PL2959916T3 - Nowy europejski szczep prrsv - Google Patents

Nowy europejski szczep prrsv

Info

Publication number
PL2959916T3
PL2959916T3 PL15174330T PL15174330T PL2959916T3 PL 2959916 T3 PL2959916 T3 PL 2959916T3 PL 15174330 T PL15174330 T PL 15174330T PL 15174330 T PL15174330 T PL 15174330T PL 2959916 T3 PL2959916 T3 PL 2959916T3
Authority
PL
Poland
Prior art keywords
prrsv strain
european prrsv
novel european
novel
strain
Prior art date
Application number
PL15174330T
Other languages
English (en)
Inventor
Stefan Pesch
Kim BURGARD
Volker Ohlinger
Francois-Xavier Orveillon
Jeremy Kroll
Sarah LAYTON
Michael Dennis PIONTKOWSKI
Michael B. Roof
Philip Utley
Eric Martin Vaughn
Original Assignee
Boehringer Ingelheim Vetmedica Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmedica Gmbh filed Critical Boehringer Ingelheim Vetmedica Gmbh
Publication of PL2959916T3 publication Critical patent/PL2959916T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10061—Methods of inactivation or attenuation
    • C12N2770/10064—Methods of inactivation or attenuation by serial passage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10071—Demonstrated in vivo effect
PL15174330T 2011-02-17 2012-02-14 Nowy europejski szczep prrsv PL2959916T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161444074P 2011-02-17 2011-02-17
EP12704409.7A EP2675475B1 (en) 2011-02-17 2012-02-14 Novel european prrsv strain
PCT/EP2012/052475 WO2012110489A2 (en) 2011-02-17 2012-02-14 Novel european prrsv strain
EP15174330.9A EP2959916B1 (en) 2011-02-17 2012-02-14 Novel european prrsv strain

Publications (1)

Publication Number Publication Date
PL2959916T3 true PL2959916T3 (pl) 2019-05-31

Family

ID=45614840

Family Applications (2)

Application Number Title Priority Date Filing Date
PL12704409T PL2675475T3 (pl) 2011-02-17 2012-02-14 Nowy europejski szczep prrs
PL15174330T PL2959916T3 (pl) 2011-02-17 2012-02-14 Nowy europejski szczep prrsv

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL12704409T PL2675475T3 (pl) 2011-02-17 2012-02-14 Nowy europejski szczep prrs

Country Status (30)

Country Link
US (4) US8765142B2 (pl)
EP (2) EP2959916B1 (pl)
JP (1) JP5788027B2 (pl)
KR (2) KR102183276B1 (pl)
CN (2) CN106110318A (pl)
AR (2) AR085272A1 (pl)
AU (2) AU2012217169B2 (pl)
BR (2) BR112013021076B1 (pl)
CA (1) CA2826341C (pl)
CL (1) CL2013002379A1 (pl)
CO (1) CO6791570A2 (pl)
CY (1) CY1116835T1 (pl)
DK (2) DK2675475T3 (pl)
EA (2) EA035624B1 (pl)
ES (2) ES2692809T3 (pl)
HR (1) HRP20151031T1 (pl)
HU (1) HUE027731T2 (pl)
ME (1) ME02271B (pl)
MX (2) MX355058B (pl)
MY (2) MY186535A (pl)
PH (1) PH12017500962A1 (pl)
PL (2) PL2675475T3 (pl)
PT (2) PT2959916T (pl)
RS (1) RS54231B1 (pl)
SG (1) SG192820A1 (pl)
SI (1) SI2675475T1 (pl)
SM (1) SMT201500236B (pl)
TW (2) TWI673362B (pl)
UA (2) UA117272C2 (pl)
WO (1) WO2012110489A2 (pl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8765142B2 (en) 2011-02-17 2014-07-01 Boehringer Ingelheim Vetmedica Gmbh European PRRSV strain
BR112013020966B1 (pt) 2011-02-17 2020-05-26 Boehringer Ingelheim Vetmedica Gmbh Processo em escala comercial para produção do prrsv
US8906385B2 (en) 2011-12-01 2014-12-09 University Of Maryland, College Park Interferon-inducing porcine reproductive and respiratory syndrome virus isolate
JP6386999B2 (ja) 2012-05-17 2018-09-05 ゾエティス・エルエルシー ブタ生殖および呼吸症候群（ｐｒｒｓ）ウイルスに対する離乳前の効果的なワクチン接種
US9314519B2 (en) 2012-08-21 2016-04-19 Intervet Inc. Liquid stable virus vaccines
US9457073B2 (en) * 2012-09-26 2016-10-04 University Of Manitoba Live attenuated replication-competent arteriviruses having decreased dub/deisgylating activity
EP2929018A4 (en) 2012-12-07 2016-07-13 Univ Illinois PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS COMPOSITION AND USES THEREOF
US9393298B2 (en) 2013-03-15 2016-07-19 Intervet Inc. Liquid stable bovine virus vaccines
US9480739B2 (en) 2013-03-15 2016-11-01 Intervet Inc. Bovine virus vaccines that are liquid stable
AR097762A1 (es) 2013-09-27 2016-04-13 Intervet Int Bv Formulaciones secas de vacunas que son estables a temperatura ambiente
MX2016007737A (es) * 2013-12-20 2016-09-07 Boehringer Ingelheim Vetmedica Gmbh Variante del virus prrs, clon de adnc del virus europeo y sus usos.
US10280199B2 (en) 2014-02-07 2019-05-07 Phibro Animal Health Corporation Coronavirus proteins and antigens
AR099470A1 (es) 2014-02-17 2016-07-27 Intervet Int Bv Vacunas de virus de aves de corral líquidas
TWI670085B (zh) * 2014-02-19 2019-09-01 荷蘭商英特威國際公司 液體穩定之豬病毒疫苗
WO2016066172A1 (en) * 2014-10-27 2016-05-06 Pharmacosmos Holding A/S Treatment or prevention of anaemia in pregnant non-human mammals
CN106924726B (zh) * 2015-12-29 2021-02-09 普莱柯生物工程股份有限公司 一种用于预防猪繁殖与呼吸综合征的疫苗组合物及其制备方法和应用
EP3454893A4 (en) * 2016-05-11 2020-01-01 Phibro Animal Health Corporation COMPOSITION WITH ANTIGENS AND A MUCUTINE ADJUVAN AND METHOD FOR USE
US10279031B2 (en) 2016-05-11 2019-05-07 Phibro Animal Health Corporation Composition comprising antigens and a mucosal adjuvant and a method for using
RS64144B1 (sr) 2016-11-03 2023-05-31 Boehringer Ingelheim Vetmedica Gmbh Vakcina protiv svinjskog parvovirusa i virusa reproduktivnog i respiratornog sindroma svinja i postupci njegove proizvodnje
BR112019012158A2 (pt) 2016-12-14 2019-11-12 Zoetis Services Llc vacinação eficaz contra cepas europeias de vírus da síndrome reprodutiva e respiratória suína (prrs) antes do desmame
US11013796B2 (en) 2018-08-30 2021-05-25 Iowa State University Research Foundation, Inc. Porcine parainfluenza virus type 1 isolates and immunogenic compositions therefrom
CN114222579A (zh) 2019-04-04 2022-03-22 勃林格殷格翰动物保健美国有限公司 猪圆环病毒3型（pcv3）疫苗及其生产和用途
CN110735005B (zh) * 2019-11-26 2023-01-10 广西大学 Siv和prrsv多重rt-pcr快速检测试剂盒及引物
CN111676247A (zh) * 2020-06-30 2020-09-18 扬州大学 一株猪繁殖与呼吸综合征病毒1型分离株感染性克隆构建、拯救与应用
JP2023535066A (ja) 2020-07-24 2023-08-15 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 組合せブタワクチン
CN113862230B (zh) * 2021-09-30 2023-08-08 中牧实业股份有限公司 一种猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用

Family Cites Families (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE148705C (pl)
US3137631A (en) 1959-12-01 1964-06-16 Faberge Inc Encapsulation in natural products
US3080291A (en) 1960-06-10 1963-03-05 Jensen Salsberg Lab Inc Serial passage of distemper virus in tissue cultures of chick embryo and canine tissue and vaccine therefrom
US3959457A (en) 1970-06-05 1976-05-25 Temple University Microparticulate material and method of making such material
US4015100A (en) 1974-01-07 1977-03-29 Avco Everett Research Laboratory, Inc. Surface modification
US4122167A (en) 1977-02-09 1978-10-24 Merck & Co., Inc. Respiratory synctial vaccine
US4205060A (en) 1978-12-20 1980-05-27 Pennwalt Corporation Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use
US4224412A (en) 1979-05-01 1980-09-23 Dorofeev Viktor M Living virus culture vaccine against canine distemper and method of preparing same
US4554159A (en) 1981-11-12 1985-11-19 Institute Merieux Vaccine and method of immunizing against herpes simplex virus (types 1 and 2)
US4452747A (en) 1982-03-22 1984-06-05 Klaus Gersonde Method of and arrangement for producing lipid vesicles
GB8319302D0 (en) 1983-07-16 1983-08-17 Tpt Ltd Container
US4468346A (en) 1983-10-27 1984-08-28 The United States Of America As Represented By The Secretary Of Agriculture Monoclonal antibodies to porcine immunoglobulins
DE3405100A1 (de) 1984-02-14 1985-08-14 Drägerwerk AG, 2400 Lübeck Pt-katalysator auf einem traeger als luftreinigungsmittel
US4744933A (en) 1984-02-15 1988-05-17 Massachusetts Institute Of Technology Process for encapsulation and encapsulated active material system
US5008050A (en) 1984-06-20 1991-04-16 The Liposome Company, Inc. Extrusion technique for producing unilamellar vesicles
US4921706A (en) 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US4606940A (en) 1984-12-21 1986-08-19 The Ohio State University Research Foundation Small particle formation and encapsulation
EP0208672B1 (en) 1985-07-08 1993-02-17 REGION WALLONNE représentée par le Ministre des Technologies pour la Région wallonne dans ses attributions Vaccines and diagnostics derived from bovine diarrhea virus
US5206163A (en) 1985-07-08 1993-04-27 Chiron Corporation DNA encoding bovine diarrhea virus protein
US4753884A (en) 1986-01-28 1988-06-28 Novagene, Inc. Pseudorabies virus mutants, vaccines containing same, methods for the production of same and methods for the use of same
JPS62198626A (ja) 1986-02-26 1987-09-02 Biseibutsu Kagaku Kenkyusho:Kk 血球凝集性脳脊髄炎ウイルス感染症予防ワクチン
FR2602791B1 (fr) 1986-08-18 1988-11-10 Ministere Agri Direction Quali Procede de culture du virus de la rhinotracheite infectieuse de la dinde, et vaccin prepare a partir du virus ainsi obtenu
NZ222465A (en) 1986-11-07 1992-11-25 Pasteur Institut Nanb (non a, non b hepatitis viral) antigen
US5009956A (en) 1987-02-24 1991-04-23 Univ Minnesota Phospholipase A2-resistant liposomes
DE3833925A1 (de) 1988-03-11 1989-09-21 Inst Angewandte Biotechnologie Verfahren und herstellung von virus und viralem antigen und vorrichtung hierzu
US5213759A (en) 1988-05-05 1993-05-25 Elopak Systems A.G. Sterilization
US4927637A (en) 1989-01-17 1990-05-22 Liposome Technology, Inc. Liposome extrusion method
US4944948A (en) 1989-02-24 1990-07-31 Liposome Technology, Inc. EGF/Liposome gel composition and method
US5132117A (en) 1990-01-11 1992-07-21 Temple University Aqueous core microcapsules and method for their preparation
AU7007491A (en) 1990-02-02 1991-08-08 Schweiz. Serum- & Impfinstitut Bern Cdna corresponding to the genome of negative-strand rna viruses, and process for the production of infectious negative-strand rna viruses
UA27788C2 (uk) 1991-06-06 2000-10-16 Стіхтінг Сентрал Діргенескюндіг Інстітют Композиція, що містить виділений фактор лелістада, вакцинна композиція для вакцинації тварин (варіанти), діагностичний набір для виявлення антитіла
MX9204885A (es) 1991-08-26 1994-05-31 Boehringer Animal Health Inc Composicion de vacuna que comprende virus del sindrome de infertilidad y respiratorio de los cerdos.
US6982160B2 (en) 1991-08-26 2006-01-03 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions that include SIRS virus
ES2065303T5 (es) 1991-08-26 2001-05-01 Univ Minnesota Procedimiento de diagnosis y vacuna especifica.
US6042830A (en) 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
US5846805A (en) 1991-08-26 1998-12-08 Boehringer Ingelheim Animal Health, Inc. Culture of swine infertility and respiratory syndrome virus in simian cells
US6080570A (en) 1991-08-26 2000-06-27 Boehringer Ingelheim Vetmedica, Inc. Method of producing a vaccine for Swine Infertility and Respiratory Syndrome
WO1993006211A1 (en) 1991-09-16 1993-04-01 Collins James E Vaccine for mystery swine disease and method for diagnosis thereof
AU2684792A (en) 1991-10-14 1993-05-21 Akzo Nobel N.V. Porcine reproductive respiratory syndrome vaccine and diagnostic
FR2686097B1 (fr) 1992-01-14 1994-12-30 Rhone Merieux Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie.
US5338543A (en) 1992-02-27 1994-08-16 Ambico, Inc. Thimerosal inactivated mycoplasma hyopneumoniae vaccine
TW289731B (pl) 1992-07-09 1996-11-01 Akzo Nv
US6251397B1 (en) 1992-10-30 2001-06-26 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same
US6380376B1 (en) 1992-10-30 2002-04-30 Iowa State University Research Foundation Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US5695766A (en) 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
US6592873B1 (en) 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
US6773908B1 (en) 1992-10-30 2004-08-10 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US5419907A (en) 1992-11-10 1995-05-30 Iowa State University Research Foundation, Inc. Pathogenic porcine respiratory coronavirus
KR100374295B1 (ko) 1993-02-08 2003-12-24 바이엘 코포레이션 돼지생식및호흡증후군바이러스의생육방법과백신에서그의용도
ES2074950B1 (es) 1993-09-17 1996-03-16 Iberica Cyanamid Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda.
EP0659885A1 (en) 1993-12-21 1995-06-28 Akzo Nobel N.V. Vaccine against viruses associated with antibody-dependent-enhancement of viral infectivity
DE4407489A1 (de) 1994-03-07 1995-09-14 Bayer Ag Vakzine zur Prävention von Respirations- und Reproduktionserkrankungen des Schweines
DE69522984T2 (de) 1994-04-11 2002-04-25 Akzo Nobel Nv Europäische Vakzinstämme des Fortplanzungs-Atmungs-Syndromsvirus des Schweins
DE69530227T2 (de) 1994-04-15 2004-04-01 Temple University Methode zum einkapseln mittels eines wässrigen lösungsmittels und mikrokapseln
DK53595A (da) 1994-05-13 1995-11-14 Iberica Cyanamid Rekombinante PRRSV-proteiner, diagnostiske kits og vaccine indeholdende sådanne rekombinante PRRSV-proteiner
MX9700817A (es) 1994-08-05 1997-05-31 Univ Minnesota Secuencia viral de nucleotidos de "vr-2332" y metodos de uso.
DE69632658T2 (de) 1995-03-14 2005-06-09 Akzo Nobel N.V. Expression in der selben Zelle von Polypeptide vom schweinen reproduktiven und respiratorischen Syndrom
US5690940A (en) 1995-06-21 1997-11-25 Regents Of The University Of Minnesota Low pathogencity PRRS live virus vaccines and methods of preparation thereof
ES2102971B1 (es) 1996-01-25 1998-03-01 Hipra Lab Sa Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion.
US5866401A (en) 1996-03-01 1999-02-02 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
CO4600644A1 (es) 1996-03-01 1998-05-08 Schering Corp Vacuna contra el sindrome reproductivo y respiratorio porcino
US6015663A (en) 1996-03-01 2000-01-18 The United States Of America As Represented By The Secretary Of Agriculture Restriction enzyme screen for differentiating porcine reproductive and respiratory syndrome virus strains
US5976537A (en) 1996-07-02 1999-11-02 The United States Of America As Represented By The Secretary Of Agriculture Porcine reproductive and respiratory syndrome vaccine
DE69704011T2 (de) 1996-10-09 2001-06-07 Akzo Nobel Nv Europäische Vakzinstämme des Fortplanzungs-Atmungs-Syndromsvirus des Sweins (PRRSV)
US20040224327A1 (en) 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
EP0839912A1 (en) 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
WO1998035023A1 (en) 1997-02-07 1998-08-13 Origen, Inc. Method for growing porcine reproductive and respiratory syndrome virus for use as vaccines and diagnostic assays
SK286063B6 (sk) 1997-05-06 2008-02-05 Boehringer Ingelheim Vetmedica Gmbh Peptid vyvolávajúci tvorbu protilátok, protilátkareaktívna s týmto peptidom a diagnostická súpravaobsahujúca peptid a protilátku
EP1003869A1 (en) 1997-06-04 2000-05-31 Calgene LLC Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants
WO1998055626A2 (en) 1997-06-05 1998-12-10 Origen, Inc. Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine
US7211379B2 (en) 1997-10-03 2007-05-01 Merial Sas Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2
US6391314B1 (en) 1997-10-03 2002-05-21 Merial Porcine circoviruses vaccines diagnostic reagents
US7691389B2 (en) 1998-12-22 2010-04-06 Pfizer Inc Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
NZ501264A (en) 1998-12-22 2001-09-28 Pfizer Prod Inc Polynucleotide DNA sequence encoding an infectious RNA molecule encoding a North American PRRS
US7132106B2 (en) 1998-12-22 2006-11-07 Pfizer Inc. Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7618797B2 (en) 1998-12-22 2009-11-17 Pfizer Inc Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
FR2789695B1 (fr) 1999-02-11 2003-03-07 Merial Sas Vecteurs et vaccins viraux a base d'adenovirus porcins recombines et replicatifs
AU3198200A (en) 1999-03-08 2000-09-28 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Prrsv vaccines
ATE474041T1 (de) 1999-04-22 2010-07-15 Us Agriculture Auf dem isolat ja-142 basierender impfstoff gegen das reproduktive-und-respiratorische syndrom beim schwein
US20040213805A1 (en) 1999-10-12 2004-10-28 Verheije Monique Helene Deletions in arterivirus replicons
US20020012670A1 (en) 2000-01-26 2002-01-31 Knut Elbers Recombinant attenuation of porcine reproductive and respiratory syndrome (PRRSV)
US7041443B2 (en) * 2000-02-08 2006-05-09 Regents Of The University Of Minnesota Porcine reproductive and respiratory syndrome virus and methods of use
EP1156111A1 (en) 2000-05-19 2001-11-21 Stichting Dienst Landbouwkundig Onderzoek Chimeric arterivirus-like particles
US7018638B2 (en) 2000-12-19 2006-03-28 Wyeth Mycoplasma hyopneumoniae bacterin vaccine
SK11282003A3 (sk) * 2001-03-09 2004-02-03 Boehringer Ingelheim Vetmedica Gmbh Oslabený európsky PRRS vírus, nukleotidová sekvencia kódujúca vírus, spôsob generovania infekčného živého oslabeného PRRS vírusu, bunková línia a farmaceutický prostriedok s jeho obsahom a jeho použitie
EP1397498A1 (en) 2001-05-21 2004-03-17 ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. Delections in arterivirus replicons
US7279166B2 (en) 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US6841364B2 (en) 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
EP1350840B1 (en) 2002-04-05 2012-05-09 Boehringer Ingelheim Vetmedica GmbH Adaptation sites of PRRSV
US7335361B2 (en) 2003-06-09 2008-02-26 Animal Technology Institute Taiwan Fusion antigen used as vaccine
US7722878B2 (en) 2004-06-17 2010-05-25 Boehringer Ingelheim Vetmedica, Inc. PRRSV subunit vaccines
KR20070028547A (ko) 2004-06-18 2007-03-12 리전츠 오브 더 유니버스티 오브 미네소타 바이러스에 감염되고 백신접종된 생물의 동정
CN101039693A (zh) * 2004-06-18 2007-09-19 明尼苏达大学董事会 鉴定病毒感染和疫苗接种的生物
US20060063151A1 (en) 2004-09-21 2006-03-23 Michael Roof Porcine reproductive and respiratory syndrome isolates and methods of use
US7632636B2 (en) 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
KR20070064666A (ko) * 2004-11-11 2007-06-21 화이자 프로덕츠 인코포레이티드 돼지의 생식 및 호흡 증후군 바이러스 돌연변이
PL1833508T3 (pl) * 2004-11-19 2011-02-28 Intervet Int Bv Szczepy świńskiego wirusa zespołu rozrodczo-oddechowego i ich kompozycje
KR20070096019A (ko) 2005-01-13 2007-10-01 베링거잉겔하임베트메디카게엠베하 향상된 ｐｒｒｓ 백신
CA2894069C (en) 2005-06-24 2019-02-26 Regents Of The University Of Minnesota Prrs viruses, infectious clones, mutants thereof, and methods of use
CN101495138B (zh) 2005-11-29 2014-01-08 衣阿华州立大学研究基金公司 猪繁殖与呼吸综合征病毒（prrsv）的保护性抗原决定子的鉴定及其用途
US8563313B2 (en) 2007-02-13 2013-10-22 Washington State University Research Foundation Macrophage cell-lines for propagation of porcine reproductive and respiratory syndrome virus
WO2008121958A1 (en) 2007-04-02 2008-10-09 Boehringer Ingelheim Vetmedica, Inc. Use of prrsv vaccines to reduce pcv2 viremia
US20100003278A1 (en) 2008-07-03 2010-01-07 Boehringer Ingelheim Vetmedica, Inc. Immunological Compositions Effective for Lessening the Severity or Incidence of PRRSV Signs and Methods of Use Thereof
RU2561595C2 (ru) 2008-08-25 2015-08-27 Бёрингер Ингельхайм Ветмедика, Инк. Вакцина против высокопатогенного репродуктивно-респираторного синдрома свиней (hp prrs)
US20100129398A1 (en) 2008-11-26 2010-05-27 Boehringer Ingelheim Vetmedica, Inc. Materials and Methods for Control of Porcine Reproductive and Respiratory Syndrome
WO2011128415A1 (en) 2010-04-16 2011-10-20 Universiteit Gent Cross-protecting vaccine for porcine reproductive and respiratory syndrome virus
CN101920010A (zh) * 2010-06-29 2010-12-22 西北农林科技大学 表达prrsv免疫原基因的重组减毒鼠伤寒沙门氏菌载体疫苗及其制备方法
US8728487B2 (en) 2011-01-20 2014-05-20 Hua Wu Attenuated live vaccine for prevention of porcine reproductive and respiratory syndrome
US8765142B2 (en) 2011-02-17 2014-07-01 Boehringer Ingelheim Vetmedica Gmbh European PRRSV strain
BR112013020966B1 (pt) * 2011-02-17 2020-05-26 Boehringer Ingelheim Vetmedica Gmbh Processo em escala comercial para produção do prrsv
WO2013017570A1 (en) 2011-07-29 2013-02-07 Boehringer Ingelheim Vetmedica Gmbh Novel prrs virus inducing type i interferon in susceptible cells
CN105073130A (zh) 2013-03-15 2015-11-18 勃林格殷格翰动物保健公司 猪生殖与呼吸综合征病毒、组合物、疫苗及使用方法
MX2016007737A (es) 2013-12-20 2016-09-07 Boehringer Ingelheim Vetmedica Gmbh Variante del virus prrs, clon de adnc del virus europeo y sus usos.

Also Published As

Publication number Publication date
TW201638333A (zh) 2016-11-01
AR085272A1 (es) 2013-09-18
DK2675475T3 (en) 2015-09-14
EA201300915A1 (ru) 2014-02-28
US9534207B2 (en) 2017-01-03
US10039821B2 (en) 2018-08-07
CN106110318A (zh) 2016-11-16
UA117272C2 (uk) 2018-07-10
SG192820A1 (en) 2013-09-30
CA2826341A1 (en) 2012-08-23
US20140255442A1 (en) 2014-09-11
ES2692809T3 (es) 2018-12-05
BR122021013826B1 (pt) 2022-11-22
EA035624B1 (ru) 2020-07-16
MX345188B (es) 2017-01-20
CL2013002379A1 (es) 2014-02-14
US20190134180A1 (en) 2019-05-09
EP2959916B1 (en) 2018-08-08
HUE027731T2 (en) 2016-10-28
KR20200015800A (ko) 2020-02-12
EP2675475B1 (en) 2015-07-01
US20170065709A1 (en) 2017-03-09
CO6791570A2 (es) 2013-11-14
US10668144B2 (en) 2020-06-02
AU2012217169A1 (en) 2013-07-18
WO2012110489A3 (en) 2012-10-11
US20120213810A1 (en) 2012-08-23
EA201692359A1 (ru) 2017-04-28
SMT201500236B (it) 2015-10-30
US8765142B2 (en) 2014-07-01
EP2675475A2 (en) 2013-12-25
CN103370078B (zh) 2016-08-10
CA2826341C (en) 2022-02-22
MY161198A (en) 2017-04-14
JP2014507151A (ja) 2014-03-27
PL2675475T3 (pl) 2015-12-31
TWI665303B (zh) 2019-07-11
ME02271B (me) 2016-02-20
AU2016204983B2 (en) 2018-02-15
RS54231B1 (en) 2015-12-31
CN103370078A (zh) 2013-10-23
EP2959916A1 (en) 2015-12-30
CY1116835T1 (el) 2017-03-15
KR20140006040A (ko) 2014-01-15
KR102183276B1 (ko) 2020-11-26
HRP20151031T1 (hr) 2015-11-06
AR117530A2 (es) 2021-08-11
TW201300538A (zh) 2013-01-01
UA112768C2 (uk) 2016-10-25
KR102073075B1 (ko) 2020-02-26
MX355058B (es) 2018-04-04
PT2959916T (pt) 2018-11-19
AU2016204983A1 (en) 2016-08-04
WO2012110489A2 (en) 2012-08-23
JP5788027B2 (ja) 2015-09-30
EA038012B1 (ru) 2021-06-23
MX2013009485A (es) 2014-07-09
TWI673362B (zh) 2019-10-01
BR112013021076B1 (pt) 2022-11-29
MY186535A (en) 2021-07-26
PT2675475E (pt) 2015-10-22
DK2959916T3 (en) 2018-10-29
BR112013021076A2 (pt) 2020-12-15
PH12017500962A1 (en) 2017-11-20
AU2012217169B2 (en) 2016-08-11
ES2550258T3 (es) 2015-11-05
SI2675475T1 (sl) 2015-10-30

Similar Documents

Publication Publication Date Title
PL2959916T3 (pl) Nowy europejski szczep prrsv
DK3505720T3 (en) Cementering under styret tryk
PL3138672T3 (pl) Maszyna przekształcająca
ZA201400381B (en) Windbreak system
GB201011502D0 (en) Novel process
HU1000010D0 (en) Novel process
EP2669643A4 (en) MORE HEAD SCALE
HU1000386D0 (en) Novel process
GB201009673D0 (en) Novel process
GB201009676D0 (en) Novel process
EP2693175A4 (en) MORE HEAD SCALE
GB201009671D0 (en) Novel process
EP2663331A4 (en) NEW USES
EP2760803A4 (en) PRODUCT IN GEOPOLYMER
GB201301300D0 (en) No details
GB201119167D0 (en) Novel bachteriophages
GB201213822D0 (en) Checkweigher
PT2571902T (pt) Novo processo.
EP2672239A4 (en) BALANCE OF COMBINATION
SG11201400407YA (en) Mold
PL2610595T3 (pl) Platforma ważąca
EP2617548A4 (en) SHAPE
GB201110287D0 (en) Novel aggregates
GB201109281D0 (en) Membrane
GB201119600D0 (en) Strain indicator