ME02271B - Novi evropski prrsv soj - Google Patents
Novi evropski prrsv sojInfo
- Publication number
- ME02271B ME02271B MEP-2015-135A MEP2015135A ME02271B ME 02271 B ME02271 B ME 02271B ME P2015135 A MEP2015135 A ME P2015135A ME 02271 B ME02271 B ME 02271B
- Authority
- ME
- Montenegro
- Prior art keywords
- prrsv
- virus
- ecacc
- vaccine
- atcc
- Prior art date
Links
- 241001135989 Porcine reproductive and respiratory syndrome virus Species 0.000 claims 23
- 229960005486 vaccine Drugs 0.000 claims 13
- 230000002238 attenuated effect Effects 0.000 claims 9
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 9
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 claims 8
- 241000700605 Viruses Species 0.000 claims 8
- 238000000034 method Methods 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 4
- 241000282887 Suidae Species 0.000 claims 3
- 238000004113 cell culture Methods 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 241000606748 Actinobacillus pleuropneumoniae Species 0.000 claims 2
- 241000588779 Bordetella bronchiseptica Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 241000606807 Glaesserella parasuis Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241000204045 Mycoplasma hyopneumoniae Species 0.000 claims 2
- 241000606856 Pasteurella multocida Species 0.000 claims 2
- 241000702619 Porcine parvovirus Species 0.000 claims 2
- 241000607142 Salmonella Species 0.000 claims 2
- 241000194021 Streptococcus suis Species 0.000 claims 2
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 claims 2
- 241000711484 Transmissible gastroenteritis virus Species 0.000 claims 2
- 230000000890 antigenic effect Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 229940051027 pasteurella multocida Drugs 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- 241000710788 Lelystad virus Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 229940124590 live attenuated vaccine Drugs 0.000 claims 1
- 229940023012 live-attenuated vaccine Drugs 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
- C12N2770/10064—Methods of inactivation or attenuation by serial passage
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10071—Demonstrated in vivo effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Claims (21)
1.Svinjski Virus Reproduktivnog i Respiratornog Sindroma (Porcine Reproductive and Respiratory Syndrome Virus) (PRRSV) evropskog tip, koji je soja deponovanog kod Evropske Kolekcije Ćelijskih Kultura (European Collection of Cell Cultures) (ECACC) pod Pristupnim Brojem ECACC 11012501.
2. Svinjski Virus Reproduktivnog i Respiratornog Sindroma (PRRSV) evropskog tipa, koji je soja deponovanog kod Evropske Kolekcije Ćelijskih Kultura (ECACC) pod Pristupnim Brojem ECACC 11012502.
3. PRRSV prema zahtjevu 2, pri čemu je navedeni virus oslabljen prenosom bar 36 puta kroz ćelijsku kulturu tako da kada se primjenjuje modifikovani virus na svinju ili drugog sisara sklonog na PRRSV, ne pokazuje kliničke znake PRRSV oboljenja, ali je sposoban da izazove imuni odgovor koji imunizuje sisara protiv patogenih oblika PRRSV.
4. Postupak za dobijanje živog oslabljenog PRRSV prema zahtjevu 2, obuhvata prilagođavanje MA 104-odraslog PRRSV evropskog tipa prema zahjtevu 1 na ne-MA 104 ćelije sisara.
5. Vakcina za zaštitu svinja protiv PRRSV infekcije, sadrži živi oslabljeni PRRSV prema zahtjevu 2 i farmaceutski prihvatljivi nosač.
6. Vakcina prema zahtjevu 5, koja dalje sadrži jedan ili više ne-PRRSV oslabljene ili neaktivne patogene ili njihov antigenski materijal.
7. Vakcina prema zahtjevu 6, pri čemu navedeni ne-PRRSV patogeni su odabrani između Pseudorabies virusa, Porcine influenza virusa, Porcine parvovirusa, Transmissible gastroenteritis virusa, Escherichia coli, Erysipelo rhusiopathiae, Bordetella bronchiseptica, Salmonella cholerasuis, Haemophilus parasuis, Pasteurella multocida, Streptococcus suis, Mycoplasma hyopneumoniae i Actinobacillus pleuropneumoniae.
8. Vakcina prema zahtjevu 5 koja dalje sadrži jedan ili više dodatnih evropskih PRRSV sojeva odabranih iz grupe koja se sastoji od PRRSV soja deponovanog pod Pristupnim Brojevima Lelystad virusnog soja (Lelystad Agent (CDI-NL-2.91), ili drugih sojeva kao što su oni deponovani pod Pristupnim Brojevima ECACC 04102703, ECACC 04102702, ECACC 04102704, CNCM Pristupni Br. 1-1140, CNCM Pristupni Br. 1-1387, Pristupni Br. 1-1388, ATCC VR 2332, VR 2385, VR 2386, VR 2429, VR 2474, i VR 2402; CNCM I-1102, CNCM 1-1140, CNCM 1-1387, CNCM 1-1388, ili ECACC V93070108 ili U.S. soj kao što je Severno Američki PRRS virus, pT7P129A; ATCC depozit VR-2332, ATCC depozit VR-2368; ATCC VR-2495; ATCC VR 2385, ATCC VR 2386, ATCC VR 2429, ATCC VR 2474, i ATCC VR 2402.
9. Vakcina prema zahtjevu 5, koja sadrži nosač koji je pogodan za interdermalnu ili intramuskularnu primjenu.
10. Vakcina prema zahtjevu 5, koja je u obliku koji je osušen zamrzavanjem.
11. Vakcina prema zahtjevu 5, pri čemu navedena vakcina sadrži bar 107 virusnih čestica.
12. Postupak za dobijanje živih oslabljenih vakcina za borbu protiv PRRS, sadrži mješanje živog oslabljenog PRRSV prema zahtjevu 2 sa farmaceutski prihvatljivim nosačem.
13. Postupak prema zahtjevu 12, gde živi oslabljeni PRRSV dalje obuhvata jedan ili više dodatnih evropskih PRRSV sojeva odabranih između grupe koja se sastoji od PRRSV soja deponovanog pod Pristupnim Brojevima ECACC 04102703, ECACC 04102702, ECACC 04102704, CNCM Pristupni Br. 1-1140, CNCM Pristupni Br. 1-1387, i CNCM Pristupni Br. 1-1388.
14. Postupak prema zahtjevu 12, gdje živi oslabljeni PRRSV dalje obuhvata adjuvans.
15. Vakcina prema bilo kom od zahtjeva 5 do 11, za korišćenje u postupku imunizacije svinja protiv svinjskog reproduktivnog i respiratornog sindroma (PRRS).
16. Vakcina za korišćenje prema zahtjevu 15, pri čemu navedena svinja ne pokazuje plućne lezije posle vakcinacije.
17. PRRS virus koji ima nukleotidnu sekvencu koja je bar 95% homologna sa sekvencom navedenoj ili u SEQ ID NO: 1 ili u SEQ ID NO: 10.
18. PRRS virus prema zahtjevu 17, koji ima nukleotidnu sekvencu koja je navedena ili u SEQ ID NO:1 ili u SEQ ID NO: 10.
19. Vakcina za zaštitu svinja protiv PRRSV infekcije, sadrži PRRS virus prema zahtjevu 17 ili 18 i farmaceutski prihvatljivi nosač, pri čemu navedeni PRRS virus ima nukleotidnu sekvencu koja je navedena u SEQ ID NO: 1, ili je oslabljeni PRRS virus koji ima nukleotidnu sekvencu koja je bar 95% homologna sa sekvencionim setom navedenim u SEQ ID NO:1.
20. Vakcina prema zahtjevu 19, koja dalje obuhvata jedan ili više ne-PRRSV oslabljenih ili neaktivnih patogena ili njihov antigenski materijal.
21. Vakcina prema zahtjevu 20, gdje navedeni ne-PRRSV patogeni su odabrani između Pseudorabies virusa, Porcine influenza virusa, Porcine parvovirusa, Transmissible gastroenteritis virusa, Escherichia coli, Erysipelo rhusiopathiae, Bordetella bronchiseptica, Salmonella cholerasuis, Haemophilus parasuis, Pasteurella multocida, Streptococcus suis, Mycoplasma hyopneumoniae i Actinobacillus pleuropneumoniae
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161444074P | 2011-02-17 | 2011-02-17 | |
| EP12704409.7A EP2675475B1 (en) | 2011-02-17 | 2012-02-14 | Novel european prrsv strain |
| PCT/EP2012/052475 WO2012110489A2 (en) | 2011-02-17 | 2012-02-14 | Novel european prrsv strain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02271B true ME02271B (me) | 2016-02-20 |
Family
ID=45614840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2015-135A ME02271B (me) | 2011-02-17 | 2012-02-14 | Novi evropski prrsv soj |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US8765142B2 (me) |
| EP (2) | EP2675475B1 (me) |
| JP (1) | JP5788027B2 (me) |
| KR (2) | KR102073075B1 (me) |
| CN (2) | CN103370078B (me) |
| AR (2) | AR085272A1 (me) |
| AU (2) | AU2012217169B2 (me) |
| BR (2) | BR112013021076B1 (me) |
| CA (1) | CA2826341C (me) |
| CL (1) | CL2013002379A1 (me) |
| CO (1) | CO6791570A2 (me) |
| CY (1) | CY1116835T1 (me) |
| DK (2) | DK2959916T3 (me) |
| EA (2) | EA035624B1 (me) |
| ES (2) | ES2692809T3 (me) |
| HR (1) | HRP20151031T1 (me) |
| HU (1) | HUE027731T2 (me) |
| ME (1) | ME02271B (me) |
| MX (2) | MX355058B (me) |
| MY (2) | MY186535A (me) |
| PH (2) | PH12013501709B1 (me) |
| PL (2) | PL2959916T3 (me) |
| PT (2) | PT2959916T (me) |
| RS (1) | RS54231B1 (me) |
| SG (1) | SG192820A1 (me) |
| SI (1) | SI2675475T1 (me) |
| SM (1) | SMT201500236B (me) |
| TW (2) | TWI673362B (me) |
| UA (2) | UA117272C2 (me) |
| WO (1) | WO2012110489A2 (me) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2675475B1 (en) | 2011-02-17 | 2015-07-01 | Boehringer Ingelheim Vetmedica GmbH | Novel european prrsv strain |
| SG192821A1 (en) | 2011-02-17 | 2013-09-30 | Boehringer Ingelheim Vetmed | Commercial scale process for production of prrsv |
| US8906385B2 (en) | 2011-12-01 | 2014-12-09 | University Of Maryland, College Park | Interferon-inducing porcine reproductive and respiratory syndrome virus isolate |
| CN104302316A (zh) * | 2012-05-17 | 2015-01-21 | 佐蒂斯有限责任公司 | 在断奶之前对抗猪繁殖与呼吸综合征(prrs)病毒的有效疫苗接种 |
| US9314519B2 (en) | 2012-08-21 | 2016-04-19 | Intervet Inc. | Liquid stable virus vaccines |
| US9457073B2 (en) * | 2012-09-26 | 2016-10-04 | University Of Manitoba | Live attenuated replication-competent arteriviruses having decreased dub/deisgylating activity |
| MX366051B (es) | 2012-12-07 | 2019-06-26 | Univ Illinois | Composiciones del virus del síndrome reproductor y respiratorio de porcino y sus usos. |
| US9480739B2 (en) | 2013-03-15 | 2016-11-01 | Intervet Inc. | Bovine virus vaccines that are liquid stable |
| US9393298B2 (en) | 2013-03-15 | 2016-07-19 | Intervet Inc. | Liquid stable bovine virus vaccines |
| AR097762A1 (es) | 2013-09-27 | 2016-04-13 | Intervet Int Bv | Formulaciones secas de vacunas que son estables a temperatura ambiente |
| DK3591042T5 (da) * | 2013-12-20 | 2024-09-02 | Boehringer Ingelheim Vetmedica Gmbh | PRRS-virusvariant, cDNA-klon af europæisk PRRS-virus samt anvendelser deraf |
| US10280199B2 (en) | 2014-02-07 | 2019-05-07 | Phibro Animal Health Corporation | Coronavirus proteins and antigens |
| AR099470A1 (es) | 2014-02-17 | 2016-07-27 | Intervet Int Bv | Vacunas de virus de aves de corral líquidas |
| TWI670085B (zh) * | 2014-02-19 | 2019-09-01 | 荷蘭商英特威國際公司 | 液體穩定之豬病毒疫苗 |
| WO2016066172A1 (en) | 2014-10-27 | 2016-05-06 | Pharmacosmos Holding A/S | Treatment or prevention of anaemia in pregnant non-human mammals |
| CN106924726B (zh) * | 2015-12-29 | 2021-02-09 | 普莱柯生物工程股份有限公司 | 一种用于预防猪繁殖与呼吸综合征的疫苗组合物及其制备方法和应用 |
| EP3454893A4 (en) * | 2016-05-11 | 2020-01-01 | Phibro Animal Health Corporation | A composition comprising antigens and a mucosal adjuvant and a method for using |
| US10279031B2 (en) | 2016-05-11 | 2019-05-07 | Phibro Animal Health Corporation | Composition comprising antigens and a mucosal adjuvant and a method for using |
| PL3534939T3 (pl) | 2016-11-03 | 2023-06-12 | Boehringer Ingelheim Vetmedica Gmbh | Szczepionka przeciw parwowirusowi świń i wirusowi zespołu rozrodczo-oddechowego świń oraz sposoby ich wytwarzania |
| BR112019012158A2 (pt) | 2016-12-14 | 2019-11-12 | Zoetis Services Llc | vacinação eficaz contra cepas europeias de vírus da síndrome reprodutiva e respiratória suína (prrs) antes do desmame |
| US11013796B2 (en) | 2018-08-30 | 2021-05-25 | Iowa State University Research Foundation, Inc. | Porcine parainfluenza virus type 1 isolates and immunogenic compositions therefrom |
| PH12021552477A1 (en) | 2019-04-04 | 2022-07-18 | Boehringer Ingelheim Animal Health Usa Inc | Porcine circovirus type 3 (pcv3) vaccines, and production and uses thereof |
| CN110735005B (zh) * | 2019-11-26 | 2023-01-10 | 广西大学 | Siv和prrsv多重rt-pcr快速检测试剂盒及引物 |
| CN111676247A (zh) * | 2020-06-30 | 2020-09-18 | 扬州大学 | 一株猪繁殖与呼吸综合征病毒1型分离株感染性克隆构建、拯救与应用 |
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