AR117530A2 - Una composición que comprende un virus del síndrome reproductor y respiratorio porcino (prrsv) de un tipo europeo, un producto de vacuna, una composición de proteína, un ácido nucleico aislado y un vector de expresión recombinante - Google Patents

Una composición que comprende un virus del síndrome reproductor y respiratorio porcino (prrsv) de un tipo europeo, un producto de vacuna, una composición de proteína, un ácido nucleico aislado y un vector de expresión recombinante

Info

Publication number
AR117530A2
AR117530A2 ARP190103882A ARP190103882A AR117530A2 AR 117530 A2 AR117530 A2 AR 117530A2 AR P190103882 A ARP190103882 A AR P190103882A AR P190103882 A ARP190103882 A AR P190103882A AR 117530 A2 AR117530 A2 AR 117530A2
Authority
AR
Argentina
Prior art keywords
seq
prrsv
nucleic acid
composition
virus
Prior art date
Application number
ARP190103882A
Other languages
English (en)
Inventor
Eric Martin Vaughn
Philip Utley
Michael B Roof
Michael Dennis Piontkowski
Stefan Pesch
Francois Orveillon
- Ohlinger Volker Xavier
Sarah M Layton
Jeremy Kroll
Kim Burgard
Original Assignee
Boehringer Ingelheim Vetmedica Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmedica Gmbh filed Critical Boehringer Ingelheim Vetmedica Gmbh
Publication of AR117530A2 publication Critical patent/AR117530A2/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10021Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10061Methods of inactivation or attenuation
    • C12N2770/10064Methods of inactivation or attenuation by serial passage
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10071Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicación 1: Una composición, caracterizada porque comprende un virus del síndrome reproductor y respiratorio porcino (PRRSV) de un tipo europeo, que es de la cepa depositada en la Colección europea de cultivos celulares (ECACC) con el número de acceso ECACC 11012502. Reivindicación 5: La composición según cualquiera de las reivindicaciones 1 a 4, caracterizada porque además comprende uno o más patógenos atenuados o inactivados no PRRSV o material antigénico del mismo. Reivindicación 6: La composición según la reivindicación 5, caracterizada porque dichos patógenos no PRRSV se seleccionan de virus de la seudorrabia, virus de la gripe porcina, parvovirus porcino, virus de la gastroenteritis transmisible, Escherichia coli, Erysipelas rhusiopathiae, Bordetella bronchiseptica, Salmonella choleraesuis, Haemophilus parasuis, Pasteurella multocida, Streptococcus suis, Mycoplasma hyopneumoniae y Actinobacillus pleuropneumoniae. Reivindicación 13: Un producto de vacuna, caracterizado porque comprende en recipientes separados una composición liofilizada de acuerdo con cualquiera de las reivindicaciones 1 a 7, y un disolvente para reconstitución, y que opcionalmente contiene adicionalmente un prospecto o etiqueta que comprende instrucciones de uso. Reivindicación 15: Una composición de proteína que comprende una proteína que tiene la secuencia de SEQ ID Nº 7, o las proteínas que tienen las secuencias de SEQ ID Nº 2; SEQ ID Nº 3; SEQ ID Nº 4; SEQ ID Nº 5; SEQ ID Nº 6; SEQ ID Nº 7; SEQ ID Nº 8 y SEQ ID Nº 9. Reivindicación 18: El vector de expresión recombinante según la reivindicación 17, caracterizado porque (i) dicha secuencia de ácido nucleico que codifica dicho ORF es SEQ ID Nº 24, o (ii) dicha secuencia de ácido nucleico que codifica dichos ORFs comprende SEQ ID Nº 19; SEQ ID Nº 20, SEQ ID Nº 21; SEQ ID Nº 22; SEQ ID Nº 23; SEQ ID Nº 24; SEQ ID Nº 25 y SEQ ID Nº 26.
ARP190103882A 2011-02-17 2019-12-30 Una composición que comprende un virus del síndrome reproductor y respiratorio porcino (prrsv) de un tipo europeo, un producto de vacuna, una composición de proteína, un ácido nucleico aislado y un vector de expresión recombinante AR117530A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161444074P 2011-02-17 2011-02-17

Publications (1)

Publication Number Publication Date
AR117530A2 true AR117530A2 (es) 2021-08-11

Family

ID=45614840

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP120100538A Pending AR085272A1 (es) 2011-02-17 2012-02-16 Cepa del prrsv (virus del sindrome reproductor y respiratorio porcino) europea
ARP190103882A AR117530A2 (es) 2011-02-17 2019-12-30 Una composición que comprende un virus del síndrome reproductor y respiratorio porcino (prrsv) de un tipo europeo, un producto de vacuna, una composición de proteína, un ácido nucleico aislado y un vector de expresión recombinante

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP120100538A Pending AR085272A1 (es) 2011-02-17 2012-02-16 Cepa del prrsv (virus del sindrome reproductor y respiratorio porcino) europea

Country Status (30)

Country Link
US (4) US8765142B2 (es)
EP (2) EP2959916B1 (es)
JP (1) JP5788027B2 (es)
KR (2) KR102073075B1 (es)
CN (2) CN103370078B (es)
AR (2) AR085272A1 (es)
AU (2) AU2012217169B2 (es)
BR (2) BR112013021076B1 (es)
CA (1) CA2826341C (es)
CL (1) CL2013002379A1 (es)
CO (1) CO6791570A2 (es)
CY (1) CY1116835T1 (es)
DK (2) DK2959916T3 (es)
EA (2) EA035624B1 (es)
ES (2) ES2550258T3 (es)
HR (1) HRP20151031T1 (es)
HU (1) HUE027731T2 (es)
ME (1) ME02271B (es)
MX (2) MX345188B (es)
MY (2) MY161198A (es)
PH (1) PH12017500962A1 (es)
PL (2) PL2675475T3 (es)
PT (2) PT2959916T (es)
RS (1) RS54231B1 (es)
SG (1) SG192820A1 (es)
SI (1) SI2675475T1 (es)
SM (1) SMT201500236B (es)
TW (2) TWI665303B (es)
UA (2) UA117272C2 (es)
WO (1) WO2012110489A2 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2959916T3 (en) 2011-02-17 2018-10-29 Boehringer Ingelheim Vetmedica Gmbh New European PRRSV strain.
CA2827337C (en) 2011-02-17 2019-07-09 Boehringer Ingelheim Vetmedica Gmbh Commercial scale process for production of prrsv
US8906385B2 (en) 2011-12-01 2014-12-09 University Of Maryland, College Park Interferon-inducing porcine reproductive and respiratory syndrome virus isolate
JP6386999B2 (ja) 2012-05-17 2018-09-05 ゾエティス・エルエルシー ブタ生殖および呼吸症候群(prrs)ウイルスに対する離乳前の効果的なワクチン接種
US9314519B2 (en) 2012-08-21 2016-04-19 Intervet Inc. Liquid stable virus vaccines
US9457073B2 (en) 2012-09-26 2016-10-04 University Of Manitoba Live attenuated replication-competent arteriviruses having decreased dub/deisgylating activity
CN105308178B (zh) * 2012-12-07 2019-06-07 伊利诺伊大学评议会 猪繁殖与呼吸综合征病毒组合物及其用途
US9393298B2 (en) 2013-03-15 2016-07-19 Intervet Inc. Liquid stable bovine virus vaccines
US9480739B2 (en) 2013-03-15 2016-11-01 Intervet Inc. Bovine virus vaccines that are liquid stable
AR097762A1 (es) 2013-09-27 2016-04-13 Intervet Int Bv Formulaciones secas de vacunas que son estables a temperatura ambiente
HUE061768T2 (hu) * 2013-12-20 2023-08-28 Boehringer Ingelheim Vetmedica Gmbh PRRS virus variáns, európai PRRS virus cDNS klón, és alkalmazásuk
US10280199B2 (en) 2014-02-07 2019-05-07 Phibro Animal Health Corporation Coronavirus proteins and antigens
AR099470A1 (es) 2014-02-17 2016-07-27 Intervet Int Bv Vacunas de virus de aves de corral líquidas
TWI670085B (zh) * 2014-02-19 2019-09-01 荷蘭商英特威國際公司 液體穩定之豬病毒疫苗
US11040059B2 (en) 2014-10-27 2021-06-22 Pharmacosmos Holding A/S Treatment or prevention of anaemia in pregnant non-human mammals
CN106924726B (zh) * 2015-12-29 2021-02-09 普莱柯生物工程股份有限公司 一种用于预防猪繁殖与呼吸综合征的疫苗组合物及其制备方法和应用
US10279031B2 (en) 2016-05-11 2019-05-07 Phibro Animal Health Corporation Composition comprising antigens and a mucosal adjuvant and a method for using
WO2017196318A1 (en) * 2016-05-11 2017-11-16 Phibro Animal Health Corporation A composition comprising antigens and a mucosal adjuvant and a method for using
PT3534939T (pt) 2016-11-03 2023-04-20 Boehringer Ingelheim Vetmedica Gmbh Vacina contra parvovírus porcino e vírus da síndrome reprodutiva e respiratória porcina e métodos da sua produção
CA3047294A1 (en) * 2016-12-14 2018-06-21 Zoetis Services Llc Effective vaccination against european strains of porcine reproductive and respiratory syndrome (prrs) virus prior to weaning
US11013796B2 (en) 2018-08-30 2021-05-25 Iowa State University Research Foundation, Inc. Porcine parainfluenza virus type 1 isolates and immunogenic compositions therefrom
CN114222579A (zh) 2019-04-04 2022-03-22 勃林格殷格翰动物保健美国有限公司 猪圆环病毒3型(pcv3)疫苗及其生产和用途
CN110735005B (zh) * 2019-11-26 2023-01-10 广西大学 Siv和prrsv多重rt-pcr快速检测试剂盒及引物
CN111676247A (zh) * 2020-06-30 2020-09-18 扬州大学 一株猪繁殖与呼吸综合征病毒1型分离株感染性克隆构建、拯救与应用
MX2023001024A (es) 2020-07-24 2023-02-15 Boehringer Ingelheim Animal Health Usa Inc Vacuna porcina combinada.
CN113862230B (zh) * 2021-09-30 2023-08-08 中牧实业股份有限公司 一种猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用

Family Cites Families (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE148705C (es)
US3137631A (en) 1959-12-01 1964-06-16 Faberge Inc Encapsulation in natural products
US3080291A (en) 1960-06-10 1963-03-05 Jensen Salsberg Lab Inc Serial passage of distemper virus in tissue cultures of chick embryo and canine tissue and vaccine therefrom
US3959457A (en) 1970-06-05 1976-05-25 Temple University Microparticulate material and method of making such material
US4015100A (en) 1974-01-07 1977-03-29 Avco Everett Research Laboratory, Inc. Surface modification
US4122167A (en) 1977-02-09 1978-10-24 Merck & Co., Inc. Respiratory synctial vaccine
US4205060A (en) 1978-12-20 1980-05-27 Pennwalt Corporation Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use
US4224412A (en) 1979-05-01 1980-09-23 Dorofeev Viktor M Living virus culture vaccine against canine distemper and method of preparing same
US4554159A (en) 1981-11-12 1985-11-19 Institute Merieux Vaccine and method of immunizing against herpes simplex virus (types 1 and 2)
US4452747A (en) 1982-03-22 1984-06-05 Klaus Gersonde Method of and arrangement for producing lipid vesicles
GB8319302D0 (en) 1983-07-16 1983-08-17 Tpt Ltd Container
US4468346A (en) 1983-10-27 1984-08-28 The United States Of America As Represented By The Secretary Of Agriculture Monoclonal antibodies to porcine immunoglobulins
DE3405100A1 (de) 1984-02-14 1985-08-14 Drägerwerk AG, 2400 Lübeck Pt-katalysator auf einem traeger als luftreinigungsmittel
US4744933A (en) 1984-02-15 1988-05-17 Massachusetts Institute Of Technology Process for encapsulation and encapsulated active material system
US5008050A (en) 1984-06-20 1991-04-16 The Liposome Company, Inc. Extrusion technique for producing unilamellar vesicles
US4921706A (en) 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US4606940A (en) 1984-12-21 1986-08-19 The Ohio State University Research Foundation Small particle formation and encapsulation
US5206163A (en) 1985-07-08 1993-04-27 Chiron Corporation DNA encoding bovine diarrhea virus protein
DE3687769T2 (de) 1985-07-08 1993-09-02 Wallone Region Vakzine und diagnostika, die vom bovine-diarrhea-virus stammen.
US4753884A (en) 1986-01-28 1988-06-28 Novagene, Inc. Pseudorabies virus mutants, vaccines containing same, methods for the production of same and methods for the use of same
JPS62198626A (ja) 1986-02-26 1987-09-02 Biseibutsu Kagaku Kenkyusho:Kk 血球凝集性脳脊髄炎ウイルス感染症予防ワクチン
FR2602791B1 (fr) 1986-08-18 1988-11-10 Ministere Agri Direction Quali Procede de culture du virus de la rhinotracheite infectieuse de la dinde, et vaccin prepare a partir du virus ainsi obtenu
NZ222465A (en) 1986-11-07 1992-11-25 Pasteur Institut Nanb (non a, non b hepatitis viral) antigen
US5009956A (en) 1987-02-24 1991-04-23 Univ Minnesota Phospholipase A2-resistant liposomes
DE3833925A1 (de) 1988-03-11 1989-09-21 Inst Angewandte Biotechnologie Verfahren und herstellung von virus und viralem antigen und vorrichtung hierzu
US5213759A (en) 1988-05-05 1993-05-25 Elopak Systems A.G. Sterilization
US4927637A (en) 1989-01-17 1990-05-22 Liposome Technology, Inc. Liposome extrusion method
US4944948A (en) 1989-02-24 1990-07-31 Liposome Technology, Inc. EGF/Liposome gel composition and method
US5132117A (en) 1990-01-11 1992-07-21 Temple University Aqueous core microcapsules and method for their preparation
AU7007491A (en) 1990-02-02 1991-08-08 Schweiz. Serum- & Impfinstitut Bern Cdna corresponding to the genome of negative-strand rna viruses, and process for the production of infectious negative-strand rna viruses
DK0587780T4 (da) 1991-06-06 2008-10-13 Boehringer Ingelheim Vetmed Smitstof, som forårsager Mystery Swine Disease,vaccinepræparater og diagnostiske sæt
ATE144144T1 (de) 1991-08-26 1996-11-15 James Edward Collins Vakzine gegen und diagnosemethode für das schweine-unfruchtbarkeits- und atmungs-syndrom (suas)
US6042830A (en) 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
US6080570A (en) 1991-08-26 2000-06-27 Boehringer Ingelheim Vetmedica, Inc. Method of producing a vaccine for Swine Infertility and Respiratory Syndrome
US5846805A (en) 1991-08-26 1998-12-08 Boehringer Ingelheim Animal Health, Inc. Culture of swine infertility and respiratory syndrome virus in simian cells
US6982160B2 (en) 1991-08-26 2006-01-03 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions that include SIRS virus
MX9204885A (es) 1991-08-26 1994-05-31 Boehringer Animal Health Inc Composicion de vacuna que comprende virus del sindrome de infertilidad y respiratorio de los cerdos.
AU2696792A (en) 1991-09-16 1993-04-27 David A Benfield Vaccine for mystery swine disease and method for diagnosis thereof
DE69206631T2 (de) 1991-10-14 1996-05-15 Akzo Nobel Nv Impfstoff gegen das Fortpflanzungs- und Atmungssyndrom bei Schweinen (PRRS) und Diagnose.
FR2686097B1 (fr) 1992-01-14 1994-12-30 Rhone Merieux Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie.
US5338543A (en) 1992-02-27 1994-08-16 Ambico, Inc. Thimerosal inactivated mycoplasma hyopneumoniae vaccine
TW289731B (es) 1992-07-09 1996-11-01 Akzo Nv
US6592873B1 (en) 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
US6251397B1 (en) 1992-10-30 2001-06-26 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same
US6773908B1 (en) 1992-10-30 2004-08-10 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US6380376B1 (en) 1992-10-30 2002-04-30 Iowa State University Research Foundation Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US5695766A (en) 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
US5419907A (en) 1992-11-10 1995-05-30 Iowa State University Research Foundation, Inc. Pathogenic porcine respiratory coronavirus
CN1080300C (zh) 1993-02-08 2002-03-06 美国拜尔公司 培养猪生殖和呼吸综合症病毒的方法及其在疫苗中的应用
ES2074950B1 (es) 1993-09-17 1996-03-16 Iberica Cyanamid Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda.
EP0659885A1 (en) 1993-12-21 1995-06-28 Akzo Nobel N.V. Vaccine against viruses associated with antibody-dependent-enhancement of viral infectivity
DE4407489A1 (de) 1994-03-07 1995-09-14 Bayer Ag Vakzine zur Prävention von Respirations- und Reproduktionserkrankungen des Schweines
PT676467E (pt) 1994-04-11 2002-02-28 Akzo Nobel Nv Estirpes europeias de vacina do virus do sindroma reprodutivo e respiratorio porcino (prrsv)
AU2386595A (en) 1994-04-15 1995-11-10 Children's Hospital Of Philadelphia, The Aqueous solvent encapsulation method, apparatus and microcapsules
DK53595A (da) 1994-05-13 1995-11-14 Iberica Cyanamid Rekombinante PRRSV-proteiner, diagnostiske kits og vaccine indeholdende sådanne rekombinante PRRSV-proteiner
PT783321E (pt) 1994-08-05 2006-08-31 Univ Minnesota Sequencia nucleotidica viral vr-2332 e metodos de utilizacao
EP0732340B1 (en) 1995-03-14 2004-06-09 Akzo Nobel N.V. Expression of porcine reproductive respiratory syndrome virus polypeptides in the same cell
US5690940A (en) 1995-06-21 1997-11-25 Regents Of The University Of Minnesota Low pathogencity PRRS live virus vaccines and methods of preparation thereof
ES2102971B1 (es) 1996-01-25 1998-03-01 Hipra Lab Sa Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion.
US6015663A (en) 1996-03-01 2000-01-18 The United States Of America As Represented By The Secretary Of Agriculture Restriction enzyme screen for differentiating porcine reproductive and respiratory syndrome virus strains
EP0894007A1 (en) 1996-03-01 1999-02-03 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
US5866401A (en) 1996-03-01 1999-02-02 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
US5976537A (en) 1996-07-02 1999-11-02 The United States Of America As Represented By The Secretary Of Agriculture Porcine reproductive and respiratory syndrome vaccine
ES2157522T3 (es) 1996-10-09 2001-08-16 Akzo Nobel Nv Cepas de vacunas europeas del virus del sindrome respiratorio reproductor porcino (prrsv).
US20040224327A1 (en) 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
EP0839912A1 (en) 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
WO1998035023A1 (en) 1997-02-07 1998-08-13 Origen, Inc. Method for growing porcine reproductive and respiratory syndrome virus for use as vaccines and diagnostic assays
ID23399A (id) 1997-05-06 2000-04-20 Stichting Dienst Landbouwkundi Situs antigenik prrsv untuk mengidentifikasi urutan peptida dari virus prrs yang digunakan untuk vaksin atau pengujian diagnostik
US6140486A (en) 1997-06-04 2000-10-31 Calgene Llc Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants
AU7960598A (en) 1997-06-05 1998-12-21 Origen, Inc. Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine
US6391314B1 (en) 1997-10-03 2002-05-21 Merial Porcine circoviruses vaccines diagnostic reagents
US7211379B2 (en) 1997-10-03 2007-05-01 Merial Sas Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2
CA2440933A1 (en) 1998-12-22 2000-06-22 Pfizer Products Inc. An infectious cdna clone of north american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof
US7618797B2 (en) 1998-12-22 2009-11-17 Pfizer Inc Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7132106B2 (en) 1998-12-22 2006-11-07 Pfizer Inc. Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7691389B2 (en) 1998-12-22 2010-04-06 Pfizer Inc Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
FR2789695B1 (fr) 1999-02-11 2003-03-07 Merial Sas Vecteurs et vaccins viraux a base d'adenovirus porcins recombines et replicatifs
EP1157121B1 (en) 1999-03-08 2013-04-24 Boehringer Ingelheim Vetmedica GmbH Prrsv replicon
DK2251419T3 (da) 1999-04-22 2012-07-02 Us Agriculture Porcint reproduktions- og respirations-syndrom-vaccine baseret på isolat JA-142
US20040213805A1 (en) 1999-10-12 2004-10-28 Verheije Monique Helene Deletions in arterivirus replicons
US20020012670A1 (en) 2000-01-26 2002-01-31 Knut Elbers Recombinant attenuation of porcine reproductive and respiratory syndrome (PRRSV)
DE60121545T2 (de) * 2000-02-08 2007-06-28 Regents Of The University Of Minnesota, Minneapolis Virus des porcinen reproduktiven und respiratorischen syndroms und dessen verwendung
EP1156111A1 (en) 2000-05-19 2001-11-21 Stichting Dienst Landbouwkundig Onderzoek Chimeric arterivirus-like particles
US7018638B2 (en) 2000-12-19 2006-03-28 Wyeth Mycoplasma hyopneumoniae bacterin vaccine
CA2439254A1 (en) * 2001-03-09 2002-09-19 Boehringer Ingelheim Vetmedica Gmbh Life attenuated strains of prrs virus
EP1397498A1 (en) 2001-05-21 2004-03-17 ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. Delections in arterivirus replicons
US7279166B2 (en) 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US6841364B2 (en) 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
ATE557082T1 (de) 2002-04-05 2012-05-15 Boehringer Ingelheim Vetmed Sequenz positionen zur anpassung bei prrsv
US7335361B2 (en) 2003-06-09 2008-02-26 Animal Technology Institute Taiwan Fusion antigen used as vaccine
US7722878B2 (en) 2004-06-17 2010-05-25 Boehringer Ingelheim Vetmedica, Inc. PRRSV subunit vaccines
BRPI0510928A (pt) 2004-06-18 2007-11-13 Univ Minnesota identificação de organismos viralmente infectados e vacinados
CN101039693A (zh) * 2004-06-18 2007-09-19 明尼苏达大学董事会 鉴定病毒感染和疫苗接种的生物
US20060063151A1 (en) 2004-09-21 2006-03-23 Michael Roof Porcine reproductive and respiratory syndrome isolates and methods of use
US7632636B2 (en) 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
RU2007117510A (ru) * 2004-11-11 2008-11-20 Пфайзер Продактс Инк. (Us) Мутантный вирус репродуктивного и респираторного синдрома свиней
DE602005023342D1 (en) * 2004-11-19 2010-10-14 Intervet Int Bv S (porcine reproductive und respiratory syndrome) von schweinen
ES2343201T3 (es) 2005-01-13 2010-07-26 Boehringer Ingelheim Vetmedica Gmbh Vacunas contra el srrp.
MX2007015849A (es) 2005-06-24 2008-02-22 Univ Minnesota Virus del sindrome respiratorio y reproductivo porcino, clones infecciosos, mutantes de los mismos, y metodos de uso.
CA2903542C (en) * 2005-11-29 2019-11-26 Iowa State University Research Foundation, Inc. Identification of protective antigenic determinants of porcine reproductive and respiratory syndrome virus and uses thereof
WO2008109237A2 (en) 2007-02-13 2008-09-12 Washington State University Research Foundation Macrophage cell-lines for propagation of porcine reproductive and respiratory syndrome virus
WO2008121958A1 (en) 2007-04-02 2008-10-09 Boehringer Ingelheim Vetmedica, Inc. Use of prrsv vaccines to reduce pcv2 viremia
US20100003278A1 (en) 2008-07-03 2010-01-07 Boehringer Ingelheim Vetmedica, Inc. Immunological Compositions Effective for Lessening the Severity or Incidence of PRRSV Signs and Methods of Use Thereof
BRPI0917887A2 (pt) 2008-08-25 2019-09-03 Boehringer Ingelheim Vetmedica Inc vacina contra síndrome reprodutiva e respiratória suína altamente patogênica (hp pprs)
US20100129398A1 (en) 2008-11-26 2010-05-27 Boehringer Ingelheim Vetmedica, Inc. Materials and Methods for Control of Porcine Reproductive and Respiratory Syndrome
WO2011128415A1 (en) 2010-04-16 2011-10-20 Universiteit Gent Cross-protecting vaccine for porcine reproductive and respiratory syndrome virus
CN101920010A (zh) * 2010-06-29 2010-12-22 西北农林科技大学 表达prrsv免疫原基因的重组减毒鼠伤寒沙门氏菌载体疫苗及其制备方法
US8728487B2 (en) 2011-01-20 2014-05-20 Hua Wu Attenuated live vaccine for prevention of porcine reproductive and respiratory syndrome
CA2827337C (en) * 2011-02-17 2019-07-09 Boehringer Ingelheim Vetmedica Gmbh Commercial scale process for production of prrsv
DK2959916T3 (en) 2011-02-17 2018-10-29 Boehringer Ingelheim Vetmedica Gmbh New European PRRSV strain.
EP2737059A1 (en) 2011-07-29 2014-06-04 Boehringer Ingelheim Vetmedica GmbH Novel prrs virus inducing type i interferon in susceptible cells
US9579373B2 (en) 2013-03-15 2017-02-28 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use
HUE061768T2 (hu) 2013-12-20 2023-08-28 Boehringer Ingelheim Vetmedica Gmbh PRRS virus variáns, európai PRRS virus cDNS klón, és alkalmazásuk

Also Published As

Publication number Publication date
RS54231B1 (en) 2015-12-31
EA038012B1 (ru) 2021-06-23
WO2012110489A2 (en) 2012-08-23
KR20140006040A (ko) 2014-01-15
BR112013021076B1 (pt) 2022-11-29
TW201300538A (zh) 2013-01-01
CN106110318A (zh) 2016-11-16
JP2014507151A (ja) 2014-03-27
TWI665303B (zh) 2019-07-11
ES2692809T3 (es) 2018-12-05
EA201692359A1 (ru) 2017-04-28
AU2012217169A1 (en) 2013-07-18
KR102183276B1 (ko) 2020-11-26
CA2826341C (en) 2022-02-22
US10039821B2 (en) 2018-08-07
SG192820A1 (en) 2013-09-30
ME02271B (me) 2016-02-20
CL2013002379A1 (es) 2014-02-14
CY1116835T1 (el) 2017-03-15
KR102073075B1 (ko) 2020-02-26
AU2016204983A1 (en) 2016-08-04
MY161198A (en) 2017-04-14
US9534207B2 (en) 2017-01-03
DK2959916T3 (en) 2018-10-29
EP2675475B1 (en) 2015-07-01
TW201638333A (zh) 2016-11-01
EA035624B1 (ru) 2020-07-16
US8765142B2 (en) 2014-07-01
HRP20151031T1 (hr) 2015-11-06
MX355058B (es) 2018-04-04
PT2959916T (pt) 2018-11-19
UA112768C2 (uk) 2016-10-25
EA201300915A1 (ru) 2014-02-28
US20170065709A1 (en) 2017-03-09
DK2675475T3 (en) 2015-09-14
HUE027731T2 (en) 2016-10-28
US20140255442A1 (en) 2014-09-11
PL2959916T3 (pl) 2019-05-31
SMT201500236B (it) 2015-10-30
EP2959916A1 (en) 2015-12-30
MX345188B (es) 2017-01-20
BR112013021076A2 (pt) 2020-12-15
AU2012217169B2 (en) 2016-08-11
WO2012110489A3 (en) 2012-10-11
US20190134180A1 (en) 2019-05-09
MY186535A (en) 2021-07-26
JP5788027B2 (ja) 2015-09-30
AU2016204983B2 (en) 2018-02-15
CN103370078B (zh) 2016-08-10
CA2826341A1 (en) 2012-08-23
PT2675475E (pt) 2015-10-22
US10668144B2 (en) 2020-06-02
KR20200015800A (ko) 2020-02-12
UA117272C2 (uk) 2018-07-10
US20120213810A1 (en) 2012-08-23
SI2675475T1 (sl) 2015-10-30
MX2013009485A (es) 2014-07-09
CN103370078A (zh) 2013-10-23
EP2959916B1 (en) 2018-08-08
TWI673362B (zh) 2019-10-01
ES2550258T3 (es) 2015-11-05
CO6791570A2 (es) 2013-11-14
BR122021013826B1 (pt) 2022-11-22
AR085272A1 (es) 2013-09-18
PL2675475T3 (pl) 2015-12-31
EP2675475A2 (en) 2013-12-25
PH12017500962A1 (en) 2017-11-20

Similar Documents

Publication Publication Date Title
AR117530A2 (es) Una composición que comprende un virus del síndrome reproductor y respiratorio porcino (prrsv) de un tipo europeo, un producto de vacuna, una composición de proteína, un ácido nucleico aislado y un vector de expresión recombinante
RU2015104165A (ru) Мутантные штаммы mycoplasma hyopneumoniae
JP2015523080A5 (es)
Perez-Casal et al. Status of the development of a vaccine against Mycoplasma bovis
RU2016137121A (ru) Вакцины против вирусов свиней, стабильные в жидкой форме
RU2010112939A (ru) Снижение сопутствующих инфекций у свиней с помощью антигена pcv2
AR069216A1 (es) Composicion para provocar una respuesta inmune anti-mycoplasma hyopneumoniae y metodos
MX2022003435A (es) Desarrollo de una vacuna novedosa atenuada viva contra la peste porcina africana basada en la eliminacion del gen i177l.
AR089039A1 (es) Vectores recombinantes de hvt que expresan antigenos de patogenos de aves y sus usos
JP2016531854A5 (es)
ES2723273T3 (es) Vectores poxvirales recombinantes que expresan proteínas de la rabia y OX40 y vacunas fabricadas a partir de los mismos
RU2016144766A (ru) Парвовирус свиней
JP2016520075A5 (es)
Virginio et al. Immune responses elicited by Mycoplasma hyopneumoniae recombinant antigens and DNA constructs with potential for use in vaccination against porcine enzootic pneumonia
AR095482A1 (es) Virus del síndrome reproductivo y respiratorio porcino, composiciones, vacuna y métodos de uso
AR108014A1 (es) Vacuna universal para enfermedades virales y método de vacunación
JP2012506858A5 (es)
Zou et al. Attenuated Actinobacillus pleuropneumoniae as a bacterial vector for expression of Mycoplasma hyopneumoniae P36 gene
BR112018003580A2 (pt) molécula de ácido nucléico, método para apresentar um polipeptídeo alvo, proteína recombinante, partícula do tipo viral, composição farmacêutica, polipeptídeo, vetor, célula hospedeira e método para preparar a proteína recombinante
BR112012018457A2 (pt) peptídeos melk modificados e vacinas contendo os mesmos
Pretre et al. Characterization of LIC11207, a novel leptospiral protein that is recognized by human convalescent sera and prevents apoptosis of polymorphonuclear leukocytes
Singh et al. Molecular characterization and computational analysis of the major outer membrane protein (ompH) gene of Pasteurella multocida P52
Yuan et al. Influences of ORF1 on the virulence and immunogenicity of Actinobacillus pleuropneumoniae
Xiong et al. A porcine reproductive and respiratory syndrome virus (PRRSV) vaccine candidate based on the fusion protein of PRRSV glycoprotein 5 and the Toll-like Receptor-5 agonist Salmonella Typhimurium FljB
Tufail et al. Highly soluble and stable ‘insertion domain’of the capsid penton base protein provides complete protection against infections caused by fowl adenoviruses