ZA200102102B - Dimeric thrombopoietin peptide mimetics binding to MPI receptor and having thrombopoietic activity. - Google Patents

Dimeric thrombopoietin peptide mimetics binding to MPI receptor and having thrombopoietic activity. Download PDF

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Publication number
ZA200102102B
ZA200102102B ZA200102102A ZA200102102A ZA200102102B ZA 200102102 B ZA200102102 B ZA 200102102B ZA 200102102 A ZA200102102 A ZA 200102102A ZA 200102102 A ZA200102102 A ZA 200102102A ZA 200102102 B ZA200102102 B ZA 200102102B
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South Africa
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iegptlrqwlaara
seq
group
tmp
gly
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ZA200102102A
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Chuan-Fa Liu
Ulrich Feige
Janet Cheetham
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Amgen Inc
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/524Thrombopoietin, i.e. C-MPL ligand
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA200102102A 1998-10-23 2001-03-14 Dimeric thrombopoietin peptide mimetics binding to MPI receptor and having thrombopoietic activity. ZA200102102B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10534898P 1998-10-23 1998-10-23

Publications (1)

Publication Number Publication Date
ZA200102102B true ZA200102102B (en) 2001-11-15

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Family Applications (1)

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ZA200102102A ZA200102102B (en) 1998-10-23 2001-03-14 Dimeric thrombopoietin peptide mimetics binding to MPI receptor and having thrombopoietic activity.

Country Status (36)

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US (8) US6835809B1 (cs)
EP (3) EP1783222B1 (cs)
JP (2) JP3820105B2 (cs)
KR (1) KR100719202B1 (cs)
CN (2) CN1810832B (cs)
AR (1) AR020934A1 (cs)
AT (1) ATE348163T1 (cs)
AU (1) AU773891C (cs)
BG (3) BG65663B1 (cs)
BR (1) BRPI9914698B8 (cs)
CA (1) CA2346996C (cs)
CY (4) CY1107526T1 (cs)
CZ (1) CZ302155B6 (cs)
DE (2) DE122009000039I1 (cs)
DK (3) DK1124961T3 (cs)
EA (1) EA003998B1 (cs)
ES (3) ES2388341T3 (cs)
FR (1) FR09C0030I2 (cs)
HK (1) HK1042114B (cs)
HU (1) HU228582B1 (cs)
IL (1) IL142023A0 (cs)
LT (1) LTC1124961I2 (cs)
LU (1) LU91598I2 (cs)
ME (2) MEP42108A (cs)
MY (1) MY126795A (cs)
NL (1) NL300398I2 (cs)
NO (2) NO331027B1 (cs)
NZ (1) NZ510529A (cs)
PL (1) PL219605B1 (cs)
PT (3) PT1124961E (cs)
RS (1) RS51237B (cs)
SI (3) SI2319928T1 (cs)
SK (1) SK287737B6 (cs)
TW (2) TWI250988B (cs)
WO (1) WO2000024770A2 (cs)
ZA (1) ZA200102102B (cs)

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