ES2152304T3 - Procedimiento para el crecimiento del virus del sindrome reproductivo y respiratorio porcino y su uso en vacunas. - Google Patents
Procedimiento para el crecimiento del virus del sindrome reproductivo y respiratorio porcino y su uso en vacunas.Info
- Publication number
- ES2152304T3 ES2152304T3 ES94907895T ES94907895T ES2152304T3 ES 2152304 T3 ES2152304 T3 ES 2152304T3 ES 94907895 T ES94907895 T ES 94907895T ES 94907895 T ES94907895 T ES 94907895T ES 2152304 T3 ES2152304 T3 ES 2152304T3
- Authority
- ES
- Spain
- Prior art keywords
- virus
- prrsv
- vaccines
- growth
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/815—Viral vaccine for porcine species, e.g. swine
Abstract
UN PROCESO PARA DESARROLLAR UN PRRSV EN UN CULTIVO DE TEJIDO QUE SEA SUSCEPTIBLE DE INFECCION PARA REPRODUCIR EXACTAMENTE EL VIRUS EN UNA CANTIDAD SUFICIENTE PARA PROTEGER LOS ANIMALES CONTRA PRRS O SER USADA PARA DIAGNOSTICAR PRRS O IDENTIFICAR LA ESTRUCTURA MOLECULAR DE PRRSV PARA DESARROLLAR PRODUCTOS RECOMBINANTES, QUE COMPRENDEN LA INOCULACION DEL VIRUS EN EL CULTIVO DE TEJIDO Y COSECHAR EL VIRUS REPRODUCIDO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1491593A | 1993-02-08 | 1993-02-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2152304T3 true ES2152304T3 (es) | 2001-02-01 |
Family
ID=21768529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94907895T Expired - Lifetime ES2152304T3 (es) | 1993-02-08 | 1994-01-26 | Procedimiento para el crecimiento del virus del sindrome reproductivo y respiratorio porcino y su uso en vacunas. |
Country Status (21)
Country | Link |
---|---|
US (2) | US5510258A (es) |
EP (1) | EP0683816B1 (es) |
JP (1) | JP3710095B2 (es) |
KR (1) | KR100374295B1 (es) |
CN (1) | CN1080300C (es) |
AT (1) | ATE197314T1 (es) |
AU (1) | AU681874B2 (es) |
BG (1) | BG63170B1 (es) |
CZ (1) | CZ289743B6 (es) |
DE (1) | DE69426228T2 (es) |
DK (1) | DK0683816T3 (es) |
ES (1) | ES2152304T3 (es) |
FI (1) | FI117513B (es) |
GR (1) | GR3035257T3 (es) |
HU (1) | HU218430B (es) |
NO (1) | NO317662B1 (es) |
NZ (1) | NZ261992A (es) |
PL (1) | PL178609B1 (es) |
PT (1) | PT683816E (es) |
SK (1) | SK98695A3 (es) |
WO (1) | WO1994018311A1 (es) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5620691A (en) | 1991-06-06 | 1997-04-15 | Stichting Centraal Diergeneeskundig Instituut | Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits |
US6080570A (en) * | 1991-08-26 | 2000-06-27 | Boehringer Ingelheim Vetmedica, Inc. | Method of producing a vaccine for Swine Infertility and Respiratory Syndrome |
US5846805A (en) | 1991-08-26 | 1998-12-08 | Boehringer Ingelheim Animal Health, Inc. | Culture of swine infertility and respiratory syndrome virus in simian cells |
US6042830A (en) * | 1992-08-05 | 2000-03-28 | Boehringer Ingelheim Vetmedica, Inc. | Viral agent associated with mystery swine disease |
US6982160B2 (en) * | 1991-08-26 | 2006-01-03 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions that include SIRS virus |
US6592873B1 (en) | 1992-10-30 | 2003-07-15 | Iowa State University Research Foundation, Inc. | Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids |
US5695766A (en) | 1992-10-30 | 1997-12-09 | Iowa State University Research Foundation | Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome |
US6773908B1 (en) | 1992-10-30 | 2004-08-10 | Iowa State University Research Foundation, Inc. | Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV) |
US6380376B1 (en) | 1992-10-30 | 2002-04-30 | Iowa State University Research Foundation | Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV) |
ES2074950B1 (es) * | 1993-09-17 | 1996-03-16 | Iberica Cyanamid | Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda. |
US5690940A (en) * | 1995-06-21 | 1997-11-25 | Regents Of The University Of Minnesota | Low pathogencity PRRS live virus vaccines and methods of preparation thereof |
ES2102971B1 (es) * | 1996-01-25 | 1998-03-01 | Hipra Lab Sa | Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion. |
US5866401A (en) * | 1996-03-01 | 1999-02-02 | Schering Corporation | Porcine reproductive and respiratory syndrome vaccine |
US6015663A (en) * | 1996-03-01 | 2000-01-18 | The United States Of America As Represented By The Secretary Of Agriculture | Restriction enzyme screen for differentiating porcine reproductive and respiratory syndrome virus strains |
PL328627A1 (en) * | 1996-03-01 | 1999-02-15 | Schering Corp | Vaccine against the syndrome of reproductive and respiratory disorders among swine |
US5976537A (en) * | 1996-07-02 | 1999-11-02 | The United States Of America As Represented By The Secretary Of Agriculture | Porcine reproductive and respiratory syndrome vaccine |
ATE199022T1 (de) * | 1996-10-09 | 2001-02-15 | Akzo Nobel Nv | Europäische vakzinstämme des fortplanzungs- atmungs-syndromsvirus des sweins (prrsv) |
US20040224327A1 (en) * | 1996-10-30 | 2004-11-11 | Meulenberg Johanna Jacoba Maria | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
EP0839912A1 (en) * | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
WO1998035023A1 (en) * | 1997-02-07 | 1998-08-13 | Origen, Inc. | Method for growing porcine reproductive and respiratory syndrome virus for use as vaccines and diagnostic assays |
DE69837992T2 (de) | 1997-05-06 | 2008-03-20 | Boehringer Ingelheim Vetmedica Gmbh | Prrsv-antigene, die auf peptidsequenzen des prrs-virus basieren, für die verwendung als impfstoff und für diagnostische tests |
WO1999002184A1 (en) * | 1997-07-10 | 1999-01-21 | Regents Of The University Of Minnesota | Causative agent of sow abortion and mortality syndrome (sams), vaccine compositions, antibodies and method |
UA78180C2 (uk) | 1997-10-03 | 2007-03-15 | Меріаль | Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти |
FR2772047B1 (fr) * | 1997-12-05 | 2004-04-09 | Ct Nat D Etudes Veterinaires E | Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection |
NZ501264A (en) | 1998-12-22 | 2001-09-28 | Pfizer Prod Inc | Polynucleotide DNA sequence encoding an infectious RNA molecule encoding a North American PRRS |
JP3961222B2 (ja) | 1999-03-08 | 2007-08-22 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | Prrsvワクチン |
DK1183332T3 (da) * | 1999-04-22 | 2010-09-06 | Us Agriculture | Porcint Reproduktions- og Respirations Syndrom-vaccine baseret på isolere JA-142 |
US6497883B1 (en) * | 1999-06-10 | 2002-12-24 | Merial | Porcine circovirus recombinant poxvirus vaccine |
ES2170622B1 (es) * | 1999-12-03 | 2004-05-16 | Consejo Superior De Investigaciones Cientificas | Clones y vectores infectivos derivados de coronavirus y sus aplicaciones. |
DK1240310T3 (da) * | 1999-12-20 | 2008-05-26 | Agricultural Research Council | Fremgangsmåde til inaktivering af mikroorganismer |
ATE333500T1 (de) * | 2000-02-08 | 2006-08-15 | Univ Minnesota | Virus des porzinen reproduktiven und respiratorischen syndroms und dessen verwendung |
US6740490B2 (en) * | 2001-01-29 | 2004-05-25 | Kansas State University Research Foundation | Identification and applications of porcine reproductive and respiratory syndrome virus host susceptibility factor(s) for improved swine breeding |
US6841364B2 (en) * | 2002-01-22 | 2005-01-11 | Protatek International, Inc. | Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof |
US7906311B2 (en) | 2002-03-20 | 2011-03-15 | Merial Limited | Cotton rat lung cells for virus culture |
SG153829A1 (en) | 2004-06-18 | 2009-07-29 | Univ Minnesota | Identifying virally infected and vaccinated organisms |
US7632636B2 (en) | 2004-09-21 | 2009-12-15 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome isolates and methods of use |
PT2281829E (pt) | 2004-12-30 | 2015-02-18 | Boehringer Ingelheim Vetmed | Composições imunogénicas de pcv2 para utilização num método de prevenção de infecção de pcv2 |
US7691368B2 (en) | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
PT2369001T (pt) | 2005-06-24 | 2016-10-25 | Univ Minnesota | Vírus srrp, clones infecciosos, os seus mutantes e processos de utilização |
RU2488407C2 (ru) | 2005-12-29 | 2013-07-27 | Берингер Ингельхайм Ветмедика, Инк. | Поливалентные иммуногенные композиции pcv2 и способы получения таких композиций |
CN100523177C (zh) * | 2007-01-09 | 2009-08-05 | 中国农业科学院哈尔滨兽医研究所 | 猪繁殖与呼吸综合症病毒弱毒疫苗株及其应用 |
DK2106440T3 (en) * | 2007-01-12 | 2015-12-14 | Univ Illinois | NON-SIMIANCES FOR CULTIVATING PORCINT REPRODUCTION AND RESPIRATION SYNDROME (PRRS) VIRUS |
US7666585B2 (en) * | 2007-06-15 | 2010-02-23 | Protatek International, Inc. | Construction of chimera PRRSV, compositions and vaccine preparations |
ES2389748T3 (es) * | 2007-06-25 | 2012-10-31 | South Dakota State University | Virus del síndrome reproductivo y respiratorio porcino de tipo 1 norteamericano recombinante y métodos de uso |
FI122778B (fi) | 2008-03-31 | 2012-06-29 | Metso Power Oy | Pyrolyysimenetelmä kattilan yhteydessä ja pyrolyysilaitteisto |
CN101363865B (zh) * | 2008-05-26 | 2013-03-06 | 北京庄笛浩禾生物医学科技有限公司 | 一种猪蓝耳病毒胶体金检测试纸条、其制备方法及其应用 |
KR101653177B1 (ko) * | 2008-08-25 | 2016-09-01 | 베링거잉겔하임베트메디카인코퍼레이티드 | 고병원성 돼지 생식기 및 호흡기 증후군(hp prrs)에 대한 백신 |
AR078253A1 (es) | 2009-09-02 | 2011-10-26 | Boehringer Ingelheim Vetmed | Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad |
KR101746880B1 (ko) | 2009-09-10 | 2017-06-14 | 메리얼 인코포레이티드 | 사포닌-함유 면역보강제를 포함하는 신규 백신 제형 |
BR122021013826B1 (pt) | 2011-02-17 | 2022-11-22 | Boehringer Ingelheim Vetmedica Gmbh | Composição de proteína, ácido nucleico isolado e vetor de expressão recombinante |
MX346636B (es) | 2011-02-17 | 2017-03-27 | Boehringer Ingelheim Vetmedica Gmbh | Procedimiento para la produccion a escala comercial de prrsv. |
WO2013017570A1 (en) | 2011-07-29 | 2013-02-07 | Boehringer Ingelheim Vetmedica Gmbh | Novel prrs virus inducing type i interferon in susceptible cells |
US9187731B2 (en) | 2011-07-29 | 2015-11-17 | Boehringer Ingelheim Vetmedica Gmbh | PRRS virus inducing type I interferon in susceptible cells |
DK2741740T3 (en) | 2011-08-12 | 2017-06-06 | Merial Inc | VACUUM-SUPPORTED CONSERVATION OF BIOLOGICAL PRODUCTS, IN PARTICULAR OF VACCINES |
EP2929018A4 (en) | 2012-12-07 | 2016-07-13 | Univ Illinois | PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS COMPOSITION AND USES THEREOF |
US9579373B2 (en) | 2013-03-15 | 2017-02-28 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use |
KR20160046879A (ko) | 2013-09-25 | 2016-04-29 | 조에티스 서비시즈 엘엘씨 | Pcv2b 분지형 백신 조성물 및 사용 방법 |
TWI745278B (zh) | 2014-10-10 | 2021-11-11 | 以色列商艾畢克生物實驗有限公司 | 發泡性降低之疫苗組合物 |
CN104694485A (zh) * | 2015-02-13 | 2015-06-10 | 广西壮族自治区兽医研究所 | Z-ietd-fmk在提高prrsv体外培养滴度方面的应用及其方法 |
JP7018941B2 (ja) | 2016-06-17 | 2022-02-14 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 直鎖または分枝ポリアクリル酸ポリマーアジュバントを含む新規な免疫原性処方物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5213795A (en) * | 1990-10-24 | 1993-05-25 | Oxford | Encephalomyocarditis virus vaccine |
US5620691A (en) * | 1991-06-06 | 1997-04-15 | Stichting Centraal Diergeneeskundig Instituut | Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits |
DE69214657T4 (de) * | 1991-08-26 | 2003-07-17 | Boehringer Ingelheim Vetmed | Vakzine gegen und diagnosemethode für das schweine-unfruchtbarkeits- und atmungs-syndrom (suas) |
CA2076744C (en) * | 1991-08-26 | 2000-06-27 | Danny W. Chladek | Viral agent associated with mystery swine disease |
WO1993006211A1 (en) * | 1991-09-16 | 1993-04-01 | Collins James E | Vaccine for mystery swine disease and method for diagnosis thereof |
WO1993007898A1 (en) * | 1991-10-14 | 1993-04-29 | Akzo Nobel N.V. | Porcine reproductive respiratory syndrome vaccine and diagnostic |
FR2682966B1 (fr) * | 1991-10-29 | 1994-12-02 | Rhone Merieux | Preparation d'antigenes et de vaccins du virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie. |
US5695766A (en) * | 1992-10-30 | 1997-12-09 | Iowa State University Research Foundation | Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome |
-
1994
- 1994-01-26 DK DK94907895T patent/DK0683816T3/da active
- 1994-01-26 NZ NZ261992A patent/NZ261992A/en not_active IP Right Cessation
- 1994-01-26 WO PCT/US1994/000951 patent/WO1994018311A1/en active IP Right Grant
- 1994-01-26 DE DE69426228T patent/DE69426228T2/de not_active Expired - Fee Related
- 1994-01-26 SK SK986-95A patent/SK98695A3/sk unknown
- 1994-01-26 PL PL94310126A patent/PL178609B1/pl not_active IP Right Cessation
- 1994-01-26 CN CN94191129A patent/CN1080300C/zh not_active Expired - Fee Related
- 1994-01-26 PT PT94907895T patent/PT683816E/pt unknown
- 1994-01-26 ES ES94907895T patent/ES2152304T3/es not_active Expired - Lifetime
- 1994-01-26 AT AT94907895T patent/ATE197314T1/de not_active IP Right Cessation
- 1994-01-26 JP JP51810194A patent/JP3710095B2/ja not_active Expired - Fee Related
- 1994-01-26 KR KR1019950703246A patent/KR100374295B1/ko not_active IP Right Cessation
- 1994-01-26 AU AU61285/94A patent/AU681874B2/en not_active Ceased
- 1994-01-26 EP EP94907895A patent/EP0683816B1/en not_active Expired - Lifetime
- 1994-01-26 CZ CZ19952031A patent/CZ289743B6/cs not_active IP Right Cessation
- 1994-01-26 HU HU9502330A patent/HU218430B/hu not_active IP Right Cessation
- 1994-06-01 US US08/252,612 patent/US5510258A/en not_active Expired - Lifetime
- 1994-12-06 US US08/349,865 patent/US5587164A/en not_active Expired - Lifetime
-
1995
- 1995-08-04 FI FI953731A patent/FI117513B/fi active IP Right Grant
- 1995-08-07 NO NO19953091A patent/NO317662B1/no unknown
- 1995-08-08 BG BG99850A patent/BG63170B1/bg unknown
-
2001
- 2001-01-17 GR GR20010400077T patent/GR3035257T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1994018311A1 (en) | 1994-08-18 |
US5587164A (en) | 1996-12-24 |
CZ203195A3 (en) | 1995-12-13 |
BG99850A (bg) | 1996-02-28 |
PL310126A1 (en) | 1995-11-27 |
GR3035257T3 (en) | 2001-04-30 |
ATE197314T1 (de) | 2000-11-15 |
EP0683816B1 (en) | 2000-11-02 |
CN1117742A (zh) | 1996-02-28 |
PL178609B1 (pl) | 2000-05-31 |
KR100374295B1 (ko) | 2003-12-24 |
CZ289743B6 (cs) | 2002-03-13 |
NO953091D0 (no) | 1995-08-07 |
HU9502330D0 (en) | 1996-05-28 |
JPH08506486A (ja) | 1996-07-16 |
NO953091L (no) | 1995-08-07 |
NZ261992A (en) | 1996-06-25 |
AU6128594A (en) | 1994-08-29 |
FI117513B (fi) | 2006-11-15 |
FI953731A0 (fi) | 1995-08-04 |
SK98695A3 (en) | 1996-11-06 |
AU681874B2 (en) | 1997-09-11 |
US5510258A (en) | 1996-04-23 |
JP3710095B2 (ja) | 2005-10-26 |
BG63170B1 (bg) | 2001-05-31 |
PT683816E (pt) | 2001-03-30 |
EP0683816A1 (en) | 1995-11-29 |
HUT72917A (en) | 1996-06-28 |
CN1080300C (zh) | 2002-03-06 |
DE69426228D1 (de) | 2000-12-07 |
DE69426228T2 (de) | 2001-03-01 |
DK0683816T3 (da) | 2001-01-08 |
FI953731A (fi) | 1995-08-04 |
HU218430B (hu) | 2000-08-28 |
NO317662B1 (no) | 2004-11-29 |
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