ZA200301526B - Vaccine against streptococcus pneumoniae. - Google Patents
Vaccine against streptococcus pneumoniae. Download PDFInfo
- Publication number
- ZA200301526B ZA200301526B ZA200301526A ZA200301526A ZA200301526B ZA 200301526 B ZA200301526 B ZA 200301526B ZA 200301526 A ZA200301526 A ZA 200301526A ZA 200301526 A ZA200301526 A ZA 200301526A ZA 200301526 B ZA200301526 B ZA 200301526B
- Authority
- ZA
- South Africa
- Prior art keywords
- protein
- immunogenic composition
- polysaccharide
- group
- phtd
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims description 26
- 241000193998 Streptococcus pneumoniae Species 0.000 title claims description 20
- 229940031000 streptococcus pneumoniae Drugs 0.000 title claims description 19
- 102000004169 proteins and genes Human genes 0.000 claims description 78
- 108090000623 proteins and genes Proteins 0.000 claims description 78
- 229920001282 polysaccharide Polymers 0.000 claims description 44
- 239000005017 polysaccharide Substances 0.000 claims description 44
- 150000004676 glycans Chemical class 0.000 claims description 43
- 108091007433 antigens Proteins 0.000 claims description 33
- 102000036639 antigens Human genes 0.000 claims description 33
- 239000000203 mixture Substances 0.000 claims description 24
- 239000000427 antigen Substances 0.000 claims description 22
- 239000002671 adjuvant Substances 0.000 claims description 16
- 230000002163 immunogen Effects 0.000 claims description 16
- 101100453077 Botryococcus braunii HDR gene Proteins 0.000 claims description 13
- 230000002265 prevention Effects 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 206010033078 Otitis media Diseases 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 6
- 102000014914 Carrier Proteins Human genes 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 108010078791 Carrier Proteins Proteins 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 230000004044 response Effects 0.000 claims description 3
- 241000606768 Haemophilus influenzae Species 0.000 claims description 2
- 159000000013 aluminium salts Chemical class 0.000 claims 2
- 229910000329 aluminium sulfate Inorganic materials 0.000 claims 2
- 230000003308 immunostimulating effect Effects 0.000 claims 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 2
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 1
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 101710188053 Protein D Proteins 0.000 claims 1
- 101710132893 Resolvase Proteins 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 229960001438 immunostimulant agent Drugs 0.000 claims 1
- 239000003022 immunostimulating agent Substances 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 1
- 229930182490 saponin Natural products 0.000 claims 1
- 150000007949 saponins Chemical class 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
- 229960001005 tuberculin Drugs 0.000 claims 1
- 230000027455 binding Effects 0.000 description 12
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 12
- 229960001231 choline Drugs 0.000 description 12
- 210000000987 immune system Anatomy 0.000 description 9
- 206010035664 Pneumonia Diseases 0.000 description 8
- 150000001413 amino acids Chemical class 0.000 description 7
- 229920002704 polyhistidine Polymers 0.000 description 7
- 101710099976 Photosystem I P700 chlorophyll a apoprotein A1 Proteins 0.000 description 6
- 108010076504 Protein Sorting Signals Proteins 0.000 description 6
- 238000012217 deletion Methods 0.000 description 6
- 230000037430 deletion Effects 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
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- 101710164918 Choline-binding protein Proteins 0.000 description 5
- 210000001744 T-lymphocyte Anatomy 0.000 description 5
- 108091016312 choline binding proteins Proteins 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 208000035109 Pneumococcal Infections Diseases 0.000 description 4
- 230000000890 antigenic effect Effects 0.000 description 4
- 210000003719 b-lymphocyte Anatomy 0.000 description 4
- 230000001404 mediated effect Effects 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- 108700012359 toxins Proteins 0.000 description 4
- 108010052285 Membrane Proteins Proteins 0.000 description 3
- 102000018697 Membrane Proteins Human genes 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229940124733 pneumococcal vaccine Drugs 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 208000031729 Bacteremia Diseases 0.000 description 2
- 108010060123 Conjugate Vaccines Proteins 0.000 description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
- 201000009906 Meningitis Diseases 0.000 description 2
- -1 PRP polysaccharide Chemical class 0.000 description 2
- 208000009362 Pneumococcal Pneumonia Diseases 0.000 description 2
- 206010035728 Pneumonia pneumococcal Diseases 0.000 description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
- 229940124858 Streptococcus pneumoniae vaccine Drugs 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000005875 antibody response Effects 0.000 description 2
- 230000000981 bystander Effects 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 229940031670 conjugate vaccine Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 108700039582 histidine triad Proteins 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 208000022218 streptococcal pneumonia Diseases 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- NJNWCIAPVGRBHO-UHFFFAOYSA-N 2-hydroxyethyl-dimethyl-[(oxo-$l^{5}-phosphanylidyne)methyl]azanium Chemical group OCC[N+](C)(C)C#P=O NJNWCIAPVGRBHO-UHFFFAOYSA-N 0.000 description 1
- 101100420868 Anuroctonus phaiodactylus phtx gene Proteins 0.000 description 1
- 201000001178 Bacterial Pneumonia Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000282461 Canis lupus Species 0.000 description 1
- 101710163595 Chaperone protein DnaK Proteins 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 101710178376 Heat shock 70 kDa protein Proteins 0.000 description 1
- 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 description 1
- 208000017604 Hodgkin disease Diseases 0.000 description 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
- 102000043129 MHC class I family Human genes 0.000 description 1
- 108091054437 MHC class I family Proteins 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 101710183389 Pneumolysin Proteins 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 201000005010 Streptococcus pneumonia Diseases 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 101710151579 Zinc metalloproteinase Proteins 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001727 anti-capsular Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
- 229940047650 haemophilus influenzae Drugs 0.000 description 1
- 108010037896 heparin-binding hemagglutinin Proteins 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006054 immunological memory Effects 0.000 description 1
- 208000022760 infectious otitis media Diseases 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000029226 lipidation Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 229940124731 meningococcal vaccine Drugs 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 210000004897 n-terminal region Anatomy 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- 230000001662 opsonic effect Effects 0.000 description 1
- 229940031960 pneumococcal polysaccharide vaccine Drugs 0.000 description 1
- 229960001973 pneumococcal vaccines Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 208000007056 sickle cell anemia Diseases 0.000 description 1
- 238000010911 splenectomy Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0208—Specific bacteria not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/125—Picornaviridae, e.g. calicivirus
- A61K39/13—Poliovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0022742.1A GB0022742D0 (en) | 2000-09-15 | 2000-09-15 | Vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200301526B true ZA200301526B (en) | 2004-06-04 |
Family
ID=9899575
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200301526A ZA200301526B (en) | 2000-09-15 | 2003-02-25 | Vaccine against streptococcus pneumoniae. |
| ZA200301524A ZA200301524B (en) | 2000-09-15 | 2003-02-25 | Vaccine. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200301524A ZA200301524B (en) | 2000-09-15 | 2003-02-25 | Vaccine. |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US20060051361A1 (enExample) |
| EP (6) | EP2305297A1 (enExample) |
| JP (3) | JP4903975B2 (enExample) |
| KR (5) | KR100991916B1 (enExample) |
| CN (3) | CN101502648B (enExample) |
| AT (1) | ATE516815T1 (enExample) |
| AU (4) | AU3819302A (enExample) |
| BR (2) | BR0113821A (enExample) |
| CA (2) | CA2421998C (enExample) |
| CY (1) | CY1111915T1 (enExample) |
| CZ (2) | CZ305343B6 (enExample) |
| DK (1) | DK1317279T3 (enExample) |
| ES (4) | ES2659400T3 (enExample) |
| GB (1) | GB0022742D0 (enExample) |
| HU (2) | HUP0301092A3 (enExample) |
| IL (4) | IL154608A0 (enExample) |
| MX (2) | MXPA03002264A (enExample) |
| NO (2) | NO337730B1 (enExample) |
| NZ (2) | NZ524287A (enExample) |
| PL (2) | PL209247B1 (enExample) |
| PT (1) | PT1317279E (enExample) |
| SI (1) | SI1317279T1 (enExample) |
| WO (2) | WO2002022168A2 (enExample) |
| ZA (2) | ZA200301526B (enExample) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7078042B2 (en) * | 1995-09-15 | 2006-07-18 | Uab Research Foundation | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
| US7129339B1 (en) | 1997-07-02 | 2006-10-31 | Sanofi Pasteur Limited | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| US6800744B1 (en) | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| US20010016200A1 (en) | 1998-04-23 | 2001-08-23 | Briles David E. | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
| US7128918B1 (en) * | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
| CA2366152A1 (en) * | 1999-03-19 | 2000-09-28 | Smithkline Beecham Biologicals S.A. | Streptococcus pneumoniae vaccine |
| US7074415B2 (en) * | 2000-06-20 | 2006-07-11 | Id Biomedical Corporation | Streptococcus antigens |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| US7262024B2 (en) | 2001-12-20 | 2007-08-28 | Id Biomedical Corporation | Streptococcus antigens |
| US8691243B2 (en) | 2002-04-02 | 2014-04-08 | Ben-Gurion University Of The Negev Research And Development Authority | Protein-based Streptococcus pneumoniae vaccine |
| EP2275127B1 (en) * | 2002-04-02 | 2012-09-19 | Ben Gurion University Of The Negev Research And Development Authority | Protein-based streptococcus pneumoniae vaccines |
| EP2351579B1 (en) | 2002-10-11 | 2016-09-21 | Novartis Vaccines and Diagnostics S.r.l. | Polypeptide vaccines for broad protection against hypervirulent meningococcal lineages |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| US8229903B2 (en) * | 2002-12-19 | 2012-07-24 | International Business Machines Corporation | Suggesting data interpretations and patterns for updating policy documents |
| DK1587537T3 (da) | 2003-01-30 | 2012-07-16 | Novartis Ag | Injicerbare vacciner mod multiple meningococ-serogrupper |
| MXPA05009579A (es) | 2003-03-13 | 2005-11-17 | Glaxosmithkline Biolog Sa | Proceso de purificacion para citolisina bacteriana. |
| EP1477802A1 (en) * | 2003-05-16 | 2004-11-17 | Erasmus Universiteit Rotterdam | Method for selecting and producing vaccine components and vaccines based thereon |
| ES2397923T3 (es) | 2003-10-02 | 2013-03-12 | Novartis Ag | Vacunas líquidas para múltiples serogrupos meningocócicos |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| AU2005286798A1 (en) * | 2004-09-21 | 2006-03-30 | Sanofi Pasteur, Inc. | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine |
| AU2011253684B8 (en) * | 2005-04-08 | 2013-07-11 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| IL308456A (en) | 2005-04-08 | 2024-01-01 | Wyeth Llc | A multivalent pneumomuroral protein-polysaccharide conjugate preparation |
| GB0522765D0 (en) | 2005-11-08 | 2005-12-14 | Chiron Srl | Combination vaccine manufacture |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| JP5792920B2 (ja) | 2005-12-22 | 2015-10-14 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
| AU2006336520B2 (en) * | 2005-12-28 | 2011-09-15 | The Uab Research Foundation | Pneumococcal serotypes |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| US20110002962A1 (en) * | 2006-08-17 | 2011-01-06 | The Uab Research Foundation | Immunogenic PcpA Polypeptides and Uses Thereof |
| CN101678091A (zh) * | 2007-05-24 | 2010-03-24 | 葛兰素史密丝克莱恩生物有限公司 | 冷冻干燥的抗原组合物 |
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- 2001-09-12 CA CA2421998A patent/CA2421998C/en not_active Expired - Fee Related
- 2001-09-12 KR KR1020117026231A patent/KR101268790B1/ko not_active Expired - Fee Related
- 2001-09-12 PT PT01984626T patent/PT1317279E/pt unknown
- 2001-09-12 CN CNB018157467A patent/CN100486642C/zh not_active Expired - Fee Related
- 2001-09-12 HU HU0301092A patent/HUP0301092A3/hu unknown
- 2001-09-12 CZ CZ2003-757A patent/CZ305343B6/cs not_active IP Right Cessation
- 2001-09-12 US US10/380,563 patent/US20040081662A1/en not_active Abandoned
- 2001-09-12 EP EP10178332.2A patent/EP2314313B1/en not_active Expired - Lifetime
- 2001-09-12 IL IL15460801A patent/IL154608A0/xx unknown
- 2001-09-12 AU AU2002238193A patent/AU2002238193B2/en not_active Ceased
- 2001-09-12 JP JP2002526417A patent/JP4880184B2/ja not_active Expired - Fee Related
- 2001-09-12 BR BR0113822-7A patent/BR0113822A/pt not_active IP Right Cessation
- 2001-09-12 WO PCT/EP2001/010568 patent/WO2002022167A2/en not_active Ceased
- 2001-09-12 KR KR1020107014638A patent/KR20100091241A/ko not_active Ceased
- 2001-09-12 ES ES01984626T patent/ES2368902T3/es not_active Expired - Lifetime
- 2001-09-12 IL IL15460701A patent/IL154607A0/xx unknown
- 2001-09-12 DK DK01984626.0T patent/DK1317279T3/da active
- 2001-09-12 EP EP01984627.8A patent/EP1317280B1/en not_active Expired - Lifetime
- 2001-09-12 MX MXPA03002265A patent/MXPA03002265A/es active IP Right Grant
- 2001-09-12 NZ NZ524286A patent/NZ524286A/en not_active IP Right Cessation
- 2001-09-12 SI SI200131001T patent/SI1317279T1/sl unknown
- 2001-09-12 HU HU0301043A patent/HUP0301043A3/hu not_active Application Discontinuation
- 2001-09-12 CZ CZ2003-756A patent/CZ305324B6/cs not_active IP Right Cessation
- 2001-09-12 PL PL361401A patent/PL210198B1/pl unknown
- 2001-09-12 CN CNB018157483A patent/CN1253205C/zh not_active Expired - Fee Related
- 2001-09-12 EP EP09173889.8A patent/EP2140878B1/en not_active Expired - Lifetime
- 2001-09-12 ES ES01984627.8T patent/ES2545876T3/es not_active Expired - Lifetime
- 2001-09-12 EP EP10179135A patent/EP2305298A1/en not_active Withdrawn
- 2001-09-12 AU AU2054802A patent/AU2054802A/xx active Pending
- 2001-09-12 KR KR1020037003731A patent/KR100805991B1/ko not_active Expired - Fee Related
- 2001-09-12 KR KR10-2003-7003732A patent/KR20030031188A/ko not_active Ceased
- 2001-09-12 CA CA2422002A patent/CA2422002C/en not_active Expired - Fee Related
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2003
- 2003-02-24 IL IL154608A patent/IL154608A/en not_active IP Right Cessation
- 2003-02-24 IL IL154607A patent/IL154607A/en not_active IP Right Cessation
- 2003-02-25 ZA ZA200301526A patent/ZA200301526B/en unknown
- 2003-02-25 ZA ZA200301524A patent/ZA200301524B/en unknown
- 2003-03-14 NO NO20031184A patent/NO337730B1/no not_active IP Right Cessation
- 2003-03-14 NO NO20031183A patent/NO336186B1/no not_active IP Right Cessation
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2007
- 2007-05-07 US US11/745,006 patent/US20080081050A1/en not_active Abandoned
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2010
- 2010-08-13 US US12/855,734 patent/US20110008419A1/en not_active Abandoned
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2011
- 2011-09-12 JP JP2011198277A patent/JP2012006969A/ja active Pending
- 2011-10-06 CY CY20111100958T patent/CY1111915T1/el unknown
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2013
- 2013-12-10 US US14/101,995 patent/US20140099339A1/en not_active Abandoned
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