EP1068362A4 - Hepatitis c virus ns5b compositions and methods of use thereof - Google Patents

Hepatitis c virus ns5b compositions and methods of use thereof

Info

Publication number
EP1068362A4
EP1068362A4 EP99921379A EP99921379A EP1068362A4 EP 1068362 A4 EP1068362 A4 EP 1068362A4 EP 99921379 A EP99921379 A EP 99921379A EP 99921379 A EP99921379 A EP 99921379A EP 1068362 A4 EP1068362 A4 EP 1068362A4
Authority
EP
European Patent Office
Prior art keywords
hepatitis
compositions
methods
virus ns5b
ns5b
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99921379A
Other languages
German (de)
French (fr)
Other versions
EP1068362A1 (en
Inventor
Marc S Collett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viropharma Biologics LLC
Original Assignee
Viropharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viropharma Inc filed Critical Viropharma Inc
Publication of EP1068362A1 publication Critical patent/EP1068362A1/en
Publication of EP1068362A4 publication Critical patent/EP1068362A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
EP99921379A 1998-04-02 1999-04-02 Hepatitis c virus ns5b compositions and methods of use thereof Withdrawn EP1068362A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8050998P 1998-04-02 1998-04-02
US80509P 1998-04-02
US9035698P 1998-06-23 1998-06-23
US90356P 1998-06-23
PCT/US1999/007404 WO1999051781A1 (en) 1998-04-02 1999-04-02 Hepatitis c virus ns5b compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
EP1068362A1 EP1068362A1 (en) 2001-01-17
EP1068362A4 true EP1068362A4 (en) 2005-07-20

Family

ID=26763614

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99921379A Withdrawn EP1068362A4 (en) 1998-04-02 1999-04-02 Hepatitis c virus ns5b compositions and methods of use thereof

Country Status (6)

Country Link
EP (1) EP1068362A4 (en)
JP (1) JP2002510509A (en)
AU (1) AU768177B2 (en)
CA (1) CA2325016A1 (en)
IL (1) IL138804A0 (en)
WO (1) WO1999051781A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6461845B1 (en) * 1995-09-27 2002-10-08 Emory University Recombinant hepatitis C virus RNA replicase
JP2003514562A (en) * 1999-11-23 2003-04-22 バイロファーマ・インコーポレイテッド Polymerase compositions and methods of use
CA2389691A1 (en) * 2000-04-07 2001-10-18 Shionogi & Co., Ltd. A pre-incubation method for an assay of an inhibitor to an hcv rna-dependent rna polymerase
US20030143528A1 (en) * 2000-05-15 2003-07-31 Michinori Kohara Vector for analayzing replication mechanism of rna virus and use thereof
CA2439176A1 (en) * 2001-03-08 2002-09-12 Boehringer Ingelheim (Canada) Ltd. Assay for identifying inhibitors of the rna dependent rna polymerase (ns5b) of hcv
EP1256628A3 (en) * 2001-05-10 2003-03-19 Agouron Pharmaceuticals, Inc. Hepatitis c virus (hcv) ns5b rna polymerase and mutants thereof
WO2005070957A1 (en) 2004-01-09 2005-08-04 Merck & Co., Inc. Hcv rna-dependent rna polymerase
US20100227314A1 (en) * 2007-08-09 2010-09-09 Dmitry Alexandrovich Gryadunov Method of identification of genotype and subtype of hepatitis c virus on a biological microchip

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996037619A1 (en) * 1995-05-25 1996-11-28 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Method for reproducing in vitro the rna-dependent rna polymerase and terminal nucleotidyl transferase activities encoded by hepatitis c virus (hcv)
WO1997012033A1 (en) * 1995-09-27 1997-04-03 Emory University Recombinant hepatitis c virus rna replicase

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5372928A (en) * 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
ES2219637T3 (en) * 1990-04-04 2004-12-01 Chiron Corporation PROTEASE OF THE HEPATITIS VIRUS C.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996037619A1 (en) * 1995-05-25 1996-11-28 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Method for reproducing in vitro the rna-dependent rna polymerase and terminal nucleotidyl transferase activities encoded by hepatitis c virus (hcv)
WO1997012033A1 (en) * 1995-09-27 1997-04-03 Emory University Recombinant hepatitis c virus rna replicase

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 20 October 1995 (1995-10-20), ENOMOTO, N.: "Hepatitis C virus (strain HCV-1b, clone HCV-K1-R2), complete genome sequence" *
DATABASE EMBL 5 January 1998 (1998-01-05), LOHMAN ET AL.: "RNA-dependent RNA-polymerase (Fragment)." *
ENOMOTO N ET AL: "COMPARISON OF FULL-LENGTH SEQUENCES OF INTERFERON-SENSITIVE AND RESISTANT HEPATITIS C VIRUS 1B", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 96, no. 1, July 1995 (1995-07-01), pages 224 - 230, XP002910878, ISSN: 0021-9738 *
LOHMANN V ET AL: "BIOCHEMICAL PROPERTIES OF HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE AND INDENTIFICATION OF AMINO ACID SEQUENCE MOTIFS ESSENTIAL FOR ENZYMATIC ACTIVITY", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 71, no. 11, November 1997 (1997-11-01), pages 8416 - 8428, XP002931582, ISSN: 0022-538X *
See also references of WO9951781A1 *

Also Published As

Publication number Publication date
CA2325016A1 (en) 1999-10-14
JP2002510509A (en) 2002-04-09
AU768177B2 (en) 2003-12-04
IL138804A0 (en) 2001-10-31
AU3861099A (en) 1999-10-25
WO1999051781A9 (en) 2000-05-04
EP1068362A1 (en) 2001-01-17
WO1999051781A1 (en) 1999-10-14

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Legal Events

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