ZA200610775B - Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors - Google Patents

Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors Download PDF

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Publication number
ZA200610775B
ZA200610775B ZA200610775A ZA200610775A ZA200610775B ZA 200610775 B ZA200610775 B ZA 200610775B ZA 200610775 A ZA200610775 A ZA 200610775A ZA 200610775 A ZA200610775 A ZA 200610775A ZA 200610775 B ZA200610775 B ZA 200610775B
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South Africa
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formula
compound
hydrogen
parp
compounds
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ZA200610775A
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English (en)
Inventor
Der Aa Marcel Jozef Maria Van
Heertum Henricus Maria Theresia Albert Van
Dun Jacobus Alphonse Josephus Van
Maria Victorina Francisca Somers
Wal Boudewijn Lepold Wouters
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Janssen Pharmaceutica Nv
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Publication of ZA200610775B publication Critical patent/ZA200610775B/en

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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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ZA200610775A 2004-06-30 2006-12-20 Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors ZA200610775B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04076887 2004-06-30

Publications (1)

Publication Number Publication Date
ZA200610775B true ZA200610775B (en) 2008-03-26

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ID=34928320

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Application Number Title Priority Date Filing Date
ZA200610775A ZA200610775B (en) 2004-06-30 2006-12-20 Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors
ZA200610772A ZA200610772B (en) 2004-06-30 2006-12-20 Quinazolinone derivatives as PARP inhibitors

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Application Number Title Priority Date Filing Date
ZA200610772A ZA200610772B (en) 2004-06-30 2006-12-20 Quinazolinone derivatives as PARP inhibitors

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US (5) US7875621B2 (ja)
EP (2) EP1771422B1 (ja)
JP (2) JP4969443B2 (ja)
KR (2) KR101184036B1 (ja)
CN (2) CN1976906B (ja)
AR (2) AR049656A1 (ja)
AT (2) ATE498613T1 (ja)
AU (2) AU2005259188B2 (ja)
BR (2) BRPI0512797A (ja)
CA (2) CA2568835C (ja)
DE (1) DE602005026391D1 (ja)
EA (2) EA012837B1 (ja)
ES (2) ES2361162T3 (ja)
HK (2) HK1105631A1 (ja)
IL (2) IL180382A (ja)
MX (2) MXPA06014543A (ja)
MY (2) MY148322A (ja)
NO (2) NO339883B1 (ja)
NZ (2) NZ551680A (ja)
SG (2) SG154435A1 (ja)
TW (2) TWI361188B (ja)
UA (2) UA85593C2 (ja)
WO (2) WO2006003150A1 (ja)
ZA (2) ZA200610775B (ja)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2546002C (en) 2003-11-20 2012-09-18 Janssen Pharmaceutica N.V. 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
CA2546300C (en) 2003-11-20 2012-10-02 Janssen Pharmaceutica N.V. 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
ES2563954T3 (es) 2004-06-30 2016-03-16 Janssen Pharmaceutica Nv Derivados de ftalazina como inhibidores de PARP
MXPA06014543A (es) 2004-06-30 2007-03-23 Janssen Pharmaceutica Nv Derivados de quinazolinona como inhibidores de la poli(adp-ribosa)polimerasa-i.
CN1980913B (zh) 2004-06-30 2011-12-14 詹森药业有限公司 作为parp抑制剂的喹唑啉二酮衍生物
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
SG164368A1 (en) 2005-07-18 2010-09-29 Bipar Sciences Inc Treatment of cancer
WO2008030891A2 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
CA2662517A1 (en) 2006-09-05 2008-03-13 Jerome Moore Treatment of cancer
PL2109608T3 (pl) * 2007-01-10 2011-08-31 Msd Italia Srl Indazole podstawione grupą amidową jako inhibitory polimerazy poli(ADP-rybozy)-(PARP)
WO2008107478A1 (en) 2007-03-08 2008-09-12 Janssen Pharmaceutica Nv Quinolinone derivatives as parp and tank inhibitors
JP5525447B2 (ja) 2007-10-26 2014-06-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐ阻害剤としてのキノリノン誘導体
US7732491B2 (en) 2007-11-12 2010-06-08 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
JP5464609B2 (ja) 2008-03-27 2014-04-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ チューブリン重合阻害剤としてのキナゾリノン誘導体
WO2009118382A1 (en) 2008-03-27 2009-10-01 Janssen Pharmaceutica Nv Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors
WO2010081778A1 (en) 2009-01-17 2010-07-22 Universität Zürich Blockers of parp for the prevention and treatment of helicobacter pylori induced gastric cancer
WO2011058367A2 (en) 2009-11-13 2011-05-19 Astrazeneca Ab Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor
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