo indica que dicha muestra contiene dicho anticuerpo anti-virus PRRS porcino. Reivindicacion 48: Un polipéptido sustancialmente puro que tiene la secuencia de aminoácidos de un polipéptido NSP 1 del virus PRRS o un fragmento de dicho polipéptido NSP 1 del virus PRRS, en donde dicho fragmento es superior a 20 residuos aminoácidos de longitud. Reivindicacion 49: Un polipéptido sustancialmente puro que tiene la secuencia de aminoácidos de un polipéptido NSP 2 del virus PRRS o un fragmento de dicho polipéptido NSP 2 del virus PRRS, en donde dicho fragmento es superior a 20 residuos aminoácidos de longitud. Reivindicacion 50: Un polipéptido sustancialmente puro que tiene la secuencia de aminoácidos de un polipéptido NSP 4 del virus PRRS o un fragmento de dicho polipéptido NSP 4 del virus PRRS, en donde dicho fragmento es superior a 20 residuos aminoácidos de longitud. Reivindicacion 54: Un método para determinar el estado inmunologico de un cerdo con respecto a un virus PRRS, en donde dicho estado inmunologico es que (1) dicho cerdo recibio una version de vacuna de dicho virus PRRS, (2) dicho cerdo fue infectado con una version de presentacion natural de dicho virus PRRS, o (3) dicho cerdo no tuvo contacto previo desde el punto de vista inmunologico con dicho virus PRRS, en donde dicho método comprende: a) contactar una primera muestra de dicho cerdo con un primer polipéptido bajo condiciones en donde dicho primer polipéptido forma un complejo de primer polipéptido: anticuerpo con un anticuerpo, si está presente, dentro de dicha primera muestra, en donde dicho primer polipéptido comprende una secuencia de aminoácidos tal que los anticuerpos preparados contra dicha version de vacuna de dicho virus PRRS se unen al primer polipéptido y los anticuerpos preparados contra dicha version de dicho virus PRRS de presentacion natural se unen a dicho primer polipéptido; b) contactar una segunda muestra de dicho cerdo con un segundo polipéptido bajo condiciones en done dicho segundo polipéptido forma un complejo de segundo polipéptido: anticuerpo con un anticuerpo, si está presente, dentro de dicha segunda muestra, en donde dicho segundo polipéptido comprende una secuencia de aminoácidos tal que los anticuerpos preparados contra dicha version de vacuna de dicho virus PRRS se unen al segundo polipéptido y los anticuerpos preparados contra dicha version de presentacion natural de dicho virus PRRS no se unen a dicho segundo polipéptido; y c) detectar la presencia o ausencia de dicho complejo de primer polipéptido anticuerpo y la presencia o ausencia de dicho complejo de segundo polipéptido:anticuerpo, en donde la presencia de dicho complejo de primer polipéptido:anticuerpo y la presencia de dicho complejo de segundo polipéptido:anticuerpo indica que dicho cerdo recibio dicha version de vacuna de dicho virus PRRS, en donde la presencia de dicho complejo de primer polipéptido:anticuerpo y la ausencia de dicho complejo de segundo polipéptido:anticuerpo indica que dicho cerdo fue infectado con dicha version de presentacion natural de dicho virus PRRS, y en donde la ausencia de dicho complejo del primer polipéptido:anticuerpo y al ausencia de dicho complejo de segundo polipéptido:anticuerpo indica que dicho cerdo no tuvo contacto previo, desde el punto de vista inmunologico, con dicho virus PRRS. Reivindicacion 70: Un método para aumentar la capacidad de un polipéptido unido a un soporte solido de reaccionar con un anticuerpo que se une a dicho polipéptido, comprendiendo dicho método contactar dicho soporte solido con dicho polipéptido y una lisozima.
ARP050102514A 2004-06-18 2005-06-17 Identificacion de organismos viralmente infectados y vacunados AR049924A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58132504P 2004-06-18 2004-06-18
US65619205P 2005-02-25 2005-02-25

Publications (1)

Publication Number Publication Date
AR049924A1 true AR049924A1 (es) 2006-09-13

Family

ID=35785708

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050102514A AR049924A1 (es) 2004-06-18 2005-06-17 Identificacion de organismos viralmente infectados y vacunados

Country Status (13)

Country Link
US (2) US7611717B2 (es)
EP (1) EP1781327A4 (es)
JP (1) JP2008503727A (es)
KR (1) KR20070028547A (es)
AR (1) AR049924A1 (es)
AU (1) AU2005265142A1 (es)
BR (1) BRPI0510928A (es)
CA (1) CA2571452A1 (es)
MX (1) MXPA06015105A (es)
RU (1) RU2007101725A (es)
SG (1) SG153829A1 (es)
TW (1) TW200604526A (es)
WO (1) WO2006009880A2 (es)

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TW200604526A (en) 2006-02-01
WO2006009880A3 (en) 2006-03-09
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KR20070028547A (ko) 2007-03-12
EP1781327A4 (en) 2009-02-25
CA2571452A1 (en) 2006-01-26
SG153829A1 (en) 2009-07-29
EP1781327A2 (en) 2007-05-09
US8399187B2 (en) 2013-03-19
WO2006009880A2 (en) 2006-01-26
US20070003570A1 (en) 2007-01-04
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