AR025146A1 - UNA MOLÉCULA AISLADA DE POLINUCLEoTIDO QUE COMPRENDE UNA SECUENCIA DE ADN QUE CODIFICA UN VIRUS PRRS NORTEAMERICANO, CÉLULA HUESPED, PLÁSMIDO, MÉTODO PARA GENERAR UN VIRUS PRRS NORTEAMERICANO Y VACUNA. - Google Patents

UNA MOLÉCULA AISLADA DE POLINUCLEoTIDO QUE COMPRENDE UNA SECUENCIA DE ADN QUE CODIFICA UN VIRUS PRRS NORTEAMERICANO, CÉLULA HUESPED, PLÁSMIDO, MÉTODO PARA GENERAR UN VIRUS PRRS NORTEAMERICANO Y VACUNA.

Info

Publication number
AR025146A1
AR025146A1 ARP990106325A AR025146A1 AR 025146 A1 AR025146 A1 AR 025146A1 AR P990106325 A ARP990106325 A AR P990106325A AR 025146 A1 AR025146 A1 AR 025146A1
Authority
AR
Argentina
Prior art keywords
north american
american prrs
isolated
prrs virus
viral vectors
Prior art date
Application number
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR025146A1 publication Critical patent/AR025146A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2770/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10061—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10061—Methods of inactivation or attenuation
    • C12N2770/10062—Methods of inactivation or attenuation by genetic engineering

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Pregnancy & Childbirth (AREA)

Abstract

Se describe una molécula aislada de polinucleotidos inclusive plásmidos; vectores víricos; y células hospedantes transfectadas que comprenden una secuenciade ADN que codifica una secuencia infecciosa de ARN que a su vez codifica un virus de PRRSnort eamericano; y también los virus del PRRS norteamericano,codificados de este modo. Además se proporcionan moléculas infecciosas aisladas de ARN que codifica un virus del PRRS norteamericano. Se describen tambiénmoléculas aisladas depolinucleotidos, m oléculas infecciosas de ARN, vectores víricos, y células hospedantes transfectadas que codifican los virus del PRRSnorteamericano, modificados genéticamente ; y los virus del PRRS norteamericano, modificados genéticamente,codificados de este modo. S e describen tambiénvacunas que comprenden dichos plásmidos, dichas moléculas de ARN, dichos vectores víricos y dichos virus del PRRS norteamericano, y métodos de usar estasvacunas en cerdos y en otros animales. También seproporcionan moléculas aisla das de polinucleotidos, vectores víricos, y células hospedantes transfectadas quecomprenden una secuencia de nucleotidos, que codifica un péptido de un virus del PRRS norteamericano. Estos vectores víricos y estas líneasde célulashospedantes transfe ctadas son utiles para proporcionar péptidos con el fin de compensar secuencias de codificacion de péptidos mutados de secuencias de ADN quecodifican virus del PRRS norteamericano modificados genéticamente de manera talque se pueden generar viriones funcionales.
ARP990106325 1998-12-22 1999-12-13 UNA MOLÉCULA AISLADA DE POLINUCLEoTIDO QUE COMPRENDE UNA SECUENCIA DE ADN QUE CODIFICA UN VIRUS PRRS NORTEAMERICANO, CÉLULA HUESPED, PLÁSMIDO, MÉTODO PARA GENERAR UN VIRUS PRRS NORTEAMERICANO Y VACUNA. AR025146A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11334598P 1998-12-22 1998-12-22

Publications (1)

Publication Number Publication Date
AR025146A1 true AR025146A1 (es) 2002-11-13

Family

ID=22348908

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP990106325 AR025146A1 (es) 1998-12-22 1999-12-13 UNA MOLÉCULA AISLADA DE POLINUCLEoTIDO QUE COMPRENDE UNA SECUENCIA DE ADN QUE CODIFICA UN VIRUS PRRS NORTEAMERICANO, CÉLULA HUESPED, PLÁSMIDO, MÉTODO PARA GENERAR UN VIRUS PRRS NORTEAMERICANO Y VACUNA.
ARP070101362 AR058249A2 (es) 1998-12-22 2007-03-30 Una molecula aislada de polinucleotido que comprende una secuencia de adn que codifica una molecula infecciosa de arn que codifica un virus prrs norteamericano, celula transfectada y vacuna

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP070101362 AR058249A2 (es) 1998-12-22 2007-03-30 Una molecula aislada de polinucleotido que comprende una secuencia de adn que codifica una molecula infecciosa de arn que codifica un virus prrs norteamericano, celula transfectada y vacuna

Country Status (18)

Country Link
US (2) US6500662B1 (es)
EP (2) EP1018557B9 (es)
JP (7) JP4113642B2 (es)
CN (1) CN1171996C (es)
AR (2) AR025146A1 (es)
AT (1) ATE309364T1 (es)
AU (1) AU769841B2 (es)
BR (1) BRPI9905902B8 (es)
CA (2) CA2440933A1 (es)
CY (2) CY1105680T1 (es)
DE (1) DE69928209T9 (es)
DK (2) DK1018557T5 (es)
ES (2) ES2459568T3 (es)
HK (1) HK1029140A1 (es)
MX (1) MXPA03009354A (es)
NZ (2) NZ513289A (es)
PT (1) PT1627919E (es)
ZA (1) ZA997289B (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224327A1 (en) * 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
EP0839912A1 (en) * 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
US7691389B2 (en) * 1998-12-22 2010-04-06 Pfizer Inc Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7618797B2 (en) * 1998-12-22 2009-11-17 Pfizer Inc Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
JP3961222B2 (ja) 1999-03-08 2007-08-22 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー Ｐｒｒｓｖワクチン
DK1183332T3 (da) 1999-04-22 2010-09-06 Us Agriculture Porcint Reproduktions- og Respirations Syndrom-vaccine baseret på isolere JA-142
JPWO2002038753A1 (ja) * 2000-11-09 2004-03-18 渡辺　純一 病原体に感染した動物の病態または生存に影響を与える遺伝子のスクリーニング方法
US6841364B2 (en) * 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
US7906311B2 (en) 2002-03-20 2011-03-15 Merial Limited Cotton rat lung cells for virus culture
US7371395B2 (en) * 2003-07-24 2008-05-13 Merial Limited Vaccine formulations
KR20070028547A (ko) 2004-06-18 2007-03-12 리전츠 오브 더 유니버스티 오브 미네소타 바이러스에 감염되고 백신접종된 생물의 동정
KR100872840B1 (ko) 2004-07-09 2008-12-22 (주)씨아이디 돼지생식기호흡기증후군 바이러스에 대한 전체-길이의감염성이 있는 cDNA 클론 및 이의 용도
US7632636B2 (en) * 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
KR20070064666A (ko) * 2004-11-11 2007-06-21 화이자 프로덕츠 인코포레이티드 돼지의 생식 및 호흡 증후군 바이러스 돌연변이
EP1838343B1 (en) 2005-01-13 2010-03-31 Boehringer Ingelheim Vetmedica Gmbh Prrs vaccines
KR20100090311A (ko) * 2005-02-25 2010-08-13 화이자 프로덕츠 인크. 돼지 생식기 호흡기 증후군 바이러스의 ｎ 단백질 돌연변이체
CA2611820C (en) 2005-06-24 2015-10-06 Regents Of The University Of Minnesota Prrs viruses, infectious clones, mutants thereof, and methods of use
BRPI0615610A2 (pt) * 2005-08-30 2011-05-24 Univ Nebraska processos e composições para vacinação de animais com antìgenos de prrsv com maior imunogenicidade
MX2009007457A (es) 2007-01-12 2009-08-12 Univ Illinois Celulas que no son de mono para el desarrollo del virus del sindrome porcino reproductor y respiratorio (prrs).
US7666585B2 (en) 2007-06-15 2010-02-23 Protatek International, Inc. Construction of chimera PRRSV, compositions and vaccine preparations
ES2389748T3 (es) * 2007-06-25 2012-10-31 South Dakota State University Virus del síndrome reproductivo y respiratorio porcino de tipo 1 norteamericano recombinante y métodos de uso
CN102316895A (zh) * 2008-08-25 2012-01-11 贝林格尔.英格海姆维特梅迪卡有限公司 抗高致病性猪生殖与呼吸综合征(hp prrs)的疫苗
US8012735B2 (en) * 2009-03-02 2011-09-06 University Of Kentucky Research Foundation Infectious cDNA clone of the modified live virus vaccine strain of Equine arteritis virus
AR078253A1 (es) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
PL2475384T3 (pl) * 2009-09-10 2017-02-28 Merial, Inc. Nowe formulacje szczepionek obejmujące adiuwanty zawierające saponiny
UA108902C2 (uk) * 2010-11-10 2015-06-25 Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування
SG192821A1 (en) 2011-02-17 2013-09-30 Boehringer Ingelheim Vetmed Commercial scale process for production of prrsv
WO2012110489A2 (en) 2011-02-17 2012-08-23 Boehringer Ingelheim Vetmedica Gmbh Novel european prrsv strain
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
US9315781B2 (en) 2011-07-29 2016-04-19 Boehringer Ingelheim Vetmedica Gmbh Infectious CDNA clone of european PRRS virus and uses thereof
UA114503C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv та mycoplasma hyopneumoniae
US9120859B2 (en) 2012-04-04 2015-09-01 Zoetis Services Llc Mycoplasma hyopneumoniae vaccine
UA114504C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs
MX2014013964A (es) 2012-05-17 2015-03-04 Zoetis Llc Vacunacion eficaz contral el virus del sindrome reproductivo y respiratorio porcino (prrs) antes del destete.
US9579373B2 (en) 2013-03-15 2017-02-28 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use
KR102319843B1 (ko) 2013-09-25 2021-10-29 조에티스 서비시즈 엘엘씨 Pcv2b 분지형 백신 조성물 및 사용 방법
CA2930042C (en) * 2013-12-20 2022-06-21 Boehringer Ingelheim Vetmedica Gmbh Prrs virus variant, european prrs virus cdna clone, and uses thereof
CN104198773A (zh) * 2014-08-29 2014-12-10 苏州市吴中区胥口广博模具加工厂 三轴联动式大型电路板测试夹具的第二转轴组
TWI554609B (zh) 2014-11-19 2016-10-21 國立屏東科技大學 抗豬生殖與呼吸綜合症病毒感染之重組融合抗原基因、重組融合抗原蛋白及含彼之次單位疫苗組成物
PL3344289T3 (pl) 2015-08-31 2021-01-11 Boehringer Ingelheim Vetmedica Gmbh Szczepionki Pestiwirusowe na drżenia wrodzone
US10188725B2 (en) 2015-12-14 2019-01-29 Elanco Us Inc. Hybrid core feline vaccines
WO2018024677A1 (en) 2016-08-05 2018-02-08 Hipra Scientific, S.L.U. PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS cDNA CLONE AND USES THEREOF
JP7129978B2 (ja) 2016-12-14 2022-09-02 ゾエティス・サービシーズ・エルエルシー 豚繁殖・呼吸障害症候群（ｐｒｒｓ）ウイルスの欧州株に対抗する離乳前の効果的なワクチン接種
CN107586780B (zh) * 2017-10-25 2019-10-11 中国农业科学院兰州兽医研究所 一种抑制猪繁殖与呼吸综合征病毒的长链非编码rna
CN109943590B (zh) * 2019-04-18 2022-11-18 西南大学 一种复制缺陷型猪圆环病毒、其制备方法及应用
CN111996174A (zh) * 2020-02-06 2020-11-27 广西大学 猪繁殖与呼吸综合征病毒及其克隆载体和插入基因方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3137631A (en) 1959-12-01 1964-06-16 Faberge Inc Encapsulation in natural products
US3959457A (en) 1970-06-05 1976-05-25 Temple University Microparticulate material and method of making such material
US4015100A (en) 1974-01-07 1977-03-29 Avco Everett Research Laboratory, Inc. Surface modification
JPS5186117A (en) 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4205060A (en) 1978-12-20 1980-05-27 Pennwalt Corporation Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use
US4452747A (en) 1982-03-22 1984-06-05 Klaus Gersonde Method of and arrangement for producing lipid vesicles
US4744933A (en) 1984-02-15 1988-05-17 Massachusetts Institute Of Technology Process for encapsulation and encapsulated active material system
US5008050A (en) 1984-06-20 1991-04-16 The Liposome Company, Inc. Extrusion technique for producing unilamellar vesicles
US4921706A (en) 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US4606940A (en) 1984-12-21 1986-08-19 The Ohio State University Research Foundation Small particle formation and encapsulation
US5009956A (en) 1987-02-24 1991-04-23 Univ Minnesota Phospholipase A2-resistant liposomes
IT8819772A0 (it) * 1988-03-15 1988-03-15 Honeywell Bull Spa Dispositivo selettivo a terra per apparecchiature elettroniche.
US4927637A (en) 1989-01-17 1990-05-22 Liposome Technology, Inc. Liposome extrusion method
US4944948A (en) 1989-02-24 1990-07-31 Liposome Technology, Inc. EGF/Liposome gel composition and method
US5132117A (en) 1990-01-11 1992-07-21 Temple University Aqueous core microcapsules and method for their preparation
ATE118352T1 (de) 1991-06-06 1995-03-15 Stichting Centr Diergeneeskund Erreger der mysteriösen schweinekrankheit,impfstoff-zusammensetzungen und diagnose kits.
US6042830A (en) 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
ATE144144T1 (de) 1991-08-26 1996-11-15 James Edward Collins Vakzine gegen und diagnosemethode für das schweine-unfruchtbarkeits- und atmungs-syndrom (suas)
US5846805A (en) 1991-08-26 1998-12-08 Boehringer Ingelheim Animal Health, Inc. Culture of swine infertility and respiratory syndrome virus in simian cells
MX9204885A (es) 1991-08-26 1994-05-31 Boehringer Animal Health Inc Composicion de vacuna que comprende virus del sindrome de infertilidad y respiratorio de los cerdos.
WO1993006211A1 (en) 1991-09-16 1993-04-01 Collins James E Vaccine for mystery swine disease and method for diagnosis thereof
FR2686097B1 (fr) 1992-01-14 1994-12-30 Rhone Merieux Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie.
US5203054A (en) 1992-09-28 1993-04-20 Emhart Inc. Retainer for trunk lid torsion bars
US6592873B1 (en) 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
US5695766A (en) 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
US6773908B1 (en) * 1992-10-30 2004-08-10 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US6251397B1 (en) * 1992-10-30 2001-06-26 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same
EP0683816B1 (en) 1993-02-08 2000-11-02 Bayer Corporation Process for growing porcine reproductive and respiratory syndrome virus and its use in vaccines
ES2074950B1 (es) 1993-09-17 1996-03-16 Iberica Cyanamid Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda.
AU2386595A (en) 1994-04-15 1995-11-10 Children's Hospital Of Philadelphia, The Aqueous solvent encapsulation method, apparatus and microcapsules
ATE329616T1 (de) * 1994-08-05 2006-07-15 Univ Minnesota Virale nukleotidsequenz vr-2332 und nutzungsverfahren
EP0732340B1 (en) 1995-03-14 2004-06-09 Akzo Nobel N.V. Expression of porcine reproductive respiratory syndrome virus polypeptides in the same cell
BR9708443B1 (pt) 1996-03-01 2012-06-12 vacina contra a sÍndrome reprodutiva e respiratària em porcinos.
EP0839912A1 (en) 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
AU7960598A (en) 1997-06-05 1998-12-21 Origen, Inc. Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine
US6288199B1 (en) * 1999-11-02 2001-09-11 Ppg Industries Ohio, Inc. Blocked isocyanate-based compounds and compositions containing the same

Also Published As

Publication number Publication date
CA2440933A1 (en) 2000-06-22
EP1627919B1 (en) 2014-02-12
JP4159242B2 (ja) 2008-10-01
MXPA03009354A (es) 2004-03-02
DK1627919T3 (en) 2014-03-10
HK1029140A1 (en) 2001-03-23
DE69928209T9 (de) 2006-10-19
CN1171996C (zh) 2004-10-20
CN1263945A (zh) 2000-08-23
CY1105680T1 (el) 2014-07-02
BR9905902A (pt) 2000-12-12
US6500662B1 (en) 2002-12-31
AR058249A2 (es) 2008-01-30
JP2004081218A (ja) 2004-03-18
ES2251162T3 (es) 2006-04-16
JP2008289485A (ja) 2008-12-04
JP2008113670A (ja) 2008-05-22
AU6173399A (en) 2000-06-29
US7232680B2 (en) 2007-06-19
JP2001224384A (ja) 2001-08-21
DE69928209T2 (de) 2006-06-08
JP2008131957A (ja) 2008-06-12
EP1018557B9 (en) 2006-06-28
BRPI9905902B1 (pt) 2015-09-01
EP1627919A1 (en) 2006-02-22
CA2290220C (en) 2013-11-19
DK1018557T3 (da) 2005-12-05
PT1627919E (pt) 2014-05-02
EP1018557A2 (en) 2000-07-12
DK1018557T5 (da) 2006-05-15
ATE309364T1 (de) 2005-11-15
CY1115010T1 (el) 2016-12-14
AU769841B2 (en) 2004-02-05
JP2001218591A (ja) 2001-08-14
CA2290220A1 (en) 2000-06-22
JP4130729B2 (ja) 2008-08-06
JP4335287B2 (ja) 2009-09-30
NZ501264A (en) 2001-09-28
ZA997289B (en) 2001-05-24
JP4113642B2 (ja) 2008-07-09
JP2000189178A (ja) 2000-07-11
DE69928209D1 (de) 2005-12-15
EP1018557A3 (en) 2002-05-02
NZ513289A (en) 2003-04-29
US20020172690A1 (en) 2002-11-21
EP1018557B1 (en) 2005-11-09
ES2459568T3 (es) 2014-05-09
BRPI9905902B8 (pt) 2021-05-25

Similar Documents

Publication Publication Date Title
AR025146A1 (es) UNA MOLÉCULA AISLADA DE POLINUCLEoTIDO QUE COMPRENDE UNA SECUENCIA DE ADN QUE CODIFICA UN VIRUS PRRS NORTEAMERICANO, CÉLULA HUESPED, PLÁSMIDO, MÉTODO PARA GENERAR UN VIRUS PRRS NORTEAMERICANO Y VACUNA.
Kozlovska et al. Recombinant RNA phage Qβ capsid particles synthesized and self-assembled in Escherichia coli
ES2664505T3 (es) Secuencias de serotipo 9 de virus adeno-asociado (AAV), vectores que las contienen, y usos de las mismas
CA2196555A1 (en) Vr-2332 viral nucleotide sequence and methods of use
AR044724A1 (es) Promotores del virus de la rizadura amarilla del cestrum
MXPA02006888A (es) Flavivirus recombinantes y metodos para utilizar los mismos.
DK0724642T4 (da) Nucleinsyrevektor, sammensætning indeholdende en sådan vektor og vaccine til immunisering mod hepatitis
ES2285832T3 (es) Complejo de peptido antigenico-proteina de choque termico modificada.
JP2015521465A5 (es)
RU2015135890A (ru) Композиция вакцины
MX9202512A (es) Virus de avipox recombinante, cultivo de celulas infectadas por este virusy vacunas para las aves de corral derivadas de este virus.
AR008570A1 (es) Materiales recombinantes y metodos para la produccion de hidroxilasas de limoneno
ES2566146T3 (es) Virus de ARN oncolítico genéticamente estable, método de fabricación y uso del mismo
MXPA05005202A (es) Vacuna.
ATE354662T1 (de) Modifizierte hpv e6- und e7-gene und -proteine als impfstoff
BR9811096A (pt) Sequências, moléculas, vetores e vacinas de dna recombinante para doença do calcivìrus felino e processo para a produção e o uso dos mesmos
DK1432439T3 (da) Middel til forbedring af immunsvaret
DE69318716D1 (de) Anti-Katze Immundefiziensvirus (FIV) Impfstoffe
BR9806084A (pt) Vetor de poliovirus sabin tipo i, recombinante ou quimérico de replicação competente, seus métodos de produção e célula hospedeira
CU23245A1 (es) CADENAS QUIMéRICAS CODIFICANTES PARA PROTEINAS INDUCTORAS DE EFECTOS CONTRA VIRUS. PREPARADOS UTILIZANDO PROTEINAS QUIMéRICAS
Nomoto et al. Restriction map of double-stranded DNA copy synthesized from poliovirus Sabin 1 RNA
ATE160377T1 (de) Erzeugung von hybrid-genen und proteinen durch rekombination mittels viren
RU2019113940A (ru) Мозаичные вакцины от вируса ящура серотипа а
TH51753B (th) cDNA โคลน ที่ติดเชื้อของไวรัสกลุ่มอาการโรคเกี่ยวกับการสืบพันธ์และการหายใจของสุกร (PRRS) สายพันธ์อเมริกาเหนือและการใช้ cDNA โคลนนี้
CA2351010A1 (en) A broad spectrum infectious bursal disease virus vaccine

Legal Events

Date Code Title Description
FG Grant, registration