RU2016137121A - Вакцины против вирусов свиней, стабильные в жидкой форме - Google Patents
Вакцины против вирусов свиней, стабильные в жидкой форме Download PDFInfo
- Publication number
- RU2016137121A RU2016137121A RU2016137121A RU2016137121A RU2016137121A RU 2016137121 A RU2016137121 A RU 2016137121A RU 2016137121 A RU2016137121 A RU 2016137121A RU 2016137121 A RU2016137121 A RU 2016137121A RU 2016137121 A RU2016137121 A RU 2016137121A
- Authority
- RU
- Russia
- Prior art keywords
- virus
- liquid
- swine
- stable
- vaccine according
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title claims 18
- 241000700605 Viruses Species 0.000 title claims 17
- 229960005486 vaccine Drugs 0.000 claims 17
- 241000282898 Sus scrofa Species 0.000 claims 16
- 230000002238 attenuated effect Effects 0.000 claims 13
- 150000005846 sugar alcohols Chemical class 0.000 claims 9
- 239000004475 Arginine Substances 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
- 241000711484 Transmissible gastroenteritis virus Species 0.000 claims 2
- 235000013922 glutamic acid Nutrition 0.000 claims 2
- 239000004220 glutamic acid Substances 0.000 claims 2
- 230000001850 reproductive effect Effects 0.000 claims 2
- 230000000241 respiratory effect Effects 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
- 241000193468 Clostridium perfringens Species 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 201000000297 Erysipelas Diseases 0.000 claims 1
- 102100038395 Granzyme K Human genes 0.000 claims 1
- 101001033007 Homo sapiens Granzyme K Proteins 0.000 claims 1
- 241001148567 Lawsonia intracellularis Species 0.000 claims 1
- 241001293418 Mannheimia haemolytica Species 0.000 claims 1
- 241000606856 Pasteurella multocida Species 0.000 claims 1
- 241000702670 Rotavirus Species 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 229940051027 pasteurella multocida Drugs 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 201000010740 swine influenza Diseases 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
- A61K39/225—Porcine transmissible gastroenteritis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Claims (16)
1. Жидкая стабильная вакцина, которая содержит живой вирус свиней, 5-40% (масс/об) сахароспирта и 0,15-0,75 М аминокислоты, выбранной из группы, состоящей из аргинина, глутаминовой кислоты и глицина; где жидкая стабильная вакцина имеет pH 6,0-8,0; где живой вирус свиней выбран из группы, состоящей из аттенуированного вируса, рекомбинантного свиного вирусного вектора и рекомбинантного вирусного вектора аттенуированного вируса свиней; и где рекомбинантный свиной вирусный вектор или рекомбинантный вирусный вектор аттенуированного вируса свиней может дополнительно кодировать гетерологичный антиген.
2. Жидкая стабильная вакцина по п.1, где сахароспиртом является сорбит.
3. Жидкая стабильная вакцина по п.1 или 2, где аминокислотой является аргинин.
4. Жидкая стабильная вакцина по любому из предыдущих пп., где живой аттенуированный вирус свиней выбран из группы, состоящей из вируса репродуктивного и респираторного синдрома свиней (РРСС), вируса эпизоотической диареи свиней (ЭДС), вируса трансмиссивного гастроэнтерита (ТГЭ), ротавируса свиней (РВС), вируса псевдобешенства свиней (ВПБС) и вируса гриппа свиней (ВГС).
5. Жидкая стабильная вакцина по любому из предыдущих пунктов, дополнительно содержащая сахарную добавку, которая является несахароспиртом, где общее количество сахароспирта и несахароспирта в жидкой стабильной вакцине составляет 15-40% (мас./об.).
6. Жидкая стабильная вакцина по любому из предыдущих пунктов, где несахароспирт выбран из группы, состоящей из сахарозы и трегалозы.
7. Жидкая стабильная вакцина по любому из предыдущих пунктов, которая дополнительно содержит буфер.
8. Жидкая стабильная вакцина по любому из предыдущих пунктов, где живым аттенуированным вирусом является РРСС.
9. Жидкая стабильная вакцина по любому из предыдущих пунктов,
которая дополнительно содержит убитый вирус свиней.
10. Жидкая стабильная вакцина по любому из предыдущих пунктов, которая дополнительно содержит бактерию.
11. Жидкая стабильная вакцина по п.10, где бактерия выбрана из группы, состоящей из живой аттенуированной Pasteurella multocida, живой аттенуированной Salmonella ssp., живой аттенуированной Mannheimia haemolytica, живой аттенуированной Clostridium perfringens, живой аттенуированной Lawsonia intracellularis, живой аттенуированной Mycoplasma hyopneumoniae, живой аттенуированной Erysipelas spp. и их любой комбинации.
12. Жидкая стабильная вакцина по любому из предыдущих пунктов, которая содержит 10-20% (мас./об.) сахароспирта и 5-15% (мас./об.) несахароспирта.
13. Способ способствования защите свиньи против вируса репродуктивного и респираторного синдрома свиней (РРСС), включающий введение свинье жидкой стабильной вакцины по любому из предыдущих пунктов.
14. Способ по п.13, где указанное введение производят пероральным, инъекционным (подкожным, внутримышечным или кожным) или назальным путем.
15. Способ получения жидкой стабильной вакцины по любому из пп.1-12, который включает объединение терапевтически эффективного количества живого аттенуированного вируса свиней с 5-40% (мас./об.) сахароспирта и 0,15-0,75 М аминокислоты, выбранной из группы, состоящей из аргинина, глутаминовой кислоты и глицина; где жидкая стабильная вакцина имеет pH 6,0-8,0.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461941720P | 2014-02-19 | 2014-02-19 | |
| US61/941,720 | 2014-02-19 | ||
| PCT/EP2015/053364 WO2015124594A1 (en) | 2014-02-19 | 2015-02-18 | Swine virus vaccines that are liquid stable |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016137121A true RU2016137121A (ru) | 2018-03-26 |
| RU2016137121A3 RU2016137121A3 (ru) | 2018-10-03 |
| RU2695523C2 RU2695523C2 (ru) | 2019-07-23 |
Family
ID=52473920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016137121A RU2695523C2 (ru) | 2014-02-19 | 2015-02-18 | Вакцины против вирусов свиней, стабильные в жидкой форме |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9855336B2 (ru) |
| EP (1) | EP3107572B1 (ru) |
| JP (1) | JP6596008B2 (ru) |
| CN (1) | CN106061503B (ru) |
| BR (1) | BR112016018871B1 (ru) |
| ES (1) | ES2793942T3 (ru) |
| RU (1) | RU2695523C2 (ru) |
| TW (1) | TWI670085B (ru) |
| WO (1) | WO2015124594A1 (ru) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9314519B2 (en) | 2012-08-21 | 2016-04-19 | Intervet Inc. | Liquid stable virus vaccines |
| US9393298B2 (en) | 2013-03-15 | 2016-07-19 | Intervet Inc. | Liquid stable bovine virus vaccines |
| US9480739B2 (en) | 2013-03-15 | 2016-11-01 | Intervet Inc. | Bovine virus vaccines that are liquid stable |
| AR097762A1 (es) | 2013-09-27 | 2016-04-13 | Intervet Int Bv | Formulaciones secas de vacunas que son estables a temperatura ambiente |
| AR099470A1 (es) | 2014-02-17 | 2016-07-27 | Intervet Int Bv | Vacunas de virus de aves de corral líquidas |
| TWI670085B (zh) * | 2014-02-19 | 2019-09-01 | 荷蘭商英特威國際公司 | 液體穩定之豬病毒疫苗 |
| WO2017162727A1 (en) * | 2016-03-23 | 2017-09-28 | Intervet International B.V. | A combination vaccine against pcv2 and prrs virus infection comprising albumin |
| JP7558638B2 (ja) * | 2016-03-23 | 2024-10-01 | インターベット インターナショナル ベー． フェー． | Ｐｃｖ２およびｐｒｒｓウイルス感染に対する皮内適用のためのワクチン |
| CN107686833B (zh) * | 2016-04-18 | 2021-02-19 | 华南农业大学 | 一种猪细小病毒毒株及其应用 |
| JP7174698B2 (ja) * | 2016-11-29 | 2022-11-17 | インターベット インターナショナル ベー． フェー． | ブタワクチン |
| NL2018155B1 (en) * | 2017-01-11 | 2018-07-25 | Intervet Int Bv | Oral vaccine against ruminant respiratory disease |
| US11957746B2 (en) * | 2018-03-26 | 2024-04-16 | Boehringer Ingelheim Animal Health USA Inc. | Method of producing an immunogenic composition |
| CN109316603A (zh) * | 2018-10-31 | 2019-02-12 | 南京大爻网络科技有限公司 | 一种猪支原体肺炎活疫苗耐热冷冻保护剂、制备方法及应用 |
| JP2022520443A (ja) * | 2019-02-15 | 2022-03-30 | セラム インスティチュート オブ インディア プライベイト リミテッド | 弱毒生インフルエンザワクチン組成物及びその調製プロセス |
| EP4013436A1 (en) * | 2019-08-14 | 2022-06-22 | Leukocare Ag | Method for obtaining efficient compositions comprising viral vectors for vaccination or gene therapy |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| AU2021311726A1 (en) * | 2020-07-24 | 2023-02-09 | Boehringer Ingelheim Animal Health USA Inc. | Combination porcine vaccine |
| CN113559256B (zh) * | 2021-08-09 | 2024-03-29 | 广州科力生物科技有限公司 | 一种诺卡氏菌免疫增强剂及其在制备猪用疫苗中的应用 |
| EP4419205A1 (en) * | 2021-10-20 | 2024-08-28 | Solventum Intellectual Properties Company | Phosphate and arginine containing compositions and the delivery of such compositions for virulence suppression |
| CN114891121B (zh) * | 2022-05-11 | 2024-01-19 | 天康制药股份有限公司 | 一种抗pedv和prv的二联病毒样颗粒疫苗及其制备方法 |
| CN114931648B (zh) * | 2022-06-15 | 2024-02-27 | 金宇保灵生物药品有限公司 | 一种猪流行性腹泻和猪传染性胃肠炎二联活疫苗耐热保护剂及其制备方法和应用 |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3155589A (en) | 1958-04-14 | 1964-11-03 | Upjohn Co | Parenteral extravascular injectable vaccines for simultaneous immunization of canidae against rabies, canine distemper, and infectious canine hepatitis |
| US3526696A (en) | 1968-02-14 | 1970-09-01 | Lilly Co Eli | Shipping fever vaccine |
| GB1575155A (en) | 1978-04-11 | 1980-09-17 | Merck & Co Inc | Vaccine stabilizer |
| PT71926B (en) * | 1979-10-29 | 1982-03-31 | Merck & Co Inc | Process for preparing a liquid vaccine comprising a stabilizer |
| US4337242A (en) | 1980-02-05 | 1982-06-29 | Merck & Co., Inc. | Vaccine stabilizer containing L-glutamic acid and L-arginine |
| JPS589688A (ja) | 1981-07-06 | 1983-01-20 | Toyobo Co Ltd | 安定な酵素組成物 |
| JPS6153227A (ja) | 1984-08-23 | 1986-03-17 | Biseibutsu Kagaku Kenkyusho:Kk | 日本脳炎・豚パルボウイルス感染症混合生ワクチン |
| US4867975A (en) | 1988-01-27 | 1989-09-19 | University Of Delaware | Live attenuated temperature-sensitive avian infectious bronchitis virus vaccines and preparation and use thereof |
| AU2088992A (en) | 1992-05-05 | 1993-11-11 | Research Foundation For Microbial Diseases Of Osaka University, The | Stabilized live vaccine |
| US5443959A (en) | 1992-09-09 | 1995-08-22 | Tokuyama Corporation | Method of assaying fibrinogen, dry reagent therefor, and process for the preparation thereof |
| EP0650734B1 (en) | 1993-10-28 | 1999-03-10 | Division Of Microbiology, Kyoto Biken Laboratories, Inc. | Pentavalent live viral vaccine |
| FR2719479B1 (fr) | 1994-05-04 | 1996-07-26 | Sanofi Elf | Formulation stable lyophilisée comprenant une protéine: kit de dosage. |
| US5565318A (en) | 1994-09-02 | 1996-10-15 | Pharmacia Biotech, Inc. | Room temperature stable reagent semi-spheres |
| US5593824A (en) | 1994-09-02 | 1997-01-14 | Pharmacia Biotech, Inc. | Biological reagent spheres |
| FR2742756B1 (fr) | 1995-12-22 | 1998-04-03 | Pasteur Merieux Serums Vacc | Stabilisants pour vaccins vivants, vaccins les contenant et procedes pour leur preparation |
| US5932223A (en) | 1996-09-26 | 1999-08-03 | Merck & Co., Inc. | Rotavirus vaccine formulations |
| WO1999015670A1 (en) | 1997-09-25 | 1999-04-01 | Biotechnology Research And Development Corporation | LKTA DELETION MUTANT OF $i(P. HAEMOLYTICA) |
| CN1053590C (zh) | 1998-10-19 | 2000-06-21 | 卫生部长春生物制品研究所 | 冻干甲型肝炎减毒活疫苗及其保护剂 |
| WO2002011753A1 (fr) | 2000-08-04 | 2002-02-14 | Chugai Seiyaku Kabushiki Kaisha | Preparations proteiniques a injecter |
| EP2591771A1 (en) | 2002-04-11 | 2013-05-15 | MedImmune, LLC | Preservation of bioactive materials by freeze dried foam |
| NZ538394A (en) | 2002-08-26 | 2008-06-30 | Pfizer Prod Inc | Vaccine for respiratory and reproductive system infections in cattles |
| US6931888B2 (en) | 2003-02-07 | 2005-08-23 | Ferro Corporation | Lyophilization method and apparatus for producing particles |
| KR101251902B1 (ko) * | 2003-02-25 | 2013-04-08 | 메디뮨 엘엘씨 | 인플루엔자 백신 조성물의 제조 방법 |
| ATE347373T1 (de) | 2003-07-02 | 2006-12-15 | Biotechnology Res & Dev | Akapsuläre i p. multocida hyae /i deletionsmutanten |
| WO2005052116A2 (en) | 2003-11-19 | 2005-06-09 | Merck & Co., Inc. | Preservative-containing virus formulations |
| ES2619936T3 (es) * | 2004-11-05 | 2017-06-27 | Wellstat Biologics Corporation | Formulaciones de virus envueltos estables y filtrables |
| GB0503337D0 (en) | 2005-02-17 | 2005-03-23 | Glaxosmithkline Biolog Sa | Compositions |
| US7959929B2 (en) | 2005-04-21 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| EP1896610A2 (en) | 2005-05-03 | 2008-03-12 | Handylab, Inc. | Lyophilized pellets |
| WO2007035455A2 (en) | 2005-09-16 | 2007-03-29 | Merial Limited | Stabilizers for freeze-dried vaccines |
| JP5138601B2 (ja) | 2005-11-21 | 2013-02-06 | サノフィ パストゥール リミテッド | 組換えウイルス安定化製剤 |
| EP2004144A1 (en) | 2005-12-02 | 2008-12-24 | Stichting Katholieke Universiteit | Method for obtaining hollow particles |
| CN104758253A (zh) | 2006-01-24 | 2015-07-08 | 安迅生物制药公司 | 大分子微球的制备技术 |
| ATE512660T1 (de) | 2007-03-05 | 2011-07-15 | Cadila Healthcare Ltd | Zusammensetzungen mit peg-interferon-alpha- konjugaten und raffinose als kryoschutzmittel |
| KR102134980B1 (ko) | 2007-04-06 | 2020-07-16 | 다케다 백신즈 인코포레이티드 | 살아있는 약독화된 바이러스를 위한 방법 및 조성물 |
| JP5307801B2 (ja) | 2007-05-18 | 2013-10-02 | メディミューン・エルエルシー | 凍結乾燥フォームによる生物活性材料の防腐 |
| RU2519210C2 (ru) | 2007-06-14 | 2014-06-10 | Дзе Борд Оф Риджентс Фор Оклахома Стейт Юниверсити | Вакцины, содержащие генетические варианты парвовируса собак |
| TWI436789B (zh) | 2008-01-21 | 2014-05-11 | Intervet Int Bv | 含有藥學化合物的顆粒之冷凍乾燥方法及含有此顆粒的藥學包 |
| MX2010008799A (es) | 2008-03-05 | 2010-09-07 | Sanofi Pasteur | Proceso para estabilizar una composicion de vacuna que contiene adyuvante. |
| EP2143440A1 (fr) | 2008-07-09 | 2010-01-13 | Sanofi Pasteur | Agent stabilisant et composition vaccinale comprenant un ou plusieurs flavivirus vivants atténués |
| US7998488B2 (en) | 2008-11-14 | 2011-08-16 | Baxter International Inc. | Vaccine formulations and uses thereof |
| DK2350271T3 (en) | 2008-11-20 | 2016-04-04 | Biogen Ma Inc | ARGININ INACTIVATION OF ENVIRONMENT VIRA |
| CN102459578A (zh) | 2009-01-30 | 2012-05-16 | 俄克拉荷马州大学评议会 | 基于在北美狗中循环的犬瘟热病毒的免疫原性组合物、疫苗和诊断方法 |
| TWI471127B (zh) | 2009-04-29 | 2015-02-01 | Intervet Int Bv | 供人類使用之口服崩解錠劑的製備方法、所製得之口服崩解錠劑、以及含有該口服崩解錠劑的包裝物 |
| TWI468157B (zh) | 2009-04-29 | 2015-01-11 | Intervet Int Bv | 形成錠劑的方法，進行該方法的系統及包含該錠劑的包裝物 |
| US8557253B2 (en) | 2009-10-07 | 2013-10-15 | Sanofi Pasteur Sa | Stabilizing excipient for inactivated whole virus vaccine |
| EP2509634B1 (en) | 2009-12-11 | 2019-03-06 | Pfizer Inc | Stable formulations for lyophilizing therapeutic particles |
| MY161198A (en) * | 2011-02-17 | 2017-04-14 | Boehringer Ingelheim Vetmedica Gmbh | Novel european prrsv strain |
| US20140017318A1 (en) | 2012-07-10 | 2014-01-16 | Kevin O'Connell | Method to produce a medicinal product comprising a biologically active protein and the resulting product |
| US9314519B2 (en) | 2012-08-21 | 2016-04-19 | Intervet Inc. | Liquid stable virus vaccines |
| US9480739B2 (en) | 2013-03-15 | 2016-11-01 | Intervet Inc. | Bovine virus vaccines that are liquid stable |
| US9393298B2 (en) | 2013-03-15 | 2016-07-19 | Intervet Inc. | Liquid stable bovine virus vaccines |
| AR097762A1 (es) | 2013-09-27 | 2016-04-13 | Intervet Int Bv | Formulaciones secas de vacunas que son estables a temperatura ambiente |
| AR099470A1 (es) | 2014-02-17 | 2016-07-27 | Intervet Int Bv | Vacunas de virus de aves de corral líquidas |
| TWI670085B (zh) | 2014-02-19 | 2019-09-01 | 荷蘭商英特威國際公司 | 液體穩定之豬病毒疫苗 |
-
2015
- 2015-02-17 TW TW104105735A patent/TWI670085B/zh active
- 2015-02-18 ES ES15704809T patent/ES2793942T3/es active Active
- 2015-02-18 WO PCT/EP2015/053364 patent/WO2015124594A1/en active Application Filing
- 2015-02-18 EP EP15704809.1A patent/EP3107572B1/en active Active
- 2015-02-18 CN CN201580009514.6A patent/CN106061503B/zh active Active
- 2015-02-18 RU RU2016137121A patent/RU2695523C2/ru active
- 2015-02-18 JP JP2016552582A patent/JP6596008B2/ja active Active
- 2015-02-18 US US15/119,152 patent/US9855336B2/en active Active
- 2015-02-18 BR BR112016018871-3A patent/BR112016018871B1/pt active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015124594A1 (en) | 2015-08-27 |
| EP3107572B1 (en) | 2020-04-22 |
| JP6596008B2 (ja) | 2019-10-23 |
| JP2017506643A (ja) | 2017-03-09 |
| BR112016018871B1 (pt) | 2024-02-27 |
| TW201613556A (en) | 2016-04-16 |
| CN106061503B (zh) | 2020-06-16 |
| US20170014513A1 (en) | 2017-01-19 |
| RU2016137121A3 (ru) | 2018-10-03 |
| BR112016018871A2 (ru) | 2017-08-15 |
| CN106061503A (zh) | 2016-10-26 |
| EP3107572A1 (en) | 2016-12-28 |
| RU2695523C2 (ru) | 2019-07-23 |
| US9855336B2 (en) | 2018-01-02 |
| TWI670085B (zh) | 2019-09-01 |
| ES2793942T3 (es) | 2020-11-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2016137121A (ru) | Вакцины против вирусов свиней, стабильные в жидкой форме | |
| RU2015143465A (ru) | Жидкие стабильные вакцины, содержащие вирус крупного рогатого скота | |
| AR117530A2 (es) | Una composición que comprende un virus del síndrome reproductor y respiratorio porcino (prrsv) de un tipo europeo, un producto de vacuna, una composición de proteína, un ácido nucleico aislado y un vector de expresión recombinante | |
| HRP20181102T1 (hr) | Cjepiva za hsv-2 | |
| AR099470A1 (es) | Vacunas de virus de aves de corral líquidas | |
| JP2016531854A5 (ru) | ||
| RU2015109724A (ru) | Жидкие стабильные вирусные вакцины | |
| EP4104854A3 (en) | Multivalent vaccines for rabies virus and coronaviruses | |
| IL276210B2 (en) | MERS-COV vaccine | |
| RU2010112939A (ru) | Снижение сопутствующих инфекций у свиней с помощью антигена pcv2 | |
| PH12017501370A1 (en) | Bivalent swine influenza virus vaccine | |
| EA201892735A1 (ru) | Состав вакцины против hiv | |
| RU2016110430A (ru) | Pcv2b дивергентная вакцинная композиция и способы её применения | |
| CO6210756A2 (es) | La proteina linfopoyetina estromal timica canina y usos de la misma | |
| MX2018010958A (es) | Vacuna para virus de zika atenuado vivo. | |
| EA201491123A1 (ru) | Субъединичная вакцина против цирковируса свиней типа 2 (pcv2) | |
| WO2014150822A3 (en) | Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use | |
| RU2014127714A (ru) | ВАКЦИНА НА ОСНОВЕ ТОКСИНОВ Clostridium difficile | |
| MX2020012913A (es) | Proteinas de consenso para el virus de la enfermedad de la fiebre aftosa (fmdv), secuencias de codificacion para estas y vacunas elaboradas a partir de estas. | |
| RU2018127403A (ru) | Поливалентная вакцина против hyo и ее применение | |
| EA201690115A1 (ru) | Комбинированные иммуногенные композиции | |
| RU2015106916A (ru) | Полипептиды clostridium difficile в виде вакцины | |
| HRP20191864T1 (hr) | Imunogeni pripravci protiv bakterije clostridium difficile | |
| EA202191145A1 (ru) | Вакцина виб 4/91 с гетерологичным шиповидным белком | |
| MX2021011913A (es) | Composiciones de virus inactivado y formulaciones de vacunas contra el zika. |