HRP20151031T1 - Novi europski soj prrsv - Google Patents
Novi europski soj prrsv Download PDFInfo
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- HRP20151031T1 HRP20151031T1 HRP20151031TT HRP20151031T HRP20151031T1 HR P20151031 T1 HRP20151031 T1 HR P20151031T1 HR P20151031T T HRP20151031T T HR P20151031TT HR P20151031 T HRP20151031 T HR P20151031T HR P20151031 T1 HRP20151031 T1 HR P20151031T1
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- Prior art keywords
- prrsv
- virus
- ecacc
- vaccine
- cncm
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- 229960005486 vaccine Drugs 0.000 claims 14
- 241000700605 Viruses Species 0.000 claims 13
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 10
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 claims 8
- 241000282898 Sus scrofa Species 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 241000894007 species Species 0.000 claims 3
- 241000606748 Actinobacillus pleuropneumoniae Species 0.000 claims 2
- 241000588779 Bordetella bronchiseptica Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 241000606807 Glaesserella parasuis Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241000204045 Mycoplasma hyopneumoniae Species 0.000 claims 2
- 241000606856 Pasteurella multocida Species 0.000 claims 2
- 241000125945 Protoparvovirus Species 0.000 claims 2
- 241000607142 Salmonella Species 0.000 claims 2
- 241000194021 Streptococcus suis Species 0.000 claims 2
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 claims 2
- 241000282887 Suidae Species 0.000 claims 2
- 241000711484 Transmissible gastroenteritis virus Species 0.000 claims 2
- 230000000890 antigenic effect Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 229940051027 pasteurella multocida Drugs 0.000 claims 2
- 230000001850 reproductive effect Effects 0.000 claims 2
- 230000000241 respiratory effect Effects 0.000 claims 2
- 201000010740 swine influenza Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 241000710788 Lelystad virus Species 0.000 claims 1
- 230000006978 adaptation Effects 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
- C12N2770/10064—Methods of inactivation or attenuation by serial passage
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10071—Demonstrated in vivo effect
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Claims (21)
1. Reproduktivni virus i virus respiratornog sindroma kod svinja (PRRSV) europske vrste, naznačen time, da je od soja deponiranog u Europskoj kolekciji staničnih kultura (ECACC) pod Pristupnim brojem ECACC 11012501.
2. Reproduktivni virus i virus respiratornog sindroma kod svinja (PRRSV) europske vrste, naznačen time, da je od soja deponiranog u Europskoj kolekciji staničnih kultura (ECACC) pod Pristupnim brojem ECACC 11012502.
3. PRRSV prema zahtjevu 2, naznačen time, da je spomenuti virus razblažen prolaženjem najmanje 36 puta u staničnoj kulturi, tako da, kada se modificirani virus daje svinji ili nekom drugom sisavcu sa sklonošću na PRRSV, tada on ne pokazuje kliničke znakove PRRSV-bolesti, ali je sposoban inducirati imunološku reakciju koja imunizira sisavca protiv patogenih oblika od PRRSV.
4. Postupak proizvodnje živog razblaženog PRRSV prema zahtjevu 2, naznačen time, da obuhvaća prilagodbu od MA 104 odraslog PRRSV europske vrste prema zahtjevu 1, na ne-MA 104-stanice sisavaca.
5. Cjepivo za zaštitu svinja protiv PRRSV-infekcije, naznačeno time, da obuhvaća živi razblaženi PRRSV prema zahtjevu 2, i jedan farmaceutski prihvatljiv nosač.
6. Cjepivo prema zahtjevu 5, naznačeno time, da nadalje obuhvaća jedan ili više ne-PRRSV razblaženih ili deaktiviranih patogena ili njihov antigenski materijal.
7. Cjepivo prema zahtjevu 6, naznačeno time, da su navedeni ne-PRRSV patogeni odabrani od sljedećih: pseudorabijski virus, virus svinjske gripe, svinjski parvovirus, virus transmisijskog gastroenteritisa, escherichia coli, erysipelo rhusiopathiae, bordetella bronchiseptica, salmonella cholerasuis, haemophilus parasuis, pasteurella multocida, streptococcus suis, mycoplasma hyopneumoniae, i actinobacillus pleuropneumoniae.
8. Cjepivo prema zahtjevu 5, naznačeno time, da nadalje obuhvaća jedan ili više dodatnih europskih sojeva PRRSV, odabranih iz skupine koja se sastoji od PRRSV soja deponiranog pod Pristupnim brojevima soja virusa Lelystad (Lelystad agens (CDI-NL-2.91)), ili drugih sojeva kao što su oni deponirani pod Pristupnim brojevima ECACC 04102703, ECACC 04102702, ECACC 04102704, CNCM Pristupni br. I-1140, CNCM Pristupni br. I-1387, CNCM Pristupni br. I-1388, ATCC VR 2332, VR 2385, VR 2386, VR 2429, VR 2474, i VR 2402; CNCM I-1102, CNCM I-1140, CNCM I-1387, CNCM I-1388, ili ECACC V93070108, ili US-soja kao što je Sjevernoamerički PRRS virus, pT7P129A; ATCC polog VR-2332, ATCC polog VR-2368; ATCC VR-2495; ATCC VR-2385, ATCC VR-2386, ATCC VR-2429, ATCC VR-2474, i ATCC VR-2402.
9. Cjepivo prema zahtjevu 5, naznačeno time, da obuhvaća nosač koji je prikladan za intradermalnu ili intramuskularnu primjenu.
10. Cjepivo prema zahtjevu 5, naznačeno time, da je ono u osušenom obliku zamrzavanjem.
11. Cjepivo prema zahtjevu 5, naznačeno time, da spomenuto cjepivo sadrži najmanje 107 čestica virusa.
12. Postupak proizvodnje živog razblaženog cjepiva za borbu protiv PRRS, naznačen time, da obuhvaća sastavljanje živog razblaženog PRRSV prema zahtjevu 2, s jednim farmaceutski prihvatljivim nosačem.
13. Postupak prema zahtjevu 12, naznačen time, da živi razblaženi PRRSV nadalje sadrži jedan ili više dodatnih europskih sojeva PRRSV, odabranih iz skupine koja se sastoji od PRRSV soja deponiranog pod Pristupnim brojevima ECACC 04102703, ECACC 04102702, ECACC 04102704, CNCM Pristupni br. I-1140, CNCM Pristupni br. I-1387, i CNCM Pristupni br. I-1388.
14. Postupak prema zahtjevu 12, naznačen time, da živi razblaženi PRRSV nadalje sadrži pomoćno sredstvo.
15. Cjepivo prema bilo kojem od zahtjeva 5 do 11, naznačeno time, da se upotrebljava u postupku imunizacije svinje protiv reproduktivnog i respiratornog sindroma kod svinja (PRRS).
16. Cjepivo za uporabu prema zahtjevu 15, naznačeno time, da kod spomenute svinje nisu prisutne lezije na plućima nakon cijepljenja.
17. PRRS-virus, naznačen time, da ima nukleotidnu sekvencu koja je najmanje 95% homologna sa sekvencom prikazanom u bilo kojoj od SEQ ID NO:1 ili SEQ ID NO:10.
18. PRRS-virus prema zahtjevu 17, naznačen time, da ima nukleotidnu sekvencu koja je prikazana u bilo kojoj od SEQ ID NO:1 ili SEQ ID NO:10.
19. Cjepivo za zaštitu svinja protiv PRRSV-infekcije, naznačeno time, da obuhvaća PRRS virus prema zahtjevu 17 ili 18 i jedan farmaceutski prihvatljiv nosač, pri čemu navedeni PRRS virus ima nukleotidnu sekvencu prikazanu u SEQ ID NO:1, ili je to razblaženi PRRS virus koji ima nukleotidnu sekvencu koja je najmanje 95% homologna sa sekvencom prikazanom u SEQ ID NO:1.
20. Cjepivo prema zahtjevu 19, naznačeno time, da nadalje obuhvaća jedan ili više ne-PRRSV razblaženih ili deaktiviranih patogena ili njihov antigenski materijal.
21. Cjepivo prema zahtjevu 20, naznačeno time, da su navedeni ne-PRRSV patogeni odabrani od sljedećih: pseudorabijski virus, virus svinjske gripe, svinjski parvovirus, virus transmisijskog gastroenteritisa, escherichia coli, erysipelo rhusiopathiae, bordetella bronchiseptica, salmonella cholerasuis, haemophilus parasuis, pasteurella multocida, streptococcus suis, mycoplasma hyopneumoniae, i actinobacillus pleuropneumoniae.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161444074P | 2011-02-17 | 2011-02-17 | |
| PCT/EP2012/052475 WO2012110489A2 (en) | 2011-02-17 | 2012-02-14 | Novel european prrsv strain |
| EP12704409.7A EP2675475B1 (en) | 2011-02-17 | 2012-02-14 | Novel european prrsv strain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20151031T1 true HRP20151031T1 (hr) | 2015-11-06 |
Family
ID=45614840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20151031TT HRP20151031T1 (hr) | 2011-02-17 | 2015-09-29 | Novi europski soj prrsv |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US8765142B2 (hr) |
| EP (2) | EP2959916B1 (hr) |
| JP (1) | JP5788027B2 (hr) |
| KR (2) | KR102183276B1 (hr) |
| CN (2) | CN103370078B (hr) |
| AR (2) | AR085272A1 (hr) |
| AU (2) | AU2012217169B2 (hr) |
| BR (2) | BR112013021076B1 (hr) |
| CA (1) | CA2826341C (hr) |
| CL (1) | CL2013002379A1 (hr) |
| CO (1) | CO6791570A2 (hr) |
| CY (1) | CY1116835T1 (hr) |
| DK (2) | DK2675475T3 (hr) |
| EA (2) | EA035624B1 (hr) |
| ES (2) | ES2692809T3 (hr) |
| HR (1) | HRP20151031T1 (hr) |
| HU (1) | HUE027731T2 (hr) |
| ME (1) | ME02271B (hr) |
| MX (2) | MX345188B (hr) |
| MY (2) | MY186535A (hr) |
| PH (1) | PH12017500962A1 (hr) |
| PL (2) | PL2959916T3 (hr) |
| PT (2) | PT2959916T (hr) |
| RS (1) | RS54231B1 (hr) |
| SG (1) | SG192820A1 (hr) |
| SI (1) | SI2675475T1 (hr) |
| SM (1) | SMT201500236B (hr) |
| TW (2) | TWI665303B (hr) |
| UA (2) | UA117272C2 (hr) |
| WO (1) | WO2012110489A2 (hr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2675476T3 (en) | 2011-02-17 | 2015-12-14 | Boehringer Ingelheim Vetmed | Process for producing PRRSV on a commercial scale |
| ME02271B (me) | 2011-02-17 | 2016-02-20 | Boehringer Ingelheim Vetmedica Gmbh | Novi evropski prrsv soj |
| US8906385B2 (en) | 2011-12-01 | 2014-12-09 | University Of Maryland, College Park | Interferon-inducing porcine reproductive and respiratory syndrome virus isolate |
| KR102012109B1 (ko) | 2012-05-17 | 2019-08-19 | 조에티스 엘엘씨 | 이유 전 돼지 생식기 호흡기 증후군(prrs) 바이러스에 대한 효과적인 백신접종 |
| US9314519B2 (en) | 2012-08-21 | 2016-04-19 | Intervet Inc. | Liquid stable virus vaccines |
| US9457073B2 (en) * | 2012-09-26 | 2016-10-04 | University Of Manitoba | Live attenuated replication-competent arteriviruses having decreased dub/deisgylating activity |
| EP2929018A4 (en) | 2012-12-07 | 2016-07-13 | Univ Illinois | PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS COMPOSITION AND USES THEREOF |
| US9393298B2 (en) | 2013-03-15 | 2016-07-19 | Intervet Inc. | Liquid stable bovine virus vaccines |
| US9480739B2 (en) | 2013-03-15 | 2016-11-01 | Intervet Inc. | Bovine virus vaccines that are liquid stable |
| AR097762A1 (es) | 2013-09-27 | 2016-04-13 | Intervet Int Bv | Formulaciones secas de vacunas que son estables a temperatura ambiente |
| HUE061768T2 (hu) * | 2013-12-20 | 2023-08-28 | Boehringer Ingelheim Vetmedica Gmbh | PRRS virus variáns, európai PRRS virus cDNS klón, és alkalmazásuk |
| US10280199B2 (en) | 2014-02-07 | 2019-05-07 | Phibro Animal Health Corporation | Coronavirus proteins and antigens |
| AR099470A1 (es) | 2014-02-17 | 2016-07-27 | Intervet Int Bv | Vacunas de virus de aves de corral líquidas |
| TWI670085B (zh) * | 2014-02-19 | 2019-09-01 | 荷蘭商英特威國際公司 | 液體穩定之豬病毒疫苗 |
| JP6680777B2 (ja) * | 2014-10-27 | 2020-04-15 | ファーマコスモス ホールディング エー／エス | 妊娠非ヒト哺乳動物における貧血の治療又は予防 |
| CN106924726B (zh) * | 2015-12-29 | 2021-02-09 | 普莱柯生物工程股份有限公司 | 一种用于预防猪繁殖与呼吸综合征的疫苗组合物及其制备方法和应用 |
| US10279031B2 (en) | 2016-05-11 | 2019-05-07 | Phibro Animal Health Corporation | Composition comprising antigens and a mucosal adjuvant and a method for using |
| CA3022006A1 (en) * | 2016-05-11 | 2017-11-16 | Phibro Animal Health Corporation | A composition comprising antigens and a mucosal adjuvant and a method for using |
| MX2019005136A (es) | 2016-11-03 | 2019-06-20 | Boehringer Ingelheim Vetmedica Gmbh | Vacuna contra el parvovirus porcino y el virus del sindrome respiratorio reproductivo porcino y metodos de produccion de esta. |
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