AP2466A - Preparation of pregabalin and related compounds - Google Patents
Preparation of pregabalin and related compoundsInfo
- Publication number
- AP2466A AP2466A AP2006003846A AP2006003846A AP2466A AP 2466 A AP2466 A AP 2466A AP 2006003846 A AP2006003846 A AP 2006003846A AP 2006003846 A AP2006003846 A AP 2006003846A AP 2466 A AP2466 A AP 2466A
- Authority
- AP
- ARIPO
- Prior art keywords
- pregabalin
- preparation
- related compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/12—Formation of amino and carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58167104P | 2004-06-21 | 2004-06-21 | |
US62903404P | 2004-11-18 | 2004-11-18 | |
PCT/IB2005/001924 WO2006000904A2 (en) | 2004-06-21 | 2005-06-09 | Preparation of pregabalin and related compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
AP2006003846A0 AP2006003846A0 (en) | 2006-12-31 |
AP2466A true AP2466A (en) | 2012-09-17 |
Family
ID=35295367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2006003846A AP2466A (en) | 2004-06-21 | 2005-06-09 | Preparation of pregabalin and related compounds |
Country Status (33)
Country | Link |
---|---|
US (4) | US20050283023A1 (de) |
EP (1) | EP1831154B1 (de) |
JP (5) | JP4174551B2 (de) |
KR (3) | KR100847927B1 (de) |
CN (2) | CN102102114B (de) |
AP (1) | AP2466A (de) |
AR (1) | AR049446A1 (de) |
AT (1) | ATE455093T1 (de) |
AU (1) | AU2005256945B2 (de) |
BR (1) | BRPI0512347B8 (de) |
CA (1) | CA2571040C (de) |
CR (2) | CR8765A (de) |
CY (1) | CY1110337T1 (de) |
DE (1) | DE602005018965D1 (de) |
DK (1) | DK1831154T3 (de) |
EA (3) | EA011765B1 (de) |
ES (1) | ES2336014T3 (de) |
GE (1) | GEP20104895B (de) |
HK (2) | HK1104024A1 (de) |
HR (1) | HRP20100054T1 (de) |
IL (1) | IL179614A0 (de) |
MA (1) | MA28674B1 (de) |
ME (1) | ME01067B (de) |
MX (1) | MXPA06014228A (de) |
NO (1) | NO338097B1 (de) |
NZ (1) | NZ552220A (de) |
PL (1) | PL1831154T3 (de) |
PT (1) | PT1831154E (de) |
RS (1) | RS51210B (de) |
SI (1) | SI1831154T1 (de) |
TW (6) | TWI405747B (de) |
UA (1) | UA83575C2 (de) |
WO (1) | WO2006000904A2 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL189872B1 (pl) | 1996-07-24 | 2005-10-31 | Warner Lambert Co | Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu |
MX2007012396A (es) | 2005-04-06 | 2007-11-20 | Teva Pharma | Formas cristalinas de pregabalina. |
CA2603215A1 (en) * | 2005-04-11 | 2006-10-19 | Teva Pharmaceutical Industries Ltd. | Process for making (s)-pregabalin |
US7488846B2 (en) | 2005-04-11 | 2009-02-10 | Teva Pharmaceuical Industries Ltd. | Pregabalin free of lactam and a process for preparation thereof |
ATE523484T1 (de) | 2005-05-10 | 2011-09-15 | Teva Pharma | Optische lösung a us 3-carbamoylmethyl-5-methyl- hexansäure |
KR20070067077A (ko) | 2005-05-10 | 2007-06-27 | 테바 파마슈티컬 인더스트리즈 리미티드 | 이소부틸글루타르산을 함유하지 않는 프레가발린 및 이의제조 방법 |
CA2604602A1 (en) | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Method for the preparation of pregabalin and salts thereof |
CZ297970B6 (cs) * | 2005-08-10 | 2007-05-09 | Zentiva, A. S | Zpusob výroby (S)-3-(aminomethyl)-5-methyl-hexanové kyseliny (pregabalinu) |
WO2007035890A1 (en) | 2005-09-19 | 2007-03-29 | Teva Pharmaceutical Industries Ltd. | An asymmetric synthesis of ( s ) - ( + ) -3- (aminomethyl) -5-methylhexanoic acid |
WO2007139933A2 (en) | 2006-05-24 | 2007-12-06 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof |
WO2007143152A2 (en) * | 2006-05-31 | 2007-12-13 | Teva Pharmaceutical Industries Ltd. | Preparation of (s)-pregabalin-nitrile |
BRPI0702897A2 (pt) * | 2006-05-31 | 2011-03-15 | Teva Pharmaceutical Ind Ltda | processo para preparar um intermediário de pregabalina |
EP2021318A2 (de) | 2007-03-22 | 2009-02-11 | Teva Pharmaceutical Industries Ltd. | Synthese von (s) - (+)-3-(aminomethyl) -5-methylhexansäure |
JP5157576B2 (ja) | 2007-05-14 | 2013-03-06 | 住友化学株式会社 | 光学活性2−アルキル−1,1,3−トリアルコキシカルボニルプロパンの製造方法 |
EP1992609A1 (de) * | 2007-05-14 | 2008-11-19 | Dipharma Francis S.r.l. | Verfahren für die Herstellung einer (S)(+)-3-(Aminomethyl)-5-Methylhexan-Säure |
KR100846419B1 (ko) * | 2007-08-10 | 2008-07-15 | 한국과학기술원 | 프레가발린의 신규한 제조 방법 |
US20090062393A1 (en) * | 2007-08-29 | 2009-03-05 | Protia, Llc | Deuterium-enriched pregabalin |
WO2009046309A2 (en) * | 2007-10-03 | 2009-04-09 | Teva Pharmaceutical Industries Ltd. | Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof |
ITMI20072262A1 (it) | 2007-12-03 | 2009-06-04 | Dipharma Francis Srl | Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico |
EP2225199A2 (de) * | 2007-12-18 | 2010-09-08 | Watson Pharma Private Limited | Verbessertes herstellungsverfahren für (s)-pregabalin |
EP2222630A1 (de) * | 2007-12-26 | 2010-09-01 | Generics (UK) Limited | Verfahren für pregabalin |
EP2116618A1 (de) * | 2008-05-09 | 2009-11-11 | Agency for Science, Technology And Research | Diagnose und Behandlung des Kawasaki-Syndroms |
WO2009141362A2 (en) * | 2008-05-21 | 2009-11-26 | Sandoz Ag | Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester |
US20090312560A1 (en) * | 2008-06-10 | 2009-12-17 | Lambertus Thijs | Processes for making pregabalin and intermediates therefor |
KR20100107500A (ko) * | 2008-06-23 | 2010-10-05 | 테바 파마슈티컬 인더스트리즈 리미티드 | (s) 또는 (r)-이소-부틸-글루타릭 에스테르의 입체선택적 효소 합성방법 |
WO2010070593A2 (en) | 2008-12-19 | 2010-06-24 | Pfizer Ireland Pharmaceuticals | Malonate esters |
IT1394292B1 (it) | 2009-05-07 | 2012-06-06 | Dipharma Francis Srl | Procedimento per la sintesi di pregabalina |
WO2011141923A2 (en) | 2010-05-14 | 2011-11-17 | Lupin Limited | Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin |
WO2012025861A1 (en) | 2010-08-23 | 2012-03-01 | Pfizer Manufacturing Ireland | Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin |
WO2012059797A1 (en) * | 2010-11-04 | 2012-05-10 | Lupin Limited | Process for synthesis of (s) - pregabalin |
KR101306585B1 (ko) * | 2011-04-14 | 2013-09-10 | 한국외국어대학교 연구산학협력단 | 프레가발린의 제조방법 |
CN102952057B (zh) * | 2012-11-07 | 2015-09-09 | 浙江普洛家园药业有限公司 | 一种4-异丁基吡咯烷-2-酮的制备方法 |
JP6225490B2 (ja) * | 2013-05-31 | 2017-11-08 | 大日本印刷株式会社 | 医薬品包装体 |
US10076550B2 (en) * | 2014-06-25 | 2018-09-18 | Council Of Scientific & Industrial Research | Synergistic pharmaceutical composition for gastroinestinal disorders |
WO2016075082A1 (en) | 2014-11-10 | 2016-05-19 | Sandoz Ag | Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam |
CN104557576B (zh) * | 2014-12-19 | 2019-07-19 | 浙江华海药业股份有限公司 | 一种高纯度普瑞巴林的制备方法 |
CN105348125A (zh) * | 2015-11-26 | 2016-02-24 | 太仓运通生物化工有限公司 | 一种以异戊醛为原料合成普瑞巴林的方法 |
CN107445864B (zh) * | 2017-08-09 | 2020-01-17 | 无锡殷达尼龙有限公司 | 一种纯化长碳链氰基酸产物的方法 |
CN108358799B (zh) * | 2018-04-24 | 2020-11-10 | 贵州师范大学 | 一种普瑞巴林的制备方法 |
CN109503403B (zh) * | 2018-12-21 | 2021-11-16 | 卓和药业集团股份有限公司 | 一种普瑞巴林的拆分方法 |
CN113248416B (zh) * | 2020-02-10 | 2024-03-26 | 江西博腾药业有限公司 | 1-((苄氧基)羰基)-4-乙基吡咯烷-3-羧酸的制备方法及其应用 |
EP4103168A4 (de) * | 2020-02-14 | 2024-04-24 | Council Of Scientific & Industrial Research | Verfahren zur herstellung von gamma-aminobuttersäuren und deren analogen |
CN111205288B (zh) | 2020-02-19 | 2021-03-30 | 四川大学 | 一种(1S,12bS)内酰胺酯化合物的合成方法 |
CN113651717A (zh) * | 2021-08-05 | 2021-11-16 | 浙江工业大学 | 一种光学纯异丁基丁二腈的消旋方法 |
CN113880724A (zh) * | 2021-12-06 | 2022-01-04 | 南京桦冠生物技术有限公司 | 一种3-(2-氨基苯基)-2-丙烯酸酯的制备方法 |
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US20030212290A1 (en) * | 2000-01-27 | 2003-11-13 | Burk Mark Joseph | Asymmetric synthesis of pregabalin |
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US20030225149A1 (en) * | 2002-04-30 | 2003-12-04 | Blazecka Peter G. | Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids |
FR2849024B1 (fr) * | 2002-12-20 | 2007-11-02 | Aventis Pharma Sa | Nouveaux composes chiraux derives d'esters de l'acide hexanoique, procede et intermediaires de preparation, utilisation a la synthese de l'acide 2-(bromomethyl)2-ethyl hexanoique chiral |
JP2006061112A (ja) * | 2004-08-30 | 2006-03-09 | Sumitomo Chemical Co Ltd | 光学活性な2−(シクロペンチルメチル)−マロン酸モノエステルの製造方法 |
BRPI0702897A2 (pt) * | 2006-05-31 | 2011-03-15 | Teva Pharmaceutical Ind Ltda | processo para preparar um intermediário de pregabalina |
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US5637767A (en) * | 1995-06-07 | 1997-06-10 | Warner-Lambert Company | Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
US20030212290A1 (en) * | 2000-01-27 | 2003-11-13 | Burk Mark Joseph | Asymmetric synthesis of pregabalin |
Non-Patent Citations (1)
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GLENN M. SAMMIS AND ERIC N. JACOBSEN: "Highly Enantioselective, Catalytic Conjugate Addition of Cyanide to alpha,beta-Unsaturated Imides" J. AM. CHEM. SOC., vol. 125, 2003, pages 4442-4443, XP002356467 schemes 2, 3 * |
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