BRPI9905902B8 - "molécula polinucleotídica isolada, plasmídeo, e método para produzir um vírus prrs norte-americano" - Google Patents

"molécula polinucleotídica isolada, plasmídeo, e método para produzir um vírus prrs norte-americano"

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Publication number
BRPI9905902B8
BRPI9905902B8 BRPI9905902A BR9905902A BRPI9905902B8 BR PI9905902 B8 BRPI9905902 B8 BR PI9905902B8 BR PI9905902 A BRPI9905902 A BR PI9905902A BR 9905902 A BR9905902 A BR 9905902A BR PI9905902 B8 BRPI9905902 B8 BR PI9905902B8
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Prior art keywords
north american
viral vectors
american prrs
isolated polynucleotide
virus
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BRPI9905902A
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English (en)
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BRPI9905902B1 (pt
BR9905902A (pt
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Gregory Calvert Jay
George Sheppard Michael
Wan Welch Siao-Kun
Original Assignee
Pah Usa 15 Llc
Pfizer Prod Inc
Zoetis P Llc
Zoetis Services Llc
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Application filed by Pah Usa 15 Llc, Pfizer Prod Inc, Zoetis P Llc, Zoetis Services Llc filed Critical Pah Usa 15 Llc
Publication of BR9905902A publication Critical patent/BR9905902A/pt
Publication of BRPI9905902B1 publication Critical patent/BRPI9905902B1/pt
Publication of BRPI9905902B8 publication Critical patent/BRPI9905902B8/pt

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Abstract

patente de invenção: <b>"clone de cdna infeccioso do vírus da síndrome reprodutiva e respiratória de porcino norte-americana (prrs) e seus usos"<d>. a invenção proporciona moléculas polinucleotídicas isoladas, incluindo plasmídeos; vetores virais; e células hospedeiras transfectadas que compreendem uma seqüência de dna codificador de uma seqüência de rna, infecciosa codificadora de um vírus prrs norte-americano; e também vírus prrs norte-americanos por elas codificados. a invenção proporciona ainda moléculas de rna infecciosas isoladas codificadoras de um vírus prrs norte-americano. a invenção também proporciona moléculas polinucleotídicas isoladas, moléculas de rna infecciosas, vetores virais células hospedeiras transfectadas codificadoras de vírus prrs norte-americanos genéticamente modificados; e vírus prrs norte-americanos genéticamente modificados por elas codificados. a invenção também proporciona vacinas compreendendo tais plasmídeos, moléculas de rna, vetores virais e vírus prrs norte-americanos e métodos de utilização destas vacinas em suínos e noutros animais. também são proporcionadas moléculas polinucleotídicas isolada, vetores virais e células hospedeiras transfectadas que compreendem uma seqüência nucleotídica codificadora de um peptídeo de um vírus prrs norte-americano. estes vetores virais e linhas celulares hospedeiras transfectadas são úteis na produção de peptídeos para compensar as seqüências codificadoras de peptídeos mutagenizados codificadas pelos vírus prrs norte-americano genéticamente modificados de forma a poderem ser produzidos viriões funcionais.
BRPI9905902A 1998-12-22 1999-12-17 "molécula polinucleotídica isolada, plasmídeo, e método para produzir um vírus prrs norte-americano" BRPI9905902B8 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11334598P 1998-12-22 1998-12-22

Publications (3)

Publication Number Publication Date
BR9905902A BR9905902A (pt) 2000-12-12
BRPI9905902B1 BRPI9905902B1 (pt) 2015-09-01
BRPI9905902B8 true BRPI9905902B8 (pt) 2021-05-25

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US (2) US6500662B1 (pt)
EP (2) EP1627919B1 (pt)
JP (7) JP4113642B2 (pt)
CN (1) CN1171996C (pt)
AR (2) AR025146A1 (pt)
AT (1) ATE309364T1 (pt)
AU (1) AU769841B2 (pt)
BR (1) BRPI9905902B8 (pt)
CA (2) CA2440933A1 (pt)
CY (2) CY1105680T1 (pt)
DE (1) DE69928209T9 (pt)
DK (2) DK1627919T3 (pt)
ES (2) ES2251162T3 (pt)
HK (1) HK1029140A1 (pt)
MX (1) MXPA03009354A (pt)
NZ (2) NZ501264A (pt)
PT (1) PT1627919E (pt)
ZA (1) ZA997289B (pt)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0839912A1 (en) * 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
US20040224327A1 (en) * 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
WO2000053787A1 (en) 1999-03-08 2000-09-14 Id-Lelystad, Instituut Voor Dierhouderij En Dierg Ezondheid B.V. Prrsv vaccines
US7691389B2 (en) * 1998-12-22 2010-04-06 Pfizer Inc Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7618797B2 (en) * 1998-12-22 2009-11-17 Pfizer Inc Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
DK1183332T3 (da) 1999-04-22 2010-09-06 Us Agriculture Porcint Reproduktions- og Respirations Syndrom-vaccine baseret på isolere JA-142
WO2002038753A1 (fr) * 2000-11-09 2002-05-16 Junichi Watanabe Procede de criblage d'un gene agissant sur les conditions pathologiques ou la survie d'un animal infecte par un pathogene
US6841364B2 (en) * 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
US7906311B2 (en) * 2002-03-20 2011-03-15 Merial Limited Cotton rat lung cells for virus culture
WO2005009462A2 (en) * 2003-07-24 2005-02-03 Merial Limited Vaccine formulations comprising an oil-in-water emulsion
BRPI0510928A (pt) 2004-06-18 2007-11-13 Univ Minnesota identificação de organismos viralmente infectados e vacinados
KR100872840B1 (ko) 2004-07-09 2008-12-22 (주)씨아이디 돼지생식기호흡기증후군 바이러스에 대한 전체-길이의감염성이 있는 cDNA 클론 및 이의 용도
US7632636B2 (en) 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
RU2007117510A (ru) * 2004-11-11 2008-11-20 Пфайзер Продактс Инк. (Us) Мутантный вирус репродуктивного и респираторного синдрома свиней
ATE462445T1 (de) 2005-01-13 2010-04-15 Boehringer Ingelheim Vetmed Prrs-impfstoffe
MX2007009060A (es) * 2005-02-25 2007-09-11 Pfizer Prod Inc Mutantes de la proteina n del virus del sindrome reproductor y respiratorio de los porcinos.
UA95778C2 (ru) 2005-06-24 2011-09-12 Риджентс Оф Зе Юниверсити Оф Миннесота Вирусы репродуктивно-респираторного синдрома свиней, их инфекционные клоны и мутанты и способы применения
US7608272B2 (en) * 2005-08-30 2009-10-27 Board Of Regents Of The University Of Nebraska Methods and compositions for vaccination of animals with PRRSV antigens with improved immunogenicity
US8202717B2 (en) 2007-01-12 2012-06-19 The Board Of Trustees Of The University Of Illinois Non-simian cells for growth of porcine reproductive and respiratory syndrome (PRRS) virus
US7666585B2 (en) 2007-06-15 2010-02-23 Protatek International, Inc. Construction of chimera PRRSV, compositions and vaccine preparations
CN101848995A (zh) * 2007-06-25 2010-09-29 南达科他州立大学 重组的北美1型猪繁殖与呼吸综合征病毒及使用方法
UA106475C2 (uk) * 2008-08-25 2014-09-10 Берингер Ингельхайм Ветмедика, Инк. Спосіб вакцинації свині проти високопатогенного репродуктивно-респіраторного синдрому свиней (hp prrs)
US8012735B2 (en) * 2009-03-02 2011-09-06 University Of Kentucky Research Foundation Infectious cDNA clone of the modified live virus vaccine strain of Equine arteritis virus
TWI627281B (zh) 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物
SI2475384T1 (sl) * 2009-09-10 2016-12-30 Merial, Inc. Nove formulacije cepiva, ki obsegajo adjuvante, vsebujoče saponin
UA108902C2 (uk) * 2010-11-10 2015-06-25 Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування
MY186535A (en) 2011-02-17 2021-07-26 Boehringer Ingelheim Vetmedica Gmbh Novel european prrsv strain
WO2012110490A1 (en) 2011-02-17 2012-08-23 Boehringer Ingelheim Vetmedica Gmbh Commercial scale process for production of prrsv
US9315781B2 (en) 2011-07-29 2016-04-19 Boehringer Ingelheim Vetmedica Gmbh Infectious CDNA clone of european PRRS virus and uses thereof
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
UA114503C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv та mycoplasma hyopneumoniae
UA114504C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs
US9120859B2 (en) 2012-04-04 2015-09-01 Zoetis Services Llc Mycoplasma hyopneumoniae vaccine
KR102012109B1 (ko) * 2012-05-17 2019-08-19 조에티스 엘엘씨 이유 전 돼지 생식기 호흡기 증후군(prrs) 바이러스에 대한 효과적인 백신접종
EP2968513A2 (en) 2013-03-15 2016-01-20 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use
BR112016006192A2 (pt) 2013-09-25 2017-09-26 Zoetis Services Llc composição de vacina de divergente de pcv2b e métodos de uso
DK3083947T3 (da) * 2013-12-20 2019-07-08 Boehringer Ingelheim Vetmedica Gmbh Prrs-virusvariant, cdna-klon af europæisk prrs-virus, samt anvendelser deraf
CN104198773A (zh) * 2014-08-29 2014-12-10 苏州市吴中区胥口广博模具加工厂 三轴联动式大型电路板测试夹具的第二转轴组
TWI554609B (zh) * 2014-11-19 2016-10-21 國立屏東科技大學 抗豬生殖與呼吸綜合症病毒感染之重組融合抗原基因、重組融合抗原蛋白及含彼之次單位疫苗組成物
DK3344289T3 (da) 2015-08-31 2020-04-14 Boehringer Ingelheim Vetmedica Gmbh Pestivirusvacciner mod medfødt tremor
WO2017106079A1 (en) 2015-12-14 2017-06-22 Boehringer Ingelheim Vetmedica, Inc. Hybrid core feline vaccines
CA3032891A1 (en) 2016-08-05 2018-02-08 Hipra Scientific, S.L.U. Porcine reproductive and respiratory syndrome virus cdna clone and uses thereof
EP3554537A2 (en) 2016-12-14 2019-10-23 Zoetis Services LLC Effective vaccination against european strains of porcine reproductive and respiratory syndrome (prrs) virus prior to weaning
CN107586780B (zh) * 2017-10-25 2019-10-11 中国农业科学院兰州兽医研究所 一种抑制猪繁殖与呼吸综合征病毒的长链非编码rna
CN109943590B (zh) * 2019-04-18 2022-11-18 西南大学 一种复制缺陷型猪圆环病毒、其制备方法及应用
CN111996174A (zh) * 2020-02-06 2020-11-27 广西大学 猪繁殖与呼吸综合征病毒及其克隆载体和插入基因方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3137631A (en) 1959-12-01 1964-06-16 Faberge Inc Encapsulation in natural products
US3959457A (en) 1970-06-05 1976-05-25 Temple University Microparticulate material and method of making such material
US4015100A (en) 1974-01-07 1977-03-29 Avco Everett Research Laboratory, Inc. Surface modification
JPS5186117A (en) 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4205060A (en) 1978-12-20 1980-05-27 Pennwalt Corporation Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use
US4452747A (en) 1982-03-22 1984-06-05 Klaus Gersonde Method of and arrangement for producing lipid vesicles
US4744933A (en) 1984-02-15 1988-05-17 Massachusetts Institute Of Technology Process for encapsulation and encapsulated active material system
US5008050A (en) 1984-06-20 1991-04-16 The Liposome Company, Inc. Extrusion technique for producing unilamellar vesicles
US4921706A (en) 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US4606940A (en) 1984-12-21 1986-08-19 The Ohio State University Research Foundation Small particle formation and encapsulation
US5009956A (en) 1987-02-24 1991-04-23 Univ Minnesota Phospholipase A2-resistant liposomes
IT8819772A0 (it) * 1988-03-15 1988-03-15 Honeywell Bull Spa Dispositivo selettivo a terra per apparecchiature elettroniche.
US4927637A (en) 1989-01-17 1990-05-22 Liposome Technology, Inc. Liposome extrusion method
US4944948A (en) 1989-02-24 1990-07-31 Liposome Technology, Inc. EGF/Liposome gel composition and method
US5132117A (en) 1990-01-11 1992-07-21 Temple University Aqueous core microcapsules and method for their preparation
EP0587780B2 (en) 1991-06-06 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
US6042830A (en) 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
US5846805A (en) 1991-08-26 1998-12-08 Boehringer Ingelheim Animal Health, Inc. Culture of swine infertility and respiratory syndrome virus in simian cells
WO1993003760A1 (en) 1991-08-26 1993-03-04 James Edward Collins Sirs vaccine and diagnosis method
CA2076744C (en) 1991-08-26 2000-06-27 Danny W. Chladek Viral agent associated with mystery swine disease
AU2696792A (en) 1991-09-16 1993-04-27 David A Benfield Vaccine for mystery swine disease and method for diagnosis thereof
FR2686097B1 (fr) 1992-01-14 1994-12-30 Rhone Merieux Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie.
US5203054A (en) 1992-09-28 1993-04-20 Emhart Inc. Retainer for trunk lid torsion bars
US5695766A (en) 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
US6251397B1 (en) * 1992-10-30 2001-06-26 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same
US6773908B1 (en) * 1992-10-30 2004-08-10 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US6592873B1 (en) 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
ES2152304T3 (es) 1993-02-08 2001-02-01 Bayer Ag Procedimiento para el crecimiento del virus del sindrome reproductivo y respiratorio porcino y su uso en vacunas.
ES2074950B1 (es) 1993-09-17 1996-03-16 Iberica Cyanamid Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda.
DE69530227T2 (de) 1994-04-15 2004-04-01 Temple University Methode zum einkapseln mittels eines wässrigen lösungsmittels und mikrokapseln
DE69535061T2 (de) * 1994-08-05 2007-01-25 Regents Of The University Of Minnesota, Minneapolis Virale nukleotidsequenz vr-2332 und nutzungsverfahren
PT732340E (pt) 1995-03-14 2004-09-30 Akzo Nobel Nv Expressao de polipeptidos do virus da sindrome reprodutiva e respiratoria porcina na mesma celula
SK119498A3 (en) 1996-03-01 1999-07-12 Schering Corp Porcine reproductive and respiratory syndrome vaccine
EP0839912A1 (en) 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
WO1998055626A2 (en) 1997-06-05 1998-12-10 Origen, Inc. Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine
US6288199B1 (en) * 1999-11-02 2001-09-11 Ppg Industries Ohio, Inc. Blocked isocyanate-based compounds and compositions containing the same

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